OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE

OI?AA?NEOAO

EAAAOe ??eia Noaiai?aia

OAeE 616.72-002-031.2-053.5/6

INIAEEAINO? NO*ANIIAI IA?AA?AO

O?II?*IEO A?O?EO?A O I?AeE?OE?A

( EE?I?EA, Ae?AAIINOEEA, E?EOAAIIss )

14.01.10 — iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ioi?iie caei?ia’y ae?oae ? i?aee?oe?a IIC Oe?a?ie, i. Oa?e?a.

Iaoeiaee eiinoeueoaio:

* aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie

EINOTH??IA Aaeeia Ieeeo?aia, Oe?a?inueeee iaoeiai-aeine?aeiee
?inoeooo ioi?iie caei?ia’y ae?oae ? i?aee?oe?a, i.Oa?e?a, aieiaiee
iaoeiaee ni?a?ia?oiee.

Io?oe?ei? iiiiaioe:

* aeieoi? iaaee/ieo iaoe, i?ioani?

NOEA*IAA Aaeeia ?aai?aia, Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, i?ioani? eaoaae?e oaeoeueoaonueei? iaae?ao??? c iaaee/iith
aaiaoeeith;

*aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie

?AAIIAA Ia?aa?eoa Aanee?aia E?einueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, caa?aeoaa/ eaoaae?e aini?oaeueii? iaae?ao???;

* aeieoi? iaaee/ieo iaoe, i?ioani?

Ae?EIAANUeEEE Ieeiea Iaaeiae/, Oe?a?inueeee iaoeiai-aeine?aeiee
?inoeooo aeeoy/i? eo?i?oieia?? ? o?c?ioa?ai??, IIC Oe?a?ie, i.?aiaoi??y,
aee?aeoi? ?inoeoooo.

I?ia?aeia onoaiiaa – ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII
Oe?a?ie, a?aeae?eaiiy aeeoa?aioe?eii? ae?aaiinoeee, i?io?eaeoeee ?
oa?ai?? caoai?thaaiue aioo??oi?o i?aai?a o ae?oae, i. Ee?a.

Caoeno a?aeaoaeaoueny “ 24 » /a?aiy 1999a. i 12 aiae.

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04. i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC Oe?a?ie (310022,
i. Oa?e?a, i?. Eai?ia 4).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?.Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee “ 21 » o?aaiy 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, aeioeaio Ia/a?aiei
E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oai?iae noaeia?a ( ON ) cia/ii iioe?ai? ?
/anoi ? i?e/eiith oei/aniai? iai?aoeacaeaoiino? ? ?aiiuei?
?iaae?aeecaoe?? oai?eo iieiaeiai a?eo (Ianiiiaa A.A. c niaao., 1997). O
inoaii? aeanyoe??//y niinoa??aa?oueny c?inoaiiy /anoioe ye caiaeueieo,
oae ? aeaaaia?aoeaieo o?aaeaiue iii?ii-?ooiaiai aia?aoo o an?o a?eiaeo
a?oiao, a oiio /ene? o ae?oae ? i?aee?oe?a (Iaeeoiaa I.E., 1991;
Aeieo?iaa I.A.,1997; Aiae?aaaa A.E. n niaao., 1998). ?acii c oei, o
oai?eo ia aoaiao noaoaaiai aeic??aaiiy, a ia??iae? iae?i-aiaeie?eiii?
ia?aaoaeiae i?aai?cio, ui noi?iaiaeaeo?oueny iniaeeainoyie
ooieoe?iioaaiiy a?eueoino? i?aai?a ? nenoai, ON — iaeiaio aea/ai?
(Einoth?eia A.I. n niaao., 1997 ). Ia?aaeon?i oea a?aeiineoueny aei
thaai?eueiiai o?ii?/iiai a?o?eoo (THOA), yeee ca?aeii c no/aniith
I?aeia?iaeiith eeaneo?eaoe??th ?aaiaoe/ieo caoai?thaaiue (?C) aeae?eaiee
a ie?aio ?oa?eeo. Aei oeueiai /ano ia anoaiiaeaii, /e ? THOA ie?aiith
iicieia?/iith oi?iith aai yaey? ca??io a?oio oai?ia ?c noiaeith
ee?i?/iith neiioiiaoeeith ? aeei?enoiao?oueny o ?ac? iaiiaeeeaino?
anoaiiaeaiiy iaeaaeiino? aei eiie?aoii? iicieia?/ii? oi?ie (Eocueieia
I.I., 1995; Oaeeia A.A., 1995; Prier A.M., 1993 ). Ia?aeiieea? aeieace
a?aeiinii i?aaii??iino? oaeeo oyaeaiue ia iniia? o?eaaeeo ee?i?/ieo
niinoa?aaeaiue ? ia?aee?i?/ieo aeine?aeaeaiue a?aenooi?. Noiae?noue,
iniaeeai ia ?aii?o aoaiao ?icaeoeo, a ee?i?/i?e neiioiiaoeoe?
noaeiaiaiai neiae?iio i?e THOA ? thaai?eueiiio ?aaiaoi?aeiiio a?o?eo?
(TH?A), ?aaeoeaieo a?o?eoao ( ?aA ), aie?eicoth/iio niiiaeeeia?o?eo? (
AN ), a ?iiae? e aeaaaia?aoeaieo i?ioeanao i?e a?aenooiino?
ae?aaiinoe/ieo ? aeeoa?aioe?aeueii-ae?aaiinoe/ieo e?eoa???a aeey
a?eueoino? aeacaieo caoai?thaaiue a i?aee?oeiaiio a?oe? oo?oaeiy?
nai?/anio ae?aaiinoeeo, ca?eueoo? no?iee anoaiiaeaiiy i?aaeeueiiai
ae?aaiico ? i?ecia/aiiy aaeaeaaoii? oa?ai?? a?ae aeae?eueeio i?nyoe?a
aei ?ieo ? a?eueoa, ui ni?ey? oi?ioaaiith oyaeeeo, i?ia?anoth/eo
aa??aio?a ia?aa?ao ? iani?eyoeeaeo iane?aee?a noaeiaiai? iaoieia??
(Ieeeoeia E.I. n niaao., 1996; Ai?eniaa O.I. n niaao., 1997; Amor B. et
al, 1989 ).

Aeine?aeaeaiiy inoaii?o ?ie?a ia o?eueee noaee iniiaith aei ci?ie
no?oeoo?e eeaneo?eaoe?? ?C, o oiio /ene? caoai?thaaiue noaeia?a a
aeeoy/iio ? i?aee?oeiaiio a?oe?, aea ? aecia/eee ?yae ni??ieo ?
iaae??oaieo ieoaiue, ui noinothoueny iaeii??aeiino? ie?aieo ee?i?/ieo
oi?i ? aa??aio?a ia?aa?ao TH?A. Aeeneooothoueny ieoaiiy: an? oi?ie TH?A
— ?aeeia caoai?thaaiiy /e naiino?ei? oai?iae. Iniaeeao i?iaeaio a
thiaoeueeiio a?oe? noaiiaeyoue ?aaeoeai? a?o?eoe, i?e yeeo iaei aea/ai?
aaiethoe?y noaeiaiaiai neiae?iio ? iane?aeee (Nie?iia A.N. n niaao.,
1990; Aeaenaaaa A.E. n niaao.. 1998, Fernandes-Vina M.A., 1990).

Cia/ou?noue ?ioiii? nenoaie a ?icaeoeo ?C, a oiio /ene? oai?ia
noaeia?a ? ?ieue ?ioiiiaoieia?/ieo i?ioean?a a o?aaeaii? niieo/ii?
oeaieie ( NO ) a?aeii? (Ianiiia A.E.,1994; Maerker-Alser G., 1990;
Romagnoli P. et al, 1992;Harris E.D., 1993 ). Iaeiae o i?aee?oe?a oe?
aniaeoe noaeiaiai? iaoieia?? aea/ai? iaaeinoaoiuei, iniaeeai i?e
THOA. ?o ?ica’ycaiiy aeicaieeei a ?ice?eoe ?ioeii? iaoai?cie oi?ioaaiiy
ia o?eueee THOA, aea TH?A, ?aA oa ?ioeo o?ii?/ieo a?o?eo?a (OA), a
oaeiae io?eiaoe iaai? aeieace a?aeiinii naiino?eiino? ? iaeii??aeiino?
ye iicieia?/ieo oi?i THOA ? TH?A.

Ieoaiiy noaoaai? aeaoa?i?iaoe?? ?C oa ?nioth/ee aeaiiai?aaeaiee
ca’ycie i?ae ?ioiiith ? aiaeie?eiiith nenoaiaie, ia?aaeon?i noaoaaeie
ai?iiiaie (Blalok J.K., 1989; Straube M. et al, 1989; Amento E.P., 1993
) ia?aaeaa/athoue ?o ?ieue ? a noaeiaia?e iaoieia?? o i?aee?oe?a.
Aea/aiiy ee?i?/ii? neiioiiaoeee OA o oai?eo ia ??cieo aoaiao noaoaaiai
aeic??aaiiy c o?aooaaiiyi ii?ooaiue a ?ioiiaaiac?, c aieo noaoaaeo
noa?i?ae?a ni?eyei a ye iie?ioaiith ae?aaiinoeee caoai?thaaiue a
i?aee?oeiaiio a?oe?, oae ? ooi/iaiith aaaeeeaeo eaiie iaoiaaiaco aeaii?
iaoieia??.

O ?icaeoeo ?C cia/ia ?ieue a?aeaiaeeoueny aaiaoe/iei oaeoi?ai.
Iniiai? iai?yie aaiaoe/ieo aeine?aeaeaiue oi?eathoueny ?ie? niaaeeiaino?
? na?aaeiaeua a aeaoa?i?iaoe?? caoai?thaaiue, aaiaoe/ii? no?oeoo?e
noeeueiino? oa ?? aca?iiae?y c ee?i?/iei iie?ii?o?ciii, anoaiiaeaiiy
oeio oniaaeeoaaiiy ? anioe?aoe?e aaiaoe/ieo ia?ea??a c oai?iaith
(Aaiaaieaineay E.E., 1989; Neaeaeueieeiaa N.I., 1991; Rahman M.U. et
al,1993; Walder R.L.,1993). Iaeiae i?e oaeeo caoai?thaaiiyo, ye THOA,
TH?A ? ?aA a i?aee?oeiaiio a?oe? iiae?ai? aeine?aeaeaiiy ia/eneaii?,
aeeiiai? o ??cieo iiioeyoe?eieo a?oiao ? nooo?ai a?ae??ciythoueny ca
?acoeueoaoaie. ?acii c oei, aeai? o oe?e aaeoc? iiaee a ni?eyoe
?icoeo?iaoe? noo? caoai?thaaiue, a?eueo /?oeiio aecia/aiith ?o
no?oeoo?e, ?icoe?aiith ae?aaiinoe/ieo iiaeeeainoae ? iie?ioaiith
i?iaiico.

E?eoaaiiy ON ? iaei??th ?c neeaaeieo i?iaeai i?aee?oeiai?
?aaiaoieia?? a ca’yceo c ??ciiiai?ooyi iicieia?/ieo oi?i c o?aaeaiiyi
noaeia?a, ee?i?/iei iie?ii?o?ciii, aeanoeaei a?eueoino? caoai?thaaiue,
iaaeinoaoiueith ?o aea/ai?noth. Iaea?eueo ?ic?iaeai? ieoaiiy e?eoaaiiy
TH?A. Cia/ia ?icoe?aiiy a?naiaeo aioe?aaiaoe/ieo cania?a ? iaeiie/aiiy
aeina?aeo ?o ee?i?/iiai canoinoaaiiy aeicaieeei ?noioii oaeineiiaeeoe
i?eioeeie ? iaoiaee oa?ai?? oe??? aaaeei? iaaeoae (Ianiiia A.E., 1996;
Ae?eiaanueeee I.I. ?c ni?aaao., 1997;.Eiaaeaiei A.I, 1997; Oaoaacyi E.A.
n niaao., 1997; A?oaiiiiaa A.O. n niaao., 1998; oa ?io. ). ?acii c oei,
? i?e oe?e iicieia?/i?e oi?i? ia ae??oai? ieoaiiy, ui noinothoueny
aeai?o i?aia?ao?a i?e ie?aieo ee?i?/ieo aa??aioao, iaiao?aeiino?
o?eaaeiai canoinoaaiiy aacenieo ? ai?iiiaeueieo i?aia?ao?a, ui cia/ii
cieaeo? iiaeeeaino? a?eueo ni?eyoeeaeo iane?aee?a caoai?thaaiiy.
Aeuacaaaeaia na?ae/eoue i?i iaaee/io ? nioe?aeueio cia/ou?noue aeaii?
iaoieia?? a i?aee?oeiaiio a?oe? ? aecia/a? aeooaeuei?noue i?iaeaie ?
i?iaaaeaiiai aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.
Aeena?oaoe?eia ?iaioa aeeiioaaeany a ?aieao nithcieo, ?anioae?eainueeeo
i?ia?ai (AeEIO ), aeainoi?iiiuei? i?aeia?iaeii? ni?ai?aoe? c Iieueuath ?
aoea o?aaiaioii oaeeo eiiieaenieo IAe?: “Aaeineiiaeaiiy iaoiae?a
?aiiueiai aeyaeaiiy ? ?aaa?e?oaoe?? i?aee?oe?a ?c caoai?thaaiiyie
noaeia?a, nenoaiiei /a?aiiei aia/aeii ? ?aaiaoeciii ia iniia? aea/aiiy
ee?i?ei-iaoiaaiaoe/ieo iniaeeainoae ?icaeoeo c iaoith i?aeaeuaiiy yeino?
?aaiaoieia?/ii? aeiiiiiae o aeaiiio a?eiaiio ia??iae?” ( iiia?
aea?aeaaii? ?a?no?aoe?? — 01.88.0069576, oeo? NI.19.14.00 12.88) ?
“E?eoaaiiy i?aee?oe?a, oai?eo ia caiaeuei? caoai?thaaiiy noaeia?a, ia
noaoe?iia?iiio, iie?ee?i?/iiio ? naiaoi?iiio aoaiao“ (iiia? aea?aeaaii?
?a?no?aoe?? — 3.0193 02964100, oeo? 01.05.00/005-93 ).

Iaoa ?iaioe — aaeineiiaeaiiy iaoiae?a ae?aaiinoeee, e?eoaaiiy ?
aeeniaina?iiai niinoa?aaeaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe.

A?aeiia?aeii aei oe?eueiai? onoaiiaee aoee aecia/ai? ianooii?
caaea/?:

1. Aea/eoe iniaeeaino? ii/aoeiaeo ee?i?/ieo i?iya?a, aaiethoe?th
neiioiiaoeee ? iane?aeee o?ii?/ieo a?o?eo?a ??cii? i?e?iaee o i?aee?oe?a
c o?aooaaiiyi ia??iaeo noaoaaiai aeic??aaiiy.

2. Aeine?aeeoe o i?aee?oe?a noai iaoaaie?cio niieo/ii-oeaieiieo
no?oeoo?, i?e?ioee?eoeyoe??, ie?aieo eiiiiiaio?a ?ioiii? nenoaie ? ai?no
noaoaaeo noa?i?ae?a i?e ??cieo ee?i?/ieo oi?iao o?ii?/ieo a?o?eo?a.

3. Aecia/eoe ?ieue aaiaoe/ieo oaeoi??a o ?icaeoeo thaai?eueiiai
o?ii?/iiai ? ?aaeoeaiiai a?o?eo?a ? ooi/ieoe anioe?aoe?? o?ii?/ieo
a?o?eo?a c aaiaoe/ieie ia?ea?aie.

4. C’ynoaaoe aca?iica’ycie noaoaaeo noa?i?ae?a, ?ioiieia?/ieo
iieaciee?a, eiiiiiaio?a niieo/ii? oeaieie ? aaiaoe/ieo ia?ea??a o
?icaeoeo o?ii?/ieo a?o?eo?a.

5. ?ic?iaeoe e?eoa??? aeeoa?aioe?aeueii? ae?aaiinoeee a?o?eo?a
??cii? i?e?iaee ? i?iaiicoaaiiy oyaeeino? ?o ia?aa?ao.

6. Aeaoe i?iiiceoe?? uiaei aeeoa?aioe?eiaaiiai e?eoaaiiy
ia?aaiaoi?aeieo a?o?eo?a, ioe?ieoe eiai aoaeoeai?noue ? aianoe ei?aeoeae
o aeeniaina?ia niinoa?aaeaiiy i?aee?oe?a c aeaiith iaoieia??th.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aia?oa aeaia oa?aeoa?enoeea
iniaeeainoae ia?aa?ao ? iane?aee?a THOA ? ?aA o i?aee?oe?a ia ie?aieo
aoaiao noaoaaiai aeic??aaiiy. Anoaiiaeaii, ui a ?aiiueiio ioaa?oaoiiio
ia??iae? niinoa??aa?oueny iaea?eueo iai?oanoia neiioiiaoeea noaeiaiaiai
neiae?iio OA ? ae?aaeai?noue aenoaeaoeaiiai eiiiiiaioa caiaeaiiy.

Aia?oa i?e ia?aaiaoi?aeieo a?o?eoao o i?aee?oe?a aecia/aii
ii?ooaiiy iai?io niieo/ii-oeaieiieo no?oeoo? ? i?e?ioee?eoeyoe??.
Anoaiiaeaii, ui i?e THOA ? ?aA ia?aaaaeii iathoue i?noea ci?ie o
iaoaaie?ci? i?ioaiae?eai?a c ia?a?iciiae?eii o?aeoe?e AAA: ia?inoaiiyi
ai?noo oiiae?i?oei- 6, -4- ? aea?iaoainoeueoao?a o oai?eo ia THOA ?
oiiae?i?oei-6-noeueoao?a o i?aee?oe?a, oai?eo ia ?aA. I?e TH?A
aecia/athoueny neeaaei? ci?ie a iai?i? eieaaaio, i’yciai? oeaieie ?
i?ioaiae?eai?a ?c ca?eueoaiiyi I, III ? cieaeaiiyi II o?aeoe?? AAA. I?e
THOA ? TH?A aeyaeaia o?nia caeaaei?noue i?ae ii?ooaiiyie iaoaaie?cio
eieaaaio ? aeoeaaoe??th oa?iaioo eoaeii? oinoaoace, i?ioaiae?eai?a ?
eenei? oinoaoace. Ca?eueoaiiy a?aeoeeaiue o iaoaaie?ci? i?ioaiae?eai?a
ia? ca’ycie c aeoeaaoe??th a aoii?aeuei?e eaioe? ?ioi?oaoo.

Anoaiiaeaii, ui ia a?aei?io a?ae TH?A, i?e yeiio niinoa??aathoueny
iaea?eueo ae?aaeai? ? iioe?ai? ci?ie, ye? noinothoueny on?o eaiie
i?e?ioee?eoeyoi?iiai ?onea, o oai?eo ia THOA ia?aaaaeathoue noaeeii?, a
iaio?e i??? — aioo??oiueinoaeeii? ?iceaaee, o i?aee?oe?a, oai?eo ia ?aA
— noaeeii? ii?ooaiiy. I?e OA aoaeue-yei? i?e?iaee nooi?iue
i?e?ioee?eoeyoi?ieo ci?i ia?inoa? c aeoeai?noth iaoieia?/iiai i?ioeano.

Aeyaeaii, ui ?ioiieia?/i? cnoae i?e OA ?icaeaathoueny ia oii?
ii?ooaiue a oa?aeoa?? ?aaoethth/iai aieeao noaoaaeo noa?i?ae?a ia
?ioii? ?aaeoe??. O oeeo i?ioeanao i?e THOA ? ?aA ia? i?noea o?niee
ca’ycie ?c ano?aae?ieii; i?e TH?A — iaeii/anii c ano?aae?ieii ?
oanoinoa?iiii. I?e oeueiio, a?aeoeeaiiy ai?noo noaoaaeo ai?iii?a i?e
o?ii?/ieo a?o?eoao ??cii? i?e?iaee oa?aeoa?ecothoueny
iaeiiiai?aaeai?noth ? i?iyaeythoueny cieaeaiiyi oanoinoa?iio ?
i?aeaeuaiiyi ano?aae?ieo.

Aeiaaaeaii, ui THOA ? ?aA a?aeiinyoueny aei caoai?thaaiue ?c
niaaeeiaith noeeuei?noueth, iie?aaiiei oeiii oniaaeeoaaiiy. Aecia/aii
anioe?aoeai? ca’ycee i?ae aea?iaoiae?o?/ieie iieacieeaie, aioeaaiaie HLA
? caoai?thaaiiyie. Ia?ea?ii THOA ? A3, A28, A40; ?aA — A10, A8;
?aoeeaeeaoth/iai ia?aa?ao ?aA — N3,4. I?e OA o i?aee?oe?a anoaiiaeaii
ca?aeiaiiy aea?iaoiae?o?/iiai ?enoiea ia iaeueoeyo ? aeieiiyo.

Iiaeeaeaii oyaeaiiy i?i iaoiaaiaoe/i? iaoai?cie OA o i?aee?oe?a.
Ia iniia? i?iaaaeaieo aeine?aeaeaiue ? aaaaoii??iiai noaoenoe/iiai
aiae?co io?eiaii aeieace cia/ouino? noaoaaeo ai?iii?a, ?ioiiiaoieia?/ieo
cnoa?a, aeoeaaoe?? e?ciniiaeueieo ? oeeoie?oe/ieo oa?iaio?a, aaiaoe/ieo
oaeoi??a ? iniaeeainoae ?o aca?iica’yce?a a ii?ooaiiyo iaoaaie?cio
niieo/ii-oeaieiieo no?oeoo? i?e eiaei?e iicieia?/i?e oi?i?.

