13

I?I?NOA?NOAI IOI?IIE CAeI?IA`ss OE?A?IE

EE?ANUeEEE iaoeiai-aeine?aeiee ?inoeooo ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea

Oeiaa ss?ineaa Aaneeueiae/

OAeE 616.216.1-002-08

Iniaeeaino? ee?i?/iiai ia?aa?ao oa eiiieaenia e?eoaaiiy o?ii?/iiai
caiaeaiiy aa?oiueiuaeaiieo iacoo o oai?eo aei oa i?ney aaa??? ia
*i?iiaeeuenuee?e aoiii?e aeaeo?inoaioe??.

14.01.19.-ioi?eiiea?eiaieia?y

aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a-1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe
?i. I.E. Ooieea, IIC Oe?a?ie (i.Ee?a).

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?, caa?aeoaa/ eaoaae?e
ioi?eiiea?eiaieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieii ii?
ina?oe ?i. I.E.Ooieea Aiaaeai A?eai?iae/ ?nuee?a.

Io?oe?ei? iiiiaioe: Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani?, caa?aeoaa/ eaoaae?e ioi?eiiea?eiaieia??
Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai?? Na?a?e Ai?eniae/
Aacoaii/iee.

Aeieoi? iaaee/ieo iaoe, i?ioani?, caa?aeoaa/ eaoaae?e ioi?eiiea?eiai
eia?? Eoaainueeiai iaaee/iiai oi?aa?neoaoo Aaeaioei ?iiaiiae/ Aeaiaieia.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?iai? I.I.
Aiaiiieueoey, IIC Oe?a?ie, eaoaae?a ioi?eiiea?eiaieia??, i. Ee?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny «20» aeiaoiy 1999 ?ieo i 12 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.611.01 a
Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo? ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea (i.Ee?a, aoe Ciieia?/ia, 3).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo.

Aaoi?aoa?ao ?ic?neaii «14» aa?aniy 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe A.?.
?iceeaaeea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

O?ii?/i? neio?oe ? iioe?aiith iaoieia??th o no?oeoo??
aini?oae?ciaaii? caoai?thaaiino?. Ca aeaieie aeayeeo aaoi??a aei 5%
ianaeaiiy oai??? oe??th iaoieia??th (Eociaoeia A.N.e niaao.,1982;
Oa?ania Ae.E., 1991). A NOA 14% ianaeaiiy oai??? neioneoii (Kaliner
Michael A., et al. 1997).

A aeine?aeaeaiiyo, iniaeeai, ui noino?oueny oai?eo, ye? iino?aaeaeaee
a?ae iane?aee?a aaa??? ia *AAN, i?aee?aneth?oueny, ui a ieo
niinoa??aa?oueny ?yae ?ioeo caoai?thaaiue, ye? a ii?aeiaii? c o?ii?/iei
caiaeaiiyi aa?oiueiuaeai ieo iacoo ua a?eueoa iia??oothoue noai
oai?iai (Aieeia I.?. ? ni?aaaoi?e, 1992, Aieiai?iaeueei I.I. ?
ni?aaaoi?e, 1993). Oiio e?eoaaiiy iino?aaeaeaeeo a i?neyaaa??eiee
ia??iae, c ??ciith iaoieia??th o ii?aeiaii? c caiaeaiiyi i?eiiniaeo
iacoo, aeiaaa? eiiieaeniiai i?aeoiaeo c a?aooaaiiyi noaio ?ioi?oaoo
(Caaieioiue Ae.E., 1989, Iiaa?ia TH.A. 1994, O?iai A.Y. ? ni?aaa.,
1998). Oea coiiaeth? iio?aao iiaeeaeaiiai aea/aiiy /anoioe ??cieo oi?i
caoai?thaaiiy, iniaeeainoae ia?aa?ao, cie?aia oneeaaeiaieo i?a?oaeueiith
oa aioo??oiuei/a?aiiith iaoieia??th (Aioiai A.?., ? ni?aaa., 1995,
Ieoiue I.N., 1997, ?iceeaaeea ?.A., 1997, ssuaiei I.?., 1998, Moloney
J.R., et al., 1987).

Eiina?aaoeaia e?eoaaii? oai?eo c aino?eie oa o?ii?/ieie caiaeueieie
i?ioeanaie i?eiiniaeo iacoo aeicaiey? aeinyaiooe iaaiiai oni?oo
(Aacoaii/iee N.A. e niaao. 1987, Aeaaeoo TH.E., 1989, 1995, Duncavage
J.A., et al., 1986, 1988, Antila I.,et al., 1989, Malow J.B.,et
al.,1989). Iaeiae iaiao?aei? iiooee iiaeo iaoiae?a e?eoaaiiy, ye?
aeathoue iiaeeea?noue aieeaaoe ia caaaeueio ?aaeoeai?noue i?aai?cio, c
iaoith iiia?aaeaeaiiy ?aoeeaeea?a, aeinyaiaiiy noaa?eueii? ?ai?n??.
Ine?eueee aa?’??ia ooieoe?y neeciaeo iaieiiie aa?oi?o aeeoaeueieo
oeyo?a iia’ycaia c ?ioiieia?/ieie iaoai?ciaie, ?o aea/aiiy noaei iaeiei
c i?ia?aeieo iai?yie?a no/anii? ?eiieia?? (Caaieioiue Ae.E. 1989, Sethi
D.S.,et al.,1995, Lund V. J. 1996).

A ca’yceo c aeuaneacaiei, aoei i?iaaaeaii aea/aiiy iniaeeain oae
ia?aa?ao o?ii?/ieo caiaeueieo i?ioean?a i?eiiniaeo iacoo aei, oa i?ney
aaa??? ia *i?iiaeeuenuee?e aoiii?e aeaeo?inoaioe??, iaa?oiooaaiiy
eiiieaeniiai eiina?aaoeaiiai e?eoaaiiy c aeei?enoaiiyi ae?aioaaiiy iacoo
c ianooiiei aaaaeaiiyi iaaeeeaiaio?a, ? aeei?enoaiiyi o?ce/ieo oaeoi??a,
cie?aia iaeiiiiiaioiiai oiiioi?aco e?ea?nueeeo cania?a a ii?iaeieio
iacoo oa iina, a oaeiae canoinoaaiiy e?i?eii-iiey?eciaaiiai
iaeiaa?aioiiai na?oea c aeiaaeeiith oaee? 400-2000 ii. aeey i?aeaeuaiiy
caaaeueii? ?acenoaioiino? i?aai?cio.

Ca’ycie c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?y aeeiiaia ca ieaiii iaoeiai-aeine?aeieo ?ia?o eaoaae?e
ioi?eiiea?eiaieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe ?i. I.E. Ooieea ia oaio: «?ic?iaea iiaeo oa aaeineiiaeaiiy
?nioth/eo iaoiae?a e?eoaaiiy oai?eo ia na?aaei?e ioeo ? aeaye? o?ii?/i?
caoai?thaaiiy aa?oi?o aeeoaeueieo oeyo?a. ? aea?aeaaii? ?a?no?aoe??
0196I010579.

Iaoa ?iaioe

Aeyaeaiiy iniaeeainoae ia?aa?ao o?ii?/ieo aa?oiueiuaeaiieo neioneo?a a
aei oa a i?neyaaa??eiee ia??iaee oa i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy
oai?eo ia o?ii?/i? aa?oiueiuaeaii? neioneoe.

caaaeaiiy aeine?aeaeaiiy.

1. Aeyaeaiiy ee?i?/ieo iniaeeainoae ia?aa?ao caoai?thaaiino? ia o?ii?/ia
caiaeaiiy aa?oiueiuaeaiieo iacoo o ia??iae aei oa i?ney aaa??? ia *AAN.

2. I?iaaaeaiiy aeine?aeaeaiiy noaio caaaeueii? ?ioiieia?/ii?
?aaeoeaiino? o iaoe??io?a c o?ii?/iei aa?oiueiuaeaiiei neio neoii aei oa
i?ney aaa??? ia *AAN.

3. Ioe?ieoe iiaeeeaino? I?O a ae?aaiinoeoe? o?ii?/ieo
aa?oiueiuaeaiieo neioneo?a.

4. Ioe?ieoe cia/aiiy ae?aiaaeiiai iaoiaeo a eiiieaen? caoiae?a i?e
e?eoaaii? ??cieo oi?i o?ii?/iiai aa?oiueiuaeaiiiai neioneoo.

5. Aea/eoe aoaeoeai?noue aeayeeo iiaeo iaoiaeee canoinoaaiiy o?ce/ieo
oaeoi??a a eiiieaeniiio e?eoaaii? o?ii?/ieo aa?oiueiuaeaiieo
neioneo?a.

6. Ioe?ieoe aieea ae?? e?i?eii iiey?eciaaiiai iaeiaa?aioiiai na?oea ia
aoaeoeai?noue e?eoaaiiy o?ii?/ieo aa?oiueiuaeaiieo neioneo?a.

Iaoeiaa iiaecia

1. Anoaiiaeaia /anoioa o?ii?/iiai aa?oiueiuaeaiiiai neioneoo ca
iaoai?ciii aeieeiaiiy: ?eiiaaiiee-55% a 81-85 oa 58% 91-95??,
iaeiioiaaiiee-22% a 1981-1985??. oa 23% o 1991-1995??. ci?oaiee–23% a
1981-1985??. oa 19% o 1991-1995??.; ca ee?i?/iei ia?aa?aii: eaaea
oi?ia-o 39,6% a 1981-1985??. oa 35,2% o 1991-1995 ??., na?aaeiuei?
aaaeeino?-59,5% a 1981-1985??., oa 60,9% o 1991-1995??., oyaee?
oneeaaeiaiiy-0,91% a1981-1985??., oa 3,19% o 1991-1995 ?ieao.

2. I?eaaaeaia oa?aeoa?enoeea noaio O- ? A-nenoai ?ioi?oaoo o oai?eo ia
o?ii?/iee aa?oiueiuaeaiiee neioneo aei oa i?ney aaa??? ia /aan.

