IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE?INOEOOO A?IO?I?? ?i. I. A.
IAEEAAe?IA

OAOIAIIEAIA AANEE?AIA

OAeE 577. 115.3+577.161.3+577.352.333

INIAEEAINO? O?C?IEIA?*II? OA IAIA?AIIO?IIII? Ae?? A?IEIA?*II AEOEAIIAI
EIIIEAENO OINOIE?I?Ae?A C A?Ae?IA?IIO?A

03.00. 04 – A?io?i?y

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
a?ieia?/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie.

Iaoeiaee ea??aiee – aeieoi? a?ieia?/ieo iaoe, /eai-ei?. IAI Oe?a?ie

Aeii/aiei Aai?a?e A?eoi?iae/,

?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie,

caa?aeoaa/ a?aeae?eo a?io?i?? eioa?iaio?a.

Io?oe?ei? iiiiaioe: aeieoi? a?ieia?/ieo iaoe, no.iaoe.ni?a?.

Iaeeoaaa Ia?aa?eoa Einoyioei?aia,

?inoeooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie,caa?aeoaa/
a?aeae?eo iae?io?i??;

eaiaeeaeao a?ieia?/ieo iaoe

Ee?iaoaanueeee A?oae?e Ia?’yiiae/,

?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie,

no. iaoe. ni?a?. a?aeae?eo a?io?i?? e?i?ae?a.

I?ia?aeia onoaiiaa – Ee?anueeee oi?aa?neoao ?i. Oa?ana Oaa/aiea,
eaoaae?a a?io?i??.

Caoeno a?aeaoaeaoueny “22” ethoiai 1999 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.240.01 a ?inoeooo? a?io?i?? ?i.
I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe. Eaiioiae/a, 9).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
a?io?i???i. I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe.
Eaiioiae/a, 9).

Aaoi?aoa?ao ?ic?neaiee “21” n?/iy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao a?ieia?/ieo iaoe
E??NAIEI I.A.

15

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca inoaii? ?iee oaaaa aeine?aeiee?a caa?iaia aei
ieoaiiy canoinoaaiiy oinoie?i?ae?a oa iie?iaiane/aieo aee?ieo eeneio, ye
e?eoaaeueieo i?aia?ao?a oe?ieiai niaeo?o a?ieia?/ii? ae??, ui
aeyaeythoue aoaeo i?e ??cieo ?ioieneeaoe?yo o ia/?ioe?, aiaeie?eiieo
?iceaaeao oa na?oeaai-noaeeiieo caoai?thaaiiyo [Patel J.M., 1993].

Inoaii?i /anii c?iaeaii aaeeeee e?ie o ?icoeo?oaaii? cia/aiiy e?i?aeieo
eiiiiiaio?a iaia?ai, ye? aeeiiothoue ia eeoa no?oeoo?io ?ieue, aea e
aa?ooue o/anoue o eeth/iaeo i?ioeanao ia?aaea/? ?aaoeyoi?ieo neaiae?a,
?aaoeyoe?? aeoeaiino? iaia?aiica’ycaieo oa?iaio?a. Aaeaioiaaiiee
oa?aeoa? i?e aeno?aiaeueieo neooaoe?yo oa iaoieia?/ieo noaiao ia? ci?ia
??aiy oinoie?i?ae?a, ui iia’ycai? ?c ci?iaie i?ioeano ?o neioaco oa
iai?io ?a/iaei. Oinoie?i?aee, ye iiaa?oiaai-aeoeai? ?a/iaeie,
a?ae?a?athoue aaaeeeao ?ieue o caaacia/aii? ?ani??aoi?ii? ooieoe?? oa
caoeno? eaaaiue a?ae eiioaeoo c ??cieie i?e?i/anoeaie oa c
i?e?ii?aai?ciaie [Aa?aieiae/ A.I., 1983]. A?ieia?/i? iaia?aie oeaiei c
??ciith ooieoe??th iathoue o nai?io neeaae? oinoie?i?aee c iaaieie
aa??aioaie aee?iieeneioieo caeeoe?a. A?ae aee?iieeneioiiai neeaaeo
oinoie?i?ae?a caeaaeeoue ?o iaoaaie?/ia aeoeai?noue, a oaeiae
u?euei?noue aai ??aeeii?noue iaia?ai [I?aaaeeia E.I., 1975]. Ia a?aei?io
a?ae nnaaoe?a e?i?aee ii?nueeeo i?aai?ci?a aaaao? iie??iiaeie aee?ieie
eeneioaie, iniaeeai iiaaa — iaiane/aieie aeeicaiaioa?iiaith oa
aeieicaaaena?iiaith eeneioaie [Metzman M.S., 1978]. Ieoaiiy i?i
a?ieia?/i? aeanoeaino?, niaoeeo?/io o?c?ieia?/io aeoeai?noue
oinoie?i?ae?a c ii?nueeeo i?aai?ci?a oa iaoai?ci iai?io a iaia?aiao
ee?oei ia aeinoaoiuei c’yniaaii. ??ciiiai?oiee aee?iieeneioiee neeaae
oinoie?i?ae?a iaoiiaeth? ?nioaaiiy ??cieo ioe?a oinoie?i?ae?a iaeiiai
aeaeo, ui ni?e/eiy? aeeiiaiiy ieie ??cieo ooieoe?e -– a?ae no?oeoo?ieo
oa aioeieneaeaioieo aei ooieoe?e ?aaoeyoe?? aeoeaiino? oa?iaio?a,
o?ainii?oo, ia?aaea/? neaiae?a, — an?o i?ioean?a, ye? ia?aa?aathoue ia
??ai? iaia?ai. Oiio aea/aiiy a?ieia?/ieo aeanoeainoae, niaoeeo?/ii?
o?c?ieia?/ii? ae?? oinoie?i?ae?a c ii?nueeeo i?aai?ci?a oa ?o
?aaoeyoi?ii? ?ie? a iaia?aiao oeaiei i?aai?cio aecia/a? aeooaeuei?noue
?iaioe o oeueiio iai?yieo.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. I?iaaaeai?
aeine?aeaeaiiy ? i?aai?/iith neeaaeiaith /anoeiith iaoeiaiai iai?yieo
?iaioe eaai?aoi??? oaoiieia?? a?ii?aia?ao?a a?aeae?eo eioa?iaio?a
?inoeoooo a?io?i?? ?i.I.A. Iaeeaae?ia IAI Oe?a?ie. Ie?ai? ?icae?ee
?iaioe aeeiioaaeenue ca?aeii c ieaiaie iaoeiai-aeine?aeieo ?ia?o ii
oaiao: “?ic?iaea oaoiieia?? iaea?aeaiiy ?c ii?nueeeo i?aai?ci?a
o?c?ieia?/ii aeoeaieo niieoe niaoeeo?/ii? ae?? aeey iio?aa iaaeeoeeie”
(IAe? ? aea?aeaaiiai ?a?no?o EA 01007145 ?.), “Aea/aiiy aca?iica’yceo
i?e?iaeieo aioeieneaeaio?a oa oinoie?i?ae?a a ?aaoeyoe??
no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ee?oei c ??ciith ooieoe??th”
oa iaoeiai-aeine?aeieo ?ia?o, ye? iaea?aeaee i?ei?eoaoia o?iainoaaiiy ca
i?aenoieaie ?anioae?eainueeeo eiieo?n?a: “?ic?iaea iiaiai caniao ia
iniia? oinoie?i?ae?a c ii?nueeeo i?aai?ci?a, ui ia?
iaia?aiinoaa?e?coth/?, aioeieneaeaioi? ? no?oaeoaioi? aeanoeaino?,
aieeaath/iai ia iai?ii? oa ?aia?aoeaiee i?ioeane”, “?aaoeyoi?iee
iaoai?ci iai?io oinoie?i?ae?a o iaia?aiao ee?oei ia/?iee ? eaaaiue oa
?ieue i?e?iaeieo aioeieneaeaio?a a ?aaoeyoe?? no?oeoo?ii? ?
ooieoe?iiaeueii? i?aai?caoe?? iaia?ai”, “Ooieoe?iiaeuei? ci?ie
?ai?iaeoeoeaieo oa aeeoaeueieo i?aai?a oaa?ei i?ae aieeaii iaeeo aeic
?aae?aoe?? oa ?ic?iaea iiaeo aoaeoeaieo cania?a a?aeiiaeaiiy ci?iaieo
ooieoe?e ca aeiiiiiaith niaoeeo?/ieo a?i?aae?ii?ioaeoi??a c iiethne?a”.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei aea/aiiy o?i?/iiai
neeaaeo, niaoeeo?/ii? o?c?ieia?/ii? aeoeaiino?, a?ieia?/ieo aeanoeainoae
eiiieaeno “ii?nueeeo” oinoie?i?ae?a, ui aoee aeae?eai? c iiethne?a, oa
aea/aiiy ?o iai?io o iaia?aiao ee?oei aeey noai?aiiy i?e?iaeiiai
aoaeoeaiiai i?io?eaeoe/iiai oa e?eoaaeueiiai caniao e?i?aeii? i?e?iaee c
a?ae?ia?iio?a.