Aia?oa a i?aee?oeiaiio a?oe? ?ic?iaeaii
aeeoa?aioe?aeueii-ae?aaiinoe/iee aeai?eoi aeey o?ii?/ieo a?o?eo?a ??cii?
i?e?iaee, a oaeiae e?eoa??? i?iaiico ia?aa?ao THOA ? ?aA.

Aeaii i?iiiceoe?? uiaei aeeoa?aioe?eiaaiiai e?eoaaiiy
ia?aaiaoi?aeieo o?ii?/ieo a?o?eo?a. Aecia/aii iniiai? i?eioeeie
aeeniaina?iiai niinoa?aaeaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe, ?
ioe?iaii aoaeoeai?noue ?o e?eoaaiiy c o?aooaaiiyi canoinoaaiiy ?ic?iaie
i?ioyaii o?eaaeiai i?iniaeoeaiiai niinoa?aaeaiiy.

Ia iniia? aeaieo ee?i?/ii? neiioiiaoeee ia ?aii?o aoaiao ?icaeoeo,
o?eaaeeo eaoaiianoe/ieo niinoa?aaeaiue ee?i?/ii? aaiethoe?? noaeiaiaiai
neiae?iio, ci?i a ?ioii?e nenoai? ? iaoaaie?ci? niieo/ii-oeaieiieo
no?oeoo?, aeyaeaieo niaoeeo?/ieo aaiaoe/ieo ia?ea??a ? aaaaoii??iiai
noaoenoe/iiai aiae?co (oaeoi?iiai aiae?co), oaeoi?ii? iiaeae?
iaoiaaiaoe/ieo aca?iica’yce?a iieaciee?a anoaiiaeaii, ui THOA ?
naiino?eiith iicieia?/iith oi?iith. Iath/e ?yae ni?eueieo ee?i?/ieo ?en
c TH?A, THOA a?ae??ciy?oueny a?eueo ni?eyoeeaei ia?aa?aii ?
iane?aeeaie.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aeei?enoaiiy
io?eiaieo aeaieo i?i iniaeeaino? no/aniiai ia?aa?ao caiaeueieo
caoai?thaaiue noaeia?a o i?aee?oe?a, o oiio /ene? ia aoaiao noaoaaiai
aeic??aaiiy, a oaeiae aeeoa?aioe?aeueii-ae?aaiinoe/ieo aeai?eoi?a aeey
noiaeeo ca ii/aoeiaeie ee?i?/ieie i?iyaaie OA iie?ioeoue ?o ?aiith
ae?aaiinoeeo ? i?enei?eoue i?ecia/aiiy aaeaeaaoii? oa?ai??.

Canoinoaaiiy aeaieo a?aeiinii “oaeoi??a ?eceeo” aeey iaio
ni?eyoeeaeo aa??aio?a ia?aa?ao THOA ? ?aA ? aeai?eoio ?o i?iaiico
ni?eyoeia oia?aaeaeaiith ?aoeeaeeaoaaiiy iaoieia?/iiai i?ioeano ?
i?enei?eoue ianoaiiy ?ai?n?? ? iaeoaeaiiy.

Aeei?enoaiiy a?aeiiinoae i?i ?ieue n?iaeii? aa?aaaoe?? ?C,
anoaiiaeaieo anioe?aoe?e OA c iaaieie aaiaoe/ieie ia?ea?aie
(aea?iaoiae?o?/ieie, aioeaaiaie HLA ) i?aeaeueoue ??aaiue ae?aaiinoeee
aeaii? iaoieia??.

Ai?iaaaeaeaiiy a i?aeoeeo ioi?iie caei?ia’y ?ic?iaeaieo
aeeoa?aioe?eiaaieo eiiieaen?a e?eoaaiiy oai?eo ia OA ? aeai?eoio
ioe?iee eiai aoaeoeaiino? ni?eyoeia nai?/aniiio i?iaaaeaiith
aaeaeaaoieo e?eoaaeueieo caoiae?a, iiia?aaeaeaiith iaio ni?eyoeeaeo
aa??aio?a ia?aa?ao ? iane?aee?a caoai?thaaiue ? aoaea i??ith ?o
aoi?eiii? i?io?eaeoeee.

Iaa?oioiaaia iaiao?aei?noue aeeiai?/iiai niinoa?aaeaiiy i?aee?oe?a
c OA aeicaieeoue ia aoaiao ?o ?icaeoeo nai?/anii ooi/ithaaoe oa?aeoa?
aaiethoe?? iaoieia?/iiai i?ioeano, i?iaiaeeoe iaiao?aeio ei?aeoe?th
oa?ai??, ui iie?ioeoue iane?aeee aeaii? iaoieia??.

Iniaenoee aianie caeiaoaa/a. I?e i?iaaaeaii? aeine?aeaeaiue ii
aeena?oaoe?? aaoi?ii naiino?eii i?iaiaeeany a?aea?? ? niinoa?aaeaiiy
oai?eo a ee?i?oe? ? ia aiaoeaoi?iiio aoai?, cae?aiiy aeaieo i?i n?i’th,
neeaaeaiiy ?iaeiaiae?a, aaiaaeia?/iee ? naa?aaaoe?eiee aiae?ce,
aea?iaoiae?o?/i? aeine?aeaeaiiy ? ?ic?aooiie aea?iaoiae?o?/ieo
iieaciee?a, a?ii?e?ineii?y eii’thieoeae ia u?eeii?e eaii?, oi?ioaaiiy
eiii’thoa?ii? aace iaaooeo aeaieo, i?aeaioiaea iaoa??aeo aeine?aeaeaiue
aeey iaoaiaoe/ieo ?ic?aooie?a, eiai noaoenoe/ia ia?iaea, ?ioa?i?aoaoe?y
? oai?aoe/ia ocaaaeueiaiiy io?eiaieo ?acoeueoao?a, a oaeiae ?ic?iaea
aeeoa?aioe?aeueii-ae?aaiinoe/ieo aeai?eoi?a aeey ie?aieo iicieia?/ieo
oi?i, aeai?eoi?a i?iaiico iaio ni?eyoeeaiai ia?aa?ao THOA ? ?aA,
i?eioeei?a ?aaa?e?oaoe?? i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe,
ei?aeoe?y oa?ai?? oai?eo ia noaoe?iia?iiio ? aiaoeaoi?iiio aoai?,
ioe?iea ?acoeueoao?a e?eoaaiiy, ai?iaaaeaeaiiy ?aeiiaiaeaoe?e
a?aeiia?aeii aei iniiaieo iieiaeaiue ? aeniiae?a ?iaioe, ia?iaea aeaieo
a?o/eciyii? ? ca?oa?aeii? e?oa?aoo?e. Aeei?enoiaoth/e aaaaoii??iee
noaoenoe/iee aiae?c, aaoi?ii noai?aia oaeoi?ia iiaeaeue iaoiaaiaoe/ieo
aca?iica’yce?a iieaciee?a aeey ??cieo OA ? eiioeaioe?y ?icaeoeo
thaai?eueiiai o?ii?/iiai a?o?eoo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Ca iniiaieie iieiaeaiiyie
?iaioe c?iaeaii aeiiia?ae? ia IV Ananithciiio c’?cae? ?aaiaoieia?a (
I?inuee, 1991), I?aeia?iaeiiio Neiiic?oi? ?aaiaoieia?a (Iineaa, 1986),
XVI Neiiic?oi? ?a?iiaenueeiai oiaa?enoaa inoaia?o?ieia?a (Iineaa,
1987), Ananithci?e eiioa?aioe?? ?aaiaoieia?a (Iineaa, 1988), II
c’?cae? ?aaiaoieia?a ?in?? (Iineaa 1997), Ieaioi? ?anioae?eainueeiai
oiaa?enoaa ?aaiaoieia?a (?aaii-O?aie?anuee, 1991), I ? II Eiia?an?
?aaiaoieia?a Oe?a?ie (Oa?iii?eue, 1993; Ee?a, 1997), I ? II c’?caeao
iaaee/ieo aaiaoee?a Oe?a?ie (Euea?a, 1988, 1995), Ananithciiio ?
I?aeia?iaeiiio neiiic?oiao aaiaoee?a (Oiaeueieoeueeee, 1988; Oa?e?a,
1994), ?anioae?eainueeiio neiiic?oi? (Iaeana, 1995), ?anioae?eainueeeo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo (Oa?e?a, 1990, 1992, 1993, 1995,
1996), ia can?aeaiiyo oiaa?enoaa ?aaiaoieia?a ? aeeoy/eo e?ea??a OIIO
(1988-1998).

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeothoueny a ee?i?oe? ?
eiinoeueoaoeai?e iie?ee?i?oe? Oe?a?inueeiai IAe? ioi?iie caei?ia’y
ae?oae ? i?aee?oe?a, aeeoy/eo a?aeae?eaiiyo ?aeiiieo ? iaeanieo
e?ea?aiue ? i?aee?oeiaeo eaa?iaoao iie?ee?i?e Oa?e?anueei?,
Iieoaanueei?, Noinueei?, Eoaainueei?, E??iaia?aaenueei?, Euea?anueei?,
?aaii-O?aie?anueei?, Ieeiea?anueei?, *a?i?aaoeueei? iaeanoae,
?anioae?ee E?ei.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue iioae?eiaaii 2 iaoiaee/i?
?aeiiaiaeaoe??, ?ic?iaeaii aeai?eoie aeeoa?aioe?aeueiiai ae?aaiico,
i?iaiico iani?eyoeeaiai ia?aa?ao caoai?thaaiue, ioe?iee aoaeoeaiino?
e?eoaaiiy. ?acoeueoaoaie ai?iaaaeaeaiiy ? i?aeaeuaiiy yeino?
ae?aaiinoeee, caiia?aaiiy o?ainoi?iaoe?? caoai?thaaiue a a?eueo oyaee?
aa??aioe ia?aa?ao, a oaeiae ?icaeoeo ?iaae?aeecaoe?? i?aee?oe?a.

Oai?aoe/i? iieiaeaiiy ? i?aeoe/i? ?aeiiaiaeaoe??, aeeeaaeai? a
aeena?oaoe?ei?e ?iaio?, aeei?enoiaoaaeeny i?e /eoaii? eaeoe?e ia eo?nao
noaaeoaaiiy ? ?ioi?iaoe?? aeey ea?ae?i?aaiaoieia?a, iaae?ao??a,
oa?aiaao?a i?aee?oeiaeo eaa?iao?a, ia eaoaae?ao oaeineiiaeaiiy e?ea??a,
a oaeiae a eaeoe?eiiio eo?n? aeey nooaeaio?a Oa?e?anueeiai aea?aeaaiiai
oi?aa?neoaoo.

Ioae?eaoe??. Ca ?acoeueoaoaie aeena?oaoe?? iioae?eiaaii 48
iaoeiaeo ?ia?o, o oiio /ene?: a aeo?iaeao — 18 ( 17 c ieo a aeo?iaeao
AAE Oe?a?ie), a iaoeiaeo ca??ieeao- 10, ?aooa – oace ? iaoa??aee
neiiic?oi?a, eiia?an?a, c”?cae?a, eiioa?aioe?e.

Ianya oa no?oeoo?a ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 327
noi??ieao iaoeiiieno, ?ethno?iaaia 46 oaaeeoeyie, 20 ?enoieaie ?
aeeth/a? anooi, iaeyae e?oa?aoo?e ( 2 ?icae?ee), aeani? aeai? oa ?o
iaaiai?aiiy ( 11 ?icae?e?a ), aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??. Nienie
aeei?enoaieo aeaea?ae e?oa?aoo?e aeeth/a? 546 iaeiaioaaiue, a oiio
/ene? 160 ?ia?o aaoi??a aeaeaeiai ca?oa?aeaey.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. C 1986 ii 1998 ?iee i?ae
niinoa?aaeaiiyi ciaoiaeeeiny 343 i?aee?oee 10 — 18 ?ie?a. Na?aae ieo
c iaoieia??th noaeia?a aoei 69 oai?eo ia THOA, 89 — TH?A, 119 — ?aA, 23
— aie?eicoth/ee niiiaeeeia?o?eo (AN). A?oio ii??aiyiiy noaiiaeee 43
i?aee?oee, oai?? ia inoaia?o?ic.

C iaoith iinoaaeaiiy ae?aaiic?a ea?oaaeeny no/aniith I?aeia?iaeiith
eeaneo?eaoe??th ?C, eeaneo?eaoe??th thaai?eueiiai ?aaiaoi?aeiiai a?o?eoo
(1980), No?aeii?a?iiaenueeeie ae?aaiinoe/ieie e?eoa??yie TH?A ( 1979 ),
e?eoa??yie A?A aeey AN ? e?eoa??yie ae?aaiinoeee IA, ?ic?iaeaieie
ni?a?ia?oieeaie ?inoeoooo ?aaiaoieia?? AII eieeoiueiai N?N? ( 1983 ).

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aiae?coaaeeny c o?aooaaiiyi
ianii?oiiai a?eo ? nooiaiy a?ieia?/ii? c??eino? oai?eo ( i?aioaa?oao,
?aii?e ioaa?oao, aeania ioaa?oao ).

Aea/aii aeaatho, ee?i?/io neiioiiaoeeo oa ?? aaiethoe?th a i?ioean?
o?eaaeiai ( 7-10 ?ie?a ) niinoa?aaeaiiy, ?aioaaiieia?/i? ci?ie a
iii?ii-?ooiaiio aia?ao? ? iane?aeee caoai?thaaiue noaeia?a, iniaeeaino?
?o ia?aa?ao ia aoaiao noaoaaiai aeic??aaiiy i?aee?oe?a.

Aeey ooi/iaiiy nooiaiy caiaeueieo ci?i, ia??ai? c ee?i?/iei
aiae?cii e?ia?, i?iaiaeeeiny aecia/aiiy na?iioei?aeo, ae?eii?ioa?ae?a,
n?aeiaeo eeneio, N- ?aaeoeaiiai a?eea, i?ioa?iia?aia. E??i oiai,
aeei?enoai? caaaeueiii?eeiyo? ee?i?/i? e?eoa???, ui oa?aeoa?ecothoue
nooi?iue caiaeueiiai i?ioeano a noaeiaao a aaeao: o?eaae?noue ?aieiai?
neooino?, /enei noaeia?a c aenoaeaoii, ?iaeaen i?eiooeino?, noaeiaiaee
?iaeaen, aieth/?noue a noaeiaao i?e ianeaiiio ?on? a ieo, /enei
aeoeaieo noaeia?a.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee aea/aiiy iieaciee?a
ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo. O — eaieo ?ioi?oaoo
aeine?aeaeoaaee oeyoii aecia/aiiy a?aeiinii? e?eueeino? O-e?ioioeeo?a
(A-?OE) a ia?eoa?e/i?e e?ia? ?aaeoe??th niiioaiiiai ?icaoeiooai?aiiy (
Jondae M. at al., 1972), ooieoe?iiaeueio aeoeai?noue O- e?ioioeeo?a
aecia/aee ca oanoaie aeanoo?ainoi?iaoe?? (?AOE) c o?oiaaiaaethoeieiii
(OAA), noaiiioeyoe?? O-e?ioioeeo?a — ca aeiiiiiaith oaio?e?iiai? i?iae
(Shore et al,1978). A — e?ioioeeoe (AAN-?OE) aecia/aeeny ?aaeoe??th
?icaoeiooai?aiiy c e?ioioeeoaie, nainea?e?ciaaieie aioene?iaaoeith aei
a?eo?ioeeo?a aa?aia (Bianco et al, 1970),. ??aaiue ?ioiiaeiaoe?i?a
ne?iaaoee e?ia? aeine?aeaeaiee iaoiaeii i?inoi? ?aae?aeueii?
?ioiiaeeooc?? ca G. Manchini (1965 ), oee?eoethth/? ?ioii? eiiieaene (
Oe?E ) — niaeo?ioioiiao?e/iei iaoiaeii ?c aeei?enoaiiyi ?ic/eio IYA
(No?o/eia I.O.n niaao., 1985). Eiiieaiaioa?ia aeoeai?noue ne?iaaoee
e?ia? aecia/aeany ca 50% aaiie?cii. Oaaioeeoa?ia eaiea ?ioi?oaoo
thoe?ithaaeanue ca aeiiiiiaith aecia/aiiy oaaioeeoa?iiai /enea oa
oaaioeeoa?iiai ?iaeaeno eaeeioeeo?a (Ianoa? A.O. n niaao. 1989).

Ai?no noaoaaeo noa?i?ae?a, oanoinoa?iio ? ano?aae?ieo,
e?aaoeie?iace, i?iaeia?io, eaeueoeeoii?io, aioeo?e aei AeIE
aeine?aeaeoaaeiny ?aae?i?ioiieia?/iei iaoiaeii c aeei?enoaiiyi iaai??a
noaiaea?oieo ?aaeoea?a ca?oa?aeieo o??i: Amersham ( Aiae?y ),
Pharmacia Diagnostik ( Oaaoe?y ), International CIS (O?aioe?y ),
Mallinckrodt Diagnostica ( I?ia//eia ), Diagnostic System Laboratories
INC ( NOA ), OII ? AIOA I?A ( I?inuee ).

Aeey ioe?iee iaoaaie?cio NO aecia/aeeny ae?eiciai?iiae?eaie ca
iaoiaeii ?.I.Ooa?i ?c ni?aaao. ( 1982 ), ienei?ie?i a na/? ca
iaoiaeeeith A.A.E?aeue ?c ni?aaao. (1968 ), caaaeuei?
oiiae?i?oeinoeueoaoe — ?aaeoe??th c ?eaaiieii, o?iiia? eeneioe — ca
iaoiaeeeith ?.A Ia?eo?’?ai? ?c ni?aaao.( 1974 ), aene?aoe?y eaeueoe?th
c na/ath, eenea oinoaoaca, eoaeia oinoaoaca — ca oi?o?eiaaieie
iaoiaeeeaie.

Noai i?e?ioee?eoeyoe?? aea/aiee ca iaoiaeii a?ii?e?ineii??
eii’thieoeae ia u?eeii?e eaii? UE-56 i?e ca?eueoaii? a 18 — 60 ?ac?a.
Aeei?enoaii e?euee?nii- ye?ni? e?eoa??? ioe?iee ia?eoa?e/iiai e?iaiia?ao
ca iaoiaeii I.A.Ooeuei?ii? (1979 ) ? ?.O.Einothe ( 1981 ).

Aaiaoe/i? aeine?aeaeaiiy aeeth/aee cae?aiiy aeaieo i?i n?i’th,
neeaaeaiiy ?iaeiaiae?a, aaiaaeia?/iee ? naa?aaaoe?eiee aiae?ce,
aea?iaoiae?o?eo. Aea/aii iniaeeaino? ia?aa?ao caoai?thaaiue ?c
o?aooaaiiyi iaoyaeaii? niaaeeiaino? ii ?C. I?e aiae?c?
aea?iaoiae?o?/ieo iieaciee?a aeei?enoaii iaoiaeeeo I.Cummis, C. Midlo (
1961 ), ioe?iaii 49 e?euee?nieo ? ye?nieo iciae ia e?a?e ? i?aa?e ?ooe?
ia??cii. Aeei?enoaii ?iaeaene Aeaieiaea?a, Oo?oaaoa ? Iiea.

Niaoeeo?/i?noue HLA aecia/aeany ca aeiiiiiaith noaiaea?oiiai
aeainooiaiaaiai e?ioioeeoioiene/iiai oanoo Oa?anae?. Aeei?enoaii
a?noioeioth/o iaiaeue aioe — HLA — ne?iaaoie ae?iaieoeoaa Naieo —
Iaoa?ao?cueeiai IAe? aaiaoieia?? ? ia?aeeaaiiy e?ia?, yea i?noeoue
iiii-, ae? — ? o?eniaoeeo?/i? aioene?iaaoee aei aioeaai?a HLA ia?oiai
eeano eieon?a A, A, N.

Aeey eiio?ieth aoa aeei?enoaiee ??aaiue iieaciee?a, ?ic?iaeaiee o
a?aeiia?aeieo eaai?aoi??yo ?inoeoooo.

E?eoaaiiy oai?eo i?iaiaeeeiny a noaoe?iia?? Oe?a?inueeiai IAe?
ioi?iie caei?ia’y ae?oae ? i?aee?oe?a, iaaeae? cae?enithaaeiny
aiaoeaoi?ii, a o /anoeie oai?eo — a naiaoi??? “Cae?aaieoey” i. ?aiaoi??y
? i?noeaaiio ea?ae?i?aaiaoieia?/iiio naiaoi??? c ei?aeoe??th
oa?aiaaoe/ieo caoiae?a eiaei? 6 i?nyoe?a a oiiaao ee?i?ee aai
iie?ee?i?ee ?inoeoooo. Uiaei ioe?iee aoaeoeaiino? e?eoaaiiy aeei?enoaii
ee?i?/i? ? eaai?aoi?i? iieacieee, ui oa?aeoa?ecothoue nooi?iue
caiaeueiiai i?ioeano ? oa?aeoa? eiai i?ia?anoaaiiy.