3. Aea/aia aoaeoeai?noue eiiieaeniiai iaoiaeo e?eoaaiiy, iniiaiei
eiiiiiaioii yeiai ? ae?aioaaiiy aa?oiueiuaeaiieo iacoo ? canoino aaiiy
ao?io?iiieo oa iaoiaaiaoe/ieo cania?a iaoiaeii 2-3 ?aciaiai c?ioaiiy,
aaaaeaiiy ?o oeyoii oiiioi?aco, canoinoaaiiy e?i?eii iiey?eciaaiiai
iaeiaa?aioiiai na?oea.

4. I?iaiae?ciaaii aieea e?i?eii-iiey?eciaaiiai iaeiaa?aioiiai na?oea ia
aoaeoeai?noue e?eoaaiiy aeayeeo oi?i o?ii?/ieo aa?oiueiuaeaiieo
neioneo?a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

Eiie?aoecaoe?y /anoioe caoai?thaaiino? ia o?ii?/i? aa?oiueiuaeai i?
neioneoe ca ee?i?/ieie, iaoaiaoii?/ieie iciaeaie aeicaiey? i?iaiaeeoe
aeeoa?aioe?eiaaia ? eiiieaenia e?eoaaiiy, i?aeaeueoe eiai aoaeoeai?noue.

Ia aaeeeiio ee?i?/iiio iaoa??ae? aeiaaaeaia aeioe?euei?noue ae?aioaaiiy
aa?oiueiuaeaiieo iacoo i?e e?eoaaii? aenoaeaoeaieo oa ci?oa ieo oi?i
aa?oiueiuaeaiieo neioneo?a.

Canoinoaaiiy aeinooiieo iaoiaeee oiiioi?aco ei?oeeinoa?i?aeie ie
i?aia?aoaie ni?ey? a?aeiiaeaiith aeeoaeueii? ooieoe?? iina, ?icoe?aiith
aea?aeieo ioai??a aa?oiueiuaeaiieo iacoo, e?ea?aeo? iaa?ye, iie?iici?
ci?ie neeciaeo iaieiiie iina oa neion?a.

Ae?aioaaiiy, aeei?enoaiiy ii?aeiaii? iaoiaeeee aaaaeaiiy e?e?a a iacooo
? ii?iaeieio iina i?e oiiioi?ac? oa canoinoaaiiy e?i?eii-iiey?eciaaiiai
na?oea eaiie «A?iio?ii-2», aea? ciiao ia 2-3 aei? nei?ioeoe ia??iae oa
aeinyaoe e?aui? aoaeoeaiino? e?eoaaiiy aenoaeaoeaieo oi?i o?ii?/iiai
neioneoo.

ai?iaaaeaeaiiy a i?aeoeeo

Cai?iiiiiaaia iaoiaeeea ae?aaiinoeee oa eiiieaenia e?eoaaiiy caiaeueieo
i?ioean?a i?eiiniaeo iacoo iina c canoinoaaiiyi aia?aoo «Bioptrin»,
ai?iaaaeaeai? a EI? a?aeae?eaii? Ee?anueei? iaeanii? ee?i?/ii? e?ea?i?,
Oano?anuee?e oa Aaneeuee?anuee?e oeaio?aeueieo ?aeiiieo e?ea?iyo.

Iniaenoee aianie caeiaoaa/a iieyaa? a naiino?eiiio aecia/aii? iaoe oa
caaaeaiiy aeine?aeaeaiiy, i?iaaaeaii? cai?o iaoa??ae?a oa aiae?co
io?eiaieo ee?i?/ieo oa eaai?aoi?ieo aeaieo. Aea?? iaoiaeee, i?aai?caoe?y
iaoeiaeo aeine?aeaeaiue i?iaaaeai? i?ae ea??aieoeoaii aeieoi?a iaaee/ieo
iaoe, i?ioani?a A.A. ?nuee?aa. aeine?aeaeaiiy noaio caaaeueii?
?ioiieia?/ii? ?aaeoeaiino? aeeiiaii i?ae ea??aieoeoaii i?ia?aeiiai
iaoeiaoey IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie, aeieoi?a
iaaee/ieo iaoe A.N. Oei/aiei.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iniiai? iieiaeaiiy aeena?oaoe?? aeiiia?aeaeenue ? iaaiai?thaaeenue ia
can?aeaii? eaoaae?e ioi?eiiea?eiaieia?? Ee?anueei? iaaee/ii? aeaaeai??

i?neyaeeieiiii? ina?oe ?i. Ooieea (1996, 1998??.); iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Na?o caoe?a”-aeinyaiaiiy i?e?io??o?a?? a i?aeoeeo ioi?eii
ea?eiaieia?a Oe?a?ie”, i?enay/aii? 75-??//th eaoaae?e ioi?eiiea?eiaiei

a?? EIAII (Ee?a, 9-11 aa?aniy 1997 ?.); VII-eiia?an? na?oiai?
oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa (Oaeai?iae,1998?), ia
can?aeaii? Ee?anueei ai iaeaniiai oa i?nueeiai oiaa?enoaa
ioi?eiiea?eiaieia?a (1998 ?).

Ioae?eaoe??

Ia i?aenoaa? ?acoeueoao?a aeena?oaoe?eii? ?iaioe iioae?eiaaii 4 naiin
o?ei? ?iaioe: o?e a i?io?eueieo aeo?iaeao oa iaeia a iaoa??aeao
eiioa?aioe??.

No?oeoo?a oa ia’?i aeena?oaoe??

Aeena?oaoe?y neeaaea?oueny c anooio, 5 ?icae?e?a, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e oa nieneo aeei?enoaii? e?oa?aoo?e. ?iaioa aeeeaaeaia ia
145 noi??ieao iaoeiiieniiai oaenoo ?ethno?iaaia 26 oaaeeoeyie oa 8
?enoieaie. Iieaae/ee e?oa?aoo?e i?noeoue 363 aeaea?aea, c ieo 244
a?o/eciyieo oa e?a?i NIAe, ? 119 ca?oa?aeieo aaoi??a.

Ci?no ?iaioe

Iaoa??aee ? iaoiaee.

Aeey ae??oaiiy iinoaaeaieo caaaeaiue canoiniaaii noaoenoe/i?, ee?i?/i?,
?aioaaiieia?/i?, aaeoa??ieia?/i?, ?ioiieia?/i? iaoiaee aeine?aeaeaiiy.
Aea/aii oa i?iaiae?ciaaii 1316 ?noi??e oai?iae oai?eo c caiaeueieie
i?ioeanaie i?eiiniaeo iacoo ca 1981-1985, oa 1497 ca 1991-1995?iee ca
aeaieie EI?-ee?i?ee Ee?anueei? iaeanii? ee?i?/ii? e?ea?i?. Ianoaaeaiiy
aeeth/aei a naaa ca?? aiaiianoe/ieo aeaieo, caaaeueiiee?i?/ia
aeine?aeaeaiiy, a oiio /ene? aiae?ce e?ia?, na/?, aeai? ia’?eoeaiiai
iaeyaeo EI?–i?aai?a, ae?aaiinoe/i? ioieoe?? aa?oiueiuaeaiieo iacoo c
ianooiiei i?e?ia?ieia?/iei aeine?aeaeaiiyi ai?noo i?eiiniaeo iacoo.
I’yoe??/iee ia??iae i?ney aaa??? acyoi ia a ia?o? i’youe ?ie?a, a a
ianooii?, eiee iane?aeee aaa??? i?iyaeee naaa ae?aci?oa. Noaoenoe/i?
iaoiaee iaoeiaiai aiae?co aeeth/aee aea/aiiy caoai?thaaiino? ca a?eii,
noaooth, noi?iiith ii?aaeaiiy, aiaiianoe/ieie e?eoa??yie, aeaieie
ia’?eoeaiiai iaeyaeo EI?-i?aai?a.

I?e?ia?ieia?/ia aeine?aeaeaiiy aenoaeaoo i?eiiniaeo iacoo i?iaiaee ee a
aaeoa??ieia?/i?e eaai?aoi??? ia i?ci?oa 1-3 aiaeei c iiiaioo acyooy
aenoaeaoo. *ooeea?noue aeae?eaieo i?e?ii?aai?ci?a aecia/aee ca
iaoiaeeeith noaiaea?oieo iaia?iaeo aeene?a, i?ini/aieo ?ic/eiii
aioea?ioeeo, a?aeiia?aeii aei ?ino?oeoe?? IIC O?N? a?ae 22.10.1984 ?ieo.

?aioaai?anueea ianoaaeaiiy i?eiiniaeo iacoo i?iaiaeeeinue a iioe
ei/ii-eiai?e oa iioeee/ii-i?aeai??aeeia?e i?iaeoe?yo. Eiio?anooaaiiy
iacooe i?iaiaeeee ?ic/eiii eiaee?iieo. I?O-ianoaaeaiiy c?iaeai? a

oiiaao Ee?anueei? iaeanii? ee?i?/ii? e?ea?i? ia iaai?oii-?aciiainiiio
oiiia?ao? «Gyroscan T-5 NT» o??ie «O?e?in». Iaai?oii-?aciiainia
oiiia?ao?y aeeiioaaeenue a aeaio iniiaieo ieiueiao-ai?eciioaeuei?e oa
o?iioaeuei?e. C??ce a?ae eiaiaeo ai?a?a aeiieco, e?ie oiiia?ao?? 6 ii.,
oiaueia c??co 8 ii.

?ioiieia?/ia ianoaaeaiiy cae?enithaaeenue a eaai?aoi??? ?ioiieia??
Ee?anueei? iaeanii? ee?i?/ii? e?ea?i?. Aiae?c ?ioiiiai noaoono
i?iaiaeeee ca aeiiiiiaith iiiieeiiaeueieo aioeo?e aeey aeyaeaiiy
noaiiioeyoe?e ?ioiieiiiaoaioieo ee?oei o??ie «Orto Klon», NOA.
Aeine?aeaeaiiy neeaaeo ? aeni?an?? iiaa?oiaaiai oaiioeio
?ioiieiiiaoaioieo ee?oei i?iaiaeeee iai?yiei ?ioiioethi?anoeaioiei
iaoiaeii ca aeiiiiiaith iaiae? iiiieeiiaeueieo aioeo?e ia
?ioiieia?/iiio aiae?caoi?? ?-93. Aecia/aiiy ?ioiiaeiaoe?i?a i?iaiaeeee
ca iaoiaeeeith Iai/?i?, oaaioeeoa?io aeoea i?noue eaeeioeeo?a oa
oee?eoethth/? ?ioii? eiiieaene aecia/aee ca caaaeueii i?eeiyoeie
iaoiaeeeaie (Ia?aaea??e A.A. ? ni?aaao. 1995).

