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Особливості клінічного перебігу та лікування цукрового діабету в учасників ліквідації наслідків аварії на Чорнобильській АЕС: Автореф. дис… канд. ме

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?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI

?i. A.I.Eii?na?aiea AII Oe?a?ie

AI?IIEI Aiae??e Aiaoie?eiae/

OAeE 616.379-008.64.-085:621.039.586-051

INIAEEAINO? EE?I?*IIAI IA?AA?AO OA E?EOAAIIss OeOE?IAIAI Ae?AAAOO A

O*ANIEE?A E?EA?AeAOe?? IANE?AeE?A AAA??? IA *I?IIAEEUeNUeE?E AAN

14.01.14 – aiaeie?eiieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i.

I.I.Aiaiiieueoey, IIC Oe?a?ie

IAOEIAEE EA??AIEE:

aeieoi? iaaee/ieo iaoe, i?ioani? Aiaeia? Iao?i

Ieeieaeiae/, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.

I.I.Aiaiiieueoey, caa?aeoaa/ eaoaae?e aiaeie?eiieia??

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani? Ieeoea Oa?an Aeaieniae/,

Iaoe?i iaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey,

caa?aeoaa/ eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia N 2

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee

Eo/eoeueeee ?aaai Aaneeueiae/, ?inoeooo aiaeie?eiieia?? oa

iai?io ?a/iaei ?i. A.I.Eii?na?aiea AII Oe?a?ie, caa?aeoaa/

a?aeae?eii ee?i?/ii? aiae?ieia??

I?IA?AeIA ONOAIIAA: ?aaii-O?aie?anueea aea?aeaaia

iaaee/ia aeaaea i?y, eaoaae?a aiaeie?eiieia??, IIC Oe?a?ie, i.

?aaii-O?aie?anuee

Caoeno a?aeaoaeaoueny “17” eenoiiaaea 1998 ?. i 13.00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.558.01 c aiaeie?eiieia??
a ?inoeooo? aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I.Eii?na?aiea AII
Oe?a?ie (254114, Ee?a-114, aoe. Aeoai?iaenueea, 69).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I.Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe.. Aeoai?iaenueea, 69).

Aaoi?aoa?ao ?ic?neaiee “15” aeiaoiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Eaeeinueea E.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oeoe?iaee ae?aaao (OeAe) ? iaeiei c iaea?eueo
?iciianthaeaeaieo caoai?thaaiue. E?euee?noue oai?eo ia ae?aaao neeaaea?
aeecueei 4% ? a inoaii?e /an o anueiio na?o? i?ia?aneaii ca?eueoo?oueny
[AIIC, 1994]. I?iaeaia OeAe ? iaaecae/aeii aeooaeueiith aeey Oe?a?ie,
ine?eueee ia ii/aoie 1996 ?ieo e?euee?noue oai?eo ia ae?aaao neeaaeaea
a?ey 900 oen. in?a [I.Ae.O?iiueei c? ni?aaao., 1996]. Ai?aeai?ieia?/ieie
aeine?aeaeaiiyie anoaiiaeaii, ui nia?oi?noue oai?eo ia OeAe, a 3 ?ace
ia?aaeuo? a?aeiia?aeio a caaaeuei?e iiioeyoe?? [A.N.Aoeiia e niaao.,
1983, 1989, 1994; I.E.Aaeaaieeei, 1994].

Aieea aeieia?/ieo ci?i iaaeieeoiueiai na?aaeiaeua ia ethaeeio ? iaei??th
c aeooaeueieo oai no/anii? iaaeeoeeie. Iioe?aiee ?ioa?an aei oeueiai a
inoaii?e /an aeeeeeaiee iane?aeeaie aaa??? ia *AAN. Aea/aiiyi aieeeo
“*i?iiaeeuenueeiai /eiieea” (**) ia i?aai?ci ethaeeie aeoeaii
caeiathoueny o anueiio na?o? [A.I.Aioiiia, 1989; C.K.Cassel et al.,
1989; Ph. Hubert et al., 1989]. Iaeaea 45,6% an?o iino?aaeaeaeeo a?ae
*i?iiaeeuenueei? eaoano?ioe i?iaeeaa? ia Oe?a?i? [TH.I.Ni?aeaiei c?
ni?aaao., 1993; AIIC, 1995; A.I.Na?aaethe, 1997].

