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Особливості сучасного перебігу хронічних артритів у підлітків (клініка, діагностика, лікування): Автореф. дис… д-ра мед. наук / І.С. Лебец, Харк. де

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE

OI?AA?NEOAO

EAAAOe ??eia Noaiai?aia

OAeE 616.72-002-031.2-053.5/6

INIAEEAINO? NO*ANIIAI IA?AA?AO

O?II?*IEO A?O?EO?A O I?AeE?OE?A

( EE?I?EA, Ae?AAIINOEEA, E?EOAAIIss )

14.01.10 – iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ioi?iie caei?ia’y ae?oae ? i?aee?oe?a IIC Oe?a?ie, i. Oa?e?a.

Iaoeiaee eiinoeueoaio:

* aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie

EINOTH??IA Aaeeia Ieeeo?aia, Oe?a?inueeee iaoeiai-aeine?aeiee
?inoeooo ioi?iie caei?ia’y ae?oae ? i?aee?oe?a, i.Oa?e?a, aieiaiee
iaoeiaee ni?a?ia?oiee.

Io?oe?ei? iiiiaioe:

* aeieoi? iaaee/ieo iaoe, i?ioani?

NOEA*IAA Aaeeia ?aai?aia, Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, i?ioani? eaoaae?e oaeoeueoaonueei? iaae?ao??? c iaaee/iith
aaiaoeeith;

*aeieoi? iaaee/ieo iaoe, i?ioani?, Caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie

?AAIIAA Ia?aa?eoa Aanee?aia E?einueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, caa?aeoaa/ eaoaae?e aini?oaeueii? iaae?ao???;

* aeieoi? iaaee/ieo iaoe, i?ioani?

Ae?EIAANUeEEE Ieeiea Iaaeiae/, Oe?a?inueeee iaoeiai-aeine?aeiee
?inoeooo aeeoy/i? eo?i?oieia?? ? o?c?ioa?ai??, IIC Oe?a?ie, i.?aiaoi??y,
aee?aeoi? ?inoeoooo.

I?ia?aeia onoaiiaa – ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII
Oe?a?ie, a?aeae?eaiiy aeeoa?aioe?eii? ae?aaiinoeee, i?io?eaeoeee ?
oa?ai?? caoai?thaaiue aioo??oi?o i?aai?a o ae?oae, i. Ee?a.

Caoeno a?aeaoaeaoueny “ 24 ” /a?aiy 1999a. i 12 aiae.

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04. i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC Oe?a?ie (310022,
i. Oa?e?a, i?. Eai?ia 4).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?.Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee “ 21 ” o?aaiy 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, aeioeaio Ia/a?aiei
E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oai?iae noaeia?a ( ON ) cia/ii iioe?ai? ?
/anoi ? i?e/eiith oei/aniai? iai?aoeacaeaoiino? ? ?aiiuei?
?iaae?aeecaoe?? oai?eo iieiaeiai a?eo (Ianiiiaa A.A. c niaao., 1997). O
inoaii? aeanyoe??//y niinoa??aa?oueny c?inoaiiy /anoioe ye caiaeueieo,
oae ? aeaaaia?aoeaieo o?aaeaiue iii?ii-?ooiaiai aia?aoo o an?o a?eiaeo
a?oiao, a oiio /ene? o ae?oae ? i?aee?oe?a (Iaeeoiaa I.E., 1991;
Aeieo?iaa I.A.,1997; Aiae?aaaa A.E. n niaao., 1998). ?acii c oei, o
oai?eo ia aoaiao noaoaaiai aeic??aaiiy, a ia??iae? iae?i-aiaeie?eiii?
ia?aaoaeiae i?aai?cio, ui noi?iaiaeaeo?oueny iniaeeainoyie
ooieoe?iioaaiiy a?eueoino? i?aai?a ? nenoai, ON – iaeiaio aea/ai?
(Einoth?eia A.I. n niaao., 1997 ). Ia?aaeon?i oea a?aeiineoueny aei
thaai?eueiiai o?ii?/iiai a?o?eoo (THOA), yeee ca?aeii c no/aniith
I?aeia?iaeiith eeaneo?eaoe??th ?aaiaoe/ieo caoai?thaaiue (?C) aeae?eaiee
a ie?aio ?oa?eeo. Aei oeueiai /ano ia anoaiiaeaii, /e ? THOA ie?aiith
iicieia?/iith oi?iith aai yaey? ca??io a?oio oai?ia ?c noiaeith
ee?i?/iith neiioiiaoeeith ? aeei?enoiao?oueny o ?ac? iaiiaeeeaino?
anoaiiaeaiiy iaeaaeiino? aei eiie?aoii? iicieia?/ii? oi?ie (Eocueieia
I.I., 1995; Oaeeia A.A., 1995; Prier A.M., 1993 ). Ia?aeiieea? aeieace
a?aeiinii i?aaii??iino? oaeeo oyaeaiue ia iniia? o?eaaeeo ee?i?/ieo
niinoa?aaeaiue ? ia?aee?i?/ieo aeine?aeaeaiue a?aenooi?. Noiae?noue,
iniaeeai ia ?aii?o aoaiao ?icaeoeo, a ee?i?/i?e neiioiiaoeoe?
noaeiaiaiai neiae?iio i?e THOA ? thaai?eueiiio ?aaiaoi?aeiiio a?o?eo?
(TH?A), ?aaeoeaieo a?o?eoao ( ?aA ), aie?eicoth/iio niiiaeeeia?o?eo? (
AN ), a ?iiae? e aeaaaia?aoeaieo i?ioeanao i?e a?aenooiino?
ae?aaiinoe/ieo ? aeeoa?aioe?aeueii-ae?aaiinoe/ieo e?eoa???a aeey
a?eueoino? aeacaieo caoai?thaaiue a i?aee?oeiaiio a?oe? oo?oaeiy?
nai?/anio ae?aaiinoeeo, ca?eueoo? no?iee anoaiiaeaiiy i?aaeeueiiai
ae?aaiico ? i?ecia/aiiy aaeaeaaoii? oa?ai?? a?ae aeae?eueeio i?nyoe?a
aei ?ieo ? a?eueoa, ui ni?ey? oi?ioaaiith oyaeeeo, i?ia?anoth/eo
aa??aio?a ia?aa?ao ? iani?eyoeeaeo iane?aee?a noaeiaiai? iaoieia??
(Ieeeoeia E.I. n niaao., 1996; Ai?eniaa O.I. n niaao., 1997; Amor B. et
al, 1989 ).

