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Оптимізація показань до вибору тактики лікування хвороби Крона тонкої і товстої кишок: Автореф. дис… канд. мед. наук / Т.Г. Кравченко, Київ. мед. ак

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I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe

?i. I.E.Ooieea

E?aa/aiei Oaoyia Aai?a??aia

OAeE 616.344-002-031.84-08-039.73-089

IIOEI?CAOe?ss IIEACAIUe

AeI AEAI?O OAEOEEE E?EOAAIIss

OAI?IAE E?IIA OIIEI? ? OIANOI? EEOIE

14.01.03 – o??o?a?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i.
I.I.Aiaiiieueoey IIC Oe?a?ie (i.Ee?a).

Iaoeiaee ea??aiee:

Aeieoi? iaaee/ieo iaoe, i?ioani?

AAEOAEO?N THE?E A?EOI?IAE*,

caa?aeoaa/ eaoaae?e oaeoeueoaonueei? o??o?a?? ?1 Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey IIC Oe?a?ie.

Io?oe?ei? iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani?

?AAeC?OIANUeEEE AIAOIE?E IAAEIAE*,

caa?aeoaa/ eaoaae?e o??o?a?? oa ii?eiai? oai?iae Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea IIC Oe?a?ie.

2. Aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee

EEEIOUe AIEIAeEIE? IIOO??EIAE*,

noa?oee iaoeiaee ni?a?ia?oiee a?aeae?eo aaaeii?iaeueii? iieieia??
Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo iieieia?? oa ?aae?ieia??
IIC Oe?a?ie.

I?ia?aeia onoaiiaa:

?inoeooo ee?i?/ii? oa aenia?eiaioaeueii? o??o?a?? AII Oe?a?ie, a?aeae?e
o??o?a?? oeoieiai-eeoeiaiai o?aeoo.

Caoeno a?aeaoaeaoueny 05.11.1999 ?ieo i14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.613.02

i?e Ee?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea.
(254112, i. Ee?a, aoe. Aei?iaiaeeoeueea, 9).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea.

(i.Ee?a, aoe. Aei?iaiaeeoeueea, 9).

Aaoi?aoa?ao ?ic?neaiee 05.10. 1999 ?ieo.

A/aiee nae?aoa?

niaoe?aeiciaaii? ?aaee,

e.i.i., aeioeaio
I.I. Aaicaeye

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie Aeooaeuei?noue i?iaeaie oai?iae E?iia (OE)
iaoiiaeaia ye iaaee/ieie, oae ? nioe?aeueieie oaeoi?aie.

Nioe?aeueiee aniaeo i?iaeaie iieyaa? o anac?inoath/iio ??ai? ia?aeiii?
caoai?thaaiino?, yea ui??/ii nyaa? 5-10 iiaeo aeiaaee?a ia 100000
ianaeaiiy (V.Binder,1995). I?e ia?aeiii? caoai?thaaiino? i?eiaaea? ia
ae?oao oa o?aoth aeaeaaee aeeooy, ioaea ? iaea?eueoa e?euee?noue
caoai??aoeo – iniae iieiaeiai, iaea?eueo i?aoeacaeaoiiai a?eo (P.R.
Eliot, 1992; J.Emmrich, 1998).

Iaaee/iee aniaeo i?iaeaie oa?aeoa?eco?oueny iaeiaea/aiei
ao?iiaoiaaiacii, oyaeeei iai?iaiiciaaiei ia?aa?aii, a?aenooi?noth
ia’?eoeaieo e?eoa???a ioe?iee noaio iaoe??io?a oa noa’?eoeai?noth o
aeai?? e?eoaaeueii? oaeoeee (G.D’Haens, 1998; A.Otley,1999).

Eiina?aaoeaia e?eoaaiiy OE iaeiaoaeoeaia. ?nioth/? caniae
iaaeeeaiaioicii? oa?ai?? ae?thoue eeoa ia ie?ai? eaiee iaoiaaiaco, a
?ecee ?o canoinoaaiiy ia??aeei ia?aaeuo? oa?aiaaoe/iee aoaeo (A.A.
A?eai?ueaaa, 1996; J.Scholmerich, 1997, M.Robinson, 1998).