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy

E?euee?noue oai?eo c aino?eie ? o?ii?/ieie caiaeueieie i?ioeanaie
i?eiiniaeo iacoo aini?oae?ciaaieo a EI? ee?i?eo, aoea 1316 (13,99%) a
1981-1985 ?ieao, ? 1497 (20,69%) a 1991-1995??. A 1981-1985 ?ieao a
noaoe?iia?? c 9401 aini?oae?ciaaieo a EI? a?aeae?eaiiy, c o?ii?/ieie
caiaeue ieie i?ioeanaie i?eiiniaeo iacoo i?ie?eiaaii 925, ui neeaei
9,84% an?o oai?eo, a a 1991-1995??. c 7234 — 878 aai 12,14%
a?aeiia?aeii. Oaeei /eiii, c?inoaiiy e?eueeino? o?ii?/ieo caiaeueieo
i?ioean?a i?eiiniaeo iacoo a i?neyaaa??eiee ia??iae neeaei 2,3 %.
(t=4.68, ?<0.01). Iaeiia?/iee i?ioean ae?aaiinoiaaii o 33,8%, aeaia?/iee o 66,2% oai?eo o 1981-1985 ?ieao oa o 31,3% oa 68,7% o 1991-1995 ?ieao., oiaoi a?aenioie oai?eo c aeaia?/iei o?ii?/iei caiaeueiei i?ioeanii i?eiiniaeo iacoo aoa noaoenoe/ii aeinoia??ii aeua, i?ae c iaeiia?/iei i?ioeanii ye o 1981-1985 ?.(t=14.72 p<0.001) oae ? o 1991-1995 ?.(t=16.84 p<0.001). O??o?a?/ia e?eoaaiiy i?iaaaeaii o 77,1% o 1981-1985 ?ieao, oa 58,8% o 1991-1995 ??., ui noaoenoe/ii aeinoia??ii ieae/a o 1991-1995 ?.(t=8.46 p<0.001). . Aiae?c aaaeeino? ia?aa?ao o?ii?/ieo caiaeueieo i?ioean?a i?eiini aeo iacoo, a yeeo i?ioean ia noi?iaiaeaeoaaany oneeaaeiaiiyie, iieacaa, ui o 1981-1985 ?ieao oaeeo oai?eo aoei 917, aai 99,14%, a o 1991-1995 ??. 846, aai 96,36% oai?eo a?aeiia?aeii, o a?aeiioaii? aei an?o oai?eo c o?ii?/ieie caiaeueieie i?ioeanaie i?eiiniaeo iacoo. ?acii c oei, e?euee?noue o?ii?/ieo caiaeueieo i?ioean?a i?eiiniaeo iacoo a i?neyaaa??eiiio ia??iae?, a naia ca 1991-95 ?iee, ye? noi?iaiaeaeoaaeenue na?eicieie oneeaaeiaiiyie, c?inea. sseui, a 1981-1985 ?ieao a?aenioie oaeeo oai?eo o a?aeiioaii? aei an?o oai?eo c o?ii?/ieie caiaeueieie i?ioeanaie i?eiiniaeo iacoo aoa 0.86, oi a 91-95 ??.-3,64, oiaoi c??n o 4,23 ?ace (t=3.97 p<0.05), a?aeiia?aeii aeinoia??ii ciaioeany a?aenioie oai?eo c iaoneeaaeiaieie o?ii?/ieie neioneoaie (t= 3.87 p<0.05). Caa?oa? ia naaa oaaao oa, ui oaea c?inoaiiy caiaeueieo i?ioean?a i?eiiniaeo iacoo c oneeaaeiaiiyie, i?eiaaea? ia iaei?iaeoeoeai?oo a?eiao a?oio, a naia 16-60 ?ie?a. sseui a 81-85 ?ieao, oneeaaeiaiiy a oe?e a?eia?e a?oi? neeaaeaee 0,75%, oi o 91-95 ?ieao, oey oeeo?a c?inea aei 3,3%, oiaoi ca?eueoeeany a 4,4 ?ace. Ca eieae?caoe??th i?ioeano, ?cieueiaaia o?ii?/ia caiaeaiiy aa?oiuei uaeaiii? iacooe a 1981-1985 ?ieao aoei o 26,3% oai?eo, a o 1991-1995 – o 41,35%.(t=6.62, p<0.001). Aea/aiiy aeeiai?ee ia?aa?ao o?ii?/ieo caiaeueieo i?ioean?a i?eii niaeo iacoo, iieacaei, ui o?ii?/iee aa?oiueiuaeaiiee neioneo /anoi ii?aeio?oueny c caiaeueieie i?ioeanaie a ?ioeo i?eiiniaeo iacooao, oa noi?iaiaeaeo?oueny oeie /e ?ioeie oneeaaeiaiiyie Oae, o ii?aeiaii? c iie?iiciei aoii?aeeoii o?ii?/iee aa?oiueiuaeaiiee neioneo niinoa??aaa ny o 57,87% oa 43,07% oai?eo a?aeiia?aeii, c o?iioeoii o 1981-1985 ?ieao o 3,62% oai?eo, a o 1991-1995 – 7,36 p<0.05), c eenoith aa?oiueiuaeaiii? iacooe o 11,21% oa 4,29% oai?eo. A i?neyaaa??eiiio ia??iae?, c?inea e?euee?noue o?ii?/ieo neioneo?a aa?oiueiuaeaiieo iacoo, oa a ii?aeiaii? c caiaeueieie i?ioeanaie a ?ioeo i?eiiniaeo iacooao, ye? noi?iaiaeaeoaaeenue na?eicieie oneeaaeiaiiyie. A 1981-1985 ?ieao a?aenioie oaeeo oai?eo o a?aeiioaii? aei an?o oai?eo c o?ii?/ieie caiaeueieie i?ioeanaie aa?oiueiuaeaiieo iacoo aoa 0,91 (8 ae iaaee?a ia 883 oai?eo ), oi a 91-95 ??. - 3,93 (32 ia 815), oiaoi c??n o 4,32 ?ace (t=4.01 p<0.01). Oae naii, ye ? a a?oi? c caiaeueieie i?ioeanaie i?eiiniaeo iacoo, c?inoaiiy e?eueeino? o?ii?/ieo caiaeueieo i?ioean?a a aa?oiueiuaeaiieo iacooao, ye? noi?iaiaeaeoaaeeny oneeaaeiaiiyie, i?eiaaea? ia iaei?iaeoeoea i?oo a?eiao a?oio, a naia 16-60 ?ie?a. sseui a 81-85 ?ieao, oneeaaeiaiiy a oe?e a?eia?e a?oi? neeaaeaee 0,68% oi o 91-95 ?ieao, oey oeeo?a c?inea aei 3,19%, o a?aeiioaii? aei an?o oai?eo c o?ii?/ieie caiaeueieie i?ioeanaie a aa?oiueiuaeaiieo iacooao, oiaoi ca?eueoeeany a 4,69 ?ace (t=4.01 p<0.01). Iniiaieie nea?aaie i?e o?ii?/ieo aa?oiueiuaeaiieo neioneoao aoee: cao?oaeiaia iiniaa aeeoaiiy o1981-1985 ??. o 741 oai?iai, aai 84%, o 1991-1995–709, (87%), aieiaiee a?eue-a?aeiia?aeii o 698 (87%), oa 668 (82%), aeae?eaiiy c iina o 663 (75%), ? o 636 (78%), aie? a iaeano? i?iaeoe?? iacoo o 275 (31%) ? 277 (34%), a?iini?y o 167 (19%) oa 179 (22%). Ia oa?i?i caoai?thaaiiy, yeee neeaaeaa a?ae iaeiiai aei aeanyoe ?ie?a aeacoaaee 79% oai?eo o 1981-1985 ?ieao oa 85% o 1991-1995??. Aee?eaeaiiy iiniai? ia?aae?eee aeyaeaii o 689 iaoe??io?a (78%) o 1981-1985 ?ieao oa 677 (83%) o 91-95 ?ieao, iaa?ye neeciai? iaieiiee aeyaeaii o 1981-1985 ?ieao o 671 oai?iai (76%) ? o 1991-1995??., o 636 (78%), a?ia?o?io?y na?aaei?o iiniaeo ?aeiaei a?aeiia?aeii o 592 (67%) oa o 562 (69%), aeae?eaiiy c iina – o 548 (62%) ? 530 (65%), iie?ie ii?iaeieie iina o 433 (49%) ? 457 (56%). Aenoaeaoeai? oi?ie o?ii?/iiai aaeii?eoo aoee o 1981-1985 ?ieao o 330 oai?eo (37,3%) ? o 336 (41,2%) o 1991-1995??., ui noaoenoe/ii ia a?ae??ciyeinue. iae/ano?oa aoa o?ii?/iee ai?eiee aaeii?eo –o 57% oa 62%, eaoa?aeueia oi?ia-o 21% oa 24% ? o 22% ? 14% -na?icia. Ca aiaiianoe/ieie aeaieie o 55% o 1981-1985 ?ieao oa o 58 % aeiaaee?a a 1991-1995??. a?i aeiee ia a?oio? aino?iai ai?eiiai aaeii?eoo, i?e/eiith yeiai aoee aino?? ?ani??aoi?ii-a??oni? oa i?inooaei? caoai?thaaiiy, o 22% o 1981-1985 ?ieao oa o 23%- a 1991-1995??. i?ioean iaa iaeiioiaaiia iioiaeaeaiiy, o 23% oa 19% ci?oaiiai oa?aeoa?o, ine?eueee a oeeo iaoe??io?a aoee ea??ici? coae, caaino?aiiy o?ii?/iiai ia?eiaeiioeoo, a oaeiae ?ani??aoi?i? caoai?thaaiiy. I?iaeoeoeai? oi?ie caoai?thaaiiy cono??/aeenue o 553 oai?eo (62,7%) a 1981-1985 ?ieao, ? o 479 (58,8%) a 1991-1995 ??., ui noaoenoe/ii aeinoia??ii ia a?ae??ciyeinue. C ieo iie?iiciee neioneo aoa o 52,5%, oa a o 57,2%, i?eno?ieiai-a?ia?ieanoe/iee o 37,4% oa o 33,8%, ?io? oi?ie (oieanoaaoiiia, eacaicia, iae?ioe/ia), o 10,1% oa o 9% oai?eo a?aeiia?aeii. Ca ee?i?