AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO EA?Ae?IEIA?? ?I. AEAAe. I.Ae. No?aaeanea

Eieoei Na?a?e Eaii?aeiae/

OAeE 616.12:616.12-008.318.1]-073.7-085-089.819.1

Ia?ieneciaeuei? iaaeoeoii/eia? oao?a?eoi??: ee?i?/i? iniaeeaino? oa
e?eoaaiiy

14.01.11 – ea?ae?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy aeieoi?a iaaee/ieo iaoe

Ee?a -1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia a Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai??
IIC Oe?a?ie

Iaoeiaee eiinoeueoaio : aeieoi? iaaee/ieo iaoe , i?ioani?, aeaaeai?e AII
Oe?a?ie Aecye Aai?a?e A?eoi?iae/, caa?aeoaa/ eaoaae?e aini?oaeueii?
oa?ai?? ?2 Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai?? IIC
Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?, /eai — ei?aniiiaeaio IAI oa AII
Oe?a?ie Aia?ia Aieiaeeie? Ieaen?eiae/ caa?aeoaa/ eaoaae?e ea?ae?ieia??
oa ooieoe?iiaeueii? ae?aaiinoeee, Ee?anueei? iaaee/ii? aeaaeai??
i?neyaeeieiiii? ina?oe ?i. I.E.Ooi?ea i. Ee?a

aeieoi? iaaee/ieo iaoe Ia?oiiaiei Ieaenaiae? Ieeieaeiae/ –ea??aiee
a?aeae?eo ?aai?iaoe?? oa ?ioaineaii? oa?ai?? ?inoeoooo ea?ae?ieia?? ?i.
aeaae. I.Ae.No?aaeanea AII Oe?a?ie i. Ee?a

aeieoi? iaaee/ieo iaoe, i?ioani?, Aaiaeao sseia Aa?aiiae/ aieiaiee
iaoeiaee ni?a?ia?oiee a?aeae?eaiiy o??o?a?/iiai e?eoaaiiy iaaooeo aaae
na?oey ?inoeoooo na?oeaai-noaeeiii? o??o?a?? AII Oe?a?ie i. Ee?a

I?ia?aeia onoaiiaa : Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.
Aiaiiieueoey IIC Oe?a?ie i. Ee?a

Caoeno a?aeaoaeaoueny 16 eenoiiaaea 1999 i 10 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e ?inoeooo? ea?ae?ieia?? ?i
aeaae. I.Ae. No?aaeanea AII Oe?a?ie (03151 i. Ee?a , aoe. Ia?iaeiiai
iiie/aiiy 5)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo
ea?ae?ieia?? ?i aeaae. I.Ae. No?aaeanea AII Oe?a?ie (03151 i. Ee?a ,
aoe. Ia?iaeiiai iiie/aiiy 5)

Aaoi?aoa?ao ?ic?neaiee 15 aeiaoiy 1999

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee Ae 26.616.01 Aeaye N.?.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. IOOA iinoathoue iaei??th c nooo?aeo i?iaeai
no/anii? ea?ae?ieia??. Iia? aeiaaeee ia?ieneciaeueieo IOO c’yaeythoueny
c /anoioith, uiiaeiaioa, 36 ia 100000 in?a ianaeaiiy ia ??e, ui
a?aeiia?aea? /anoio? aeyaeaiiy 0,225% (Orejarena et al.,1998). Aei oiai
ae c /anoioith 1-2 aeiaaeee ia 1000 in?a ia ??e c’yaey?oueny iino?eia
IA, yeo iathoue 0,4% ianaeaiiy (Godtfredsen et al.,1983, Kannel et
al.,1982). Uiiaeiaioa, ao?e/? a?eueoith ? /anoioa aeyaeaiiy
ia?ieneciaeueii? IA (Kannel et al.,1992). I?ino? ?ic?aooiee
cana?ae/othoue, ui ca oeeie i?ae-oi iaaaee/eeie a?aenioeaie eeoa o NOA
iae?/o?oueny aeecueei 2000000 iaoe??io?a c IOOA. Aei oiai ae, /anoioa
aeyaeaiiy IOOA i?ia?aneaii c?inoa? c a?eii, neeaaeath/e i?ney 65 ?ie?a
0,616% aeey ia?ieneciaeueieo IOO (Orejarena et al.,1988). oa 5-17% aeey
iino?eii? IA (Krahn et al., 1995, Kannel et al.,1982). Aea ae naia
noa?oa a?oia ? iniiaiei aeaea?aeii iaoe??io?a c ea?ae?iaaneoey?iith
iaoieia??th. Iayai?noue inoaiiuei? cia/ii i?aeaeuo? ?ecee ?icaeoeo
oneeaaeiaiue IOOA. Oea noino?oueny ia o?eueee o?iiaiaiaie?e a in?a c IA
(Coulshed et al., 1970, Benjamin et al.,1994, Wolf et al.,1991). Iiyaa
IOOA o ?aiiueiio iino?ioa?eoiiio ia??iae? anioe?th?oueny c i?aeaeuaiei
?eceeii ea?ae?iaaneoey?ieo aeiaaee?a o iaeaooiueiio iaeaea oaeith ae
i??ith, ye ? iayai?noue OOA (DeCock et al.,1991). Iino?ei? IOOA
i?ecaiaeyoue aei a?eoiiaaiii? aeeeaoaoe?? na?oey, yea ?iiae? noa?
iaiai?ioiith. A?aoo?, caa?iceeaeie iiaeooue aooe ?iceaaee oeaio?aeueii?
aaiiaeeiai?ee i?ae /an ia?ienecio.

Iaaeecia/i?oith i?iaeaiith ? IA, ia aeieth yei? i?eiaaea? 7%
aini?oae?caoe?e ca iaa?aeeeaaeieie iieacaiiyie (Lip et al.,1995) oa
aeecueei 40% aini?oae?caoe?e oa caa?oaiue c i?eaiaeo a?eoi?e (Bialy et
al.,1992; Eooaeianeee, 1992). Naia c IA iia’ycothoue a?ae 7 aei 31% an?o
aino?eo ii?ooaiue iiceiaiai e?iaiia?ao o iaoe??io?a noa?oeo ca 60 ?ie?a
(Zipes, 1984), ui o?eueee aeey NOA neeaaea?, uiiaeiaioa, 75000 iiaeo
aeiaaee?a ia ??e (Singer, 1998). 50-70% c ieo iaoiiaeththoue nia?oue /e
?iaae?aeecaoe?th (Cairms et al.,1991). Cia/aiiy ?ioeo IOOA
iaoiiaeth?oueny, aieiaiei /eiii, iaaaoeaiei aieeaii ia ye?noue aeeooy /e
caa?icith, yeo iiaea ianoe naia aioea?eoi?/ia oa?ai?y. Iaoieia?/ia
/ooeea?noue aei aaaonieo iaiaa??a oa aaeaiiceio iiaea aooe i?e/eiith
o?eaaei? anenoie??, yea iio?aao? ?aai?iaoe?eieo caoiae?a (Pennell et
al., 1994; Slade et al.,1993). Aeineoue a?aeiieie ? a?eoiiaaii? aoaeoe
aeieaoi??a AA aoceiaiai i?iaaaeaiiy o iaoe??io?a c IA oa iai?oanoiei
neiae?iiii WPW. 13,8% iaiiaeyo c IOOA iiie?a? /e ia? cia/i?
oneeaaeiaiiy aiane?aeie oa?aiaaoe/ieo caoiae?a, ni?yiiaaieo ia
i?eieiaiiy ia?ienecio (Sreeram et al.,1990). Iaaacia/iith ? ?
i?io?eaeoe/ia AAO IOOA. A e?oa?aoo?? ?niothoue ee?i?/i? iia?aeiieaiiy
i?i ?icaeoie i?ia?eoi?/ieo aoaeo?a i?e canoinoaaii? iaeaea on?o AAI
(Falk, 1992). Iaea?aeii?oei ? iaoa-aiae?c aeine?aeaeaiue o?i?ae?io o
i?io?eaeoeoe? IA, yeee i?iaeaiiino?oaaa cia/ia i?aeaeuaiiy eaoaeueiino?
na?aae iaoe??io?a, ui eiai io?eioaaee (Coplen, 1990). Ia iaio
aaaeeeaith, i?ae i?ia?eoi?? ? i?iaeaia iia?/ieo aoaeo?a AAI. A?aoo?, EA,
yea a inoaii? aeanyoe??//y noaea iaeaea iniiaiei iaoiaeii e?eoaaiiy
?aaoey?ieo IOOA, oi/ ? aaaaea?oueny aeineoue aacia/iith, i?eianea c
niaith iiaee ia?ae?e oneeaaeiaiue, aeanoeaeo ye eaoaoa?iei iaoiaeai
acaaae?, oae ? aeania EA (Chen et al.,1996).

I?aeoiaee aei e?eoaaiiy IOOA a?ae??ciythoueny iaeaea a eiaeiiio ie?aiiio
caeeaae? ? a?oioothoueny ia no?eueee ia iaoeiaeo aeaieo, ne?eueee ia
aeaniiio aeina?aeia? oiai /e ?ioiai e?ea?y, yeee a?eueo /e iaio
iaiaaeaiee iniaeeainoyie oaoi?/iiai iaeaaeiaiiy oa iaoa??aeueiiai
iinoa/aiiy oiai /e ?ioiai caeeaaeo. Aeai?eoie e?eoaaiiy IA c’yaeeeny
eeoa a inoaii? ?iee (Pratt, 1998; Waldo et al.,1998). I?ioa e aiie ia
iiaeooue aooe oi?aa?naeueieie, ai eiioeiaioe ? iaa?oue e?a?ie iathoue
cia/i? a?aei?iiino? ye o ao?ieia?/i?e no?oeoo?? IA, oae ? a aeina?ae?
canoinoaaiiy oeo /e ?ioeo AAI. Uiaei iaoa?iaeieia?/ieo iaoiaeee
e?eoaaiiy IA, oi /?oe? iieacaiiy aei ieo ua ia aecia/aii. A?aeiinii
?aaoey?ieo IOO neooaoe?y ? a?eueo yniith ? EA noaea aaea noaiaea?oii
e?eoaaiiy a?eueoino? c ieo. I?ioa, ao?eaiiy oeeo iaoiae?a a Oe?a?i?,
aiane?aeie iaaieo aeiiii?/ieo o?oaeiiu?a, yeeo aiia cacia? i?ioyaii
inoaii?o ?ie?a, a?aeaoaa?oueny iaaeoi iia?eueii. Oiio aeooaeueiith ?
ioe?iea aeaniiai aeina?aeo a oe?e aaeoc?. Ua iaei??th i?iaeaiith ?
?nioaaiiy aoi?eiieo oa noiooi?o IOOA, no?oeoo?a ? /anoioa cono??/aiiy
yeeo ia aea/aeeny. Iac’yniaaiei ? ? aieea EA ia i?iaiic iaoe??io?a, ui
iathoue oae?, a iaeeie/i? aeai? c oeueiai i?eaiaeo noia?a/i? (Johna et
al.,1998; Wathen et al.,1993; Tai et al.,1997; Campbell, 1994).

Aeao?i?oe?th ?ao?aeoa?ieo aei e?eoaaiiy a?eoi?e, ye? ii-ia?oa aoee
iniiaiei iieacaiiyi aei EA, ia aecia/aii. A caeaaeiino? a?ae iaoe
aeine?aeaeaiiy a oeth a?oio aeeth/athoue /e ia aeeth/athoue iaoe??io?a,
/ooeeaeo aei ai?iaea?iio. Aei oiai, /anoi iaynii ia/ooeea?noue aei yei?
aeice ai?iaea?iio ? e?eoa???i ?ao?aeoa?iino?.

O./., iacaaaeath/e ia cia/i? oni?oe no/anii? ea?ae?ieia??, a?eoi??
na?oey caeeoathoueny neeaaeiith ee?i?/iith i?iaeaiith (Eooaeianeee,
1992; Campbell, 1994). A?aeiia?aeii, iiaeaeueoa aea/aiiy ?o no?oeoo?e,
ia?aa?ao, a?aeaeaeaieo ?acoeueoao?a oeo /e ?ioeo e?eoaaeueieo no?aoaa?e,
ui nueiaiaei? canoiniaothoueny aeey ?o e?eoaaiiy oyaey?oueny
aeioe?eueiei ? aeooaeueiei., ?aoe?iiae?caoe?y ?nioth/eo i?aeoiae?a aei
e?eoaaiiy IOOA iaiao?aeiith, a i?ia?an o oe?e aaeoc? ia?oey? ia o?eueee
iaaee/i?, aea e nioe?aeueii-aeiiii?/i? aeaiaee.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y ?
o?aaiaioii iaoeiai? ?iaioe ? aea?aeaaii? ?a?no?aoe?? 01960004716
eaoaae?e aini?oaeueii? oa?ai?? ?2 Aei?i?iiao?ianueei? aea?aeaaii?
iaaee/ii? aeaaeai??.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei aecia/aiiy no/anieo
i?aeoiae?a aei oa?ai?? IOOA ia iniia? ioe?iee aoaeoeaiino? oa
aacia/iino? ??ciiiai?oieo oa?iaeieia?/ieo oa iaoa?iaeieia?/ieo
e?eoaaeueieo no?aoaa?e . Aeey oeueiai ieaioaaeiny ae??oeoe oae? caaea/?:

Aecia/eoe no?oeoo?o oa ee?i?/i? iniaeeaino? IOOA

Ioe?ieoe ?acoeueoaoe o?eaaei? AAO a?aeiinii iaoe??io?a c aeayeeie
iiai?ioieie IOOA.

Ioe?ieoe aaciina?aaei? oa a?aeaeaeai? ?acoeueoaoe eaoaoa?ii?
aeano?oeoe?? AeOI o iaoe??io?a c ?aoeei?ieieie IOOaeoi, iiaeeo?eaoe?? AA
i?iaaaeaiiy o iaoe??io?a c AAAO, ?noion-aaeyoe?? o iaoe??io?a c OI oa
aeano?oeoe?? aeoii?/ieo ina?aaee?a o iaoe??io?a c aaoiiaoe/ieie oa
o?eaa?ieie IOOA.

Aea/eoe aieea EA AA c’?aeiaiiy ia ye?noue aeeooy iaoe??io?a c IA.

Aecia/eoe yeith i??ith iayai?noue IA/OI o iaoe??io?a c AAO oa IO aieeaa?
ia a?aeaeaeai? ee?i?/i? ?acoeueoaoe EA inoaii?o.