Aeine?aeaeaiiy inoaii?o ?ie?a ia o?eueee noaee iniiaith aei ci?ie
no?oeoo?e eeaneo?eaoe?? ?C, o oiio /ene? caoai?thaaiue noaeia?a a
aeeoy/iio ? i?aee?oeiaiio a?oe?, aea ? aecia/eee ?yae ni??ieo ?
iaae??oaieo ieoaiue, ui noinothoueny iaeii??aeiino? ie?aieo ee?i?/ieo
oi?i ? aa??aio?a ia?aa?ao TH?A. Aeeneooothoueny ieoaiiy: an? oi?ie TH?A
– ?aeeia caoai?thaaiiy /e naiino?ei? oai?iae. Iniaeeao i?iaeaio a
thiaoeueeiio a?oe? noaiiaeyoue ?aaeoeai? a?o?eoe, i?e yeeo iaei aea/ai?
aaiethoe?y noaeiaiaiai neiae?iio ? iane?aeee (Nie?iia A.N. n niaao.,
1990; Aeaenaaaa A.E. n niaao.. 1998, Fernandes-Vina M.A., 1990).

Cia/ou?noue ?ioiii? nenoaie a ?icaeoeo ?C, a oiio /ene? oai?ia
noaeia?a ? ?ieue ?ioiiiaoieia?/ieo i?ioean?a a o?aaeaii? niieo/ii?
oeaieie ( NO ) a?aeii? (Ianiiia A.E.,1994; Maerker-Alser G., 1990;
Romagnoli P. et al, 1992;Harris E.D., 1993 ). Iaeiae o i?aee?oe?a oe?
aniaeoe noaeiaiai? iaoieia?? aea/ai? iaaeinoaoiuei, iniaeeai i?e
THOA. ?o ?ica’ycaiiy aeicaieeei a ?ice?eoe ?ioeii? iaoai?cie oi?ioaaiiy
ia o?eueee THOA, aea TH?A, ?aA oa ?ioeo o?ii?/ieo a?o?eo?a (OA), a
oaeiae io?eiaoe iaai? aeieace a?aeiinii naiino?eiino? ? iaeii??aeiino?
ye iicieia?/ieo oi?i THOA ? TH?A.

Ieoaiiy noaoaai? aeaoa?i?iaoe?? ?C oa ?nioth/ee aeaiiai?aaeaiee
ca’ycie i?ae ?ioiiith ? aiaeie?eiiith nenoaiaie, ia?aaeon?i noaoaaeie
ai?iiiaie (Blalok J.K., 1989; Straube M. et al, 1989; Amento E.P., 1993
) ia?aaeaa/athoue ?o ?ieue ? a noaeiaia?e iaoieia?? o i?aee?oe?a.
Aea/aiiy ee?i?/ii? neiioiiaoeee OA o oai?eo ia ??cieo aoaiao noaoaaiai
aeic??aaiiy c o?aooaaiiyi ii?ooaiue a ?ioiiaaiac?, c aieo noaoaaeo
noa?i?ae?a ni?eyei a ye iie?ioaiith ae?aaiinoeee caoai?thaaiue a
i?aee?oeiaiio a?oe?, oae ? ooi/iaiith aaaeeeaeo eaiie iaoiaaiaco aeaii?
iaoieia??.

O ?icaeoeo ?C cia/ia ?ieue a?aeaiaeeoueny aaiaoe/iei oaeoi?ai.
Iniiai? iai?yie aaiaoe/ieo aeine?aeaeaiue oi?eathoueny ?ie? niaaeeiaino?
? na?aaeiaeua a aeaoa?i?iaoe?? caoai?thaaiue, aaiaoe/ii? no?oeoo?e
noeeueiino? oa ?? aca?iiae?y c ee?i?/iei iie?ii?o?ciii, anoaiiaeaiiy
oeio oniaaeeoaaiiy ? anioe?aoe?e aaiaoe/ieo ia?ea??a c oai?iaith
(Aaiaaieaineay E.E., 1989; Neaeaeueieeiaa N.I., 1991; Rahman M.U. et
al,1993; Walder R.L.,1993). Iaeiae i?e oaeeo caoai?thaaiiyo, ye THOA,
TH?A ? ?aA a i?aee?oeiaiio a?oe? iiae?ai? aeine?aeaeaiiy ia/eneaii?,
aeeiiai? o ??cieo iiioeyoe?eieo a?oiao ? nooo?ai a?ae??ciythoueny ca
?acoeueoaoaie. ?acii c oei, aeai? o oe?e aaeoc? iiaee a ni?eyoe
?icoeo?iaoe? noo? caoai?thaaiue, a?eueo /?oeiio aecia/aiith ?o
no?oeoo?e, ?icoe?aiith ae?aaiinoe/ieo iiaeeeainoae ? iie?ioaiith
i?iaiico.

E?eoaaiiy ON ? iaei??th ?c neeaaeieo i?iaeai i?aee?oeiai?
?aaiaoieia?? a ca’yceo c ??ciiiai?ooyi iicieia?/ieo oi?i c o?aaeaiiyi
noaeia?a, ee?i?/iei iie?ii?o?ciii, aeanoeaei a?eueoino? caoai?thaaiue,
iaaeinoaoiueith ?o aea/ai?noth. Iaea?eueo ?ic?iaeai? ieoaiiy e?eoaaiiy
TH?A. Cia/ia ?icoe?aiiy a?naiaeo aioe?aaiaoe/ieo cania?a ? iaeiie/aiiy
aeina?aeo ?o ee?i?/iiai canoinoaaiiy aeicaieeei ?noioii oaeineiiaeeoe
i?eioeeie ? iaoiaee oa?ai?? oe??? aaaeei? iaaeoae (Ianiiia A.E., 1996;
Ae?eiaanueeee I.I. ?c ni?aaao., 1997;.Eiaaeaiei A.I, 1997; Oaoaacyi E.A.
n niaao., 1997; A?oaiiiiaa A.O. n niaao., 1998; oa ?io. ). ?acii c oei,
? i?e oe?e iicieia?/i?e oi?i? ia ae??oai? ieoaiiy, ui noinothoueny
aeai?o i?aia?ao?a i?e ie?aieo ee?i?/ieo aa??aioao, iaiao?aeiino?
o?eaaeiai canoinoaaiiy aacenieo ? ai?iiiaeueieo i?aia?ao?a, ui cia/ii
cieaeo? iiaeeeaino? a?eueo ni?eyoeeaeo iane?aee?a caoai?thaaiiy.
Aeuacaaaeaia na?ae/eoue i?i iaaee/io ? nioe?aeueio cia/ou?noue aeaii?
iaoieia?? a i?aee?oeiaiio a?oe? ? aecia/a? aeooaeuei?noue i?iaeaie ?
i?iaaaeaiiai aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.
Aeena?oaoe?eia ?iaioa aeeiioaaeany a ?aieao nithcieo, ?anioae?eainueeeo
i?ia?ai (AeEIO ), aeainoi?iiiuei? i?aeia?iaeii? ni?ai?aoe? c Iieueuath ?
aoea o?aaiaioii oaeeo eiiieaenieo IAe?: “Aaeineiiaeaiiy iaoiae?a
?aiiueiai aeyaeaiiy ? ?aaa?e?oaoe?? i?aee?oe?a ?c caoai?thaaiiyie
noaeia?a, nenoaiiei /a?aiiei aia/aeii ? ?aaiaoeciii ia iniia? aea/aiiy
ee?i?ei-iaoiaaiaoe/ieo iniaeeainoae ?icaeoeo c iaoith i?aeaeuaiiy yeino?
?aaiaoieia?/ii? aeiiiiiae o aeaiiio a?eiaiio ia??iae?” ( iiia?
aea?aeaaii? ?a?no?aoe?? – 01.88.0069576, oeo? NI.19.14.00 12.88) ?
“E?eoaaiiy i?aee?oe?a, oai?eo ia caiaeuei? caoai?thaaiiy noaeia?a, ia
noaoe?iia?iiio, iie?ee?i?/iiio ? naiaoi?iiio aoaiao“ (iiia? aea?aeaaii?
?a?no?aoe?? – 3.0193 02964100, oeo? 01.05.00/005-93 ).