I?e ?ic?iaoe? aeai?eoi?a ae?aaiico ? i?iaiico caoai?thaaiue
noaeia?a canoiniaaii nenoaiii-?ioi?iaoe?eiee aiae?c ? iaoiaeeea
iaiaeii??aeii? iine?aeiaii? i?ioeaaeo?e Aaeueaea c aecia/aiiyi
?ioi?iaoeaiino? iciae ca aeiiiiiaith e?eoa??th Eoeueaaea.

Noaoenoe/ia ia?iaea io?eiaieo ?acoeueoao?a aeeiiaia ia
ia?niiaeueiiio eiii’thoa?? IAI ?N. Aeey aecia/aiiy aeinoia??iino?
a?aei?iiinoae iieaciee?a aeei?enoaii ia?aiao?e/i? ? iaia?aiao?e/i?
e?eoa??? Nouethaeaioa, A?eeieniia, O?oa?a. Aeey aeyaeaiiy oa?aeoa?o
aca?iica’yce?a i?ae iieacieeaie canoiniaaii ei?aeyoe?eiee aiae?c, a
oaeiae aaaaoii??iee noaoenoe/iee aiae?c — oaeoi?iee aiae?c ( iaoiae
aieiaieo eiiiiiaio, “varimax” iaa?oaiiy, ia/eneaiiy ?iaeea?aeoaeueieo
cia/aiue oaeoi?ieo aiane?a), (Aeaacyi N.A. n niaao.,1989). Aeei?enoaii
i?ia?aio Statgraphics’ plus 2.1 aeey Windows.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aea/aiiy aeaathoo ?
aaiethoe?? ??cieo ca i?e?iaeith o?ii?/ieo a?o?eo?a a i?ioean? 5 — 10
?ie?a i?iniaeoeaiiai niinoa?aaeaiiy i?aee?oe?a ? ?ao?iniaeoeaiee aiae?c
ee?i?/ii? neiioiiaoeee aeicaieeee aecia/eoe oa?aeoa?i? iniaeeaino?
no/aniiai ia?aa?ao oe??? iaoieia?? ? io?eiaoe aeai? a?aeiinii ??oaiiy
?yaeo aeeneon?eieo ieoaiue.

?acoeueoaoe aaaaoi??/iiai niinoa?aaeaiiy oai?eo ia THOA na?ae/eee
i?i oa, ui caoai?thaaiiy ia? ?yae iaaieo ee?i?/ieo ?en. O i?aee?oe?a
a aiaiiac?, ye i?aaeei, niinoa??aaeeny /ano? ?ioa?eo?aioi?
caoai?thaaiiy, aenieee ?ioaeoe?eiee ?iaeaen, aeyaeyeeny o?ii?/i?
aiaieua ?ioaeoe??, ia?aaeon?i oiicee?o ( 63,3 % ). Na?aae iiia?aaei?o
THOA /eiiee?a o 1/3 oai?eo cono??/aeany o?aaia noaeiaa, o /anoeie —
?ani??aoi?i? caoai?thaaiiy. O a?eueoino? oai?eo ca’ycie THOA c
yeei-iaaoaeue i?iaieoth/ei /eiieeii anoaiiaeoe ia aaeaeiny.

THOA oa?aeoa?ecoaaany i?aeaino?ei ia/aeii, iaaenieith aeoeai?noth ?
iiiiie?aia?oeeoey?ieie o?aaeaiiyie, ia?aaaaeii ci?iaie o eie?iieo (78,3
%) ? aii?eeiainoiiieeo ( 33,3 % ) noaeiaao, ??aeei — a noaeiaao aa?oi?o
e?ioe?aie. Aaea ia ii/aoeiaeo aoaiao oai?iae a?aecia/aeeny iaai?
caeiiii??iino? a ?? ?icaeoeo. Iaeaea o iieiaeie oai?eo ( 47,8 % ) iaei
i?noea caeo/aiiy aei iaoieia?/iiai i?ioeano ia?ieo noaeia?a, iaeiae,
neiao?e/ia o?aaeaiiy ae??aieo noaeia?a, ui niinoa??aa?oueny i?e TH?A,
aoei a?aenooi?. Ia a?aei?io a?ae TH?A, i?e THOA ??aeei ?icaeaaeeny ci?ie
a 4 ? a?eueo noaeiaao, ia aeyaeaii ?aieiai? neooino?, ao?neo?a,
o?aaeaiiy i?aaio ci?o. E??i oiai, i?e THOA, a ii??aiyii? c TH?A, ia
anoaiiaeaii aeano?oeoe?? e?noeiai? oeaieie. Eeoa o 23,2 % i?aee?oe?a
ia ?ai?oa i?ae /a?ac ??e a?ae aeaathoo a?o?eoo iaa i?noea inoaiii?ic,
aea i?ia?anoaaiiy ?aioaaiieia?/ieo ci?i a i?ioean? iiaeaeueoi?
aaiethoe?? oai?iae aoei a?aenooi?. Iacaaaeath/e ia cia/io o?eaae?noue
a?o?eoo (a na?aaeiueiio — 120,7 aei?a ), ae?aaeai?noue eiai aoea
iii??iith, o oiio /ene? nooi?iue iaa?yeeino? noaeia?a ? aieth/ino? a ieo
i?e aeoeaieo ? ianeaieo ?ooao. Noaeiaiaee neiae?ii i?e THOA iaa
noeeuei?noue aei ?aoeeaeeaoaaiiy, iniaeeai /anoi ia ae?oaiio ? o?aoueiio
?ioe? caoai?thaaiiy ( 42,6% ? 41,7% a?aeiia?aeii ). ?acii c oei,
aaiethoe?y noaeiaiaiai neiae?iio i?e THOA, iacaaaeath/e ia ia??iaee/ia
?aoeeaeeaoaaiiy iaoieia?/iiai i?ioeano, iaea aeia?iye?niee oa?aeoa? ? ia
e?iaoeue niinoa?aaeaiiy o a?eueoino? oai?eo (89,9 %) ianoaea no?eea
?ai?n?y c oe?eeiaeoei cieeiaiiyi iciae o?aaeaiiy noaeiaiaiai aia?aoo. A
oe?eiio, a?aenooi?noue ee?i?/ieo i?iya?a oai?iae i?ioyaii 5 ?ie?a ia
oii? oe?eeiaeoiai neanoaaiiy iaaeeeaiaioicii? oa?ai?? aoei iaie
?icoe?iaii ye aeaeoaeaiiy (26,0%). Ia iniia? aiae?co ee?i?/ii?
neiioiiaoeee aoee aeae?eai? ianooii? aa??aioe ia?aa?ao THOA: ??aeei
?aoeeaeeaoth/ee (66,7%) ? /anoi ?aoeeaeeaoth/ee (33,3%). ??aeei
?aoeeaeeaoth/ee ia?aa?a ia?aaeaa/aa ia??iaee/ia caaino?aiiy oai?iae c
e?euee?noth ?aoeeaeea?a ia a?eueoa 1 ?aco ca 2 ?iee, /anoi
?aoeeaeeaoth/ee — aa??aio caoai?thaaiiy c ?aoeeaeeaaie ui??/ii aai
a?eueo 1 ?aco ca ??e.

Aeyaeaii iniaeeaino? i?iya?a THOA o i?aee?oe?a c ??ciei ??aiai
a?ieia?/ii? c??eino?, ye? na?ae/eee i?i iaai? aiaeie?eii? aieeae ia
ee?i?/io neiioiiaoeeo caoai?thaaiiy o ??ci? ia??iaee ioaa?oaoo.
Anoaiiaeaii, ui iaea?eueo ae?aaeaia ee?i?ea a?o?eoo c yne?aaei
aenoaeaoeaiei eiiiiiaioii caiaeaiiy ? eiai /ano? ?aoeeaeeae
niinoa??aathoueny o ?aiiueiio ioaa?oaoiiio ia??iae?. O aeania
ioaa?oaoiiio ia??iae? ia?aaaaeaee ie?aia?oeeoey?i? o?aaeaiiy,
ciaiooaaeany nooi?iue ee?i?/ieo i?iya?a a?o?eoo ? eiai o?eaae?noue.

