EUeA?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?i. Ae. Aaeeoeueeiai

IAIIIANUeEEE

?iiai C?iia?eiae/

OAeE: 617.527-089.843-032:/611-013.3:591.3/

IIOEI?CAOe?ss EIINIE?AeAOe?? CEAI?A IEAEIUeI? UAEAIE IAOIAeII
EE?OEIII? ENAIIA?AOIO?AINIEAIOAOe??(aenia?eiaioaeueii-ee?i?/ia
aeine?aeaeaiiy)

14.01.22 «Noiiaoieia?y»

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Euea?a – 1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
Ae.Aa-eeoeueeiai IIC Oe?a?ie

IAOEIAEE EA??AIEE

eaiaeeaeao iaaee/ieo iaoe, i?ioani? Aioue ?aai Ie?ineaaiae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? noiiaoieia?? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo.

Io?oe?ei? iiiiaioe

aeieoi? iaaee/ieo iaoe, aeioeaio Aiae TH??e Aieiaeeie?iae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? oa i?oiiaaee/ii? noiiaoieia??
oaeoeueoaoo i?neyaeeieiiii? ina?oe Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

aeieoi? iaaee/ieo iaoe, i?ioani? ?oc?i Aaiiaae?e I?iooniae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? noiiaoieia?? Oa?e?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo.

I?IA?AeIA ONOAIIAA

eaoaae?a aeeoy/i? o??o?a?/ii? noiiaoieia?? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. I.I.Aiaiiieueoey.

Caoeno a?aeaoaeaoueny “ 9 ” eaioiy 1999 ?ieo i 1100 aiae. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.600.01 o Euea?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (290010, i. Euea?a, aoe.
Iaea?nueea, 69).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (290000, i. Euea?a, aoe. N?/iaeo
no??eueoe?a, 6).

Aaoi?aoa?ao ?ic?neaiee “ 27 ” ethoiai 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee *OEE?I N.I.- 1 —

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aea/aiiy i?ioean?a ?aia?aoeaiiai inoaiaaiaco oa
iaoiae?a eiai iioei?caoe?? ia aeaiee /an caeeoa?oueny iaeiei ?c
aaaeeeaeo iai?yie?a iaoeiaeo aeine?aeaeaiue (Eaaeoeeee A.I., Einaiei
E.I., 1997). Nueiaiaei? aeine?aeaeaiiy iaoeiaoe?a ni?yiiaai? ia aea/aiiy
a?ieia?/ieo iaoiae?a aieeao ia ?aia?aoeai? i?ioeane, i?e yeeo, aac
aeiaeaoeiai? o?aaie i?aeaeuo?oueny eiioeaio?aoe?y a?ieia?/ii aeoeaieo
?a/iaei o ae?eyioe? iioeiaeaeaiiy. Ia?niaeoeaiith, cie?aia, ?
o?ainieaioaoe?y noniaic?? aia??iiaeueieo ee?oei.

O ca’yceo c o?oaeiiuaie a io?eiaii? aeinoaoiuei? e?eueeino? ethaenueeiai
aia??iiaeueiiai iaoa??aeo, inoaii?i /anii i?iaiaeyoueny aeine?aeaeaiiy
ee?oeiieo enaiiaaiieo a?aoio?ainieaioao?a. I?e ?o aea/aii? aeyaeaii
iecuee? aioeaaii? aeanoeaino?, a?aenooi?noue nainea?e?caoe?? o
ia?aaaaeii? a?eueoino? ?aoeei??io?a i?ney ia?anaaeee (Aiaaeei A.E.,
Aeaaeiaa A.Ae. c ni?aaao., 1983).