Noai caei?ia`y in?a, ui caciaee aieeao iane?aee?a *i?iiaeeuenueei?
eaoano?ioe cia/ii iia??oeany [I.?.Aa?aiaiei, 1993, 1995; A.E.Aonueeiaa,
1993; J.Conredy, 1989]. Iai?oeeany no?eea oaiaeaioe?y c?inoaiiy na?aae
ieo caaaeueii? caoai?thaaiino? [A.A.?iiaiaiei, 1992; M.M.Quinn et al.,
1987; H.David Wegman, 1987], a?eueo aaaeeei noaa ia?aa?a aaaaoueio
caoai?thaaiue [A.O.Aic?aiia, 1996]. Ca inoaii? a?n?i ?ie?a e?euee?noue
caei?iaeo in?a na?aae o/aniee?a e?ea?aeaoe?? iane?aee?a *i?iiaeeuenueei?
eaoano?ioe ciaioeeanue o 4 ?ace [A.O.Aic?aiia, 1996].

Aeiaaaeaia ao?ieia?/ia ?ieue ?ii?coth/iai aei?ii?iaiiy a iaoieia??
ueoiaeaeii? caeice [A.Ae.*a?iia?ia c? ni?aaao., 1994; A.?.Aioeth?ei,
1995; O.?.Aiaaeaiiaa, 1996], ii?ooaii? noaoaai? noa?e [I.I.Aeai/aiei,
1994], o?aaeaii? a?iioaeaii-a?iio?ca?ii-iaaeie?ieeiai? nenoaie
[I.I.Eiaaeaiei, 1992, 1994, 1996; I.N.?ii-Aoaineaanueea c? ni?aaao.,
1994; O.I.Aacaa?oa c? ni?aaao., 1996]. Ieoaiiyi i?ney/i?iiaeeuenueeiai
ooeiaeaeaiiy aiaeie?eiiiai aia?aoo i?aeoeoieiai? caeice i?eae?ey?oueny
iaaeinoaoiy oaaaa, ui iaaii iia`ycaii c eiioeaioe??th
?aae?i?acenoaioiino? inoaiiuei? [I.Ae.O?iiueei e niaao., 1991]. Iaeia/a,
caoai?thaai?noue ia OeAe na?aae iaoeaioe?a caa?oaeiaieo
?aae?iioee?aeaie oa?eoi??e oa o/aniee?a e?ea?aeaoe?? iane?aee?a
*i?iiaeeuenueei? eaoano?ioe c?inoa? [A.E.E?aa/aiei e niaao., 1991;
A.I.Iaai?ia c? ni?aaao., 1994; TH.I.Ni?aeaiei, 1994; A.E.*aaai, 1994,
1996; A.E.Okeanov et al., 1996].

*a?ac oea ie ae??oeee aea/eoe iniaeeaino? ee?i?/iiai ia?aa?ao OeAe a
o/aniee?a e?ea?aeaoe?? iane?aee?a aaa??? ia *i?iiaeeuenuee?e AAN (OEIA)
? canoinoaaoe a e?eoaaii? oe??? eaoaai??? oai?eo iia? aoaeoeai? caniae
e?eoaaiiy – eaca?iioieoo?o oa aioa?ini?aoe?th, caaaeyee ?o iiceoeaiiio
aieeao ia ?ioiio nenoaio ? iai?i ?a/iaei [A.I.Ieoaeue/eoei, 1995, 1996;
?.?.Aaeaea, 1996; K.Lam et al., 1995].

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. ieaiaie, oaiaie. Aeine?aeaeaiiy
aeeiiaii ca?aeii ieaio iaoeiai-aeine?aeieoeueei? ?iaioe Aieiaiiai
a?enueeiai-iaaee/iiai oi?aae?iiy II Oe?a?ie oa Oe?a?inueei?
a?enueeiai-iaaee/ii? aeaaeai??.