?ioiieia?/i? aeine?aeaeaiiy aeyaeee i?e THOA ii?ooaiiy a O- ? A
nenoaiao ?ioi?oaoo. Anoaiiaeaii o ii??aiyii? ?c caei?iaeie cieaeaiiy o
a?eueoino? oai?eo a?aeiinii? e?eueeino? O-e?ioioeeo?a (?<0,001) oa ?o i?ie?oa?aoeaii? aeoeaiino? (? <0, 001). I?aeoaa?aeaeaiiyi ?icaeoeo aaoi?ioiieo i?ioean?a aoei cieaeaiiy e?eueeino? oaio?e?i/ooeeaeo e?ioioeeo?a (noi?ani??a) (? <0,05). O i?aee?oe?a, oai?eo ia THOA, iaee i?noea oaeiae a?aeoeeaiiy a iiiioeeoa?ii-oaaioeeoa?i?e nenoai? o aeaeyae? cieaeaiiy aeoeaiino? iiiioeeoa?ii-oaaioeeoa?ieo ee?oei. Iaea?eueo ae?aaeai? ?ioiieia?/i? cnoae niinoa??aaeeny i?e /anoiio ?aoeeaeeaoaaii? iaoieia?/iiai i?ioeano o ?aiiueiio ioaa?oaoiiio ia??iae? ? aeyaeyeeny a?eueo /anoei cieaeaiiyi O-e?ioioeeo?a ? i?aeaeuaiiyi A-e?ioioeeo?a, IgA, IgM, Oe?E, eiiieaiaioo (?<0,001 - 0,05). Anoaiiaeaii, ui ii i??? ia?inoaiiy aeoeaiino? iaoieia?/iiai i?ioeano caa??aaeeny noiae? caeiiii??iino? a ?ioiieia?/ieo cnoaao, aea a oie aea /an a?aei?/aeiny ca?eueoaiiy /anoioe a?aeoeeaiue a O- nenoai? ?ioi?oaoo ? aeyaeaiiy Oe?E (? < 0,001). I?e ca?eueoaii? o?eaaeino? caoai?thaaiiy aei o?ueio ?ie?a o 1/3 i?aee?oe?a iaa?oue i?e ianoaii? ee?i?/ii? ?ai?n?? niinoa??aaeiny cieaeaiiy e?eueeino? ? i?ie?oa?aoeaii? aeoeaiino? O-e?ioioeeo?a, a na?aaei?e ??aaiue IgA ? IgI aoa aeuei, i?ae o caei?iaeo (? <0,001). I?e o?eaaeino? oai?iae i'youe ?ie?a o 1/5 i?aee?oe?a caa??aaeiny ciaioaiiy e?eueeino? O-e?ioioeeo?a ? i?aeaeuaiiy ??aiy IgM. Oae? ii?ooaiiy na?ae/eee i?i no?ee? a?aeoeeaiiy a ?ioiieia?/iiio aiiainoac?, ui iiaei aieeaaoe ia ?icaeoie ?aoeeaeea?a a?o?eoo. Oa?aeoa? i?e?ioee?eoeyoi?ieo ii?ooaiue i?e THOA a?aeiia?aeaa iii??i?e aeeaei? ?ioiieia?/ieo cnoa?a. Noaeeii? ci?ie (70,6%) aeyaeyeeny a iaaaeeeiio /ene? noaeei o aeaeyae? caeaenoino?, ia??aiii??iino? eae?a?o, c??aeea - ?oai?/ieo cii ? iaeeie/ieo aiaa??ci (9,7%). Aioo??oiueinoaeeii? ii?ooaiiy (53,4%) oa?aeoa?ecoaaeeny iiyaith, ia?aaaaeii o aaioeao, niia?eueiaiiy e?iaioiea, ae??aiica?ienoi? aa?aaaoe?? a?eo?ioeeo?a. ?iceaaee a noaeeiao aoeueaa?ii? eii'thieoeae ia aoee no?eeeie, ?c ca?eueoaiiyi o?eaaeino? caoai?thaaiiy ? ianoaiiyi ?ai?n?? aiie cieeaee ? ciiao c'yaeyeeny i?e caaino?aii? iaoieia?/iiai i?ioeano. Ia??ai? c oeei, no?eeee niaci a?oa??ie aoa iani?eyoeeaei iieacieeii a?aeiinii o?eaaeino? a?o?eoo. A?aeiiee aieea ?ioiiiaoieia?/ieo i?ioean?a ia iaoaaie?ci niieo/ii? oeaieie (Na?ia A.A. n niaao., 1981). Anoaiiaeaii, ui i?e THOA iaee i?noea iii??i? a?aeoeeaiiy a iai?i? niieo/ii-oeaieiieo no?oeoo?, ye? ia?aaaaeii oa?aeoa?ecoaaeeny ii?ooaiiyie a iaoaaie?ci? i?ioaiae?eai?a (75,7%). I?aeoaa?aeaeaiiyi oeueiio aoei i?aeaeuaiiy noia?ieo AAA c ia?a?iciiae?eii ai?noo ?o o?aeoe?e: ca?eueoaiiy oiiae?i?oei-6-noeueoao?a, oiiae?i?oei-4-noeueoao?a, aea?iaoainoeueoao?a ? cieaeaiiy ea?aoai - ? aaia?ainoeueoao?a. E??i oiai, anoaiiaeaii i?aeaeuaiiy aeoeaiino? oa?iaio?a, ui ia??aeei niinoa??aa?oueny i?e ?icaeoeo eaoaaie?/ieo i?ioean?a a niieo/i?e oeaiei?. Aeyaeaii ca?eueoaiiy aeoeaiino? eenei? oinoaoace, ??aeoa - eoaeii? oinoaoace (?< 0,001 - 0,05). C o?aooaaiiyi ??aiy i?iaeia?io ?noioieo ii?ooaiue iaoaaie?cio i'yciaeo no?oeoo? ia aoei. Ci?ie a eaeueoe??aiio iai?i? (ca aeaieie aene?aoe?? eaeueoe?th, e?eueeino? eaeueoeeoii?io) o a?eueoino? oai?eo ia a?aei?/aeeny. Oea a?aeiia?aeaei a?aenooiino? ?aioaaiieia?/ieo iciae aeano?oeoe?? e?noeiai? oeaieie. Oaeei /eiii, ia iniia? o?eaaeeo niinoa?aaeaiue anoaiiaeaii aeineoue /?oeo ee?i?/io ie?anethaai?noue aeaii? iaoieia?? a aeaatho? ? ia aoaiao aaiethoe?? c iii??ieie ?ioiieia?/ieie cnoaaie a ee?oeii?e ? aoii?aeuei?e eaioe? ?ioi?oaoo, ye? iinyoue aaoi?ioiiee oa?aeoa?, ? iniaeeainoyie ii?ooaiue iaoaaie?cio niieo/ii-oeaieiieo no?oeoo?, ia?aaeon?i i?ioaiae?eai?a, ui aeicaiey? ?icaeyaeaoe THOA ye eiie?aoio iicieia?/io oi?io. I?e?ioee?eoeyoi?i? ii?ooaiiy i?e THOA ia ? niaoeeo?/ieie ? ia?inoathoue o a?aeiia?aeiino? c nooiaiai aeoeaiino? iaoieia?/iiai i?ioeano. Aea/aiiy ee?i?/ii? neiioiiaoeee ?aA iieacaei, ui i?ia?aeieie iciaeaie caoai?thaaiiy ? aneiao?e/i? iiiiie?aia?oeeoey?i? o?aaeaiiy ( 89,9 % ), ia?aaaaeii noaeia?a ieaei?o e?ioe?aie, i?i?iaeueia caiaeueia aeoeai?noue, i?aeaino?ee ii/aoie. O i?aee?oe?a, ye ? o aei?ineeo, ?aA ?icaeaaany ia oii? aai i?ney ia?aianaieo iaia?aaeiaei? ?ioaeoe?e c ia?aaaaeaiiyi iinoiiniaeioeiaeo aa??aio?a. Na?aaeiy o?eaae?noue a?o?eoo noaiiaeea 64,4 aei?. Iaea?eueo yne?aaa ee?i?ea a?o?eoo c ae?aaeaiei aenoaeaoeaiei eiiiiiaioii, aieueiaei neiae?iiii, aea e oaeaeeith ?iaiethoe??th ci?i niinoa??aaeany o ?aiiueiio ioaa?oaoiiio ia??iae?. Iaaio noiae?noue ?c neiioiiaoeeith noaeiaiaiai neiae?iio o aei?ineeo c iinoiiniaeioeiaei aa??aioii oai?iae ( Eaioeia E.A. n niaao., 1991 ) iaee i?aee?oee aeania ioaa?oaoo, o yeiio /ano?oa, i?ae ia iiia?aaei?o aoaiao noaoaaiai aeic??aaiiy aoee o?aaeai? ae??ai? noaeiae noii, ?icaeaaeeny ia o?eueee ie?aia?o?eoe, aea e iie?a?o?eoe (? < 0,01 ) Ioe?iea oa?aeoa?o aaiethoe?? noaeiaiaeo ci?i aeicaieeea aeae?eeoe aeaa aa??aioe ia?aa?ao ?aA: ?aoeeaeeaoth/ee (63,0% ) ? ia?aoeeaeeaoth/ee ( 36,9 % ). ?aoeeaeeaoaaiiy iaoieia?/iiai i?ioeano ia caaaeaee iaei ca'ycie c iiaei i?iieeiaiiyi ?ioaeoe?eiiai aaaioa ?, i/aaeaeii, aoei coiiaeaii o?eaaeith eiai ia?nenoaioe??th a i?aai?ci? oai?iai, ui i?aeoaa?aeaeoaaeiny iiceoeaieie oeo?aie aioeo?e, ia?aaeon?i aei oeai?ae?e. Oea aeicaiey?, ye ? o aei?ineeo (Aaaaaaia N.A., 1985; Neaeaeueieeiaa N.I., 1991 ), aiai?eoe i?i o?ii?/iee ia?aa?a o?iaaiieo a?o?eo?a. Caaaeii, ?aA o i?aee?oe?a oa?aeoa?ecoaaany ni?eyoeeaeie iane?aeeaie: ia e?iaoeue niinoa?aaeaiiy o 2/3 oai?eo a?aei?/aany iiaiee cai?ioiee ?icaeoie ? no?eea a?aenooi?noue ci?i a o?aaeaieo noaeiaao, ui aoei ?icoe?iaii ye aeaeoaeaiiy. Ca aeaieie ee?i?ei-?ioiieia?/ieo c?noaaeaiue aeyaeaii a?aeiia?aei?noue ae?aaeaiino? ee?i?/ieo iciae e ?ioiieia?/ieo cnoa?a. Acaaae?, /anoioa ? nooi?iue ?ioiieia?/ieo ii?ooaiue i?e ?aA aoee iaio ae?aaeai?, i?ae i?e THOA. Anoaiiaeaii iii??ia cieaeaiiy a?aeiinii? e?eueeino? ? ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a, i?aeaeuaiiy ??aiy IgA ? IgI ( ? <0,01 ). O /anoeie i?aee?oe?a aeyaeyeeny Oe?E (25,6%). O oai?eo ?c ?aoeeaeeaoth/ei ia?aa?aii aeacai? a?aeoeeaiiy a ee?oeii?e ? aoii?aeuei?e eaioe? ?ioi?oaoo niinoa??aaeeny /ano?oa, i?ae c ia?aoeeaeeaoth/ei (? <0,05 - 0,001). Noiae?, aea a?eueo ae?aaeai? ci?ie a eaieao ?ioi?oaoo a?aei?/aeeny o ia??iae? iiyae aoi?eiieo noaoaaeo iciae. ?c ca?eueoaiiyi o?eaaeino? ?aA aei i'yoe ?ie?a ?ioiieia?/i? cnoae caa??aaeeny o iiiaeeiieeo aeiaaeeao. I?e?ioee?eoeyoi?i? ii?ooaiiy o oai?eo ia ?aA aeyaeyeeny ia?aaaaeii o aeaeyae? noaeeiieo ?iceaae?a (62,5%), caa??aaeeny eeoa a ia??iae? ee?i?ei-eaai?aoi?ieo i?iya?a ? i?e ianoaii? ?ai?n?? cieeaee. Ci?ie a niieo/ii-oeaieiieo no?oeoo?ao i?e ?aA iineee eaoaaie?/iee oa?aeoa?. O a?eueo?e i??? no?aaeaeaa iaoaaie?ci i?ioaiae?eai?a, i?e/iio noia?i? AAA iaee ?iaeoee o?aeoe?eiee ?iciiae?e, a ii??aiyii? c THOA, ui aeyaeyeiny o a?eueoino? oai?eo (61,5%) i?aeaeuaiiyi oiiae?i?oei-6-noeueoao?a ? cieaeaiiyi ?ioeo o?aeoe?e. O oeeo i?ioeanao cia/ia ?ieue a?aeaiaeeeany eene?e oinoaoac?, i?aeaeuaiiy iieaciee?a yei? anoaiiaeaii o 69,2% i?aee?oe?a. Io?eiai? aeai? na?ae/eee i?i ?noioi? a?aei?iiino? i?ae ?aA ? THOA a iaoaaie?ci? i?ioaiae?eai?a. O oie aea /an i?e oeeo caoai?thaaiiyo iaea i?noea noiae?noue o a?aenooiino? ii?ooaiue eaeueoe??aiai iai?io ? iaoaaie?cio i'yciaeo no?oeoo?, ui i?aeoaa?aeaeoaaeiny ? aeaieie o?eaaeeo niinoa?aaeaiue. No/aniee TH?A o i?aee?oe?a ye a aeaatho?, oae ? ia aoaiao aaiethoe?? a?ae??ciyany iie?ii?o?ciii ee?i?/ii? neiioiiaoeee c ia?aaaaeaiiyi noaeiaiai? oi?ie (60,7% ), iii??ii? aeoeaiino? ( 71,9 % ), iia?eueiiai i?ia?anoaaiiy iaoieia?/iiai i?ioeano (74,2 %). Aeey TH?A aoee oa?aeoa?i? ci?ie o eie?iieo, aii?eeiainoiiieo, i?iiaiaaicai'ynoeiaeo ? ae??aieo noaeiaao eenoae, ??aeoa - a e?eoueiaeo, ae??aieo noaeiaao noii, oeeiiio a?aeae?e? o?aaoa, neiao?e/i? o?aaeaiiy ae??aieo noaeia?a ( 57, 3 %), ?aieiaa neoo?noue, ai?io?io??, ao?neoe ? aei?o a ii?iaeieio noaeiaa. Na?aaeiy o?eaae?noue aeoeaiiai a?o?eoo noaiiaeea 238,2 aei?a. ?aioaaiieia?/i? ci?ie a noaeiaao iaee i?noea o 76, 4 % i?aee?oe?a, a?aeiia?aeii II - IV noaae?yi - o 52,8 %. O?aaeaiiy i?aaio ci?o cono??/aeiny ia/anoi ( 6, 7 % ) ? ia?aaaaeii aeyaeyeiny o aeaeyae? no?eeiai aeainoi?iiiueiai oaa?oo, ? eeoa o ie?aieo oai?eo - no??/eiiiae?aii? aeeno?io?? ?ia?aee, eaoa?aeoe. Na?aae aa??aio?a noaeiaiai-a?noea?aeueii? oi?ie ia?aaaaeaa neiae?ii No?eea (51,4% ), o 1/3 anoaiiaeaii TH?A c ie?aieie a?noea?eoaie, ??aeoa cono??/aany aea?ainaioe/iee aa??aio ( 11,4 % ). Iae/ano?oa ?icaeaaany ea?aeeo, aaiaoeo, nieai?o, ??aeoa - iao?iiao?y. Ia aoaiao aaiethoe?? caoai?thaaiiy i?ia?anoaaiiy ci?i a noaeiaao ? aioo??oi?o i?aaiao a?aeaoaaeiny a ia?o? 3 ?iee oai?iae, ia 5 ?ioe? oaiie eiai cieaeoaaeeny aaeai?, 10-iio - a 3 ?ace. I?e iiiiie?aia?oeeoey?iiio TH?A i?ia?anoaaiiy niinoa??aaeiny cia/ii ??aeoa, i?ae i?e iie?a?oeeoey?iiio ( ? < 0,01 ) ? /ano?oa - oe?eeiaeoee cai?ioiee ?icaeoie noaeiaiaiai neiae?iio ( ? < 0,01 ). ?c ca?eueoaiiyi o?eaaeino? noaeiaiai? oi?ie TH?A a?aei?/aeiny c?inoaiiy /enea oai?eo c iiaiei cai?ioiei ?icaeoeii ? no?eeith a?aenooi?noth caiaeueieo ci?i a noaeiaao, ui ia 10 ?ioe? oai?iae noaiiaeei 22,71%. O /anoeie oai?eo (11,4%) niinoa??aaeany e?ea?aeaoe?y ? a?aenooi?noue i?ioyaii iiaeaeueoeo ?ie?a niinoa?aaeaiiy a?noea?aeueieo o?aaeaiue c a?aeiiaeaiiyi ooieoe?iiaeueii? caeaoiino? i?aaio, ui na?ae/eei i?i o?ainoi?iaoe?th noaeiaiai- a?noea?aeueii? oi?ie a noaeiaiao. Anoaiiaeaii a?aei?iiino? a ee?i?/i?e neiioiiaoeoe? TH?A o i?aee?oe?a ia aoaiao noaoaaiai ?icaeoeo. I?e iiya? aoi?eiieo noaoaaeo iciae, a ?aiiueiio ioaa?oaoiiio ia??iae?, a ii??aiyii? c aeania ioaa?oaoii, /ano?oa aeyaeyeeny iciaee e?noeiai-o?yuiai? aeano?oeoe?? ( ?< 0,01 ), yne?aa?oei aoa nooi?iue i?iya?a a?o?eoo ? a?eueoa eiai o?eaae?noue ( ? < 0,05 ). I?e noaeiaiai - a?noea?aeuei?e oi?i? ae?aaeai?noue aenoaeaoeaieo i?iya?a, aieueiaiai neiae?iio, i?ia?anoaaiiy noaeiaiaeo o?aaeaiue /ano?oa aecia/aeeny o oai?eo a i?aioaa?oaoiiio ia??iae?. Caaaeii, ia?aaaaeaiiy noaeiaiai? oi?ie caoai?thaaiiy, iii??ii? aeoeaiino? ? iia?eueiiai i?ia?anoaaiiy iaoieia?/iiai i?ioeano, ianoaiiy a?eueo i?ae o 1/3 oai?eo ia oii? e?eoaaiiy no?eei? ?ai?n?? c ?iaiethoe??th ci?i a noaeiaao, o?ainoi?iaoe?y o /anoeie i?aee?oe?a noaeiaiai- a?noea?aeueii? oi?ie o noaeiaiao aeicaiey? aaaaeaoe, ui TH?A o i?aee?oe?a ia no/aniiio aoai? ia? oaiaeaioe?th aei a?eueo ni?eyoeeaiai ia?aa?ao. Io?eiai? ?acoeueoaoe aeine?aeaeaiiy ocaiaeaeothoueny c aeaieie A.I.Ianiiiai? ?c ni?aaao. (1997) i?i ?icaeoie i?e TH?A aaoi?ioiiiai caiaeaiiy. Aeyaeaii ae?aaeaiee e?ioioeeoa?iee aeenaaeain, ?ioii?aaoeyoi?i? cnoae, ye? i?iyaeyeeny cieaeaiiyi e?eueeino? O-e?ioioeeo?a, oaio?e?i/ooeeaeo e?ioioeeo?a (noi?ani??a), i?ie?oa?aoeaii? aeoeaiino? O-e?ioioeeo?a. E??i oiai, anoaiiaeaii i?aeaeuaiiy e?eueeino? A-e?ioioeeo?a, IgA, IgM, IgG, eiiieaiaioo, ??aiy Oe?E, aioeo?e aei AeIE, iiyao ?O (50,6%), cieaeaiiy aeoeaiino? iiiioeeoa?ii-oaaioeeoa?ieo ee?oei. ?ioiieia?/i? cnoae aoee iaea?eueo cia/i? i?e noaeiaiai - a?noea?aeuei?e oi?i?, iie?a?oeeoey?iiio aa??aio? TH?A ? o i?aee?oe?a a ia??iae? iiyae aoi?eiieo noaoaaeo iciae. Ci?ie a i?e?ioee?eoeyoi?iiio ?one? o oai?eo ia TH?A ?icaeaaeeny a?aeiia?aeii aei ae?aaeaiino? ?ioiiiaoieia?/ieo ?aaeoe?e, aeoeaiino? caiaeueiiai i?ioeano ? ia a?aei?io a?ae THOA ? ?aA ioiiethaaee an? eaiee i?e?ioee?eoeyoe?? (noaeeii? - 92,3%; aioo??oiueinoaeeii? - 76,3%; ia?eaaneoey?i? 34,2%), /ano?oa cono??/aeeny i?e noaeiaiai-a?noea?aeuei?e oi?i?, oaeaeei i?ia?anoth/iio ia?aa?ao ? no?eei caa??aaeeny iaa?oue i?e ianoaii? ?ai?n?? o 1/3 i?aee?oe?a, aea ia?aaaaeii o aeaeyae? noaeeiieo ii?ooaiue. Ioe?ithth/e a?aeoeeaiiy a iai?i? niieo/ii-oeaieiieo no?oeoo? i?e TH?A, iio??aii cacia/eoe ?o ?noioio a?aei?ii?noue ? cia/io ae?aaeai?noue a ii??aiyii? c THOA ? ?aA. Ia?aaeon?i a?aei?/aeeny ci?ie a iaoaaie?ci? eieaaaio ? i?ioaiae?eai?a, ye? i?iyaeyeeny o a?eueoino? i?aee?oe?a i?aeaeuaiiyi ienei?ie?io, ia?a?iciiae?eii ai?noo an?o o?aeoe?e AAA ?c ca?eueoaiiyi oiiae?i?oei-6-noeueoao?a, ea?aoai-aaia?ai-noeueoao?a, oiiae?i?oei-4-noeueoao?a, aea?iaoainoeueoao?a, aenieith aeoeai?noth oeeoie?oe/ieo ? e?ciniiaeueieo oa?iaio?a. A?aeoeeaiiy a iieacieeao i?iaeia?io aeacoaaee ia aeoeai? aeano?oeoeai? i?ioeane a i'yciaeo no?oeoo?ao, ui a?aeiia?aeaei /anoio? e ae?aaeaiino? ee?i?/ieo i?iya?a ai?io?io?e. Aeyaeaii ci?ie a eaeueoe??aiio iai?i?, i?i ui na?ae/eei i?aeaeuaiiy eaeueoeeoii?io a e?ia? ? aene?aoe?? eaeueoe?th. ?iceaaee a iaoaaie?ci? NO ia?inoaee c aeoeai?noth, iioe?ai?noth,o?eaae?noth iaoieia?/iiai i?ioeano. Io?eiai? aeai? i?i a?aei?iiino? o ae?aaeaiino? noaeiaiaiai neiae?iio, aeoeaiino? iaoieia?/iiai i?ioeano, /anoio? ?aoeeaeea?a, oaiiao i?ia?anoaaiiy ci?i a noaeiaao ? a?noea?aeueieo o?aaeaiue na?ae/eee ia ei?enoue aaoa?iaaiiino? aa??aio?a noaeiaiai? ? noaeiaiai-a?noea?aeueii? oi?i TH?A. Ia?aaeon?i oea a?aeiineoueny aei noaeiaiai? oi?ie iiiiie?ai- ? iie?a?oeeoey?iiai TH?A. Anoaiiaeaii, ui oneeaaeiaiiy a ae?aaiinoeoe? aie?eicoth/iai niiiaeeeia?o?eoo a ia?o? ?iee oai?iae aoee iaoiiaeai? i?ciueith iiyaith oeiiaeo iciae o?aaeaiiy inueiaiai neaeaoa, nae?i?eaaeueieo c/eaioaaiue ? ia?aaaaeaiiyi o i?aee?oe?a ia?eoa?e/ii? oi?ie AN c iiiiie?aia?o?eoaie, iii??ii ae?aaeaieie aenoaeaoeaieie i?iyaaie ? /anoeie ?aoeeaeeaaie noaeiaiaiai neiae?iio. Ia a?aei?io a?ae TH?A, o /anoeie i?aee?oe?a, oai?eo ia AN (17,4 % ), aaea c ii/aoeo oai?iae niinoa??aaeiny o?aaeaiiy oacinoaaiiaeo noaeia?a, yea ia e?iaoeue ?ieo iaei i?noea o 34,5% thiae?a. Oa?aeoa?iei neiioiiii AN aoea iiyaa aioaciiao?e, ?aii?e ?icaeoie i?io?io?e, ia?aaeon?i a cii? o?aaeaieo noaeia?a. Aeyaeaii a?aenooi?noue ia?aeae?cio i?ae iiyaith ee?i?