Iaoa ?iaioe – aaeineiiaeaiiy iaoiae?a ae?aaiinoeee, e?eoaaiiy ?
aeeniaina?iiai niinoa?aaeaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe.

A?aeiia?aeii aei oe?eueiai? onoaiiaee aoee aecia/ai? ianooii?
caaea/?:

1. Aea/eoe iniaeeaino? ii/aoeiaeo ee?i?/ieo i?iya?a, aaiethoe?th
neiioiiaoeee ? iane?aeee o?ii?/ieo a?o?eo?a ??cii? i?e?iaee o i?aee?oe?a
c o?aooaaiiyi ia??iaeo noaoaaiai aeic??aaiiy.

2. Aeine?aeeoe o i?aee?oe?a noai iaoaaie?cio niieo/ii-oeaieiieo
no?oeoo?, i?e?ioee?eoeyoe??, ie?aieo eiiiiiaio?a ?ioiii? nenoaie ? ai?no
noaoaaeo noa?i?ae?a i?e ??cieo ee?i?/ieo oi?iao o?ii?/ieo a?o?eo?a.

3. Aecia/eoe ?ieue aaiaoe/ieo oaeoi??a o ?icaeoeo thaai?eueiiai
o?ii?/iiai ? ?aaeoeaiiai a?o?eo?a ? ooi/ieoe anioe?aoe?? o?ii?/ieo
a?o?eo?a c aaiaoe/ieie ia?ea?aie.

4. C’ynoaaoe aca?iica’ycie noaoaaeo noa?i?ae?a, ?ioiieia?/ieo
iieaciee?a, eiiiiiaio?a niieo/ii? oeaieie ? aaiaoe/ieo ia?ea??a o
?icaeoeo o?ii?/ieo a?o?eo?a.

5. ?ic?iaeoe e?eoa??? aeeoa?aioe?aeueii? ae?aaiinoeee a?o?eo?a
??cii? i?e?iaee ? i?iaiicoaaiiy oyaeeino? ?o ia?aa?ao.

6. Aeaoe i?iiiceoe?? uiaei aeeoa?aioe?eiaaiiai e?eoaaiiy
ia?aaiaoi?aeieo a?o?eo?a, ioe?ieoe eiai aoaeoeai?noue ? aianoe ei?aeoeae
o aeeniaina?ia niinoa?aaeaiiy i?aee?oe?a c aeaiith iaoieia??th.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aia?oa aeaia oa?aeoa?enoeea
iniaeeainoae ia?aa?ao ? iane?aee?a THOA ? ?aA o i?aee?oe?a ia ie?aieo
aoaiao noaoaaiai aeic??aaiiy. Anoaiiaeaii, ui a ?aiiueiio ioaa?oaoiiio
ia??iae? niinoa??aa?oueny iaea?eueo iai?oanoia neiioiiaoeea noaeiaiaiai
neiae?iio OA ? ae?aaeai?noue aenoaeaoeaiiai eiiiiiaioa caiaeaiiy.

Aia?oa i?e ia?aaiaoi?aeieo a?o?eoao o i?aee?oe?a aecia/aii
ii?ooaiiy iai?io niieo/ii-oeaieiieo no?oeoo? ? i?e?ioee?eoeyoe??.
Anoaiiaeaii, ui i?e THOA ? ?aA ia?aaaaeii iathoue i?noea ci?ie o
iaoaaie?ci? i?ioaiae?eai?a c ia?a?iciiae?eii o?aeoe?e AAA: ia?inoaiiyi
ai?noo oiiae?i?oei- 6, -4- ? aea?iaoainoeueoao?a o oai?eo ia THOA ?
oiiae?i?oei-6-noeueoao?a o i?aee?oe?a, oai?eo ia ?aA. I?e TH?A
aecia/athoueny neeaaei? ci?ie a iai?i? eieaaaio, i’yciai? oeaieie ?
i?ioaiae?eai?a ?c ca?eueoaiiyi I, III ? cieaeaiiyi II o?aeoe?? AAA. I?e
THOA ? TH?A aeyaeaia o?nia caeaaei?noue i?ae ii?ooaiiyie iaoaaie?cio
eieaaaio ? aeoeaaoe??th oa?iaioo eoaeii? oinoaoace, i?ioaiae?eai?a ?
eenei? oinoaoace. Ca?eueoaiiy a?aeoeeaiue o iaoaaie?ci? i?ioaiae?eai?a
ia? ca’ycie c aeoeaaoe??th a aoii?aeuei?e eaioe? ?ioi?oaoo.

Anoaiiaeaii, ui ia a?aei?io a?ae TH?A, i?e yeiio niinoa??aathoueny
iaea?eueo ae?aaeai? ? iioe?ai? ci?ie, ye? noinothoueny on?o eaiie
i?e?ioee?eoeyoi?iiai ?onea, o oai?eo ia THOA ia?aaaaeathoue noaeeii?, a
iaio?e i??? – aioo??oiueinoaeeii? ?iceaaee, o i?aee?oe?a, oai?eo ia ?aA
– noaeeii? ii?ooaiiy. I?e OA aoaeue-yei? i?e?iaee nooi?iue
i?e?ioee?eoeyoi?ieo ci?i ia?inoa? c aeoeai?noth iaoieia?/iiai i?ioeano.

