?INOEOOO AA?IIOIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

IAIANAIEI Ia?aa?eoa A?eoi??aia

OAeE 577.12 — 175.446:612.014:616 — 092.4

INIAEEAINO? ACA?IIA?AeIINEI EAEUeOeEOII?IO

OA AIAeIAAIIEO II?I?Ae?A I?E NA*IEAI’I?E OAI?IA?.

03.00.04 — a?io?i?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoeiai-aeine?aeieoeueeiio oeaio?? Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iaoeiaee ea??aiee: Eiia?aaoeaaa ??eia Ieaenaiae??aia, aeieoi? iaaee/ieo
iaoe, i?ioani?, caa?aeoaa/ea eaoaae?e iaaee/ii? o?i?? Eoaainueeiai
aea?aeaaiiai iaaee/iiai Oi?aa?neoaoo

Io?oe?ei? iiiiaioe: Eiiiiaiei Aeaaeeneaa sseiae/, aeieoi? iaaee/ieo
iaoe, i?ioani?, caa?aeoaa/ eaai?aoi??? iae?io?i?? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i.A.I.Eii?na?aiea AII Oe?a?ie,
i.Ee?a.

A?iiia Eaii?ae Ieaenaiae?iae/,
aeieoi? iaaee/ieo iaoe, i?ioani?, caa?aeoaa/ eaai?aoi???
iae?ioa?iaeieia?? ?inoeoooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie,
i.Ee?a

I?ia?aeia onoaiiaa: ?inoeooo a?io?i?? ?i. I. A. Iaeeaae?ia IAI Oe?a?ie
(a?aeae?e a?io?i?? naini?ieo ? ?aaoeyoi?ieo nenoai).

Caoeno a?aeaoany «23» aa?aniy 1999 ?. i 10 aiaeei? ia

can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.551.01 a ?inoeooo?
aa?iioieia?? AII

Oe?a?ie (252114, i.Ee?a, aoe.Aeoai?iaenueea, 67).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
aa?ioieia??

Aaoi?aoa?ao ?ic?neaiee «7»na?iiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee
Iioaiaiei ?. ?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

Aeooaeuei?noue oaie.A?io?i?/ia oa o?ceieia?/ia cia/aiiy eaeueoe?th
iaaeoi ??ciiiai?oii, ui iaoiiaeth? iiiaeeii?noue ee?i?/ieo i?iya?a
iaoieia?? eiai iai?io (Dzhavad-Zade S. M., Abdulaev S. Sh., 1998;
Mazzocchi G., et al., 1998; Pearse S., Brown E. M., 1996).

Ie?ee ? iniiaiei i?aaiii, ?aaoethth/ei eiioeaio?aoe?th iniioe/ii
aeoeaieo ?a/iaei a e?ia?, ia’?i ??aeeie, eiioeaio?aoe?th eiaeiiai c
?ii?a, eeneioii-eoaeio ??aiiaaao. An? ooieoe?? ie?ee ciaoiaeyoueny i?ae
iae?iai?iiiaeueiei eiio?ieai. Naia ae ie?ea ae?iaey? a?ieia?/ii aeoeai?
?a/iaeie, ui aa?ooue o/anoue o i?aeo?eiaii? aiiainoaco. Oiio,
aoaeue-yeee iaoieia?/iee i?ioean, ui ca/?ia? ie?eo, aaaea aei c?ooaiiy
aiiainoaco e eaioethaa iaoieia?/ieo c?ooaiue a i?aai?ci? a oe?eiio. A
oie aea /an iiaeeo?eaoe?y a ai?iiiaeueiiio niaeo?? aaaea aei
iaoieia?/ieo i?ioean?a a ooieoe?iioaaii? ie?ee.

Iacaaaeath/e ia anaa?/io oaaao aeine?aeiee?a aei eaeueoe?th i?ioyaii
aaaaoueio ?ie?a, ?aaiethoe?eia a?aee?eooy Brown E. ? Pollak M. (1998)
iicaee?oeiieo eaeueoe?e-/ooeeaeo ?aoeaioi??a a ie?eao oa ?ioeo oeaieiao,
aeicaieythoue ?icaeyaeaoe eaeueoe?e a yeino? ia?aeiiiai ianaiaeaea?a (a
aeiiiaiaiiy aei a?aeiii? eiai ?ie? aoi?eiiiai aioo??oiueiee?oeiiiai
ianaiaeaea?a), ui ?ice?eaa? iia? ai?eciioe o aea/aii? eaeueoe?th oa eiai
?aaoeyoi?ieo nenoai.

Na?aae ai?iii?a, ui aa?ooue o/anoue a i?aeo?eiaii? eiioeaio?aoe?? Na++ a
e?ia?, iaio anueiai aeine?aeaeaiei ? eaeueoeeoii?i (EO). Iaea?eueo yaiee
aoaeo eaeueoeeoii?io iieyaa? a i?eaiiaethaaii? ?aci?aoe?? e?noee.
Eaeueoeeoii?i aaeueio? aeo?ae i?aai?/ieo ?a/iaei c e?noeiaiai iao?eeno,
??aii ye ? i?ia?aeueieo eiiiiiaio?a e?noee. Oea i?ecaiaeeoue aei
cieaeaiiy ??aith a?ae?ien?i?ie?io, eaeueoe?th e oinoaoo a na?aaeiaeu?.
Ae?oaei i?aaiii-i?oaiith eaeueoeeoii?io ? ie?ee. A ie?eao a?i i?aeaeuo?
aene?aoe?th eaeueoe?th, iao??th e oinoaoo (?yaia N. ?., Iaoi/ei TH. A.,
1997). Iniiaiei noeioeii nae?aoe?? EO ? i?aeaeuaiee ??aaiue eaeueoe?th a
ne?iaaooe? e?ia?. A?aeiii, ui aeaye? ai?iiie oeoieiai-eeoeiaiai o?aeoo,
iniaeeai aano??i, oaeiae noeioeththoue nae?aoe?th EO. Aeai? Eoia?a oa
?i. (Cooper et al., 1971), ca?aeii yeei, nae?aoe?th EO iiaeia aeoeaoaaoe
ia?i?aeueiei i?eeiaiiyi eaeueoe?th, ia aeeeeeath/ei aeaeeieo
iiaeeo?eaoe?e eiai eiioeaio?aoe?? a ieaci?, i?aeoaa?aeaeothoue iiaeyae,
ui [Na++] (i?e eieeaaiiyo a iaaeao ii?ie) ia a?aeiineoueny aei /enea
iniiaieo neaiae?a nae?aoe?? eaeueoeeoii?io. ?niothoue e?oa?aoo?i? aeai?
i?i aieea EO ia neioac oa nae?aoe?th i?inoaaeaiaeei?a e aiaeiaaiieo
ii?i?ae?a (Alfaro M. J., 1997; Ormazabal M. J., et al., 1997).

Iaaii, ie??i eiioeaio?aoe?? Na++ a e?ia? ? ai?iii?a oeoieiai-eeoeiaiai
o?aeoo (OEO) ?niothoue e ?io? oaeoi?e, ?aaoethth/? ??aaiue EO. Neiae?ii,
ui cono??/a?oueny a ee?i?oe? — a?ia?i?iaeoeoe?? i?inoaaeaiaeeio A2,
noi?iaiaeaeo?oueny a?ia?eaeueoeeai??th e ?icaeoeii iao?ie?o?aco
(Kockerling A., et al., 1998). Ine?eueee i?inoaaeaiaeeie ? oeaiaaeie
?aaoeyoi?aie aai ae?oaeie iina?aaeieeaie ae?? ai?iii?a, iiaeeeai, ui
IAA2 aeyaey? aieea ia ??aaiue EO a ieaci? e?ia?. A?aeiii, ui EO
a?aeiinyoue aei iae?iiaioeae?a, a a OeIN aeyaeai? ?aoeaioi?e aei
eaeueoeeoii?io. Ioaea, ia aeeeth/aiee aca?iica’ycie i?ae IAA2,
iao-aieaoae?iii e eaeueoeeoii?iii.

Ia ee?oeiiiio ??ai? i?ioean i?aeo?eiaiiy oe?e?niino? i?aai?cio
?aae?co?oueny ca ?aooiie ?aaoeyoi?iiai aieeao aoa?aioieo neaiae?a, ui
i?aeo?eiothoue ??aiiaaaeiee noai i?ae ?ioaa?aoeaieie o?c?ieia?/ieie
i?ioeanaie: i?ie?oa?aoe??th, aeeoa?aioe?thaaiiyi oa o?c?ieia?/iith
ee?oeiiith caaeaaeeth (Hammerman M. R., 1998; Sorenson C. M., 1998). Ca
inoaii? 10-15 ?ie?a io?eiaee oe?ieee ?icaeoie e aeciaiiy oyaeaiiy i?i
cia/i?noue eaeueoe?th aeey caaacia/aiiy ooieoe?iioaaiiy aeeaeo ee?oei
(Chevalier R. L., 1996). ?iie eaeueoe?th, oeeee?/i? ioeeaio?aee (oeAIO,
oeAIO) aeciai? a yeino? aioo??oiueiee?oeiieo iina?aaeiee?a a aaaaoueio
a?io?i?/ieo i?ioean?a.

Ee?i?/iith iiaeaeeth ii?ooaiiy iai?io eaeueoe?th e, iiaeeeai
eaeueoeeoii?io, ? na/ieai’yia oai?iaa (NEO) (Bushinsky D. A., 1998).
Iacaaaeath/e ia cia/io ?iciianthaeaeaii?noue na/ieai’yii? oai?iae oa
?nioaaiiy oae caaieo «eai’yieo iiyn?a», ao?ieia?y oa iaoiaaiac ??
caeeoa?oueny ia c’yniaaieie. A yeino? iniiaieo iaoiaaiaoe/ieo iaoai?ci?a
eaiaiaooai?aiiy aeciathoueny i?noeaa? oaeoi?e, ye oa: ?I na/?, ??
ia?aiane/aiiy ??ciiiai?oieie aeaeaie ?ii?a, ?ia?a?oi?e ia?aiane/aiiy
na/?, aeoeaaoi?e e?enoae?caoe?? ? c?inoaiiy e?enoae?a (Ruml L. A., 1997;
Goldfarb S., 1994). Ia iao iiaeyae iiae?aiee ?icaeyae NEO ? iiaa?oiaaei
? ia aeanoue iiaeeeaino? ee?i?oeenoo i?ae?eoe aei e?eoaaiiy aeaii?
oai?iae c iiceoe?? ao?iiaoiaaiaco. sse i?aaeei e?eoaaiiy iieyaa? a
i?ecia/aii? iecueeieaeueoe??ai? ae??oe. Ie aaaaea?ii, ui i?noeaa?
oaeoi?e na/? ? ne?aenoaii, a ia i?e/eiith oai?iae. NEO — oea ii?ooaiiy
iai?iieo i?ioean?a, aeeeeeaia ?ic?aaoethaaiiyi c aieo aiaeie?eiii?
nenoaie. A ine?eueee eaeueoe??a? eaiai? neeaaeathoue 80% an?o ie?eiaeo
eaiai?a, oi ne?ae ooeaoe ii?ooaiiy iai?io eaeueoe?th a i?aai?ci? a
oe?eiio (Roger K. L., 1997).