Iaoa ?iaioe. Ioe?iea aoaeoeaiino? eiiieaenii? oa?ai?? OEIA, oai?eo ia
?inoe?iicaeaaeiee oeoe?iaee ae?aaao (?COeAe) oa ?inoe?iiiacaeaaeiee
oeoe?iaee ae?aaao (?IOeAe), c canoinoaaiiyi aioa?ini?aoe?? ?
eaca?iioieoo?e.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe iniaeeaino? ee?i?/iiai ia?aa?ao ?COeAe oa ?IOeAe o o/aniee?a
e?ea?aeaoe?? iane?aee?a *i?iiaeeuenueei? eaoano?ioe.

2. I?iaanoe ii??aiyeueiee aiae?c ci?i iieaciee?a aoaeaaiaeiiai ?
e?i?aeiiai iai?i?a, noaio ia?aeeniiai ieeneaiiy e?i?ae?a (IIE),
no?oeoo?ii-ooieoe?iiaeueieo ii?ooaiue e?aiai oeoii/ea o oai?eo c ??cieie
oeiaie OeAe a caeaaeiino? a?ae iayaiino? *i?iiaeeuenueeiai /eiieea a
aiaiiac?.

3. Ioe?ieoe aieea o?aaeeoe?eii? i?ioeae?aaaoe/ii? oa?ai??, eiiieaenii?
oa?ai?? c aioa?ini?aoe??th ni?aaioii “Aoaeani?a” oa eaca?iith
aeoioieoo?ith ia ee?i?/i? iieacieee o OEIA, oai?eo ia ?COeAe oa ?IOeAe.

4. I?iaanoe ioe?ieo aoaeoeaiino? e?eoaaiiy oai?eo ia OeAe-OEIA c
canoinoaaiiyi aioa?ini?aoe?? ? eaca?iioieoo?e ia i?aenoaa? eiiieaenii?
ioe?iee ci?i iieaciee?a aoaeaaiaeiiai ? e?i?aeiiai iai?i?a, IIE,
no?oeoo?ii-ooieoe?iiaeueiiai noaio e?aiai oeoii/ea.

Iaoeiaa iiaecia ?iaioe. Aia?oa aea/ai? iniaeeaino? ee?i?/iiai ia?aa?ao
OeAe o OEIA. Iieacaii, oi aeey oai?eo ia ?COeAe-OEIA, a ii??aiyii? c
eiio?ieueiith a?oiiith, a?eueo oa?aeoa?ia eaa?euei?noue
ia?aa?aocaoai?thaaiiy c? noeeuei?noth aei a?iiae?eai?e, oa?aeoa?iee
/ano?oee ?icaeoie iae?iaia?iiao?e, iae?iiao?e, a?oa??aeueii?
a?ia?oaic??. A o oai?eo ia ?IOeAe-OEIA aei oeueiai i?e?aeio?oueny a?eueo
eaa?eueiee ia?aa?a oai?iae c? noeeuei?noth aei eaoiaoeeaeico, /ano?oee
?icaeoie aeaeiiiainaoe??, aoi?eiii? noeueoai?eai?aeii? ?acenoaioiino? oa
i?e?iaia?iiao??.

Aia?oa aeyaeai? iniaeeaino? aoaeaaiaeiiai, e?i?aeiiai iai?i?a oa
aeoeaiino? IIE o oai?eo ia OeAe-OEIA. Oae o oai?eo ia ?COeAe
a?aei?/aeenue cia/i?o? ii?ooaiiy, a ii??aiyii? c eiio?ieueiith a?oiith
oai?eo, aoaeaaiaeiiai iai?io oa IIE. A o oai?eo ia ?IOeAe – cia/i?o?
ii?ooaiiy aoaeaaiaeiiai ? e?i?aeiiai iai?i?a.

Aia?oa i?iaaaeaii aea/aiiy no?oeoo?ii-ooieoe?iiaeueieo ci?i e?aiai
oeoii/ea na?oey o OEIA, oai?eo ia OeAe. Iieacaii, ui o oeeo oai?eo
a?aei?/aeenue a?eueo cia/i?, i?ae a eiio?ieuei?e a?oi?, ii?ooaiiy
nei?ioeeai? caeaoiino? e?aiai oeoii/ea, ye? cia/i?o? o oai?eo ia ?IOeAe.