Iioei?caoe?y oa aeoeaaoe?y ?aia?aoeaiiai inoaiaaiaco iniaeeai aeooaeueia
i?e ceaiao ieaeiuei? uaeaie, ui iiynith?oueny cia/iith ?o e?euee?noth
(20-30% an?o noaoe?iia?ieo oai?eo c uaeaiiai-eeoeaaith iaoieia??th), oa
aeiaaio?eaaeei (3-4 oeaei?) e?eoaaiiyi (Oa?ueeia E.A., Eooeaaeye A.E.,
1997).

Aeooaeuei?noue i?iaeaie iieyaa? ua e o cia/iiio a?aenioeo ??ciiiai?oieo
oneeaaeiaiue (aei 31%), na?aae yeeo aeineoue /anoi cono??/a?oueny
niia?eueiaia eiinie?aeaoe?y oa ooai?aiiy oeaieo noaeia?a (Eaaeoia A.I.,
?oaaiaiei A.A., Ei?ieue I.Ae., 1995). Aeine?aeaeaiiy inoaii?o ?ie?a
na?ae/aoue i?i oa, ui aeey iaeiinie?aeiaaieo ceai?a, oeaieo noaeia?a
oa?aeoa?i? iciaee i?eai?/aiiy aeoeaiino? ee?oei e?noeiaiai iiceo, ui
ni?e/eiy? iaiao?aei?noue i?aeaeuaiiy inoaiaaiii? iioaioe?? a oeaieiao
o?aaiiaaii? ae?eyiee (Iaeai/oe A.I. 1994).

Ca iniiao, ye i?ioioei aeey aeine?aeaeaiue, aeei?enoaii ?iaioo i?io.
A?eioniaa A.Ae. c ni?aaao. (1990), yeeie canoiniaaii o?ainieaioaoe?th
noniaic?? aia??iiaeueieo e?noeiaiiiceiaeo eo?y/eo ee?oei (aeae? ca
oaenoii — AEEE) o o?aaiaoieia?? i?e e?eoaaii? oai?eo c oneeaaeiaieie
ceaiaie aeiaaeo o?oa/anoeo e?noie. I?e iaeyae? e?oa?aoo?e ia aeyaeaii
aeaieo i?i aeei?enoaiiy oeueiai iaoiaeo a noiiaoieia?? i?e e?eoaaii?
iaoneeaaeiaieo oa oneeaaeiaieo ceai?a ieaeiuei? uaeaie, aeey yeeo
oa?aeoa?i? iniaeeaino? ia?aa?ao i?ioean?a eiinie?aeaoe?? aiane?aeie
aiaoii?/ii? aoaeiae, e?iaiiinoa/aiiy oa niaoeeo?/ii? ooieoe?? (O?acaeei
AE.A., Eo?uea O.I., Eiiieeoia A.E., 1985).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?eii? ?iaioe ? neeaaeiaith /anoeiith iaoeiai-aeine?aeii?
?iaioe eaoaae?e o??o?a?/ii? noiiaoieia?? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo “Aeaoi?iaoe?? eeoeaaiai neaeaoo o ae?oae c
a?iaeaeaieie iac?iuaiiyie aa?oiuei? aoae ? i?aeiaa?iiy aei ? i?ney
o??o?a?/iiai e?eoaaiiy oa iaoiaee ?o ei?aeoe??. ?ic?iaea ?
aenia?eiaioaeuei? aeine?aeaeaiiy canoinoaaiiy ?ioii-?iaeeoa?aioiiai
ieanoe/iiai iaoa??aeo”. ? aea?ae?a?no?aoe?? 02010793.

Iaoa aeine?aeaeaiiy. I?aeaeueoe aoaeoeai?noue, nei?ioeoe oa?i?ie
e?eoaaiiy oa ?aaa?e?oaoe?? oai?eo c iaoneeaaeiaieie oa oneeaaeiaieie
ceaiaie ieaeiuei? uaeaie.

Caaaeaiiy aeine?aeaeaiiy.