/iei ia?aa?aii eaaea oi?ia caoai?thaaiiy niinoa??aaeany o 39,6% o 1981-1985 ?ieao oa 35,2% 1991-1995??. Aiia oa?aeoa?ecoaaeanue caaaeueiei caaeia?eueiei noaiii, ii?iaeueiith oaiia?aoo?ith o?ea, nea?aaie ia cao?oaeiaiiy iiniaiai aeeoaiiy, ianeoaiiy ai?eieo e??i/ie. I?e ?eiineii?? a?aei?/aee iii??io nooi?iue iaa?yeo, a?ia?ai?? neeciai? iaieiiee na?aaeiuei? iiniai? ?aeiaeie, iacia/io e?euee?noue ai?eieo aeae?eaiue aai noo? ai?ei? e??i/ee a na?aaeiueiio iiniaiio oiae?. I?e iaeiioiaaiiiio i?ioean? ci?ie i?e ?eiineii?? aoee iacia/ieie, iinia? oiaee aoee /enoeie, ui aeicaiey? aeoiaoe, ui o?ii?/iee iaeiioiaaiiee neioneo ia? i?eoiaaiee (eaoaioiee) ia?aa?a, iniaeeai i?e ii/aoeiaeo noaae?yo eiai ?icaeoeo, ? o?eueee ?aioaaiia?ao?y, EO aai I?O aeicaiey? aeyaeoe o?aaeaiiy aa?oiueiuaeaiii? iacooe. I?e iaiaeiioiaaiieo neioneoao ia? i?noea iaoai?ci ?icaeoeo, i?e yeiio aaaeeeaiai cia/aiiy iaaoaa? iano?oeoe?y i?e?iaeiiai ioai?o iacooe. Ia?ae?eooy aea?aeiiai ioai?o i?eaiaeeoue aei o?ainnoaeaoe?? ex vacuo, o iiaeaeueoiio ianooia? i?e?aeiaiiy aaeoa??aeueii? oei?e, iiyaey?oueny ai?eiee aenoaeao. Ee?i?ea o?ii?/iiai ai?eiiai neioneoo na?aaeiuei? aaaeeino?, yeee aeyaeaii o 59,5% oai?eo 1981-1985 ?ieao oa o 60,9% o 1991-1995??, oa?aeoa?ecoaaeanue yaeuaie ia??iaee/iiai caaino?aiiy o?ii?/iiai i?ioeano, i?aeaeuaiiyi oaiia?aoo?e o?ea, ?ioieneeaoe??th, iiieaeaiiyi i?aoeacaeaoiino?, iineeaiiyi ai?eieo aeae?eaiue ?c iina. I?e ?eiineii?? a?aei?/aee iaa?ye, a?ia?ai?th neeciai? iaieiiee na?aaeiuei? iiniai? ?aeiaeie, cia/io e?euee?noue ai?eieo aeae?eaiue a na?aaeiueiio iiniaiio oiae?. A i?neyaaa??eiiio ia??iae?, a naia ca 1991-1995 ?iee c?inea e?euee?noue aaaeeeo oi?i o?ii?/ieo neioneo?a aa?oiueiuaeaiieo iacoo, ye? a ii?aeiaii? c caiaeueieie i?ioeanaie a ?ioeo i?eiiniaeo iacooao, noi?iaiaeaeoaaeenue na?eicieie oneeaaeiaiiyie. Ee?i?/ii oae? oi?ie caoai?thaaiiy oa?aeoa?ecoaaeenue yaeuaie caaino?aiiy o?ii?/iiai i?ioeano, noi?iaiaeaeoaaeeny noaia??inoaeueiei aanoeanii, iaa?yeii iia?e, aanoeanii aai oeaaiiiith ?ao?iaoeueaa?ii? ee?oeiaeie, aioo??oiuei/a?aiieie oneeaaeiaiiyie. Aaeoa??ieia?/ia aeine?aeaeaiiy aenoaeaoo aa?oiueiuaeaiieo iacoo io?eiaiiai i?e ia?o?e ioieoe?? i?iaaaeaii o 557 (63%) oai?eo o 1981-1985??. oa o 587(72%) a 1991-1995??. c?inea ?ieue noao?eieieo a aeieeiaii? o?ii?/iiai aa?oiueiuaeaiiiai neioneoo. sseui o 1981-1985 ??. noao?eieie neeaaeaa 56,2% aen?yii? i?e?ioei?e, oi a 1991-1995 ??.-71,2%. Uiaei /ooeeaino? i?e?ioei?e, oi ca?aeii io?eiaieo iaie aeaieo, a ia?aaaaei?e a?eueoino? iin?a?a i?e?ioei?a aoea iaei/ooeeaa aei iae?iniianthaeaeai?oeo aioea?ioee?a (iai?oeee?io (9,1% o 81-85??., oa 7,6% o 91-95??.), ienaoeee?io (9,5% o 81-85??., oa 8,3% o 91-95??.), eaiai?oeeio (3,2% o 81-85??., oa 2,5% o 91-95??.), ea?aai?oeee?io (5% o 81-85??., oa 2,6 o 91-95??.), eaaii?oeaoeio (9,8% o 81-85??., oa 7,4% o 91-95??.), e?ieii?oeeio (2,8% o 81-85??., oa 2,2% o 91-95??.), iie?i?eneio (2,6% o 81-85??., oa 1,6% o 91-95??.), oao?aoeeee?io (2,2% o 81-85??., oa 1,3% o 91-95??.). Aeaui aeua /ooeea?noue i?e?ioei?e aei aii?oeee?io (13,6% oa 11,1%), aaioai?oeeio (34,5% oa 20,4%), a?aeiia?aeii o 1981-1985 oa 1991-1995??.. Iaea?eueo /ooeeaith i?e?ioei?a aoea aei aioea?ioee?a oeaoaeinii?eiiaiai ?yaeo: ia?oiai iieie?iiy-oeaoacie?i (29,4% o 1981-1985??), (aoeao, eaocie) oeaoaeaen?i. *ooeea?noue i?e?ioei?e aei oeaoaeinii?ei?a ae?oaiai-/aoaa?oiai iieie?iiy a ca’yceo c a?aenooi?noth aeene?a ia i?iaiaeeeanue, oi/a ee?i?/ia canoinoaaiiy oeaoiaoacieo oa oeaoi??iio aeaaaei iiceoeaiee aoaeo. Iaie i?iaaaeaia ioe?iea ?ioiieia?/ieo aeaieo o 49 in?a a aeiaaa??eiee ia??iae. ?c ieo o-35 caei?iaeo oa 14 c o?ii?/iei aa?oiueiuaeai iei neioneoii. a i?neyaaa??eiee ia??iae ?ioiieia?/ia aeine?aeaeaiiy i?iaaaeaii o 41 iniae a oiio /ene? - 26 - c o?ii?/iei aa?oiueiuaeaiiei neioneoii, oa 15 caei?iaeo (eiio?ieueia a?oia). C ieo in?a /ieia?/i? noao? aoei 26, ae?ii/i?- 15. A?e ianoaaeaieo aoa a?ae 14 aei 65 ?ie?a. Aeai? aoii?aeueiiai ?ioi?oaoo o oai?eo c o?ii?/iei aenoaeaoeaiei neioneoii, io?eiai? o 1981-1985 ?ieao, oa?aeoa?ecoaaeenue oaeeie e?euee?nieie iieacieeaie: oae i?e aecia/aii? ni?aa?aeiioaiiy A-e?ioioeeo?a o 21 caei?iaiai oa o 14 oai?eo in?a, ?o e?euee?noue o eiio?ieuei?e a?oi? aei??aithaaea 22,8 % ± 0,48, oiae? ye o oai?eo - 29,8 % ± 0,7 (? < 0,001). ?ioiiaeiaoe?ie A, I, G aecia/aii o 35 caei?iaeo oa o 14 oai?eo iaoe??io?a. E?euee?noue Ig A aei??aithaaea 3,34 ± 0,303 a?/e o caei?iaeo oa 2,69 ± 0,25 a?/e o oai?eo (? < 0,05). ?g I neeaa 1,2 ± 0,129 a?/e oa 1,81 ± 0,36 a?/e (?< 0,05) a?aeiia?aeii, Ig G - 12,88±0,55 a./e oa 12,11±0,86 a?/e (?>0,05) a?aeiia?aeii o caei?iaeo ? oai?eo Oaeei
/eiii, e?euee?noue A-e?ioioeeo?a ye o a?aeiiniiio oae ? a aaniethoiiio
ia/eneaiiyo aoea noaoenoe/ii aeinoia??ii i?aeaeuaiith. Eiioeaio?aoe?y Ig
G nooo?ai ia a?ae??ciyeanue a?ae ii?ie, a ni?aa?aeiioaiiy Ig
A–aeinoia??ii cieaeoaaeinue, a oie /an ye e?euee?noue Ig I
i?aeaeuoaaeanue. E?euee?noue e?ioioeeo?a o a?oi? 21 caei?iaiai
aei??aithaaea 28%±1,09 oa 27,4%±0,9 (?<0,6) o oai?eo, O-e?ioioeeo?a 57%±0,73 oa 45,1%±1,5 (?< 0,001), O-aeoeaieo-35,8%±0,51 ? 28,7%±1,3 (?<0,001), I-e?ioioeeoe - 20,2%±0,8 oa25,1%±1,8(?< 0,02) a?aeiia?aeii o caei?iaeo oa oai?eo, oiaoi ni?aa?aeiioaiiy ye O-e?ioioeeo?a, oae ? O- aeoeaieo e?ioioeeo?a aoei aeinoia??ii cieaeaiei o oai?eo ia o?ii?/iee aa?oiueiuaeaiiee neioneo. O 1991 – 1995 ?ieao i?iaaaeaii ?ioiieia?/ia ianoaaeaiiy o 15 caei?iaeo oa 26 oai?eo c o?ii?/ieie aa?oiueiuaeaiieie neioneoaie. O oai?eo a?oie 14–39 ?ie?a, e?euee?noue Ig I a ii?i? neeaaeaea 2,51±0,2a?/e, a i?e iaoieia?? – 1,13±0,055 a?/e (?< 0,05), Ig G –14,8 ± 0,9 a?/e oa 8,77 ±0,426 a?/e (?<0,05) a?aeiia?aeii. O-e?ioioeeoe a ii?i? aei??aithaaee 66,3%±2,04 ? 59,23 %± 0,764 (?<0,05), O-oaeia?e 45,3%±1,6 oa 31,235%±0,824 (?< 0,001), O- noi?ani?e 39,0%±2,3 oa 24,58% ±0,624 (?<0,05), O- e?eea?e 17,9%±1,4 ? 20,47%±0,354 (?> 0,05).Oaaioeeoa?iee