A ?acoeueoao? iaoieia?/ieo iiaeeo?eaoe?e, ui a?aeaoaathoueny i?e NEO,
oaeeo ye ii?ooaiiy ai?iiiaeueiiai niaeo?o, ?iiiiai neeaaeo a?ieia?/ieo
na?aaeiaeu, a?aeaoaa?oueny ? iiaeeo?eaoe?y o?ceei-o?i?/ieo aeanoeainoae
oeaieiii? aiaee i?aai?cio. Ii G. Fullerton ? niaao. (G. D. Fullerton, J.
L. Poter, 1982) aiaea a oeaieiao ?nio? o aeaeyae? aeaio o?aeoe?e:
a?eueii? ? ca’ycaii?. Ia?oa ?aeaioe/ia ii nai?i oa?aeoa?enoeeai /eno?e
aiae?. Ca’ycaia aiaea i?ee??ieaia aei iiaa?oi? iae?iiieaeoe ? iaia?ai
(oai??y iiey?eciaaii? aaaaoioa?iaino?). Ca’ycaia aiaea a naith /a?ao
iiae?ey?oueny ia aeaa ??ciiaeaee: niaoeeo?/ii aaeni?aiaaia aiaea, i?oeii
ca’ycaia c? no?oeoo?aie iae?iiieaeoe (e?enoaeueiaaia o?aeoe?y ii G.
Fullerton) ? «a?ae?iaaia» aiaea, ui aaeni?aiaaia ia iiaa?oi? a?iiieaeoe.
Iiaeeo?eaoe?y o?ceei-o?i?/ieo aeanoeainoae aiaee a a?ieia?/ieo
na?aaeiaeuao i?e ??ciiiai?oieo caoai?thaaiiyo ie?ie aia?oa aoee aea/ai?
iaie ca aeiiiiiaith iaoiaeo ssI?-?aeaeniiao???.

Ana aeeeaaeaia aeua e aecia/a? aeooaeuei?noue oaie aeaii? ?iaioe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?? ? o?aaiaioii eiieo?nii? aea?aeathaeaeaoii? oaie IIC Oe?a?ie
E 1\7.21.12.94 iaoeiai-aeine?aeieoeueeiai oeaio?o Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo «Aiaeiaaii? ii?i?aee oa aoii?aeueia
eaiea ooieoe?iiaeueii? aaeaioaoe?? ie?ie a ?aaoeyoe?? a?oa??aeueiiai
oeneo oa aiaeii-aeaeo?ie?oiiai aaeaino i?e anaioe?aeuei?e a?ia?oaic?? e
ie?eiai? iaoieia??» oa ieaiiai? aea?aeathaeaeaoii? oaiaoeee «Aieea
aeieia?/ii iaaacia/ieo oaeoi??a ia i?aai?ci a oiiaao i?iieneiaiai
?aa?iio oa ?ic?iaea iaoiae?a ei?aeoe?? iaoaaie?cio e ?ioaineaii?
oa?ai??» ? aea?aeaaii? ?a?no?aoe?? 01.9.10.033409.

Iaoa aeine?aeaeaiiy. Aecia/eoe aca?iica’ycie eaeueoeeoii?io oa
aiaeiaaiieo ii?i?ae?a a iae?iai?iiiaeuei?e ?aaoeyoe?? iai?io eaeueoe?th
e aeaeo?ieeo?a a ii?i? oa a aenia?eiaioaeueii-ee?i?/ieo iiaeaeyo
ii?ooaiiy aiiainoaco eaeueoe?th.

Caaea/? aeine?aeaeaiiy.

1.Aecia/eoe aieea o?ii?/iiai aaaaeaiiy IAA2 (aeoeaaoi?a inoaieeano?a) e
?iaeiiaoaoeeio ia ne?iaaoeia? ??ai? iao-aieaoae?io ? eaeueoeeoii?io a
ii??aiyii? c ai?noii Na++, Na+, E+ a ne?iaaooe? e?ia?, na/?, e?noeao
aei?ineeo oa iieiaeeo oaa?ei.

2. Anoaiiaeoe iniaeeaino? ae?? aiaeiaaiieo ii?i?ae?a, eaeueoeeoii?io,
aeciaaiieo i?inoaii?ae?a (IAA2) oa aeieaoi?o ?o neioaco – ?iaeiiaoaoeeio
ia ie?eiao oeaieio ii iieacieeai ssI?-?aeaeniiao??? i?ioii?a oeaieiii?
aiaee in vitro.

Aeine?aeeoe ??aaiue aieaoae?ia?a?/ii? ?aaoeyoe?? aeoeaiino?
a?iioaeaii-a?iio?ca?ii? (AAeA, AEOA, i?ieaeoei), ?ai?i-aeueaeinoa?iiiai?
nenoai e eaeueoeeoii?io i?e na/ieai’yi?e oai?ia? — ee?i?/i?e iiaeae?
ii?ooaiiy iai?io eaeueoe?th.

4. Aecia/eoe iieacieee ssI?-?aeaenaoe?? i?ioii?a oeaieiii? aiaee e?ia?,
ne?iaaoee, na/? o oai?eo ia na/ieai’yio oai?iao c eieae?caoe??th eaiai?a
a na/iaiae?, ie?eia?e ienoe?, na/iaiio i?oo??, NEO ?aeeii? ie?ee, oai?eo
ia o?ii?/iee i?aeiiao?eo, iie?eenoic ie?ie a c?noaaeaii? c
eiioeaio?aoe??th ?ii?a Na+, E+ a ne?iaaooe? e?ia? e na/?, oa
iiaeeea?noue aeei?enoaiiy aeaiiai iaoiaeo ye ia?ea?a aeey ae?aaiinoeee
ie?eiai? iaoieia??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aoa aeine?aeaeaiee
aieea aeciaaiiiai IAA2 oa ?iaeiiaoaoeeio ia ??ai? eaeueoeeoii?io oa
iao-aieaoae?io a c?noaaeaii? c eiioeaio?aoe??th aeaeo?ie?o?a Na++, Na+,
E+ a ne?iaaooe? e?ia?, e?noeao oa na/? a iioiaaiac?.

Aia?oa aea/aia ?ieue aiaeiaaiieo ii?i?ae?a ? eaeueoeeoii?io a
iae?iai?iiiaeueieo iaoai?ciao iaoiaaiaco na/ieai’yii? oai?iae o
ii??aiyii? c ai?iiiaeueiei niaeo?ii i?e ?ioeo caoai?thaaiiyo ie?ie —
i?aeiiao?eo?, a?ae?iiao?ic?, eeno? ie?ee, iie?eenoic?, iooeei? ie?ie, ui
aeicaieeei eeaneo?eoaaoe ee?i?/i? a?oie c a?aooaaiiyi ai?iiiaeueiiai
noaoono.

Aia?oa aeine?aeaeoaaany ??aaiue eaeueoeeoii?io o aeeoae?a Eoaainueei?
iaeano?, ui ? aiaeai?/iith ii na/ieai’yi?e oai?ia? o ii??aiyii? ?c
??aiai oeueiai ai?iiio o aeeoae?a ?ioeo ?aa?ii?a. Oaeiae aea/aany
??aaiue eaeueoeeoii?io ieacie e?ia? o oai?eo ia na/ieai’yio oai?iao a
ii??aiyii? c? caei?iaeie aeiii?aie.

Aia?oa aeine?aeaeai? O1 — ? O2-iieacieee /an?a ?aeaenaoe?? i?ioii?a
oeaieiii? aiaee e?ia?, ne?iaaoee oa na/? oai?eo ia na/ieai’yio oai?iao
c ??ciith eieae?caoe??th eaiai?a o ii??aiyii? c ?ioith iaoieia??th
ie?ie, ui aeicaieeei noai?eoe aaco aeaieo ae?aaiinoe/ieo e?eoa???a
ssI?-oa?aeoa?enoee aeey ie?eiai? iicieia??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iaie cai?iiiiiaaii
eeaneo?eoaaoe ee?i?/i? a?oie iaoieia?? ie?ie c o?aooaaiiyi
ai?iiiaeueiiai noaoono; aeyaeoe a?oie i?aeaeuaiiai ?eceeo e ?ic?iaeoe
ae?aaiinoe/i? e?eoa??? ?aiiuei? ae?aaiinoeee o?ie?o?aco, aeei?enoiaoth/e
i?e oeueiio iaoiaeeeo ssI?-?aeaeniiao???.

A?aoiaoth/e ?acoeueoaoe iaoeo aeine?aeaeaiue, ie i?iiiio?ii noaio
iaoiaaiaco na/ieai’yii? oai?iae, a?aei?iio a?ae ?ai?o cai?iiiiiaaieo
o?aaeeoe?eieo noai. A ca’yceo c oeei iiaeeeaee iiaee iai?yiie a
eiina?aaoeaiiio e?eoaaii? o?ie?o?aco, iiia?aaeaeaiiy ?aoeeaeea?a oa
oneeaaeiaiue aeaiiai caoai?thaaiiy. E iaeaieiai?oa — oea ae?aaiinoeea
aeiee?i?/ieo oi?i e iiia?aaeaeaiiy ooai?aiiy ie?eiaeo eaiai?a.