/ieo ? ?aioaaiieia?/ieo iciae, iniaeeai a cii? e?eaeiai-eeoaiaeo c/eaioaaiue. I?e iinoaiiaoe? ae?aaiico AN o i?aee?oe?a c a?o?eoii ieaei?o e?ioe?aie aaaeeeaa ae?aaiinoe/ia cia/aiiy iaee cia/i? a?aeoeeaiiy a ??ai? iieaciee?a OCA, na?iioei?aeo, ae?eii?ioa?ae?a, n?aeiaeo eeneio, ia a?aeiia?aei? iii??i?e ae?aaeaiino? ee?i?/ieo i?iya?a noaeiaiaiai neiae?iio. AN oa?aeoa?ecoaaany noiaeeie c TH?A ii?ooaiiyie a O- ? A nenoaiao ?ioi?oaoo, ?icaeoeii aaoi?ioiiiai caiaeaiiy. O oie aea /an o a?eueoino? oai?eo ia AN /ano?oa aecia/aany i?aeaeuaiee ??aaiue Oe?E ( 70,0 % ), cieaeaiiy ai?noo IgG ( 60,0 % ), eiiieaiaioo (80,0%). Aeacaia aeicaieyei i?eioneaoe iaiaeiaeiaee neeaae Oe?E i?e TH?A ? AN ? a?eueo /anoa aeeth/aiiy IgG a Oe?E o oai?eo ia AN, ui iiaei aieeaaoe ia oa?aeoa? ? oaiie ooeiaeaeaiiy iii?ii-?ooiaiai aia?aoo. AN a?ae??ciyany cia/ieie ? ??ciinoi?iii?ie a?aeoeeaiiyie a iai?i? niieo/ii-oeaieiieo no?oeoo?, ui iineee eaoaaie?/iee oa?aeoa? ? i?iyaeyeeny i?aeaeuaiiyi o a?eueoino? oai?eo aene?aoe?? ienei?ie?io (55,6%) ? noia?ieo AAA (68,9% ). C?inoaiiy iieaciee?a noia?ieo AAA a?aeaoaaeiny ca ?aooiie oiiae?i?oei-6-noeueoao?a ? aea?iaoainoeueoao?a, i?e cieaeaiiio ai?no? ?ioeo o?aeoe?e. E??i oiai, niinoa??aaeany ae?aaeaia aeoeaaoe?y oa?iaio?a, ye? aa?ooue o/anoue a eaoaaie?/ieo i?ioeanao - eenei? ? eoaeii? oinoaoac. AN oa?aeoa?ecoaaany oaeiae iniaeeainoyie a eaeueoe??aiio iai?i?, ye? i?iyaeyeeny cia/iei i?aeaeuaiiyi eaeueoeeoii?io i?e ii?iaeueieo iieacieeao aene?aoe?? eaeueoe?th, ui aeicaieyei aeoiaoe i?i i?ia?ae?caoe?th oeaiei, yea a i?ioean? iiaeaeueoiai niinoa?aaeaiiy i?aeoaa?aeaeoaaeany aeaieie ?aioaaiieia?/iiai aeine?aeaeaiiy. I?ia?anoaaiiy ee?i?/ii? neiioiiaoeee ?c ca?eueoaiiyi o?eaaeino? caoai?thaaiiy noi?iaiaeaeoaaeiny ia?inoaiiyi ii?ooaiue a iaoaaie?ci? NO: a?aeaoaaany a?eueo aeeaieee ia?a?iciiae?e o?aeoe?eiiai neeaaeo AAA, ca?eueoaiiy ienei?ie?io??? ? aeoeaiino? aeacaieo oa?iaio?a. A?aeia?aaeaiiyi aeoeaiino? caiaeueiiai i?ioeano i?e AN aoee ii?ooaiiy a i?e?ioee?eoeyoi?iiio ?one?, ye? iineee ??ciinoi?iii?e oa?aeoa? ? iaee ae?aaiinoe/ia cia/aiiy, ine?eueee aaea c ia?oeo ?ie?a oai?iae o a?eueoino? i?aee?oe?a c'yaeyeeny noaeeii? (100,0%), aioo??oiueinoaeeii? (88,9%) ? ia?eaaneoey?i? (44,4%) ci?ie. Oaeei /eiii, no/aniee AN ia ii/aoeiaeo aoaiao ?icaeoeo a i?aee?oeiaiio a?oe? a?ae??ciy?oueny a?ae i?iya?a o aei?ineeo iaeineiioiii?noth aai a?aenooi?noth oeiiaeo iciae o?aaeaiiy inueiaiai neaeaoa, ia?aaaaeaiiyi ia?eoa?e/ieo a?o?eo?a, oa?aeoa?eco?oueny ?aii?ie ? aeeaieeie i?e?ioee?eoeyoi?ieie ?iceaaeaie a ii?aeiaii? c aenieith eaai?aoi?iith aeoeai?noth, cia/ieie ii?ooaiiyie iaoaaie?cio eieaaaio ? i?ioaiae?eai?a. Aeyaeai? a?aeoeeaiiy ? a?aei?iiino? ??aiy noaoaaeo noa?i?ae?a o oai?eo ia OA aeacoaaee ia ?o a??ia?aeio cia/ou?noue a oa?aeoa?? e iniaeeainoyo ?ioiieia?/ieo ?iceaae?a (Ahmed S.A. et al, 1985), ui aecia/aei nai???aei?noue ee?i?/ii? neiioiiaoeee o i?aee?oe?a ia aoaiao noaoaaiai aeic??aaiiy ? aaiethoe?th caoai?thaaiue caaaeii. Anoaiiaeaii, ui i?e THOA ? ?aA a?aei?/aeiny a ??ai?e i??? i?aeaeuaiiy ano?aae?ieo (a?aeiia?aeii: 29,0% ? 34,4%), cieaeaiiy oanoinoa?iio aai ano?aae?ieo (a?aeiia?aeii: 27,4% ? 33,8%; 19, 5% ? 28,7%). I?e TH?A o a?eueoino? oai?eo niinoa??aaeiny ciaioaiiy ai?noo oanoinoa?iio (69,5%) ? noiae? ca /anoioith c THOA ? ?aA ci?ie a ??ai? ano?aae?ieo. Oea aeicaieyei i?eioneaoe ??cio i??o o/ano? ano?aae?ieo ? oanoinoa?iio a iaoiaaiaoe/ieo iaoai?ciao ie?aieo iicieia?/ieo oi?i. Aeai? aaiaoe/iiai aiae?co aeicaieeee ia o?eueee a?aeianoe THOA ? ?aA aei caoai?thaaiue c niaaeeiaith noeeuei?noth, aea e io?eiaoe aeieace ia ei?enoue iie?aaiiiai oeio oniaaeeoaaiiy. I?aeoaa?aeaeaiiyi oeueiio aoea a?aenooi?noue c aenieei nooiaiai aeinoia??iino? ( ? < 0,001 ) a?aeiia?aeiino? oaeoe/iiai ?iciiae?eo oai?eo na?aae ?iaee/?a i?iaaiae?a i?e iaio oeiao oethao oai?aoe/ii i/?eoaaiiio ye aeey aeii?iaioii?, oae ? ?aoeaneaii? iiaeae? oniaaeeoaaiiy. Anoaiiaeaii aenieo a??ia?aei?noue iiaoi?aiiy aea/aieo caoai?thaaiue a n?i'? i?e iayaiino? oai?iai neana ?, iniaeeai, aaouee?a. Aeyaeaii anioe?aoe?? OA ? aaiaoe/ieo ia?ea??a. Aecia/aii noaoenoe/ii aeinoia??i? anioe?aoeai? ca'ycee i?ae aioeaaiaie HLA ? caoai?thaaiiyie, a oaeiae aa??aioaie ?o ia?aa?ao. Ia?ea?ii THOA ? aioeaaie A3, A28, A40; ?aA - A10, A8; TH?A - A27, A40. Ia?ea?ii ?aoeeaeeaoth/iai ia?aa?ao i?e ?aA aoa aaieioei N3,4. Oai?? ia THOA, ?aA, TH?A ? AN iaee ?noioi?, a ii??aiyii? ?c caei?iaeie, a?aei?iiino? (? < 0,01 0,001) a e?euee?nieo ? ye?nieo aea?iaoiae?o?/ieo iieacieeao, a oaeiae a?aei?oi? iciaee i?ae caoai?thaaiiyie. Cacia/aii ciaioaiiy iaeeo iaoaeue ia III iiaeooa/oe? i?e THOA ? oeueia?ieo aeoa ia a?iioaia?? i?e ?aA. Caaaeii, i?e OA anoaiiaeaii ca?aeithaaiiy ?enoiea ia iaeueoeyo. ?acoeueoaoe ee?i?/ieo niinoa?aaeaiue, aaiaaeia?/iiai aiae?co, iayai?noue niaoeeo?/ieo aaiaoe/ieo ia?ea??a aeicaieythoue c aeinoaoiueith ia?aeiieea?noth ?icaeyaeaoe THOA ie?aiith, aaiaoe/ii aeaoa?i?iiaaiith iicieia?/iith oi?iith. Io?eiai? aeai? i?aeoaa?aeaeothoueny ? ?acoeueoaoaie noi?nieo aeine?aeaeaiue c ?.I. E?eae/ ? I.A.Aaaaoeueeith [1994] ii aea/aiith aaiaoe/ii aeaoa?i?iiaaiiai iniiaiiai no?oeoo?iiai N-aaoa?io?iiaoeio o?iiinii, ui aeyaeee a?aei?iiino? i?e THOA ? TH?A o aa??aaaeueiino? aaoa?io?iiaoeio aiiieia?a 9 (9’ ?< 0,01) ? 16 o?iiinii ( 16’’ ?< 0,001), a oaeiae o a?aeiinieo ?ici??ao o?iiinii 1 ( ?< 0,001), 9 (?< 0,001), 16 ( ?< 0,001) e ?o aiiieiaao (1’ - ? <0,001; 1” - ? <0,001; 9’ - ?< 0,01; 16” - ?< 0,001). Oea na?ae/eei i?i aaiaoe/io iaiaeii??aei?noue iaio caoai?thaaiue. C iaoith ooi/iaiiy iaoai?ci?a ?icaeoeo o?ii?/ieo a?o?eo?a i?iaaaeaiee ei?aeyoe?eiee aiae?c, yeee aeicaieea anoaiiaeoe i?e THOA, ?aA ? TH?A noaoenoe/ii aeinoia??i? ei?aeyoeai? ca'ycee i?ae ie?aieie iieacieeaie ?ioi?oaoo, niieo/ii-oeaieiieo no?oeoo?, noaoaaeie noa?i?aeaie, e?ciniiaeueieie, oeeoie?oe/ieie oa?iaioaie, aaiaoe/ieie ia?ea?aie. Iacaaaeath/e ia aeyaeai? ia o?eueee noiae? oaiaeaioe??, aea e a?aei?iiino? o aca?iia?aeiineiao i?ae iieacieeaie, aecia/eoe iniaeeaino? a iaoai?ciao oi?ioaaiiy eiaeiiai caoai?thaaiiy ia iniia? ei?aeyoe?eiiai aiae?co ia aaeaeiny. Aeey ooi/iaiiy no?oeoo?e caeaaeiino? i?ae iieacieeaie e ??cieie nenoaiaie i?aai?cio e aeyaeaiiy i?eoiaaieo ca ci?iieie iaoai?ci?a ? yaeu, ui ia caaaeaee i?aeaeathoueny aei??thaaiith, canoiniaaiee aaaaoii??iee noaoenoe/iee aiae?c - oaeoi?iee aiae?c ( iaoiaeii aieiaieo eiiiiiaio). Anoaiiaeaii, ui i?e THOA ia? i?noea aeoeaia aeeth/aiiy ee?oeiii? ? aoii?aeueii? eaiee ?ioi?oaoo a ?ioiiiaoieia?/i? ?aaeoe?? (a?aeia?aaeai? a eiaeiiio c /ioe?ueio oaeoi??a - F), ia oa?aeoa? ae?aaeaiino? yeeo aieeaa? ano?aae?ie (F1), ( ?enoiie ). O oie aea /an, ooieoe?iiaeueiee ca'ycie i?ae ?ioiiith nenoaiith ? oanoinoa?iiii, ca aeaieie F4, na?ae/ea i?i iacia/ia cieaeaiiy eiai ?ioiinoi?aneaiiai aoaeoo. Nenoaia aca?iica'yce?a iieaciee?a (F1 ? F3) aeacoaaea ia oa, ui ia aoaiao ?aae?caoe?? ?ioiiiaoieia?/ieo i?ioean?a a?aeaoaathoueny ii?ooaiiy a iaoaaie?ci? niieo/ii-oeaieiieo no?oeoo?, a a?eueo?e i??? - i?ioaiae?eai?a. I?e oeueiio, ?noioia cia/aiiy a ?icaeoeo eaoaaie?/ieo i?ioean?a a no?oeoo?ao i?ioaiae?eai?a ia? aeoeaaoe?y eenei? oinoaoace, eieaaaio - eoaeii? oinoaoace. ?ieue aaiaoe/ieo oaeoi??a i?e aeaiiio caoai?thaaii? a?aeia?aaeaa F2. Aeyaeaii iaaio noiae?noue a iaoai?ciao ?icaeoeo THOA ? ?aA, a oiio /ene? cia/ouino? ?ioiiiaoieia?/ieo i?ioean?a ( F1 - F4 ) ? ano?aae?ieo a ?o ?aae?caoe?? (F1). Anoaiiaeaii, ui eaoaaie?/i? i?ioeane a niieo/ii-oeaieiieo no?oeoo?ao iathoue i?e ?aA aaciina?aaei?e ca'ycie c aeoeai?noth a aoii?aeuei?e eaioe? ?ioi?oaoo ? e?ciniiaeueieie oa?iaioaie (F2). Ia o/anoue aaiaoe/ieo oaeoi??a a ?icaeoo ?aA aeacoaaee aca?iica'ycee iieaciee?a a F2, F4. Aeai? oaeoi?iiai aiae?co na?ae/eee i?i oa, ui i?e TH?A ia oa?aeoa? ?ioiiiaoieia?/ieo ?aaeoe?e aeoeaii aieeaa? ye ano?aae?ie (F2), oae ? oanoinoa?ii (F1). Ii ??aith oaeoi?ieo aiane?a ? aeenia?n?? F1 oanoinoa?ii a ?icaeoeo TH?A a?aa ?noioii a?eueoo ?ieue, i?ae i?e THOA ? ?aA. Oea a?aeiineeiny oaeiae aei Oe?E ? aioeo?e aei AeIE ( F1, F2). Aca?iica'ycie aeoeaaoe?? aoii?aeueii? eaiee ?ioi?oaoo ? eenei? oinoaoace a ii?ooaiiyo iaoaaie?cio i?ioaiae?eai?a (F3), eoaeii? oinoaoace ? iaoaaie?cio eieaaaio (F4) aoa noiaeee c THOA. Aianie aaiaoe/ieo oaeoi??a a ?icaeoie TH?A a?aeia?aaeaee F2, F4. A i?ioean? ooi/iaiiy noiaeeo iaoai?ci?a ?icaeoeo ? anoaiiaeaiiy iniaeeainoae oi?ioaaiiy eiaeii? iicieia?/ii? oi?ie noai?aia ni?eueia oaeoi?ia iiaeaeue aeey THOA ? TH?A. Aeyaeaii oa?aeoa?i? aeey iaio caoai?thaaiue iaoai?cie: ii?ooaiiy iaoaaie?cio eieaaaio ca o/anoth eoaeii? oinoaoace (F1), ca'ycie ci?i iai?io i?ioaiae?eai?a c aeoeaaoe??th i?ioean?a a aoii?aeuei?e eaioe? ?ioi?oaoo (F2 ? F3 ) ? aieea ano?aae?ieo ia O-e?ioioeeoe (F4). ?acii c oei, io?eiaii ? aeniei aeinoia??i? a?aei?iiino? ( e?eoa??e O?oi?- A?eeieniia) ii F2 (?<0,01), F3 (?< 0,001) ? F4 (?<0,05) ? aeinoia??ia ca?eueoaiiy F2, F3 ? F4 (?>
0,01 0,001) i?e TH?A, a ii??aiyii? c THOA. Oea aeaco? ia oa, ui i?e
TH?A niinoa??aa?oueny a?eueo o?nia aca?iiae?y i?ae aoii?aeueieie
oaeoi?aie ?ioi?oaoo ? i?ioaiae?eaiaie, a oaeiae ano?aae?ieii ?
O-e?ioioeeoaie. Inoaii?, i/aaeaeii, iineeth? aeenaaeain
?ioiieiiiaoaioieo ee?oei, aeiaea? ?ioiiiaoieia?/iei i?ioeanai a?eueo
aa?aneaiee oa?aeoa? noiniaii aieeao ia no?oeoo?e NO. O ?icaeoeo THOA ?
?aA, ca aeaieie ni?eueii? oaeoi?ii? iiaeae?, niinoa??aaeany noiae?noue a
i?ioeanao ii?ooaiiy iaoaaie?cio eieaaaio ia oii? i?aeaeuaiiai
aioeo?eiooai?thaaiiy ? aeoeaaoe?? eoaeii? oinoaoace (F1), o/ano?
ano?aae?ieo a aeoeaaoe?? A-eaiee ?ioi?oaoo (F2), ?icaeoeo eaoaaie?/ieo
i?ioean?a ia ??ai? i?ioaiae?eai?a e ?o ca’ycie c aeoeai?noth
aoii?aeueii? eaiee ?ioi?oaoo (F3). ?acii c oei, ii F1 ? F3 aeyaeaii
?noioi? noaoenoe/i? a?aei?iiino? (?<0,05-0,001), ui aeacoaaei ia a?eueo aeeaie? ii?ooaiiy a nenoaiao ?ioi?oaoo, iaoaaie?ci? eieaaaio ? i?ioaiae?eai?a i?e THOA. Acaaae?, aeai? oaeoi?iiai aiae?co aca?iica'yce?a iieaciee?a, ui aeicaieythoue ?icaeyaeaoe iniaeeaino? a iaoai?ciao ?icaeoeo THOA, ?aA, TH?A e ?o a?aei?iiino?, iiaeathoue ia?aeiieeao ?ioi?iaoe?th ia ei?enoue naiino?eiino? ye ie?aii? iicieia?/ii? oi?ie THOA. I?iaaaeai? aeine?aeaeaiiy aeicaieeee iiaoaeoaaoe oaeo eiioeaioe?th ?icaeoeo THOA: a iniia? iaoiaaiaoe/ieo i?ioean?a i?e aeaiiio caoai?thaaii? eaaeaoue ?ioiiiaoieia?/i? iaoai?cie, aaoi?ioiia caiaeaiiy c aeenaaeainii ?ioiieiiiaoaioieo ee?oei, cieaeaiiyi O-e?ioioeeo?a, oaio?e?i/ooeeaeo e?ioioeeo?a (noi?ani??a), iineeaiiyi aeoeaaoe?? A-e?ioioeeo?a, ia nooi?iue ae?aaeaiino? yei? aieeaa? ano?aae?ie. O /anoeie oai?eo oea a?aeaoaa?oueny ia oii? ca?eueoaiiai ai?noo ai?iiio. O ?ac? cieaeaieo aai ii?iaeueieo iieaciee?a ano?aae?ieo, i/aaeaeii, ia? cia/aiiy i?aeaeuaiiy ??aiy ano?iaaiiaeo ?aoeaioi??a ia iiiiioeeaa?ao (Iiae/a?iyaaa I.N. n niaao, 1998). Ia a?aei?io a?ae TH?A, a ?icaeoeo THOA c o?aooaaiiyi aeaieo aeenia?n?? oaeoi??a ?ieue oanoinoa?iio iaio cia/oua, i?ae ano?aae?ieo ?, iaaooue, iaei ii?ooo?oueny eiai ?ioiinoi?aneaiee iaoai?ci, ui ciaioo? aoaeo iineeaiiy ano?aae?ieii aioeo?eiooai?thaaiiy. ?icaeoie eaoaaie?/ieo i?ioean?a ia ??ai? i?ioaiae?eai?a ? eieaaaio i?e THOA ia? ca'ycie c? nooiaiai ae?aaeaiino? ii?ooaiue o aoii?aeuei?e eaioe? ?ioi?oaoo, aeoeai?noth e?ciniiaeueieo oa?iaio?a, eoaeii? oinoaoace ? eiio?ieth?oueny ano?aae?ieii ca aeiiiiiaith iiaea?eiiai aieeao: aeuacaaaeaiiai /a?ac ee?oeii? oaeoi?e ?ioi?oaoo ? aaciina?aaeiuei ia o?ceei-o?i?/i? ? ooieoe?iiaeueii-ii?oieia?/i? aeanoeaino? i?ioaiae?eai?a (Peavonen T., 1987). Iii??iee oa?aeoa? ?ioiiiaoieia?/ieo cnoa?a i?e THOA ciaioo? cia/ou?noue o/ano? e?ciniiaeueieo oa?iaio?a ? eoaeii? oinoaoace a i?ioeanao aeano?oeoe?? oeaiei ? aecia/a? ni?eyoeea? iane?aeee caoai?thaaiiy. Eiiieaeniee aiae?c ee?i?/ii? neiioiiaoeee o?ii?/ieo a?o?eo?a ia ??cieo aoaiao ?o aaiethoe??, aeyaeai? caeiiii??iino? c aieo iieaciee?a ?ioiiaaiaco, iai?io NO, aea?iaoiae?oe/ieo ia?aiao??a aeicaieeee io?eiaoe aeinoia??io ?ioi?iaoe?th i?i nooi?iue a?aei?iiinoae i?ae ON, ui aea/athoueny, ? ca aeiiiiiaith nenoaiii-?ioi?iaoe?eiiai aiae?co, iaoaiaoe/iiai i?aeoiaeo Aaeueaea ?ic?iaeoe aeeoa?aioe?aeueii-ae?aaiinoe/i? aeai?eoie aeey o?ii?/ieo a?o?eo?a caaaeii (THOA, TH?A, ?aA ? AN ) ? ie?aii aeey noaeiaiai? oi?ie TH?A ? THOA, ?aA ? THOA, a oaeiae aeai?eoie i?iaiico iaio ni?eyoeeaiai ia?aa?ao ?aA ? THOA. O i?iaiic? /anoi ?aoeeaeeaoth/iai ia?aa?ao THOA iaea?eueo cia/oueie iciaeaie ?: iayai?noue ?aoeeaeea?a a?o?eoo ia ia?oiio ?ioe? oai?iae, o?eaae?noue iiaoi?ieo a?o?eo?a a?eueoa aeaio i?nyoe?a, i?aeaeuaiiy iieaciee?a IgM, cieaeaiiy eiiieaiaioo, a?aenooi?noue iiaiiai cai?ioiiai ?icaeoeo a?o?eoo ? i?e?aeiaiiy o?aaeaiue ?ioeo noaeia?a ia e?iaoeue ia?oiai ?ieo oai?iae. Aeey ?aoeeaeeaoth/iai ia?aa?ao ?aA aenieo ?ioi?iaoeaio cia/ou?noue iaea iayai?noue o?ii?/ieo aiaieu ?ioaeoe??, a?o?eoo e?eoueiaeo noaeia?a, a?eueoa o?ueio noaeia?a c aenoaeaoii, i?aei'yoeiaiai ao?neoo, o?eaae?noue a?o?eoo a?eueo 1,5 i?nyoe?a, ?aoeeaeeae ia ia?oiio ?ioe? oai?iae. Aei?iaoaaiiy ?ic?iaeaieo aeai?eoi?a aeicaieeei o 86,4% aeiaaee?a aecia/eoe iicieia?/io iaeaaei?noue aaea ia ?aii?o aoaiao ?icaeoeo caoai?thaaiiy, a i?e THOA ? ?aA aei e?ioey ia?oiai ?ieo iaoieia?/iiai i?ioeano - oa?aeoa? eiai aaiethoe?? ? na?ae/eei i?i aeioe?euei?noue ?o aeei?enoaiiy a i?aeoeoe?. Aeyaeai? cia/i? ? no?ee? ii?ooaiiy a iaoaaie?ci? niieo/ii-oeaieiieo no?oeoo?, i?e?ioee?eoeyoe??, ?ioii?e nenoai? i?e OA ??cii? i?e?iaee e ?o iniaeeaino? i?e eiaei?e iicieia?