O??o?a?/ia e?eoaaiiy ia?aaeeeaeueia uiaei naii? OE, a ? eeoa ?aca?aii
aeey e?eoaaiiy oneeaaeiaieo oa ?ao?aeoa?ieo aei iaaeeeaiaioicii? oa?ai??
oi?i caoai?thaaiiy (TH.A.Aaeoaeo?n, 1997; A.Gaudio,1998).
?iaae?aeecoth/ee oa?aeoa? iaoe?ieo ?acaeoe?e eeoe?aieea oa aeniea
/anoioa i?neyiia?aoe?eieo ?aoeeaeea?a (35% i?ioyaii ia?oiai ?ieo)
ciooothoue o??o?a?a aeaaaeaii i?aeoiaeeoe aei aeeiiaiiy iia?aoeaieo
ao?o/aiue. A oie aea naiee /an, caa?ica aeieeiaiiy iaaacia/ieo
oneeaaeiaiue ia aea? iiaeeeaino? caie?eaoe c o??o?a?/iei e?eoaaiiyi
(L.P.Frizelle,1996; M.G.W. Kettwel, 1997; TH.A.Aaeoaeo?n,1997).
Iaaecia/aieie ia oeae /an caeeoathoueny a?aeiini? iieacaiiy aei
ia?aeiieo iia?aoe?e, iioeiaeueiee oa?i?i oa niin?a ?o aeeiiaiiy
(B.Bohm,1995; TH.A.Aaeoaeoen,1997).

Aeeneon?eiei ? ieoaiiy aeeiiaiiy ia?aeiii-a?aeiiaieo iia?aoe?e i?e OE:
?aea? iaeiiiiiaioiiai a?aeiiaeaiiy aacia?a?aiino? eeoe?aieea, yea ni?ey?
iie?auaiith ooieoe?iiaeueieo ?acoeueoao?a e?eoaaiiy oa ?aaa?e?oaoe??
iia?iaaieo iaoe??io?a, eiieo?othoue c i?aaiaiiyi iiia?aaeeoe
i?neyiia?aoe?ei? oneeaaeiaiiy oa ?aoeeaeeae c aieo noi?iiaaiiai
aianoiiico. Ia’?eoeai? e?eoa??? a?aeai?o noiiiaaieo iaoe??io?a aei
?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e ua e aein? /?oei ia aecia/ai?
(M.Hashemi, 1998, H.J.Buhr, 1998., T.Yamamoto, 1999).

Oaeei /eiii, iaea?eueo ia?niaeoeaiei iai?yieii ae??oaiiy i?iaeaie
e?eoaaiiy OE – caoai?thaaiiy, ao?ieia?y eio?iai ana ua caeeoa?oueny
iaaecia/aiith, ? ia’?eoea?caoe?y e?eoaaeueii? oaeoeee oa ?ic?iaea
aoaeoeaieo cania?a eiina?aaoeaii? oa?ai??, ye? a ni?eyee i?i?i?caoe??
iieacaiue aei o??o?a?/iiai e?eoaaiiy OE oa iie?auaiith eiai
?acoeueoao?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie Aeena?oaoe?eia
?iaioa ? o?aaiaioii iaoeiai-aeine?aeii? ?iaioe eaoaae?e oaeoeueoaonueei?
o??o?a?? ?1 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey
“I?io?eaeoeea ? e?eoaaiiy ai?eii-naioe/ieo oneeaaeiaiue i?ney iia?aoe?e
ia i?aaiao /a?aaii? ii?iaeieie c iaoith i?aeaeuaiiy aoaeoeaiino?
e?eoaaiiy”, ? aea?ae?a?no?aoe?? 0194 E017979.

Iaoa ? caaea/? aeine?aeaeaiiy Iniiaiith iaoith aeine?aeaeaiiy ?
iie?ioaiiy ?acoeueoao?a e?eoaaiiy OE oiiei? ? oianoi? eeoie oeyoii
canoinoaaiiy iioei?ciaaii? e?eoaaeueii? oaeoeee, yea a ni?eyea
i?i?i?caoe?? iieacaiue aei o??o?a?/iiai e?eoaaiiy, ca?eueoaiith a
caaaeuei?e no?oeoo?? iia?aoeaieo ao?o/aiue /anoee ia?aeiii-a?aeiiaieo oa
i?aaiicaa??aath/eo iia?aoe?e, cieaeaiith /anoioe i?neyiia?aoe?eieo
oneeaaeiaiue oa ?aoeeaeea?a, iie?ioaiith ?acoeueoao?a iaaee/ii? oa
nioe?aeueii? ?aaa?e?oaoe?? iia?iaaieo iaoe??io?a.