1. Aineiiaeeoe iaoiaeeeo io?eiaiiy o?ainieaioaoo noniaic?? AEEE.

2. Aecia/eoe aieea o?ainieaioaoo ia ?ioaineai?noue ?inoo o?a?iaeano?a
ethaeeie i?e ?o eoeueoeaoaaii? in vitro.

3. Aeine?aeeoe a aenia?eiaio? ia oaa?eiao inoai?iaeoeoeai? aeanoeaino?
noniaic?? AEEE i?e aeoii?/i?e ia?anaaeoe?.ae

4. I?iaanoe ii??aiyeueiee aiae?c a aenia?eiaio? aeeiai?ee ii?oiaaiaco
a?aeiiaeaiiy e?noeiai? oeaieie a ooo/ii noai?aieo aeaoaeoao ieaeiuei?
uaeaie i?e ee?oeii?e enaiia?aoio?ainieaioaoe?? oa aac ia?.

5. Aea/eoe a ee?i?oe? aoaeoeai?noue canoinoaaiiy aeaiiai o?ainieaioaoo
i?e eiiieaeniiio e?eoaaii? oai?eo c iaoneeaaeiaieie oa oneeaaeiaieie
ceaiaie ieaeiuei? uaeaie oa i?iaanoe ii??aiyeueio ioe?ieo ?acoeueoao?a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

1. Ai?iaaaeaeaii oa?i?/io ia?iaeo i?e caaioiaeaii? o?ainieaioaoe?eiiai
iaoa??aeo oa iaa?oioiaaii ?? iaiao?aei?noue.

2. Ia i?aenoaa? ?acoeueoao?a ?aae?i?cioiiiiai aeine?aeaeaiiy
?ioaineaiino? i?ie?oa?aoe?? ethaenueeeo o?a?iaeano?a o eoeueoo?? in
vitro anoaiiaeaii aoaeoeai?noue ?i?oe?thth/iai oa aeoeaoth/iai aieeao
o?ainieaioaoo.

3. Aea/aii i?ioeane aeoii?/iiai e?noeiooai?aiiy i?e aaoa?ioii?/i?e
o?ainieaioaoe?? noniaic?? AEEE a aenia?eiaio?.

4. I?iaiae?ciaaii i?ioeane ?aia?aoeaiiai inoaiaaiaco i?e caai?ii? ooo/ii
noai?aieo aeaoaeo?a ia ieaei?e uaeai? a oiiaao aenia?eiaioo i?e
enaiia?aoio?ainieaioaoe?? oa aac ia?, i?iaaaeaia ?o ii??aiyeueia
oa?aeoa?enoeea.

5. ?ic?iaeaii oa ai?iaaaeaeaii a ee?i?eo niin?a eiiieaeniiai e?eoaaiiy
iaoneeaaeiaieo oa oneeaaeiaieo ceai?a ieaeiuei? uaeaie c
o?ainieaioaoe??th noniaic?? AEEE.

6. I?iaaaeaii ii??aiyeueio oa?aeoa?enoeeo e?eoaaiiy ceai?a ieaeiuei?
uaeaie a oai?eo ?c o?ainieaioaoe??th noniaic?? AEEE oa aac ia?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iiceoeai? ?acoeueoaoe
aenia?eiaioaeueieo aeine?aeaeaiue aeaee iiaeeea?noue canoinoaaoe
o?ainieaioaoe?th noniaic?? AEEE o ee?i?/ieo oiiaao i?e eiiieaeniiio
e?eoaaii? oai?eo c iaoneeaaeiaieie oa oneeaaeiaieie ceaiaie ieaeiuei?
uaeaie. Cai?iiiiiaaia iaie iaoiaeeea aeicaieeea nei?ioeoe oa?i?ie
i?aeuaeaiiai? ?iiia?e?caoe?? oa e?eoaaiiy oai?eo c iaoneeaaeiaieie
ceaiaie ieaeiuei? uaeaie, oieeiooe a /enaeueieo aeiaaeeao a?eueo
o?aaiaoe/iiai iia?aoeaiiai e?eoaaiiy oa iie?aueoe caai?iiy ceai?a i?e
niia?eueiai?e eiinie?aeaoe??.