Iniaenoee aianie caeiaoaa/a. ?iaioa aeeiiaia aaoi?ii naiino?eii. Aaoi?
naiino?eii i?iaiaeeea aenia?eiaio ia uo?ao oa ianoaaeaiiy iaoe??io?a c
iaoieia??th ie?ie, aeeiioaaea ?aae?i?ioii? aiae?ce, ssI?-niaeo?ineii?th.
Naiino?eii aoa i?iaaaeaiee iaoaioiee iiooe, aiae?c a?o/eciyii? oa
ca?oa?aeii? e?oa?aoo?e ii oai? aeena?oaoe?eii? ?iaioe. Aeena?oaio
i?iaaea noaoenoe/io ia?iaeo aeaieo c aeei?enoaiiyi ia?niiaeueiiai
eiii’thoa?a, i?iaiae?coaaea iaea?aeai? ?acoeueoaoe.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?acoeueoao?a
aeena?oaoe?? aoee iaaiai?ai? ia XV c’?cae? Oe?a?inueeiai o?c?ieia?/iiai
oiaa?enoaa; ia IV i?aeia?iaeiiio eiia?an? iieiaeeo a/aieo ?
nooaeaio?a-iaaeee?a; ia i?aeeaoaae?aeueiiio can?aeaii? ?ia?oiee?a
eaoaae?e iaaee/ii? o?i?? oa iaoeiai-aeine?aeieoeueeiai oeaio?o
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ioae?eaoe??. Iaoa??aee aeena?oaoe?? iioae?eiaai? a noaooyo /ioe?ueio
iaoeiaeo aeo?iae?a oa a iaoa??aeao aeaio iaoeiaeo eiioa?aioe?e.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 153 ae?oeiaaieo
noi??ieao. I?noeoue anooi, iaeyae e?oa?aoo?e, ?icae?e «iaoa??aee oa
iaoiaee aeine?aeaeaiiy», ?icae?e ?acoeueoao?a aeanieo aeine?aeaeaiue,
caeeth/aiiy oa aeniiaee. ?iaioa ?ethno?iaaia 22 iaethieaie oa 10
oaaeeoeyie. Nienie e?oa?aoo?e aeeth/a? 260 aeaea?ae.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Aenia?eiaioaeueia /anoeia ?iaioe
aoea i?iaaaeaia ia 114 uo?ao -naioeyo e?i?? A?noa? /ioe?ueio, i’yoe-,
oanoe-, aeaa’yoeoeaeiaaiai, i’yoe-, i’yoe c iieiaeiith- oa oanoei?ny/iai
a?eo. Eiio?ieai eiaeiiai no?ieo aaaaeaiiy IAA2 neoaeea iaeiia?eiaee
eiio?ieue (60 uo??a). *ioe?ueiooeaeiaaei oa i’yoei?ny/iei uo?ai i?ioyaii
naie, /ioe?iaaeoeyo?, o?eaeoeyoe ae?a a /a?aaio ii?iaeieio aaiaeeany
aeciaaiiee IAA2 o o?c?ieia?/i?e aeic? 100 iea/ea. Oaa?eie caaeaaeenue
iaoiaeii aeaeai?oaoe??.

E?euee?nia aecia/aiiy iaoeii?i-aieaoae?io ? eaeueoeeoii?io a ne?iaaooe?
e?ia? i?iaaaeeeinue ?aae?i?ioiiei iaoiaeii iaai?aie o??i «Amersham»
(Aiae?y), «Incstar» (NOA). ??aaiue aeaeo?ie?o?a iao??th e eae?th
aecia/aany aiae?caoi?ii (AI?), eaeueoe?th — niaeo?ioioiiao?e/ii.

Ee?i?/ia /anoeia ?iaioe aoea i?iaaaeaia i?e aeine?aeaeaii? oai?eo
ianooiieo ee?i?/ieo a?oi: NEO c eieae?caoe??th eaiaith a na/iaiio
i?oo??, NEO c eieae?caoe??th eaiaith a ie?eia?e ienoe?, NEO c
eieae?caoe??th eaiaith a na/iaiae?, aeainoi?iiiy NEO, NEO ?aeeii? ie?ee,
o?ii?/iee i??eiiao?eo, o?ii?/iee i??eiiao?eo ?aeeii? ie?ee,
a?ae?iiao?ic, ?aeeia e?noa ie?ee, iie?e?noic ie?ie, iooeeia ie?ie
(anueiai 299 /ieia?e). Eiio?ieai neoaeeea a?oia caei?iaeo aeiii??a (162
ethaeeie) ia ae??o? c ii?iaeueiei oo?eiaiiyi iao??th (80-120
iiieue/aeia) o a?oe? 18-55 ?ie?a.

E?euee?nia aecia/aiiy iao-aieaoae?io, aacii?aneio, AEOA, i?ieaeoeio,
eaeueoeeoii?io, A?I, aeueaeinoa?iio a ieaci? e?ia? i?iaiaeeeiny
?aae?i?ioiiei iaoiaeii c aeiiiiiaith eiia?oe?eieo iaai??a o??i «Incstar»
(NOA), «CIS» (O?aioe?y), «Biilhmann Lab.» (Oaaeoea??y), «Amersham»
(Aiae?y), AI?.

I?ae?aooiie ?aae?iaeoeaiino? aoa aeeiiaiee ia noeeioeeyoe?eieo
?ao?aieeao «Aaia-1», «Aaoa-1».

Aei?? oo?eiaiiy aeaeo?ieeo?a a na/? e ne?iaaooe? e?ia? ae?iaeyee c
i?e?iaiae?caoi?o (AI?).

A ee?i?/i?e /anoei? iaoiai aeine?aeaeaiiy ie aecia/aee /ane ?aeaenaoe??
O1 (iiacaeiaaeiy) e O2 (iiia?a/ia) i?ioii?a oeaieiii? aiaee e?ia?,
ne?iaaoee e?ia? oa na/? o oai?eo ia ie?eiao iaoieia?th, ui
no?aaeaeathoue na/ieai’yiith oai?iaith, o?ii?/iei i??eiiao?eoii,
iie?eenoicii ie?ie.

A na/? e ne?iaaooe? e?ia? ie aecia/aee oo?eiaiiy iao??th e eae?th ca
aeiiiiiaith aeeae?i?e?iaiae?caoi?o (AI?).

Aieea o?ii?/iiai aaaaeaiiy aeciaaiiiai IAA2 oa ?iaeiiaoaoeeio ia
ieaciia? ??ai? eaeueoeeoii?io oa iao-aieaoae?io.

A iaoiio aenia?eiaio? aaeeoa ni?iaa c’ynoaaoe aca?iiae?th IAA2,
eaeueoeeoii?io oa aiaeiaaiieo ii?i?ae?a. Oei a?eueo ian caoe?eaaeea oey
i?iaeaia, eiee a ee?i?/i?e /anoei? iaoi? ?iaioe aoee aeyaeai? a?oa?
ii?ooaiiy a iai?i? eaeueoeeoii?io oa aiaeiaaiieo ii?i?ae?a i?e NEO.

I?e aaaaeaii? IAA2 i?ioyaii 7 ae?a ??aaiue iao-aieoae?io a ieaci? e?ia?
o iieiaeeo uo??a cieaeoaaany o ii??aiyii? c iaeiia?eiaei eiio?ieai, a ia
14, 30 aeiao aaaaeaiiy eiai ??aaiue c?inoaa o ii??aiyii? c eiio?ieai oa
7 aeiaith aaaaeaiiy. Oa ae oaiaeaioe?y niinoa??aaeany e o aei?ineeo
oaa?ei (oaae. 1). Cieaeaiiy ??aiy iao-aieaoae?io ia 7 aeiao aenia?eiaioo
coiiaeaia i?eaiiaeaiiyi ae?iaeaiiy iao-aeaoae?io IAA2 ia ??ai? eiai
neioaco a a?iio?c?, ui i?aeoaa?aeaeothoue aeine?aeaeaiiy in vitro
(Vlaskovska M., Knepel W., 1987), a iiaeaeueoa c?inoaiiy ??aiy
iao-aieaoae?io ia 14, 30 aeiao iiynith?oueny i?eaiiaethaaiiyi ae?iaeaiiy
aiaeiaaiiiai IAA2 (i?eeeaae eeane/ii? ai?iiiaeueii? caeaaeiino?).

??aaiue EO ieacie o iieiaeeo uo??a aaea ia 7 aeiao aaaaeaiiy IAA2
cieceany o 2 ?ace o ii??aiyii? c iaeiia?eiaei eiio?ieai, oiae? ye o
aei?ineeo oaa?ei iaa iacia/io oaiaeaioe?th aei c?inoaiiy. Ia 14 aeiao o
iieiaeeo uo??a ??aaiue EO caeeoaany ieae/a eiio?ieueiiai iaeaea a 2
?ace, a aei 30 aeiae niinoa??aaeiny cia/ia c?inoaiiy eiai ??aiy o
ii??aiyii? c eiio?ieai, ui ca’ycaia c eaeueoe?ai?/iith ae??th IAA2 (Eea?
N., 1987), ? c? noeioethth/ei aieeaii iao-aieaoae?io (Neaiooeei A. Ae.,
Cieiaa A. E., 1988), ??aaiue yeiai oaeiae cia/ii c??n aei 30 aeiae
aenia?eiaioo. O aei?ineeo uo??a c?inoaiiy EO aoei cia/iei aaea aei 14
aeiae ? i?iaeiaaeoaaany ia 30 aeiao aenia?eiaioo (oaae. 1), ui
iiaiaeaeo?oueny c aeaieie e?oa?aoo?e i?i ni?iiiaei?noue IAA2 aeoeaoaaoe
inoaieeanoio aeoeai?noue e?noeiai? oeaieie e aeeeeeaoe oyaeeo
a?ia?eaeueoe?ai?th (Neaiooeei A. Ae., Cieiaa A. E., 1988; Akatsee T.,
Takahashi N., 1989). A iaoiio aenia?eiaio? oea i?aeoaa?aeaeo?oueny
c?ineei ??aiai eaeueoe?th a ne?iaaooe? e?ia? aei?ineeo uo??a,
i?aeaeuaiith eiai aene?aoe??th i?ioyaii anueiai aenia?eiaioo oa
cieaeaiiyi oo?eiaiiy eaeueoe?th a e?noeao c 7 ii 30 aeiao.

Oaaeeoey 1

Aieea o?ii?/iiai aaaaeaiiy IAA2oa ?iaeiiaoaoeeio ia ne?iaaoeia? ??ai?
iao-aieaoae?io e eaeueoeeoii?io o iieiaeeo oa aei?ineeo uo??a.

Iieacieee

No?iee aaaaeaiiy IAA2

Iao-aieaoae?i, ia/ie

Eaeueoeeoii?i, ia/ie

eiio?ieue

(n=10) aeine?ae

(n=9) eiio?ieue

(n=10) aeine?ae

(n=9)

Iieiae? oaa?eie

7 aeiaa 2000,0 SYMBOL 177 \f «Symbol» \s 14 ± 40,8 1334,2 SYMBOL 177 \f
«Symbol» \s 14 ± 26,4o 134,0 SYMBOL 177 \f «Symbol» \s 14 ± 4,6 65,3
SYMBOL 177 \f «Symbol» \s 14 ± 3,8o

14 aeiaa 1860,2 SYMBOL 177 \f «Symbol» \s 14 ± 56,4 2466,7 SYMBOL 177 \f
«Symbol» \s 14 ± 18,5o 96,8 SYMBOL 177 \f «Symbol» \s 14 ± 5,10 53,0
SYMBOL 177 \f «Symbol» \s 14 ± 2,2o

30 aeiaa 1962,1 SYMBOL 177 \f «Symbol» \s 14 ± 31,8 2966,7 SYMBOL 177 \f
«Symbol» \s 14 ± 19,0o 96,9 SYMBOL 177 \f «Symbol» \s 14 ± 4,8 156,25
SYMBOL 177 \f «Symbol» \s 14 ± 3,1o

Aei?ine? oaa?eie

7 aeiaa 1225,8 SYMBOL 177 \f «Symbol» \s 14 ± 28,60 981,7 SYMBOL 177 \f
«Symbol» \s 14 ± 16,6o 50,4 SYMBOL 177 \f «Symbol» \s 14 ± 5,60 72,08
SYMBOL 177 \f «Symbol» \s 14 ± 5,2o