Aeey aeinyaiaiiy iinoaaeaii? iaoe iaiao?aeii aoei ae??oeoe oae? caaea/?:

1. Aea/eoe oa ioe?ieoe i?e/eie iacaaeia?eueieo ?acoeueoao?a
eiina?aaoeaiiai ? o??o?a?/iiai e?eoaaiiy OE oa aecia/eoe iiaeeea? oeyoe
?o iie?auaiiy.

2. Ii?aoethaaoe e?eoaaeueio oaeoeeo, yea a ni?eyea i?i?i?caoe??
iieacaiue aei ia?aeiieo iia?aoe?e oa iie?ioaiith ?acoeueoao?a
o??o?a?/iiai e?eoaaiiy OE.

3. Aeine?aeeoe aoaeoeai?noue aoaeanii?aeo – i?aia?aoo c a?oie eieaeueii
ae?th/eo aetheiei?oeei?ae?a aeey e?eoaaiiy aeoeaii? OE oiiei? ? oianoi?
eeoie, aecia/eoe iioeiaeueio oa?aiaaoe/io aeico i?aia?aoa oa /?oe?
iieacaiiy aei eiai canoinoaaiiy.

4. Aecia/eoe ia’?eoeai? e?eoa??? ioe?iee aoaeoeaiino? iaaeeeaiaioicii?
oa?ai??, iioeiaeueiee oa?i?i oa a?aeiini? iieacaiiy aeey ia?aoiaeo a?ae
eiina?aaoeaiiai aei iia?aoeaiiai e?eoaaiiy o aeiaaeeao ?ao?aeoa?ieo aei
iaaeeeaiaioicii? oa?ai?? oa oneeaaeiaieo oi?i OE.

5. Aecia/eoe iioeiaeuei? niiniae iia?aoeaieo ao?o/aiue oa i?noea
eaia?ineii?/ieo oaoiieia?e a o??o?a?/iiio e?eoaaii? OE oiiei? ? oianoi?
eeoie.

6. Aecia/eoe ia’?eoeai? e?eoa??? a?aeai?o noiiiaaieo iaoe??io?a c OE aei
aeeiiaiiy aoi?eiii-a?aeiiaieo iia?aoe?e oa iiaeeea? oeyoe ?icoe?aiiy
iieacaiue aei ieo.

7. Ioe?ieoe ?acoeueoaoe ?ic?iaeaii? e?eoaaeueii? oaeoeee oa ?? aieea ia
iie?ioaiiy ?acoeueoao?a o??o?a?/iiai e?eoaaiiy OE.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a Aia?oa aecia/aii iioeiaeuei?
oa?aiaaoe/i? aeice oa /?oe? iieacaiiy aei canoinoaaiiy ia?i?aeueieo oi?i
aoaeanii?aeo, aeiaaaeaii eiai aenieo aoaeoeai?noue oa aacia/i?noue aeey
e?eoaaiiy aeoeaii? OE oiiei? ? oianoi? eeoie.

Aecia/aii ia’?eoeai? e?eoa??? ioe?iee noaio iaoe??io?a, aoaeoeaiino?
iaaeeeaiaioicii? oa?ai?? oa aeai?o iiaeaeueoi? e?eoaaeueii? oaeoeee.

Ca aeiiiiiaith ?ic?iaeaii? i?eioeeiiai iiai? e?eoaaeueii? oaeoeee
aeiaaaeaii iaiao?aei?noue canoinoaaiiy a ia?aaeiia?aoe?ei?e i?aeaioiaoe?
no/anieo i?aia?ao?a aacenii? oa?ai?? oa aeeiiaiiy iia?aoeaieo ao?o/aiue
ia ?aii?o aoaiao caoai?thaaiiy, ui ni?ey? iie?ioaiith ?acoeueoao?a
o??o?a?/iiai e?eoaaiiy OE.

Aecia/aii a?aeiini? iieacaiiy aei ia?aeiieo iia?aoe?e i?e OE oiiei? ?
oianoi? eeoie, iioeiaeuei? oa?i?ie oa niiniae ?o aeeiiaiiy,
aaciina?aaei?i a?aeia?aaeaiiyi /iai ? iie?auaiiy ?acoeueoao?a iaaee/ii?
oa nioe?aeueii? ?aaa?e?oaoe?? iia?iaaieo iaoe??io?a.