Aeyaeaii, ui ?ioiieia?/i? cnoae i?e OA ?icaeaathoueny ia oii?
ii?ooaiue a oa?aeoa?? ?aaoethth/iai aieeao noaoaaeo noa?i?ae?a ia
?ioii? ?aaeoe??. O oeeo i?ioeanao i?e THOA ? ?aA ia? i?noea o?niee
ca’ycie ?c ano?aae?ieii; i?e TH?A – iaeii/anii c ano?aae?ieii ?
oanoinoa?iiii. I?e oeueiio, a?aeoeeaiiy ai?noo noaoaaeo ai?iii?a i?e
o?ii?/ieo a?o?eoao ??cii? i?e?iaee oa?aeoa?ecothoueny
iaeiiiai?aaeai?noth ? i?iyaeythoueny cieaeaiiyi oanoinoa?iio ?
i?aeaeuaiiyi ano?aae?ieo.

Aeiaaaeaii, ui THOA ? ?aA a?aeiinyoueny aei caoai?thaaiue ?c
niaaeeiaith noeeuei?noueth, iie?aaiiei oeiii oniaaeeoaaiiy. Aecia/aii
anioe?aoeai? ca’ycee i?ae aea?iaoiae?o?/ieie iieacieeaie, aioeaaiaie HLA
? caoai?thaaiiyie. Ia?ea?ii THOA ? A3, A28, A40; ?aA – A10, A8;
?aoeeaeeaoth/iai ia?aa?ao ?aA – N3,4. I?e OA o i?aee?oe?a anoaiiaeaii
ca?aeiaiiy aea?iaoiae?o?/iiai ?enoiea ia iaeueoeyo ? aeieiiyo.

Iiaeeaeaii oyaeaiiy i?i iaoiaaiaoe/i? iaoai?cie OA o i?aee?oe?a.
Ia iniia? i?iaaaeaieo aeine?aeaeaiue ? aaaaoii??iiai noaoenoe/iiai
aiae?co io?eiaii aeieace cia/ouino? noaoaaeo ai?iii?a, ?ioiiiaoieia?/ieo
cnoa?a, aeoeaaoe?? e?ciniiaeueieo ? oeeoie?oe/ieo oa?iaio?a, aaiaoe/ieo
oaeoi??a ? iniaeeainoae ?o aca?iica’yce?a a ii?ooaiiyo iaoaaie?cio
niieo/ii-oeaieiieo no?oeoo? i?e eiaei?e iicieia?/i?e oi?i?.

Aia?oa a i?aee?oeiaiio a?oe? ?ic?iaeaii
aeeoa?aioe?aeueii-ae?aaiinoe/iee aeai?eoi aeey o?ii?/ieo a?o?eo?a ??cii?
i?e?iaee, a oaeiae e?eoa??? i?iaiico ia?aa?ao THOA ? ?aA.

Aeaii i?iiiceoe?? uiaei aeeoa?aioe?eiaaiiai e?eoaaiiy
ia?aaiaoi?aeieo o?ii?/ieo a?o?eo?a. Aecia/aii iniiai? i?eioeeie
aeeniaina?iiai niinoa?aaeaiiy i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe, ?
ioe?iaii aoaeoeai?noue ?o e?eoaaiiy c o?aooaaiiyi canoinoaaiiy ?ic?iaie
i?ioyaii o?eaaeiai i?iniaeoeaiiai niinoa?aaeaiiy.

Ia iniia? aeaieo ee?i?/ii? neiioiiaoeee ia ?aii?o aoaiao ?icaeoeo,
o?eaaeeo eaoaiianoe/ieo niinoa?aaeaiue ee?i?/ii? aaiethoe?? noaeiaiaiai
neiae?iio, ci?i a ?ioii?e nenoai? ? iaoaaie?ci? niieo/ii-oeaieiieo
no?oeoo?, aeyaeaieo niaoeeo?/ieo aaiaoe/ieo ia?ea??a ? aaaaoii??iiai
noaoenoe/iiai aiae?co (oaeoi?iiai aiae?co), oaeoi?ii? iiaeae?
iaoiaaiaoe/ieo aca?iica’yce?a iieaciee?a anoaiiaeaii, ui THOA ?
naiino?eiith iicieia?/iith oi?iith. Iath/e ?yae ni?eueieo ee?i?/ieo ?en
c TH?A, THOA a?ae??ciy?oueny a?eueo ni?eyoeeaei ia?aa?aii ?
iane?aeeaie.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aeei?enoaiiy
io?eiaieo aeaieo i?i iniaeeaino? no/aniiai ia?aa?ao caiaeueieo
caoai?thaaiue noaeia?a o i?aee?oe?a, o oiio /ene? ia aoaiao noaoaaiai
aeic??aaiiy, a oaeiae aeeoa?aioe?aeueii-ae?aaiinoe/ieo aeai?eoi?a aeey
noiaeeo ca ii/aoeiaeie ee?i?/ieie i?iyaaie OA iie?ioeoue ?o ?aiith
ae?aaiinoeeo ? i?enei?eoue i?ecia/aiiy aaeaeaaoii? oa?ai??.

Canoinoaaiiy aeaieo a?aeiinii “oaeoi??a ?eceeo” aeey iaio
ni?eyoeeaeo aa??aio?a ia?aa?ao THOA ? ?aA ? aeai?eoio ?o i?iaiico
ni?eyoeia oia?aaeaeaiith ?aoeeaeeaoaaiiy iaoieia?/iiai i?ioeano ?
i?enei?eoue ianoaiiy ?ai?n?? ? iaeoaeaiiy.

Aeei?enoaiiy a?aeiiinoae i?i ?ieue n?iaeii? aa?aaaoe?? ?C,
anoaiiaeaieo anioe?aoe?e OA c iaaieie aaiaoe/ieie ia?ea?aie
(aea?iaoiae?o?/ieie, aioeaaiaie HLA ) i?aeaeueoue ??aaiue ae?aaiinoeee
aeaii? iaoieia??.

Ai?iaaaeaeaiiy a i?aeoeeo ioi?iie caei?ia’y ?ic?iaeaieo
aeeoa?aioe?eiaaieo eiiieaen?a e?eoaaiiy oai?eo ia OA ? aeai?eoio
ioe?iee eiai aoaeoeaiino? ni?eyoeia nai?/aniiio i?iaaaeaiith
aaeaeaaoieo e?eoaaeueieo caoiae?a, iiia?aaeaeaiith iaio ni?eyoeeaeo
aa??aio?a ia?aa?ao ? iane?aee?a caoai?thaaiue ? aoaea i??ith ?o
aoi?eiii? i?io?eaeoeee.

Iaa?oioiaaia iaiao?aei?noue aeeiai?/iiai niinoa?aaeaiiy i?aee?oe?a
c OA aeicaieeoue ia aoaiao ?o ?icaeoeo nai?/anii ooi/ithaaoe oa?aeoa?
aaiethoe?? iaoieia?/iiai i?ioeano, i?iaiaeeoe iaiao?aeio ei?aeoe?th
oa?ai??, ui iie?ioeoue iane?aeee aeaii? iaoieia??.