A?iia?aeii aei iniiaii? iaoe a ?iaio? ae??ooaaeenue ianooii? caaaeaiiy:

1. Aea/eoe o?i?/iee neeaae i?e?iaeiiai eiiieaeno oinoie?i?ae?a,
io?eiaiiai c aiiaae aieiaiiiaeo iiethne?a, oa aecia/eoe e?euee?niee oa
ye?niee ai?no oinoie?i?ae?a, aee?ieo eeneio ? ai?iieeneio.

2. Aeine?aeeoe a?ieia?/i? aeanoeaino? oa niaoeeo?/io o?c?ieia?/io ae?th
a?ii?aia?aoo, noai?aiiai ia iniia? eiiieaeno “ii?nueeeo“ oinoie?i?ae?a.

3. Aea/eoe aioeieneaeaioi? aeanoeaino? eiiieaeno oinoie?i?ae?a in vitro
oa in vivo oa eiai aieea ia nenoaio aioeieneaeaioiiai caoenoo i?aai?cio.

4. Aeine?aeeoe ?ieue “ii?nueeeo” oinoie?i?ae?a o iiaeoeyoe??
no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ee?oei oaa?ei.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aoei aea/aii /?i?/iee
neeaae eiiieaeno oinoie?i?ae?a c aiiaae aieiaiiiaeo iiethne?a ?
iieacaii, ui ?o aieiaia a?aei?ii?noue a?ae oinoie?i?ae?a nnaaoe?a
iieyaa? a iniaeeainoyo aee?iieeneioiiai neeaaeo. Ia iniia? “ii?nueeeo”
oinoie?i?ae?a aia?oa noai?aii oa ioa?aeoa?eciaaii iiaee aoaeoeaiee,
i?e?iaeiee, e?eoaaeueii-i?io?eaeoe/iee can?a — a?ii?aia?ao “Eaeueiio?e”,
anoaiiaeaii eiai no?oaeoaioio, aioeieneaeaioio oa iaia?aiinoaa?e?coth/o
ae?th. Aeyaeaii, ui iaia?aiio?iiia ae?y oinoie?i?ae?a c a?ae?ia?iio?a
iia’ycaia c ?aaoeyoe??th no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ? ui
aeaiee oinoie?i?aeiee eiiieaen ia? oe?ieee niaeo? o?c?ieia?/ii? oa
oa?iaeieia?/ii? aeoeaiino?.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aacoth/enue ia iaaaaeaieo
aenia?eiaioaeueieo aeaieo, aeyaeaii, ui aeine?aeaeoaaiee i?aia?ao
“Eaeueiio?e” ? aoaeoeaiei o e?eoaaii? ?yaeo aenia?eiaioaeueieo
iaoieia?e: a?i caiia?aa? ?icaeoeo iaa?yeo eaaaiue, ei?eao?
iaaeinoaoi?noue no?oaeoaioo oa iie?ioo? noai

ia/?iee i?e oiene/iiio aaiaoeo?. Iieacaii eiai aioeieneaeaioi?
aeanoeaino?, caeaoi?noue aieeaaoe ia aeoeai?noue aioeieneaeaioieo
oa?iaio?a o oeaieiao c ??ciith ooieoe??th, ii?iae?coaaoe oinoie?i?aeiee
neeaae i?e?iniiaeueieo iaia?ai, ci?ithaaoe neeaae aee?ieo eeneio
iaia?aiieo oinoie?i?ae?a. Cai?iiiiiaaii canoinoaaiiy i?aia?aoo c
“ii?nueeeo” oinoie?i?ae?a aeey e?eoaaiiy oa i?io?eaeoeee oai?ia, ye?
noi?iaiaeaeothoueny ieenethaaeueiei no?anii.

Iaea?aeaii «Iaoiaeeeo aea?aeaaieo aei?iaoaaiue” oa “Ianoaiiao” aeey
canoinoaaiiy i?aia?aoo o aaoa?eia??? i?ae iacaith “Ii?ao?e”.

Aeey ?ic?iaee iaaee/iiai caniao “Eaeueiio?e” neeaaeaii aeieoiaioe
aeiee?i?/ieo aei?iaoaaiue aeey i?aaenoaaeaiiy o oa?iaeieia?/iee eii?oao
IIC Oe?a?ie.

Iniaenoee aianie caeiaoaa/ee iieyaa? o aeeiiaii? aenia?eiaioaeueii?
/anoeie ?iaioe, i?aeai?? oa ia?iaoe? e?oa?aoo?ieo aeaieo. Aiae?c oa
iaaiai?aiiy i?iaaaeaii ni?eueii c iaoeiaei ea??aieeii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ? iaaiai?thaaeenue ia can?aeaiiyo a?aeae?eo a?io?i??
eioa?iaio?a, iaoeiaeo nai?ia?ao ?inoeoooo a?io?i?? ?i I.A. Iaeeaae?ia
IAI Oe?a?ie, V I?aeia?iaei?e eiioa?aioe?? “Aeiaioeieneaeaio”.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe iioae?eiaaii 3 noaoo?
oa 1 oace aeiiia?ae?.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iieno iaoa??ae?a oa iaoiae?a aeine?aeaeaiue, ?acoeueoao?a oa
?o iaaiai?aiiy, aeniiae?a ? nieneo e?oa?aoo?e c 292 iaeiaioaaiue. ?iaioa
aeeeaaeaia ia 120 noi??ieao iniiaiiai oaenoo, ?ethno?iaaia 5 ?enoieaie ?
17 oaaeeoeyie.

IAOA??AEE OA IAOIAeE AeINE?AeAEAIUe.

Oinoie?i?aeiee eiiieaen ?c aieiaiiiaeo iiethne?a io?eioaaee ca iaoiaeii
Aeaoeaiei C.I. oa ?i. (Aao. Na?ae 1175486 NNN? A 61E 37/22).

Aenia?eiaioe i?iaiaeeeeny ia uo?ao-naioeyo e?i?? A?noa? aaaith 120-150
a, ye? ia?aaoaaee ia noaiaea?oiiio ?aoe?ii? aiae?ae? oa ia
A-aa?oai?iici?e ae??o?. Ia’?eoii aeine?aeaeaiue neoaeeea ia/?iea oa
eaaai?.