Ioe?ieoe a?aeaeaeai? ?acoeueoaoe ?noion-aaeyoe?? o iaoe??io?a, ye?
ii?yae c OI iathoue IA, ye ae?oao a?eoi?th.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. 1) Aia?oa aea/aii iniaeeaino?
o?aaeaiiy ei?iia?iiai ?onea o iaoe??io?a c ?ON oa IA oa ia ciaeaeaii
ca’yceo inoaiiuei? c ia?aaena?aeiith ?oai??th. 2) Aia?oa
i?iaeaiiino?iaaia aoaeoeai?noue iecueeiaia?aaoe/ii? aioo??oiueina?oeaai?
EA IA o iaoe??io?a c i?aeaeuaiei o?ainoi?aeaeueiei ?iiaaeainii, a yeeo
ciai?oiy EA aoea iaaoaeoeaiith. 3) Aia?oa i?iaaaeaii ii??aiyeueiee
aiae?c ?acoeueoao?a canoinoaaiiy aeey EA IA na?aaei?o oa aenieeo aeic
ai?iaea?iio. 4) Aia?oa i?iaeaiiino?iaai? ia?aaaae i?io?eaeoe/ii? oa?ai??
IA c o?aooaaiiyi ?? ee?i?ei-iaoiaaiaoe/iiai oeio. 5) Aia?oa iiaeaii
?acoeueoaoe o?eaaei? oa?ai?? ai?iaea?iiii o i?aeo?eioth/?e aeic? 300-400
ia\aeia. a a?oi? iaoe??io?a c iiai?ioiith IA. 6) Aia?oa i?iaaaeaii
eiio?ieth?ia aeine?aeaeaiiy aoaeoeaiino? EA AA c’?aeiaiiy a a?oi?
iaoe??io?a c ?acenoaioiith aei iaaeeeaiaioicii? oa?ai?? IA. 7) Aeyaeaii
oaeoi?e, ui iaoiiaeththoue iiyao IA i?ney EA OI. 8) Aeyaeaii oaeoi?e
?eceeo ?aoeeaeea?a AAAO i?ney iiaeeo?eaoe?? AA i?iaaaeaiiy o iaoe??io?a,
a yeeo i?ioeaaeo?a aeciaia oe?eeii oni?oiith ca no/anieie e?eoa??yie.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. 1) Cai?iiiiiaaii aeai?eoie
e?eoaaiiy IA. 2) I?iaeaiiino?iaaii iaaeioe?euei?noue canoinoaaiiy
aenieiaia?aaoe/ii? aioo?eoiueina?oeaai? EA. 3) Iieacaii aenieo
aoaeoeai?noue ? aacia/i?noue iecueeiaia?aaoe/ii? aioo??oiueina?oeaai? EA
a niaoeeo?/ieo a?oiao iaoe??io?a. 4) I?aeoaa?aeaeaii aoaeoeai?noue ?
aacia/i?noue iaaaioaaeaiiy 22 a ai?iaea?iio aeey EA o?eaaei
ia?nenooth/i? IA. 5) Cai?iiiiiaaii noaie e?eoaaiiy aaaonii? IA. 6)
I?iaeaiiino?iaaii aoaeoeai?noue ? aacia/i?noue canoinoaaiiy EA aeey
e?eoaaiiy IOOA. 7) I?iaeaiiino?iaaii aeioe?euei?noue EA IOOA o
iaoe??io?a, a yeeo, o ca’yceo c iayai?noth a ieo na?oeaai-noaeeiii?
iaoieia??, iaiao?aei?noue iino?eii? oa?ai?? aaoa-aeieaoi?aie /e
aioaaii?noaie eaeueoe?th caa??aa?oueny e i?ney ae?i?iaoe?? a?eoi??. 8)
Aea/aii /anoioo ? no?oeoo?o oneeaaeiaiue EA. 9) I?iaaaeaii ii??aiyeueiee
aiae?c ??ciiiai?oieo iaoiaeee iiaeeo?eaoe?? AA i?iaaaeaiiy a iaoe??io?a
c AAAO ? cai?iiiiiaaii iiao iaoiaeeeo. 10) C’yniaaii, ui a iniia?
?acenoaioiino? IA aei AAO eaaeeoue ?nioaaiiy aeoeaieo
caiaeueii-aeeno?io?/ieo i?ioean?a a i?iea?ae?, iaoiaaiaoe/ia oa?ai?y
yeeo ? aei?aaaeai?oith ca AAO.

?acoeueoaoe ?iaioe ai?iaaaeaeaii a i?aeoeeo ?iaioe Aei?i?iiao?ianueeiai
iaeaniiai ea?ae?ieia?/iiai aeeniaina?o, Aei?i?iiao?ianueeiai iaeaniiai
ae?aaiinoe/iiai oeaio?o, Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii?
aeaaeai??, Iaeanueei? i?nueei? e?ea?i? oaeaeei? aeiiiiiae. Io?eiaii 2
iaoaioe ia aeiao?ae ? 5 na?aeioeoa i?i ?aoe?iiae?caoi?nuee? i?iiiceoe??.
Iienaiiy aeiaoiae?a aoee aeeth/ai? aei Aaeocaaiai ?a?no?o Iiaiaaaaeaiue
1998 ?. Aeaeaii ?ioi?iaoe?eiee eenoie.

Iniaenoee aianie caeiaoaa/a. Aaoi? a?aa o/anoue a on?o i?ioeaaeo?ao
eaoaoa?ii? aaeyoe?? oa aeaeo?e/ii? ea?ae?iaa?n??, iniaenoi i?ia?a 1\4
i?ioeaaeo? /a?acno?aaio?aeii? noeioeyoe??, a?eueo?noue aaeia?aiiao??e.
E?eoaaiiy iaoe??io?a c ieaioeeaith a?eoi??th ai?iaea?iiii oa
aeeciie?aieaeii oaeiae cae?enithaaeiny aaoi?ii iniaenoi. ?aea?
iaoaioiaaieo a?aee?eoue, iioae?eiaaieo o ni?aaaoi?noa?, iaeaaeaoue
aaoi?ia?. Aiae?c, ocaaaeueiaiiy, noaoenoe/ia ia?iaea io?eiaieo
?acoeueoao?a oa i?aeaioiaea iaoa??ae?a aei ioae?eaoe?? aaoi? i?iaiaeea
naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue, ui
aeeth/aii aei aeena?oaoe??, ii?eethaeiai? ia Anana?oiueiio neiiic?oi? c
aeaeo?io?c?ieia?? oa noeioeyoe?? na?oey a Aa?e?i? (1999), i?aeia?iaeieo
eiia?anao Ea?aeeinoei’95 oa Ea?aeeinoei’98 o Naieo-Iaoa?ao?c?, 3-io
I?aeia?iaeiiio neiiic?oi? “Aritmija Lietuva’96” o Eeaeiaae?, 57-io
eiia?an? Iieuenueeiai oiaa?enoaa ea?ae?ieia?a o Aa?oaa? (1995), 2-io
Eiia?an? ea?ae?ieia?a Oeaio?aeueii? Ac?? o Aeiao? (1995), 16-iio c’?cae?
I?aeia?iaeiiai oiaa?enoaa a?ia?oaic?? a Aeacai (1996), 17-iio eiia?an?
?a?iiaenueeiai oiaa?enoaa ea?ae?ieia?a o A??i?iaai? (1996), 6-iio
Na?oiaiio eiia?an? ii na?oeaa?e ?aaa?e?oaoe?? o Aoaiin-Ae?an?, 6-iio
eiia?an? Na?oiai? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa a
Iaean? (1996), 4-iio Na?oiaiio eiia?an? c na?oeaai? iaaeinoaoiino? o
??onaeei? (1996), 8 oa 9-iio ?a?iiaenueeeo c’?caeao ii a?ia?oaic?? o
I?eai? (1997,1999), 13-iio Na?oiaiio eiia?an? ea?ae?ieia?a o
??i-aea-AEaiae?i (1998), 11-io c’?cae? Na?aaeiueicaiiiii?nueei?
anioe?aoe?? ea?ae?ieia?? oa na?oeaai? o??o?a?? o Iioiaeuea (1998),
tha?eaei?e eiioa?aioe??, i?enay/ai?e 100-??//th iaaee/iiai oi?aa?neoaoo
?i. Iaaeiaa “I?ia?an ? e?eoaaiiy na?oeaai-noaeeiieo caoai?thaaiue” o
Naieo-Iaoa?ao?c? (1997), Iaoeiai-i?aeoe/i?e eiioa?aioe??
aei?i?iiao?ianueei? iaaee/ii? aeaaeai??, i?enay/ai?e aeanyoe??//th
aaa??? ia *i?iiaeeuenuee?e AAN (1996), 3-e i?aeia?iaei?e eiioa?aioe??
“O?aioe?y oa Oe?a?ia, iaoeiai-i?aeoe/iee aeina?ae o ae?aeic?
iaoe?iiaeueieo eoeueoo?” o Aei?i?iiao?ianueeo (1996), 2,3, 4 oa 6-e
eiioa?aioe?yo Oe?a?inueei? anioe?aoe?? na?oeaai-noaeeiieo o??o?a?a
(1994,1995,1996,1998), Oe?a?inuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? c
i?aeia?iae-iith o/anoth “Aeooaeueiua aii?inu iaiaaeeeaiaioiciiai ea/aiey
caaieaaaiee i?aaiia aeuoaiey, na?aea/ii-ninoaeenoie e ia?aiie nenoaiu” o
sseo? (1996), 1 Iaoe?iiaeueiiio c’?cae? oa?iaeieia?a Oe?a?ie o Iieoaa?
(1995), iaoeiai-i?aeoe/i?e eiioa?aioe?? Aei?i?iiao?ianueeiai iaaee/iiai
?inoeoooo (1993), 1 Oe?a?inuee?e eii-oa?aioe?? c iaa?aeeeaaeii?
aeiiiiiae o Iaean? (1993), ia can?aeaiiyo Aei?i?iiao?ianueeiai iaeaniiai
oiaa?enoaa ea?ae?ieia?a (1996,1997), ia i?aeeaoaae?aeueiiio can?aeaii?
Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai?? (1999),
ia?aaeaoanoaoe?eieo eo?nao ea?ae?ieia?a (1997) oa e?ea??a
ooieoe?iiaeueii? ae?aaiinoeee (1997).

Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaai? o 19 noaooyo o
i?ia?aeieo iaoeiaeo aeo?iaeao, 5 noaooyo o ?ioeo iaoeiaeo aeo?iaeao oa
ca??ieeao iaoeiaeo i?aoeue,45 iaoa??aeao ? oacao eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 352
noi??ieao iaoeiiieniiai oaenoo oa neeaaea?oueny c anooio, ?noi?e/ii?
aeia?aeee, iaeyaeo e?oa?aoo?e, iaoa??ae?a ? iaoiae?a, aeao?i?oe?e, 21
?icae?eo, i?enay/aiiai ?acoeueoaoai ?iaioe ? ?o iaaiai?aiith, aeniiae?a
i i?aeoe/ieo ?aeiiaiaeaoe?e, ia? 53 oaaeeoe? ? 21 ?enoiie. Ia?ae?e
e?oa?aoo?e i?noeoue 26 a?o/eciyieo oa 650 ?iicaiieo aeaea?ae.

iniiaiee Ci?no aeena?oaoe??

Iaoa??aee aeine?aeaeaiiy. Iiioeyoe?th aeine?aeaeaiiy neeaee 2028
iaoe??io?a c ??ciiiai?oieie IOOA. ?o oa?aeoa?enoeeo iiaeaii o oaaeeoe?
1. Aei oe??? iiioeyoe?? oa?eoei 1688 iaoe??io?a, ye? aoee ianoaaeai? o
Aei?i?iiao?ianueeiio iaeaniiio ae?aaiinoe/iiio oeaio??, oa 340
iaoe??io?a, ye? aoee ianoaaeai? o iaaee/i?e ee?i?oe? oi?aa?neoaoo
Aaa?aa?aea-Ea?ea e i?ieoee ?iaaceaia AOAe c /e aac EA o eaai?aoi???
eaoaoa?ecaoe?? na?oey. E??i oiai, aeey aiae?co /anoioe cono??/aiiy
??cieo eieae?caoe?e AeOI aeei?enoaii iaoa??ae 142 EA, ui aoee i?iaaaeai?
a oeueiio caeeaae? i?ioyaii 1995-1997 ?ie?a, a aeey aiae?co /anoioe
cono??/aiiy IA o iaoe??io?a c EAA- aeieoiaioiaaiei ei?iia?iei neea?icii
— ?acoeueoaoe EAA 3220 iaoe??io?a, ye? i?ieoee oea ianoaaeaiiy
i?ioyaii 1997-1998 ?ie?a. Aeey ae?aaiinoeee a?eoi?e ?

Oaaeeoey 1.

Ee?i?/ia oa?aeoa?enoeea iiioeyoe?? aeine?aeaeaiiy

Iieacieee\a?eoi?y IA OI IO AAAO AAOaeoi Anueiai

E?euee?noue 413 596 55 365 310 2028

Aeiey /ieia?e?a 272 (65,8%) 411 (72,2%) 22

(40%) 177 (48,5%) 195 (62,9%) 1077 (53,1%)

A?e (?ie?a) 68(26 64(19 44(17 53(16 34(24 57(31

Iino?eia a?eoi?y (%) 90

(21,8%) 507 (85,1%) 7 (12,7%) 4

(1,1%) — 681 (33,6%)

Caoai?thaaiiy

?ON 116 (28,1%) 119

(20%) 13 (23,6%) 39

(11%) 23

(7,4%) 310 (15,3%)

?aaiaoeci 29 (7%) 6 (1%) — — — 35 (1,7%)

I?iea?aeeo 4 (1%) — — — — 4 (0,1%)

Iinoi?iea?aeeoe/iee ea?ae?ineea?ic 9

(2,2%) 2

(0,3%) 1 (1,8%) 1

(0,3%) — 13

(0,6%)

AEII, ?EII 4 (1%) — —

1 (0,3%) 5 (0,2%)

AeEII 24 (5,8%) 1 (0,2%) — 1(0,3%) 1 (0,3%) 27 (1,3%)

OAN oa noaie i?ney ?o ei?aeoe?? 2 (0,5%) 12 (2%) 3 (5,5%) 3 (0,8%)
1 (0,3%) 21 (1%)

AA 183 (44,3%) 175 (29,4%) 12 (21,8%) 63 (17,3%) 44 (14,2%) 477
(23,6%)

A?ia?oe?aic 8 (1,9%) 2 (0,3%) — — — 10 (0,5%)

Oeoe?iaee ae?aaao 15 (3,6%) 19(3,2%) 1(1,8%) 5(1,4%) — 40 (2%)

Iaee??iiy 44 (10,7%) 63 (10,6%) 3 (5,5%) 20

(5,5%) 9 (2,9%) 139 (6,8%)

Ceiaaeeaaiiy aeeiaieai 45

(10,9%) 33 (5,5%) 1 (1,8%) 6 (1.6%) — 85 (4,2%)

Nenoaii? caoai?thaaiiy niieo/ii? oeaieie 1 (0,2%) — — — — 1 (0,05%)

OICE 12 (2,9%) 22 (3,7%) 3 (5,5%) 4 (1,1%) 2 (0,6%) 43 (2,1%)

?io? 6 (1,5%) 6 (1%) 1(1,8%) — — 13 (0,6%)