Aia?oa aea/aia aoaeoeai?noue eiiieaenii? oa?ai?? c aioa?ini?aoe??th
ni?aaioii “Aoaeani?a” ? eaca?iioieoo?ith o oai?eo ia OeAe-OEIA.
Aeieacaia ?o aoaeoeai?noue, yea coiiaeaia ii?iae?coth/ei aieeaii ia
aoaeaaiaeiee, e?i?aeiee iai?ie oa no?oeoo?ii-ooieoe?iiaeueiee noai
e?aiai oeoii/ea, a o eaca?iioieoo?e – ua e ae?aaeaiith aioeieneaeaioiith
ae??th.

Aia?oa i?iaaaeaii ei?aeyoe?eiee aiae?c i?ae iieacieeaie iai?io ?a/iaei
oa no?oeoo?ii-ooieoe?iiaeueiiai noaio e?aiai oeoii/ea o oai?eo ia
OeAe-OEIA. Aeiaaaeaia iayai?noue aca?iica’yce?a i?ae iieacieeaie
nenoiee/ii? ooieoe?? e?aiai oeoii/ea ? iieacieeaie aoaeaaiaeiiai iai?io
oa IIE o oai?eo ia ?COeAe. A o oai?eo ia ?IOeAe-OEIA – i?ae iieacieeaie
no?oeoo?ii-ooieoe?iiaeueiiai noaio e?aiai oeoii/ea ? iieacieeaie
aoaeaaiaeiiai oa e?i?aeiiai iai?i?a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeyaeaii iniaeeaino?
ee?i?/iiai ia?aa?ao OeAe o OEIA. Anoaiiaeaii, ui 10-aeaiiee eo?n
eaca?iioieoo?e ? aioa?ini?aoe?? ni?ey? eiiiainaoe?? OeAe, onoaa? /e
ciaioo? eiai ee?i?/i? i?iyae oa oneeaaeiaiiy, iiceoeaii aieeaa? ia
aoaeaaiaeiee, e?i?aeiee iai?ie, aeoeai?noue IIE oa
no?oeoo?ii-ooieoe?iiaeueiee noai na?oey. ?acoeueoaoe aea/aiiy
iniaeeainoae ee?i?/iiai ia?aa?ao oa e?eoaaiiy oeoe?iaiai ae?aaaoo a
o/aniee?a e?ea?aeaoe?? iane?aee?a *i?iiaeeuenueei? eaoano?ioe
aeei?enoiaothoueny o aeeeaaeaii? ia eaoaae?? a?enueeiai? oa?ai??
Oe?a?inueei? a?enueeiai-iaaee/ii? aeaaeai??, eaoaae?? aiaeie?eiieia??
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo. Io?eiai? aeai? aeicaieythoue
?aeiiaiaeoaaoe aioa?ini?aoe?th oa eaca?iioieoo?o o e?eoaaeueio i?aeoeeo
aei oe?ieiai aeei?enoaiiy a eiiieaeni?e oa?ai?? oai?eo ia ae?aaao. Oe?
iaoiaee e?eoaaiiy iiaeooue aeei?enoiaoaaoenue a e?eoaaeueieo caeeaaeao
IIC oa II Oe?a?ie.

Iniaenoee aianie aaoi?a. A?i naiino?eii aeeiiaa on? ee?i?/i? oa
eaai?aoi?ii-?ino?oiaioaeuei? aeine?aeaeaiiy, i?ia?a aiae?c, ioi?iea
iaoa??aee aeena?oaoe?? noi?nii c iaoeiaei ea??aieeii. Aaoi?o
iaeaaeeoue aieiaia ?ieue o i?aeaioiaoe? io?eiaieo aeaieo aei an?o
iaoeiaeo ioae?eaoe?e.