Iniaenoee aianie caeiaoaa/a. I?e i?iaaaeaii? aeine?aeaeaiue ii
aeena?oaoe?? aaoi?ii naiino?eii i?iaiaeeany a?aea?? ? niinoa?aaeaiiy
oai?eo a ee?i?oe? ? ia aiaoeaoi?iiio aoai?, cae?aiiy aeaieo i?i n?i’th,
neeaaeaiiy ?iaeiaiae?a, aaiaaeia?/iee ? naa?aaaoe?eiee aiae?ce,
aea?iaoiae?o?/i? aeine?aeaeaiiy ? ?ic?aooiie aea?iaoiae?o?/ieo
iieaciee?a, a?ii?e?ineii?y eii’thieoeae ia u?eeii?e eaii?, oi?ioaaiiy
eiii’thoa?ii? aace iaaooeo aeaieo, i?aeaioiaea iaoa??aeo aeine?aeaeaiue
aeey iaoaiaoe/ieo ?ic?aooie?a, eiai noaoenoe/ia ia?iaea, ?ioa?i?aoaoe?y
? oai?aoe/ia ocaaaeueiaiiy io?eiaieo ?acoeueoao?a, a oaeiae ?ic?iaea
aeeoa?aioe?aeueii-ae?aaiinoe/ieo aeai?eoi?a aeey ie?aieo iicieia?/ieo
oi?i, aeai?eoi?a i?iaiico iaio ni?eyoeeaiai ia?aa?ao THOA ? ?aA,
i?eioeei?a ?aaa?e?oaoe?? i?aee?oe?a, oai?eo ia o?ii?/i? a?o?eoe,
ei?aeoe?y oa?ai?? oai?eo ia noaoe?iia?iiio ? aiaoeaoi?iiio aoai?,
ioe?iea ?acoeueoao?a e?eoaaiiy, ai?iaaaeaeaiiy ?aeiiaiaeaoe?e
a?aeiia?aeii aei iniiaieo iieiaeaiue ? aeniiae?a ?iaioe, ia?iaea aeaieo
a?o/eciyii? ? ca?oa?aeii? e?oa?aoo?e. Aeei?enoiaoth/e aaaaoii??iee
noaoenoe/iee aiae?c, aaoi?ii noai?aia oaeoi?ia iiaeaeue iaoiaaiaoe/ieo
aca?iica’yce?a iieaciee?a aeey ??cieo OA ? eiioeaioe?y ?icaeoeo
thaai?eueiiai o?ii?/iiai a?o?eoo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Ca iniiaieie iieiaeaiiyie
?iaioe c?iaeaii aeiiia?ae? ia IV Ananithciiio c’?cae? ?aaiaoieia?a (
I?inuee, 1991), I?aeia?iaeiiio Neiiic?oi? ?aaiaoieia?a (Iineaa, 1986),
XVI Neiiic?oi? ?a?iiaenueeiai oiaa?enoaa inoaia?o?ieia?a (Iineaa,
1987), Ananithci?e eiioa?aioe?? ?aaiaoieia?a (Iineaa, 1988), II
c’?cae? ?aaiaoieia?a ?in?? (Iineaa 1997), Ieaioi? ?anioae?eainueeiai
oiaa?enoaa ?aaiaoieia?a (?aaii-O?aie?anuee, 1991), I ? II Eiia?an?
?aaiaoieia?a Oe?a?ie (Oa?iii?eue, 1993; Ee?a, 1997), I ? II c’?caeao
iaaee/ieo aaiaoee?a Oe?a?ie (Euea?a, 1988, 1995), Ananithciiio ?
I?aeia?iaeiiio neiiic?oiao aaiaoee?a (Oiaeueieoeueeee, 1988; Oa?e?a,
1994), ?anioae?eainueeiio neiiic?oi? (Iaeana, 1995), ?anioae?eainueeeo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo (Oa?e?a, 1990, 1992, 1993, 1995,
1996), ia can?aeaiiyo oiaa?enoaa ?aaiaoieia?a ? aeeoy/eo e?ea??a OIIO
(1988-1998).

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeothoueny a ee?i?oe? ?
eiinoeueoaoeai?e iie?ee?i?oe? Oe?a?inueeiai IAe? ioi?iie caei?ia’y
ae?oae ? i?aee?oe?a, aeeoy/eo a?aeae?eaiiyo ?aeiiieo ? iaeanieo
e?ea?aiue ? i?aee?oeiaeo eaa?iaoao iie?ee?i?e Oa?e?anueei?,
Iieoaanueei?, Noinueei?, Eoaainueei?, E??iaia?aaenueei?, Euea?anueei?,
?aaii-O?aie?anueei?, Ieeiea?anueei?, *a?i?aaoeueei? iaeanoae,
?anioae?ee E?ei.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue iioae?eiaaii 2 iaoiaee/i?
?aeiiaiaeaoe??, ?ic?iaeaii aeai?eoie aeeoa?aioe?aeueiiai ae?aaiico,
i?iaiico iani?eyoeeaiai ia?aa?ao caoai?thaaiue, ioe?iee aoaeoeaiino?
e?eoaaiiy. ?acoeueoaoaie ai?iaaaeaeaiiy ? i?aeaeuaiiy yeino?
ae?aaiinoeee, caiia?aaiiy o?ainoi?iaoe?? caoai?thaaiue a a?eueo oyaee?
aa??aioe ia?aa?ao, a oaeiae ?icaeoeo ?iaae?aeecaoe?? i?aee?oe?a.

Oai?aoe/i? iieiaeaiiy ? i?aeoe/i? ?aeiiaiaeaoe??, aeeeaaeai? a
aeena?oaoe?ei?e ?iaio?, aeei?enoiaoaaeeny i?e /eoaii? eaeoe?e ia eo?nao
noaaeoaaiiy ? ?ioi?iaoe?? aeey ea?ae?i?aaiaoieia?a, iaae?ao??a,
oa?aiaao?a i?aee?oeiaeo eaa?iao?a, ia eaoaae?ao oaeineiiaeaiiy e?ea??a,
a oaeiae a eaeoe?eiiio eo?n? aeey nooaeaio?a Oa?e?anueeiai aea?aeaaiiai
oi?aa?neoaoo.

Ioae?eaoe??. Ca ?acoeueoaoaie aeena?oaoe?? iioae?eiaaii 48
iaoeiaeo ?ia?o, o oiio /ene?: a aeo?iaeao – 18 ( 17 c ieo a aeo?iaeao
AAE Oe?a?ie), a iaoeiaeo ca??ieeao- 10, ?aooa – oace ? iaoa??aee
neiiic?oi?a, eiia?an?a, c”?cae?a, eiioa?aioe?e.