Aeciaii, ui e?euee?noue ?eainoiiieo aeii?iaeiaiue ? iaeiei c ia’?eoeaieo
e?eoa???a a?aeai?o noiiiaaieo iaoe??io?a c OE aei aeeiiaiiy
aoi?eiii-a?aeiiaieo iia?aoe?e oa aia?oa cai?iiiiiaaii oeyoe ?icoe?aiiy
iieacaiue aei ieo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a Aeiaaaeaia a ?acoeueoao?
aeine?aeaeaiue aeniea aoaeoeai?noue aoaeanii?aeo, aecia/ai? iioeiaeuei?
oa?aiaaoe/i? aeice ? iieacaiiy aei eiai canoinoaaiiy aeathoue
iiaeeea?noue aeeth/eoe i?aia?ao aei iaaaaaoiai a?naiaeo cania?a aacenii?
oa?ai?? OE oiiei? ? oianoi? eeoie.

Canoinoaaiiy ?iaeaeno Aanoa aeey ioe?iee noaio iaoe??io?a oa
aoaeoeaiino? iaaeeeaiaioicii? oa?ai?? aeicaiey? ia’?eoea?coaaoe
e?eoaaeueio oaeoeeo i?e OE.

Ia’?i oiieieeoeiaeo aeae?eaiue o noiiiaaieo iaoe??io?a c OE aia?oa
aeciaii iaeiei c ia’?eoeaieo e?eoa???a a?aeai?o aei
?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e, a ciaioaiiy ?o e?eueeino? i?e
canoinoaaii? aoaeanii?aeo – iaeiei c iiaeeeaeo oeyo?a ?icoe?aiiy
iieacaiue aei aoi?eiii-a?aeiiaieo iia?aoeaieo ao?o/aiue.

Canoinoaaiiy ?ic?iaeaii? e?eoaaeueii? oaeoeee aeicaiey? iie?ioeoe
?acoeueoaoe e?eoaaiiy OE, aaciina?aaei?i a?aeia?aaeaiiyi /iai ?
i?i?i?caoe?y iieacaiue aei o??o?a?/iiai e?eoaaiiy, ca?eueoaiiy a
caaaeuei?e nooeoo?? iia?aoeaieo ao?o/aiue /anoee aeiiiiieo ?acaeoe?e
eeoe?aieea, ia?aeiii-a?aeiiaieo oa no?ieoa?caa??aath/eo iia?aoe?e,
cieaeaiiy /anoioe i?neyiia?aoe?eieo oneeaaeiaiue ? ?aoeeaeea?a,
nei?i/aiiy oa?i?i?a iaaee/ii? oa nioe?aeueii? ?aaa?e?oaoe?? iia?iaaieo
iaoe??io?a.

?ic?iaeaio e?eoaaeueio oaeoeeo ai?iaaaeaeaii a i?aeoeeo I?ieoieia?/iiai
oeaio?o oa i?ieoieia?/ieo a?aeae?eaiue Oe?a?ie. Iaoa??aee
aeena?oaoe?eii? ?iaioe aeei?enoiaothoueny i?ae /an i?iaaaeaiiy
i?aeoe/ieo caiyoue oa eaeoe?e ia eaoaae?? oaeoeueoaonueei? o??o?a?? ?1
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaieiiueoey IIC Oe?a?ie.

Iniaenoee aianie aeena?oaioa Ee?i?/i? aeine?aeaeaiiy i?iaaaeai?
aaoi?eith naiino?eii ia aac? eaoaae?e oaeoeueoaonueei? o??o?a?? ?1 IIO
oa I?ieoieia?/iiai oeaio?o Oe?a?ie. I?ioieiee ee?i?/ieo aeine?aeaeaiue
?ic?iaeai? aaoi?eith o ni?ai?aoe? c eiiiai??th c ee?i?/ieo
aeine?aeaeaiue Euro Bio-Pharm (I?ia//eia). Eaai?aoi?i? aeine?aeaeaiiy
i?iaaaeai? ca o/anoth aaoi?ee a eaai?aoi??? EIEE ?18 (caa. eaai?aoi???th
e.i.i. A.?.Aaeea?) oa ?inoeooo? eaai?aoi?ii? iaaeeoeeie (i.Oaeaeaeaa?a,
I?ia//eia).