iieaciee a ii?i? aoa 90,0%±7,0 , a i?e iaoieia?? 54,05%± 1,737
(?<0.001), a oaaioeeoa?iee ?iaeaen 10,0%±0,5 oa 7,41%±0,333 (?<0,05). Ni?aa?aeiioaiiy Oe?E neeaaeaei a ii?i? 118±6,1, a o oai?eo c neio?oaie 47,29±2,99 (?< 0,05).I?e aea/aii? ni?aa?aeiioaiiy ee?oei ooieoe?iiaeueii iaiaeii??aeii? iiioeyoe?? O-e?ioioeeo?a anoaiiaeaii, ui e?euee?noue O-ee?oei–e?eea??a, ye a a?oi? oai?eo a?eii a?ae 14 aei 39 ?ie?a (20,47 ± 0,354%), oae ? a ae?oa?e a?oi?, neeaea 22,33 ± 0,745% i?e ii?i? 17,9 ±1,4%. E?euee?noue O-ee?oei-oaeia??a, aoea noaoenoe/ii aeinoia??ii cieaeaia a iaio a?oiao oai?eo - 31,235 ± 0,824% ( ?< 0,001) oa 30,77 ±1,064 % (?< 0,05) i?e ii?i? 45,3±1,6%. I?e aea/aii? e?eueeino? noi?ani?ieo O-ee?oei, aoei anoaiiaeaii, ui ni?aa?aeiioaiiy ?o cia/ii cieaeaii, ye a ia?o?e a?oi? – 24,58 ± 0,624% (?<0,05) oae ? a ae?oa?e–26,55±1,237 (?<0,001) i?e ii?i? 39,0 ± 2,3%. Oaaioeeoa?iee iieaciee o oai?eo iaio a?oi aoa aeinoia??ii cieaeaiee ? noaiiaea 54,05 ± 1,737% (?< 0,01) oa 61,11 ± 3,259% (?< 0,05) a?aeiia?aeii, i?e ii?i? 90,0±7,0%. A ?iaio? aoei oaeiae aea/aii ni?aa?aeiioaiiy oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E), ye? ni?eythoue ooai?aiith ??ciiiai?oieo iioeiaeaeaiue oeaiei, neeciaeo iaieiiie, ni?e/eiaieo a?aeeeaaeaiiyi a inoaii?o eiiieaen?a aioeaai-aioeo?ei. Iaie aeyaeaii cieaeaiiy Oe?E o an?o oai?eo o?ii?/iei aa?oiueiuaeaiiei neioneoii, ye a a?oi? a?eii 14-39 ?ie?a- 47,29±2,99 (?< 0,05), oae ? a a?oi? 40-65 ?ie?a – 51,66 ± 6,44(?< 0,05). Aea/aiiy aoii?aeueiiai ?ioi?oaoo iieacaei, ui ai?no Ig A nooo?ai ia a?ae??ciyany a?ae iieaciee?a eiio?ieueii? a?oie ? neeaa 1,57±0,122 (?>0,05) oa 1,97±0,146 a iaio a?oiao. Eiioeaio?aoe?y Ig G, ui neeaaea?
iniiaio iano ne?iaaoeiaeo ?ioiiaeiaoe?i?a (70-80%) aoea cia/ii cieaeaia.
O oai?eo c o?ii?/iei ai?eii-a?ia?ieanoe/iei aaeii?eoii a?aei?/aeinue
noaoenoe/ii aeinoia??ia cieaeaiiy ??aiy iae?iaeiaoe?i?a I-1,13±0,055
(?<0,05) oa 1,015±0,082 i?e 2,51±0,2 a ii?i?. Iiaeeeai, ui i?e oae?e iaoieia?? i?aai?ci ia a ciic? ae?iaeoe aeinoaoith e?euee?noue aioeo?e eeano IgM, eio?? a ni?eyee iiaeeiaiith aaeoa??? ? iaeo?ae?caoe?? ?o oienei?a. Iaie i?iaaaeaii oaeiae ei?aeyoe?eiee aiae?c iieaciee?a ?ioi?oaoo. E?euee?noue iaaeiaaeeiaeo (aeinoia??ieo)eiao?oe??io?a ei?aeyoe?? aeey a?oie 40-65 ?. neeaea 7(11%), aeey a?oie 16-39?.- 23 (33,3%) (t=3,21 p<0.01), ui aeicaiey? c?iaeoe i?eiouaiiy, ui a a?oe? 14-39?.?ioiieia?/i? iieacieee a?eueo nei?aeueiaai? i?ae niaith. ?aioaaiieia?/ia ianoaaeaiiy i?iaaaeaii 645(73%)oai?ei c aa?oiueiuaeaiiei neioneoii o 1981-1985??.oa 625 (76,7%) o 1991-1995??. Oioaeueia caoaiiaiiy iacoo ia iaeyaeia?e ?aioaaiia?ai? eiinoaoiaaia o 78 (12,1%) ianoaaeaieo o 1981-1985??. oa o 88 (14,1%) o 1991-1995??, i?eno?ieiaa iioiauaiiy neeciai? iaieiiee iacoo o 420 oai?eo (65,1%), o 1981-1985??., oa 419 - (67%) o 1991-1995??, caoaiiaiiy ieaei?o a?aeae?e?a aa?oiueiuaeaiieo neion?a - o 147-(22,8%) o 1981-1985??., ? 118-18,9% o 1991-1995 ?ieao. A 1981-1985 ?ieao c 553 oai?eo c i?iaeoeoeaieie oi?iaie caoai?thaaiiy eiio?anoia ?aioaaiia?ao?y a aeaio i?iaeoe?yo i?iaaaeaia o 375 (67,8%), a a 1991-1995 c 479 oai?eo–382(79,7%) oai?ei. Ia ?aioaaiia?aiao eiinoaoiaaia iayai?noue iie?iiciiai i?ioeano a aa?oiueiuaeaiieo iacooao–ia??aiii??ia iie?iiiiae?aia iioiauaiiy neeciai? iaieiiee iacooe-o 1981-1985 ?ieao o 52% ianoaaeaieo, a o 1991-1995??.-o 55,5%. Ae?aaeaiee i?eno?ieiai-a?ia?ieanoe/iee i?ioean–i?eno?ieiaa iaoa?oaaiiy ia ??aiii??ii? oiaueie aei 3-4 ii. c /?oeeie, aea ia??aieie eiioo?aie - aoa o 38,8% oa 35,3%, ?aioaaiieia?/i? ci?ie o aeaeyae? iioiauaiiy ie?oaei? oi?ie c aeaaeeeie e?ayie- 11,2% oa 9,2% oai?eo a?aeiia?aeii o 1981-1985 ??. oa 1991-1995 ?ieao. A 1981-1985 ?ieao c 330 oai?eo c aenoaeaoeaieie oi?iaie caoai?thaaiiy eiio?anoia ?aioaaiia?ao?y a aeaio i?iaeoe?yo i?iaaaeaia o 123 (37,3%), a a 1991-1995 c 336 oai?eo – 156 (46,4%) oai?ei. Iayai?noue aenoaeaoo oa iii??ia iioiauaiiy neeciai? iaieiiee iacoo o oai?eo aenoaeaoeaieie oi?iaie o?ii?/iiai aa?oiueiuaeaiiiai neioneoo eiinoaoiaaia o 111 (52,6%) o 81-85 ?ieao, oa o 165 (69,3%) o 91-95 ??. I?iaiae?ciaaii 525 I?O, ianoaaeoaaieo oai?eo a EIEE o 1997 ?ioe?. C ieo in?a /ieia?/i? noao? aoei 330, ae?ii/i? – 195. Ca a?eii: 10–14 ?ie?a aoei 80 (15,2%), 14–65 ?ie?a 445 (84,8%). Ci?ie a aa?oiueiuaeaiieo iacooao aeyaeaii o 79 (13,1%) ianoaaeaieo. O 68 iaoe??io?a ia neaiao I?O aeyaeaii i?eno?ieiaa no??/eiiiae?aia i?aeaeuaiiy ?ioaineaiino? caoaiiaiiy oa i?aeaeuaiiy neaiaeo ia O-2 caaaeaieo cia?aaeaiiyo. A?eueo?noue iaoe??io?a ianoaaeoaaeeny c iaoith aeyaeaiiy iae?io??o? a?/ii? iaoieia??. Nea?a, ye? a aeacoaaee ia iayai?noue iaoieia?? aa?oiuei uaeaiieo neion?a aeiaeai c ieo ia i?aae'yaeya Oaeei /eiii, o eiaeiiai nueiiiai ianoaaeaiiai c oeo ye? ia i?aae'yaeyee nea?a ia EI? iaoieia?th, i?e I?O-neaioaaii? aeyaeaii caoaiiaiiy aa?oiueiuaeaiieo neion?a. Oaeoeea e?eoaaiiy o?ii?/ieo aa?oiueiuaeaiieo neioneo?a caeaaeaea a?ae oi?ie caoai?thaaiiy, iioe?aiiy i?ioeano oa eiai o?eaaeino?, iayaiino? noiooiuei? iaoieia??, noaio ?ioiieia?/ii? ?aaeoeaiino?, aea?a??. E?eoaaiiy eaaei? oi?ie o?ii?/iiai ai?eiiai neioneoo aoei iai?aaeaii ia naiaoe?th iacooe, a?aeiiaeaiiy ooieoe?iioaaiiy i?e?iaeiiai aea?aeiiai ioai?o. I?e oeueiio ao?io?iiia e?eoaaiiy canoiniaoaaeinue o?eueee i?noeaai, aeey /iai cae?enithaaee ae?aioaaiiy iacooe. Ae?aiaaeiee iaoiae e?eoaaiiy canoiniaaiee o 95,6% oai?eo o 1981-1985 ?ieao oa a 98,9% oai?eo o 1991-1995 ??, o?ii?