/i?e oi?i? aecia/eee iniiai? i?eioeeie ?aaa?e?oaoe?? i?aee?oe?a: aoaii?noue ( noaoe?iia? - iie?ee?i?ea - naiaoi??e) e ?iaeea?aeoaeuei?noue. I?e ?ic?iaoe? noai ? eiiieaen?a oa?ai?? a?aoiaoaaany oa?aeoa? ee?i?/ieo i?iya?a, aeoeai?noue caiaeueiiai i?ioeano, nooi?iue o?aaeaiiy noaeiaiaiai aia?aoo ? eiai i?ia?anoaaiiy. A?aeiiaia e?eoaaiiy o?ii?/ieo ia?aaiaoi?aeieo a?o?eo?a aeeth/aei iaaeeeaiaioici? ? iaiaaeeeaiaioici? iaoiaee. Ia an?o aoaiao ?aaa?e?oaoe?? aeei?enoiaoaaeeny caniae ? iaoiaee, ni?yiiaai? ia oia?aaeaeaiiy ? ai?ioueao ?c caiaeueii-aeano?oeoeaieie ci?iaie ? aeoeaaoe?th i?e?iaeieo iaoai?ci?a aeaeoaeaiiy. Ia noaoe?iia?iiio aoai? i?iaiaeeany i?aea?? iioeiaeueieo ii ae?? e?ea?nueeeo cania?a, a oaeiae iaoiae?a o?ce/ii? ?aaa?e?oaoe?? ? i?noeaaiai e?eoaaiiy. O oai?eo ia THOA i?e iayaiino? aeoeaiiai caiaeueiiai i?ioeano iniiaia i?noea caeiaee ianoa?i?aei? i?ioecaiaeuei? i?aia?aoe (IICI), ye? i?ecia/aeeny ia aanue ia??iae caiaeueieo ci?i a noaeiaao ? i?ioyaii ianooiieo 1,5 - 3 i?nyoe?a a iieiaeii?e aeic?, a?aoiaoth/e aeyaeaio i?e ianoaii? ?ai?n?? oaiaeaioe?th aei caa??aaiiy ci?i a O- A- nenoaiao ?ioi?oaoo, no?eeeo i?e?ioee?eoeyoi?ieo ?iceaaeao (oaaeeoey), (eiiieaen ?1). I?e o?eaaeiio a?o?eo? a?eueo 2,5-3 i?nyoe?a ? a?aeoeeaiiyo, ui caa??aaeeny a ee?oeii?e aai aoii?aeuei?e eaioe? ?ioi?oaoo, aei e?eoaaiiy IICI i?e?aeioaaeeny aaceni? caniae (aeaeaa?e, ieaeaai?e, naeaciie?eaeacei), o?eaae?noue canoinoaaiiy yeeo neeaaeaea a?ae 6 i?nyoe?a aei ?ieo (eiiieaen ?3). Iiyaa yne?aai ae?aaeaieo aenoaeaoeaieo i?iya?a a noaeiaao aecia/aea iaiao?aei?noue iineeaiiy i?ioecaiaeueii? oa?ai?? i?ecia/aiiyi aioo??oiueinoaeiaiaiai aaaaeaiiy i?aia?ao?a - eaiaeiaa, eaiaeiaa+oeeeeioinoai?aea, ae?i?iniaia (eiiieaen ?2). Ia aeaiiio aoai? ?aaa?e?oaoe?? aecia/aeeny oaeiae i?aeoiaee ? iaoiaee uiaei i?noeaai? oa?ai?? c aeei?enoaiiyi o?c?ioa?aiaaoe/ieo i?ioeaaeo? (iaai?oieaca?ii? oa?ai??, aeaeo?iioieoo?e ), iaoaiioa?ai??, e?eoaaeueii? o?ceoeueoo?e, ianaaeo. I?e ?aA i?iaiaeeeany ao?io?iiia oa?ai?y c i?ecia/aiiyi aioea?ioee?a, ia?aaaaeii ae?? oe?ieiai niaeo?a -oao?aoeeee?iiaiai ?yaeo. O oai?eo ?c oeai?ae?eiith ?ioaeoe??th e?eoaaiiy aeeth/aei a?eo?ii?oeei, eaaii?oeaoei, ???nei?iciith - aaioai?oeei, eaaii?oeaoei. Aioeaaeoa??aeueia oa?ai?y, eo?n yei? noaiiaea 3-4 oeaei?, i?ecia/aeany ia oii? i?ioecaiaeueiiai e?eoaaiiy IICI, ye? canoiniaoaaeeny, ye ? i?e THOA, i?ioyaii anueiai ia??iaeo aeoeaiiai a?o?eoo, a o oai?eo c ?aoeeaeeaoth/eie aa??aioaie ia?aa?ao, no?eeeie ci?iaie a iieacieeao i?e?ioee?eoeyoe??, ?ioiiaaiaco - aei aeaio i?nyoe?a a iieiaeii?e aeic? i?ney auooaiiy caiaeueieo ci?i (eiiieaen ?4). I?e ?aA i?eioeeie aioo??oiueinoaeiaiaiai i?ecia/aiiy ? aaaaeaiiy i?aia?ao?a, canoinoaaiiy iaiaaeeeaiaioicieo iaoiae?a aoee ?aeaioe/ieie c THOA (eiiieaen ?5). E?eoaaiiy i?aee?oe?a, oai?eo ia TH?A, aoei aeeoa?aioe?eiaaiei, /?oei a?aoiaoaaeany oi?ia, aa??aio ia?aa?ao i?ioeano, eiai aeoeai?noue, iayai?noue a?noea?eo?a. A?naiae iaaeeeaiaioicieo i?aia?ao?a i?e noaeiaia?e oi?i? TH?A aoa noiaeei c THOA. Iaeiae o?eaae?noue aeei?enoaiiy IICI o ca’yceo ?c cia/ieie ii?ooaiiyie, ui caa??aathoueny a ?ioiieia?/iiio aiiainoac?, ia?aaaaeaii? ae?aaeaieo eaoaaie?/ieo i?ioean?a , ia??aeei neeaaeaea i?nyoe?, a aacenieo cania?a (aeaeaa?eo, ieaeaai?eo) - aeae?eueea ?ie?a, iniaeeai, i?e iie?a?oeeoey?ieo aa??aioao, oaeaeeiio i?ia?anoaaii? i?ioeano (eiiieaen ?6). O oai?eo ia TH?A c ?icaeoeii a?noea?eo?a ia oii? aeeaieiai aeenaaeaino ?ioiieiiiaoaioieo ee?oei, aeoeaaoe?? aoii?aeueii? eaiee ?ioi?oaoo aei oa?ai?? i?e?aeioaaeeny aetheiei?oeei?aee, ia?aaaaeii i?aaei?cieii, aeice yeiai caeaaeaee, ianaiia?aae, a?ae aeoeaiino? caoai?thaaiiy ? oa?aeoa?o eiai i?ia?anoaaiiy (eiiieaen ? 7). O ?ac? oyaeeeo, i?ia?anoth/eo aa??aio?a ? a?aenooiino? aoaeoo a?ae aeacaieo iaaeeeaiaioicieo cania?a aeei?enoiaoaaeeny ?ioiiaeai?anaioe - acao?ii??i, iaoao?aenao ( eiiieaen ?8). I?e oyaeeiio, oi?i?aeiiio ia?aa?ao TH?A oai?ei i?ecia/aeeny i?aia?aoe oeiona. Iaoiaee o?ce/ii? ? nioe?aeueii? ?aaa?e?oaoe?? i?e TH?A aeei?enoiaoaaeeny c o?aooaaiiyi ?ic?iaie A.I.Eieii??oeue [1992] ii ?o canoinoaaiith. I?e ia?eoa?e/i?e oi?i? AN o?eaaei, ia??aeei ?ieaie canoiniaoaaeeny IICI. I?aia?aoii aeai?o aoa ?iaeiiaoaoeei (eiiieaen ?1). O ?ac? ?icaeoeo a?noea?aeueieo o?aaeaiue i?ecia/aeeny, ye ? i?e TH?A, eiiieaene ?? 6-7. O oai?eo ia AN oe?iei aeei?enoiaoaaeeny o?ce/i? iaoiaee ?aaa?e?oaoe??, ye? aeeth/aee EOE, ianaae, aeaeo?iioieoo?o, iaai?oieaca?ioa?ai?th. Aeey ioe?iee aoaeoeaiino? aoa ?ic?iaeaiee aeai?eoi ?c aeeth/aiiyi ee?i?/ieo ( i?eiooe?noue noaeia?a, noaeiaiaee neiae?ii ??/e, neiioii “a?/iiai noeniaiiy eeno?”, /enei aeoeaieo noaeia?a, ?aieiaa neoo?noue ), a oaeiae a?io?i?/ieo e ?ioiieia?/ieo iieaciee?a, ui oa?aeoa?ecothoue aeoeai?noue caiaeueiiai i?ioeano. Io?eiaii iiceoeai? ?acoeueoaoe o an?o oai?eo ia ?aA ? THOA ? o a?eueoino? i?aee?oe?a, oai?eo ia TH?A (89,6%). A?aoiaoth/e, ui o oai?eo ia OA ci?ie a nenoaiao ?ioi?oaoo, iaoaaie?ci? NO niinoa??aaeeny iaa?oue i?e ianoaii? ee?i?/ii? ?ai?n??, ia iie?ee?i?/iiio aoai? ?aaa?e?oaoe?? ia oii? ciaioaiiy iciae a?o?eoo ? caaaeueii? caiaeueii? aeoeaiino? caa??aaeeny iniiai? i?eioeeie i?ecia/aiiy ?ic?iaeaieo eiiieaen?a e?eoaaiiy, aea ciaiooaaeeny aeice i?ioecaiaeueieo i?aia?ao?a aei i?aeo?eioth/eo, ?icoe?yany ae?aiacii o?c?ioa?aiaaoe/ieo i?ioeaaeo?, o?eaaei aaeeaaiiy aacenieo i?aia?ao?a a iaaeao aeacaieo aeua no?ie?a. I?e aeinyaiaii? ee?i?ei-eaai?aoi?ii? ?ai?n?? oai?? i?iaeiaaeoaaee e?eoaaiiy ia naiaoi?ii-eo?i?oiiio aoai?, aea a caeaaeiino? a?ae iicieia?/ii? oi?ie ? ee?i?ei-iaoiaaiaoe/ieo iniaeeainoae caoai?thaaiiy, ooieoe?iiaeueiiai noaio i?aai?a aeei?enoiaoaaeeny i?e?iaei? e?eoaaeuei? /eiieee ( ee?iaoie?eoaaiiy, aeaeoioi?ac a?yc?, a?ycueia? aie?eaoe??, aaeueiaie?eoaaiiy), i?iaiaeeeany o?ce/ia ?ic?iaea noaeia?a, EOE, iaoaiioa?ai?y, a oaeiae i?iaeiaaeoaaeiny aeei?enoaiiy i?ioecaiaeueieo ? aacenieo cania?a o oai?eo ?c caiaeueieie ci?iaie a noaeiaao ? ii?ooaiiyie a iieacieeao ?ioi?oaoo. ?ic?iaeaii i?eioeeie aeeniaina?iiai niinoa?aaeaiiy oai?eo ia THOA, ?aA, aianaii ei?aeoeae a iueiai aeey i?aee?oe?a, oai?eo ia TH?A ? AN c o?aooaaiiyi aeoeaiino? i?ioeano, /anoioe ?aoeeaeea?a, oa?aeoa?o i?ia?anoaaiiy. Oaaeeoey – Aeeoa?aioe?eiaai? eiiieaene e?eoaaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe Iicieia?/ia oi?ia, aa??aio ia?aa?ao E?eoaaeueiee eiiieaen THOA, iiiiie?aia?o?eo, 1-2 nooi?iue aeoeaiino?IICI, EOE, ianaae, iaoaiioa?ai?y, iaai?oieaca?ia oa?ai?y (eiiieaen ?1)THOA, iiiiie?aia?o?eo, 1-2 nooi. aeoeaiino?, ae?aaeaiee aenoaeaoeaiee eiiiiiaio caiaeaiiyIICI, aioo??oiueinoaeiaiaa aaaaeaiiy i?aia?ao?a, ianaae, iaoaiioa?ai?y, iaai?oieaca?ia oa?ai?y (eiiieaen ?2)THOA. iiiiie?ai-iie?a?o?eo, /anoi ?aoeeaeeaoth/ee ia?aa?aIICI, aaceni? caniae (o?iie?iia?, noeueoanaeacei), aioo??oiueinoaeiaiaa aaaaeaiiy i?aia?ao?a, ianaae, iaoaii-, iaai?oieaca?ia oa?ai?y (eiiieaen ?3)?aA, 1-2 nooi?iue aeoeaiino?IICI. Aioea?ioeee, EOE, ianaae, iaai?oieaca?ia oa?ai?y (eiiieaen ?4)?aA, noaeiaiaee neiae?ii c yne?aai ae?aaeaiei aenoaeaoeaiei eiiiiiaioiiIICI, aioea?ioeee, aioo??oiueinoae. Aaaaeaiiy i?aia?ao?a, EOE, ianaae, iaai?oieaca?ia oa?ai?y (eiiieaen ?5)TH?A, noaeiaiaa oi?ia, iia?eueii i?ia?anoth/ee ia?aa?a, 1-2 nooi?iue aeoeaiino?IICI, aaceni? caniae (o?iie?iia?, noeueoanaeacei, Ae-iai?oeeeai?i), EOE, ianaae, e?eoaaeueia oiaeueaa, ineoi- oa?aiaaoe/ia ei?aeoe?y, iaai?oieaca?ia ? iaoaiioa?ai?y (eiiieaen ?6)TH?A, noaeiaiaa oi?ia, iiiiie?aia?o?eo, iia?eueii i?ia?an., ia?aa?a, 1-2 nooi?iue. aeoeaiino?Eiiieaen ?3TH?A, noaeiaiaa (iie?a?o?eo) ? noaeiaiai-a?noea?aeuei? oi?ie, oaeaeei i?ia?an. ia?aa?a, aeoeai?noue 2-3 nooiEi?oeeinoa?i?aee, IICI, EOE, ianaae, e?eoaaeueia oiaeueaa, iaoaiioa?ai?y, ineoioa?aiaaoe/ia ei?aeoe?y (eiiieaen ?7)TH?A, noaeiaiai-a?noea?aeueia oi?ia, oaeaeei i?ia?. ia?aa?a, 2-3 no. aeo. ? a?aenooi?noue aoaeoo a?ae eiiieaeno ?7Eiiieaen ?8 (oeeoinoaoeee + eiiieaen ?7)AN, 1-2 nooi?iue aeoeaiino?Eiiieaen 1 Ia e?iaoeue niinoa?aaeaiiy iiceoeaiee ?acoeueoao e?eoaaiiy c iiaiei cai?ioiei ?icaeoeii ee?i?ei-eaai?aoi?ieo iciae caoai?thaaiiy iaa i?noea o 93,39% oai?eo ia ?aA, o 50,87% oai?eo ia THOA ? o 22,80% oai?eo ia TH?A. Caaeia?eueiee ?acoeueoao, yeee oa?aeoa?ecoaaany iia?eueiei i?ia?anoaaiiyi ee?i?/ii? neiioiiaoeee c iii??iei ii?ooaiiyi ooieoe?? noaeia?a i?e TH?A ? AN, ?aoeeaeeaaie noaeiaiaiai neiae?iio i?e THOA ? ?aA, neeaa a?aeiia?aeii: 36,8%; 63,6%; 49,1%; 6,6%. Io?eiai? aeai? na?ae/aoue i?i oa, ui aeei?enoaiiy ?ic?iaie ii ?aaa?e?oaoe?? i?aee?oe?a ?c o?ii?/ieie a?o?eoaie ni?ey? cieaeaiith /anoioe caaino?aiue, i?ia?anoaaiiy caoai?thaaiue, ?iaae?aeecaoe?? i?aee?oe?a ? ? iaaiei aianeii o aoi?eiio i?io?eaeoeeo aeaii? iaoieia??. AENIIAEE 1. O?ii?/i? a?o?eoe o i?aee?oe?a (?aaiaoi?aeiee a?o?eo, thaai?eueiee o?ii?/iee a?o?eo, ?aaeoeaiee a?o?eo, aie?eicoth/ee niiiaeeeia?o?eo) oa?aeoa?ecothoueny noiae?noth ee?i?/ieo i?iya?a noaeiaiaiai neiae?iio ia ii/aoeo caoai?thaaiiy ? iaeiiiai?aaeai?noth ci?i iieaciee?a caiaeueii? aeoeaiino?, aeenaaeaino O- ? A nenoai ?ioi?oaoo, ii?ooaiue iai?io niieo/ii-oeaieiieo no?oeoo?, i?e?ioee?eoeyoe??, a?aeoeeaiue ai?noo noaoaaeo noa?i?ae?a. Ia??ai? c oeei, eiaeia iicieia?/ia oi?ia ia? iniaeeaino?, ui aecia/athoueny aeeaeiith ? oyaee?noth iaoieia?/iiai i?ioeano, oaiiaie aaiethoe??, ia??iaeii noaoaaiai aeic??aaiiy. 2. THaai?eueiee o?ii?/iee a?o?eo ? naiino?eiei caoai?thaaiiyi, yea oa?aeoa?eco?oueny iaaenieith aeoeai?noth caiaeueiiai i?ioeano (82,6%), iiiiie?aia?oeeoey?ieie o?aaeaiiyie (88,4%), a?o?eoii eie?iieo ? aii?eeiainoiiieo noaeia?a, ui o?eaaei ( 4 i?nyoe? ? a?eueoa ) caa??aa?oueny, ?aoeeaeeaoth/ei ia?aa?aii oai?iae aac i?ia?anoaaiiy noaeiaiaiai neiae?iio. O ?aiiueiio ioaa?oaoiiio ia??iae? a?o?eo noi?iaiaeaeo?oueny ae?aaeaiei aenoaeaoeaiei eiiiiiaioii a ia?ea?oeeoey?ieo oeaieiao ? /anoeie ?aoeeaeeaaie oai?iae o 3/4 i?aee?oe?a. O aeania ioaa?oaoiiio ia??iae? ia?aaaaeathoue ie?aia?oeeoey?i? o?aaeaiiy ? ui??/i? ?aoeeaeeae caoai?thaaiiy (85.7%), aea ciaioo?oueny nooi?iue ee?i?/ieo i?iya?a a?o?eoo ? eiai o?eaae?noue. 3. ?aaeoeaiee a?o?eo o i?aee?oe?a ia? o?iiieia?/iee ca'ycie ?c ia?aianaiith ?ioaeoe??th, ia?aaaaeii iiniaeioeiaith, ??aeoa - eeoeiaith ? o?iaai?oaeueiith, oa?aeoa?eco?oueny i?aeaino?ei (86,5%) ii/aoeii, aneiao?e/iei iiiiie?aia?o?eoii aaeeeeo ? na?aaei?o noaeia?a ieaei?o e?ioe?aie ? o a?eueoino? oai?eo ?aoeeaeeaoaaiiyi noaeiaiaiai neiae?iio (63,0%). O ?aiiueiio ioaa?oaoiiio ia??iae? ia?aaaaea? ie?aia?o?eo (64, %) c ae?aaeaiei aieueiaei neiae?iiii ? aenoaeaoeaiei eiiiiiaioii caiaeaiiy. O ia??iae? aeania ioaa?oaoo niinoa??aa?oueny iaio yne?aaa neiioiiaoeea a?o?eoo ? /ano?oa o?aaeathoueny ae??ai? noaeiae noii (25,6%). A?aei?iiino? a o?eaaeino? a?o?eoo ? eiai /anoio? o i?aee?oe?a ia ie?aieo aoaiao noaiiaeaiiy noaoaai? ooieoe?? a?aenooi?. 4. No/aniee thaai?eueiee ?aaiaoi?aeiee a?o?eo oa?aeoa?eco?oueny aino?ei ? i?aeaino?ei ii/aoeii, ia?aaaaeaiiyi noaeiaiai? oi?ie (60,6%), ?aiiueith iiyaith ai?io?io?e (70,4%), ?aieiai? neooino? (76,4%), neiao?e/iei o?aaeaiiyi ae??aieo noaeia?a (57,3%), /anoei ?icaeoeii e?noeiai-o?yuiai? aeano?oeoe?? (52,9%), aenieeie oaiiaie i?ia?anoaaiiy ci?i a noaeiaao ? aioo??oi?o i?aaiao a ia?o? 3 ?iee oai?iae. O ?aiiueiio ioaa?oaoiiio ia??iae? iaea?eueo ae?aaeaia ee?i?/ia neiioiiaoeea a?o?eoo, eiai o?eaae?noue (6-10 i?nyoe?a) ? i?ia?anoaaiiy ci?i a noaeiaao ia ia?oiio ?ioe? oai?iae. O aeania ioaa?oaoiiio ia??iae? i?ie?oa?aoeai? ci?i? a noaeiaao ia?aaaaeathoue iaae aenoaeaoeaieie, o?eaae?noue a?o?eoo ia ia?aaeuo? 7 i?nyoe?a, a oaiie i?ia?anoaaiiy ia caeaaeaoue a?ae no?ie?a caoai?thaaiiy. 5. O i?aee?oe?a ia?aaaaea? ia?eoa?e/ia oi?ia aie?eicoth/iai niiiaeeeia?o?eoo c? no?eeei ? ?aoeeaeeaoth/ei, aea iia?eueii i?ia?anoth/ei a?o?eoii ia?aaaaeii ieaei?o e?ioe?aie, o?aaeaiiyi oacinoaaiiaeo noaeia?a (36,3%) ia ia?oiio ?ioe? oai?iae ? iia?eueieie oaiiaie ?icaeoeo ci?i a o?aao?, aenieith aeoeai?noth caiaeueiiai i?ioeano. O aeaatho? oai?iae ae?aaiinoe/ii cia/ou?: a?o?eo oacinoaaiiaeo noaeia?a, iayai?noue aioaciiao?e, i?aeaeuaiiy OCA a?eueoa ca 30 ii/aiae. ? ca?eueoaiiy a 1/5 - 2 ?ace iieaciee?a na?iioei?aeo, n?aeiaeo eeneio, ae?eii?ioa?ae?a ia oii? iii??ii ae?aaeaii? neiioiiaoeee ci?i a noaeiaao. 6. O iaoai?ciao ?icaeoeo ? iane?aeeao o?ii?/ieo a?o?eo?a aaaeeeaa ?ieue iaeaaeeoue ii?ooaiiyi iaoaaie?cio niieo/ii-oeaieiieo no?oeoo?, ye? i?iyaeythoueny i?e ia?aaiaoi?aeieo a?o?eoao ia?aaaaeii ci?iaie a iai?i? i?ioaiae?eai?a c ia?a?iciiae?eii o?aeoe?e AAA: ia?inoaiiyi ai?noo oiiae?i?oei -6-, -4- ? aea?iaoainoeueoao?a o oai?eo ia thaai?eueiee o?ii?/iee a?o?eo, oiiae?i?oei-6-noeueoao?a o i?aee?oe?a, oai?eo ia ?aaeoeaiee a?o?eo. THaai?eueiee ?aaiaoi?aeiee a?o?eo oa?aeoa?eco?oueny ca?eueoaiiyi I ? III o?aeoe?e AAA ? cieaeaiiyi II o?aeoe??, a?aeoeeaiiyie a iai?i? eieaaaio, i'yciai? oeaieie. Ci?ie a iaoaaie?ci? niieo/ii? oeaieie - ?acoeueoao ii?ooaiiy aca?iiae?? i?ae niieo/ii-oeaieiieie no?oeoo?aie, ?ioiiith nenoaiith, ano?aae?ieii. Aeyaeaiee ca'ycie ci?i a iai?i? i?ioaiae?eai?a c aeoeaaoe??th eenei? oinoaoace, eieaaaio- eoaeii? oinoaoace ia? ae?aaiinoe/io ? i?iaiinoe/io cia/ou?noue noiniaii ?icaeoeo aeano?oeoe?? e?noeiai? oeaieie. 7. I?e?ioee?eoeyoi?i? ii?ooaiiy i?e o?ii?/ieo a?o?eoao c?inoathoue c? nooiaiai aeoeaiino? ? aaia?ae?caoe??th iaoieia?/iiai i?ioeano. THaai?eueiee o?ii?/iee a?o?eo oa?aeoa?eco?oueny noaeeiieie (70,8%) ? aioo??oiueinoaeeiieie (54,2%) ?iceaaeaie, ?aaeoeaiee a?o?eo - ia?aaaaeaiiyi noaeeiieo ii?ooaiue (62,5%). Iaea?eueo ae?aaeai? ? iioe?ai? ci?ie, ui noinothoueny an?o eaiie i?e?ioee?eoeyoi?iiai ?onea, niinoa??aathoueny i?e noaeiaiai-a?noea?aeuei?e oi?i? thaai?eueiiai ?aaiaoi?aeiiai a?o?eoo ? aieeeicoth/iio niiiaeeeia?o?eo?. I?iaiinoe/ii iani?eyoeeaeie iciaeaie a?aeiinii ca?eueoaiiy o?eaaeino? a?o?eoo i?e thaai?eueiiio ?aaiaoi?aeiiio a?o?eo? ? ci?ie oi?ie, ui no?eei caa??aathoueny, ? oiiono noaeeiieo no?iie, ia?eaaneoey?i? ii?ooaiiy, ?ao?ia?aaeiee e?iaioie ? noace; i?e thaai?eueiiio o?ii?