Ianya oa no?oeoo?a ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 327
noi??ieao iaoeiiieno, ?ethno?iaaia 46 oaaeeoeyie, 20 ?enoieaie ?
aeeth/a? anooi, iaeyae e?oa?aoo?e ( 2 ?icae?ee), aeani? aeai? oa ?o
iaaiai?aiiy ( 11 ?icae?e?a ), aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??. Nienie
aeei?enoaieo aeaea?ae e?oa?aoo?e aeeth/a? 546 iaeiaioaaiue, a oiio
/ene? 160 ?ia?o aaoi??a aeaeaeiai ca?oa?aeaey.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. C 1986 ii 1998 ?iee i?ae
niinoa?aaeaiiyi ciaoiaeeeiny 343 i?aee?oee 10 – 18 ?ie?a. Na?aae ieo
c iaoieia??th noaeia?a aoei 69 oai?eo ia THOA, 89 – TH?A, 119 – ?aA, 23
– aie?eicoth/ee niiiaeeeia?o?eo (AN). A?oio ii??aiyiiy noaiiaeee 43
i?aee?oee, oai?? ia inoaia?o?ic.

C iaoith iinoaaeaiiy ae?aaiic?a ea?oaaeeny no/aniith I?aeia?iaeiith
eeaneo?eaoe??th ?C, eeaneo?eaoe??th thaai?eueiiai ?aaiaoi?aeiiai a?o?eoo
(1980), No?aeii?a?iiaenueeeie ae?aaiinoe/ieie e?eoa??yie TH?A ( 1979 ),
e?eoa??yie A?A aeey AN ? e?eoa??yie ae?aaiinoeee IA, ?ic?iaeaieie
ni?a?ia?oieeaie ?inoeoooo ?aaiaoieia?? AII eieeoiueiai N?N? ( 1983 ).

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aiae?coaaeeny c o?aooaaiiyi
ianii?oiiai a?eo ? nooiaiy a?ieia?/ii? c??eino? oai?eo ( i?aioaa?oao,
?aii?e ioaa?oao, aeania ioaa?oao ).

Aea/aii aeaatho, ee?i?/io neiioiiaoeeo oa ?? aaiethoe?th a i?ioean?
o?eaaeiai ( 7-10 ?ie?a ) niinoa?aaeaiiy, ?aioaaiieia?/i? ci?ie a
iii?ii-?ooiaiio aia?ao? ? iane?aeee caoai?thaaiue noaeia?a, iniaeeaino?
?o ia?aa?ao ia aoaiao noaoaaiai aeic??aaiiy i?aee?oe?a.

Aeey ooi/iaiiy nooiaiy caiaeueieo ci?i, ia??ai? c ee?i?/iei
aiae?cii e?ia?, i?iaiaeeeiny aecia/aiiy na?iioei?aeo, ae?eii?ioa?ae?a,
n?aeiaeo eeneio, N- ?aaeoeaiiai a?eea, i?ioa?iia?aia. E??i oiai,
aeei?enoai? caaaeueiii?eeiyo? ee?i?/i? e?eoa???, ui oa?aeoa?ecothoue
nooi?iue caiaeueiiai i?ioeano a noaeiaao a aaeao: o?eaae?noue ?aieiai?
neooino?, /enei noaeia?a c aenoaeaoii, ?iaeaen i?eiooeino?, noaeiaiaee
?iaeaen, aieth/?noue a noaeiaao i?e ianeaiiio ?on? a ieo, /enei
aeoeaieo noaeia?a.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee aea/aiiy iieaciee?a
ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo. O – eaieo ?ioi?oaoo
aeine?aeaeoaaee oeyoii aecia/aiiy a?aeiinii? e?eueeino? O-e?ioioeeo?a
(A-?OE) a ia?eoa?e/i?e e?ia? ?aaeoe??th niiioaiiiai ?icaoeiooai?aiiy (
Jondae M. at al., 1972), ooieoe?iiaeueio aeoeai?noue O- e?ioioeeo?a
aecia/aee ca oanoaie aeanoo?ainoi?iaoe?? (?AOE) c o?oiaaiaaethoeieiii
(OAA), noaiiioeyoe?? O-e?ioioeeo?a – ca aeiiiiiaith oaio?e?iiai? i?iae
(Shore et al,1978). A – e?ioioeeoe (AAN-?OE) aecia/aeeny ?aaeoe??th
?icaoeiooai?aiiy c e?ioioeeoaie, nainea?e?ciaaieie aioene?iaaoeith aei
a?eo?ioeeo?a aa?aia (Bianco et al, 1970),. ??aaiue ?ioiiaeiaoe?i?a
ne?iaaoee e?ia? aeine?aeaeaiee iaoiaeii i?inoi? ?aae?aeueii?
?ioiiaeeooc?? ca G. Manchini (1965 ), oee?eoethth/? ?ioii? eiiieaene (
Oe?E ) – niaeo?ioioiiao?e/iei iaoiaeii ?c aeei?enoaiiyi ?ic/eio IYA
(No?o/eia I.O.n niaao., 1985). Eiiieaiaioa?ia aeoeai?noue ne?iaaoee
e?ia? aecia/aeany ca 50% aaiie?cii. Oaaioeeoa?ia eaiea ?ioi?oaoo
thoe?ithaaeanue ca aeiiiiiaith aecia/aiiy oaaioeeoa?iiai /enea oa
oaaioeeoa?iiai ?iaeaeno eaeeioeeo?a (Ianoa? A.O. n niaao. 1989).

Ai?no noaoaaeo noa?i?ae?a, oanoinoa?iio ? ano?aae?ieo,
e?aaoeie?iace, i?iaeia?io, eaeueoeeoii?io, aioeo?e aei AeIE
aeine?aeaeoaaeiny ?aae?i?ioiieia?/iei iaoiaeii c aeei?enoaiiyi iaai??a
noaiaea?oieo ?aaeoea?a ca?oa?aeieo o??i: Amersham ( Aiae?y ),
Pharmacia Diagnostik ( Oaaoe?y ), International CIS (O?aioe?y ),
Mallinckrodt Diagnostica ( I?ia//eia ), Diagnostic System Laboratories
INC ( NOA ), OII ? AIOA I?A ( I?inuee ).

Aeey ioe?iee iaoaaie?cio NO aecia/aeeny ae?eiciai?iiae?eaie ca
iaoiaeii ?.I.Ooa?i ?c ni?aaao. ( 1982 ), ienei?ie?i a na/? ca
iaoiaeeeith A.A.E?aeue ?c ni?aaao. (1968 ), caaaeuei?
oiiae?i?oeinoeueoaoe – ?aaeoe??th c ?eaaiieii, o?iiia? eeneioe – ca
iaoiaeeeith ?.A Ia?eo?’?ai? ?c ni?aaao.( 1974 ), aene?aoe?y eaeueoe?th
c na/ath, eenea oinoaoaca, eoaeia oinoaoaca – ca oi?o?eiaaieie
iaoiaeeeaie.