Iaia 114

(27,6) 229 (38,4%) 27 (49,1%) 236 (64,7%) 269 (86,8%) 805 (39,7%)

noai?a, ui c ieie anioe?thaaeeny, aeei?enoiaoaaeeny
aeaeo?iea?ae?ia?ao?y, aeiaiaa iii?oi?oaaiiy, aaeia?aiiao??y, ia?iaaceaia
AOAe na?oey iaoiaeii *NAN oa ?iaaceaia AOAe, EAA oa aaio?eeoeia?ao?y,
AoiEA, eaai?aoi?i? oanoe. A e?eoaaii? iaoe??io?a canoiniaoaaee AAI, ye?
i?ecia/aeeny aii??e/ii /e ia iniia? ?acoeueoao?a aeaeo?io?c?ieia?/iiai
oanooaaiiy, aeaeo?i?iioeuenio oa?ai?th, ?aae?i/anoioio eaoaoa?io
aaeyoe?th. ?acoeueoaoe canoinoaaiiy e?eoaaeueieo iaoiaeee aea/aeeny a
?ao?iniaeoeaieo (i?iiaoaiii i?ioe aeeciie?aieaeo a i?io?eaeoeoe? IA, IA
o iaoe??io?a c ?ON, no?oeoo?a IOOA), i?iniaeoeaieo iaeiio?ieueiaaieo
(aeeciie?aieae o iaoe??io?a c aaaoniith IA, ?acoeueoaoe ANEA IA oa EA
IOOA), ci?oaieo (iniaeeaino? ia?aa?ao IOOA), ?aiaeii?ciaaieo
(oa?iaeieia?/ia EA 12,6 a i?ioe 22,4 a ai?iaea?iio, aeeciie?aieae i?ioe
i?iiaoaiiio a i?io?eaeoeoe? i?/ii? IA), a?aee?eoeo eiio?ieueiaaieo (EA
AA c’?aeiaiiy i?ioe oa?iaeieia?/ii? oa?ai?? o iaoe??io?a c ?ao?aeoa?iith
IA) aeine?aeaeaiiyo. Aiae?c aoaeoeaiino? AAO i?iaiaeeany ia iniia?
intention-to- treat. ?acoeueoaoe iiaeaii ye na?aaei? ( noaiaea?oia
a?aeoeeaiiy /e /anoioa aeyaeaiiy o a?aenioeao. Aeey oi?aa??aioieo
ii??aiyiue eaoaai??eieo aa??aio canoiniaoaaee oano Fisher, aeey cia/aiue
— iaia?iee oano Student. Aeey ?aeaioeo?eaoe?? aeinoia??ieo iacaeaaeieo
oaeoi??a ?eceeo aacaeuei? ee?i?/i? oa i?ioeaaeo?aeuei? aa??aioe aoee
iine?aeiaii ioe?iai? ?aa?aneaiei oanoii Cox. Iiaeeea?noue aeaeeaaiiy aac
a?eoi?? oa iiaeeea?noue ?? iiai?io?a ?ic?aoiaoaaee ca iaoiaeii Kaplan oa
Mayer. Aeinoia??iei aaaaeaee cia/aiiy p<0,05. ?acoeueoaoe oa ?o iaaiai?aiiy. Ee?i?/i? iniaeeaino? IOOA. Iae/ano?oeie caoai?thaaiiyie a iiioeyoe?? aeine?aeaeaiiy aoee AA oa ?ON, ye? naiino?eii /e ?acii aoee aeyaeai? a?eueo i?ae o 20% iaoe??io?a. ?ON ae?aaiinooaaee o 29% oai?eo c IA ?ao?iniaeoeaiee aiae?c 3220 caeeth/aiue EAA cana?ae/ea, ui iino?eio IA iaee 74 (2,3%) iaoe??ioe. C ieo o?aaeaiiy oi/ ae iaei??? a?ioeaai? noaeeie aeyaeaii o?eueee a 49 (66,2%). Iai?ioe, na?aae iaoe??io?a ?c N? ?ON iaee 2784 (88,5%). Ioaea, /anoioa cono??/aiiy IA na?aae iaoe??io?a ?c aeiaaaeaiith ?ON neeaea 1,7% (49 c 2833) ? aoea iaioith (p<0,02) ca oaeo na?aae iaoe??io?a aac ?ON - 6,5% (25 c 387). Ii??aiyiiy oai?eo ia ?ON c IA oa aac ia? (oaaeeoey 2) ia aeyaeei iniaeeainoae o?aaeaiiy iaeiath/eo oa ?o ia?aaena?aeieo a?eie a iaoe??io?a ?c IA. Inoaii?, i?ioa, /ano?oa iaee ieo?aeueio ?aao?a?oaoe?th, o?ueionoaeeii? o?aaeaiiy oa cieaeaio o?aeoe?th aeeeaeo e?aiai oeoii/ea. Ioaea, ciao?aeee na?ae/aoue, ui IA ??aeei cono??/a?oueny a iaoe??io?a ?c EAA- aeieoiaioiaaiith ?ON, a a ?? aaiac? o iaoe??io?a oe??? a?oie nenoie?/ia aeenooieoe?y i?iea?aea iiaea aooe aaaeeea?oith ca o?ii?/io ia?aaena?aeio ?oai?th. Aea/aiiy oiia, a yeeo aeieeaee iaiaaee IOOA iieacaei, ui a a?eueoino? aeiaaee?a aiie aeieeaee oe?eeii ianiiae?aaii. O? /e ?io? i?iae?iie a?ae/oaaee eeoa Oaaeeoey 2. ?acoeueoaoe EAA oa aaio?eeoeia?ao?? IA N? E?euee?noue 49 103 aeiey /ieia?e?a 35 (71,4%) 73 (70,9%) a?e (?ie?a) 64,8(8,4 61,3(9,9 E?euee?noue o?aaeaieo a?ioeaaeo a?oa??e 1 12 (24,5%) 30 (29,1%) 2 22 (44,9%) 52 (50,5%) 3 15 (30,5%) 21 (20,4%)* Aaiiaeeiai?/ii cia/i? noaiice I?aaa ei?iia?ia a?oa??y 9 (18,4%) 21 (20,4%) Iaeiath/a a?eea e?ai? ei?iia?ii? a?oa??? 18 (36,7%) 32 (31,1%) Anueiai iaeiath/? 21 (42,9%) 47 (43,5%) Noaiice aei a?aeoiaeaeaiiy ia?aae- na?aeieo a?eie 14 (28,6%) 27 (25%) Ieo?aeueia ?aao?a?oaoe?y 10 (20,4%) 11 (10,2%)* O?aeoe?y aeeeaeo <45% 27 (55,1%) 20 (18,5%)** I?ei?oee: *p<0,05; ** p<0,002 7% iaoe??io?a c AAO, 11,6% iaoe??io?a c IA, 4,7% iaoe??io?a c OI ? 10,4% c oeo, ye? iaee IO (IAe aeey an?o). A?ae 17 aei 60% iaoe??io?a o ??cieo a?oiao iiooaaee, ui iiyao i?enooi?a i?iaieo? o?ce/ia iaaaioaaeaiiy /e/oa aiioe?eiee no?an. I?ioa, ?aoaeueia iieooaaiiy c’ynoaaei iaiaeii??aei?noue oe??? i?aea?oie. A 88% iaoe??io?a c AAO, ye? ii?aeioaaee iaiaaee a?eoi?? c oeeie noaiaie, ? a 75,2% iaoe??io?a c IA/OI iaiaaee ia ii/eiaeeny ia oiee? iaaaioaaeaiiy, a eeoa a?ae?aco /e oaeaeei i?ney eiai i?eieiaiiy. Iai?ioe, o 77% (37 c 48) iaoe??io?a c IO ia?ienecie iiaee aeieeaoe ia oiee? iaaaioaaeaiiy/iai?oaeaiiy. A?aei?ii?noue aoea aeniei aeinoia??iith (11,9% ? 24,8% i?ioe 77,1%, p<0,0001 i p<0,001, a?aeiia?aeii). C 37 oeeo iaoe??io?a o 32 IO aoea aeoii?/iith. 91,1% iaoe??io?a c AAO iiooaaee, ui a?eoi?y ii/eia?oueny o ca’yceo c ??ceith ci?iith iieiaeaiiy o?ea. Iai?ioe, na?aae iaoe??io?a c ia?aaena?aeieie oao?a?eoi?yie oaeee oaiiiai aoei a?aecia/aii eeoa a 17%. Iaiaaee, ui ii/eiaeeny i?ae /an i?/iiai nio, iaee eeoa 0,4% iaoe??io?a c AAO ?, uiiaeiaioa 76,2% iaoe??io?a c IA (p<0,001). Inoaiiy aeyaeeany iaea?eueo caeaaeiith a?ae iaoai?ieia?/ieo ci?i. ?? oee?eaaei? iaoa?ie aoee a oe?e a?oi? ??ciini?yiiaaieie. Ee?i?/i? iniaeeaino? ii/aoeo IA aeicaieeee ?iciiae?eeoe iaoe??io?a ia aeae?eueea a?oi. O 69 c 323 (21,4%) iaoe??io?a c iiai?ioiith IA ianooie, aeieeaee ia?aaaaeii /e aeeeth/ii aii/? /e oaa/a?? i?ney aaeeaaiiy ?ae? (/anoi ia?a?aeaiiy). IA a oeeo iaoe??io?a i?eiee ia aeieeaea ia oiee? o?ce/ii? aeoeaiino? /e aiioe?eiiai no?ano, aea iiaea c’yaeyoeny a ia??iae? ?aeaenaoe??. Oaea ee?i?/ia ea?oeia na?ae/eea, ui iniiaiei iaoiaaiaoe/iei oaeoi?ii a aaiac? IA o oeeo iaoe??io?a aoea a?ia?aaaioii?y. Nooi a?ia?aae?aia?a?/iee oei aoei ?aeaioeo?eiaaii o 45 (13,9%) iaoe??io?a. Ia?ienecie aeieeaee a?aioe? (i?ney i?ineiaiiy), i?e o?ce/iiio /e aiioe?eiiio iaaaioaaeaii?. Ii/aoeo ia?ieneci?a ia?aaeoaaee i?enei?aiiy N? oa//e aeno?anenoie?y. Aea ae o a?eueoino? iaoe??io?a aoee iayai? iaeaeaa oeie ia?ieneci?a (54,8%) /e ca’ycie AIN c ieie ia aoa oaeei yaiei (10,3%). Iaoe??ioe, a eiai aeae?eeoe ee?i?ei-iaoiaaiaoe/iee oei ia aoei iiaeeeaei aoee noa?oeie ca iaoe??io?a c /?oeeie oeiaie, /ano?oa iaee i?aai?/io iaoieia?th na?oey oa ??aeoa AA (oaaeeoey 3). E??i oiai aeiey ae?iie o aaaoni?e a?oi? aeinoia??ii ia?aaeuoaaea oae? a ?ioeo. 97 (46,4%) iaoe??io?a ci?oaii? a?oie cacia/aee, ui o ia?o? ?iee ?nioaaiiy IA, inoaiiy aoea ia?aaaaeii i?/iith /e aeieeaea aaa/a?? i?ney cia/iiai o?ce/iiai /e/oa ineoiaiioe?eiiai iai?oaeaiiy. Eeoa a iiaeaeueoiio i?e?aeiaeeny iaiaaee, ye? ca oa?aeoa?ii iiaee aooe ?icoe?iai? ye aae?aia?a?/i?. 59 (60,8%) c oeeo iaoe??io?a cacia/eee, ui inoaii? c’yaeeeny i?ney iiyaeaiiy AA, noaiiea?ae??, ia?aianaiiai ?ioa?eoo i?iea?aea /e ii?ooaiiy iiceiaiai e?iaiia?ao. Ia oe?e i?aenoaa? oyaey?oueny aeoaea a??ia?aeiei, ui oe? oeie iiaeathoue niaith eeoa aoaie ?icaeoeo oa noaiiaeaiiy IA, uiiaeiaioa, a iaoe??io?a c ?ae?iiaoe/iith IA. Oaaeeoey 3. Ii??aiyeueia oa?aeoa?enoeea a?oi iaoe??io?a c ??cieie iaoiaaiaoe/ieie oeiaie IA Iieacieee\a?eoi?y Aaaonia IA Aae?aia?a?/ia IA ?io? E?euee?noue 69 45 209 Aeiey /ieia?e?a 33 (47,8%) 32 (71,1%)* 152 (72,7%)* A?e (?ie?a) 59(13 61,8(11 71(14*( I?aai?/ia na?oeaaa iaoieia?y 7 (9,2%) 11 (20,4%)( 104 (49,7%)*( AA 27 (49,3%) 27 (60%) 67 (32,1%)*( I?ei?oee: 1) ( aeinoia??ia a?aei?ii?noue a ii??aiyii? c aaaoniith a?oiith 2) *aeinoia??ia a?aei?ii?noue a ii??aiyii? c aae?aia?a?/iith a?oiith No?oeoo?a IOO A?eoi?? a iaoe??io?a c AeOI. O 13 (2,2%) iaoe??io?a AeOI aoee ?aeaioeo?eiaai? ye aieieia Macheim, a ?ioeo - Kent. I?aa? oa e?a? AeOI (46,7% oa 53,3%), eieae?ciaai? o a?eueieo no?ieao ? o?, ui ciaoiaeeeeny o ia?aoeioe? /e a?ey ia? (49,8% oa 50,2%) iaee iaeiaeiaa i?aaenoaaieoeoai. I?eoiaai? AeOI /ano?oa ca o?, ui i?iaiaeeee aioaa?aaeii, aoee e?aeie (64,2% i?ioe 50,8%, ?<0,02). Oey a?aei?ii?noue aoea iaoiiaeaia, aieiaiei /eiii, a?eueoith /anoioith AeOI, ui ?icoaoiaoaaeeny o a?euei?e no?ioe? (56,6% i?ioe 27,8%, ?<0,001). Iai?ioe, eieae?caoe?y o a?euei?e no?ioe? i?aaiai oeoii/ea aeyaeeany aeey i?eoiaaieo AeOI iaoeiiaith ? iinooiaeany oae?e a a?oi? c neiae?iiii WPW (7,5% i?ioe 19,2%, p<0,001). Acaaae?, ?aa?iiii, aea AeOI cono??/aeeny iae/ano?oa, aoea caaeiy no?iea na?oey - ia ia? i?eiaei 50,9% an?o aeiaaee?a. Eaoaioiee oa i?eoiaeee neiae?iie WPW aeyaeyeeny c iaeiaeiaith /anoioith ? iaoiiaeee 22% an?o AeOI, ui i?iaiaeeee aioaa?aaeii. Eeoa a 4,2% aeiaaee?a neiae?iio WPW AeOI i?iaiaeeee o?eueee a iaeiiio iai?yieo. Aeaa AeOI iaee 7 c 320 iaoe??io?a (2,2%), ye? i?ieoee EA. Iae/ano?oith (78,1%) a?eoi??th aoea i?oiae?iiia AAO. 18,1% iaoe??io?a c neiae?iiii WPW iaee eeoa IA. E??i oiai no?eeo IA aoei ni?iaieiaaii o 95 c 494 (19,2%) iaoe??io?a c AAO. Oaeei /eiii, a a?oi? iaoe??io?a c AeOI ?iaeoeoe?y no?eei? IA aoea iiaeeeaith a 31,2% (181 c 580) aeiaaee?a. *anoioa ?? aeyaeaiiy o iaoe??io?a c neiae?iiii WPW ia a?ae??ciyeany a caeaaeiino? a?ae oeio (?iaaceaia /e ia?iaaceaia) AOAe: a?aeiia?aeii 31,5% (101 c 320) oa c 30,8% (80 c 260), IAe. IA /ano?oa i?iaieoaaeany o iaoe??io?a c neiae?iiii WPW (59,5% i?ioe 10,4% a oeo, ye? iaee iioiaai? AeOI, p<0,001), aoea iaeiaeiai /anoith o iaoe??io?a c neiae?iiii WPW ? i?oiae?iiiith IOOaeoi o oeo, ui iaee aioeae?iiio (21,9% oa 19,5% a?aeiia?aeii, IAe). Iaoe??ioe ?c i?eoiaaieie AeOI iaee ?? ??aeoa ca oeo, c i?oiae?iiiith IOOaeoi i?e neiae?ii? WPW (10,4% i?ioe 21,9%, p<0,01). Ii??aiyiiy a?oi iaoe??io?a c IA oa aac ia? ca eieae?caoe??th AeOI ia aeyaeei aeinoia??ii? a?aei?iiino?. A a?oi? c IA cia/ii ia?aa?eueooaaea aeiey /ieia?e?a (82,6% i?ioe 30,8%, p<0,0001) ? /anoioa aeyaeaiiy i?aai?