Aenia?eiaioaeueiee A-a?iia?oai?iic o uo??a iiaeaethaaee, oo?eioth/e ?o c
/ioe?eoeaeiaaiai a?eo ia iai?aooo/i?e ae??o? aac a?oai?io A i?ioyaii 4
i?nyoe?a ca iaoiaeii A.A. Nie?e/aaa oa ?i. (1979). Aeey ei?aeoe??
A-a?iia?oai?iiciiai noaio uo??a iaei?e a?oi? aaiaeeee ia?i?aeueii ii 2
ia a?oai?io A o aeaeyae? ie?eiiai ?ic/eio ia 100 a iane o?ea oaa?eie ia
aeiao i?ioyaii aeaio oeaei?a, ?io?e a?oi? – i?ioyaii oaeiai ae /ano
aioo??oiueii/a?aaeiii aaiaeeee “Eaeueiio?e” ii 50 ia ia 100 a iane o?ea
ia aeiao o aeaeyae? aioeuen?? o o?c?ieia?/iiio ?ic/ei?, i?iaeiaaeoth/e
oo?eioaaoe uo??a ia A-aa?oai?iici?e ae??o?.

?ioieneeaoe?th CCl 4 o uo??a iiaeaethaaee:

1) aeey aeine?aeo c o?ii?/iei NNl4-?iaeoeiaaiei aaiaoeoii — oeyoii
aioo??oiueii’ycaaiai aaaaeaiiy 50% ie?eiiai ?ic/eio NNl4 c ?ic?aooieo
0,4 ie/100 a iane oaa?eie (EAe50) i?ioyaii 4 ae?a. Ei?eaoth/ee aieea
“Eaeueiio?eo” aea/aee i?e eiai aioo??oiueii/a?aaeiiiio aaaaeaii? 10
ia/100 a iane o?ea oaa?eie ii/eiath/e c 4 aei 12 aeiae;

2) aeey aeine?aeo c aino?ei NNl4-?iaeoeiaaiei aaiaoeoii — oeyoii
iaeii?aciaiai aioo??oiueii/a?aaeiiiai aaaaeaiiy 50% ie?eiiai ?ic/eio
NNl4 c ?ic?aooieo 0,2 ie/100 a iane oaa?eie (EAe25), ?io?e a?oi?
iaeii/anii c NNl4 aaiaeeee o oaeee aea niin?a ii 50 ia 50% ie?eiiai
?ic/eio “Eaeueiio?eo” ia 100 a iane o?ea. Eiio?ieuei?e a?oi? oaa?ei
aaiaeeee oaeee aea ia’?i ie??.

E?i?aei? aeno?aeoe io?eioaaee ca iaoiaeii L.Folch et al. (1957).
Oieanoa?ei aecia/aee ca iaoiaeii E.E.?icaioeaaeaa (1962), ai?no
oinoie?i?ae?a o e?i?aeieo aeno?aeoao ca iaoiaeii P.S.Chen (1956), ai?no
?iaeea?aeoaeueieo oinoie?i?ae?a aecia/aee ca e?euee?noth iai?aai?/iiai
oinoi?o ca aeiiiiiaith iie?aaeaoiiai ?aaaaioo ca iaoiaeii V.E. Vaskovsky
(1975), ai?no aoaeaaiae?a ca iaoiaeii R.J.Dimler (1952), ai?no
caaaeueiiai acioo ca iaoiaeii Ae.E.Oa?aeiaia (1957).

O?iiaoia?ao?/ia ?icae?eaiiy ?iaeea?aeoaeueieo oinoie?i?ae?a i?iaiaeeee
ca iaoiaeii aeaiaei??ii? oiieioa?iai? o?iiaoia?ao?? ia ieao?aeao c
nee?eaaaeai ENE-2 oa ieao?aeao Sorbfil (N?N?). I?e ?icaiioe? o ia?oiio
iai?yieo aeei?enoiaoaaee nenoaio oei?ioi?i:iaoaiie:aaicie:28% ai?ae
(65:30:10:6-8), a a ae?oaiio —
oei?ioi?i:iaoaiie:aaicie:aoeaoii:eueiaeiaa ioeoiaa eeneioa
(70:30:10:5:4:1) (V.I. Svetashev; V.E. Vaskovsky, 1972).

?aeaioeo?eaoe?th oinoie?i?ae?a i?iaiaeeee ca aeiiiiiaith niaoeeo?/ieo
?aaeoe?e ia ?o ooieoe?iiaeuei? a?oie (I. Eaeon, 1975; V.E. Vaskovsky,
N.A. Latyshev, 1975; C.M. van Gert et al., 1973).

Ai?no aee?ieo eeneio aecia/aee o?iiaoia?ao?/iei iaoiaeii ca aeiiiiiaith
aaci-??aeeiiiai o?iiaoia?aoa “Carlo Erba” (Italy) c iiia?aaei?i
iaoeethaaiiyi c?ace?a (J.P. Carreau, J.P.Dubaco, 1978). Aeey
e?euee?niiai aiae?co iaoeeiaeo ao???a aee?ieo eeneio aeei?enoiaoaaee
iaaeai? eieiiee ?ici??ii 3,5i o 3 ii. sse iin?e canoiniaoaaee Chromatron
NAW-DMSC ?c 7,5% iaianaiith oacith Silar-5 N? (Serva, Aa?iai?y).
A?aenioeiaee ai?no aee?ieo eeneio a aeno?aeo? ?ic?aoiaoaaee ca ieiuath
i?e?a.

Iiaa?oiaaee iaoya aecia/aee ca iaoiaeii aoyaiooi? neee ieanoeiee ca
aeiiiiiaith aa?oeeaeueieo oa?ac?a A?eueaaeueia ca iaoiaeii A.A Ae?eoi
(1981).

No?oaeoaioe eaaaiue e?ie?a oa uo??a iaea?aeoaaee ca iaoiaeii R.H. Notter
et al. (1983). I?e?iniie oeaiei uo??a aeae?eyee ca iaoiaeii J.B.
Shenkman et al. (1974). Ai?no caaaeueiiai a?eeo aecia/aee ca iaoiaeii
O.H. Lowry, et al. (1951). Noia?ieneaeaeeniooacio o?aeoe?th io?eioaaee
ia iniia? iaoiae?a J.M. Cord, I. Fridovich et al. (1969), B.B. Keele et
al. (1971) o iiaeeo?eaoe?? aeey i?e?inii.

Aecia/aiiy aeoeaiino? noia?ieneaeaeeniooace (NIAe) i?e?inii i?iaiaeeee
ca iaoiaeii Marklund S. at al. (1974). Aeoeai?noue eaoaeace aecia/aee ca
iaoiaeii I.A. Ei?iethe oa ?io. (1988). ?ioaineai?noue ia?aeeniiai
ieeneaiiy e?i?ae?a (IIE) aea/aee ii iaeiie/aiith iaeiiiaiai
ae?aeueaeaa?aeo (IAeA) ca iaoiaeaie TH.A. Aeaaeeie?iaa oa ?io. (1972),
?.Ae. Noaeueiie (1977), oa ii ooai?aiith ae??iiaeo eii’thaao?a (AeE) ca
iaoiaeii TH.A. Aeaaeeie?iaa oa ?io. (1972) oa E.?. Aeyoaaie oa ?io.
(1991).

?acoeueoaoe aeine?ae?a ia?iaeai? noaoenoe/ii c aeei?enoaiiyi t-e?eoa??y
No’thaeaioa ii E.A.Ieaeio (1960). A??ia?aeieie aaaaeaee ?acoeueoaoe i?e
p0,05.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss.

1. Aea/aiiy o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno c aiiaae
iiethne?a

Oaaeeoey 1.1.

O?i?/iee neeaae oinoie?i?aeiiai eiiieaeno, aeae?eaiiai c aiiaae
aieiaiiiaeo iiethne?a.