/iei ai?eiei aa?oiueiuaeaiiei neioneoii. O?eaae?noue e?eoaaiiy ae?aiaaeiei iaoiaeii noaiiaeea: aei 7 aei?a - o 35% a 1981-1985 ?ieao ? o 47% 1991-1995??., 8-10 aei?a - o 34% oa 30%, a?aeiia?aeii, ? a?eueoa10aei?a-31% oa 23% aeiaaee?a. C 1991?ieo canoiniaoaaee oiiioi?ac e?ea?nueeeo cania?a (?ic/ei aioea?ioeea c a?ae?iei?oeciiii, yeee aaiaeeee a iacooo) a ii?aeiaii? c ei?oeeinoa?i?aeieie iacyie, yeeie i?ini/oaaee oaiiii ui aaiaeeany a ii?iaeieio iina. *anoioa oeueo?acaoeiaeo eieeaaiue 2640 eAoe, ?ioaineai?noue–0,6-0,8 Ao./ni2, ?aaeei ?iaioe–aacia?a?aiee. *an i?iaaaeaiiy i?ioeaaeo?e –10 oaeeei, uiaeaiii, e?euee?noue i?ioeaaeo? - 8-10. Canoinoaaiiy ii?aeiaii? iaoiaeeee aaaaeaiiy e?e?a c aeiiiiiaith aiaeiiacaeueiiai oiiioi?aco aeicaiey? ca ei?ioeee /an aeiaeoeny iie?auaiiy i?io?aeiino? ii?iaeieie iina, ? i?e?iaeiiai aea?aeiiai ioai?o aa?oiueiuaeaiiiai neiona, ine?eueee ciaioo?oueny ? i?ioiaeeoue iaa?ye, a?ia?ai?y neeciai? iaieiiee. E?eoaaiiy ai?eiiai neioneoo na?aaeiuei? aaaeeino? aeiaaaei i?ecia/aiiy caaaeueii? aioeaaeoa??aeueii? oa?ai??, aeac?ioieneeaoe?eieo cani a?a ? ia?aeaeueii c oeei canoiniaoaaany ae?aiaaeiee iaoiae. I?e iaeiioiaaiieo oi?iao neioneoo i?iaiaeeeanue naiaoe?y coa?a, yea cae?enithaaeanue ia?aeaeueii c i?noeaaei ae?aiaaeiei iaoiaeii e?eoaaiiy. Aoaeoeai?noue e?eoaaiiy aenoaeaoeaieo oi?i o?ii?/iiai aaeii?eoo aeinyaea 69% oai?eo o 1981-1985 ?ieao, oa 77% o 1991-1995??. a?aeiia?aeii. C ieo o 19% oa 22%- aecaei?iaeaiiy, oa o 50% ? 55% a?aeiia?aeii-iie?auaiiy. E?eoa??yie aecaei?iaeaiiy aaaaeaeanue a?aenooi?noue ?aoeeaeea?a caoai?thaaiiy a?eueoa ?ieo, iie?auaiiyi -?aoeeaeeae ia a?eueoa 1-2 ?ac?a ia ??e, ? c iacia/ii ae?aaeaiith neiioiiaoeeith. Ca?eueoaiith iiceoeaiiai aoaeoo eiiieaeniiai ae?aiaaeiiai iaoiaeo e?eoaaiiy (77%), a 1991-1995 ?ieao, ia iaoo aeoieo, ni?eyei canoinoaaiiy ii?aeiaii? iaoiaeeee aaaaeaiiy e?e?a c aeiiiiiaith aiaeiiacaeueiiai oiiioi?aco. A oeo aeiaaeeao, aea o?ii?/iee aaeii?eo noi?iaiaeaeoaaany o?iioeoii, aoii?aeeoii, aee?eaeaiiyi ia?aae?eee iina, aaeaii?aeieie aaaaoaoe?yie, i?iaiaee eenue iia?aoeai? ao?o/aiiy. I?e i?iaeoeoeaieo oi?iao caoai?thaaiiy oaeoeea e?eoaaiiy a?ae??c iyeany a?ae oaeoeea e?eoaaiiy aenoaeaoeaieo oi?i. I?e iaiaaeaiiio iie?iiciiio i?ioean? e?eoaaiiy oaeiae ii/eiaee c ae?aiaaeiiai iaoiaeo, ia?aeaeueii i?iaiaey/e oiiioi?ac ca aeuaiienaiith iaoiaeeeith. Aoaeo niinoa??aaee /a?ac 3-4 naaine: ciaioaiiy iaa?yeo neeciai? iaieiiee, iie?i?a, iie?auaiiy iiniaiai aeeoaiiy, ui aeaaaei iiaeeea?noue a?aeiiaeoeny a?ae iia?aoeaieo ao?o/aiue. O??o?a?/ia ao?o/aiiy i?iaaaeaii i?e i?iaeoeoeaieo oi?iao neione oo aa?oiueiuaeaiieo iacoo oa a ii?aeiaii? c caiaeueieie i?ioeanaie a ?ioeo i?eiiniaeo iacooao o 1981-1985 ?ieao o 54,2% oa o 1991-1995 ?ieao o 57,5% oai?eo. Iiooee iiaeo cania?a e?eoaaiiy, ye? aeathoue ciiao i?aai?cio aeanieie neeaie iiaeaaeyoe iaoieia?/iee i?ioean, aeicaieythoue iaiaaeeoe aaeeaaiiy aioea?ioee?a, caeeoathoueny aeooaeueieie. E?i?eii-iiey?eciaaia na?oei eaiie "A?iio?ii", yea aei?ii?ith? oaee? a ae?aiacii? a?ae aeaeeiiai aei neaai c?a??aath/iai ?io?a/a?aiiiai, ?ioaineai?noth 40 iAo/ni2, c uioaeeeiiith aia?a??th –2,4 Aeaeni2. ia? aeanoeaino? ?ioiiiiaeoeyoi?a (Kubasova T., et al., 1995). Canoinoaaiiy eaiie "A?iio?ii" a Oe?a?i? aeicaieaii ?a?no?aoe?eiei iina?ae/aiiyi i?i?noa?noaa ioi?iie caei?ia'y ? 405/97 a?ae 6 aeiaoiy 1997 ?. Ia a?aei?io a?ae eaca?a, yeee ciaeoia oe?iea canoinoaaiiy a eiiieaeniiio e?eoaaiiy o?ii?/ieo aa?oiueiuaeaiieo neioneo?a, na?oei, ui iiey?eco?oueny ca aeiiiiiaith eaiie a?iio?ii, ia? aaeeeo oe?eio oaee? (400-2000 ii), ? iie?o?iiaoe/iei ? ia? iaeo aia?a?th (?ieiaa?aioi?noue), a i?aeoeoe? e?eoaaiiy neioneo?a ia canoini aoaaeiny. Eiiieaenia e?eoaaiiy a?oie oai?eo aeeth/aei a naaa ioieoe?th aa?oiueiuaeaiii? iacooe c aaaaeaiiyi a ia? ?ic/eio oeaoacie?io, noniaic?? a?ae?iei?oeciio, ae?aioaaiiy ?? oaoeiiiaith o?oai/eith oa i?iaaaeaiiyi ii?ii?iaiiy eaiiith "A?iio?ii-2" ia i?ioyc? 8-10 oaeeei aea?/? a aeaiue ia iaeanoue i?iaeoe?? iacoo. Aoaeoeai?noue canoinoaaiiy eaiie "A?iio?ii-2" o oe??? a?oie oai?eo ii??aithaaee c a?oiith oai?eo c aenoaeaoeaiei o?ii?/iei aa?oiueiuaeaiiei neioneoii, yeei ?? ia canoiniaoaaee. Iie?auaiiy iiniaiai aeeoaiiy ianoaei o 93,1% i?ioe 75% aac canoinoaaiiy eaiie "A?iio?ii-2", i?e oiio ia 5 aeaiue a?aeiia?aeii o 34,5% oa o 28,6%. Cieeiaiiy aieiaiiai aieth ia 5 aeaiue a?aei?/aee 52,2% oai?eo i?ioe 28,6%, a ia 8 aeaiue any a?oia ianoaaeaieo i?ioe 76,2% oeo, yeei ia canoiniaoaaee eaiio "A?iio?ii-2". Ciaioaiiy e?eueeino? aeae?eaiue c iina ia 5-ee aeaiue eiinoaoiaaii o 40,8% i?ioe 32%, cieeiaiiy aieae a iaeano? i?iaeoe?? aaeii?iaeo iacoo ia 5-ee aeaiue cao?eniaaii o 33,3% oa 28,6% a?aeiia?aeii, ciaioaiiy a?ia?ai?? oa iaa?yeo neeciai? iaieiiee a?aei?/aii a?aeiia?aeii o 39,3% oa 30,7%. Ioaea, ye aeaeii c aeuaneacaiiai, canoinoaaiiy eaiie "A?iio?ii-2", aea? ciiao nei?ioeoe ia 2-3 aei? ia??iae e?eoaaiiy oai?eo. Aeniiaee. 1. A 1981-1985 ?ieao a noaoe?iia?? c 9401 aini?oae?ciaaieo a EI? a?aeae?eaiiy, o 925 ae?aaiinoiaaii o?ii?/i? caiaeuei? i?ioeane i?eiiniaeo iacoo, ui neeaei 9,84% an?o oai?eo, a a 1991-1995??. c 7234 o 878 aai 12,14%, oiaoi a?aenioie oai?eo c o?ii?/ieie caiaeueieie i?ioeanaie i?eiiniaeo iacoo a i?neyaaa??eiee ia??iae c??n ia 2,3 (t=4.68, ?<0.01). 2. Na?eici? oneeaaeiaiiy, yeeie noi?iaiaeaeoaaeiny o?ii?/ia caiaeaiiy aa?oiueiuaeaiii? iacooe o 1981-1985 ?ieao aoee o 0,91% (8 aeiaaee?a ia 883 oai?eo), a 91-95 ??.-3,93% (32 ia 815), oiaoi c?inee o 4,32 ?ace (t=4.01 p<0.01). 3. ?cieueiaaia o?ii?/ia caiaeaiiy aa?oiueiuaeaiii? iacooe a 1981-1985 ?ieao aoei o 26,3% oai?eo, a o 1991-1995 – o 41,35% (t=6.62, p<0.001). A i?neyaaa??eiee ia??iae iai?oeeanue oaiaeaioe?y aei c?inoaiiy aenoaeaoeaieo oi?i o?ii?/iiai caiaeaiiy aa?oiueiuaeaiii? iacooe, ye? o 1981-1985 ?ieao aoee a 330 oai?eo (37,3%), a o 1991-1995??. o 336 (41,2%). I?iaeoeoeai? oi?ie caoai?thaaiiy cono??/aeenue o 553 oai?eo (62,7%) a 1981-1985 ?ieao, ? o 479 (58,8%) a 1991-1995 ??. *anoioa o?ii?/iiai aaeii?eoo ii iioiaeaeaiith noaiiaeea: ?eiiaaii? -55% oa 58%, iaeiioiaaii?-22% oa 23%, ci?oai?–23% oa 19%; 4. Ca ee?i?/iei ia?aa?aii eaaea oi?ia caoai?thaaiiy niinoa??aaeany o 39,6% o 1981-1985 ?ieao oa 35,2% 1991-1995??., na?aaeiuei? aaaeeino? - o 59,5% oa o 60,9% oai?eo o 1991-1995??.. 