/ii? iaoieia?? na?oey. Oe? iaoe??ioe aoee noa?oeie 37±17 i?ioe 32±14, p<0,05) ? iaee iaioee oeeee oao?ea?ae?? (321±89 i?ioe 339±48, p<0,05). AAAO iaee 14 iaoe??io?a c AeOI. AA aoceia? oao?ea?ae??. Na?aae 365 iaoe??io?a c AAAO 7 (1,9%) iaee aeoii?/io aoceiao AAO. ?io? 358 aoee iaoiiaeaieie iaoai?ciii reentry. O 27 (7,5%) c oeeo inoaii?o iaoe??io?a i?iaieoaaeeny aoeiia? AAAO: slow-slow o 16 (59,3%) oa fast-slow - o 11 (40,7%). O /ioe?ueio iiaeeeai aoei ni?iaieoaaoe iaeaea? aoeiia? AAAO oa ua o?i? iaee slow-fast oa fast-slow oao?ea?ae??. Aoeiia? AAAO iaee o?eaae?oee ca oeiia? oeeee oao?ea?ae?? (382(59 i?ioe 327(71 in, p<0,02). O?eaae?noue oeeeeo fast-slow oa solow-slow oao?ea?ae?e ia a?ae??ciyeany (378(41 i?ioe 381(67 in, IAe). Acaaae?, na?aaei?e oeeee AAAO neeaa 375(88 in. Iia?euei? oao?ea?ae?? c oeeeeii o?eaae?noth (500 in ca?a?no?iaaii o 17 (4,7%) iaoe??io?a. Iino?eio /e iino?eii-iiai?ioio ?aoeei?ieio AAAO iaee oanoa?i in?a (1,6%). I?ia?aiiaaia oa//e i?enei?thth/a noeioeyoe?y aeicaieeea aeyaeoe iciaee iiaeiaaeiuei? aeenioe?aoe?? AA c’?aeiaiiy o 339 (92,9%) iaoe??io?a c AAAO. C oeeo inoaii?o eeoa aioaa?aaeio aeenioe?aoe?th iaee 283 (83,5%), ?ao?ia?aaeio - 25 (7,4%), a iaio iai?yieao - 31 (9,1%). A?eueo ca iaeei “no?eaie”o AA i?iaaaeaii? aeyaeaii o 41 (12,1%) iaoe??ioa. Aioaa?aaeiee “no?eaie” neeaa 112(76 (50-230) in, ?ao?ia?aaeiee - 109(83 (50-230) in, IAe. O 96 (26,3%), iaoe??io?a AAAO niieo/aeany c ?ioeie oao?a?eoi?yie: oeoii/eiaa oao?ea?ae?y - 4, IA - 78 (21,4%), IOOaeoi - 14 (3,8%). Ioaea iae/ano?oei aoei niieo/aiiy c ia?aaena?aeieie oao?a?eoi?yie. Iaoe??ioe c IA aoee noa?oeie (58(17 i?ioe 49(2 ?., p<0,02), /ano?oa iaee i?aai?/io iaoieia?th na?oey (34,6% i?ioe 16,4%), a oeeee oao?ea?ae?? a ieo aoa ei?iooee ca oaeee a iaoe??io?a eeoa c AAAO (354(81 i?ioe 381(100, p<0,01). Ni?aa?aeiioaiiy /ieia?ee /ae?iee aoei a oe?e a?oi? iaeaea 1:1. Iiaeiaaeiy aeenioe?aoe?y AA c’?aeiaiiy o iaoe??io?a aac AAAO. Na?aae 288 iaoe??io?a, ye? ia iaee AAAO oa IOOaeoi iciaee iiaeiaaeiuei? aeenioe?aoe?? aoei aeyaeaii o 73 (25,3%). Oeae iieaciee aoa iaeiaeiaei o iaoe??io?a c AeOI (28,1%), oeo, ye? i?ioiaeeee AOAe c i?eaiaeo OOA (24,2%) oa ?ioeo ca AAAO IOOA (26,6%). O??iio?iiy ia?aaena?aeue. Na?aae iaoe??io?a c oeiiaei OI 62% iaee counterclockwise, 12,5% - clockwise, 25,9% - iaeaeaa. A 11% iaoe??io?a ii?yae c ee?i?/iei oeiiaei OI i?iaieoaaeiny aoeiiaa. IA ?a?no?oaaeany a 50,8% iaoe??io?a ?c aoeiiaei OI oa 26 (23,2%) c oeiiaei (p<0,001). Aiia aoea iaeiaeiai /anoith ciao?aeeith a iaoe??io?a c clockwise oa counterclockwise OI (a?aeiia?aeii 37,2 oa 39,8%, IAe). E?eoaaiiy IOOA Aeaeo?e/ia EA IA. ?ice?eaath/e oeyoe cieaeaiiy ii?iao aeaeo?e/ii? EA oa i?aeaeuaiiy ?? aoaeoeaiino?, aea/aii iiaeeeaino? ANEA. 16 iaoe??io?a c ia?nenooth/ith IA o?eaae?noth 7,6(3,9 i?nyoe?a (OA 39(13%; eean NI 2,8(1,3; ae?aiao? e?aiai ia?aaena?aey 5,8(1,3 ni) i?ieoee aioo??oith EA ?ic?yaeii iiiioaciiai no?oio ianeio?ii?ciaaiiai c coaoeai R, yeee iaiineany i?ae aioo??oiueina?oeaaei aeaeo?iaeii oa oi?aeaeueiith ieanoeiith. Ie a?iioacoaaee, ui aenieiaia?aaoe/ia ANEA iiaea aooe aacia/i?oith ?, iiaeeeai, aoaeoeai?oith ca ciai?oith o iaoe??io?a c i?aeaeuaiei ?eceeii oneeaaeiaiue ? iaoni?oo inoaiiuei?. N? aoei a?aeiiaeaii 13 (81,3%) iaoe??ioai. Ii??a aeao?a?eeyoe?? oa caaaeueia aia?a?y neeaee, a?aeiia?aeii, 147(41 ? 256(68 Aeae. Aeaii iaoe??ioai N? a?aeiiaeee ciai?oi?i ?ic?yaeii 200 Aeae. O 12,5% aeiaaee?a EA oneeaaeieeany OO. Ioaea, ANEA a oae?e aeaeo?iaei?e eiio?ao?aoe?? ia iaea ia?aaaa iaae ciai?oiueith. Iai?ioe, ANEA a?oaciei ?ic?yaeii, ui iaiineany i?ae aeaiia eioooeiaeie aeaeo?iaeaie (o a?ioeaaiio neion? oa i?aaiio ia?aaena?ae?), aeyaeeany aenieiaoaeoeaiith ye a?aeiinii ni?iaieiaaii? no?eei? IA o iaoe??io?a, ye? i?ioiaeeee i?ioeaaeo?o EA c i?eaiaeo ?ioeo IOO (33 c 34), oae ? a?aeiinii IA, ?acenoaioii? aei ciai?oiuei? EA (13 c 14). Ii??a aeao?a?eeyoe?? neeaa a?aeiia?aeii 6,2(5,8 oa 8,4(7,1 Aeae (p<0,02). Inoaiith a?oio aoei neeaaeaii iaoe??ioaie, a yeeo ?acenoaioi?noue aei EA aoea iaoiiaeaiith ia cia/iith aeeeaoaoe??th e?aiai ia?aaena?aey (4,6(1,1 ni), a i?aeaeuaiei aiane?aeie iaee??iiy /e aio?caie o?ainoi?aeaeueiei ?iiaaeainii (?iaeaen iane o?ea 32(13 ea\i i?ioe 28,4(7,2 ea\i a ia?o?e i?aea?oi?, p<0,02; na?oeaaee ?iiaaeain 58,7(6,7 Ii i?ioe 58,2(5,6 Ii). Iaoe??ioai, ye? ia oa?eoee aei iienaieo aeine?aeaeaiue aeaeo?e/ii? EA, aeey a?aeiiaeaiiy N? ?ooeiii i?ecia/aany ai?iaea?ii. 77 iaoe??io?a c o?eaae?noth a?eoi?? 56(12,6 ae?a aoee ?aiaeii?ciaai? aei aeaio ?aaeei?a iaaaioaaeaiiy: 600 ia\aeia. i?ioyaii 3 oeaei?a, oa 800 ia\aeia. – i?ioyaii /ioe?ueio. Ca aeo?aeieie oa?aeoa?enoeeaie a?oie ia a?ae??ciyeeny. Oi/ iai?ee?ioe? iaaaioaaeaiiy *NN a a?oi?, yea io?eiaea 22,4 a, aoea aeinoia??ii ieae/ith (54(11 i?ioe 66(14, p<0,01), oea ia i?ecaaei aei cieaeaiiy ia?aiineiino?, a ii??aiyii? c a?oiith iaoe??io?a, ye? io?eiaee 12,6 a (94% i?ioe 93%, IAe). I?e oeueiio aoaeoeai?noue oa?ai?? a?eueoith aeicith aoea aeuith (73% i?ioe 55% p<0,02) ? N? a?aeiiaeyany ?ai?oa (19(7 i?ioe 23(5 ae?a, p<0,05). 63 iaoe??ioai ai?iaea?ii aoa i?ecia/aiee c iaoith o?eaaei? i?io?eaeoeee. I?ney iaaaioaaeaiiy 22,4 a i?ioyaii 4 oeaei?a aeico cieaeoaaee aei 400 ia\aeiao ia 2 i?n., a caiaeii oeo?oaaee aei i?i?iaeueii? aoaeoeaii?. Oiea?aioieie aei iaaaioaaeoth/i? aeice aoee 57 in?a. A 4 caa?aaeeny iaiaaee IA. 51 iaoe??io i?eeiaa i?aia?ao i?ioyaii 3,5(1,2 ?ie?a. Na?aaeiy i?aeo?eioth/a aeica neeaea 343(67 ia\aeia. 90% iaoe??io?a i?eeiaee 300 /e 400 ia\aeia. ?icaeoie ?acenoaioiino? aei i?aia?aoo a aeic? 400 ia\aeia. caiioiaaii a 5 iaoe??io?a. O?i? c ieo iaee AeEII. A oe?eiio, aoaeoeai?noue oa?ai?? aoea noaa?eueii aenieith i?ioyaii anueiai ia??iaeo niinoa?aaeaiiy, aea oiea?aioi?noue aei ia? i?ia?aneaii cieaeoaaeany oae, ui iai?ee?ioe? ia??iaeo niinoa?aaeaiiy oa?ai?th i?iaeiaaeoaaee o?eueee 18 (35,3%). Iniiaiith i?e/eiith a?aei?ie i?aia?aoo aoea neiioiiaoe/ia neioniaa a?aaeeea?ae?y. Iiaeeeaith aeueoa?iaoeaith iino?ei?e oa?ai?? ? oa?ai?y, i???ioiaaia ia ia?aaea?nieee /e neooaoe??, oeiia? aeey aeieeiaiiy IA. Oanooth/e oeth a?iioaco, i?iaaaeaii ?ao?iniaeoeaiee aiae?c i?io?eaeoe/ii? aoaeoeaiino? i?iiaoaiiio oa aeeciie?aieaeo – AAI ? eeano c ??ciini?yiiaaiith aeoeai?noth a?aeiinii AIN a a?oi? c 72 iaoe??io?a c iiai?ioiith IA. Aiia aoea iaeiaeiaith ? a caaaeuei?e, ? a ci?oai?e a?oiao iaoe??io?a, ye? iaee ye aaaoni?, oae ? aae?aia?a?/i? iaiaaee /e\oa oae?, ca’ycie yeeo c aaoiiiiiei aeenaaeainii ia aoa yaiei. I?ioyaii 8,5(4,6 i?n. caaaeueia aoaeoeai?noue i?aia?ao?a neeaea 65,8% oa 64,7% (IAe) aeey ia?oi? ? 64,0% oa 73,9% (IAe) aeey ae?oai? a?oi. AAO aeeciie?aieaeii aoea aoaeoeaiith o 9 c 10 iaoe??io?a c aaaoniith IA oa a aeiaeiiai c aae?aia?a?/iith (p<0,02). I?iiaoaiii aoa aoaeoeaiei a 3 c 5 (60,0%) iaoe??io?a c aae?aia?a?/iith IA ? a 3 c 10 (30,0%) iaoe??io?a c aaaoniith. Io?eiai? ?acoeueoaoe iaa?oiooaaee i?iaaaeaiiy ?aiaeii?ciaaiiai aeine?aeaeaiiy aeeciie?aieaeo oa i?iiaoaiiio o 55 iaoe??io?a c i?/iith aaaoniith IA (58(13 ?ie?a, 71% /ieia?e?a, ?ON – 11%, AA – 45%). I?ioyaii 6,4(5,6 i?n. aiie io?eioaaee aeeciie?aieae (29) ? i?iiaoaiii (26) ia i?/ a?aeiia?aeii ii 100-200 oa 150-300 ia. Ca ee?i?/ieie oa?aeoa?enoeeaie a?oie i?/ei ia a?ae??ciyeeny. Ee?i?/ia iie?ioaiiy a?aecia/aee an?, e??i iaeiiai (95,6%) iaoe??ioe aeeciie?aieaeiai? a?oie oa o?eueee 7 (26,9%) iaoe??io?a c oeo, ye? i?eeiaee i?iiaoaiii (p<0,001). O?e (11,5%) iaoe??ioa inoaiiuei? a?oie a?aecia/aee ii/ano?oaiiy iaiaae?a ia oii? e?eoaaiiy. Iai?ee?ioe? niinoa?aaeaiiy aeeciie?aieae i?iaeiaaeoaaee i?eeiaoe 24 (82,8%) iaoe??ioe ? o?eueee 9 (34,6%) i?eeiaee i?iiaoaiii (p<0,01). A?eueieie a?ae neiioii?a a?eoi?? aoee a?aeiia?aeii 22 (75,9%) ? 4 (15,4%) iaoe??ioe (p<0,001). An? iaoe??ioe aeea?. Aeeiai?ee AoiEA ia aeyaeaii. I?ia?eoi?e ia ca?a?no?iaaii i? a eiai. Iia?/i? yaeua oa?ai?? iaaoee ?icaeoeo a 1 iaoe??ioa aeeciie?aieaeiai? ? 1 iaoe??ioa i?iiaoaiiiiai? a?oi. 57 iaoe??io?a (60(12 ?., 54% /ieia?e?a) c aaaoniith /e ia?aaaaeii aaaoniith IA, i?eeiaee aeeciie?aieae i?ioyaii 19,4(9,6 i?n. Oei, ooi iaa aeeeth/ii i?/i? ia?ienecie, aeeciie?aieae (150-300 ia) i?ecia/aee eeoa aaciina?aaeiuei ia?aae niii. Oei, ooi iaa e??i oiai ia?ienecie, iia’ycai? c ia?a?aeaiiyi, i?ecia/aany ?aaeei ?icae??aiaiiai oa?/oaaiiy. O oeo aeiaaeeao, eiee oeae ?aaeei i?eioneaeiny ii?ooeoe (nayoeia? o?aiace, iniaeeai oethaeai? no?aae, oiui), i?iiiioaaee i?eeiaoe i?aia?ao ca 1 aiae. aei i/aaeaeieo ia??o?a o oa?