?a/iaeie% a?ae caaaeueii? e?eueeino?Oinoie?i?aee75,0 — 85,0Caaaeueiee
oieanoa?ei2,0 — 5,0A?euei? aee?i? eeneioe0,1 — 2,8Aoaeaaiaee0,1 —
0,3Iaioeaee0,1 — 0,5A?eie-?iaeea?aeoaeuei? oinoie?i?aee
:Oinoaoeaeeeoie?i72,0 — 87,0Oinoaoeaeeeaoaiieai?i7,0 —
12,0No?iaii??e?i7,0 — 9,0Aeeoinoaoeaeeeae?oea?ei0,4 —
0,8Oinoaoeaeee?iiceoie1,5 — 2,2Oinoaoeaeeena?ei0,6 — 1,2I?ei?oea. O
oaaeeoe? iaaaaeaii ocaaaeueiai? aeai? o?i?/iiai neeaaeo oinoie?i?aeieo
eiiieaen?a c a?ae?ia?iio?a, ui aoee io?eiai? c ??cii? ne?iaeie.

?acoeueoaoe aeine?aeaeaiue o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno,
io?eiaiiai ?c aiiaae aieiaiiiaeo iiethne?a, na?ae/aoue, ui aei eiai
neeaaeo aoiaeeoue aei 80% oinoie?i?ae?a, iacia/ia e?euee?noue
oieanoa?eio, a?eueieo aee?ieo eeneio, aoaeaaiae?a, ai?iieeneio,
iaioeae?a oa ne?aeia? caeeoee a?oai?io A (oaae.1.1).

Na?aae oinoie?i?ae?a 70% noaiiaeoue oinoaoeaeeeoie?i oa o cia/ii iaio?e
e?eueeino? oinoaoeaeeeaoaiieai?i, no?iaii??e?i, oinoaoeaeee?iiceoie,
oinoaoeaeeena?ei, oinoaoeaeeeaeeae?oea?ei.

I?e ii??aiyeueiiio aeine?aeaeaii? oinoie?i?aeiiai eiiieaeno, io?eiaiiai
c a?ae?ia?iio?a, oinoie?i?ae?a eo?y/eo y?oeue oa ??cieo oeaiei nnaaoe?a,
aeyaeaii, ui “ii?nuee?” oinoie?i?aee e??i iniiaieo aee?ieo eeneio, ye?
oa?aeoa?i? aeey an?o oaa?ei, oiaoi iaeuei?oeiiai? (N 16:0), noaa?eiiai?
(N 18:0), iea?iiai? (N 18:1), i?noyoue oae? aeeoo?ai iaiao?aei? eeneioe,
ye e?iieaiiaa (N 18:3) oa cia/io e?euee?noue a?ieia?/ii aeoeaieo aee?ieo
eeneio- a?ao?aeiiiao (N 20:4), aeeicaiaioa?iiao (N 20:5),
aeieicaaaena?iiao (N 22:6), ye? o neeaae? oinoie?i?ae?a ?ioiai
iioiaeaeaiiy i?noyoueny o ne?aeiaeo e?eueeinoyo, aai cian?i a?aenooi?
(oaae.1.2).

Oaaeeoey 1.2

A?aenioeiaa ni?aa?aeiioaiiy iaoeeiaeo ao???a aee?ieo eeneio o neeaae?
oinoie?i?ae?a ?c ??cieo aeaea?ae.

AEe?i? eeneioeAiiaaee eaeueia?asseoey eo?y/?Na?oea
oaa?eiIa/?ieaoaa?eiIicie oaa?eiN 16 : 048,433,922,713,429,8N 16 :
10,71,0—1,1N 18 : 06,510,55,722,314,1N 18 : 19,831,114,511,330,3N 18 :
20,517,739,814,59,2N 18 : 310,6—-N 20 : 0——N 20 : 1——N 20 :
2——N 20 : 3—3,56,3-N 20 : 41,53,17,615,76,1N 20 : 54,5—-N 22 :
00,9—-N 22 : 53,0—-N 22 : 612,3—4,02,6I?eei?oea. Aeai? neeaaeo AEE
c eo?y/eo y?oeue, oeaiei na?oey, ia/?iee oa iiceo oaa?ei acyo? c
e?oa?aoo?e (E.Ae.Aa?aaeuenii; “Avanti” Polar Lipids,1995).

2. No?oaeoaioii-iiae?ai? aeanoeaino? oinoie?i?aeiiai eiiieaeno ?c aiiaae
eaeueia??a

Aeyaeaii iiae?ai?noue o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno ?c
aiiaae iiethne?a ? no?oaeoaio?a eaaaiue nnaaoe?a, o yeiio oinoie?i?aee
oaeiae neeaaeathoue aei 80% ii?yae c iacia/iith e?euee?noth oieanoa?eio,
a?eueieo aee?ieo eeneio, aoaeaaiae?a, iaioeae?a. Na?aae oinoie?i?ae?a o
iaio aeiaaeeao ia?aaaaea? oinoaoeaeeeoie?i (oaae.2.1).

I?e aea/aii? a?ieia?/ieo aeanoeainoae “ii?nueeeo” oinoie?i?ae?a
aeyaeaii, ui eiiieaen, aeae?eaiee c aiiaae aieiaiiiaeo iiethne?a,
i?iyaey? iiaa?oiaao aeoeai?noue, ye ? no?oaeoaio eaaaiue oaa?ei.
I?i?iaeueiee iiaa?oiaaee iaoya i?aia?aoo oa no?oaeoaioa uo?a noaiiaea
11,70,8 oa 10,30,6 a?aeiia?aeii, a iaeneiaeueiee — 46,50,8 oa 42,30,2.

Oaaeeoey 2.1.

O?i?/iee neeaae oinoie?i?aeiiai eiiieaeno ?c aiiaae aieiaiiiaeo
iiethne?a ? no?oaeoaio?a c eaaaiue nnaaoe?a (% a?ae caaaeueii?
e?eueeino?).

?a/iaeiaAiiaaee eaeueia?a (“Eaeueiio?e”)No?oaeoaioe eaaaiue
nnaaoe?aCaaaeueiee oieanoa?ei2,0-5,00-8,0A?euei? aee?i?
eeneioe0,1-2,81,0-27,7Aoaeaaiaee0,1-0,30,1-2,0Iaioeaee0,1-0,51,0-3,0Oino
ie?i?aee
:75,0-85,068,6-90,7Oinoaoeaeeeoie?i72,0-87,058,4-85,0Oinoaoeaeeeaoaiieai
?i7,0-12,03,5-2,6No?iaii??e?i7,0-9,03,2-12,1Aeeoinoiae?oea?eae0,4-0,80,1
-12,0Oinoaoeaeee?iic?oie1,5-2,21,2-6,6Oinoaoeaeeena?ei0,6-1,21,0-6,4I?ei
?oea.O oaaeeoe? iaaaaeaii ocaaaeueiai? aeai? o?i?/iiai neeaaeo
no?oaeoaio?a eaaaiue ??cieo oaa?ei.

I?e ?iaaeyoe?eiiio canoinoaaii? i?aia?aoo “Eaeueiio?e” ia iniia?
“ii?nueeeo” oinoie?i?ae?a c iiethne?a i?e ?ioieneeaoe?? oaa?ei ai?aeii,
aaiceiii, iai?ioaiii aeyaeaii iiceoeaiee aieea ia caaaeueiee noai oaa?ei
oa ia ?o aeaeeaaiiy, a oaeiae, cie?aia, ia ii?iae?caoe?th ii?ooaieo
ooieoe?e eaaaiue, — cieaeaiiy ?ioaineaiino? i?ioeano i?iiooai?aiiy,
ii?iae?caoe?th ee?oeiii? ?aaeoe?? no?oaeoaioo eaaaiue, iieaaoaiiy oiaeo
oiene/iiai i?ioeano, ye iieacaii o oaae.2.2., ui na?ae/eoue i?i
no?oaeoaioiiiiae?ai? aeanoeaino? i?aia?aoo.