Cai?iiiiiaaiee niin?a eiiieaeniiai e?eoaaiiy iaoneeaaeiaieo oa
oneeaaeiaieo ceai?a ieaeiuei? uaeaie c canoinoaaiiyi ee?oeiii?
enaiia?aoio?ainieaioaoe?? ai?iaaaeaeaiee a a?aeae?eao uaeaiiai-eeoeaai?
o??o?a?? Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, Euea?anueei? i?nueei?
ee?i?/ii? e?ea?i? oaeaeei? iaaee/ii? aeiiiiiae, Aieeinueei? iaeanii?
e?ea?i?, *a?i?aaoeueei? iaeanii? ee?i?/ii? e?ea?i?, a?aeae?e? o??o?a??
Ioea/?anueei? ?aeiiii? e?ea?i? Caea?iaonueei? iaeano?. Iaoa??aee
aeena?oaoe?? ai?iaaaeaeai? a iaa/aeueiee i?ioean ia eaoaae?? o??o?a?/ii?
noiiaoieia?? Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie o ?ic?iaeo iaoeiaeo ?acoeueoao?a. Aeena?oaoe?eia ?iaioa
? naiino?eiei cae?i/aiei iaoeiaei aeine?aeaeaiiyi. Aenia?eiaioaeueia
/anoeia ?iaioe aeeiiaia o a?aa??? Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo. A?noieia?/i? i?aia?aoe aeaioiaeai? ia eaoaae??
iaoieia?/ii? aiaoii?? EAeIO oa eiinoeueoiaai? caa?aeoaa/ai eaai?aoi???
i?iaeai inoaiaaiaco e.i.i. N??ei I.I. Ae?y o?ainieaioaoo in vitro
aea/aeany ia aac? a?aeae?eaiiy ?aaoeyoi?ieo nenoai ee?oeie ?inoeoooo
a?io?i?? ?i. I.A.Iaeeaae?ia Aeaaeai?? iaoe Oe?a?ie i?ae ea??aieoeoaii
e.a.i. Ei?/einueeiai I.A. Ee?i?/ia /anoeia ?iaioe aeeiiaia ia eaoaae??
o??o?a?/ii? noiiaoieia?? Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo, a a?aeae?e? uaeaiiai-eeoeaai? o??o?a?? Euea?anueei?
iaeanii? ee?i?/ii? e?ea?i?. Aeena?oaioii naiino?eii i?iaaaeaii ia?iaeo,
aiae?c oa ?ioa?i?aoaoe?th io?eiaieo ?acoeueoao?a aenia?eiaioaeueieo,
ee?i?/ieo, ee?i?ei-eaai?aoi?ieo ? ooieoe?iiaeueieo aeine?aeaeaiue.

Ai?iaaoe?y aeena?oaoe??. Iniiai? iieiaeaiiy oa iaoa??aee aeena?oaoe??
aeeeaaeai? ia: can?aeaiiyo Euea?anueeiai iaoeiaiai iaaee/iiai oiaa?enoaa
noiiaoieia?a (1994); ia iaoeia?e eiioa?aioe?? aiaoii?a, a?noieia?a,
aia??ieia?a ? oiiia?aoiaiaoii?a Oe?a?ie «Aeooaeuei? i?iaeaie
ooieoe?iiaeueii? aiaoii?? noaeeiii? nenoaie» (Euea?a, 1995); ia
I?aeia?iaei?e iaoeia?e eiioa?aioe?? «No/ani? i?iaeaie noiiaoieia??»
(Euea?a, 1996); ia i?aeia?iaeiiio nai?ia?? «Iia? iaoiaeeee oa oaoiieia??
a noiiaoieia??» (Euea?a, 1997).