Aaoi?eith naiino?eii i?iaaaeaii iaoaioiee iiooe, aiae?c e?oa?aoo?e,
noaoenoe/io ia?iaeo iaea?aeaieo ?acoeueoao?a, iaienaii an? ?icae?ee
aeena?oaoe??, noi?ioethaaii aeniiaee oa i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe?? Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe aeeeaaeai? oa iaaiai?ai? ia 3-e i?aeia?iaei?e eiioa?aioe??
“I?iaeaiu ?aaaeeeoaoeee i?ieoieiae/aneeo aieueiuo” (Aeoaane, 21-22 iay
1998a.), Falk Symposium “New Aspects in Hepatology and Gastroenterology”
(Tbilisi/Tiflis, May 29-30, 1998), Polisn-Belorussian-Ukrainian Falk
Symposium “New Concepts on Etiopathogenesis and Treatment of
Inflammatory Bowel Disease” (Warsaw/Poland, September 10-11, 1999).

Ioae?eaoe?? Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 6 iaoeiaeo ?ia?o:
3 – o oaoiaeo a?o/eciyieo aeo?iaeao, 3 – o iaoa??aeao i?aeia?iaeieo
neiiic?oi?a oa eiioa?aioe??.

No?oeoo?a oa ia’?i aeena?oaoe?? Iniiaiee oaeno aeena?oaoe?? aeeeaaeaiee
oe?a?inueeith iiaith ia 118 noi??ieao iaoeiiieniiai oaenoo ?
neeaaea?oueny ?c anooio, i’yoe ?icae?e?a (iaeyaeo e?oa?aoo?e, ?icae?eo c
iienii iaoa??aeo oa iaoiae?a aeine?aeaeaiiy, o?ueio ?icae?e?a aeanieo
aeine?aeaeaiue), caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e,
nieneo aeei?enoaii? e?oa?aoo?e oa o?ueio aeiaeaoe?a. ?iaioa ?ethno?iaaia
29 oaaeeoeyie oa 19 ?enoieaie. Nienie e?oa?aoo?e neeaaea?oueny c 436
aeaea?ae: 31 – ?iaioe a?o/eciyieo aaoi??a, 405 – ?iaioe ca?oa?aeieo
aaoi??a.

INIIAIEE CI?NO ?IAIOE

Oa?aeoa?enoeea oai?eo ? iaoiaee aeine?aeaeaiiy A iniiao ?iaioe
iieeaaeaii ?acoeueoaoe e?eoaaiiy 222 iaoe??io?a c OE oiiei? ? oianoi?
eeoie, ye? ia?aaoaaee ia e?eoaaii? a ee?i?oe? eaoaae?e oaeoeueoaonueei?
o??o?a?? ?1 IIO c 1991 ii 1998 ??. (8 ?ie?a).

Aeey aeinyaiaiiy iaoe oa ae??oaiiy caaea/ aeine?aeaeaiiy aeeiiaiiy
aeena?oaoe?eii? ?iaioe aoei ?iciiae?eaii ia aeaa aoaie. Ia ia?oiio aoai?
aeine?aeaeaiiy ia a?o?aiiio iaoa??ae? ee?i?ee aea/aii ?acoeueoaoe
e?eoaaiiy 113 iaoe??io?a c OE ca ia??iae 1991-1994??., aecia/aii i?e/eie
iacaaeia?eueieo ?acoeueoao?a e?eoaaiiy oa iiaeeea? oeyoe ?o iie?auaiiy.
Ia ae?oaiio aoai?, a?aooaaaoe an? iaaeie?ee e?eoaaeueii? oaeoeee
1991-1994??., ?ic?iaeaii i?eioeeiiai a?aei?iio oaeoeeo e?eoaaiiy ?
iieeaaeaii ?? a iniiao e?eoaaiiy 109 iaoe??io?a c OE a 1995-1998 ??.
Oaeei /eiii, aoei aeae?eaii 2 a?oie iaoe??io?a: eiio?ieueia
(1991-1994??.) – 113 in?a oa aeine?aeaeoaaia (1995-1998??.) – 109 in?a.

Iaeaea? a?oie aoee ?ai?acaioaoeaieie ca a?eiaei, noaoaaei neeaaeii oa
iniiaieie ee?i?/ieie oa?aeoa?enoeeaie caoai?thaaiiy. I?eioeeiiai
a?aei?iieie uiaei ieo aoee e?eoaaeueia oaeoeea oa oa?aeoa?
iaaeeeaiaioicii? oa?ai??.