Oaaeeoey 2.2.

Noai iiaa?oiaai-aeoeaieo aeanoeainoae eaaaiue aeine?aeaeoaaieo oaa?ei.

?ioieneea-oe?yEiio?ieueNa?aaeiy eaoaeueia eiioeaio?aoe?y
?a/iaeieNa?aaeiy eaoaeueia eiioeaio?aoe?y + “Eaeueiio?e”Iia. iaoya *10-3
i/iIae?ioa-ae o 10-3 ieIia. iaoya *10-3 i/iIae?ioaae o 10-3 ieIia.
iaoya*10-3 i/iIae?ioaae o 10-3
ieIi?ia15,20±0,640,1±0,3Iai?ioai—7,8±1,754,9±0,714,7±0,542,2±2,7Ai?ae—
6,4±0,951,3±1,613,8±0,642,0±0,9Aaicei—8,20±1,0249,9±0,515,8±0,347,6±0,8

3. Aioeieneaeaioi? aeanoeaino? “ii?nueeeo” oinoie?i?ae?a

I?e aeine?aeaeaii? aioeieneaeaioieo aeanoeainoae i?aia?aoo “Eaeueiio?e”
o ii??aiyii? ?c caaaeueiia?aeiiei aioeieneaeaioii a?oai?iii A o
aeine?aeao in vitro aeyaeaia aeicicaeaaeia caeaoi?noue i?aia?aoo
aaeueioaaoe IIE (oaae.3.1).

Oaaeeoey 3.1

Iaeiie/aiiy IAeA o aiiiaaiao? ia/?iee uo??a a i?ioean? niiioaiiiai IIE
i?e aeiaeaaaii? ie?aii a?oai?io A oa i?aia?aoo “Eaeueiio?e” a aeine?aeao
in vitro (n=7, M±m).