/iiio ? ?aaeoeaiiio a?o?eoao - no?eeee niaci a?oa??ie. 8. O ?icaeoeo o?ii?/ieo a?o?eo?a ?noioia cia/aiiy iathoue ci?ie o aca?iiae?? noaoaaeo ai?iii?a e ?ioiii? nenoaie. Anoaiiaeaii, ui i?e o?ii?/ieo a?o?eoao ??cii? i?e?iaee a?aeoeeaiiy ai?noo noaoaaeo noa?i?ae?a iathoue iaeiiiai?aaeaiee oa?aeoa? ? i?iyaeythoueny cieaeaiiyi oanoinoa?iio ? i?aeaeuaiiyi aai cieaeaiiyi ano?aae?ieo. Iaeiae aeai? ei?aeyoe?eieo ca'yce?a noaoaaeo ai?iii?a c iieacieeaie ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo ? oaeoi?ii? iiaeae? aca?iica'yce?a iieaciee?a na?ae/aoue i?i oa, ui i?e thaai?eueiiio o?ii?/iiio ? ?aaeoeaiiio a?o?eoao ia oa?aeoa? ?ioiiiaoieia?/ieo ?aaeoe?e a a?eueo?e i??? aieeaa? ano?aae?ie, i?e thaai?eueiiio ?aaiaoi?aeiiio a?o?eo? - iaeii/anii iaeaeaa ai?iiie, iineethth/e aoaeo aioeo?eiooai?thaaiiy, e ?ioiiiaoieia?/iee i?ioean iaaoaa? a?eueoo “aa?aneai?noue”. 9. THaai?eueiee o?ii?/iee ? ?aaeoeaiee a?o?eoe a?aeiinyoueny aei caoai?thaaiue ?c niaaeeiaith noeeuei?noth ? iie?aaiiei oeiii oniaaeeoaaiiy c iayai?noth a n?i'yo oai?eo aa?aaaoe?? ?aaiaoe/ieo caoai?thaaiue e ?o i?aeaeuai?e iioe?aiino? na?aae ?iaee/?a ia?oiai nooiaiy nii??aeiaiino?, i?e?ioi?i oai?ia ? iaa?aeiia?aei?noth oaeoe/iiai ?iciiae?eo oai?eo ?iaee/?a aeii?iaioi?e ? ?aoeaneai?e iiaeae? oniaaeeoaaiiy. Aecia/aii anioe?aoeai? ca'ycee i?ae aioeaaiaie HLA ? caoai?thaaiiyie. Ia?ea?ii thaai?eueiiai o?ii?/iiai a?o?eoo ? A3, A28, A40; ?aaeoeaiiai a?o?eoo- A10, A8, ?aoeeaeeaoth/iai ia?aa?ao ?aaeoeaiiai a?o?eoo – aaieioei N3,4. O?ii?/i? a?o?eoe oa?aeoa?ecothoueny ca?aeithaaiiyi aea?iaoiae?o?/iiai ?enoiea ia iaeueoeyo ? aeieiiyo. O?niee ei?aeyoe?eiee ca'ycie aaiaoe/ieo ia?ea??a c ?ioiiaeiaoe?iaie, eiiieaiaioii, e?ciniiaeueieie oa?iaioaie aeaco? ia iiaeeea? aaiaoe/ii aeaoa?i?iiaai? aeaoaeoe a ?o no?oeoo?ao. 10. I?ia?aia aeeoa?aioe?eiaaiiai e?eoaaiiy ia?aaiaoi?aeieo a?o?eo?a, aa?o/e aei oaaae cia/i? ii?ooaiiy a ?ioii?e nenoai?, iai?i? niieo/ii- oeaieiieo no?oeoo?, i?e?ioee?eoeyoe?? e ?o iniaeeaino? i?e eiaei?e iicieia?/i?e oi?i?, ia?aaeaa/a? aoaii?noue, ?iaeea?aeoaeuei?noue, i?ecia/aiiy iaaeeeaiaioicieo i?aia?ao?a ? o?ce/ieo iaoiae?a ?aaa?e?oaoe??. E?eoaaiiy oai?eo ia thaai?eueiee o?ii?/iee a?o?eo aeeth/a? IICI, ye? c iaoith iiia?aaeaeaiiy ?aoeeaeea?a ? i?ia?anoaaiiy noaeiaiaiai neiae?iio canoiniaothoueny i?ioyaii onueiai ia??iaeo ee?i?ei-eaai?aoi?ieo i?iya?a caiaeueiiai i?ioeano ? a i?aeo?eioth/eo aeicao i?ioyaii ianooiieo 1,5-3 i?nyoe?a i?ney eiai cieeiaiiy. I?e ae?aaeaiiio aenoaeaoeaiiio eiiiiiaio? ? oaiaeaioe?yo aei ca?eueoaiiy o?eaaeino? a?o?eoo aeei?enoiao?oueny aioo??oiueinoaeiaiaa aaaaeaiiy i?aia?ao?a, a i?e oi?i?aeiiio ? /anoi ?aoeeaeeaoth/iio a?o?eo? - ?aii? i?ecia/aiiy aacenieo cania?a ( o?iie?iiaeo i?aia?ao?a, naeaciie?eaeaceio) no?ieii 6 - 12 i?nyoe?a. O?eaae?noue aioeaaeoa??aeueii? oa?ai?? o oai?eo ia ?aaeoeaiee a?o?eo neeaaea? ia iaioa o?ueio oeaei?a, e?eoaaiiy IICI - aei noeoaiiy iciae a?o?eoo ? 1-2 i?nyoe? i?ney eiai onoiaiiy. 11. Iiceoeaiee ?acoeueoao e?eoaaiiy c iiaiei cai?ioiei ?icaeoeii ee?i?ei-eaai?aoi?ieo iciae caoai?thaaiiy niinoa??aa?oueny o 93,3% oai?eo ia ?aaeoeaiee a?o?eo, o 50,8% i?aee?oe?a, oai?eo ia thaai?eueiee o?ii?/iee a?o?eo ? o 22,8% oai?eo ia thaai?eueiee ?aaiaoi?aeiee a?o?eo. Caaeia?eueiee aoaeo, ui aeeth/a? iia?eueia i?ia?anoaaiiy ee?i?/ii? neiioiiaoeee i?e thaai?eueiiio ?aaiaoi?aeiiio a?o?eo? e aieeeicoth/iio niiiaeeeia?o?eo?, /anoa ?aoeeaeeaoaaiiy noaeiaiaiai neiae?iio i?e thaai?eueiiio o?ii?/iiio ? ?aaeoeaiiio a?o?eoao noaiiaeoue a?aeiia?aeii: 36,8%; 63,6%; 49,1%; 6,6%. Ia e?iaoeue niinoa?aaeaiiy aeaeoaeaiiy ianoaei o 20,0 % oai?eo ia thaai?eueiee o?ii?/iee a?o?eo ? o 66,3% i?aee?oe?a , oai?eo ia ?aaeoeaiee a?o?eo, a oaeiae no?eea, a?eueoa ca 7 ?ie?a ?ai?n?y o 32,5 % aeiaaee?a i?e iiiiie?aia?oeeoey?iiio thaai?eueiiio ?aaiaoi?aeiiio a?o?eo?. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey aeeoa?aioe?aeueii? ae?aaiinoeee o?ii?/ieo a?o?eo?a ??cii? i?e?iaee, a oaeiae i?iaiico iaio ni?eyoeeaiai ia?aa?ao iaoieia?/iiai i?ioeano iaiao?aeii aeei?enoiaoaaoe aeai?eoie, ?ic?iaeai? c o?aooaaiiyi a?aei?iiinoae a ee?i?/ieo i?iyaao caoai?thaaiue, a?io?i?/ieo iieacieeao aeoeaiino? caiaeueiiai i?ioeano, ?ioiieia?/ieo, aea?iaoiae?o?/ieo ia?aiao?ao ? iieacieeao iaoaaie?cio niieo/ii-oeaieiieo no?oeoo?. 2. I?e thaai?eueiiio o?ii?/iiio a?o?eo? i?iaiinoe/ii iaio ni?eyoeea? a?aeiinii /anoiai ?aoeeaeeaoaaiiy i?ioeano ? : ?aoeeaeeae a?o?eoo ia ia?oiio ?ioe? oai?iae, o?eaae?noue iiaoi?ieo a?o?eo?a a?eueo aeaio i?nyoe?a, cieaeaiiy eiiieaiaioo, i?aeaeuaiiy iieaciee?a IgG, i?e?aeiaiiy o?aaeaiue ?ai?oa caei?iaeo noaeia?a i?ioyaii ia?oiai ?ieo oai?iae, a?aenooi?noue oe?eeii cai?ioiiai ?icaeoeo a?o?eoo ia e?iaoeue ia?oiai ?ieo oai?iae. 3. O i?iaiic? ?aoeeaeeaoth/iai ia?aa?ao ?aaeoeaiiai a?o?eoo iaiao?aeii a?aoiaoaaoe: iayai?noue o?ii?/ieo aiaieu ?ioaeoe??, a?o?eoo e?eoueiaeo noaeia?a, a?eueoa o?ueio noaeia?a c aenoaeaoii, i?aei'yoeiaiai ao?neoo, o?eaae?noue a?o?eoo a?eueoa 1,5 i?nyoe?a, ?aoeeaeeae a?o?eoo ia ia?oiio ?ioe? oai?iae. 4. Aei /enea iani?eyoeeaeo iieaciee?a a?aeiinii ca?eueoaiiy o?eaaeino? a?o?eoo i?e thaai?eueiiio ?aaiaoi?aeiiio a?o?eo? iio??aii a?aeiineoe: cia/i? ? no?ee? ci?ie oi?ie ? oiiono noaeeiii? no?iee, iayai?noue ia?eaaneoey?ieo ii?ooaiue, ?ao?ia?aaeiiai e?iaioieo; i?e thaai?eueiiio o?ii?/iiio ? ?aaeoeaiiio a?o?eoao - no?eeee niaci a?oa??ie. 5. I?aee?oe?a c iaoyaeaiith niaaeeia?noth ii ?aaiaoe/ieo caoai?thaaiiyo, iniaeeai in?a ae?ii/i? noao?, a ia??iae? iiyae aoi?eiieo noaoaaeo iciae ? oai?eo o aeania ioaa?oaoiiio ia??iae? iaiao?aeii aaaaeaoe a?oiith i?aeaeuaiiai ?eceeo ii iiaeeeaiio ?icaeoeo a?eueo oyaeeeo aa??aio?a ia?aa?ao thaai?eueiiai o?ii?/iiai, ?aaiaoi?aeiiai ? ?aaeoeaiiai a?o?eo?a. 6. E?eoaaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe, iiaeiii aooe aoaiiei, eiiieaeniei, o?eaaeei c aeeth/aiiyi iaaeeeaiaioicieo cania?a ? ?aii?i i?ecia/aiiyi o?ce/ieo iaoiae?a - e?eoaaeueii? o?ceoeueoo?e c ?ic?iaeith noaeia?a, ianaaeo, o?c?ioa?ai??. 7. Eiioeiaaioe c i?iaiinoe/ii iani?eyoeeaeie aa??aioaie ia?aa?ao caoai?thaaiiy iio?aaothoue ?aoaeueiiai aeeniaina?iiai niinoa?aaeaiiy, a oiio /ene? a ia??iae ?ai?n?? aeey ooi/iaiiy oa?aeoa?o aaiethoe?? ee?i?/ii? neiioiiaoeee ? ei?aeoe?? oa?ai??. NIENIE IAOEIAEO ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1.Eaaaoeue ?.N. Oa?aeoa?enoeea ee?i?/ieo i?iya?a thaai?eueiiai o?ii?/iiai a?o?eoo // Iaae?ao??y, aeooa?noai ? a?iaeieia?y. - 1996. - ?4. - N. 71 - 72. 2. Eaaaoe E.N. ?ieue iieiauo noa?ieaeia a ?acaeoee caaieaaaiee nonoaaia o iiae?inoeia// Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1996.- ?4. - N.55 - 61. 3. Eaaaoe E.N. Cia/aiea ianeaaenoaaiiiai oaeoi?a i?e ainiaeeoaeueiuo caaieaaaieyo nonoaaia o iiae?inoeia //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1996. - ?4. - N. 62 - 69. 4. Eaaaoe E.N. Eeeieei-eiioiieiae/aneay oa?aeoa?enoeea ?aaeoeaiuo a?o?eoia o iiae?inoeia// Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.- 1996.- ?4.-N.70 - 74. 5. Eaaaoe E.N. Eiioiieiae/aneay oa?aeoa?enoeea caaieaaaiee nonoaaia o iiae?inoeia //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1996. - ?8. - N.34-41. 6. Eaaaoeue ?.N. Ae?aaiinoeea aeaoi?ioth/iai inoaia?o?ico o ae?oae ? i?aee?oe?a //Iaae?ao??y, aeooa?noai ? a?iaeieia?y. - 1997. - ?5-6. - N. 29-32. 7. Einoth??ia A.I., Eaaaoeue ?.N., Aiaiao E.O., Eieii??oeue A.I., Oeiio??aa I.I. Iniaeeaino? no/aniiai ia?aa?ao oa iane?aee?a iiiiie?aia?oeeoey?iiai ?aaiaoi?aeiiai a?o?eoo o i?aee?oe?a// Iaae?ao??y, aeooa?noai ? a?iaeieia?y. - 1997. - ?1. - N.17 - 19. 8. E?aiiee ?. I., Eou I.?., Aa?eooa A.I, Eaaaoeue ?.N. ?aioaaiieia?/i? iniaeeaino? inoaioiiae?ico a aeeoy/iio ? i?aee?oeiaiio a?oe? //Iaae?ao??y, aeooa?noai ? a?iaeieia?y. - 1989. - ? . - N. 29 - 30. 9. Eaaaoe E.N. ?aaeoeaiue a?o?eo o iiae?inoeia: iniaaiiinoe oa/aiey e iaoaaieeci niaaeeieoaeueii-oeaiiuo no?oeoo? // I?oiiaaeey, o?aaiaoieiaey e i?ioace?iaaiea. - 1998. - ?2. - N.40 – 42. 10. Eaiioueaaa O.N., Eaaaoe E.N. Eeeieei-aeioeie/aneay oa?aeoa?enoeea ?aaiaoieaeiiai a?o?eoa o iiae?inoeia // I?oiiaaeey, o?aaiaoieiaey e i?ioace?iaaiea. - 1998. - ? 2. - N.83 – 86. 11. Eaaaoe E.N. Iniaaiiinoe oa/aiey aieeeice?othuaai niiiaeeeia?o?eoa o iiae?inoeia // I?oiiaaeey, o?aaiaoieiaey e i?ioace?iaaiea. - 1998.-?3.- N.84 - 86. 12. Eaaaoeue ?.N. Aei ieoaiiy ae?aaiinoeee thaai?eueiiai o?ii?/iiai a?o?eoo //Iaae?ao??y, aeooa?noai ? a?iaeieia?y. - 1998. - ?3. - N.31 – 33. 13. Eaaaoe E.N. E aii?ino i iaoiaaiaca thaaieeueiiai o?iie/aneiai a?o?eoa //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1998. ? 6 . - N.94 – 102. 14. Eaaaoe E.N. Ninoiyiea iee?ioee?eoeyoeee i?e o?iie/aneeo a?o?eoao o iiae?inoeia //Aanoiee i?iaeai aeieiaeee e iaaeeoeeiu. - 1998. - ? 8 . - N.146 – 153. 15. Eaaaoe E.N. N?aaieoaeueiay oa?aeoa?enoeea ia?ooaiee iaiaia niaaeeieoaeueiie oeaie i?e o?iie/aneeo a?o?eoao o iiae?inoeia // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1998. - ? 5. - N. 58 – 64. 16. Eaaaoeue ?. N . Iniaeeaino? no/aniiai ia?aa?ao ?aaiaoi?aeiiai a?o?eoo o i?aee?oe?a // I?aeoe/ia iaaeeoeeia. - 1996. - ? 1 - 2. - N. 12 - 16. 17. Eaaaoe E.N., Einoth?eia A.I. Aeooaeueiua i?iaeaiu caaieaaaiee nonoaaia o iiae?inoeia// A?a/aaiay i?aeoeea. - 1998. - ?2. - N.4 - 7. 18. Einoth?eia A.I., Eaaaoe E.N., Oaa/aiei I.I., Oeiioaaaa I.I. Ineiaeiaiey ei?oeeinoa?ieaeiie oa?aiee o iiae?inoeia n aeeooociuie aieaciyie niaaeeieoaeueiie oeaie // Aeaoneay ?aaiaoieiaey. - 1997. - ? 4. - N. 9 – 14. 19.Einoth?eia A.I, Eaaaoe E.N. ?aaiaoieaeiue a?o?eo //Ni?aai/iee a?a/a iiae?inoeiaiai eaaeiaoa. - E.:Caei?iay, 1991.- N.161-166. 20. Einoth?eia A.I., Eieiieaoe A.I. Eaaaoe E.N. I?aaiecaoeey aeeniaina?iiai iaaethaeaiey iiae?inoeia, aieiuo ?aaiaoieaeiui a?o?eoii //Io?aia caei?iauey aeaoae e iiae?inoeia: ?ani. iaaeaaae. na. - E., 1986. - Aui. 17. - N. 35 - 38. 21. Einoth?eia A.I., Eieiieaoe A.I., Eaaaoe E.N. I?aaiecaoeey aeeniaina?ecaoeee iiae?inoeia, aieueiuo ?aaiaoieaeiui a?o?eoii //Nioeeaeueiay aeaeaia, i?aaiecaoeey cae?aaiio?aiaiey e enoi?ey iaaeeoeeiu: ?ani. iaaeaaae. na. - E. , 1987. - Aui. 18. - N. 64 - 67. 22. Eaaaoe E.N. Aaiaoe/aneea aniaeou ?aaiaoieaeiiai a?o?eoa o iiae?inoeia // Io?aia caei?iauey aeaoae e iiae?inoeia: ?ani. iaaeaaae. na. - E., 1989. - Aui. 20. - N. 22-25. 23.Eaaaoe E.N. Aea?iaoiaeeoe/aneay oa?aeoa?enoeea caaieaaaiee nonoaaia o iiae?inoeia //Io?aia caei?iauey aeaoae e iiae?inoeia: ?ani.iaaeaaae. na.- E.,1994.- Aui.24.- N.105- 108. 24. Eaaaoe E.N. Aeeaaiinoe/aneea e i?iaiinoe/aneea aeai?eoiu thaaieeueiiai o?iie/aneiai e ?aaeoeaiiai a?o?eoa // Io?aia caei?iauey aeaoae e iiae?inoeia: ?ani.iaaeaaae. na. - E., 1996. - Aui.25. - N. 26 - 29. 25. Eaaaoe E.N. Iniaaiiinoe iaiaia niaaeeieoaeueiie oeaie i?e thaaieeueiii o?iie/aneii a?o?eoa o iiae?inoeia // Io?aia caei?iauey aeaoae e iiae?inoeia: ?ani.iaaeaaae. na. - E., 1996. Aui.25. N. 121 - 124. 26. Eaaaoe E.N., Einoth?eia A.I., Eieiieaoe A.I. I?eioeeiu ainnoaiiaeoaeueiiai ea/aiey caaieaaaiee nonoaaia o aeaoae e iiae?inoeia // O?. ei-oa aeaoneie eo?i?oieiaee e oeceioa?aiee: - Aaiaoi?ey, 1993. - Aui.1.- N.51- 42. 27. Einoth?eia A.I., Eaaaoe E.N., Oaa?eoieeiaa E.E. Yaiethoeey e enoiaeu iiiiieeaia?oeeoey?iiai TH?A // O?. ei-oa aeaoneie eo?i?oieiaee e oeceioa?aiee: - Aaiaoi?ey, 1995. –Aui.3.- N. 32 - 33. 28. Einoth?eia A.I., Aiaiao E.O., Eaaaoe E.N., Oeiioaaaa I.I., Oaa/aiei I.N. Eiiieaeniia aeeooa?aioee?iaaiiia ea/aiea aeaoae e iiae?inoeia n o?iie/aneeie a?o?eoaie ia yoaiao ?aaaeeeoaoeee // O?. ei-oa aeaoneie eo?i?oieiaee e oeceioa?aiee : - Aaiaoi?ey, 1997. - Aui. 5. - N. 43. 29. Einoth?eia A.I., Eaaaoe E.N., Eieiieaoe A.I., Oeiioaaaa I.I. ?aaaeeeoaoeey aeaoae e iiae?inoeia, aieueiuo ?aaiaoieaeiui a?o?eoii //O?. ei-oa aeaoneie eo?i?oieiaee e oeceioa?aiee: - Aaiaoi?ey, 1998. – Aui.6. – N. 54 – 56. 30. Lebets I.S., Kostoyrina G.N., Kramnoy I.E. On the problem of diagnosing dysplastic lesions of bones and joints in children and adolescents // 16 th Symposium the European society of osteoarthrology. - Moscow: Abstr.- I.., 1987. - P. 84. 31. Eistyurina G.N., Eramnoy I..E., Lebets I.S. Clinicoroentgenologic characteristics of osteochondrosis in adolescents // 16 th Symposium the European society of osteoarthrology. – Moscow: Abstr. – M., 1987. - P.75. 32. Eieiieaoe A.I., Einoth?eia A.I., Eaaaoe E.N., Iano?oaaa C.I. I?eiaiaiea oece/aneeo oaeoi?ia a ainnoaiiaeoaeueiii ea/aiee aieueiuo thaaieeueiui ?aaiaoieaeiui a?o?eoii// Ananithci. eiio. ?aaiaoieiaia : Oac.aeiee. - I., 1988. N.96. 33. Einoth?eia A.I., Eaaaoe E.N.,Eieiieaoe A.I.,Oaa?eoieeiaa E.E., Nu?iaaoneay A.E. Aioo?enonoaaiia i?eiaiaiea aeae?iei?oeciia e oeeeeioinoaieaea o iiae?inoeia i?e ?aaiaoieaeiii a?o?eoa // Ananithci. eiio. ?aaiaoieiaia : Oac.aeiee. - I., 1988. - N.97. 34. Einoth?eia A.I., Eaaaoe E.N., Aaaaoeeay I.A., Oaa?eoieeiaa E.E. Eeeieei - aaiaoe/aneea aniaeou ?aaiaoieaeiiai a?o?eoa o aeaoae e iiae?inoeia // Aaiaoe/aneea ia?ea?u a aio?iiiaaiaoeea e iaaeeoeeia : Oac.aeiee. IV Ananithci. neiiiceoia aaiaoeeia. - Oiaeueieoeeee, 1988. - N.184 - 185. 35. Einoth?eia A.I., Eaaaoe E.N., E?eae/ E.I., Aaaaoeeay I.A., A?eoei A.A. Eeeieei-aea?iaoiaeeoe/aneay oa?aeoa?enoeea ?aaiaoieaeiiai a?o?eoa o iiae?inoeia // I nuacae iaaeeoeeineeo aaiaoeeia Oe?aeineie NN? : Oac.aeiee. - Eueaia, 1988. - N.47 - 48. 