Ai?iaaoe?y ?iaioe. ?acoeueoaoe ?iaioe aeiiia?aeaeenue ia Ee?anuee?e
i?nueeee iaoeiai-i?aeoe/i?e eiioa?aioe?? e?ea??a-aiaeie?eiieia?a (1996
??e), can?aeaiiyo eaoaae?e aiaeie?eiieia?? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ? eaoaae?e a?enueeiai? oa?ai?? Oe?a?inueei?
a?enueeiai-iaaee/ii? aeaaeai?? (Ee?a, 1996, 1997), YI Eiia?an? Na?oiai?
Oaaea?aoe?? Oe?a?inueeeo e?ea?nueeeo oiaa?enoa (Iaeana, 1996),
eiioa?aioe?? iieiaeeo o/aieo Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo
(Ee?a, 1997), can?aeaii? Ee?anueeiai i?nueeiai oiaa?enoaa oa?aiaao?a
(1998 ??e).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii /ioe?e iaoeia?
i?aoe?, c yeeo o?e noaoo? a iaoeiaeo oaoiaeo aeo?iaeao, ui caoaa?aeaeai?
AAE Oe?a?ie, oa iaei? oace.

Ia’?i ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 176 noi??ieao
iaoeiiieniiai oaenoo ? neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, 4
?icae?e?a aeanieo aeine?aeaeaiue, iaaiai?aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, iieaae/eea e?oa?aoo?e. Oaeno aeena?oaoe?? ?ethno?iaaii 3
iaethieaie, 22 oaaeeoeyie, 1 noaiith. A?ae?ia?ao?/iee iieaae/ee aeeth/a?
349 e?oa?aoo?ieo aeaea?ae.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Ianoaaeaii 103 OEIA, ye? i?eeiaee
o/anoue o e?ea?aeaoe?? iane?aee?a *i?iiaeeuenueei? eaoano?ioe a ia??iae
aei eeiiy 1986 ?ieo, ? i?ney oeueiai caoai??ee ia OeAe. Na?aae ieo aoei
28 oai?eo ia ?COeAe ? 75 oai?eo ia ?IOeAe. Eiio?ieueio a?oio neeaee 64
iniae, ye? ia i?eeiaee o/ano? o e?ea?aeaoe?? iane?aee?a aaa??? ia *AAN,
ia i?iaeeaaee ia caa?oaeiaieo ?aae?iioee?aeaie oa?eoi??yo ? caoai??ee ia
OeAe i?ney eeiiy 1986 ?ieo. Na?aae ieo aoei 33 oai?eo ia ?COeAe ? 31
oai?ee ia ?IOeAe. An? ianoaaeai? aoee /ieia?/i? noao?. Ca a?eii,
o?eaae?noth oa aaaee?noth ia?aa?ao ?COeAe oa ?IOeAe a?oie, ui
ii??aithaaeenue, aoee noaoenoe/ii iaeii??aei? (?>0,05).

A iiaeaeueoiio oai?? ia OeAe-OEIA aoee ?iciiae?eai? ia o?e a?oie, ye?
ca a?eii, o?eaae?noth oa aaaee?noth ia?aa?ao caoai?thaaiiy aoee oaeiae
noaoenoe/ii iaeii??aei? (?>0,05). Ia?oa a?oia oai?eo (n=31) e?eoaaeanue
o?aaeeoe?eiith i?ioeae?aaaoe/iith oa?ai??th (7 oai?eo ia ?COeAe oa 24
oai?eo ia ?IOeAe). Oai?? ae?oai? a?oie (n=38) ii?o/ c o?aaeeoe?eiith
oeoe?icieaeoth/ith oa?ai??th io?eioaaee aioa?ini?aaio “Aoaeani?a”,
na?aae ieo oai?eo ia ?COeAe aoei 10 in?a, oai?eo ia ?IOeAe – 28 /ieia?e.
O?aoy a?oia (n=34) aeiaeaoeiai aei o?aaeeoe?eii? oa?ai?? e?eoaaeanue
eaca?iioieoo?ith (11 oai?eo ia ?COeAe oa 23 oai?? ia ?IOeAe).
O?aaeeoe?eia oa?ai?y OeAe aeeth/aea oeoe?icieaeoth/? (?inoe?i aai
ia?i?aeuei? i?aia?aoe – iio?aei? noeueoai?ena/iaeie), aia?ii?ioaeoi?i?
(i?aia?aoe i?eioeiiai? eeneioe) oa aaiaoii?ioaeoi?i? (ea?n?e,
anaioe?ae?) caniae, a?oai?ii? i?aia?aoe (A1, A6, A12 /a?ac aeaiue).