/oaaii?. *a?ac 2-4 i?nyoe? iino?eiiai i?eeiio i?aia?aoo iaoe??io?a, ye? a?ae/oaaee ia?aaea?nieee, /e iia’ycoaaee iiyao IA eeoa c iaaieie oiiaaie (o?ce/ia /e ineoiaiioe?eia iaaaioaaeaiiy iaia?aaeiaei?, ci?ie iiaiaee, oiui) ?ioi?ioaaee i?i iiaeeea?noue i?eeiaoe i?aia?ao ia eiaeiiai aeiy, a eeoa ca oeo ianoaaei, eiee, ia ?o aeoieo, aeieeiaiiy IA ? iiaeeeaei. Aea ??oaiiy i?i ci?io ?aaeeio oa?ai?? iaoe??ioe i?eeiaee naiino?eii. Oa?ai?y aeyaeeany aoaeoeaiith o 41 (71,9%) iaoe??ioa. 18 (31,6%) aoee a?eueieie a?ae neiioiiaoe/ii? IA. Na?aae oeo, a eiai AAO a iienai?e noai? ia iaea oni?oo a?eueo?noue neeaee iaoe??ioe, ye? ia ii/aoeo iaee ia?aaaaeii (aea ia o?eueee!) aaaoni? ia?ienecie. Aeania, oa?ai?y i?/ieo ia?ieneci?a aoea aoaeoeaiith ? o 10 (71,4%) c ieo, aea ae caa??aaeeny aeaii? ia?ienecie, ye? caeeoaeeny ia?ica’ycaiith ee?i?/iith i?iaeaiith. Aei oiai ae 6 c oeeo 10 eiinoaooaaee ii/ano?oaiiy aeaiieo iaiaae?a. Ni?iaa i?ecia/eoe a?aioe? aaoa-aeieaoi?e /e/oa i?iiaoaiii, a ia?aae niii aeeciie?aieae ia iaea oni?oo o 7 c 10. ?c 43 iaoe??io?a c aeeeth/ii aaaoniith IA 22 (19 eeoa c i?/ieie iaiaaeaie oa 3 ?c i?/ieie oa iia’ycaieie c i?eeiiii ?ae?) i?ioyaii anueiai ia??iaeo aeine?aeaeaiiy i?eeiaee i?aia?ao ?aaoey?ii. 21 - ia?aaaaeii a ?ac? iiyae ia?aaea?niee?a oa//e eo?naie o iaai? ia??iaee. A?n?iiaaeoeyoue (41,9%) iaoe??io?a aoee a?euei? a?ae neiioiiaoe/ii? a?eoi?? i?ioyaii anueiai ia??iaeo niinoa?aaeaiiy: 17 (48,6%) c oeo, ye? iaee aeeeth/ii i?/i? i?enooie (p<0,02), oa 1 (12,5%) c oeo, a eiai aoee e ?io? aaaoni? ia?ienecie. 15 (83,3%) c ieo i?eeiaee i?aia?ao iino?eii, 3 (14,3%) - eeoa a ?ac? iiyae ia?aaea?niee?a. A?aeiia?aeii, a?eueieie a?ae neiioiiaoe/ii? IA aoee 65,2% iaoe??io?a, ye? io?eioaaee i?aia?ao uiaa/i?a, ? eeoa 14,3% c oeo, ye? i?eeiaee eiai ca ia?aaea?nieeaie (p<0,001). Na?aae iaoe??io?a c aeeeth/ii i?/iith IA oe? iieacieee aoee aeueie: a?eueieie a?ae neiioiiaoe/ii? IA aoee 17 c 19 (89,5%), ui io?eioaaee iino?eio oa?ai?th, ? 1 c 3 (33,3%) c oeo, ye? i?eeiaee aeeciie?aieae ca ia?aaea?nieeaie (p<0,001). A oe?eiio, iai?ee?ioe? ia??iaeo niinoa?aaeaiiy 34 c 35 (97,1%) iaoe??io?a c aeeeth/ii i?/iith IA ? 3 (37,5%) c 8, a eiai iaiaaee IA aoee iia’ycai? oaeiae c ?ioeie ianoaaeiaie, ?icoe?ithaaee ?acoeueoao oa?ai?? ye iiceoeaiee oa i?iaeiaaeoaaee i?eeiaoe aeeciie?aieae. Eiai na?aaeiueiaeiaiaa aeica a a?oi?, yea io?eioaaea iino?eio oa?ai?th, neeaea anueiai 133(43 ia. Iia?/i? aoaeoe i?aia?aoo a?aei?/aii o 5 iaoe??io?a (11,6%). Eeoa aeai? c oeeo iaoe??io?a cian?i i?eieieee oa?ai?th i?aia?aoii. ?aooa iaaeae? i?eeiaea eiai ca ia?aaea?nieeaie. O./., oa?ai?y aeeciie?aieaeii aeyaeeany aeeeth/ii aoaeoeaiith ? aeineoue aacia/iith a a?oi? iaoe??io?a c i?/iith IA. Inoaiiy, i?ioa, yaey? niaith eeoa iaaaeeeo /anoeo aeiaaee?a IA. Uiaei a?eueoino? iaoe??io?a oaea “i’yea” oa?ai?y iaiiaeeeaa. Aea ae, a?aoiaoth/e aenieo /anoioo iia?/ieo aoaeo?a iino?eii? AAO i?aia?aoaie ? oa ??? eean?a, iaae?eia noaa?e?caoe?y i?iea?aea ia?aaena?aeue a aaaaoueio aeiaaeeao ? ia?aaeueiith caaea/ath. Oiae? iaoith inoaiiuei? noa? ia i?io?eaeoeea IA, a eeoa eiio?ieue *NN. Iacaaaeath/e ia ia?aaaae inoaiiuei? no?aoaa?? o aacia/iino?, iaia?aiinei?noue ? iaaeinoaoiy aoaeoeai?noue caeeoathoueny ?? na?eicieie iaiaaeaiiyie. EA AA c’?aeiaiiy iinoa? iaoa?iaeieia?/iith aeueoa?iaoeaith eiiaaioe?iiaeuei?e oa?ai??. 78 iaoe??ioai (62(8 ?., 66% /ieia?e?a, i?aai?/ia iaoieia?y na?oey – 33%, AA – 63%, OA-34(16%) c iino?eiith IA ?acenoaioiith aei iaaeeeaiaioicii? oa?ai?? cai?iiiiiaaia iaoa?iaeieia?/ia e?eoaaiiy. 38 i?ieoee i?ioeaaeo?o. Oni?oo aeinyaiaii o 36. ?iieaiooaaee ia?aaaaeii VVI-iaeniaea?e. 40 a?aeiiaeeeny ? ?acii c aeaiia, a eiai aeano?oeoe?? AA c’?aeiaiiy ia aeinyaiooi, neeaee eiio?ieueio a?oio. Ca ee?i?/ieie iieacieeaie a?oie ia a?ae??ciyeeny. Aaea /a?ac 1 oeaeaeaiue i?ney EA a?aei?/aii ca?eueoaiiy OA (60(15% i?ioe 32(15%, p<0,001) oa (S (33(10%, i?ioe 21(9%, p<0,001). *a?ac 3(1 ?ie?a niinoa?aaeaiiy aeea? 30 (83,3%) iaoe??io?a c oeo, eiio i?iaaaeaii EA ? 25 (62,5%) c eiio?ieueii? (p<0,02). I?ia?anoth/a NI ia?aaeoaaea nia?o? a 2 (16,7%) iaoe??io?a ia?oi? a?oie oa 8 (53,3%) iaoe??io?a ae?oai? (p<0,002). ?inoeueoe ia?aianee a?aeiia?aeii 2 (5,6%) ? 3 (7,5%) iaoe??ioe (IAe). EA AA c’?aeiaiiy iaea ia?aaaae iaae eiiaaioe?eiith oa?ai??th ? uiaei e?eueeino? ui??/ieo aini?oae?caoe?e (0,7(0,5 i?ioe 3,6(2,7, ?<0,001), e?eueeino? e?e, ui i?eeiaeeny (1,7(1,6 i?ioe 4,6(2,3 ?<0,001), iieaciee?a o?ce/ii? aeoeaiino? oa yeino? aeeooy, iaoiiaeaieo noaiii caei?ia’y. Aeaeo?e/ia noeioeyoe?y aeey i?eieiaiiy o??iio?iiy ia?aaena?aeue. O??iio?iiy ia?aaena?aeue ? a?eoi??th a aaaaoueio aniaeoao aeecueeith aei IA. Aea iniaeeaino? eiai aeaeo?io?c?ieia?/ieo iaoai?ci?a iaoiiaeththoue iiaeeea?noue aeei?enoaiiy a eiai e?eoaaii? aeayeeo iaoa?iaeieia?/ieo iaoiaeee, ye? ia iiaeooue aooe canoiniaai? o iaoe??io?a c IA. Ii??aiyiiy ?acoeueoao?a /a?acno?aaio?aeii? (530 i?ioeaaeo?) ? aiaeiea?ae?aeueii? (42) noeioeyoe?e ia aeyaeei ia?aaaa inoaiiuei? (85,74% i?ioe 81,1%, IAe). Eiiaa?n?y IA o OI anioe?thaaeany ?c cieaeaiiyi na?aaeiuei? *NN c 137(21 aei 114(36 oae/oa ? neiioiiaoe/iei iie?ioaiiyi o a?eueoino? iaoe??io?a. Caaaeueia aoaeoeai?noue *NAN ia caeaaeaea a?ae oeio OI (88,7% aeey oeiiaiai oa 86,7% aeey aoeiiaiai, IAe). Aea a a?oi? c oeiiaei OI N? /ano?oa aoa ?acoeueoaoii i?ioeaaeo?e (59,2% oa 35,2% a?aeiia?aeii, p<0,0001). Iiia?aaeiy aeea?oae?caoe?y iaaaoeaii aieeaaea ia ?acoeueoaoe *NAN (74% i?ioe 88% a a?oi?, aea oa?ai?y ia i?iaiaeeeany, p<0,05). Iai?ioe *NAN ia oii? AAI ? /e ??? eean?a aoea aoaeoeai?oith (95% i?ioe 88%, p<0,05 ). AAI ?? oa ?V eean?a ia aieeaaee ia ?? aoaeoeai?noue (86,2%). A?eueoa o?eaae?noue OI anioe?thaaeany c iaioith aoaeoeai?noth i?ioeaaeo?e, aea aeinoia??ia cieaeaiiy aoaeoeaiino? caiioiaaii eeoa i?ney 6-ai i?nyoey ia?nenooaaiiy a?eoi??. Naieaeanyoe naie c 88-ie iaoe??io?a, ye? caa?aaee OI aoa i?ecia/aiee ai?iaea?ii (800 ia\aeia i?ioyaii 4 oeaei?a). N? a?aeiiaeany o 38 (49,3%). ?aoo? i?ney cae?i/aiiy ia??iaeo iaeiie/aiiy /e iae?aco ae i?ney a?aei?ie i?aia?aoo /a?ac ?icaeoie iia?/ieo aoaeo?a i?iaaaeaii iiaoi?io *NAN. N? aoa a?aeiiaeaiee o 17 (43,6%) c oeeo 39, ua o 7 (18%) OI ia?aaaaeaii a IA. A oe?eiio, *NAN aeyaeeany aenieiaoaeoeaiei iaoiaeii i?eieiaiiy iiai?ioiiai OI, yeee oyaey?oueny aea?aeiith aeueoa?iaoeaith aeaeo?e/i?e EA. Eaoaoa?ia aaeyoe?y. 112 iaoe??io?a (69% /ieia?e?a, 59(16 ?.) c OI i?ieoee EA ia?aoeeea i?ae o?eeoni?aeaeueiith nooeeith oa ieaeiueith ii?iaeiueith aaiith. A 55 (45,1%) aeiaaeeao EA i?iaiaeeeany ia oii? niiioaiiiai /e ni?iaieiaaiiai OI, a 67 (54,9%) ?ioeo - ia oii? noeioeyoe?? ae?eyiee ae?ea a?ioeaaiai neiono c /anoioith 100 ?ii/oa. Cae/aeii, o iaoe??io?a, ye? ii/aoeiai iaee OI, inoaii? aoei iiaeeeaei eeoa i?ney a?aeiiaeaiiy N? aeaeo?e/iith noeioeyoe??th /e aeaeo?e/iith EA. Ca ee?i?/ieie oa?aeoa?enoeeaie a?oie ia a?ae??ciyeeny. Aaciina?aaeiueiai aoaeoo aaeaeiny aeinyaoe o 98 (87,5%) iaoe??io?a. Aeey oeueiai iio?aaoaaeiny noai?eoe 4,9(2,4 e?i?e ? cae?enieoe 41,4(40,5 (9-137) aie?eaoe?e ?* aia?a??. E?i?y “e?eueoea o?eeoni?aeaeueii? nooeee - ae?ei a?ioeaaiai neiono” aeyaeeany aoaeoeaiith o 3 (3,1%) aeiaaeeao, e?i?y “ae?ei a?ioeaaiai neiono - ae?ei ieaeiuei? ii?iaeiuei? aaie” - a 9 (9,2%) ? e?i?y “o?eeoni?aeaeueia nooeea - ae?ei ieaeiuei? ii?iaeiuei? aaie” - a 86 (87,7%). A?aeiiaeaiiy N? ia oii? aie?eaoe?? niinoa??aaee o 52 (96,3%) iaoe??io?a. Oi/ a oe?eiio i?ioeaaeo?a aoea ?icoe?iaia ye oni?oia eeoa i?ney 2,4(3,1 ?a?iaeoeoe?e, o 2 aeiaaeeao ?iaeoeoe?y OI noaea iaiiaeeeaith aaea i?ney ia?oi? aie?eaoe??. A a?oi?, aea e?eoa???i oni?oo aoea aa?eo?eaoe?y ?noion-aeieo, a ?ac? iayaiino? inoaiiueiai, ee?i?/ia OI ia aoei ni?iaieiaaii aeiaeiiai ?aco. Ii??aiyiiy oni?oieo oa aaconi?oieo EA OI cana?ae/eei, ui iaoe??ioe, a eiai oni?oo aeinyaoe ia aaeaeiny, iaee a?eueoo ieiuo i?aaiai ia?aaena?aey (22,4(4,1 i?ioe 20,2(4,0 ni2, p<0,02). A?eueoith a oe?e a?oi? aoea oaeiae e?euee?noue eiaaoeyoe?e (67(36 i?ioe 36(21, p<0,001). A?eueoa ieiua i?aaiai ia?aaena?aey a?aeaeaa?, a??ia?aeii, a?eueoee ?ici?? ia?aoeeea. Oey aiaoii?/ia iniaeea?noue, cae/aeii, oo?oaeith? noai?aiiy aacia?a?aieo e?i?e iioeiaeaeaiiy /a?ac iueiai. I?ioyaii 2,3(2,2 (0,5 - 5) ?ie?a niinoa?aaeaiiy ?aoeeaeeae ee?i?/iiai OI iaee 11 (11,2%) iaoe??io?a c oeo, a eiai i?ioeaaeo?a aoea ?icoe?iaia ye oni?oia. OI ?aoeeaeoaaei o 3 (6,6,%) c 45 iaoe??io?a c a?oie, aea e?eoa???i aoaeoeaiino? aoea iiyaa iciae ?noion-aeieo, ? o 8 (18,6%) c 43 a ae?oa?e a?oi? (p<0,01). N?i c 11 iaoe??io?a, a eiai OI ?aoeeaeoaaei ia?aeiii, iaee iino?eia OI, ?acenoaioia aei AAO oa *NAN. OI-?aoeeaeea aoei /ooeeaei aei oeeo ai?aa o 6 c ieo. Iaoe??ioe, ye? ia?aianee ?aoeeaeeae, iaee a?eueoo ieiuo i?aaiai ia?aaena?aey (23(5 i?ioe 17(6 ni2, p<0,001). A oe?e a?oi? /ano?oa niinoa??aaany oaiiiai a?aeiiaeaiiy i?iaaaeaiiy /a?ac ia?aoeeie /a?ac 1-15 oaeeei i?ney iiyae iciae ?noion-aeieo (73% i?ioe 26%, p<0,0001), ui iio?aaoaaei aeiaeaoeiaeo eiaaoeyoe?e. Aeieoiaioiaaio ee?i?