Noai i?e?ioee?eoeyoe?? aea/aiee ca iaoiaeii a?ii?e?ineii??
eii’thieoeae ia u?eeii?e eaii? UE-56 i?e ca?eueoaii? a 18 – 60 ?ac?a.
Aeei?enoaii e?euee?nii- ye?ni? e?eoa??? ioe?iee ia?eoa?e/iiai e?iaiia?ao
ca iaoiaeii I.A.Ooeuei?ii? (1979 ) ? ?.O.Einothe ( 1981 ).

Aaiaoe/i? aeine?aeaeaiiy aeeth/aee cae?aiiy aeaieo i?i n?i’th,
neeaaeaiiy ?iaeiaiae?a, aaiaaeia?/iee ? naa?aaaoe?eiee aiae?ce,
aea?iaoiae?o?eo. Aea/aii iniaeeaino? ia?aa?ao caoai?thaaiue ?c
o?aooaaiiyi iaoyaeaii? niaaeeiaino? ii ?C. I?e aiae?c?
aea?iaoiae?o?/ieo iieaciee?a aeei?enoaii iaoiaeeeo I.Cummis, C. Midlo (
1961 ), ioe?iaii 49 e?euee?nieo ? ye?nieo iciae ia e?a?e ? i?aa?e ?ooe?
ia??cii. Aeei?enoaii ?iaeaene Aeaieiaea?a, Oo?oaaoa ? Iiea.

Niaoeeo?/i?noue HLA aecia/aeany ca aeiiiiiaith noaiaea?oiiai
aeainooiaiaaiai e?ioioeeoioiene/iiai oanoo Oa?anae?. Aeei?enoaii
a?noioeioth/o iaiaeue aioe – HLA – ne?iaaoie ae?iaieoeoaa Naieo –
Iaoa?ao?cueeiai IAe? aaiaoieia?? ? ia?aeeaaiiy e?ia?, yea i?noeoue
iiii-, ae? – ? o?eniaoeeo?/i? aioene?iaaoee aei aioeaai?a HLA ia?oiai
eeano eieon?a A, A, N.

Aeey eiio?ieth aoa aeei?enoaiee ??aaiue iieaciee?a, ?ic?iaeaiee o
a?aeiia?aeieo eaai?aoi??yo ?inoeoooo.

E?eoaaiiy oai?eo i?iaiaeeeiny a noaoe?iia?? Oe?a?inueeiai IAe?
ioi?iie caei?ia’y ae?oae ? i?aee?oe?a, iaaeae? cae?enithaaeiny
aiaoeaoi?ii, a o /anoeie oai?eo – a naiaoi??? “Cae?aaieoey” i. ?aiaoi??y
? i?noeaaiio ea?ae?i?aaiaoieia?/iiio naiaoi??? c ei?aeoe??th
oa?aiaaoe/ieo caoiae?a eiaei? 6 i?nyoe?a a oiiaao ee?i?ee aai
iie?ee?i?ee ?inoeoooo. Uiaei ioe?iee aoaeoeaiino? e?eoaaiiy aeei?enoaii
ee?i?/i? ? eaai?aoi?i? iieacieee, ui oa?aeoa?ecothoue nooi?iue
caiaeueiiai i?ioeano ? oa?aeoa? eiai i?ia?anoaaiiy.

I?e ?ic?iaoe? aeai?eoi?a ae?aaiico ? i?iaiico caoai?thaaiue
noaeia?a canoiniaaii nenoaiii-?ioi?iaoe?eiee aiae?c ? iaoiaeeea
iaiaeii??aeii? iine?aeiaii? i?ioeaaeo?e Aaeueaea c aecia/aiiyi
?ioi?iaoeaiino? iciae ca aeiiiiiaith e?eoa??th Eoeueaaea.

Noaoenoe/ia ia?iaea io?eiaieo ?acoeueoao?a aeeiiaia ia
ia?niiaeueiiio eiii’thoa?? IAI ?N. Aeey aecia/aiiy aeinoia??iino?
a?aei?iiinoae iieaciee?a aeei?enoaii ia?aiao?e/i? ? iaia?aiao?e/i?
e?eoa??? Nouethaeaioa, A?eeieniia, O?oa?a. Aeey aeyaeaiiy oa?aeoa?o
aca?iica’yce?a i?ae iieacieeaie canoiniaaii ei?aeyoe?eiee aiae?c, a
oaeiae aaaaoii??iee noaoenoe/iee aiae?c – oaeoi?iee aiae?c ( iaoiae
aieiaieo eiiiiiaio, “varimax” iaa?oaiiy, ia/eneaiiy ?iaeea?aeoaeueieo
cia/aiue oaeoi?ieo aiane?a), (Aeaacyi N.A. n niaao.,1989). Aeei?enoaii
i?ia?aio Statgraphics’ plus 2.1 aeey Windows.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aea/aiiy aeaathoo ?
aaiethoe?? ??cieo ca i?e?iaeith o?ii?/ieo a?o?eo?a a i?ioean? 5 – 10
?ie?a i?iniaeoeaiiai niinoa?aaeaiiy i?aee?oe?a ? ?ao?iniaeoeaiee aiae?c
ee?i?/ii? neiioiiaoeee aeicaieeee aecia/eoe oa?aeoa?i? iniaeeaino?
no/aniiai ia?aa?ao oe??? iaoieia?? ? io?eiaoe aeai? a?aeiinii ??oaiiy
?yaeo aeeneon?eieo ieoaiue.

?acoeueoaoe aaaaoi??/iiai niinoa?aaeaiiy oai?eo ia THOA na?ae/eee
i?i oa, ui caoai?thaaiiy ia? ?yae iaaieo ee?i?/ieo ?en. O i?aee?oe?a
a aiaiiac?, ye i?aaeei, niinoa??aaeeny /ano? ?ioa?eo?aioi?
caoai?thaaiiy, aenieee ?ioaeoe?eiee ?iaeaen, aeyaeyeeny o?ii?/i?
aiaieua ?ioaeoe??, ia?aaeon?i oiicee?o ( 63,3 % ). Na?aae iiia?aaei?o
THOA /eiiee?a o 1/3 oai?eo cono??/aeany o?aaia noaeiaa, o /anoeie –
?ani??aoi?i? caoai?thaaiiy. O a?eueoino? oai?eo ca’ycie THOA c
yeei-iaaoaeue i?iaieoth/ei /eiieeii anoaiiaeoe ia aaeaeiny.