5. O oai?eo ia o?ii?/iee aa?oiueiuaeaiiee neioneo noai O-nenoaie ?ioi?oaoo oa?aeoa?eco?oueny iiieaeaiiyi caaaeueii? e?eueeino? O-e?ioioeeo?a, oa O-aeoeaieo e?ioioeeo?a ye aei aaa??? ia *AAN oae ? i?ney. I?ney aaa??? oaeiae eiinoaoiaaii cieaeaiiy e?eueeino? O-aaeia??a, O-noi?ani??a ? oee?eoethth/eo ?ioiieo eiiieaen?a. Iieacieee aoii?aeueiiai ?ioi?oaoo o oai?eo ia o?ii?/iee aa?oiueiuaeaiiee neioneo aei aaa??? ia *AAN oa?aeoa?ecothoueny aeinoia??iei cieaeaiiyi a ia?eoa?e/i?e e?ia? e?eueeino? IgA, a a i?neyaaa??eiee cia/iith aeen?ioiiaeiaoe?iai??th ? aeinoia??iei cieaeaiiyi IgG oa IgI A ne?iaaooe? e?ia?. 6. No/ani? ?aioaaiieia?/i? iaoiaee ae?aaiinoeee aeicaieythoue aeyaeoe iacia/i? ci?ie neaiaeo c? noi?iie neeciai? iaieiiee, ae?aaiinooaaoe eaoaioi? oi?ie neioneo?a. ?acii c oei, ioe?iea aeaieo I?O aeiaaa? eaae?o?eiaaiiai, aeeoa?aioe?eiaaiiai i?aeoiaeo. 7. A eiiieaeniiio e?eoaaii? aenoaeaoeaieo oi?i o?ii?/iiai aaeii?eoo ae?aiaaeiee iaoiae canoiniaaiee o 95,6% oai?eo o 1981-1985 ?ieao oa a 98,9% oai?eo o 1991-1995 ??. iiceoeaiee aoaeo o oai?eo aenoaeaoeaiith oi?iith o?ii?/iiai aa?oiueiuaeaiiiai neioneoo aeinyaiooi o 69% oa 77% oai?eo, a?aeiia?aeii o 1981-1985 ?ieao oa 1991-1995??., c ieo o 19% oa 22%- aecaei?iaeaiiy, oa o 50% ? 55% a?aeiia?aeii - iie?auaiiy. 8. Canoinoaaiiy ii?aeiaii? iaoiaeeee aaaaeaiiy e?e?a a iacooo ? ii?iaeieio iina i?e oiiioi?ac? ni?ey? a?aeiiaeaiith aeeoaeueii? ooieoe?? iina, ?icoe?aiith aea?aeieo ioai??a aa?oiueiuaeaiieo iacoo, e?ea?aeo? iaa?ye, iie?iici? ci?ie neeciaeo iaieiiie iina oa neion?a. 9. Ae?aioaaiiy, aeei?enoaiiy ii?aeiaii? iaoiaeeee aaaaeaiiy e?e?a a iacooo ? ii?iaeieio iina i?e oiiioi?ac? oa canoinoaaiiy e?i?eii-iiey?eciaaiiai na?oea eaiie "A?iio?ii-2", aea? ciiao ia 2-3 aei? nei?ioeoe ia??iae oa aeinyaoe e?aui? aoaeoeaiino? e?eoaaiiy aenoaeaoeaieo oi?i o?ii?/iiai neioneoo. I?aeoe/i? ?aeiiaiaeaoe?? 1. Ae?aaiinoeea o?ii?/ieo aa?oiueiuaeaiieo neioneo?a aeiaaa? aea/aiiy ao?iiaoiaaiaoe/ieo i?e/ei eiai aeieeiaiiy, a?aooaaiiy iaaaoeaiiai aieeao caa?oaeiaiiy ciai?oiueiai na?aaeiaeua, aeine?aeaeaiiy ?ioiieia?/ii? ?aaeoeaiino?, canoinoaaiiy no/anieo iaoiae?a i?iiaiaai? ae?aaiinoeee. 2. Eiiieaenia ianoaaeaiiy oai?eo aea? ciiao anoaiiaeoe ee?i?/i? oi?ie caoai?thaaiiy, aecia/eoe i?e/eie neioneoo, aea?aoe a?aeiia?aeio oaeoeeo e?eoaaiiy. 3. A eiiieaeniiio e?eoaaii? aenoaeaoeaieo oi?i o?ii?/iiai aaeii ?eoo, aeioe?eueiei ? ae?aiaaeiee iaoiae, yeee ia? uaaeeeaee oa?aeoa?, aeicaiey? cae?enithaaoe i?noeaaa ao?io?iiia e?eoaaiiy, ni?ey? nei?i/aiith ia??iaeo caoai?thaaiiy, ? i?inoei ? aeinooiiei ia an?o ??aiyo iaaeaiiy niaoe?ae?ciaaii? EI? aeiiiiiae. 4. Aeei?enoaiiy aeinooiieo iaoiaeee oiiioi?aco ei?oeeinoa?i?ae ieie i?aia?aoaie a ii?aeiaii? c aaaaeaiiyi e?e?a o aa?oiueiuaeaiio iacooo ni?ey? a?aeiiaeaiith aeeoaeueii? ooieoe?? iina. 5. Canoinoaaiiy e?i?eii-iiey?eciaaiiai na?oea a eiiieaeniiio e?eoaaiiy aenoaeaoeaieo oi?i aa?oiueiuaeaiieo neioneo?a, ni?ey? ii?iae?caoe?? iaoieia?/ii ci?iaii? neeciai? iaieiiee ii?iaeieie iina, cae??ieth? (noaa?e?co?) ?acoeueoaoe e?eoaaiiy aiane?aeie aieeao ia caaaeueio ?ioiieia?/io ?aaeoeai?noue. Aeey aeinyaiaiiy noaa?e?coth/iai aoaeoo e?eoaaiiy o?ii?/ieo neioneo?a iiaea aooe ?aeiiaiaeiaaia eaiia "A?iio?ii-2", ii?ii?iaiiy yeith i?enei?th? aecaei?iaeaiiy. Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe?? 1. Oeiaa ss. A. Ii??aiyeueiee aiae?c caoai?thaaiiy caiaeueieie i?ioeanaie i?eiiniaeo iacoo ca i’yoe??/iee ia??iae aei- oa i?ney- aaa??? ia *AAN oa ?o o??o?a?/ia e?eoaaiiy //Oe?a?inueeee iaaee/iee a?niee., (1998) O.2.-*enei 1-2 (59-60).-N.112 (VII eiia?an na?oiai? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa. Oaeai?iae, 16-20.08.1998). 2. Oeiaa ss. A. Ii??aiyeueiee aiae?c caoai?thaaiiy ia aaeii?eo ca i’yoe??/iee ia??iae aei- oa i?ney- aaa??? ia *AAN ca aeaieie EI?-ee?i?ee Ee?anueei? iaeanii? ee?i?/ii? e?ea?i? //AEo?i. aooieo, iiniaeo ? ai?eiaeo oai?ia. - 1998. - N 4. C.74-82. 3. Oeiaa ss. A. Caoai?thaai?noue ia o?ii?/iee aaeii?eo ca aeaieie EI?-ee?i?ee Ee?anueei? iaeanii? ee?i?/ii? e?ea?i?. //AEo?i. aooieo, iiniaeo ? ai?eiaeo oai?ia.-1998.-N6.C.69-70. 4. Oeiaass.A. Aiae?c aini?oaeueii? caoai?thaaiino? o?ii?/ieie caiaeueieie i?ioeanaie i?eiiniaeo iacoo ca 1981-1985 oa ca 1991-1995 ?iee ca aeaieie EI?-ee?i?ee Ee?anueei? iaeanii? ee?i?/ii? e?ea?i?. //Aeooaeuei? ieoaiiy i?e?io??o?a?? aooa oa caoai?thaaiue aa?oi?o aeeoaeueieo oeyo?a. Ca??iee iaoa ??ae?a ?anioae?eainueei? iaoeiai-i?aeoe/ii? eiioa?aioe?? “Na?o caoe?a”-aeinyaiaiiy i?e?io??o?a?? a i?aeoeeo ioi?eiiea?eiaieia?a Oe?a?ie”, i?enay/aii? 75-??//th eaoaae?e ioi?eiiea?eiaieia?? EIAII 9-11 aa?aniy 1997 ?. n.95-96. Aiioaoe?? Oeiaa ss.A. Iniaeeaino? ee?i?/iiai ia?aa?ao oa eiiieaenia e?eoaaiiy o?ii?/iiai caiaeaiiy aa?oiueiuaeaiieo iacoo o oai?eo aei oa i?ney aaa??? ia *i?iiaeeuenuee?e aoiii?e aeaeo?inoaioe??.- ?oeiien. Aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.19-ioi?eiiea?eiaieia?y-Ee?anueeee iaoeiai-aeine?ae iee ?inoeooo ioiea?eiaieia?? ?i. i?io. I.N.Eieii?e/aiea, Ee?a, 1999. A aeena?oaoe?? i?eaaaeaii ii??aiyeueiee noaoenoe/iee aiae?c caoai?thaaiino? oa aea/aiiy ia?aa?ao o?ii?/ieo neio?o?a a ianaeaiiy Ee?anueei? iaeano? ca i’yoe??/iee ia??iae aei oa oaeee-aea /an i?ney aaa??? ia *i?iiaeeuenuee?e aoii i?e aeaeo?inoaioe?? a 1986 ?ioe?. I?iaaaeaia ii??aiyeueia ioe?iea /anoioe caoai?thaaiino? ia o?ii?/i? aa?oiueiuaeaii? neioneoe ca ee?i?/ieie, iaoaiaoii?/ieie iciaeaie, ui aea? ciiao i?iaiaeeoe aeeoa?aioe?eiaaia ? eiiieaenia e?eoaaiiy. Ia aaeeeiio ee?i?/iiio iaoa??ae? aeiaaaeaia aeioe?euei?noue ae?aioaaiiy aa?oiueiuaeaiieo iacoo i?e e?eoaaii? aenoaeaoeaieo, ci?oaieo oi?i aa?oiueiuaeaiieo neioneo?a. Aea/aia aoaeoeai?noue eiiieaeniiai iaoiaeo e?eoaaiiy, iniiaiei eiiiiiaioii yeiai ? ae?aioaaiiy aa?oiueiuaeaiieo ia coo ? canoinoaaiiy ao?io?iiieo oa iaoiaaiaoe/ieo cania?a iaoiaeii 2-3 ?aciaiai c?ioaiiy, aaaaeaiiy ?o oeyoii oiiioi?aco. I?iaiae?ciaaii aieea e?i?eii-iiey?eciaaiiai iaeiaa?aioiiai na?oea ia aoaeoeai?noue e?eoaaiiy aeayeeo oi?i o?ii?