Ae?oaa a?oia oai?eo ia OeAe-OEIA e?eoaaeanue ii?o/ c o?aaeeoe?eiith
oeoe?icieaeoth/ith oa?ai??th aioa?ini?aaioii “Aoaeani?a”. I?aia?ao
i?ecia/aee a ia?a?aao i?ae i?eeiiaie ?aee oa ?ioeo e?e?a (1,5-2 aiaeeie
aei ? i?ney ?aee) ii 0,5 o?e/? ia aeaiue. ?aeiiaiaeoaaee caieaaoe
??aeeiith. Eo?n e?eoaaiiy 10 aei?a.

O?aoy a?oia oai?eo ia OeAe-OEIA aeiaeaoeiai aei o?aaeeoe?eii?
oeoe?icieaeoth/i? oa?ai?? e?eoaaeanue eaca?iioieoo?ith. A oeueiio
aeine?aeaeaii? ie aeei?enoiaoaaee aae?e-iaiiiaee eaca? /a?aiiiai niaeo?o
c aeiaaeeiith oaee? 632,8 ii. I?iaiaeeee ii?ii?iaiiy oi/ie eeane/ii?
aeoioieoo?e (eaca?iioieoo?a). Ii?ii?iaiiy i?iaiaeeeinue ca aeiiiiiaith
eaca?ii? onoaiiaee EA-75-1. Aeey eaca?iioieoo?e aeei?enoiaoaaee oi/ee
A36, RP6, G14, o oai?eo c ae?aaaoe/ieie aia?i- oa iae?iiao?yie a noaio
e?eoaaiiy aoee aeeth/ai? ua /ioe?e aeoeai? oi/ee: F2, F3 (/a?ac aeaiue),
V40, V57. Naaine i?iaiaeeee eiaeiee aeaiue, aieea ia iaeio oi/eo o?eaaa
30 naeoiae, any i?ioeaaeo?a o?eaaea ia a?eueoa 6 oaeeei. Eo?n
eaca?iioieoo?e aeeth/aa 10 naain?a. U?euei?noue iiooaeiino? eaca?iiai
aei?ii?iaiiy noaiiaeea 1,5 iAo/ni2. Aeuacacia/ai? aeoioieoo?i? oi/ee
aecia/aee iaoiaeii i?iii?oe?eiiai oeoiy.

Ianoaaeoaaee oai?eo aei oa i?ney e?eoaaiiy – i?e aini?oae?caoe?? oa
i?ney caaa?oaiiy eo?no aioa?ini?aoe?? /e eaca?iioieoo?e.

Aeey ioe?iee iniaeeainoae ia?aa?ao OeAe o OEIA oa aoaeoeaiino? e?eoaaiiy
a?aoiaoaaee aeeiai?eo ee?i?/ieo neiioii?a, nooiaiy ae?eai??, caaaeueiiai
a?eea, caaaeueiiai oieanoa?eio (ON) ieacie oa ON e?iii?ioa?i?a aeniei?
aonoeie (EIAA), e?aao?i?io, na/iaeie, a?e??oa?io, aeoeaiino?
o?ainai?iac, ??ai?a ae?eiceeueiaaiiai aaiiaeia?io (IaA1n), o?oeoicai?io
(OA), iaeiiiaiai ae?aeueaeaa?aeo ieacie ? a?eo?ioeeo?a (IAeAI oa IAeAA).
Ioe?ithaaee oaeiae ?aia?ao?/i? iieacieee, ui oa?aeoa?ecothoue noai
noaeei ieaei?o e?ioe?aie, nei?i/oaaeueio caeaoi?noue i?iea?aea – ca
aeaieie aoiea?ae?ia?ao??.