THOA oa?aeoa?ecoaaany i?aeaino?ei ia/aeii, iaaenieith aeoeai?noth ?
iiiiie?aia?oeeoey?ieie o?aaeaiiyie, ia?aaaaeii ci?iaie o eie?iieo (78,3
%) ? aii?eeiainoiiieeo ( 33,3 % ) noaeiaao, ??aeei – a noaeiaao aa?oi?o
e?ioe?aie. Aaea ia ii/aoeiaeo aoaiao oai?iae a?aecia/aeeny iaai?
caeiiii??iino? a ?? ?icaeoeo. Iaeaea o iieiaeie oai?eo ( 47,8 % ) iaei
i?noea caeo/aiiy aei iaoieia?/iiai i?ioeano ia?ieo noaeia?a, iaeiae,
neiao?e/ia o?aaeaiiy ae??aieo noaeia?a, ui niinoa??aa?oueny i?e TH?A,
aoei a?aenooi?. Ia a?aei?io a?ae TH?A, i?e THOA ??aeei ?icaeaaeeny ci?ie
a 4 ? a?eueo noaeiaao, ia aeyaeaii ?aieiai? neooino?, ao?neo?a,
o?aaeaiiy i?aaio ci?o. E??i oiai, i?e THOA, a ii??aiyii? c TH?A, ia
anoaiiaeaii aeano?oeoe?? e?noeiai? oeaieie. Eeoa o 23,2 % i?aee?oe?a
ia ?ai?oa i?ae /a?ac ??e a?ae aeaathoo a?o?eoo iaa i?noea inoaiii?ic,
aea i?ia?anoaaiiy ?aioaaiieia?/ieo ci?i a i?ioean? iiaeaeueoi?
aaiethoe?? oai?iae aoei a?aenooi?. Iacaaaeath/e ia cia/io o?eaae?noue
a?o?eoo (a na?aaeiueiio – 120,7 aei?a ), ae?aaeai?noue eiai aoea
iii??iith, o oiio /ene? nooi?iue iaa?yeeino? noaeia?a ? aieth/ino? a ieo
i?e aeoeaieo ? ianeaieo ?ooao. Noaeiaiaee neiae?ii i?e THOA iaa
noeeuei?noue aei ?aoeeaeeaoaaiiy, iniaeeai /anoi ia ae?oaiio ? o?aoueiio
?ioe? caoai?thaaiiy ( 42,6% ? 41,7% a?aeiia?aeii ). ?acii c oei,
aaiethoe?y noaeiaiaiai neiae?iio i?e THOA, iacaaaeath/e ia ia??iaee/ia
?aoeeaeeaoaaiiy iaoieia?/iiai i?ioeano, iaea aeia?iye?niee oa?aeoa? ? ia
e?iaoeue niinoa?aaeaiiy o a?eueoino? oai?eo (89,9 %) ianoaea no?eea
?ai?n?y c oe?eeiaeoei cieeiaiiyi iciae o?aaeaiiy noaeiaiaiai aia?aoo. A
oe?eiio, a?aenooi?noue ee?i?/ieo i?iya?a oai?iae i?ioyaii 5 ?ie?a ia
oii? oe?eeiaeoiai neanoaaiiy iaaeeeaiaioicii? oa?ai?? aoei iaie
?icoe?iaii ye aeaeoaeaiiy (26,0%). Ia iniia? aiae?co ee?i?/ii?
neiioiiaoeee aoee aeae?eai? ianooii? aa??aioe ia?aa?ao THOA: ??aeei
?aoeeaeeaoth/ee (66,7%) ? /anoi ?aoeeaeeaoth/ee (33,3%). ??aeei
?aoeeaeeaoth/ee ia?aa?a ia?aaeaa/aa ia??iaee/ia caaino?aiiy oai?iae c
e?euee?noth ?aoeeaeea?a ia a?eueoa 1 ?aco ca 2 ?iee, /anoi
?aoeeaeeaoth/ee – aa??aio caoai?thaaiiy c ?aoeeaeeaaie ui??/ii aai
a?eueo 1 ?aco ca ??e.

Aeyaeaii iniaeeaino? i?iya?a THOA o i?aee?oe?a c ??ciei ??aiai
a?ieia?/ii? c??eino?, ye? na?ae/eee i?i iaai? aiaeie?eii? aieeae ia
ee?i?/io neiioiiaoeeo caoai?thaaiiy o ??ci? ia??iaee ioaa?oaoo.
Anoaiiaeaii, ui iaea?eueo ae?aaeaia ee?i?ea a?o?eoo c yne?aaei
aenoaeaoeaiei eiiiiiaioii caiaeaiiy ? eiai /ano? ?aoeeaeeae
niinoa??aathoueny o ?aiiueiio ioaa?oaoiiio ia??iae?. O aeania
ioaa?oaoiiio ia??iae? ia?aaaaeaee ie?aia?oeeoey?i? o?aaeaiiy,
ciaiooaaeany nooi?iue ee?i?/ieo i?iya?a a?o?eoo ? eiai o?eaae?noue.

?ioiieia?/i? aeine?aeaeaiiy aeyaeee i?e THOA ii?ooaiiy a O- ? A
nenoaiao ?ioi?oaoo. Anoaiiaeaii o ii??aiyii? ?c caei?iaeie cieaeaiiy o
a?eueoino? oai?eo a?aeiinii? e?eueeino? O-e?ioioeeo?a (?
0,01 0,001) i?e TH?A, a ii??aiyii? c THOA. Oea aeaco? ia oa, ui i?e
TH?A niinoa??aa?oueny a?eueo o?nia aca?iiae?y i?ae aoii?aeueieie
oaeoi?aie ?ioi?oaoo ? i?ioaiae?eaiaie, a oaeiae ano?aae?ieii ?
O-e?ioioeeoaie. Inoaii?, i/aaeaeii, iineeth? aeenaaeain
?ioiieiiiaoaioieo ee?oei, aeiaea? ?ioiiiaoieia?/iei i?ioeanai a?eueo
aa?aneaiee oa?aeoa? noiniaii aieeao ia no?oeoo?e NO. O ?icaeoeo THOA ?
?aA, ca aeaieie ni?eueii? oaeoi?ii? iiaeae?, niinoa??aaeany noiae?noue a
i?ioeanao ii?ooaiiy iaoaaie?cio eieaaaio ia oii? i?aeaeuaiiai
aioeo?eiooai?thaaiiy ? aeoeaaoe?? eoaeii? oinoaoace (F1), o/ano?
ano?aae?ieo a aeoeaaoe?? A-eaiee ?ioi?oaoo (F2), ?icaeoeo eaoaaie?/ieo
i?ioean?a ia ??ai? i?ioaiae?eai?a e ?o ca’ycie c aeoeai?noth
aoii?aeueii? eaiee ?ioi?oaoo (F3). ?acii c oei, ii F1 ? F3 aeyaeaii
?noioi? noaoenoe/i? a?aei?iiino? (?

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