Ia iniaeeao oaaao caneoaiaoaaee iia?iaai? iaoe??ioe iaio a?oi, oiio ui
oea aoee iaoe??ioe c oeie oi?iaie OE, iaaeeeaiaioicia oa?i?y yeeo
aeyaeeanue iaeioaeoeaiith. Eiaeia c a?oi aoea ?iciiae?eaia ia aea?
i?aea?oie a caeaaeiino? a?ae canoiniaaiiai e?eoaaiiy – eiina?aaoeaiiai
/e iia?aoeaiiai. Ii??aiyiiy ni?aa?aeiioaiiy iia?iaaieo oa iaiia?iaaieo
iaoe??io?a iaio a?oi iieacaei, ui a eiio?ieuei?e a?oi? iia?iaaieo
iaoe??io?a aoei aeinoia??ii a?eueoa, i?ae a aeine?aeaeoaai?e: 37,174,55%
i?ioe 22,023,97%, P350) oa eieae?caoe??th i?ioeano a oa?i?iaeueiiio
a?aeae?e? eeoaiai? eeoee, oiano?e eeooe? oa cii? oiiei-oianoieeoeiaiai
aianoiiico. O eiaeiiai c iaoe??io?a aeine?aeaeaiiy o?eaaei 777 aei?a.
Aeey ia’?eoeaii? ioe?iee noaio iaoe??io?a oa aoaeoeaiino? e?eoaaiiy
canoiniaoaaee aeniei?ioi?iaoeaio nenoaio aaaaoioaeoi?iiai aiae?co –
?iaeaen Aanoa, yeee ? caaaeueii i?eeiyoiei ee?i?/ii cia/ouei ia?aiao?ii
? aeei?enoiao?oueny o an?o eiio?ieueiaaieo ee?i?/ieo aeine?aeaeaiiyo,
i?ena’y/aieo OE. Ciaioaiiy ?iaeaeno Aanoa i?ioyaii e?eoaaiiy ia 60 iae.
oa a?eueoa aaaaea?oueny ?iaeeeaoi?ii ?aa?an?? caaino?aiiy OE, a ?iaeaen
Aanoa0,05), a oei/aniaa cieaeaiiy ??aiy
aacaeueiiai ei?oecieo ia?aaoaaei a iaaeao i?eionoeieo aaee/ei ? iaei
aaeaioaoe?eiee oa?aeoa?. I?ney cae?i/aiiy aeine?aeaeaiiy na?aaei?e
??aaiue aacaeueiiai ei?oecieo ia a?ae??ciyany a?ae ii/aoeiaiai ? aoa
ieae/ei eeoa ia 3,9%.

Aiae?c ?acoeueoao?a ee?i?/iiai aeine?aeaeaiiy aoaeanii?aeo aeicaieea
aecia/eoe /?oe? iieacaiiy aei eiai canoinoaaiiy.

1. Eieae?caoe?y caiaeueii-?io?eueo?aoeaieo ci?i o oa?i?iaeueiiio
a?aeae?e? eeoaiai? eeoee, o i?aa?e iieiaei? iaiaeiai? eeoee oa a cii?
oiiei-oianoieeoeiaeo aianoiiic?a. O aeiaaeeao o?aaeaiiy ?ioeo a?aeae?e?a
oianoi? eeoee aoaeoeai?noue aeiaeii? c aeic aoaeanii?aeo ia aoea
aeinoaoiueith.

2. Oi?ie OE oiiei? ? oianoi? eeoie, ia?aa?a yeeo ia oneeaaeiaiee
iicaeeoeiaeie i?iyaaie oa caiaeueieie ?io?eueo?aoaie a /a?aai?e
ii?iaeiei?.

Aoaeoeai?noue 3ia aoaeanii?aeo aeey e?eoaaiiy aeoeaii? OE oiiei? oa
oianoi? eeoee aeyaeeanue iaaeinoaoiueith. Aoaeoeai?noue 18ia
aoaeanii?aeo noaoenoe/ii aeinoia??ii ia a?ae??ciyeanue a?ae aoaeoeaiino?
9ia aoaeacii?aeo, aea /anoioa noa?i?aeicaeaaeieo iia?/ieo neiioii?a aoei
aeuith – 62,5±8,2% i?ioe 37,5±6,3%, P 0,05· eaoaeuei?noue19,1%4,2%14,9%

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