14 aeiaa 954,0 SYMBOL 177 \f «Symbol» \s 14 ± 30,40 1110,0 SYMBOL 177 \f
«Symbol» \s 14 ± 15,4o 50,4 SYMBOL 177 \f «Symbol» \s 14 ± 5,60 242,0
SYMBOL 177 \f «Symbol» \s 14 ± 3,8o

30 aeiaa 912,0 SYMBOL 177 \f «Symbol» \s 14 ± 19,00 946,7 SYMBOL 177 \f
«Symbol» \s 14 ± 14,0 50,4 SYMBOL 177 \f «Symbol» \s 14 ± 5,60 113,17
SYMBOL 177 \f «Symbol» \s 14 ± 4,0o

o — p SYMBOL 163 \f «Symbol» \s 14 F 0,05 o ii??aiyii? c iaeiia?eiaei
eiio?ieai

0 — p SYMBOL 163 \f «Symbol» \s 14 F 0,05 a iioiaaiac? o ii??aiyii? c
4-o oeaeiaaeie uo?aie

Cieaeaiiy oo?eiaiiy iao??th a e?noeao iiaiaeaeo?oueny c aeaieie i?i
iao??eo?aoe/io ae?th IAA2 (Quito F. L., 1987). ?iaeoa ?iciiae?eythoueny
aeaeo?ie?oe o iieiaeeo oaa?ei, aea niinoa??aaeany a?iieaeueoe?ai?y oa
cieaeaiiy aene?aoe?? eaeueoe?th ia oaanue /an aenia?eiaioo. Iaeiae,
oo?eiaiiy eaeueoe?th a e?noeao, cieaeaia ia 7 aeiao, aei 14 aeiae
aeae?eueea ia?aaeuoaaei eiio?ieueia, a aei 30 aeiae ??cei c?inei
ia?aeaeueii ?c c?inoaiiyi eaeueoeeoii?io a ieaci? e?ia?. Oo?eiaiiy Na+ ?
K+ a e?noeao oaeiae c?inoaei aei 30 aeiae , ui iiaiaeeoueny c
aioeiao??eo?aoe/iith ae??th iao-aieaoae?io (Quito F. L., 1987). Oaea
??cieoey a ?iciiae?e? aeaeo?ie?o?a o iieiaeeo e aei?ineeo uo??a ca’ycaia
c ??ciith ?ieeth EO a iioiaaiac?.

Ia 7 aeiao aaaaeaiiy ?iaeiiaoaoeeio ie niinoa??aaee c?inoaiiy ??aiy
iao-aieaoae?io, ui aoa cia/iei o aei?ineeo uo??a, oa iaaeinoia??iei o
iieiaeeo. Ia 14 aeiao ??aaiue iao-aieaoae?io i?iaeiaaeoaaa c?inoaoe o
ii??aiyii? c eiio?ieai a iaio a?oiao. Oa ae oaiaeaioe?y niinoa??aaeany o
iieiaeeo oaa?ei ? ia 30 aeiao. C?inoaiiy ??aiy iao-aieaoae?io ca’ycaia c
i?eaiiaethaaiiyi neioaco IAA2 ?iaeiiaoaoeeiii e onoiaiiyi
i?eaiiaethth/iai aieeao IAA2 ia neioac oa nae?aoe?th aiaeiaaiieo
ii?i?ae?a. Iaeiae, o aei?ineeo uo??a aei 30 aeiae aenia?eiaioo ??aaiue
iao-aieaoae?io a ieaci? e?ia? cieceany o ii??aiyii? c eiio?ieai ? 14
aeiaith. O aei?ineeo oaa?ei ie niinoa??aaee c?inoaiiy ??aiy EO ia an?
no?iee aaaaeaiiy ?iaeiiaoaoeeio , oiaoi, eiee aieea IAA2 onoiaiee ca
aeiiiiiaith ?ia?a?oi?o oeeeeiieneaaiace — ?iaeiiaoaoeeio, ie iiaeaii
iaea?aeai? ci?ie c aieo eaeueoeeoii?io iiynieoe i?aeaeuaiei ??aiai
iao-aieaoae?io a ieaci?, ui i?aeoaa?aeaeothoue aeai? e?oa?aoo?e i?i
noeioethth/ee aieea iao-aieaoae?io ia nae?aoe?th EO (Neaiooeei A. Ae.,
Cieiaa A. E., 1988).

O iieiaeeo uo??a a?aecia/a?oueny cieaeaiiy ??aiy EO ia an? no?iee
aaaaeaiiy ?iaeiiaoaoeeio o ii??aiyii? c iaeiia?eiaei eiio?ieai, aea ia
30 aeiao eiai ??aaiue c??n o ii??aiyii? c 7 e 14 aeiaith. ??aaiue
eaeueoe?th, cieaeaiee ia 7 aeiao, ii?iae?co?oueny aei 30 aeiae
aenia?eiaioo, eiai aene?aoe?y oaeiae cieaeaia, ui ca’ycaia c ei?eaoth/ei
aieeaii IOA (Eea? N., 1987). Oo?eiaiiy Na++, Na+, E+ a e?noeao
ii?iae?co?oueny aei 30 aeiae aenia?eiaioo, ui ei?aeth? ?c c?inoaiiyi
??aiy EO a ieaci? e?ia? aei 30 aeiae aenia?eiaioo.

Neioaoe/i? aiaeiae aiaeiaaiieo ii?i?ae?a ciaioothoue ??aaiue IAA2 a
oea?aa?ini?iaeuei?e ??aeei? oa e?ia?, yea a?aeanue aeey aeine?aeaeaiiy
?c niiii? a?oa??? 211. IA a?oie A noeioeththoue neioac oeAIO a ee?oeao
a?iio?co, aea ii?o?e ciaioo? ??aaiue oeAIO 212, ui aeaco? ia aioaaii?ci
i?ae IAA2 e ii?i?aeaie ia ??ai? OeIN, ui i?aeoaa?aeaeo? ? iaoa
aeine?aeaeaiiy.

Ii-??ciiio ae?? aeciaaiiee IAA2 ia ??ai? eaeueoeeoii?io o iieiaeeo oa
aei?ineeo uo??a, ui i?aeoaa?aeaeo? aeoieo i?i ??ciiiai?oio ?ieue EO a
iioiaaiac?. ?iciiae?eaiiy aeaeo?ie?o?a o a?ieia?/ieo ??aeeiao o
??ciia?eiaeo oaa?ei aoei ??ciei, ui na?ae/eoue i?i ia?aaaaeaiiy
e?noeiaiai aoaeoo o iieiaeeo in?a oa ie?eiaiai aoaeoo o aei?ineeo.

?ieue aiaeiaaiieo ii?i?ae?a a ?aaoeyoi?ieo aca?iia?aeiineiao
a?iioaeaii-a?iio?ca?ii?, ?ai?i-aeueaeinoa?iiiai? nenoai oa
eaeueoeeoii?io a aaiac? e aeeaaiinoeoe? na/ieai’yii? oai?iae.

Iacaaaeath/e ia /anoioo caoai?thaaiino? o?ie?o?acii (iai?eeeaae, na?aae
aia?eeaioe?a — 1% a?ae caaaeueii? caoai?thaaiino?), iiooee
ao?iiaoiaaiaco i?iaiaeyoueny ia ??ai? o?ceei-o?i?/iiai neeaaeo eaiai?a.

Iaoith aeaiiai aeine?aeaeaiiy noaei aea/aiiy aeoeaiino? ?ai?io ieacie
(A?I), ??aiy ne?iaaoeiaiai aeueaeinoa?iio e aeoeaiino?
a?iioaeaii-a?iio?ca?ii? nenoaie o oai?eo na/ieai’yiith oai?iaith a
ii??aiyii? c ?ioith o?ieia?/iith iaoieia??th aeey oeeaaeaiiy
ae?aaiinoe/ieo e?eoa???a, ui oa?aeoa?ecothoue oa /e ?ioa caoai?thaaiiy
ie?ie ? ?ic?iaee eiina?aaoeaieo cania?a e?eoaaiiy NEO c iiceoe?e
ao?iiaoiaaiaco.

A ?acoeueoao? aeine?aeaeaiiy aeyaeeiny, ui A?I i?aeaeuo?oueny i?e an?o
caoai?thaaiiyo ie?ee, aeeeeeath/eo ?oai?th ie?eiai? ia?aio?ie, a naia
iie?e?noic?, iooeei? ie?ee, a?ae?iiao?ic?, a iaio?e i??? — eeno? ie?ee e
o?ie?o?ac? i?e caeaaeai? ioi/oth/eo oeaiei eiie?aiaioii, yeee i?noeoueny
a ie?eia?e ienoe?.

??aaiue aeueaeinoa?iio i?aeaeuoaaany i?e o?ie?o?ac? (iacaeaaeii a?ae
eieae?caoe?? eaiaith), ui iiaea aooe ca’ycaia c ii?ooaiiyi
aeaeo?ie?oiiai aaeaino (eae??aiai, cie?aia).

Oaaeeoey 2

Iieacieee ?ai?i-aeueaeinoa?iiiai? nenoaie o oai?eo

caoai?thaaiiyie ie?ie.

Ee?i?/i? a?oie A?I, ia/ie// Aeueaeinoa?ii, ia/ie

Eiio?ieue (n=162) 4,97 SYMBOL 177 \f «Symbol» \s 13 ± 0, 6 169, 3 SYMBOL
177 \f «Symbol» \s 13 ± 22,9

NEO, eai?iue ie?eiai? ienee (n=68) 6,1 SYMBOL 177 \f «Symbol» \s 13 ± 0,
2 208,6 SYMBOL 177 \f «Symbol» \s 14 ± 20, 4

NEO, eai?iue na/iaiaeo (n=22) 4,62 SYMBOL 177 \f «Symbol» \s 13 ± 0, 8
255,75 SYMBOL 177 \f «Symbol» \s 13 ± 18,4*

O?. i??eiiao?eo (n=20) 2,75 SYMBOL 177 \f «Symbol» \s 13 ± 0, 6* 184,8
SYMBOL 177 \f «Symbol» \s 13 ± 20,2

O?. i??eiiao?eo ?ae. ie?ee (n=18) 3,88 SYMBOL 177 \f «Symbol» \s 13 ± 0,
3 430,0 SYMBOL 177 \f «Symbol» \s 13 ± 24,3*

A?ae?iiao?ic (n=36) 7,1 SYMBOL 177 \f «Symbol» \s 13 ± 1, 1 106,0 SYMBOL
177 \f «Symbol» \s 13 ± 14,2

Iooeeia ie?ee (n=32) 8,68 SYMBOL 177 \f «Symbol» \s 13 ± 0,9* 93,3
SYMBOL 177 \f «Symbol» \s 13 ± 10,2*

Eenoa ie?ee (n=35) 6,05 SYMBOL 177 \f «Symbol» \s 13 ± 0,8 179,4 SYMBOL
177 \f «Symbol» \s 13 ± 20,6

Iie?e?noic ie?ie (n=68) 15,23 SYMBOL 177 \f «Symbol» \s 13 ± 1,4* 219,3
SYMBOL 177 \f «Symbol» \s 13 ± 16,8

*- p SYMBOL 163 \f «Symbol» \s 13 F 0.05 (o ii??aiyii? c
eiio?ieai).