/io IA aei EA OI iaee 10 (9,0%) in?a. Ua o 15 (13,4%) iaoe??io?a iayai?noue IA iiaeeeai aoei i?eionoeoe ia i?aenoaa? aiaiiaco. Iaoe??ioe aoee ?ioi?iiaai? i?i iiaeeea?noue caa?aaeaiiy IA i?ney EA OI. I?ae /an aacaeueiiai /e eiio?ieueiiai (iae?aco ae i?ney EA) aeine?aeaeaiue IA o?eaae?noth a?eueoa 1 oa. aoea ni?iaieiaaia o 30 (26,8%) iaoe??io?a. 20 c ieo iaee a?aeiio IA. Ioaea, caeaoi?noue ia?aaena?aeue aei o?eaaei? o?a?eeyoe?? aoea aeyaeaia o 35 ?c 112 (31,3%) iaoe??io?a. Iaoe??ioe c OI ? IA aoee noa?oeie ca oeo, ye? iaee eeoa OI (64(21 oa 56(19 ?., p<0,02) oa o?eaae?oee a?eoi?/iee aiaiiac (3(3 i?ioe 2(2 ?., p<0,002). I?ae /an niinoa?aaeaiiy iiai?ioia IA c’yaeeany o 39 (39,8%). 11 (28,2%) c ieo ia iaee ?? aei EA. Iino?eia IA iaaoea ?icaeoeo o 2. Eoioeyoeaia a??ia?aei?noue aeaeeaaiiy aac IA aoea, 73% /a?ac ??e, 60% /a?ac 2 ?iee. Oa 50% /a?ac 3 ?iee. Oi?aa??aioiee aiae?c aeyaea, ui iaoe??ioe c IA a iinoaaeyoe?eiiio ia??iae? aoee noa?oeie ca a?eii (63(19 i?ioe 55(18 ?., p<0,05), /ano?oa no?aaeaeaee ia AA (52% i?ioe 41%, p<0,05), iaee o?eaae?oee a?eoi?/iee aiaiiac (3(3 i?ioe 1,7(2 ?., p<0,05), iaioo OA (45(21 i?ioe 58(24%, p<0,02) oa a?eueoee ?ici?? e?aiai ia?aaena?aey (4,7(1,3 i?ioe 4,4(1,3 ni, p<0,05). A?eueo /anoith ciao?aeeith a oe?e a?oi? aoea ee?i?/ia aeiaaeyoe?eia IA (71% i?ioe 4%, p<0,001) oa IA ni?iaieiaaia i?ae /an ao?o/aiiy /e/oa eiio?ieueiiai aeine?aeaeaiiy (46% i?ioe 15%, p<0,001). Ioeueo?aa??aioiee ?aa?aneaiee aiae?c Cox ?aeaioeo?eoaaa ye iacaeaaeiee oaeoi? eeoa iayai?noue ee?i?/ii? IA aei EA (a?aeiiniee ?ecee 4,1, ?ioa?aae 95% aeinoia??iino? 1,6 - 8,1, p<0,001). O 16% iaoe??io?a iaaoea ?icaeoeo iiaa IA. Oey i?aea?oia ??cieeany a?ae oeo, ui aoee a?euei? a?ae IA, eeoa o?eaae?noth iiia?aaeiueiai ai?ciaeo OI (18(7 i?ioe 7(6 i?n., p<0,02), yea a 89% aeiaaee?a niinoa??aaeany iiiaae ??e. Eeoa 4 iaoe??ioe iicaaaeeeny IA i?ney EA OI. 88% oai?eo c IA a ia??iae? niinoa?aaeaiiy iio?aaoaaee AAO. Aoaeoeaii? noi?an?? IA i?aia?aoaie, ui aei EA aoee iaaoaeoeaieie aaeaeiny aeinyaoe a 15 c 22 (68%) iaoe??io?a c aeiaaeyoe?eiith IA. Ua 5 (27%) in?a oe??? a?oie a?aecia/aee neiioiiaoe/ia iie?ioaiiy, i?e oiio ui aeice AAI, ye? i?ecia/aeeny aeey eiio?ieth /anoioe ?eoio a IA, aoee ieae/eie, ca oae? aei EA. O./., oi/ ia?aaaae EA o iaoe??io?a c aeiaaeyoe?eiith IA aoee iaioeie, i?ae o oeo, ui ?? ia iaee, ?noion-aaeyoe?y caaaeaea iiceoeaiiai aieeao ia ee?i?/io neooaoe?th ? a oe?e i?aea?oi?. A i?iniaeoeaiiio aeine?aeaeaii? ii??aiyee ?acoeueoaoe EA oa EA OI. Iaoa??ae neeaee 105 iaoe??io?a o a?oe? 57,8(19,5 ?ie?a, eiio aeey e?eoaaiiy OI aoei cai?iiiiiaaii EA. EA i?ieoee 66 iaoe??io?a. Aiie neeaee a?oio “EA”. A?oio “EA” neeaee 49 iaoe??io?a, ui a?aeiiaeeeny a?ae EA. A ieo e?eoaaiiy aoei ni?yiiaaii eeoa ia a?aeiiaeaiiy oa i?aeo?eiaiiy N?. Aeo?aeia /anoioa iiai?io?a OI aoea a?eueoith ca 1 ?ac ia 6 i?nyoe?a a?aeiia?aeii o 64% oa 55% iaoe??io?a oeeo a?oi (p<0,05). Ca ?ioeie ee?i?/ieie oa?aeoa?enoeeaie ? iaaeeei-nioe?aeueieie iieacieeaie aiie ia a?ae??ciyeeny. I?ioyaii 24(11 i?n. Iiai?ioe a?eoi?? (OI /e/oa IA) iaee 59 (52,7%) iaoe??io?a a?oie EA oa 86 (88,7%) iaoe??io?a a?oie EA (p<0,02). Iaaeeei-nioe?aeuei? iieacieee caciaee iiceoeaii? aeeiai?ee a a?oi? EA ? ia ci?ieeeny a a?oi? EA (?en. 1). Ni?iae EA IO aoei cae?eniaii a 15 (6 /ieia?e?a) iaoe??io?a o a?oe? 10-63 ?iee. 2 ia?aianee iia?aoe?? c i?eaiaeo na?oeaaeo aaae, 1 iaa ?ON, o ?aooe i?aai?/ii? iaoieia?? na?oey ia aeyaeaii. 2 iaee e?aiia?aaena?aeio oao?ea?ae?th, 9 - i?aaiia?aaena?aeio. Ua o 2 a noai?aii? e?eueoey reentry a?aee o/anoue iaeaeaa ia?aaena?aey oa a 2 aeoii?/iee ina?aaeie eieae?coaaany o ia?aoeioe?. Iiceoeaiiai aoaeoo aaeaeiny aeinyaoe o 11 iaoe??io?a. Aeey EA e?aiia?aaena?aeii? oao?ea?ae?? canoiniaoaaany o?ainnaioaeueiee aeinooi (1 - o?ainnaioaeueia ioieoe?y, 1 - /a?ac a?aee?eoa iaaeueia a?eii). O?e/? i?iaiaeeeany iiaeeo?eaoe?y neioniaiai aocea a iaoe??ioie c iino?eiith iaia?ieneciaeueiith oao?ea?ae?th. Aea?/? aaeaeiny aeinyaoe oni?oo. O o?ao?e noai?aii AA aeieaaeo oa ?iieaioiaaii AEN. Na?aaeiy o?eaae?noue oethi?ineii?? oa na?aaeiy e?euee?noue eiaaoeyoe?e neeaee a?aeiia?aeii 47(18 oa. oa 39(22. Na?eicieo oneeaaeiaiue ia aoei. I?ioyaii oeaeiy i?ney ao?o/aiiy IO ?aoeeaeoaaea a 2 iaoe??io?a. Iaaeae?, i?ioyaii 9(11 i?n. niinoa?aaeaiiy ?aoeeaeea?a ia aoei. 129 iaoe??io?a (52(17 ?., 43% /ieia?e?a) i?ieoee eaoaoa?io iiaeeo?eaoe?th AA i?iaaaeaiiy c i?eaiaeo AAAO. Aoeiiao AAAO iaee 14 (10,8%). O 31 (24%) iaoe??ioa ii?yae c AAAO i?iaieoaaeany IA. Aeai? i?i iayai?noue noiooiuei? IA aoee aeyaeai? a?aeiinii 22 (17,5%) iaoe??io?a. *aoaa?i aoee aiaaiai?, ui IA ii/eia?oueny caaaeaee i?ney ai?ciaeo ?aaoey?ii? oao?ea?ae??. Aeey iiaeeo?eaoe?? iia?eueiiai AA i?iaaaeaiiy aeei?enoiaoaaeeny oae? iaoiaeeee: 1. I?ney i?iaieaoe?? ee?i?/ii? oao?ea?ae?? iine?aeiaii i?iaiaeeee oanooth/? aie?eaoe?? iiia?aaeo oa o?ioe aeua ae?ea a?ioeaaiai neiono. I?ney ia?a?eaaiiy oao?ea?ae?? aoaeoeaiith oanooth/ith aie?eaoe??th inoaiith i?iaeiaaeoaaee aei iiaii?. sseui aoaeoo ia aeinyaaee, na??th aie?eaoe?e i?iaiaeeee oaeiae iicaaeo oa ieae/a ae?ea. 2. I?ae /an neioniaiai ?eoio i?iaiaeeee ea?ooaaiiy ae?eyiee iaaeiei ae?ea a?ioeaaiai neiona. Iaoith iiooeo aoea ciia, aea ?a?no?oaaeany aeaeo?ia?aia c i?i?iaeueiei ia?aaena?aeiei coaoeai A, cia/iei oeoii/eiaei coaoeai V oa aac iioaioe?aeo io/ea A?na. Aoaeoeaiith aaaaeaee aie?eaoe?th, i?ae /an yei? c’yaeyeeny eiiieaene /e ?eoie AA c’?aeiaiiy. I?ney oaei? aie?eaoe?? i?iaiaeeee ni?iae ?a?iaeoeoe?? oao?ea?ae??. sseui iiaeeea?noue inoaiiuei? caa??aaeany, aie?eaoe?? i?iaeiaaeoaaee. 3. I?iaiaeeee noeioeyoe?eia ea?ooaaiiy AA ciie a ?aaeei? i?ia?aiiaaii? noeioeyoe?? aa?oiuei? /anoeie i?aaiai ia?aaena?aey, ui caaacia/oaaa i?iaaaeaiiy iia?eueiei oeyoii aac ?iaeoeoe?? oao?ea?ae??. Iiai? aie?eaoe?? i?iaiaeeee ia ae?eyioe?, aea ?a?no?oaaee i?i?iaeueiee eieaeueiee ?ioa?aae AV. O an?o aeiaaeeao aie?eaoe?th iaaaeii i?eieiyee a ?ac? iiaeiaaeaiiy ?ioa?aaeo AI a?eueo i?ae ia 50% a?ae aeo?aeiiai; iiyae oaeaeeiai (a?eueoa 120 oae/oa.) ?eoio AA c’?aeiaiiy /e ?icaeoeo iiaii? AA /e AA aeieaaee. C?icoi?ei, yeui i?ney a?aeiiaeaiiy aeo?aeieo ia?aiao??a ciia i?iaieoaaeany AAAO, aie?eaoe?? i?iaeiaaeoaaee. A ?ac? iaiiaeeeaino? aeinyaoe aoaeoo a oeueiio ?aa?ii?, aeano?oeoe?eiee aeaeo?iae iinooiiai ia?anoaaee aeua oa aia?aae - a iai?yieo io/ea A?na. I???ioe?aie aoee aeaeo?iaeia ia?a, ui ?a?no?oaaea AA io/ea A?na oa eaoaoa? o a?ioeaaiio neion?. Ae?ei inoaiiueiai aecia/aee ca ?aioaai-aiaoii?/ieie oa aeaeo?io?c?ieia?/ieie i???ioe?aie (ca ni?aa?aeiioaiiyi aiie?ooae niaee?a ia?aaena?aeue oa oeoii/e?a 1:1). I?ioeaaeo?aeueiiai oni?oo aeinyaiooi o an?o iaoe??io?a. A ?acoeueoao? iiaeeo?eaoe?? AA i?iaaaeaiiy io?eiai? oae? aoaeoe: ia?a?eaaiiy oaeaeeiai aoceiaiai i?iaaaeaiiy a aioaa?aaeiiio /e a iaio iai?yieao- 16 (12,4%), ia?a?eaaiiy ?ao?ia?aaeiiai oaeaeeiai i?iaaaeaiiy- 9 (7,6%), ia?a?eaaiiy iia?eueiiai aoceiaiai oeyoo - 22 (17,1%), iiaeeo?eaoe?y iia?eueiiai aoceiaiai oeyoo (ae?i?iaoe?y oao?ea?ae?? ?c caa?aaeaiiyi iiaea?eiiai AA i?iaaaeaiiy) - 82 (68,9%). Aeaeo?io?c?ieia?/i? oa?aeoa?enoeee, ye? iaee iaoe??ioe aei oa i?ney iiaeeo?eaoe?? AA i?iaaaeaiiy iaaaaeai? o oaaeeoe? 4. Ii??aiyeueiee aiae?c iaoiaeee iiaeeo?eaoe?? AA i?iaaaeaiiy, iieacaa, ui an? aiie iaeiaeiai aoaeoeai? ? aeicaieythoue aeinyaoe oni?oo a 100% aeiaaee?a. I?ioa, iaianaiiy aie?eaoe?e i?ae /an oao?ea?ae?? anioe?thaaeiny c a?eueoeie e?euee?noth aie?eaoe?e, o?eaae?noth i?ioeaaeo?e oa /anii oethi?ineii??, i?ae i?ae /an N?. Oa?i?iaoe?y oao?ea?ae?? i?ae /an aie?eaoe?? aeyaeeany niaoeeo?/iith (100%), aea ia /ooeeaith (36%) iciaeith. Ca oeie ae iieacieeaie ia?aaei?e i?aeo?ae i?ia?aaaa caaeiueiio. Aei oiai ae iiaeeo?eaoe?y AA i?iaaaeaiiy o iiceoe?? oaeaeeiai oeyoo anioe?thaaeany ?c cia/iei i?aeaeuaiiyi /anoioe ?icaeoeo ei?ioei/anii? AA aeieaaee II-III nooiaith. A?eueo?noue aie?eaoe?e a oeueiio ?aa?ii? aaea aei oei/aniaeo ii?ooaiue AA i?iaaaeaiiy. A?aoo?, iaoiaeeea iiaeeo?eaoe?? AA i?iaaaeaiiy, i???ioiaaia ia aeai? noeioeyoe?eiiai ea?ooaaiiy, aeyaeeany iaeaacia/i?oith, aea anioe?thaaeany ?c iaaiei i?aeaeuaiiyi o?eaaeino? ao?o/aiiy oa /ano oethi?ineii??. I?ioyaii ia??iaeo niinoa?aaeaiiy nea?ae ia i?enooie na?oeaaeooy i?aae’yaeyee 32 (24,6%) iaoe??io?a. Ianoaaeaiiy iieacaei, ui 12 (9,2%) c ieo iaee ?aoeeaeeae ee?i?/ii? AAAO, 10 (7,7%) – IA, 3 (2,3%) - iino?eio neioniao oao?ea?ae?th, ?io? (5,4%) - eeoa iaa?ioe/i? ?iceaaee. An? ?aoeeaeeae aeieeee i?ioyaii ia?oeo 6 i?nyoe?a i?ney ao?o/aiiy. 10 (83,3%) c ieo i?eeoeiny ia oeo iaoe??io?a, ui i?ieoee iiaeeo?eaoe?th iia?eueiiai i?iaaaeaiiy ? caa?aaee aeo?aei? Oaaeeoey 4. Aeeiai?ea aeaeo?io?c?ieia?/ieo iieaciee?a i?ae aieeaii iiaeeo?eaoe?? AA i?iaaaeaiiy Iieacieee\iaoiae iiaeeo?eaoe?? AA i?iaaaeaiiy Aeano?oeoe?y aOO /e aOO (+?OO) Aeano?oeoe?y ?IO Aeano?oeoe?y IO Iiaeeo?eaoe?y IO E?euee?noue iaoe??io?a 16 9 22 82 AI, in 74(20/171(37** 81(13/90(21 77(19/72(22 78(14/76(21 aA?I OO, in 361(72/- 363(70/376(84 344(85/312(88* 363(80/337(82* aA?I IO, in 267(75/270(73 258(63/253(61 251(64/ - 256(61/251(63 oi/ea Aaieaaaoa o AA i?iaaaeaii?,in 358(66/360(72 355(59/359(61 383(84/414(93* 355(59/359(61 ?A?I AA c’yaeiaiiy, in 239(43/262(71* 266(46/ 237(48/237(51 305(56/303(72 Iiaeeea?noue oi/ ae iaeiiai reentry 0 82 (90,1%) 0 82 (90,1%) I?ei?oee: * p<0,01; ** p<0,001 aeaeo?io?c?ieia?