Caaaeueiee ON ieacie, ON EIAA, IAeAI oa IAeAA aecia/aee ai?iaiaaieie
iaoiaeaie [E.Oiaei?ia, 1963; I.N.Aii/a?aiei e niaao., 1985]; OA ieacie
– ca eaei?eiao?e/iei iaoiaeii c aeei?enoaiiyi i?o?ineiueiai oao?acie?th
[L.Cruschelli, 1990]; ??aaiue IaA1n – oaeiae ca eaei?eiao?e/iei iaoiaeii
[E.V.Subramanian et al., 1980].

Ae?aaiic OeAe anoaiiaethaaany ia i?aenoaa? oa?aeoa?ieo nea?a, aiaiiaco
caoai?thaaiiy e aeeooy, aeaieo o?c?eaeueiiai ianoaaeaiiy, ??ai?a
ae?eai??, IaA1n, aetheico???, eaoiio???.

Aaaee?noue ia?aa?ao OeAe ioe?ithaaee caaaeueiii?eeiyoeie e?eoa??yie
[A.N.Aoeiia e niaao., 1983, 1989; I.E.Aaeaaieeei, 1994; I.O.Noa?eiaa e
niaao., 1997]. E??i oiai, a?aoiaoaaee iniaeeaino? ia?aa?ao ae?aaaoo
(eaa?eueiee, noaa?eueiee), iayai?noue oneeaaeiaiue.

Nooiaiue eiiiainaoe?? OeAe ioe?ithaaee ca aeiiiiiaith ee?i?/ieo ?
eaai?aoi?ieo aeaieo. sseui ca aeaieie ae?eai?/iiai i?io?eth eieeaaiiy
ae?eai?? ia ia?aaeuoaaei 7,0 iiieue/e, a na/? aaetheico??y, HbA1c ia
aeua 7%, oi noai ae?aaaoo ioe?ithaaee ye eiiiainiaaiee. Eieeaaiiy
ae?eai?? aei 11 iiieue/e ?icoe?ithaaee ye noaeiiiainiaaia, a aeua 11
iiieue/e – ye aeaeiiiainiaaia.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Io?eiai? iaie aeai?
na?ae/aoue i?i iayai?noue iaaieo iniaeeainoae ee?i?/iiai ia?aa?ao OeAe o
OEIA. O OEIA, oai?eo ia ?COeAe /ano?oa, i?ae o oai?eo eiio?ieueii?
a?oie, a?aei?/aeanue eaa?euei?noue ia?aa?ao caoai?thaaiiy c?
noeeuei?noth aei a?iiae?eai?e (o 1,8 ?ace, ?0,05).

O oai?eo ia ?COeAe oa ?IOeAe – OEIA /ano?oa, i?ae o oai?eo eiio?ieueii?
a?oie, a?aei?/aeenue: ae?aaaoe/ia iae?iaia?iiao?y ieaei?o e?ioe?aie
(a?aeiia?aeii o 2,6 oa 1,7 ?ace, ?0,05 o an?o aeiaaeeao). O oai?eo ia ?COeAe-OEIA eiiieaenia
i?ioeae?aaaoe/ia oa?ai?y c aioa?ini?aaioii “Aoaeani?a” cieaeoaaea ??ai?
ae?eai?? iaoua oa i?ney oa?/iaiai iaaaioaaeaiiy (o 1,4 ?ace, ?0,05). Eiiieaenia i?ioeae?aaaoe/ia
oa?ai?y c aioa?ini?aoe??th ni?aaioii “Aoaeani?a” o oeeo oai?eo
cieaeoaaea aoa?iaaii? aeanoeaino? ieacie o 3,5 ?ace (P0,05). Eiiieaenia oa?ai?y c ni?aaioii
“Aoaeani?a” o oeeo oai?eo cieaeoaaea ?iaeaen aoa?iaaiiino? (?A) o 1,9
?ace (P0,05

4,97+0,28

>0,05

66,69+1,05

>0,05

134,07+2,11

>0,05

81,99+1,11

0,05

61,12+1,03

0,05

58,79+0,99

0,05

5,49+0,15

>0,05

79,22+2,03

0,05

72,99+0,72

0,05

5,30+0,14

0,05

5,15+0,15

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