Oaeei /eiii, ? o aeiaaeeo a?aeiieo ao?iiaoiaaiaoe/ieo iaoai?ci?a ci?ie
?ai?i-aeueaeinoa?iiiai? nenoaie i?e ii?acoe? ie?ie, oa i?e iaynieo, aea
ui iathoue i?noea, caeiiii??iinoyo (iiyniaiiy yeei aoaeooue
c’yniaoaaoeny i?e a?eueo aeaoaeueiiio iiaeaeueoiio aeine?aeaeaii?),
i?iaaaeaia aeine?aeaeaiiy aeanoue iiaeeea?noue aaea iei? canoiniaoaaoe
ia i?aeoeoe? anoaiiaeai? ae?aaiinoe/i? e?eoa??? o?ieia?/ii? iaoieia?? ia
iniia? ianoaaeaiiy ?ai?iaeueaeinoa?iiiaiai noaoono.

Eiioeaio?aoe?y iaoeii?i-aieaoae?io a ieaci? o an?o oai?eo
caoai?thaaiiyie ie?ie aoea cia/ii aeua, i?ae o caei?iaeo ethaeae.

Oaaeeoey 3

Iieacieee a?iioaeaii-a?iio?ca?ii? nenoaie o oai?eo ia

caoai?thaaiiy ie?ie.

Ee?i?/i? a?oie Iao-aieao.,

ia/ie AAeA, ia/ie AEOA, ia/ie I?ieaeo.,

Iae/ie

Eiio?ieue (n=162) 92,8 SYMBOL 177 \f «Symbol» \s 13 ± 18,6 4,0 SYMBOL
177 \f «Symbol» \s 13 ± 0,02 102,6 SYMBOL 177 \f «Symbol» \s 13 ± 3,6
92,8 SYMBOL 177 \f «Symbol» \s 13 ± 14,3

NEO, eai?iue ienee

(n=28) 394,2 SYMBOL 177 \f «Symbol» \s 13 ± 38,6* 3,1 SYMBOL 177 \f
«Symbol» \s 13 ± 0,07* 164,06 SYMBOL 177 \f «Symbol» \s 13 ± 16,1* 330,2
SYMBOL 177 \f «Symbol» \s 13 ± 18,5*

NEO, eai?iue na/ia.

(n=22) 599,9 SYMBOL 177 \f «Symbol» \s 13 ± 26,2* 2,95 SYMBOL 177 \f
«Symbol» \s 13 ± 0,02* 158,3 SYMBOL 177 \f «Symbol» \s 13 ± 15,6* 270,9
SYMBOL 177 \f «Symbol» \s 13 ± 24,5*

O?. I??eiiao?eo

(n=20) 183,7 SYMBOL 177 \f «Symbol» \s 13 ± 16,6* 4,17 SYMBOL 177 \f
«Symbol» \s 13 ± 0,08* 283,0 SYMBOL 177 \f «Symbol» \s 13 ± 20,0* 329,0
SYMBOL 177 \f «Symbol» \s 13 ± 31,4*

O?.i??eii.?ae. ie?ee

(n=18) — 4,27 SYMBOL 177 \f «Symbol» \s 13 ± 0,2 21,0 SYMBOL 177 \f
«Symbol» \s 13 ± 4,2* 117,5 SYMBOL 177 \f «Symbol» \s 13 ± 16,8

Eenoa ie?ee (n=35) 600,0 SYMBOL 177 \f «Symbol» \s 13 ± 34,7* 4,02
SYMBOL 177 \f «Symbol» \s 13 ± 0,09 197,5 SYMBOL 177 \f «Symbol» \s 13 ±
14,2* —

Iie?eenoic ie?ie

(n=68) 1871,0 SYMBOL 177 \f «Symbol» \s 13 ± 52,6* 3,92 SYMBOL 177 \f
«Symbol» \s 13 ± 0,03* 58,4 SYMBOL 177 \f «Symbol» \s 13 ± 6,3* —

*-p SYMBOL 163 \f «Symbol» \s 13 F 0.05 (o ii??aiyii? c eiio?ieai).

Iaeiae nooi?iue i?aeaeuaiiy eiai ieaciiaiai ??aiy ??cei a?ae??ciy?oueny
a ??cieo ee?i?/ieo a?oiao. sseui o oai?eo o?ii?/iei i??eiiao?eoii eiai
oo?eiaiiy ca?eueoo?oueny aaea?/?, oi o oai?eo na/ieai’yiith oai?iaith ?
c eaiaiai a ie?eia?e ienoe?, ? a na/iaiae? — a 3-4 ?ace, a o oai?eo
eenoaie ie?ie — a 6-20 ?ac! (oaae. 3).

??cieoeth ai?noo iaoeii?i-aieaoae?io e aeueaeinoa?iio o oai?eo
o?ie?o?acii c eieae?caoe??th eaiaith a ie?eia?e ienoe? e na/iaiae?
(a?eueoa ?oiy eiioeaio?aoe?y o inoaii?o), iiaeia ca’ycaoe c
o?aiceoi?ieie a?ae?iiao?ioe/ieie ci?iaie ,ui ? o oai?eo c eaiaiai a
na/iaiae?.

A ?aaoeyoe?? aiiioico cia/io ?ieue a?ae?a?a? nenoaia aiaeiaaiieo
ii?i?ae?a. Aaii?noe ith- oa eaiia-ii?i?aeieo ?aoeaioi??a aeeeeeathoue
aiiioic a iae?iiieo eoeueoo?ao aieiaiiai iiceo eo?/ao. A ?acoeueoao?
aeine?aeaeaiiy anoaiiaeaii, ui ii?i?aeia noeioeyoe?y aiiioico caniiaaia
ia i?eaiiaeaii? aeoeaiino? aaeai?eaooeeeeace (Goswami R., Dawson S.A.,
1998). Ii?o?e iiaeoeth? ooieoe?th ?ioiii? nenoaie, noeioethth/e aiiioic
nieaiioeeo?a (Singhal P.C., Sharma P., 1998). Aoi?o?i, aaii?no
ii?i?aeieo ?aoeaioi??a, oiia?eueiya ??no ee?oei ? noeioethaaa aiiioic
(Yin D.L., Ren X.H., 1997). Oaeei /eiii, o iaoiio aeine?aeaeaii? o
oai?eo ia na/ieai’yio oai?iao, a 4-6 ?ac?a i?aeaeuaia aeoeai?noue
nenoaie, yea noeioeth? aiiioic. E??i oiai, nenoaie IA oa aiaeiaaiieo
ii?i?ae?a ?aaoeththoue i?ioeane aec??aaiiy ee?oei oa ?o o?c?ieia?/ii?
caaeaae? ca?eueooth/e aai ciaiooth/e oeAIO. A oie iiiaio, eiee oe? aea?
nenoaie aaea ia ni?iiiaei? aooe a ??aiiaac?, a neioac ii?i?ae?a
inoaoi/ii aeoiaeeoue c-i?ae eiio?ieth, ?icaeaathoueny oneeaaeiaiiy
na/ieai’yii? oai?iae.

??aaiue aacii?aneio ci?ithaaany eeoa o oai?eo o?ie?o?acii c
eieae?caoe??th eaiaith a na/iaiae? , ui a ii?aeiaii? c i?aeaeuaiei
??aiai iao-aieaoae?io ? aeueaeinoa?iio iiaea ?icaeyaeaoeny ye
eiiiainaoi?iee iaoai?ci, iai?aaeaiee i?ioe ie?eiai? a?ae?iiao?ioe/ii?
o?ainoi?iaoe??, aeeeeeaiith iano?oeoe??th na/iaiaeo eaiaiai ?
ca?eueoaiiyi iicaee?oeiiiai ia’?io ??aeeie, yeiio ni?ey? cao?eiea
iniioe/ii aeoeaieo aeaeo?ie?o?a a i?aai?ci?.

Ie aea/eee ??aaiue eaeueoeeoii?io o oai?eo na/ieai’yiith oai?iaith, o
caei?iaeo aeiii??a — aeeoae?a Eoaainueei? iaeano? a c?noaaeaii? c?
na?aaeiueinoaoenoe/iith ii?iith aeeoae?a ?ioeo ?aa?ii?a.

??aaiue eaeueoeeoii?io o caei?iaeo aeiii??a — aeeoae?a Eoaainueei?
iaeano?, iaeaea o 2 ?ace ieae/a na?aaeiueinoaoenoe/ii? ii?ie
eaeueoeeoii?io ?ioeo ?aa?ii?a. A o oai?eo o?ie?o?acii – o 2 ?ace ieae/a,
i?ae a eiio?ie?.

Ee?i?/i? aeine?aeaeaiiy oai?eo ia NEO aeaee iai iiaeeea?noue aeoiaoe, ui
aieiaieie eaioethaaie iaoiaaiaco o?ie?o?aco ? ii?ooaiiy nae?aoe??
eaeueoeeoii?io e aiaeiaaiieo ii?i?ae?a, caaaeyee /iio ii?ooo?oueny
aeaeo?ie?oiee aaeain, ?, a ia?oo /a?ao eaeueoe??aee aiiainoac. A na?o?
inoaii?o aeine?aeaeaiue ?ie? eaeueoe?th a iaoiaaiac? aaaaoueio
caoai?thaaiue iaaea?oueny aaeeea oaaaa.

Ae??oaeueio iaoiaaiaoe/io ?ieue a ?icaeoeo o?ie?o?aco, ia iaoo aeoieo,
a?ae?a?a? ??cea cieaeaiiy aacaeueiiai ??aiy eaeueoeeoii?io ia oii?
i?aeaeuaii? aeoeaiino? aiaei?o?i -, aieaoae?ia?ae/ii? nenoaie c
aoyaiaiiyi ?ai?i-aeueaeinoa?iiiai? nenoaie.

A ca’yceo c oeei aeniea caoai?thaai?noue na/ieai’yiith oai?iaith
aeeoae?a Eoaainueei? iaeano? aeaoa?i?iiaaia iecueeith ai?iiiaeueiith
aeoeai?noth eaeueoeeoii?io a iiioeyoe??.

ssI?-?aeaenaoe?y i?ioii?a oeaieiii? aiaee a?ieia?/ieo ??aeei a
aeeoa?aioe?ei?e aeeaaiinoeoe? na/ieai’yii? oai?iae.

Ne?aeoth/ei aoaiii iaoiai aeine?aeaeaiiy noaei aea/aiiy
ssI?-?aeaenaoe?eieo oa?aeoa?enoee a?ieia?/ieo ??aeeie o oai?eo
na/ieai’yiith oai?iaith.