Aeena?oaoe?eia ?iaioa ai?iaiaaia ia can?aeaii? eaoaae?e o??o?a?/ii?
noiiaoieia?? EAeIO, ia can?aeaii? I?iaeaiii? eii?n?? noiiaoieia?/iiai
oaeoeueoaoo EAeIO.

Ioae?eaoe??: ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 10 iaoeiaeo ?ia?o,
o oiio /ene? 4 noaoo? a ia??iaee/ieo aeaeaiiyo, 5 a ca??ieeao iaoeiaeo
i?aoeue, io?eiaii iaoaio ia aeiao?ae Oe?a?ie ? 23896A.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 170
noi??ieao iaoeiiieniiai oaenoo. Neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, 7-e ?icae?e?a iniiaii? /anoeie, aeniiae?a, nieneo
e?oa?aoo?e, aei yeiai aoiaeyoue 235 aeaea?ae, aeiaeaoeo. ?iaioa
?ethno?iaaia 77 ?enoieaie, 11 oaaeeoeyie, 4 a?ao?eaie.

INIIAIEE CI?NO

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

Aeeiiaiiy iinoaaeaieo caaaeaiue cae?enithaaeiny a ee?i?oe? i?e e?eoaaii?
60 oai?eo c iaoneeaaeiaieie o?aaiaoe/ieie ceaiaie ieaeiuei? uaeaie oa 18
oai?eo c oneeaaeiaieie ceaiaie ieaeiuei? uaeaie, ? a aenia?eiaio? ia 30
a?eeo uo?ao oa eoeueoo?? o?a?iaeano?a ethaeeie.

Aeey io?eiaiiy o?ainieaioaoo aeei?enoiaoaaee aeiaa? o?oa/ano? e?noee
14-15-aeaiieo eo?y/eo aia??ii?a. I?ney ?aoaeueiiai i/euaiiy a?ae i’yeeo
oeaiei, i?iaiaeeee ?o iaoai?/ia iiae??aiaiiy aei o?aaiaio?a ?ici??ii 1
ii3, o?i?/io (0,25% ?ic/eiii o?eineio) aeenioe?aoe?th oa eiioeaio?aoe?th
oeyoii oeaio?eooaoaaiiy i?e 1000 ia/oa ai?iaeiaae 5 oa. C iaoith
oieeiaiiy iiaeeeaiai ca?aaeaiiy i?eiieaciaie oa a??onaie, aeaiaoo?aoe??
oa?iieaa?eueieo a?ee?a, caeaoieo aeeeeeaoe aea?a?/i? ?aaeoe??, ia?iaeyee
ieanoe/iee iaoa??ae ia aiaeyi?e aai? i?e oaiia?aoo?? 56°N ai?iaeiaae 30
oa. Inaae ?anoniaiaeoaaee a eiina?aaio? «Aetha?oee?» o eiioeaio?aoe??
ee?oei 1,5?109 a 2-2,5 ie.

O oaeiio aeaeyae? o?ainieaioao caa??aaee o ia?ao?iiaaieo noa?eeueieo
oeaeiiao o ii?iceeuei?e eaia?? iiaooiaiai oieiaeeeueieea i?e oaiia?aoo??
-4-10°N (oa?i?i caa??aaiiy i?aeoe/ii iaiaiaaeaiee). I?e iaiao?aeiino?
o?ainieaioaoe?? noniaic?th AEEE ?icii?iaeoaaee ia aiaeyi?e aai? i?e
oaiia?aoo?? +40°N.