/i? iieacieee. An? 12 (9,3%) iaoe??io?a i?ieoee iiaoi?io EA, i?ney /iai iiaeo ?aoeeaeea?a ia aoei i? a eiai. Aeaeo?io?c?ieia?/i? ia?aiao?e AAAO- ?aoeeaeeao ia a?ae??ciyeeny a?ae ia?aeiii? AAAO. *ano?oa ?aoeeaeeae aeieeaee o ae?iie. ?o aeiey a oe?e a?oi? neeaea 83% i?ioe 54% a a?oi? aac ?aoeeaeea?a (p<0,001). O?aiceoi?ia AA aeieaaea i?ae /an eiaaoeyoe?? iaaeyaeaeany o 25% iaoe??io?a, ui ia?aianee ?aoeeaeeae ? eeoa o 4% iaoe??io?a aac ieo (p<0,001). *ano?oa iaaeyaeaeeny a oe?e a?oi? aeenioe?aoe?y ia /eneaii? aoceia? oeyoe (33% i?ioe 11%, p<0,02). Ia aoei ??cieoe? a /anoio? ?aoeeaeea?a a caeaaeiino? a?ae oiai, yeee c i?aia?ao?a aeei?enoiaoaaee aeey ia?aa??ee iaae?eiino? aoaeoo EA: 5 c 56(8,9%) aeey ao?ii?io i?ioe 6 c 63(9,5%) aeey i?oeei?aiae?io, IAe. O 8 (80%) c 10 iaoe??io?a c i?neyaaeyoe?eiith IA, ?? aoei ni?iaieiaaii i?ae /an ao?o/aiiy. 9 iaee a?aeiio ee?i?/io IA/OI aei ao?o/aiiy. An? aiie a?aei?/aee cia/ia iie?auaiiy ee?i?/ii? neooaoe??, yea a?aeaeaaeiny o cieaeaii? e?eueeino? oa o?eaaeino? a?eoi?/ieo ai?ciae?a, a a 7 (70%) aeiaaeeao - oaeiae o cieaeaii? *NN i?ae /an ia?ienecio. 4 (40%) iaoe??io?a iio?aaoaaee i?io?eaeoe/ii? AAO, oa ua 1(10%)-oa?iaeieia?/ii? EA. Aeaaiaaeoeyoue iaoe??io?a iicaaaeeeny IA i?ney EA AAAO. Aeine?aeaeaiiy iieacaei, ui EA ? aoaeoeaiei oa aacia/iei iaoiaeii ei?aeoe?? ?aoeei?ieieo AAAO. Iaoiaeeeith aeai?o oyaey?oueny i?iaaaeaiiy iiaeeo?eaoe?? iia?eueiiai i?iaaaeaiiy ia oii? neioniaiai ?eoio c aeei?enoaiiyi ?aioaai-aiaoii?/ieo oa aeaeo?io?c?ieia?/ieo i???ioe??a. Iaeaacia/i?oei aa??aioii ao?o/aiiy ? i?ea?iaeueia iaoiaeeea eieae?caoe?? iia?eueieo oeyo?a ca aeaieie noeioeyoe?eiiai ea?ooaaiiy. O iaoe??io?a c ia?aaena?aeieie oao?a?eoi?yie oa AAAO ae?i?iaoe?y inoaiiuei? ia caiia?aa? iiai?ioai ia?aaena?aeieo ii?ooaiue ?eoio, aea iieaaoo? ?o ia?aa?a. 130 iaoe??io?a (61% /ieia?e?a, 34(24 ?.) i?ieoee EA AeOI c i?eaiaeo IOOaeoi. Aoaeoeai?noue iaoiaeeee neeaea 96,2%. Aiia, aoea iaeiaeiaith iacaeaaeii a?ae oiai ye i?iaiaeeeeny eiaaoeyoe??: i?ae /an AAO, N? /e ia?aaena?aeii? noeioeyoe??. Aeano?oeoe?y AeOI i?eaaea aei ia?a?eaaiiy aaio?eeoei-ao??aeueiiai i?iaaaeaiiy o 38 (29,2%) iaoe??io?a. C oeo, ui eiai caa?aaee 59 (64,1%) iaee yai? ci?ie iine?aeiaiino? caoaeaeaiiy AA e?eueoey, yea i?ney EA noaei eiioeaio?e/iei. A 33 aeiaaeeao yaieo ci?i iine?aeiaiino? aaio?eeoei-ao??aeueii? aeoeaaoe?? ia a?aeaoeiny. Aeey ia?aa??ee iaae?eiino? aoaeoeaiino? EA a ieo aoei i?iaaaeaii oano c aioo??oiueiaaiiei aiethnii aaeaiiceio ia oii? iino?eii? oeoii/eiai? noeioeyoe??. Aaeaiicei ia?a?aaa aaio?eeoei-ao??aeueia i?iaaaeaiiy a 27 aeiaaeeao: 12 ia - 20 c 33 iaoe??io?a, 18 ia - 4 c 9 iaoe??io?a, oa 24 ia - 3 c 5 iaoe??io?a. 3 iaoe??ioai, a yeeo aaaaeaiiy i?aia?aoo aecaaei no?eeo IA, aeica ia i?aeaeuoaaeany. Iaeei a?aeiiaeany a?ae iiaoi?ii? ?i’?eoe??. A oe?eiio, /ooeea?noue oanoo neeaea 82%, a /anoioa iiieeeiaiiaaaoeaieo ?acoeueoao?a 9,1%. A ia??iae? niinoa?aaeaiiy ?aoeeaeeae i?iaaaeaiiy ii AeOI iaee 5 (3,8%) iaoe??io?a. Aeai? c ieo aoee a?eueieie a?ae a?eoi??. Nea?ae ia na?oeaaeooy caa?aaee 16 (12,4%) iaoe??io?a. C ieo 3 iaee ?aoeeaeeae, 1 - AAAO, 6 - IA. ?io? ia iaee ii?ooaiue na?oeaaiai ?eoio. ?o nea?ae aoee iaoiiaeai? iaa?ioe/ieie ?iceaaeaie. AAO aoee onoiai? iiaoi?iith i?ioeaaeo?ith. O an?o iaoe??io?a c IA aoa iiaeeeaei oa?iaeieia?/iee eiio?ieue /anoioe ?eoio. An? aiie iaee IA aei EA AeOI. A oe?eiio, iaoe??ioe, ye? caa?aaee IA i?ney EA AAO (iacaeaaeii a?ae oeio oao?ea?ae??) a?ae??ciyeeny a?ae oeo, ooi ca?eueieany a?ae iaio a?eoi?e (oaaeeoey 6). *a?ac 6 i?nyoe?a i?ney EA IOO 15 c 16 (93,8%) iaoe??io?a, a eiai caa??aaeany IA, a?aei?oeee, ui i?ioeaaeo?a caaeaea iiceoeaiiai aieeao ia ia?aa?a ?o a?eoi?? acaaae? ? 13 (81,3%) - naia IA. I?ney EA 11 iiooaaee oiia?eueiaiiy *NN i?ae /an i?enooio na?oeaaeooy, 12 - ciaioaiiy /anoioe i?enooi?a aeania ia?aaoey?iiai na?oeaaeooy. Aei EA iino?eii i?eeiaee AAI 11 c 16 (68,8%) iaoe??io?a, 7 (43,8%) c ieo - i?aia?aoe ? /e ??? eean?a. I?ney EA e?euee?noue oaeeo iaoe??io?a cieceeany a?aeiia?aeii aei 7 (43,8%) oa 2 (12,5). C iaoith c’ynoaaoe /e i?io?oothoue a?ae EA IOO iaoe??ioe oe??? a?oie aoee i?iaiae?ciaai? ?acoeueoaoe niinoa?aaeaiiy ca 39 (53(11 ?., Oaaeeoey 6. Ii??aiyeueia oa?aeoa?enoeea iaoe??io?a, ye? ca?eueieeeny a?ae IA i?ney EA IOO c oeie, ooi ?? caa??a. Iieacieee\iayai?noue IA A?euei? a?ae IA IA E?euee?noue iaoe??io?a 30 16 *ieia?e?a 19 (63,3%) 10 (62,5%) A?e (?ie?a) 48±12 56±17* I?aai?/ia iaoieia?y na?oey 5 (16,7%) 8 (50%)* AA 5 (16,7%) 6 (37,5%)* O?eaae?noue oeeeeo oao?ea?ae?? (in) 342±82 342±68 ?ici?? e?aiai ia?aaena?aey (ii) 32±19 46±17* OA (%) 55±19 47±14* Caa?aaeaiiy o?aceeaino? ia?aaena?aeue i?ney EA 7 (23,3%) 13 (81,2%)** I?ei?oee: * p<0,01; ** p<0,001 38,5% /ieia?e?a) iaoe??ioaie, ye? aei EA IOO iino?eii ? aoaeoeaii i?eeiaee aaoa-aeieaoi?aie (25) /e aioaaii?noaie eaeueoe?th (14) o ca’yceo c iayai?noth a ieo AA oa//e ?ON. 38 c 39 (97,4%) aaaaeaee, ui EA caaeaea iiceoeaiiai aieeao ia noai ?o caei?ia’y. E?euee?noue caa?oaiue ca iaaee/iith aeiiiiiaith (aeeth/ath/e a?ceoe aei e?ea?y, noaoe?iia?ia e?eoaaiiy oa a?eaaaee oaeaeei? aeiiiiiae) cieceeany c 8,3(3,1 aei 4,2(3,2 ia ??e (p<0,002). C iaeyaeo ia oa, ui iaoe??ioe i?eeiaee ??ci? aaoa-aeieaoi?e, ?ic?aooaaoe na?aaeiueiaeiaiao aeico ia aoei iiaeeeaei. Ui ae aei aa?aiaieeo, eiai na?aaeiueiaeiaiaa aeica cieceeany c 286(78 aei 261(92 ia, p<0,05. A?aeiinii 9 (23,1%) iaoe??io?a c AA oa?ai?y aoea ci?iaia ? iiaeaeueoiai eiio?ieth a?oa??aeueiiai oeneo aaeaeiny aeinyaoe ?ia?a?oi?aie AIO. Na?eici? oneeaaeiaiiy iioyaee 19 (3,9%) ao?o/aiue. ?o aeaoaeueio oa?aeoa?enoeeo iiaeaii o oaaeeoe? 7. E??i oiai, iaee i?noea 40 (8,3%) “iaeeo” oneeaaeiaiue, ye? i?aaenoaaeai?, aieiaiei /eiii, aaiaoiiaie a i?no? ioieoe?? (19) oa aaaaoaoeaieie ?aaeoe?yie ia ioieoe?th /e aeoyaiaiiy ?io?iae’thna??a (16), ye? ia iio?aaoaaee niaoe?aeueieo ae?aaiinoe/ieo ? e?eoaaeueieo ai?aa. Na?aae iaoe??ioe, ui iaee oneeaaeiaiiy, ia?aaaaeio /anoeio neeaee ae?iee (70% i?ioe 40% a i?aea?oi? aac oneeaaeiaiue, p<0,01). Oe? iniae aoee noa?oeie ca oeo, ui ia iaee oneeaaeiaiue (67(12 i?ioe 51(21, p<0,002). Oaaeeoey 7. Na?oeaai-noaeeii? oneeaaeiaiiy iia’ycai? c i?ioeaaeo?ith EA Oneeaaeiaiiy E?euee?noue Oneeaaeiaiiy ioieoe?? a?oa??iaaiicia o?nooea 3 (0,6%) Oneeaaeiaiiy aaciina?aaeiuei iia’ycai? c iai?ioeyoe?yie eaoaoa?aie /e EA ia?oi?aoe?y i?iea?ae?aeueii? no?iee 4 (0,8%) Oaiiiiaaea 3 (0,6%) ia?eea?ae?aeueiee aei?o 1 (0,2%) aeenaeoe?y a?oa??aeueii?/ai?oaeueii? no?iee 1 (0,2%) ?ic?ea aaiicii? no?iee 1 (0,2%) AA aeieaaea II-III nooiaith 4 (0,8%) Oneeaaeiaiiy ?aiiueiai ia??iaeo o?iiaiaiaie?? 4 (0,8%) eaaaiaai? a?oa??? 3 (0,6%) Oea?aa?aeueia 1 (0,2%) aeeiai?/ia ii?ooaiiy iiceiaiai e?iaiia?ao 1 (0,2%) aaiiciee o?iiaic 1 (0,2%) noao?a?ee?oao i?ioyaii 1-4 ae?a i?ney EA Anueiai 19 (3,9%) iio?aaoaaee o??o?a?/iiai ao?o/aiiy, yea aoei i?iaaaeaia 3 (0,6%) Nia?oi?noue 2 (0,4%) Aeniiaee Aenieiaia?aaoe/ia ANEA ia ia? ia?aaaa iaae ciai?oiueith EA. Iecueeiaia?aaoe/ia ANEA a?oaciei ?ic?yaeii ? aenieiaoaeoeaiith aeey a?aeiiaeaiiy N? o iaoe??io?a c IA, ?acenoaioiith aei ciai?oiuei? EA ? iiaea, e??i oiai, c oni?oii aeei?enoiaoaaoeny i?ae /an aioo??oiueina?oeaaeo i?ioeaaeo? aeey ae?i?iaoe?? iaaaaeaii? no?eei? IA. Oa?iaeieia?/ia EA IA oa OI ai?iaea?iiii a iaaaioaaeoaaeuei?e aeic? 22,4 a ? aoaeoeai?oith ca cae/aeio 12,6 a i?e iaeaea iaeiaeia?e ia?aiineiino?. Oaea aeica caeaoia a?aeiiaeoe N? o 50% iaoe??io?a c OI, ?acenoaioiei aei *NAN. I?io?eaeoe/ia oa?ai?y ai?iaea?iiii ca?eueith? a?ae neiioiiaoe/ii? IA a?eueoo /anoeio iaoe??io?a, yeui aeei?enoiaothoueny i?aeo?eioth/? aeice 300-400 ia\aeia. Oae? aeice, i?ioa, iiaaii ia?aiinei?, oae ui /a?ac 3 ?iee oa?ai?th i?iaeiaaeo? eeoa 1\3 iaoe??io?a. Oa?ai?y aeeciie?aieaeii i?/ii? IA ? aenieiaoaeoeaiith oa aacia/iith. IA ??aeei cono??/a?oueny na?aae iaoe??io?a c EAA- aeieoiaioiaaiith ?ON. I?ia?aeii? ?ie? o?ii?/ii? ia?aaena?aeii? ?oai?? a aaiac? IA a oe?e a?oi? ia i?aeoaa?aeaeaii. O iaoe??io?a c ?ao?aeoa?iith iino?eiith IA, EA AA c'?aeiaiiy ? iaoiaeii aeai?o. Aiaeiea?ae?aeueia noeioeyoe?y ia ia? ia?aaaa iaae /a?acno?aaioiaeioth a?aeiinii oa?i?iaoe?? ia?nenooth/iai OI. Iiia?aaeiy ae?aeoae?caoe?y iia??oo? ?acoeueoaoe noeioeyoe??. ?noion-aaeyoe?y aeicaiey? ca?eueieoe a?ae OI cia/io /anoeio iaoe??io?a, aea i?ney EA a ieo /anoi c’yaey?oueny ia?ieneciaeueia IA. EA ? iaoiaeii aeai?o a e?eoaaii? iaoe??io?a c AA oao?ea?ae?yie. Eiai ia?aaaae caa??aathoueny ? o iaoe??io?a, o yeeo iayai?noue na?oeaai-noaeeiii? iaoieia?? aeiaaa? iino?eii? oa?ai?? i?aia?aoaie ?? /e IV eean?a, iacaeaaeii a?ae ae?i?iaoe?? oao?ea?ae??. I?ney EA ?aoeeaeeae AA oao?ea?ae?e a?aeaoaathoueny o 4-10% iaoe??io?a. A ?ac? ?o aeieeiaiiy iieacaia iiaoi?ia ao?o/aiiy. *anoioa oneeaaeiaiue EA c?inoa? c a?eii iaoe??io?a. I?aeoe/i? ?aeiiaiaeaoe?? EA ? iaoiaeii aeai?o o e?eoaaii? iaoe??io?a c neiioiiaoe/ieie AAO, aac iaiaaeaiue iia’ycaieo ?c a?eii /e iayai?noth na?oeaai-noaeeiii? iaoieia??. Iacaeaaeii a?ae iaoai?cio EA IO ia? aenie? oaine ia i?ioeaaeo?aeueiee oa ee?i?