A?oie, ui aeine?aeaeoaaeeny aeeth/aee oai?eo c eaiaiai na/iaiai i?oo?a,
eieae?caoe??th eaiaith a na/iaiae?, eieae?caoe??th eaiaith a ie?eia?e
ienoe?; aeainoi?iiiueith NEO; NEO ?aeeii? ie?ee. Oai?? o?ii?/iei
i??eiiao?eoii e iie?eenoicii ?icaeyaeaeeny, ye a?oie ii??aiyiiy.

a- eiio?ieueia a?oia a- oai??

1- NEO, eai?iue na/iaiai i?oo?a 5- NEO ?aeeii? ie?ee

2- NEO, eai?iue na/iaiaeo 6- o?ii?/iee i??eiiao?eo

3- NEO, eai?iue ie?eiai? ienee 7- iie?eenoic ie?ie

4- 2noi??iiy NEO

?en. 1 ssI? — ?aeaenaoe?y (iiacaeiaaeiy, O1) i?ioii?a oeaieiii?
aiaee ne?iaaoee e?ia? oai?eo ia ie?eia? caoai?thaaiiy.

A e?ia? /an iiacaeiaaeiuei? ?aeaenaoe?? O1 o oai?eo NEO c eieae?caoe??th
eaiaith a na/iaiae?, 2-o noi?iiiuei? NEO, NEO ?aeeii? ie?ee e o?ii?/iei
i??eiiao?eoii cieaeoaaany, oaeiae, ye ? /an iiia?a/ii? ?aeaenaoe?? O2,
ui oa?aeoa?eco? iiyao a?ae?iaaiiai oa?o oeaieiii? aiaee. O oai?eo c
eieae?caoe??th eaiaith a ie?eia?e ienoe? e iie?e?noic? ie?ee iieaciee
iiacaeiaaeiuei? ?aeaenaoe?? i?ioii?a oeaieiii? aiaee e?ia? O1
iiaeiaaeo?oueny, oiae? ye /an iiia?a/ii? ?aeaenaoe?? nei?i/o?oueny, oi/a
? ia oae cia/ii, ye a cacia/aieo aeua a?oiao ui aeaco? ia oi?ioaaiiy
e?enoaeueiaaiii? o?aeoe?? aiaee.

O oai?eo NEO (eai?iue a ie?eia?e ienoe? ) oa iie?eenoicii ie?ie /ane
iiacaeiaaeiuei? e iiia?a/ii? ?aeaenaoe?? i?ioii?a aiaee ne?iaaoee cia/ii
iaio?, i?ae a eiio?ieuei?e a?oi?. Cieaeaiiy iao??th ia oii? iaci?iiiai
??aiy eae?th o oeeo oai?eo, aeanoue iiaeeea?noue ?iiai eae?th
?icii?yaeeoaaoe no?oeoo?o aiaee c oi?ioaaiiyi iaaeiei naaa a?ae?iaaiiai
oa?o, ia ui aeacothoue iieacieee ssI?-?aeaenaoe?? i?ioii?a oeaieiii?
aiaee.

A- eiio?ieueia a?oia a- oai??

1- NEO, eai?iue na/iaiai i?oo?a 5- NEO ?aeeii? ie?ee

2- NEO, eai?iue na/iaiaeo 6- o?ii?/iee i??eiiao?eo

3- NEO, eai?iue ie?eiai? ienee 7- iie?eenoic ie?ie

4- 2-noi??iiy NEO

?en. 2 ssI? — ?aeaenaoe?y (iiacaeiaaeiy, O2) i?ioii?a oeaieiii?
aiaee ne?iaaoee e?ia? oai?eo ia ie?eia? caoai?thaaiiy.

Oaea ae ea?oeia ?aeaenaoe?eiii? aeoeaiino? a ne?iaaooe? e?ia?
niinoa??aaeany ? o oai?eo NEO c eieae?caoe??th eaiaith a na/iaiae?, e c
2-o noi?iiiueith NEO, e c NEO ?aeeii? ie?ee, ui oe?eeii ni?aiaaea? c
iieacieeaie iao??th (cieaeaiiy) ? eae?th (ii?ia) o oeeo oai?eo.

*an iiacaeiaaeiuei? ?aeaenaoe?? ne?iaaoee e?ia? O1 oai?eo ia o?ii?/iee
i??eiiao?eo ca?eueooaaany, oiae? ye /an iiia?a/ii? ?aeaenaoe?? O2
nei?i/oaaany, oiaoi ? oa?aeoa?enoeea e?enoaeueiaaii? o?aeoe?? oeaieiii?
aiaee. ? oea ia iai?i/oae, ai c an?o caoai?thaaiue ,ui
aeine?aeaeoaaeeny, oea ?aeeia iicieia?y, ui oa?aeoa?eco?oueny
ii?iaeueiei ai?noii a ne?iaaooe? e?ia? iao??th, ia oii? a?iieae?ai??.
Oaeei /eiii, iao??e, ye iiceoeaii a?ae?aooth/ee ?ii, oiia?eueith? iai?i
iaeaeeae/eo aei iueiai iieaeoe aiaee, ui coiiaeth? o?eaea ca’ycoaaiiy
oeaieiii? aiaee a e?enoaeueiaaio o?aeoe?th.

Ia?aiao? O1 caeaaeeoue a?ae aeaio oaeoi??a: ai?noo an??? oeaieiii? aiaee
e ni?iiiaeiino? iae?iiieaeoe a?ee?a oa iie?naoa?eae?a ca’ycoaaoe aiaeo a
a?ae?iaaiee oa?. A oie aea /an O2 caeaaeeoue a?ae e?eueeino? ae?eyiie,
ye? ca’ycothoue aiaeo a e?enoaeueiaaiee oa? oa a?ae oiaueie
a?ae?iaaiiai oa?o.

O oai?eo NEO c eieae?caoe??th eaiaith a na/iaiae? ? ie?eia?e ienoe?,
iiacaeiaaeiy e iiia?a/ia ?aeaenaoe?y i?ioii?a oeaieiii? aiaee na/?
nei?i/ai?, ui aeaco? ia iayai?noue a?ae?iaaiiai oa?o oeaieiii? aiaee,
oi/a aene?aoe?y iao??th e eae?th o oeeo oai?eo cieaeaia .

2-o noi?iiiy NEO oa?aeoa?eco?oueny cieaeaiiyi iiacaeiaaeiuei?
?aeaenaoe?? O1 ia oii? i?enei?aii? iiia?a/ii? — O 2. Oaea ii?aeiaiiy
ssI?-iieaciee?a ?aeaenaoe?? oeaieiii? aiaee aiai?eoue i?i iayai?noue a
na/? e?i?ae?a, aai e?i?aei — iiae?aieo niieoe, nei??oa onueiai
i?inoaii?ae?a, ui iiaiaeeoueny c iaoeie aeine?aeaeaiiyie.

NEO ?aeeii? ie?ee oa?aeoa?ecoaaeiny cieaeaiiyi iiia?a/ii? ?aeaenaoe??
i?ioii?a oeaieiii? aiaee O 2 na/?, i?e iaci?ii? iiacaeiaaei?e — O1.
Iieaciee iiia?a/ii? ?aeaenaoe??, i?e oeueiio, a?aeia?aaea?
eiioeaio?aoe?th i?noeue ca’ycoaaiiy ? oiaueio a?ae?iaaiiai oa?o.

Iieacieee ssI?-?aeaeniiao??? a c?noaaeaiiyi c aeaeo?ie?oiei neeaaeii
ne?iaaoee e?ia? i?aeoaa?aeaeothoue, ui iniiaiei iaoiaaiaoe/iei
eaioethaii a ?icaeoeo NEO ? ii?ooaiiy aeaeo?ie?oiiai iai?io.

Aaoi?e, ye? aea/aee no?oeoo?o oeaieiii? aiaee (Fullerton G. D., 1982;
Ling G. N., 1988; Cameron I. L., 1988) aeacothoue ia ca?eueoaiiy
a’yceino? a?ae?iaaiii? aiaee e cieaeaiiy ?ic/eiiino? a i?e ?ii?a. Oaeei
/eiii, ia o?eueee ca?eueoaiiy aene?aoe?? eaeueoe?th e ia?aiane/aiiy oeei
?iiii na/?, a ? no?oeoo?a naii? oeaieiii? aiaee na/? i?ecaiaeeoue aei
cieaeaiiy ?ic/eiiino? nieae eaeueoe?th e ooai?aiith eiie?aiaio?a.

Oaae. 4

??aaiue aeaeo?ie?o?a iao??th oa eae?th a ne?iaaooe? e?ia? e na/? o
oai?eo ia

ie?eia? caoai?thaaiiy.

ne?iaaoea na/a

iao??e eae?e iao??e eae?e

Eiio?ieue 140,2 SYMBOL 177 \f «Symbol» \s 14 ± 2,4 4,5 SYMBOL 177 \f
«Symbol» \s 14 ± 0,3 140,0 SYMBOL 177 \f «Symbol» \s 14 ± 10,4 58,0
SYMBOL 177 \f «Symbol» \s 14 ± 6,2

Eai?iue na/iaiai i?oo?a 119,0 SYMBOL 177 \f «Symbol» \s 14 ± 2,1 SYMBOL
42 \f «Symbol» \s 14 * 3,9 SYMBOL 177 \f «Symbol» \s 14 ± 0,2 SYMBOL
42 \f «Symbol» \s 14 * 100,5 SYMBOL 177 \f «Symbol» \s 14 ± 10,2 SYMBOL
42 \f «Symbol» \s 14 * 77,0 SYMBOL 177 \f «Symbol» \s 14 ± 9,3 SYMBOL
42 \f «Symbol» \s 14 *

Eai?iue na/iaiaeo 127,8 SYMBOL 177 \f «Symbol» \s 14 ± 7,6 SYMBOL 42 \f
«Symbol» \s 14 * 4,36 SYMBOL 177 \f «Symbol» \s 14 ± 0,4 103,0 SYMBOL
177 \f «Symbol» \s 14 ± 7,9 SYMBOL 42 \f «Symbol» \s 14 * 48,7 SYMBOL
177 \f «Symbol» \s 14 ± 6,9 SYMBOL 42 \f «Symbol» \s 14 *

Eai?iue ie?eiai? ienee 117,3 SYMBOL 177 \f «Symbol» \s 14 ± 7,5 SYMBOL
42 \f «Symbol» \s 14 * 4,7 SYMBOL 177 \f «Symbol» \s 14 ± 0,5 SYMBOL 42
\f «Symbol» \s 14 * 91,4 SYMBOL 177 \f «Symbol» \s 14 ± 9,2 SYMBOL 42
\f «Symbol» \s 14 * 30,0 SYMBOL 177 \f «Symbol» \s 14 ± 6,5 SYMBOL 42
\f «Symbol» \s 14 *