Aeica i?aia?ao?a o i?ia? (iea/ca 60 oa.)Ai?no IAeA (iiieue/ia
a?eea)Aaeueioaaiiy IIE i?aia?aoaie (%).A?oai?i A“Eaeueiio?e”A?oai?i
A“Eaeueiio?e”Eiio?ieue0,47±0,15030,45±0,010,47±0,021050,45±0,010,47±0,01
10200,42±0,050,44±0,1272300,40±0,060,44±0,14103400,37±0,030,43±0,4020450
0,27±0,010,44±0,094041000,24±0,010,38±0,0150202000,14±0,020,33±0,0270305
000,04±0,01*0,21±0,06924510000,04±0,02*0,16±0,03*9265I?ei?oea. * —
a?aei?iiino?, a??ia?aei? o ii??aiyii? c eiio?ieai (?<0,05). Aioeieneaeaioi?e ae?? 100 iea a?oai?io A, oiaoi i?eai?/aiith IIE ia 50%, a?aeiia?aea? e?euee?noue i?aia?aoo, ui aei??aith? 500 iea. I?e i?aeaeuaii? iieaciee?a ieenethaaeueiiai no?ano, IAeA oa AeE, o iaia?aiao i?e?inii ia/?iee oa eaaaiue uo??a c iaoieia??th, iaoiiaeaiith iaaeinoa/ath i?e?iaeiiai aioeieneaeaioa a?oai?ia A (aenia?eiaioaeueiiai A–a?iia?oai?iico), aeyaeaii caeaoi?noue “Eaeueiio?eo” ii?iae?coaaoe oe? iieacieee (oaae.3.2). I?e/iio aeyaeaii, ui a iaia?aiao i?e?inii ia/?iee ca A-a?iia?oai?iico ?ioaineai?noue i?ioean?a IIE ca?eueoo?oueny cia/ii a?eueoa, i?ae o iaia?aiao i?e?inii oeaieie eaaaiue, oa anoaiiaeaii a?eueo ae?aaeaiee aieea oinoie?i?aeiiai eiiieaeno c a?ae?ia?iio?a ia cieaeaiiy ieenethaaeueiiai no?ano, iaoiiaeaiiai iaaeinoa/ath i?e?iaeiiai aioeieneaeaioo, a?oai?io A, o iaia?aiao i?e?inii ia/?iee uo??a. Oaaeeoey 3.2 Iaeiie/aiiy i?iaeoeo?a IIE o i?e?iniiaeueieo o?aeoe?yo eaaaiue oa ia/?iee uo??a i?e aenia?eiaioaeueiiio A-a?iia?oai?iic? oa i?e aaaaeaii? a?oai?io A ? i?aia?aoo “Eaeueiio?e” o aeine?aeao in vivo (n=7, M±m). Oiiae aeine?aeoE?euee?noue IAeA (ieiieue/ia a?eea)E?euee?noue AeE (ieiieue/ia a?eea)I?e?iniie eaaaiueIi?ia0,33±0,016,00±0,27A-a?iia?oai?iic0,58±0,06*7,64±0,32*A-a?iia ?oai?iic+a?oai?i A0,46±0,02*5,67±0,50**A-a?iia?oai?iic+“Eaeueiio?e”0,43±0,02***4,97±0,60* **I?e?iniie ia/?ieeIi?ia1,80±0,022,50±0,31*A-a?iia?oai?iic3,90±0,64**11,06±0,13A-a?i ia?oai?iic+a?oai?i A0,61±0,11***8,80±0,30***A-a?iia?oai?iic+“Eaeueiio?e”0,35±0,01**5,39±0,5 1**I?ei?oee.*- a?aei?iiino? a??ia?aei? o ii??aiyii? c iieacieeaie, oa?aeoa?ieie aeey ii?iaeueii? a?oie (?<0,05); **- aeey ii?iaeueii? a?oie ? a?oie c A-a?iia?oai?iicii (?<0,05); ***- aeey a?oie c A-a?iia?oai?iicii (?<0,05). “Eaeueiio?e” caeaoai oaeiae aieeaaoe ia aeoeai?noue oa?iaio?a nenoaie aioeieneaeaioiiai caoenoo (NIAe oa eaoaeace) iaia?ai i?e?inii oeaiei eaaaiue oa ia/?iee uo??a ca oiia A-a?iia?oai?iico, ye aeaeii c oaae.3.3. Oe? aeai? aeaiiino?othoue caeaoi?noue “ii?nueeeo” oinoie?i?ae?a ei?eaoaaoe aiiainoac ??cieo oeaiei (eaaaiue oa ia/?iee) ia ??ai? ee?oeiieo iaia?ai oeyoii noeioeyoe?? nenoaie ?o aioeieneaeaioiiai caoenoo, a naia aeoeaiinoae aioeieneaeaioieo oa?iaio?a NIAe oa eaoaeace. Oaaeeoey 3.3. Aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie caoenoo a i?e?iniiaeueieo o?aeoe?yo oeaiei eaaaiue oa ia/?iee uo??a i?e aenia?eiaioaeueiiio A-a?iia?oai?iic? oa i?e aaaaeaii? in vivo a?oai?io A ? i?aia?aoo “Eaeueiio?e” (n=7, M±m). Oiiae aeine?aeoAeoeai?noue NIAe (oi.iae/ia a?eea)Aeoeai?noue eaoaeace (eao/ia a?eea)I?e?iniie eaaaiueIi?ia13,0±0,524,70±0,29A-a?iia?oai?iic7,92±1,22*3,15±0,35A-a?iia? oai?iic+a?oai?i A12,00±0,20**8,8±1,31**A-a?iia?oai?iic+“Eaeueiio?e”10,30±0,72**5,49±0,45 **I?e?iniie ia/?ieeIi?ia7,90±0,9510,8±1,29A-a?iia?oai?iic5,43±1,0016,50±0,78*A-a?iia ?oai?iic+ a?oai?i A8,60±3,1715,75±0,56A-a?iia?oai?iic +“Eaeueiio?e”11,10±1,48**15,51±0,65** - a?aei?iiino? a??ia?aei? o ii??aiyii? c iieacieeaie, oa?aeoa?ieie aeey ii?iaeueii? a?oie (?<0,05); **- aeey a?oie c A-a?iia?oai?iicii (?<0,05). 4. Aieea oinoie?i?aeiiai eiiieaeno c ii?nueeeo i?aai?ci?a ia ei?aeoe?th neeaaeo oinoie?i?ae?a iaia?ai i?e?inii a oiiaao iaoieia?/iiai noaio ?en.4.1. A?aenioeiaee ai?no oinoie?i?ae?a o iaia?aiao i?e?inii eaaaiue uo??a (n=5, M ±m); ce?aa iai?aai: 1- eiio?ieue; 2- A-a?iia?oai?iic; 3- A-a?iia?oai?iic+a?oai?i A; 4- A-a?iia?oai?iic+”Eaeueiio?e” (*-a?aei?iiino? a??ia?aei?, ?<0,05). Aeyaeaii iaia?aiinoaa?e?coth/ee aieea “Eaeueiio?eo” o aeine?aeao in vivo ii ei?aeoe?? oinoie?i?aeiiai niaeo?o iaia?ai i?e?inii ia/?iee oa eaaaiue uo??a, ii?ooaiiai ye ca oiia A-a?iia?oai?iico, oae ? ?ioieneeaoe?? NNl4. sse iieacaii ia ?en4.1, ?en.4.2 oa ?en.4.3, aaaaeaiiy “ii?nueeeo” oinoie?i?ae?a iaeaea o 2 ?ace cieaeoaaei ai?no e?cioi?i oinoaoeaeeeoie?io oa oinoaoeaeeeaoaiieai?io iaia?ai i?e?inii iaio oeaiei, yeee cia/ii c?inoaa ca oiia A-a?iia?oai?iico oa NNl4 - ?ioieneeaoe?? ? ?, ye a?aeiii, iaeiei c iieaciee?a iaoieia??. ?en. 4.2. A?aenioeiaee ai?no oinoie?i?ae?a o iaia?aiao i?e?inii ia/?iee uo??a (n=5, M±m); ce?aa iai?aai: 1–eiio?ieue; 2- A-a?iia?oai?iic; 3- A-a?iia?oai?iic+a?oai?i A; 4- A-a?iia?oai?iic+”Eaeueiio?e” (*-a?aei?iiino? a??ia?aei?, ?<0,05). ?en. 4.3. A?aenioeiaee ai?no oinoie?i?ae?a o iaia?aiao i?e?inii ia/?iee uo??a i?e ?ioieneeaoe?? CCl4 (n=5, M±m); ce?aa iai?aai: 1– eiio?ieue; 2- CCl4; 3-+CCl4 a?oai?i A; 4- CCl4+”Eaeueiio?e” (*-a?aei?iiino? a??ia?aei?, ?<0,05). I?ney oa?ai?? A-a?iia?oai?iico uo??a “Eaeueiio?eii” aeyaeaii oaiaeaioe?th aei c?inoaiiy, a i?e oa?ai?? ?ioieneeiaaieo oaa?ei CCl4,- a??ia?aeia c?inoaiiy e?eueeino? oinoaoeaeeeoie?io oa oinoaoeaeeeaoaiieai?io o iaia?aiao i?e?inii oeaiei eaaaiue oa ia/?iee, e?euee?noue yeeo ciaiooaaeanue ca iaoieia??. Anoaiiaeaii oaeiae ii?iae?caoe?th a?aenioeiaiai ai?noo ?ioeo oinoie?i?ae?a: no?iaii??e?io, oinoaoeaeeena?eio, aeeoinoaoeaeeeae?oea?eio oa oinoaoeaeeeae?oea?eio, yeee ii?oooaaany o iaia?aiao i?e?inii i?e ianoa/? a?oai?io A /e ?ioieneeaoe?? NNl4. Ii?iae?coth/ee aieea “Eaeueiio?eo” ia aee?iieeneioiee neeaae oinoie?i?ae?a iaia?ai i?e?inii ia/?iee i?iaeaiiino?iaaii i?e ?ioieneeaoe?? oaa?ei NNl4 (oaae.4.3). Oaaeeoey 4.3. Ai?no aee?ieo eeneio o iaia?aiao i?e?inii ia/?iee i?ney ae?? NNl4 oa ia eiai oii? i?aia?aoo “Eaeueiio?e” (n=5, M±m). Oiiae aeine?aeoAEe?i? eeneioe (% a?ae noie)N 16:0N 18:0N 18:1N 18:2N 20:4N 20:5N 22:6Ii?ia22,32±0,1121,75±0,3213,58±0,3412,74±0,4015,4±0,32-1,57±0,16NNl4 22,92±0,5123,94±1,599,88±0,62*11,82±0,4721,3±0,63*-1,82±0,13NNl4+”Eaeue iio?e”26,94±0,56***27,54±1,29*16,3±0,89***19,24±0,44***11,16±0,63***0,42 ±0,012,32±0,24**-a?aei?iiino? a??ia?aei? o ii??aiyii? c iieacieeaie, oa?aeoa?ieie aeey ii?iaeueii? a?oie (?