Aeey aecia/aiiy ?noeiii? ii?oieia?/ii? no?oeoo?e na?aeiaeae?eai?
aeenioe?eiaai? ee?oeie aen?aaee a iiaeeaiiio na?aaeiaeu? ?aea ia
eoeueoo?aeueiiio ieanoeeo i?e 37°N. I?e?ineii?/ia aeine?aeaeaiiy
i?iaiaeeee /a?ac 1 aeiao i?ney aen?aaiiy ee?oei. I?e oeueiio
niinoa??aaee cia/io e?euee?noue i?ee??ieaieo aei iiaa?oi? ee?oei
c??/anoi?, ceaaea aeaeiaaeaii? oi?ie, ye? i?noeyie iaaoaaee
iie?aiiaeueieo iciae, oa iacia/io e?euee?noue yaea?ieo ie?oaeeo ?
iaaeueieo ee?oeiieo aeaiaio?a, caaeneeo o iiaeeaiiio na?aaeiaeu?,
aeeoa?aioe?thaaoe ye? ia aaeaaaeiny.

Ia i?aenoaa? io?eiaieo aeaieo ae?eoee aeniiao, ui aeei?enoaiee iaie
o?ainieaioao ? noniaic??th aeaa?oae?ciaaieo oa?i?/iith ia?iaeith oa
caii?iaeoaaiiyi aia??iiaeueieo e?noeiaiiiceiaeo ee?oei, iiia?aaeiee?a
o?a?iaeano?a inoaiaaiiiai ?yaeo, io?eiaieo ?c o?oa/anoeo e?noie
14-aeaiieo eo?y/eo aia??ii?a.

?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue

Aeey c’ynoaaiiy iaoai?cio, yeee caaacia/o? iioei?cothth/ee aieea
enaiiaaiiiai aia??iiaeueiiai o?ainieaioaoo ia a?aeiiaethaaeuei? i?ioeane
o e?noeia?e oeaiei? aea/aee eiai aieea ia i?ie?oa?aoeaio aeoeai?noue
aia??iiaeueieo o?a?iaeano?a ethaeeie ca oiia eoeueoeaoaaiiy in vitro.
Aaeaea a?aeiii, ui naia ee?oeie o?a?iaeanoiiai ?yaeo ?
iiia?aaeieeaie inoaiaeano?a.

Aeine?aeaeaii caeaoi?noue o?ainieaioaoo ?i?oe?thaaoe i?ie?oa?aoe?th
ee?oei, yea aoea iiia?aaeiuei coieiaia oeyoii noai?aiiy aeao?oeeoo
oaeoi??a ?inoo, ui i?noyoueny o ne?iaaooe? e?ia? (?en. 1). Oae, i?ney
oaei? ia?iaee ?ioaineai?noue aeeth/aiiy o?eo?e-oei?aeeio o AeIE ee?oei
cieaeo?oueny o 2,2 ?ace (a?ae 38481±789 aei 16948±2291 ?ii/oa). I?ney
aeiaeaaaiiy o?ainieaioaoo aei eiai e?ioeaai? eiioeaio?aoe?? o
eoeueoo?aeueiiio na?aaeiaeu? 0,35% ia aeyaeaii aeinoia??iiai aieeao ia
?ioaineai?noue aeeth/aiiy ?aae?iaeoeaiiai iiia?aaeieea o AeIE ee?oei.
I?ioa, i?e ca?eueoaii? eiioeaio?aoe?? aei 1,0% niinoa??aaeiny c?inoaiiy
?ioaineaiino? aeeth/aiiy i?oee a?eueo i?ae o 4,7 ?ace. Aeiaeaaaiiy aei
eoeueoo?aeueiiai na?aaeiaeua o?ainieaioaoo aei eiai e?ioeaai?
eiioeaio?aoe?? 3,5% ?i?oe?th? c?inoaiiy aeeth/aiiy 3I-oei?aeeio iaeaea
o 8 ?ac?a. Ca?eueoaiiy eiioeaio?aoe?? i?aia?aoo o eoeueoo?aeueiiio
na?aaeiaeu? aei 10% i?ecaiaeeoue aei cieaeaiiy aoaeoeaiino? eiai
?inoiaeoea?cothth/iai aieeao (6,3 ?ace).