2-noi??iiy NEO 115,0 SYMBOL 177 \f «Symbol» \s 14 ± 8,9 SYMBOL 42 \f
«Symbol» \s 14 * 5,8 SYMBOL 177 \f «Symbol» \s 14 ± 0,7 SYMBOL 42 \f
«Symbol» \s 14 * 93,0 SYMBOL 177 \f «Symbol» \s 14 ± 8,7 SYMBOL 42 \f
«Symbol» \s 14 * 50,0 SYMBOL 177 \f «Symbol» \s 14 ± 6,4 SYMBOL 42 \f
«Symbol» \s 14 *

NEO ?aeeii? ie?ee 114,0 SYMBOL 177 \f «Symbol» \s 14 ± 13,5 SYMBOL 42 \f
«Symbol» \s 14 * 10,6 SYMBOL 177 \f «Symbol» \s 14 ± 1,2 SYMBOL 42 \f
«Symbol» \s 14 * — —

O?. i?aeiiao?eo 138,0 SYMBOL 177 \f «Symbol» \s 14 ± 9,8 3,2 SYMBOL 177
\f «Symbol» \s 14 ± 0,3 SYMBOL 42 \f «Symbol» \s 14 * — —

Iie?eenoic ie?ie 119,0 SYMBOL 177 \f «Symbol» \s 14 ± 8,7 SYMBOL 42 \f
«Symbol» \s 14 * 4,5 SYMBOL 177 \f «Symbol» \s 14 ± 0,4 56,0 SYMBOL 177
\f «Symbol» \s 14 ± 6,4 SYMBOL 42 \f «Symbol» \s 14 * 58,0 SYMBOL 177
\f «Symbol» \s 14 ± 5,9

? SYMBOL 163 \f «Symbol» \s 14 F 0,05 o ii??aiyii? c eiio?ieai

Oaeei /eiii, ssI?-iieacieee i?ioii?a oeaieiii? aiaee e?ia?, ne?iaaoee
e?ia? oa na/? i?e ??cieo oi?iao NEO e ?io?e ie?eia?e iaoieia??
niaoeeo?/i?, ei?aeththoue e a?aeia?aaeathoue aeeiai?eo iaoiaaiaoe/ieo
iae?iai?iiiaeueieo iaoai?ci?a ? noaio aiiainoaoe/ieo ooieoe?e i?aai?cio.

AENIIAEE.

Anoaiiaeaia iioiaaiaoe/ia aeeiai?ea ??aiy iaoeii?i-aieaoae?io oa
eaeueoeeoii?io a aenia?eiaio?, a naia, iaeneiaeueiee ieaciiaee ai?no a
4-oeaeiaaiio a?eo iaoeii?i-aieaoae?io ii i??? c?inoaiiy oaa?ei
cieaeoaaany o 2 ?ace, a eaeueoeeoii?io — a 2,5 ?ace.

Aeciaaiia aaaaeaiiy IAA2 (aeoeaaoi?o inoaieeano?a) o aei?ineeo oaa?ei
aeeeeeaa ?icaeoie a?ia?eaeueoe?ai?? /a?ac cieaeaiiy ??aith eaeueoe?th a
e?noeia?e oeaiei?, /iio ia?aoeiaeaeaea eiiiainaoi?ia a?ia?eaeueoe?o??y,
aeeeeeaia ca?eueoaiiyi nae?aoe?? eaeueoeeoii?io.

I?inoaaaeaiaeeie ? aioaaii?noaie ii?i?ae?a ii iaoai?cio ae?? oa ii
iaiaaeaiith ?oiuei? nae?aoe??. Aeciaaiiee IAA2 aiiaea ??aaiue
aieaoae?ia?a?/ii? aeoeaiino? ye o iieiaeeo, oae ? o aei?ineeo oaa?ei, oa
aeac?ioaa?oaaa eaeueoe?e — oa iao??e?aaoeyoi?i? iaoai?cie a a?eueoiio
nooiai? o iieiaeeo oaa?ei, ui iiaeaeth? ia 7 aeiao aaaaeaiiy ea?oeio
«i?enei?aiiai» iioiaaiaco (ciaioaiiy ieaciiaiai ??aith
iaoeii?i-aieaoae?io e eaeueoeeoii?io; cieaeaiiy aene?aoe?? eaeueoe?th c
na/ath).

C?inoaiiy aei 14 — 30 aeiae ??aiy iaoeii?i-aieaoae?io o iieiaeeo oaa?ei
ii iaoai?cio cai?ioiiai ca’yceo ?, a?aeiia?aeii ??aiy eaeueoeeoii?io,
yeee c?inoaa i?ae ae??th a?ia?eaeueoeeai??, aeeeeeaa ca?eueoaiiy
oo?eiaiiy eaeueoe?th a e?noeao ia oii? eaeueoe?eo???.

Aaaaeaiiy ?iaeiiaoaoeeio ? o iieiaeeo, ? o aei?ineeo oaa?ei iaei
a?aeaeeiny ia ??ai? eaeueoe?th a ne?iaaooe? e?ia?, iaeiae iaoai?cie
caaacia/aiiy oaei? aiiainoaoe/ii? noaa?eueiino? oe?eeii i?ioeeaaei?: o
iieiaeeo oaa?ei — cieaeaiiy aene?aoe?? eaeueoe?th, i?aeaeuaiiy eiai
oo?eiaiiy a e?noeao, cieaeaiiy ??aiy eaeueoeeoii?io, i?aeaeuaiiy ??aiy
iaoeii?i-aieaoae?io; oiae? ye o aei?ineeo oaa?ei — i?enooiy cai?ioia
aeeiai?ea icia/aieo iieaciee?a.

Ee?i?/iei i?iyaii ii?ooaiiy eaeueoe??aiai aiiainoaco, ? na/ieai’yia
oai?iaa, iae?iai?iiiaeueiee iaoiaaiac yei?, ye iieacaee iao?
aeine?aeaeaiiy, neeaaea?oueny c aeoeaaoe?? aieaoae?ia?a?/iiai
?aaoethaaiiy ?ai?i-aeueaeinoa?iiiai? nenoaie ia oii? ??ceiai i?eai?/aiiy
i?iaeoeoe?? eaeueoeeoii?io.

ssI?-iieacieee i?ioii?a oeaieiii? aiaee e?ia? e na/? i?e caoai?thaaiiyo
ie?ie aeniei niaoeeo?/i?, ei?aeththoue ? a?aeaeca?eaeththoue aeeiai?eo
iaoiaaiaoe/ieo iae?iai?iiiaeueieo iaoai?ci?a oa noaio aiiainoaoe/ieo
ooieoe?e i?aai?cio, ui aeicaiey? aeei?enoaoe ?o o aeeoa?aioe?aeuei?e
ae?aaiinoeoe? aeaieo caoai?thaaiue i?e ne?ei?ia-oanooaaii?.

NIENIE I?AOeUe, UI IIOAE?EIAAI? CA OAIITH AeENA?OAOe??.

A. Iaianaiei «Aieea aeciaaiiiai IAA2 oa ?iaeiiaoaoeeio ia ieaciaiiee
??aaiue iao-aieaoae?io e eaeueoeeoii?io» \ Oe?a?inueeee iaaee/iee
aeueiaiao, 1999, ? 1, o. 2, n.87-91.

Nai/ee A. I., Iaianaiei I. A., Eiia?aaoeaaa E. A. «?ieue ia?aa?aaa,
iiiieneaea oaea?iaea e i?inoaaeaiaeeia A2 a iiin?aaeiaaiee aiiioica e eo
aeeyiea ia no?anni?ii-aaeaioaoeeiiioth nenoaio iao-yieaoaeei – AEOA i?e
yenia?eiaioaeueiii eiaeooee?iaaiee i?ia?aiie?oaiie eeaoi/iie aeaaee» \
I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??, 1998,
? 3, n.260-270.

E. A. Eiia?aaoeaaa, A. A. ?iuoieei, A. I. Eiia?aaoeaa, I. A. Iaianaiei,
A. I. Nai/ee «Eciaiaiea iaoaaieecia i?inoaiieaeia i?e eenoiciii
ii?aaeaiee ii/ae» \ Oe?aeineee aeioeie/aneee aeo?iae, 1997, ? 5-6 , o.
69, n. 168-176.

E. A. Eiia?aaoeaaa, A. I. Eiia?aaoeaa, I. A. Aa?iee, I. A. Iaianaiei, A.
A. ?iuoieei, A. A. Na?aaeaiei «?ieue aeiioaeaii-aeiioeca?ii-aae?aiaeiaie
nenoaiu a iaoiaaiaca aoi?e/iie aeia?oaicee ii/a/iiai aaiaca» \
Oe?a?inueeee ea?ae?ieia?/iee aeo?iae, 1997, ? 2, n. 30-35.

A. ?. I?i?i?i, ?. I. Eiia?aaoeaaa, I. A. Iaianaiei, A. I. Eiia?aaoeaa,
N. A. I?iai?i «ssI?-?aeaeniiao??y a?ieia?/ieo na?aaeiaeu o aeeaaiinoeoe?
caoai?thaaiue ie?ie»\O?ieia?y, ? 2, o. 3, n. 30-36.

I. A. Iaianaiei «Aieea aeciaaiiiai i?inoaaeaiaeeio A2 ia iai?i
eaeueoeeoii?io» \ O?c?ieia?/iee aeo?iae, 1998, ?3, o. 44, n.10.

M. Panasenko, A. Semenenko, M. Bondarenko «Urine NMR-relaxation
parameters, sodium and potassium ions excretion in ontogenesis.» 4th
International Medical Students Congress», Nov. 5-8, 1998, Katowice,
Poland.

Iaianaiei I. A. Iniaeeaino? aca?iia?aeiinei eaeueoeeoii?io oa
aiaeiaaiieo ii?i?ae?a i?e na/ieai’yi?e oai?ia?. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 03.00.04 – a?io?i?y.- ?inoeooo aa?iioieia??
Aeaaeai?? iaaee/ieo Iaoe, Ee?a, 1999.