/iee oni?o o iaoe??io?a aac IA.O ca’yceo c ??cieie aoaeoeai?noth oa ?eceeii EA o i?aaiio oa e?aiio ia?aaena?ae? ??oaiiy i?i EA IO iiaea aooe i?eeiyoei eeoa i?ney ?iaaceaiiai AOAe. EA OI iiaea aooe c oni?oii canoiniaaiith o e?eoaaii? iaoe??io?a c iiai?ioiei oeiiaei OI 1 oeio, ye? ia iathoue IA a aiaiiac? ? oa?aeoa? nea?a ia aea? i?aenoaae i?eionoeoe ?? ?nioaaiiy. I?iaaaeaiiy EA ?noiono ia oii? N? c canoinoaaiiyi noeioeyoe?? i?aaiai ia?aaena?aey aeey aeieaco ?noion-aeieo, ye ?? ?acoeueoaoo ? i?inoei ? iaae?eiei iaoiaeii, yeee ia? yai? ia?aaaae ia?aae EA ?noiono ia oii? OI. A ?ac? EA OI iaoe??ioe iiaeii? aooe ?ioi?iiaai? i?i aenieee ?ecee caa?aaeaiiy /e iiyae IA i?ney i?ioeaaeo?e. *NAN ? iaoiaeii aeai?o aeey i?eieiaiiy OI I oeio. Aoaeue-ye? AAI 1 eeano iiaeooue aooe c ??aiei oni?oii aeei?enoai? ia?aioa?aeueii aeey i?aeaeuaiiy aoaeoeaiino? *NAN. A ?ac? iaiiaeeeaino? oaeaeeiai i?iaaaeaiiy aeaeo?e/ii? 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III iiaeia?iaeiii eiioa?aioeii "O?aioeiy oa Oe?aiia, iaoeiai-i?aeoe/iee aeinaiae o eiioaenoi aeiaeiao iaoeiiiaeueieo eoeueoo?. - Aeiai?iiao?iane. - 1996. - O.2., *.4.- N. 16-17. Iaaeia I., I?aainoaeiae/ N., Eieoei N., Iaeneiaiei N., Aiiniaa I., sseiaeaaa I. I aiciiaeiinoe iaiaaeeeaiaioiciie ei??aeoeee ?eoia na?aeoea o iaoeeaioia n o?iie/aneie ia?oeaoaeueiie a?eoieae// Oac. III iiaeia?iaeiii eiioa?aioeii "O?aioeiy oa Oe?aiia, iaoeiai-i?aeoe/iee aeinaiae o eiioaenoi aeiaeiao iaoeiiiaeueieo eoeueoo?. - Aeiai?iiao?iane.-1996.-O.2.-*.4.-N. 15-16. Eieoei N.E. ?aaeei/anoioiay eaoaoa?iay aaeyoeey a ea/aiee ia?ooaiee ?eoia na?aeoea // Aeooaeueiua aii?inu iaiaaeeeaiaioiciiai ea/aiey caaieaaaiee i?aaiia aeuoaiey, na?aea/ii-ninoaeenoie e ia?aiie nenoaiu. Iaoa?eaeu Oe?aeineie iao/ii-i?aeoe/aneie eiioa?aioeee n iaaeaeoia?iaeiui o/anoeai. *anoue 1. - sseoa. - 1996. - N. 74-75. Aecye A.A., Ei?ieeiaa N.I., Eieoei N.E., I?aainoaeiae/ N.I., Aanee’?aa E.?. 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E aii?ino i oaeoeea aaaeaiey iaoeeaioia n aica?aoiui o?aiaoaieai i?aaena?aeee// Iaoa?eaeu iao/iie eiioa?aioeee, iinayuaiiie 100-eaoeth Naieo-Iaoa?ao?aneiai Ainoaea?noaaiiiai iaaeeoeeineiai oieaa?neoaoa ei. Iaaeiaa.-8-11.12.1997.- N. 93. Eieoei N. ?io?aea?ae?aeueia ea?ae?iaa?n?y aeey a?aeiiaeaiiy neioniaiai ?eoio o oai?eo c ieaioeeaith a?eoi??th, ?acenoaioiith aei ciai?oiuei? ea?ae?iaa?n??// ?ioi?iaoe?eiee eeno ?2.1997. Eieoei N.E., I?aainoaeiae/ N.A., Aiiaea?aiei I.A., Aecye A.A. Oa?aiey aaaon-caaeneiie ia?oeaoaeueiie a?eoiee aeeciie?aieaeii // Aanoiee a?eoiieiaee. - NIa, 1998. - ?8 - N. 55. I?aainoaeiae/ N.A., Eieoei N.E., Aiiaea?aiei I.A., Aecye A.A. Eeeie/aneia oa/aiea ?aoeei?ieiuo ia?ieneciaeueiuo AA oaoeea?aeee // Aanoiee a?eoiieiaee. - NIa, 1998. - ?8 - N. 11. I?aainoaeiae/ N., A?eai?aiei TH., Iaeneiaiei N., Eieoei N., Aiiaea?aiei I., Aecye A. I'yoe??/iee aeina?ae aeei?enoaiiy ?aae?i/anoioii? aaeyoe?? aeey ei?aeoe?? ii?ooaiue na?oeaaiai ?eoio //Oace aeiiiaiaeae VI iaoeiai? eiioa?aioei? Anioeiaoei? na?oeaai-noaeeiieo oi?o?aia Oe?a?ie. Ee?a, 1998.-N.192-193. Lokshin S., Dzjak G., Pravosudovich S., Maximenko S., Dzjak V. Ventricular rate control in chronic atrial fibrillation AV junction ablation or drug treatment? // Abstr. 13th World Congress on Cardiology. Rio-de-Janairo. 26-30.04.1998. Abstr.#0171. Mewis C., Kuehlkamp V., Lokshin S. et al. The slow pathway exhibits a higher adenosine-sensitivity compared to the fast pathway in patients with dual AV nodal physiology // PACE.-1999.-V.22, ?6,Part II.-?.A14. Lokshin S., Prog R. Atrial fibrillation in hypertensive patients: the ambulatory monitoring study //J.Hypertension.-1999.-V.16.-Abstr?133. Aecye A.A., I?aainoaeiae/ N.A., Eieoei N.E. Ea?aeeiaa?ney ia?nenoe?othuae eaeeiiaoe/aneie ia?oeaoaeueiie a?eoiee aac i?aaeaa?eoaeueiie aeeeoaeueiie aioeeiaaoeyoeee //Oace ia’?aeiaiiai ieaioio ea?ae?ieia?a, ?aaiaoieia?a oa ea?ae?io??o?a?a Oe?a?ie c i?aeia?iaeiith o/anoth. 6-8 aeiaoiy, Ee?a.-1999.-N.82-83. AIIOAOe?ss Aeena?oaoe?th i?enay/aii ieoaiiyi oa?ai?? iaaeoeoii/eiaeo oao?a?eoi?e. Ia iniia? aiae?co ?acoeueoao?a canoinoaaiiy ??cieo oa?iaeieia?/ieo oa iaoa?iaeieia?/ieo oa?aiaaoe/ieo no?aoaa?e ?ic?iaeai? i?aeoiaee aei e?eoaaiiy ??cieo IOOA. Noai?ai? aeai?eoie oa?ai?? ieaioeeai? a?eoi??. Anoaiiaeaii, ui a iaoiaaiac? IA o oai?eo ia ?ON ?ieue nenoie?/ii? aeenooieoe?? e?aiai oeoii/ea ? cia/i?oith ca ?ieue o?ii?/ii? ia?aaena?aeii? ?oai??. Aea/aii ?acoeueoaoe aioo??oiueina?oeaai? EA. I?iaeaiiino?iaai? aeniea aoaeoeai?noue ? aacia/i?noue ea?ae?iaa?n?? ia?nenooth/i? IA aaeeeeie aeicaie ai?iaea?iio oa ?acoeueoaoe o?eaaei? oa?ai?? iaoe??io?a c iiai?ioiith IA eiai na?aaei?ie aeicaie, ni?yiiaaii? ia iiaio ?? noi?an?th. I?iaeaiiino?iaaii aoaeoeai?noue oa aacia/i?noue eaoaoa?ii? aaeyoe?? ??ciiiai?oieo ?aaoey?ieo IOOA oa c’yniaaii ?? ia?aaaae iaae oa?iaeieia?/iith oa?ai??th a niaoeeo?/ieo a?oiao iaoe??io?a (oai?eo c ?ON, a?ia?oaic??th, iiai?ioiith IA). Cai?iiiiiaaii iiaee niin?a iiaeeo?eaoe?? AA i?iaaaeaiiy, yeee i?aeaeuo? aacia/i?noue EA. Iniiai? ?acoeueoaoe i?aoe? ai?iaaaeaeai? a ?iaioo e?ea?aiue oa aeeth/ai? a iaa/aeuei? iaoa??aee AOC?a. AIIIOAOeEss Aeenna?oaoeey iinayuaia eco/aieth eeeie/aneeo iniaaiiinoae ?acee/iuo iaaeaeaeoaei/eiauo oaoea?eoiee (IAEOA) e ?aoeeiiaeecaoeee iiaeoiaeia e eo ea/aieth. Ia aieueoii oaeoe/aneii iaoa?eaea i?iaiaeece?iaaia /anoioa ano?a/aaiinoe ?acee/iuo eieaeecaoeee aeiiieieoaeueiuo iooae i?iaaaeaiey e no?oeoo?a ia?ieneciaeueiuo IAEOA o iaoeeaioia n ieie. Eco/aia no?oeoo?a ea?aeeiaaneoey?iie iaoieiaee, annioeee?iaaiiie n ?acee/iuie IAEOA. Onoaiiaeaii, /oi a iaoiaaiaca IA o aieueiuo EAN ?ieue nenoiee/aneie aeenooieoeee eaaiai aeaeoaei/ea aieaa cia/eoaeueia, /ai ?ieue o?iie/aneie i?aaena?aeiie eoaiee. Aeaoaeueii i?iaiaeece?iaaiu ioneiaua oaeoi?u aicieeiiaaiey IAEOA e eieoeeaoeee ia?ieneciia. Ia iniiaa aiaeeca ?acoeueoaoia i?eiaiaiey oa?iaeieiae/aneeo e iaoa?iaeieiae/aneeo oa?aiaaoe/aneeo no?aoaaee ?ac?aaioaiu iiaeoiaeu e ea/aieth ?acee/iuo IAEOA. Nicaeaiu aeai?eoiu oa?aiee ia?oeaoaeueiie a?eoiee (IA). Eco/aiu ?acoeueoaou aioo?ena?aea/iie ea?aeeiaa?nee (EA). I?iaeaiiino?e?iaaia aunieay yooaeoeaiinoue e aaciianiinoue EA ia?nenoe?othuae IA aieueoeie aeicaie aiei?aea?iia e ?acoeueoaou aeeeoaeueiie oa?aiee iaoeeaioia n aica?aoiie IA aai n?aaeieie aeicaie, iai?aaeaiiie ia iieioth aa noi?anneth. A n?aaieoaeueiii enneaaeiaaiee aeieacaia eneeth/eoaeueii aunieay yooaeoeaiinoue aeeciie?aieaea o iaoeeaioia n ii/iie aaaoniie IA. Iieacaia yooaeoeaiinoue i?ioeaiainiaeeoaeueiie oa?aiee o iaoeeaioia n ?acenoaioiie e aioea?eoie/aneie oa?aiee IA aac eaai?aoi?iuo i?eciaeia ainiaeaiey. I?iaeaiiino?e?iaaiu yooaeoeaiinoue e aaciianiinoue eaoaoa?iie aaeyoeee (EA) ?acee/iuo ?aaoey?iuo IAEOA e onoaiiaeaiu aa i?aeiouanoaa iaae oa?iaeieiae/aneie oa?aieae a niaoeeoe/aneeo a?oiiao iaoeeaioia (eiathueo EAN, a?oa?eaeueioth aeia?oaiceth, aica?aoioth IA). I?aaeeiaeai iiaue niinia iiaeeoeeaoeee AA i?iaaaeaiey, eioi?ue iiauoaao aaciianiinoue EA. Eco/aiu oaeoi?u ?enea ?aoeeaeeaia oeie/iiai o?aiaoaiey i?aaena?aeee iinea oniaoiie enoion-aaeyoeee e ?aoeeaeeaia oeie/iie AA oceiaie oaoeea?aeee iinea iiaeeoeeaoeee AA i?iaaaeaiey. I?iaaaeai aiaeec oaeoi?ia, iaoneiaeeaathueo nio?aiaiea ia?oeaoaeueiie a?eoiee iinea oniaoiie eaoaoa?iie aaeyoeee ?aaoey?iie oaoeea?aeee. Iniiaiua ?acoeueoaou aeenna?oaoeee aiaae?aiu a ?aaioo aieueieoe e aeeth/aiu a o/aaiua iaoa?eaeu AOCia. SUMMARY The dissertation is devoted to design frontier topics in the therapy of supraventricular tachycardias (SVT). Based on results of some pharmacological and nonpharmacological treatment strategies, algorithms of the treatment of atrial fibrillation (AF) have been made. There is established that left ventricular systolic dysfunction is more important in a genesis of atrial fibrillation (AF) in patients with coronary artery disease than chronic atrial ischemia. The results of an intracardiac cardioversion have been investigated. The high efficacy and safety of the use of high doses of amiodarone for cardioversion of persistent AF and its middle doses for AF prophylax aimed to fully supress the arrhythmia. The efficacy and safety of catheter ablation of different SVT has been demonstrated and prevalence of this method above drug therapy among some special patients groups (coronary artery disease, arterial hypertension, recurrent AF) as well. A new method of AV conduction modification, which increases of catheter ablation safety is proposed. The main dissertation results have found an utility in some hospital work and are integrated in some high school learning programs. ?en. 1. Aeeiai?ea iaaeeei-nioe?aeueieo iieaciee?a i?ney eaoaoa?ii? aaeyoe?? ? ea?ae?iaa?n?? o??iio?iiy ia?aaena?aeue

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