/ieo aa?oiueiuaeaiieo neioneo?a (eaiie "A?iio?ii-2"), ui i?enei?th? aecaei?iaeaiiy. Eeth/ia? neiaa: o?ii?/i? caiaeuei? i?ioeane i?eiiniaeo iacoo, o?ii?/iee aa?oiueiuaeaiiee neioneo, e?i?eii-iiey?eciaaia na?oei, aaa??y ia *AAN. Oeiaa ss.A. Iniaaiiinoe eeeie/aneiai oa/aiey e eiiieaeniia ea/aiea o?iie/aneiai ainiaeaiey aa?oia/aethnoiuo iacoo o aieueiuo aei e iinea aaa?ee ia *a?iiaueuenueeie aoiiiie yeaeo?inoaioeee.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.19-ioi?eiiea?eiaieiaey.- Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo ioi?eiiea?eiaieiaee ei. i?io. I.N.Eieiiee/aiei, Eeaa, 1999. A aeenna?oaoeee i?eaaaeaii n?aaieoaeueiue noaoenoe/aneee aiaeec caaieaaaaiinoe e eco/aii oa/aiea o?iie/aneeo neioneoia a ianaeaiey Eeaaneie iaeanoe ca iyoeeaoiee ia?eiae aei e oaeie aea iinea aaa?ee ia *a?iiaueueneie aoiiiie yeaeo?inoaioeee a 1986 aiaeo. A 1981-1985 aiaeao a noaoeeiia?a n 9401 ainieoaeece?iaaiiuo a EI? ioaeaeaiea o 925 aeeaaiinoe?iaaii o?iie/aneia ainiaeaiea aa?oia/aethnoiuo iacoo, eioi?ia ninoaaeei 9,84% io anao aieueiuo, a a 1991-1995aa., n 7234 a 878 eee 12,14%, oi anoue i?ioeaio aieueiuo n o?iie/aneei ainiaeaieai aa?oia/aethnoiuo iacoo a iineaaaa?eeiue ia?eiae aic?in ia 2,3% (t=4.68, ?<0.01). I?iaaaeaia n?aaieoaeueiay ioeaiea /anoiou caaieaaaaiinoe o?iie/aneei aa?oia/aethnoiui neioneoii ca eeeie/aneeie, iaoaiaoiie/aneeie i?eciaeaie, /oi aeaao aiciiaeiinoue i?iaiaeeoue aeeooa?aioee?iaaiiia e eiiieaeniia ea/aiea. Na?ueaciua ineiaeiaiey, eioi?uie nii?iaiaeaeaeinue o?iie/aneia ainiaeaiea aa?oia/aethnoiuo iacoo a 1981-1985 aiaeao, auee a 0,91% (8 neo/aaa ia 883 aieueiiai), a a 91-95 aa.-3,93% (32 ia 815), oi anoue aic?inee a 4,32 ?aca (t=4.01 p<0.01). Eciee?iaaiiia o?iie/aneia ainiaeaiea aa?oia/aethnoiuo iacoo a 1981-1985 aiaeao auei a 26,3% aieueiuo, a a 1991-1995 - a 41,35% (t=6.62, p<0. 001). Yenoaeaoeaieua oi?iu o?iie/aneiai ainiaeaiey aa?oia/aethnoiuo iacoo a 1981-1985aa. auee a 330 aieueiiai(37,3%), a a 1991-1995 aa. a 336 (41,2%). I?iaeoeoeaiua oi?iu caaieaaaiey ano?a/aeenue a 553 aieueiiai (62,7%) a 1981-1985 aiaeao, e a 479 (58,8%) a 1991-1995 aa. *anoioa o?iie/aneiai ainiaeaiey aa?oia/aethnoiuo iacoo ii i?ienoiaeaeaieth i?aaenoaaeyea: ?eiiaaiiua -55% e 58%, iaeiioiaaiiua-22% e 23%, niaoaiiua -23% e 19% niioaaonoaaiii a 1981-1985aa. e 1991-1995 aiaeao. Ia aieueoii eeeie/aneii iaoa?eaea aeiaaaeaia oeaeaniia?aciinoue ae?aie?iaaiey aa?oia/aethnoiuo iacoo i?e ea/aiee yennoaeaoeaiuo, niaoaiuo oi?i aa?oia/aethnoiuo neioneoia. Eco/aia yooaeoeaieioue eiiieaeniiai iaoiaea ea/aiey, iniiaiie eiiiiiaio eioi?iai-ae?aie?iaaiea aa?oia/aethnoiuo iacoo e i?eiaiaiea yoeio?iiiuo e iaoiaaiaoe/aneeo n?aaenoa iaoiaeii 2-3 ?aciaiai i?ioaiey, aaaaeaiey eo iooai oiiioi?aca. A eiiieaeniii ea/aiee yenoaeaoeaiuo oi?i o?iie/aneiai aaeii?eoa ae?aiaaeiue iaoiae i?eiaiai a 95,6% aieueiiai a 1981-1985 aiaeao e a 98,9% aieueiiai a 1991-1995 aa. Iieiaeeoaeueiue yooaeo a aieueiuo yennoaeaoeaiie oi?iie o?iie/aneiai aa?oia/aethnoiiai neioneoa aeinoeaioo a 69% e 77% aieueiiai, niioaaonoaaiii a 1981-1985 aiaeao e 1991-1995 aa., a oii /enea a 19% e 22%- aucaei?iaeaiea, e a 50% e 55% niioaaonoaaiii - oeo/oaiea. I?iaiaeece?iaaii aeeyiea eeiaeii-iiey?ece?iaaiiiai iaeiaa?aioiiai naaoa (eaiiu "Aeiio?ii-2"), ia yooaeoeaiinoue ea/aiey iaeioi?uo oi?i o?iie/aneeo aa?oia/aethnoiuo neioneoia, /oi nie?auaao aeeeoaeueiinoue ea/aiey. Ae?aie?iaaiea, eniieueciaaiea iauaaeeiaiiie iaoiaeeee aaaaeaiey iaaeeeaiaioia a iacooo e iieinoue iina i?e oiiioi?aca, i?eiaiaiee eeiaeii-iiey?ece?iaaiiiai naaoa eaiiu "Aeiio?ii-2", aeaao aiciiaeiinoue ia 2-3 aeiy nie?aoeoue ia?eiae ea/aiey e aeinoe/ue eo/oae yooaeoeaiinoe. Eeth/aaua neiaa: o?iie/aneia ainiaeaiea aa?oia/aethnoiuo iacoo, o?iie/aneee neioneo, eeiaeii-iiey?ece?iaaiiue iaeiaa?aioiue naao, aaa?ey ia *AyN. Shkoba Y.V. The peculiarities of clinic development and complex treatment of maxillary sinuses among patient before and after Chernobyl accident. Manuscript. Dissertation for conferring the scientific degree of candidate of medical science in speciality 14.01.19.-diseases of ear, nose and throat. Kyiv Research Institute of Otolaryngology named after Prof. O.S. Kolomiychenko. Kyiv, 1999. The subject of the thesis is the comparative statistical analysis of disease and studying of chronic maxillary sinusitis among the population of Kyiv region during 5 years before and after Chernobyl accident. The aim of this research is to test our hypothesis belonging to differentiation and complex treatment of the disease. The information we posses is very complete. Theories have been built on the experimental data. The method we have planned to use is quite new. It’s the method of draining. The clinic material is focused on the treatment of combined forms of maxillary sinusitis. The influence of linear-polar neocongerentive light of tube ‘’ Bioptron-2’’ on the effective treatment of some forms of chronic maxillary sinusitis was analysed. It has been studied on the basis of applying of ethyotropic and pathogenic means by the method of irrigation 2-3 times a day by introducing a phonophorez. It’s desirable that complex treatment should be used by method of irrigation 2-3 times a day. The objective of the thesis is of great practical significance. Key words: chronic inflammation of maxillary sinuses, chronic maxillary sinusitis, linear-polar neocongerentive light, Chernobyl accident. I?aeienaii aei ae?oeo 21.06.1999. Oi?iao 60o841/16. Iai?? ?1. Ionaoiee ae?oe. Oiia. ae?oe. a?e.1,0. Oe?aae 100aec. Aeaeaaie/ee oeaio? I?aniaiai Aaaionoaa Iiaei 252119, Ee?a, aoe. Iaeueieeiaa 36/1.

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