picscalex117010009000003281100000800180000000000050000000902000000000500
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7600040000002d010300040000002d010700040000002d010100040000002701ffff0300
00001e00040000002d010000040000002d010700040000002d010400050000000102ffff
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0400000004010d000400000002010200070000001804d400d900ce00d300040000002d01
0300040000002d010700040000002d010100040000002701ffff030000001e0004000000
2d010000040000002d010700040000002d010400050000000102ffffff00050000000902
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0400000002010200070000001804b3003601ad003001040000002d010300040000002d01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040000002d010000040000002d010700040000002d010400050000000102ffffff000500
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04010d000400000002010200070000001804c900d900c300d300040000002d0103000400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050000000102ffffff0005000000090200000000070000001604ea00f2011b0075000500
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ea01040000002d010300040000002d010700040000002d010100040000002701ffff0300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3030303009000900090009000900090010000000320a1500360006000000313430303030
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0400050000000102ffffff00050000000902000000000700000016048901170200000000
040000002d010300040000002d010700040000002d010100040000002701ffff03000000
1e00040000002d010000040000002d010700040000002d010400050000000102ffffff00
050000000902000000000700000016048a011802ffffffff0400000004010d0004000000
020101000a000000320af5006d00020000003025090010000f000000320af500be000500
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10000d000000320af5007d0104000000332c352509000500090010000f000000320af500
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0700040000002d010100040000002701ffff030000001e00040000002d01000004000000
2d010700040000002d010400050000000102ffffff000500000009020000000007000000
16048901170200000000040000002d010000040000002d010000040000002d0103000400
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040000002d010700040000002d010400050000000102ffffff0005000000090200000000
0700000016049f00340066000f000400000004010d00040000000201010015000000fb02
edff0000840384039001000000cc0010001254696d6573204e657720526f6d616e00cc00
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cc0118016600040000002d010300040000002d010700040000002d010100040000002701
ffff030000001e00040000002d010000040000002d010700040000002d01040005000000
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030000000000

?en.1 Caeaaei?noue ?ioaineaiino? ?inoo ee?oei a?ae eiioeaio?aoe?? oa
aeaeo ia?iaee o?ainieaioaoo i?ney coieiee ?o i?ie?oa?aoe??.

Io?eiaiee i?ney oa?i?/ii? ia?iaee i?aia?ao, ye ? i?aia?ao aac oa?i?/ii?
ia?iaee, ia cae?enithaaa aeinoia??iiai aieeao ia ?ioaineai?noue
aeeth/aiiy 3I-oei?aeeio ca eiioeaio?aoe?? 0,35%, a aaea i?e
eiioeaio?aoe?? 1,0% aeoea?coaaa aeeth/aiiy i?oee o AeIE ee?oei o 2,2
?ace. Ca?eueoaiiy eiioeaio?aoe?? oa?i?/ii ia?iaeaiiai o?ainieaioaoo aei
3,5% ? 10% aaaea aei c?inoaiiy aeeth/aiiy 3I-oei?aeeio a?aeiia?aeii o
3,3 oa 5,5 ?ace.