36. Einoth?eia A.I., E?eae/ E.I., Eaaaoe E.N., Aaaaoeeay I.A., Aaiaoe/aneea aniaeou o?iie/aneeo a?o?eoia // I?aiaoaeueiue e iaiiaoaeueiue ne?eieia a?iaeaeaiiie e ianeaaenoaaiiie iaoieiaee : Oac.aeiee Ananithci. iao/.-i?aeo.eiio. - Oa?ueeia, 1990. - N.72 - 73. 37. Einoth?eia A.I., Eieiieaoe A.I., Eaaaoe E.N., Iano?oaaa C.I. Ineoieiae/aneay e oece/aneay ?aaaeeeoaoeey iiae?inoeia, aieueiuo ?aaiaoieaeiui a?o?eoii // Ieaioi ?anioae. iaoeiai –iaaee/iiai oiaa?enoaa ?aaiaoieia?a : Oace aeiiia. - E.,1991.- N. 48. 38. Einoth?eia A.I., Eaaaoe E.N., Eieiieaoe A.I., Yoaiiia ea/aiea ?aaiaoieaeiiai a?o?eoa o iiae?inoeia // IV Ananithci. nuacae ?aaiaoieiaia : Oac.aeiee. - I., 1991. - N. 109 - 110. 39. Eaaaoe E.N., Einoth?eia A.I., Oeiioaaaa I.I. N?aaieoaeueiay oa?aeoa?enoeea thaaieeueiiai o?iie/aneiai e ?aaeoeaiiai a?o?eoia o iiae?inoeia // IV Ananithci. nuacae ?aaiaoieiaia : Oac. aeiee. - I., 1991. - N.111 -112. 40. E?eae/ ?.I., Eaaaoeue ?.N.. Aaaaoeueea I.A., Aeeiiaa I.A., Iniaeeaino? ee?i?/ieo i?iya?a ?aaeoeaieo a?o?eo?a o i?aee?oe?a// I Eiia?an ?aaiaoieia?a Oe?a?ie : Oac.aeiiia.. - E., 1993. - N. 65. 41. Eaaaoeue ?.N., Einoth??ia A.I., Oeiioa?aa I.I., Aieiaei A.I. Ee?i?ei-ae?aaiinoe/i? aniaeoe caiaethaaeueieo oa aeaaaia?aoeaieo caoai?thaaiue noaeia?a o i?aee?oe?a // I Eia?an ?aaiaoieia?a Oe?a?ie : Oace aeiiia. - E., 1993. - N. 71 - 72. 42. Einoth??ia A.I., Oaa??oi?eiaa E.?., Eaaaoeue ?.N. Aei ieoaiue i?i ee?i?/io oa iaoiaaiaoe/io aaoa?iaaii?noue ?aaiaoe/ieo caoai?thaaiue o i?aee?oe?a // I Eiia?an ?aaiaoieia?a Oe?a?ie : Oace aeiiia.- E., 1993. - N. 63. 43. E?eae/ E.I., Aaaaoeeay I.A., Aeeiiaa A.A., Eaaaoe E.N. Oa?aeoa?enoeea aioeaaiia nenoaiu HLA e N - aaoa?io?iiaoeiiauo ?aeiiia o?iiinii i?e ?aaeoeaiii a?o?eoa o iiae?inoeia // I?iaeaiu eeeie/aneie aaiaoeee e i?aiaoaeueiie aeeaaiinoeee : Oac. aeiee. II Iaaeaeoi. neiiiceoia. - Oa?ueeia, 1994. - N. 38 - 39. 44. Einoth?eia A.I., Eaaaoe E.N.. Oeiioaaaa I.I., Yaiethoeey e enoiaeu iiiiieeaia?oeeoey?iuo oi?i o?iie/aneeo a?o?eoia o iiae?inoeia // Aeooaeueiua aii?inu ?aaiaoieiaee : Iaoa?eaeu ?anioae. neiiiceoia. - Iaeanna, 1995. -N.45- 46. 45. Eaaaoeue ?.N., E?eae/ ?.I., Aaaaoeueea I.A. ?ieue aaiaoe/ieo oaeoi??a o ?icaeoeo ?aaiaoe/ieo caoai?thaaiue //Iaoa??aee II c’?caeo iaaee/ieo aaiaoee?a Oe?a?ie. - Euea?a, 1995. - N. 92. 46. Eaaaoeue ?.N., Einoth??ia A.I., Oeiioa?aa I.I. Aaaaoeueea I.A. Aei ieoaiiy i?i o?ii?/i? a?o?eoe o i?aee?oe?a // Iaoa??aee II Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a Oe?a?ie. - E., 1997. - N. 40 - 41. 47. Eaaaoeue ?.N., Oeiioa?aa I.I., Naai ?..Ae., Iae?ia ?. I. Nenoaii? oi?ie ?aaiaoi?aeiiai a?o?eoo o i?aee?oe?a //Iaoa??aee II Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a Oe?a?ie. - E., 1997. - N.41. 48. Einoth?eia A.I., Eaaaoe E.N. Ea/aiea aeaoae e iiae?inoeia n o?iie/aneeie a?o?eoaie //II nuacae ?aaiaoieiaia ?innee : Oac. aeiee.. I., 1997. - N. 102 -103. Aiioaoe?? Eaaaoe ?.N. Iniaeeaino? no/aniiai ia?aa?ao o?ii?/ieo a?o?eo?a o i?aee?oe?a (ee?i?ea, ae?aaiinoeea, e?eoaaiiy). - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeueiinoth 14.01.10 - iaae?ao??y. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. I?aaenoaaeai? ?acoeueoaoe aeine?aeaeaiiy i?aee?oe?a ?c caiaeueieie caoai?thaaiiyie noaeia?a. Aeaia oa?aeoa?enoeea ii/aoeiaei i?iyaai, aaiethoe?? ee?i?/ii? neiioiiaoeee, iane?aeeai thaai?eueiiai o?ii?/iiai, thaai?eueiiai ?aaiaoi?aeiiai, ?aaeoeaiiai a?o?eo?a ? aie?eicoth/iai niiiaeeeia?o?eoo. I?iaiae?ciaai? iniaeeaino? ia?aa?ao caoai?thaaiue ia aoaiao noaoaaiai aeic??aaiiy i?aee?oe?a. I?e ??cieo ee?i?/ieo oi?iao o?ii?/ieo a?o?eo?a aecia/ai? iaea?eueo oa?aeoa?i? ii?ooaiiy a iaoaaie?ci? niieo/ii-oeaieiieo nooeoo?, i?e?ioee?eoeyoe??, nenoaiao ?ioi?oaoo, ai?no? noaoaaeo noa?i?ae?a. Io?eiai? iia? aeai? i?i cia/ou?noue aaiaoe/ieo oaeoi??a o ?icaeoeo o?ii?/ieo a?o?eo?a, ?o anioe?aoe?? c aaiaoe/ieie ia?ea?aie, a oaeiae ?ieue aca?iica'yceo i?ae noaoaaeie noa?i?aeaie, ?ioiieia?/ieie iieacieeaie, eiiiiiaioaie niieo/ii? oeaieie, aaiaoe/ieie ia?ea?aie. Cai?iiiiiaaia eiioeaioe?y ?icaeoeo thaai?eueiiai o?ii?/iiai a?o?eoo. ?ic?iaeaii e?eoa??? aeeoa?aioe?aeueii? ae?aaiinoeee o?ii?/ieo a?o?eo?a ??cii? i?e?iaee, i?iaiicoaaiiy oyaeeino? ?o ia?aa?ao. Iaa?oioiaai? ? i?aaenoaaeai? i?iiiceoe?? uiaei aeeoa?aioe?eiaaiiai e?eoaaiiy i?aee?oe?a. ?ic?iaeaii e?eoa??? aoaeoeaiino? oa?ai?? ? i?iaaaeaia ?ioaa?aeueia ?? ioe?iea. Aecia/ai? iniiai? i?eioeeie aeeniaina?iiai niinoa?aaeaiiy i?aee?oe?a ?c caoai?thaaiiyie noaeia?a ??cii? i?e?iaee ?c o?aooaaiiyi i?iaaaeaiiy e?eoaaeueii-icaei?ia/eo caoiae?a uiaei iiia?aaeaeaiiy caaino?aiue iaoieia?/iiai i?ioeano i?e eiaei?e iicieia?/i?e oi?i?. Eeth/ia? neiaa: i?aee?oee, o?ii?/i? a?o?eoe, ee?i?ea, noaoaa? noa?i?aee, nenoaie ?ioi?oaoo, niaaeeia?noue, iaoaaie?ci niieo/ii? oeaieie, aeeoa?aioe?aeueia ae?aaiinoeea, e?eoaaiiy, aeeniaina?ia niinoa?aaeaiiy. Eaaaoe E.N. Iniaaiiinoe nia?aiaiiiai oa/aiey o?iie/aneeo a?o?eoia o iiae?inoeia ( eeeieea, aeeaaiinoeea, ea/aiea). – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 – iaaeeao?ey. – Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. I?aaenoaaeaiu ?acoeueoaou enneaaeiaaiey iiae?inoeia n ainiaeeoaeueiuie caaieaaaieyie nonoaaia, a oii /enea thaaieeueiui o?iie/aneei, thaaieeueiui ?aaiaoieaeiui, ?aaeoeaiui a?o?eoaie, aieeeice?othuei niiiaeeeia?o?eoii. A?oiio iaaethaeaiey ninoaaeee 343 iiae?inoea n o?iie/aneeie a?o?eoaie. Eniieueciaaiu eeeie/aneea, aeioeie/aneea, eiioiieiae/aneea, ?aaeeieiioiieiae/aneea, aaiaoe/aneea enneaaeiaaiey. Ia iniiaaiee aeeeoaeueiiai i?iniaeoeaiiai iaaethaeaiey ( aei 10 eao) aieueiuo e ?ao?iniaeoeaiiai aiaeeca eeeie/aneie neiioiiaoeee ii?aaeaeaiu iniaaiiinoe oa/aiey e enoiaeu ?acee/iuo ii i?e?iaea caaieaaaiee nonoaaia. Onoaiiaeaii, /oi thaaieeueiue o?iie/aneee a?o?eo, eiay ?yae iaueo eeeie/aneeo /a?o n thaaieeueiui ?aaiaoieaeiui a?o?eoii, ioee/aaony aieaa aeaaii?eyoiui oa/aieai e enoiaeaie. Auyaeaiu ioee/ey a i?iyaeaieyo eco/aaiie iaoieiaee o iiae?inoeia ia yoaiao iieiaiai nic?aaaiey, i?e/ai a ?aiiai ioaa?oaoiii ia?eiaea ioia/aia iaeaieaa au?aaeaiiay neiioiiaoeea nonoaaiuo ii?aaeaiee n y?eei yennoaeaoeaiui eiiiiiaioii. A nianoaaiii ioaa?oaoiii ia?eiaea thaaieeueiue o?iie/aneee ioee/aaony /anouie ?aoeeaeeaaie, thaaieeueiue ?aaiaoieaeiue a?o?eo – i?aiaeaaeaieai i?ieeoa?aoeaiuo eciaiaiee iaae yennoaeaoeaiuie. O aieueiuo n o?iie/aneeie a?o?eoaie onoaiiaeaiu oa?aeoa?iua aeey eaaeaeie iicieiae/aneie oi?iu neiaeiua ia?ooaiey a iaoaaieecia eieeaaaia, i?ioaiaeeeaiia, iuoa/iie oeaie, aeoeaaoeey oa?iaioia eeneie e uaei/iie oinoaoac, e?aoeieeiacu, ioeeiiaiey a iaiaia eaeueoeey. Iaeaieaa cia/eoaeueiua eciaiaiey a iaoaaieecia ?acee/iuo eiiiiiaioia niaaeeieoaeueiie oeaie auyaeaiu i?e thaaieeueiii ?aaiaoieaeiii a?o?eoa; i?e thaaieeueiii o?iie/aneii e ?aaeoeaiii a?o?eoao i?aiaeaaeaei ia?a?ani?aaeaeaiea o?aeoeee aeeeiciaieiiaeeeaiia. I?e ?acee/iuo ii i?e?iaea o?iie/aneeo a?o?eoao ii?aaeaeaia naycue ia?ooaiee a iaiaia i?ioaiaeeeaiia n aeoeaaoeeae eeneie oinoaoacu, eieeaaaia – uaei/iie oinoaoacu. Auyaeaiu nouanoaaiiua eciaiaiey a iee?ioee?eoeyoi?iii ?onea. THaaieeueiue o?iie/aneee a?o?eo oa?aeoa?ecoaony ninoaeenouie e aioo?eninoaeenouie ia?ooaieyie, thaaieeueiue ?aaiaoieaeiue a?o?eo – ii?aaeaieai anao caaiueaa iee?ioee?eoeyoeee, ?aaeoeaiue a?o?eo – i?aiaeaaeaieai ninoaeenouo eciaiaiee. Onoaiiaeaia naycue iee?ioee?eoeyoi?iuo ?anno?ienoa n aeoeaiinoueth iaoieiae/aneiai i?ioeanna. Ii?aaeaeaii, /oi eiioiieiae/aneea naeaeae i?e o?iie/aneeo a?o?eoao o iiae?inoeia ?acaeaathony ia oiia eciaiaiee a oa?aeoa?a ?aaoee?othuaai aeeyiey iieiauo noa?ieaeia ia eiioiiua ?aaeoeee. I?e yoii ioeeiiaiey a niaea?aeaiee iieiauo ai?iiiia i?iyaeythony i?aeiouanoaaiii nieaeaieai oanoinoa?iia e o /anoe aieueiuo – iiauoaieai yno?aaeeiea. Ioia/aii, /oi eeeie/aneee iieeii?oeci oi?i e aa?eaioia oa/aiey o?iie/aneeo a?o?eoia ii?aaeaeyaony aaoa?iaaiiinoueth eiioiieiae/aneeo ia?ooaiee, eioi?ua iinyo aooieiioiiie oa?aeoa? e a oeaeii i?e eaaeaeie iicieiae/aneie oi?ia oa?aeoa?ecothony eeioioeeoa?iui aeenaaeainii, eiioii?aaoeyoi?iuie naeaeaaie, aeaoeoeeoii O-eeioioeeoia e aeoeaaoeeae A-nenoaiu eiioieoaoa. Iieo/aiu iiaua aeaiiua i cia/eiinoe aaiaoe/aneeo oaeoi?ia a ?acaeoee thaaieeueiiai o?iie/aneiai e ?aaeoeaiiai a?o?eoia. Aeieacaii, /oi thaaieeueiue o?iie/aneee e ?aaeoeaiue a?o?eo ioiinyony e caaieaaaieyi n ianeaaenoaaiiui i?aae?aniieiaeaieai. Ooi/iaiu annioeeaoeee caaieaaaiee, aa?eaioia eo oa/aiey n aioeaaiaie nenoaiu HLA e aea?iaoiaeeoe/aneeie iieacaoaeyie. Ii?aaeaeaii, /oi ia?ea?ii thaaieeueiiai o?iie/aneiai a?o?eoa yaeyaony A3, A28, A40; ?aaeoeaiiai a?o?eoa – A10, A8. Auyaeaii iaaaeiaiea aea?iaoiaeeoe/aneiai ?enoiea ia iaeueoeao e eaaeiiyo o eeoe iaiaai iiea, iniaaiii i?e thaaieeueiii o?iie/aneii e thaaieeueiii ?aaiaoieaeiii a?o?eoao. ?anoe?aiu i?aaenoaaeaiey i iaoiaaiaoe/aneeo iaoaieciao o?iie/aneeo a?o?eoia o iiae?inoeia. Ia iniiaaiee i?iaaaeaiiuo enneaaeiaaiee e iiiaiia?iiai noaoenoe/aneiai aiaeeca iieo/aiu aeieacaoaeuenoaa cia/eiinoe iniaaiiinoae acaeiiaeaenoaey aaiaoe/aneeo oaeoi?ia, eiioiieiae/aneeo iieacaoaeae, iieiauo noa?ieaeia, eeciniiaeueiuo oa?iaioia a ia?ooaieyo iaoaaieecia niaaeeieoaeueii-oeaiiuo no?oeoo? i?e eaaeaeie iicieiae/aneie oi?ia. Iainiiaaia eiioeaioeey ?acaeoey thaaieeueiiai o?iie/aneiai a?o?eoa. ?ac?aaioai aeeooa?aioeeaeueii- aeeaaiinoe/aneee aeai?eoi aeey o?iie/aneeo a?o?eoia ?acee/iie i?e?iaeu, a oaeaea e?eoa?ee i?iaiica oa?aeoa?a oa/aiey thaaieeueiiai o?iie/aneiai a?o?eoa e ?aaeoeaiiai a?o?eoa n eniieueciaaieai eeeie/aneeo i?eciaeia, iieacaoaeae eiioiiaaiaca, iaiaia niaaeeieoaeueii- oeaiiuo no?oeoo?. N o/aoii iieo/aiiuo aeaiiuo ia iniaaiiinoyo eeeie/aneie yaiethoeee o?iie/aneeo a?o?eoia e iaoiaaiaoe/aneeo iaoaieciao eo ?acaeoey aianaiu i?aaeeiaeaiey ii aeeooa?aioee?iaaiiiio ea/aieth iiae?inoeia. Iainiiaaii i?eiaiaiea iaaeeeaiaioiciuo n?aaenoa n ?acee/iui iaoaieciii aicaeaenoaey ia iaoieiae/aneee i?ioeann i?e thaaieeueiii o?iie/aneii e ?aaeoeaiii a?o?eoao, ooi/iaiu n?iee ea/aiey. ?anniio?aiu iniiaiua i?eioeeiu iacia/aiey iaiaaeeeaiaioiciuo iaoiaeia i?e ia?aaiaoieaeiuo a?o?eoao. Aianaiu ei??aeoeau a ea/aiea thaaieeueiiai ?aaiaoieaeiiai a?o?eoa. Eniieueciaaiu iniiaiua i?eioeeiu ainnoaiiaeoaeueiiai ea/aiey : eiaeeaeaeoaeueiinoue e yoaiiinoue – noaoeeiia? – iieeeeeieea – naiaoi?ii-eo?i?oiue yoai. ?ac?aaioaiu e?eoa?ee yooaeoeaiinoe oa?aiee aieueiuo e i?iaaaeaia eioaa?aeueiay ioeaiea ?acoeueoaoia ea/aiey. Ii?aaeaeaiu iniiaiua i?eioeeiu aeeniaina?iiai iaaethaeaiey iiae?inoeia n caaieaaaieyie nonoaaia ?acee/iie i?e?iaeu n ?ac?aaioeie ia?ii?eyoee ii i?aaeoi?aaeaeaieth iaino?aiee iaoieiae/aneiai i?ioeanna i?e eaaeaeie iicieiae/aneie oi?ia. Eeth/aaua neiaa: iiae?inoee, o?iie/aneea a?o?eou, eeeieea, iieiaua noa?ieaeu, nenoaiu eiioieoaoa, ianeaaenoaaiiinoue, iaoaaieeci niaaeeieoaeueiie oeaie, aeeooa?aioeeaeueiay aeeaaiinoeea, ea/aiea, aeeniaina?iia iaaethaeaiea. Lebets I.S. Peculiarities of the ?resent-day Course of Chronic Arthrites in Adolescents (clinical picture, diagnosis, therapy). Manuscript. Competitive Thesis for the Degree of Doctor of Science (Medicine). Speciality 14.01.10 – Pediatrics. Kharkiv State Medical University, Kharkiv, 1999. The work presents the results of studying adolescents with inflammatory lesions of the joints. It gives description of initial manifestations, evolution of clinical symptoms, and outcome of JCA, JRA, RA and ankylosing spondylarthritis. There have been analyzed certain peculiarities of the course of the disease in teen –agers at their various stages of puberty. Most characteristic disorders in the metabolism of connective tissue structures, in microcirculation, in immunity systems, and in sex steroid contents have been determined for various clinical forms of chronic arthrites (CA). New data on the genetic factor significance in the CA development and on their associations with genetic markers, as well as on the role of relationships between sex steroids, immunologic findings, connective tissue components and genetic markers have been obtained. There has been proposed a conception of JCA development. Criteria for differentially diagnosing CA of various origin and predicting the severity of their course have been worked out; propositions on differential treatment of adolescents have been presented. Certain criteria regarding therapy effectiveness have been developed, and its integral evaluation has been performed. There have been defined the basic principles of clinical observation of teen-agers with articular diseases of various etiology including treatment-and-sanitary measures aimed at preventing pathological process getting aggravated for each nosologic form. Key words: adolescents, chronic arthrites, clinical picture, sex steroids, immunity systems, heredity, connective tissue metabolism, differential diagnosis, treatment. IA?AE?E NEI?I*AIUe AN - aieeeicoth/ee niiiaeeeia?o?eo AE - A-e?ioioeeoe AAA - ae?eiciai?iiae?eaie Ae - aea?iaoiae?o?/i? iieacieee: ab - a?aaaiaaee ?aooiie TRC - caaaeueiee a?aaaiaaee ?aooiie A - ano?aae?ie Ig - ?ioiiaeiaoe?ie EE - e?aaoeie?iaca EO - eenea oinoaoaca Eo - eoaeia oinoaoaca IICI - ianoa?i?aei? i?ioecaiaeuei? i?aia?aoe IA - inoaia?o?ic IEN - ienei?ie?i ?C - ?aaiaoe/i? caoai?thaaiiy ?aA - ?aaeoeaiee a?o?eo NO - niieo/ia oeaieia NI50- eiiieaiaio O - oanoinoa?ii OE - O-e?ioioeeoe OA – o?ii?/i? a?o?eoe O - oiiae?i?oeinoeueoaoe Oe?E - oee?eoethth/? ?ioii? eiiieaene TH?A - thaai?eueiee ?aaiaoi?aeiee a?o?eo THOA - thaai?eueiee o?ii?/iee a?o?eo F - oaeoi?

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