A ?iaio?, ui ? aenia?eiaioaeueii-ee?i?/iith ?icaeyaeathoueny ieoaiiy
iaoiaaiaco na/ieai’yii? oai?iae, ye ii?ooaiiy iai?iieo i?ioean?a oa
aiaeii-nieueiaiai aaeaino, o ii??aiyii? c ?ioith iaoieia??th ie?ie.
Aea/ai? ii?ooaiiy ai?iiiaeueiiai niaeo?o aoee iaie iiaeoeueiaai? a
aenia?eiaio?, yeee ?icaeyaeaany ye iiaeaeue ii?ooaiiy iai?io eaeueoe?th.
E??i oiai, iaie aoa aeei?enoaiee iiaee iaoiae aeeaaiinoeee ii?ooaiue
aiaeii-aeaeo?ie?oiiai aaeaino i?e iaoieia?? ie?ie – ssI?-niaeo?ineii?y.
Aiae?c ?acoeueoao?a i?iaaaeaieo aeine?aeaeaiue aeicaiey? c?iaeoe
aeniiaee, ui iaoiaaiac NEO iia’ycaiee c ii?ooaiiyi noaio nenoaie
aiaeiaaiieo ii?i?ae?a (i?aeaeuaiiy ??aiy iao-aieaoae?io a ieaci? e?ia?)
oa cia/ia i?eaiiaeaiiy ??aiy eaeueoeeoii?io ia oii? i?eai?/aiiai aaea
??aiy oeueiai ai?iiio o caei?iaeo aeeoae?a «eai’yiiai iano». Ii?ooaiiy
aiaeii-nieueiaiai aaeaino ? iane?aeeii ii?ooaiue ai?iiiaeueiiai niaeo?o.
Aea/aiiy ssI?-niaeo?ineii?? aeicaiey? aeei?enoiaoaaoe aeaio iaoiaeeeo
aeey aeeoa?aioe?eii? aeeaaiinoeee iaoieia?? ie?ie. Aenia?eiaioaeueia
/anoeia ?iaioe aeicaiey? c?iaeoe aeniiaie, ui ii?ooaiiy a noai?
aiaeiaaiieo ii?i?ae?a, eaeueoeeoii?io oa i?inoaii?ae?a iia’ycai? i?ae
niaith, a?ae??ciythoueny caeaaeii a?ae a?eo oa ? i?e/eiith aeaeo?ie?oieo
ii?ooaiue.

Eeth/ia? neiaa: eaeueoeeoii?i, aiaeiaaii? ii?i?aee, ie?ee, na/ieai’yia
oai?iaa, yaea?ii-iaai?oiee ?aciiain.

Iaianaiei I. A. Iniaaiiinoe acaeiiioiioaiey eaeueoeeoiieia e yiaeiaaiiuo
iieieaeia i?e ii/aeaiaiiie aieacie.- ?oeiienue. Aeenna?oaoeey ia
nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii
niaoeeaeueiinoe 03.00.04 – aeioeiey.- Einoeooo aa?iioieiaee Aeaaeaiee
iaaeeoeeineeo Iaoe, Eeaa, 1999.

?aaioa yaeyaony eeeieei-yenia?eiaioaeueiie. A eeeie/aneie /anoe ?aaiou
iaie auee ianeaaeiaaiu aieueiua n iaoieiaeae ii/ae, iaoiaeyueany ia
ea/aiee a o?ieiae/aneii ioaeaeaiee Eoaaineie iaeanoiie eeeie/aneie
aieueieoeu. Auee enneaaeiaaiu o?iaie ai?iiiia – iaoeiiei-yieaoaeeia,
aioeaeeo?aoe/aneiai ai?iiia, aae?aiiei?oeeio?iiiiai ai?iiia, i?ieaeoeia,
aeueaeinoa?iia, aeoeaiinoue ?aieia ieaciu ?aaeeieiioiiui iaoiaeii. E?iia
oiai o aeaiiuo aieueiuo ii?aaeaeyeenue ia?aiao?u ssI?-?aeaenaoeee
i?ioiiia aiaei?iaea aeieiae/aneeo aeeaeeinoae niiiiuueth
ssI?-?aeaeniiao?a minispec 120 pc oe?iu «Brucer» e niaea?aeaiea eiiia
eaeey e iao?ey a nuai?ioea e?iae e ii/a c iiiiuueth
aeeaeeiee?iaiaeecaoi?a. O aieueiuo ii/aeaiaiiie aieaciueth iu
ii?aaeaeyee o?iaaiue eaeueoeeoiieia a n?aaiaiee ni caei?iauie aeiii?aie
– aeeoaeyie Eoaaineie iaeanoe, yaeythuaeny yiaeaie/iie ii IEA e
n?aaeianoaoenoe/aneie ii?iie. A yenia?eiaioaeueiie /anoe ?aaiou
eaai?aoi?iui e?unai eeiee Aenoa? ?aciiai aic?anoa aaiaeeeny
i?inoaaeaiaeei A2 a oa/aiea 7, 14 e 30 nooie. Caoai ii?aaeaeyeenue
o?iaie iaoeiiei-yieaoaeeia e eaeueoeeoiieia ?aaeeieiioiiui iaoiaeii, a
oaeaea niaea?aeaiea eaeueoeey niaeo?ioioiiao?e/anee, iao?ey, eaeey n
iiiiuueth aeeaeeiee?iaiaeecaoi?a a nuai?ioea e?iae, ii/a, einoyo.

Aiaeec iieo/aiiuo ?acoeueoaoia iicaieee naeaeaoue neaaeothuea auaiaeu.
Iaeneiaeueiia ieaciaiiia niaea?aeaiea a 4-iaaeaeueiii aic?anoa
iaoeiiei-yieaoaeeia ii ia?a ?inoa aeeaioiiai nieaeaeinue a 2 ?aca, a
eaeueoeeoiieia — a 2,5 ?aca. Aunieee o?iaaiue eaeueoeeoiieia e
noeioee?othuaai aai aeoeaiinoue iaoeiiei-yieaoaeeia o iieiaeuo
aeeaioiuo, oaaee/eaay ii/a/ioth yene?aoeeth eaeueoeey, iaania/eaatho
aiiainoaoe/anee noaaeeueiue o?iaaiue eaeueoeey a nuai?ioea e?iae,
eioi?ue caaeaenoaiaai a yoii aic?anoa a ?aaoeyoeee aaeaina
aeeooa?aioee?iaee e i?ieeoa?aoeee oeaiae. Yeciaaiiia aaaaeaiea IAA2
(aeoeaaoi?a inoaieeanoia) o ac?ineuo aeeaioiuo aucuaaei ?acaeoea
aeia?eaeueoeeaiee /a?ac nieaeaiea o?iaiy eaeueoeey a einoiie oeaie, /aio
i?aiyonoaiaaea eiiiainaoi?iay aeia?eaeueoeeo?ey, aucaaiiay oaaee/aieai
nae?aoeee eaeueoeeoiieia.

I?inoaaaeaiaeeiu yaeythony aioaaiienoaie iieieaeia ii iaoaiecio
aeaenoaey e ii ia?aie/aieth eo nae?aoeee. Yeciaaiiue IAA2 oaiaoae
o?iaaiue yieaoaeeiy?ae/aneie aeoeaiinoe eae o iieiaeuo, oae e o ac?ineuo
aeeaioiuo, aeaceioaa?e?oy eaeueoeee- e iao?ee?aaoeyoi?iua iaoaieciu a
aieueoae noaiaie o iieiaeuo aeeaioiuo, iiaeaee?oy ia 7 nooee aaaaeaiey
ea?oeio «onei?aiiiai» iioiaaiaca (oiaiueoaiea ieaciaiiiai o?iaiy
iaoeiiei-yieaoaeeia e eaeueoeeoiieia; nieaeaiea yene?aoeee eaeueoeey n
ii/ie).

?ino e 14 — 30 nooeai o?iaiy iaoeiiei-yieaoaeeia o iieiaeuo aeeaioiuo ii
iaoaiecio ia?aoiie nayce e, noeioee?iaaiiue ei niioaaonoaaiii o?iaaiue
eaeueoeeoiieia, onoaoaeee aeiieaeueoeeaieth, aucaaa oaaee/aiea
niaea?aeaiey eaeueoeey a einoyo ia oiia i?iaeieaeathuaeny eaeueoeeo?ee.

Aaaaeaiea eiaeiiaoaoeeia e o iieiaeuo, e o ac?ineuo aeeaioiuo iaei
io?aceeinue ia o?iaia eaeueoeey a nuai?ioea e?iae. Iaoaieciu,
iaania/eaathuea oaeoth aiiainoaoe/aneoth noaaeeueiinoue niaa?oaiii
i?ioeaiiieiaeiu: o iieiaeuo aeeaioiuo — nieaeaiea yene?aoeee eaeueoeey,
iiauoaiea aai niaea?aeaiey a einoyo, nieaeaiea o?iaiy eaeueoeeoiieia,
iiauoaiea o?iaiy iaoeiiei-yieaoaeeia; oiaaea eae o ac?ineuo aeeaioiuo —
ia?aoiay aeeiaieea oeacaiiuo iieacaoaeae.

Eeeie/aneei i?iyaeaieai ia?ooaiey eaeueoeeaaiai aiiainoaca, yaeyaony
ii/aeaiaiiay aieaciue, iae?iai?iiiaeueiue iaoiaaiac eioi?ie, eae
iieacaee iaoe enneaaeiaaiey, neeaaeuaaaony ec aeoeaaoeee
yieaoaeeiy?ae/aneie ?aaoeyoeee ?aiei-aeueaeinoa?iiiaie nenoaiu ia oiia
?aceiai oaiaoaiey i?iaeoeoeee eaeueoeeoiieia.

ssI?-iieacaoaee i?ioiiia oeaiaaie aiaeu e?iae e ii/e i?e caaieaaaieyo
ii/ae auniei niaoeeoe/iu, ei??aee?otho e io?aaeatho aeeiaieeo
iaoiaaiaoe/aneeo iae?iai?iiiaeueiuo iaoaieciia e ninoiyiey
aiiainoaoe/aneeo ooieoeee i?aaiecia, /oi iicaieyao eniieueciaaoue eo a
aeeooa?aioeeaeueiie aeeaaiinoeea aeaiiuo caaieaaaiee i?e
ne?eieia-oanoeo?iaaiee.

Eeth/aaua neiaa: eaeueoeeoiiei, yiaeiaaiiua iieieaeu, ii/ee,
ii/aeaiaiiay aieaciue, yaea?ii-iaaieoiue ?aciiain.

Panasenko M.V. Calcitonin and endogenous opioids relations in the
urolithiasis — Manuscript.

The dissertation for receiving candidate Medical sciences degree for
speciality 03.00.04 — biochemistry- Gerontology Institute Academy of
Medical Sciences Ukraine, Kiev, 1999 y.

The some questions of urolithiasis pathogenesis were shown in this
experimentally-clinical work. This disease was considered as disorder of
the exchange processes and water-salt balance, in comparison with other
kidney pathology. The studied violations of hormones spectrum were
modeled in the experiment, which was considered as calcium exchange
process model. Besides, we used NMR-spectroscopy as a new diagnostics
method of water-electrolytes balance at kidneys pathology. The analysis
of the results of carried out experiments allows to come to the
conclusion that the pathogenesis of urolithiasis was related with
disturbance regulation of endogenous opioids system (increasing
met-enkephalins level in the blood plasma) and considerable lowering of
calcitonin level on the background of already decreased level of this
hormone in the endemic regions of healthy inhabitants. Violation of
water-salt balance (calcium levels, sodium and potassium), is the
consequence of the violation of hormones spectrum. The study of
NMR-spectroscopy allows to use this method for differential diagnostics
of kidneys pathology and curing effectiveness control. Experimental
part of the work allows to draw a conclusion, that the violation in the
endogenous opioids, prostaglandins and calcitonin systems are connected
with each other. They are differ in depending on age and are the cause
of electrolyte violations and at urolithiasis.

Key words: calcitonin, endogenous opioids, urolithiasis, kidneys,
nuclear-magnetic resonance.

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