<0,05); **-aeey a?oie c NNl4 (?<0,05); ***-aeey ii?iaeueii? a?oie ? a?oie c NNl4 (?<0,05). Aaaaeaiiy uo?ai NNl4 i?ecaiaeeoue aei i?aeaeuaiiy ai?noo o oinoie?i?aeao i?e?inii ia/?iee noaa?eiiai? ? a?ao?aeiiiai? eeneioe oa cieaeaiiy iea?iiai? oa e?iieaai? eeneioe, a aaaaeaiiy “Eaeueiio?eo” iaaeeaea? oe? iieacieee aei ii?ie. Oaeei /eiii aeine?aeaeaii neeaae oinoie?i?aeiiai eiiieaeno c aieiaiiiaeo iiethne?a, iieacaii eiai iiae?ai?noue aei neeaaeo oinoie?i?ae?a i?e?iniiaeueieo iaia?ai ia/?iee oa no?oaeoaioo eaaaiue oaa?ei. Anoaiiaeaii, ui a oiiaao ieenethaaeueiiai no?ano (A-a?iia?oai?iico oa ?ioieneeaoe?? NNl4) a i?aai?ci? eiiieaen i?e?iaeieo oinoie?i?ae?a c a?ae?ia?iio?a caaacia/o? caeaoi?noue i?aai?cio ?aaoethaaoe ieenethaaeueiee aiiainoac ca ?aooiie: 1) a?aeiiaeaiiy aeoeaiino? aioeieneaeaioieo oa?iaio?a; 2) ye?nieo oa e?euee?nieo ci?i iaia?aiieo e?i?ae?a; 3) aeanoeainoae oinoie?i?ae?a neia?a?/ii i?aeneethaaoe aioeieneaeaioiee iioaioe?ae i?aai?cio. Ie??i aieeao oeueiai eiiieaeno ia nenoaio aioeieneaeaioiiai caoenoo a oeaieiao oaa?ei, yea iiae?aia aei ae?? a?oai?io A, aeyaeaii oaeiae eiai iaia?aiiei?aeoi?io ae?th, yea aea? ciiao ?aeiino?oaaoe iioeiaeaeai? ca iaoieia?/ieo oiia eiiiiiaioe iaia?ai ia ??ai? ?o oinoie?i?aeiiai oa aee?iieeneioiiai neeaaeo. Oea noaei ia?aaeoiiaith aeey ?aeiiaiaeaoe?? uiaei aeei?enoaiiy oinoie?i?aeiiai eiiieaeno c a?ae?ia?iio?a ye iiaiai aoaeoeaiiai i?aia?aoo a iaaeeoeei? oa aaoa?eia???. AENIIAEE. 1. Anoaiiaeaii, ui ii?nuee? aieiaiiia? iiethnee ? oe?iiith ne?iaeiith aeey iaea?aeaiiy oinoie?i?aeiiai eiiieaeno aeey noai?aiiy iiaeo a?ieia?/ii aeoeaieo i?aia?ao?a. Aeine?aeaeaii a?io?i?/iee neeaae iaea?aeaiiai eiiieaeno, ia iniia? yeiai noai?aii i?aia?ao “Eaeueiio?e”. 2. I?aia?ao “Eaeueiio?e” ia 80% neeaaea?oueny c oinoie?i?ae?a, aea iniiaiei eiiiiiaioii ? oinoaoeaeeeoie?i, o no?oeoo?? yeiai ? ?-iie?iaiane/ai? aeiaaieaioethaia? aee?i? eeneioe N 20:5, N 22:6. 3. Iieacaii, ui i?aia?ao “Eaeueiio?e” ? iiaa?oiaai-aeoeaiei, iiae?aiei ca a?io?i?/iei neeaaeii oa o?c?ieia?/iith ae??th aei no?oaeoaioo eaaaiue nnaaoe?a ? ni?ey? ii?iae?caoe?? ooieoe?e eaaaiue oaa?ei o ?ac? oiene/iiai aieeao ai?aeo, aaicieo, iai?ioaio. 4. Aeine?aeaeaii aioeieneaeaioi? aeanoeaino? i?aia?aoo c a?ae?ia?iio?a ia iaia?aiao i?e?inii ia/?iee oa eaaaiue. Anoaiiaeaii i?yio aioeieneaeaioio ae?th i?aia?aoo in vivo oa in vitro ? eiai noeioethth/ee aieea ia oa?iaioaoeaio nenoaio aioeieneaeaioiiai caoenoo i?aai?cio, a naia ia aeoeai?noue noia?ieneaeaeeniooace oa eaoaeace. 5. Iieacaii, ui i?aia?ao “Eaeueiio?e” ia? iaia?aiinoaa?e?coth/ee aoaeo, ni?yiiaaiee ia a?aeoai?aiiy ii?iaeueiiai oinoie?i?aeiiai oa aee?iieeneioiiai neeaaeo iaia?ai i?e?inii i?e ooo/i?e ?ioieneeaoe?? NNl4, a oiiaao ieenethaaeueiiai no?ano (A-a?iia?oai?iico). 6. ?ic?iaeaii oai?aoe/ia iaa?oiooaaiiy oa iaoiaee/i? oiiae aeey canoinoaaiiy i?aia?oo “Eaeueiio?e” ye e?eoaaeueiiai caoiaeo a eiiieaeni?e oa?ai?? caoai?thaaiue eaaaiue, ia/?iee i?e ?ioieneeaoe?yo oa ?ioeo iaoieia?yo, ye? noi?iaiaeaeothoueny ieenethaaeueiei no?anii ? ii?ooaiiyi nenoaie aioeieneaeaioiiai caoenoo i?aai?cio. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Oaoiai I.A., Aeaoeaiei C.I., Ooiaeei A.I. Aioeieneaeaioiia aeaenoaea oinoieeieaeiiai eiiieaena, auaeaeaiiiai ec ii?neeo i?aaieciia // Oe?. aeioei. aeo?i.-1994.-o.66, ?4.-N.87-95. 2. Oaoiai A.A., Aeii/aiei A.A., Aeaoeaiei C.I., Ioeaiea aeoeaiinoe noia?ieneaeaeeniooacu a iee?iniiao ?acee/iuo oeaiae e?un i?e A-iaaeinoaoi/iinoe // Oe?. aeioei. aeo?i.-1995.-o.67, ?6.-N.88-92. 3. Aeaoeaiei C.I., Aeii/aiei A.A., Oaoiai A.A., Aoa/aiei E.I., Oiaeue O.I. ?ieue oinoie?i?ae?a o iaia?aiao ooieoe?iiaeueii ??cieo ee?oei ca ii?ooaiiy aioeieneaeaioii? nenoaie // Oe?. aeioei. aeo?i.-1996.-o.68, ?1.-N.49-54. 4. Aeaoeaiei C.I., Oaoiai A.A., Aeothoneay I.A., E?eaaiei A.I. Aeeyiea oinoieeieaeia ec ii?neeo i?aaieciia ia iaiai eeieaeia iee?iniiaeueiuo iaia?ai i?e ia?ooaieyo aioeieneaeaioiie nenoaiu i?aaiecia // Iaoa?eaeu oacenia V Iaaeaeoia?iaeiie eiioa?aioeee “Aeiaioeieneaeaio”.-Iineaa, - 1998.-N.–36. AIIOAOe?ss Oaoiai I.A. Iniaeeaino? o?c?ieia?/ii? oa iaia?aiio?iiii? ae?? a?ieia?/ii aeoeaiiai oinoie?i?aeiiai eiiieaeno c a?ae?ia?iio?a. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 03.00.04-a?io?i?y. - ?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie, Ee?a, 1998. Aeena?oaoe?th i?enay/aii ieoaiiyi o?c?ieia?/ii? oa iaia?aiio?iiii? ae?? oinoie?i?aeiiai eiiieaeno c a?ae?ia?iio?a . Aeine?aeaeaii o?i?/iee neeaae oa a?ieia?/io aeoeai?noue oinoie?i?aeiiai eiiieaeno c aiiaae aieiaiiiaeo iiethne?a. Aeyaeaii, ui eiiieaen neeaaea?oueny c anaioe?aeueieo oinoie?i?ae?a, ui i?noyoue cia/io e?euee?noue a?ieia?/ii aeoeaieo aee?ieo eeneio – aeeicaiaioa?iiai? oa aeieicaaaena?iiai?. Aiie iaoiiaeththoue cia/i? iiaa?oiaai-aeoeai? aeanoeaino? eiiieaeno, ye? iiae?ai? aei no?oaeoaioo eaaaiue nnaaoe?a. Iieacaii aioeieneaeaioio ae?th eiiieaeno ? eiai noeioethth/ee aieea ia oa?iaioaoeaio oa iaoa?iaioaoeaio nenoaio aioeieneaeaioiiai caoenoo i?aai?cio nnaaoe?a. I?eionea?oueny, ui iaoai?ci ei?eaoth/i? ae?? oinoie?i?aeiiai eiiieaeno c a?ae?ia?iio?a iaoiiaeaiee ai?noii o eiai neeaae? cia/ii? e?eueeino? iie?iaiane/aieo aee?ieo eeneio. Aiane?aeie i?iaaaeaieo aeine?aeaeaiue c?iaeaii aeniiaie i?i aeioe?euei?noue aeei?enoaiiy i?aia?aoo “ii?nueeeo” oinoie?i?ae?a c iaoith ei?aeoe?? iaoaaie?/ieo ii?ooaiue, ye? noi?iaiaeaeothoueny ieenethaaeueiei no?anii, ii?ooaiiyi nenoaie aioeieneaeaioiiai caoenoo i?aai?cio, aeaoieneeaoe?eieo, ?ioiicaoenieo iaoai?ci?a oa ?aaoethth/eo ooieoe?e i?aai?cio. Eeth/ia? neiaa: oinoie?i?aee, iie?iaiane/ai? aee?i? eeneioe, no?oaeoaio, aioeieneaeaioe. AIIIOAOeEss Oaoiai A.A. Iniaaiiinoe oeceieiae/aneiai e iaia?aiio?iiiiai aeaenoaey aeieiae/anee aeoeaiiai oinoieeieaeiiai eiiieaena ec aeae?iaeiioia. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 03.00.04-aeioeiey. – Einoeooo aeioeiee ei. A.A. Iaeeaaeeia IAI Oe?aeiu, Eeaa, 1998. Aeenna?oaoeey iinayuaia aii?inai iniaaiiinoae oeceieiae/aneiai e iaia?aiio?iiiiai aeaenoaey oinoieeieaeiiai eiiieaena ec aeae?iaeiioia. Enneaaeiaai oeie/aneee ninoaa e aeieiae/aneay aeoeaiinoue oinoieeieaeiiai eiiieaena ec aiiaae aieiaiiiaeo iieethneia. Onoaiiaeaii, /oi eiiieaen ninoieo ec ynnaioeeaeueiuo oinoieeieaeia, eioi?ua niaea?aeao cia/eoaeueiia eiee/anoai aeieiae/anee aeoeaiuo aee?iuo eeneio – yeeicaiaioaaiiaie e aeieicaaaenaaiiaie. N?aaee oinoieeieaeia 70% ninoaaeyao oinoaoeaeeeoieei, eioi?ue aianoa ni cia/eoaeueii iaiueoei eiee/anoaii ae?oaeo oinoieeieaeia (oinoaoeaeeeyoaiieaiei, noeiaiieaeei, oinoaoeaeeeeiiceoie, oinoaoeaeeena?ei, oinoaoeaeeeaeeoea?eae), iaoneiaeeaaao iiaa?oiinoii-aeoeaiua naienoaa eiiieaena, iiaeiaiua no?oaeoaioo eaaeeo ieaeiieoathueo. I?e eiaaeyoeeiiiii i?eiaiaiee oinoieeieaeiiai eiiieaena (i?aia?ao "Eaeueiioee") iinea eioieneeaoeee aeeaioiuo aiieaeii, aaiceiii, iai?ioaiii iaia?oaeaia ii?iaeecaoeey ia?ooaiiuo aeenooieoeee eaaeeo: nieaeaiea eioaineaiinoe i?ioeanna iaiiia?aciaaiey, ii?iaeecaoeeth eeaoi/iie ?aaeoeee no?oaeoaioa eaaeeo, oiaiueoaiea oiene/aneiai i?ioeanna, – /oi naeaeaoaeuenoaoao i no?oaeoaioiuo naienoaao i?aia?aoa. Iieacaii aioeieneaeaioiia aeaenoaea eiiieaena e aai noeioee?othuaa aeeyiea ia oa?iaioaoeaioth e iaoa?iaioaoeaioth nenoaio aioeieneaeaioiie caueou i?aaiecia ieaeiieoathueo. I?e eco/aiee aeeyiey oinoieeieaeiiai eiiieaena ia iee?iniiaeueiua iaia?aiu oeaiae ia/aie e eaaeeo a oneiaeyo aeaoeoeeoa i?e?iaeiiai aioeieneaeaioa aeoaieia A, onoaiiaeaii aai aioeieneaeaioiia aeaenoaea ii oiaiueoaieth ia?aciaaiey i?iaeoeoia IIE, a oaeaea aai noeioee?othuaa aeeyiea ia iiauoaiea aeoeaiinoe aioeieneaeaioiuo oa?iaioia noia?ieneaeaeeniooacu e eaoaeacu. Onoaiiaeaii, /oi iieiaeeoaeueiia aeeyiea i?aia?aoa "Eaeueiioee" ia iaia?aiu ?acee/iuo oeaiae a oneiaeyo ieeneeoaeueiiai no?anna oneeeaaaony iaee/eai naiaiaeiuo iaianuuaiiuo aee?iuo eeneio e iieeiaianuuaiiuo yeeicaiieaeia a ninoaaa i?aia?aoa. E?iia aioeieneaeaioiuo e aaiaoii?ioaeoi?iuo naienoa iieacaii, /oi i?aia?ao "Eaeueiioee" i?iyaeyao iaia?aiinoaaeeece?othuea naienoaa, iai?aaeaiiua ia ii?iaeecaoeeth oinoieeieaeiiai niaeo?a a oneiaeyo ieeneeoaeueiiai no?anna, oiaiueoay eiee/anoai eecioi?i oinoieeieaeia, iiauoay o?iaaiue oinoaoeaeeeoieeia e oinoaoeaeeeyoaiieaieia, a oaeaea ainnoaiaaeeaay ninoaa aee?iuo eeneio iaia?ai. I?aaeiieaaaaony, /oi iaoaieci ei??eae?othuaai aeaenoaey oinoieeieaeiiai eiiieaena ec aeae?iaeiioia iaoneiaeai niaea?aeaieai a aai ninoaaa cia/eoaeueiiai eiee/anoaa iieeiaianuuaiiuo aee?iuo eeneio. Auoaoeacaiiua naienoaa oinoieeieaeiiai eiiieaena ec ii?neeo i?aaieciia i?iyaeythony aeaaiaea?y eo oieeaeueiiio ninoaao, aaea iniiaiui eiiiiiaioii yaeyaony oinoaoeaeeeoieei, a no?oeoo?a eioi?iai i?aiaeaaeatho iieeiaianuuaiiua aee?iua eeneiou, a oaeaea niaea?aeeony iacia/eoaeueiia eiee/anoai naiaiaeiuo aee?iuo eeneio, oieanoa?ei, aeoaiei A, ei?ioeioeaii/a/iua iaioeaeu. Aneaaenoaea i?iaaaeaiiuo enneaaeiaaiee naeaeai auaiae i oeaeaniia?aciinoe eniieueciaaiey i?aia?aoa “ii?neeo“ oinoieeieaeia aeey ei??aeoeee iaoaaiee/aneeo ia?ooaiee, eioi?ua nii?iaiaeaeathony ieeneeoaeueiui no?annii, ia?ooaieai nenoaiu aioeieneaeaioiie caueou i?aaiecia, aeaoieneeaoeeiiiuo e eiioiicaueoiuo iaoaieciia. Nicaeaiu oai?aoe/aneea i?aaeiinueee e iaoiaee/aneea oneiaey aeey i?eiaiaiey i?aia?aoa "Eaeueiioee" eae ea/aaiiai n?aaenoaa a eiiieaeniie oa?aiee caaieaaaiee ia/aie, eaaeeo, oiene/aneeo e ae?oaeo iaoieiaee, eioi?ua nii?iaiaeaeathony ia?ooaieai nenoaiu aioeieneaeaioiie caueou i?aaiecia. Eeth/aaua neiaa: oinoieeieaeu, iieeiaianuuaiiua aee?iua eeneiou, no?oaeoaio, aioeieneaeaiou. Summary Shakhman O.V. Specificities of physiological and membranotropic effects of biologically active phospholipid complex of the hydrobionts origin. – Manuscript. Thesis for a scientific degree of candidate of biological sciences by speciality 03.00.04 – biochemistry.- A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, 1998. The thesis is devoted to the peculiarities of the physiological and membranetropic action of phospholipid complex from hydrobionts. The chemical composition and biological activity of the phospholipid complex from the marine mollusca honades have been observed. It has been shown that the complex consists of essential phospholipids, which have a great number of biologically active fatty acids - eicosapentaenoic and docosahexaenoic. They cause the considerable surface-active peculiarities of this complex, which are similar to the mammals lung surfactant. The antioxidant action of the complex and its stimulating effect on the enzymatic and non-enzymatic systems of the mammals organism antioxidant protection have been shown. The hydrobionts phospholipid complex corrective effect affected by the considerable content of polyunsaturated fatty acids was suggested. The necessity of usage of “marine” phospholipids preparation in order to the correction of metabolic disoders associated with oxidative stress, alteration of antioxidant system, detoxication and immunoprotection was concluded. Key words : phospholipids, unsaturated fatty acids, surfactant, antioxidants.

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