Aeey iioei?coth/iai aieeao ia caai?iiy iioeiaeaeaiue e?noie aaaeeeai ia
o?eueee ?i?oe?thaaoe i?ie?oa?aoe?th ee?oei, aea e aeoea?coaaoe
?ioaineai?noue ?inoo ee?oei, ui ?ioaineaii i?ie?oa?othoue. Aeey oeueiai
ie aiineee o?ainieaioao aei eoeueoo?aeueiiai na?aaeiaeua, a yeiio
ee?oeie ia?aaoaaee a oiiaao eiaa?eoi?/ii? oace ?inoo. I?e oeueiio
anoaiiaeaii, ui aeine?aeaeoaaiee o?ainieaioao ca eiioeaio?aoe?? 1% oa
3,5% noeioeth? aeeth/aiiy 3I-oei?aeeio o AeIE ee?oei a?aeiia?aeii o 2,1
oa 1,8 ?aco (?en. 2). Ca?eueoaiiy eiioeaio?aoe?? aei 10% i?ecaiaeeoue
aei cieaeaiiy aoaeoeaiino? eiai ?inoinoeioethth/iai aieeao. sse ? i?e
aeine?aeaeaii? caeaoiino? o?ainieaioaoo ?i?oe?thaaoe i?ie?oa?aoe?th
ee?oei, eiai oa?i?/ia ia?iaea cieaeo? ?inoinoeioethth/o aeoeai?noue.
Ioaea, aeine?aeaeoaaiee iaie o?ainieaioao ? oaeiae, oi/a ? iaioith
i??ith, aeinoaoiuei aoaeoeaiei aeoeaaoi?ii ?inoo ee?oei, ye? ?ioaineaii
i?ie?oa?othoue.

Aeey aea/aiiy ?icaeoeo e?noeiai? oeaieie aeei?enoaee iiaeaeue
?iaeoeiaaiiai aeoii?/iiai inoaiaaiaco. Aecia/aiiy inoai?iaeoeoeaieo
aeanoeainoae noniaic?? AEEE i?iaiaeeee ia 10 eiiaaioe?eieo a?eeo
uo?ao-naioeyo ianith 150-250 a. O?ainieaioaoe?th aeeiioaaee i?ae
aeii/a?aaaiiei ia?eicii ?i’?eoe?eiei iaoiaeii: ioieoe?eiith aieeith
aaiaeeee a?ey 0,5-0,6 ie noniaic?? AEEE i?aeoe??ii a ae?eyioe?
aioo??oiuei? iiaa?oi? noaaia iaio eaiie uo??a. Oa?i?ie niinoa?aaeaiiy
noaiiaeee 7, 14, 21, 30, 60, 90, 180 aei?a.

A?noieia?/ii ia 7-14 aeaiue a cacia/aieo ae?eyieao o?ainieaioaoe??
niinoa??aaeeny aiaieua aeoii?/iiai inoaiaaiaco c ?yniith
aaneoey?ecaoe??th oa ?ioaineaiith i?ie?oa?aoe??th ee?oeiieo aeaiaio?a. O
iiaeaeueo? oa?i?ie (14-21 aeaiue) a?aeaoaaeiny oi?ioaaiiy o?a?icii?
eainoee aiaieua aeoii?/iiai inoaiaaiaco, aeoea?coaaeeny i?ie?oa?aoeai?
i?ioeane inoaiaeanoe/ieo no?oeoo?.

picscalex114010009000003b20f00000800180000000000050000000902000000000500
00000102ffffff000400000004010d000400000002010200050000000c02830110020300
00001e00040000002701ffff030000001e00040000002701ffff050000000b0200000000
030000001e00050000000102ffffff000500000009020000000015000000fb02edff0000
000000009001000000cc0000001254696d6573204e657720526f6d616e00cc0004000000
2d010000040000002d010000040000002d01000010000000fb021000070000000000bc02
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1e00040000002d010000050000000102ffffff0005000000090200000000070000001604
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0000050000000102ffffff00050000000902000000000700000016048301100200000000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ff00050000000902000000000700000016047f010c0204000400040000002d0103000400
00002d010100040000002701ffff030000001e00040000002d010000040000002d010200
050000000102ffffff0005000000090200000000070000001604f900f0011b0075000400
00002d010300040000002d010100040000002701ffff030000001e00040000002d010000
040000002d010200050000000102ffffff0005000000090200000000070000001604f600
f0011b00750007000000fc020100000000008020040000002d01040009000000fa020500
00000000ffffff002200040000002d01050004000000f0010200050000001402a0007900
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7c00a0007800a1000500000014029f007c000500000014029d0084000c00000024030400
83009c0087009b0088009d0084009e000500000014029c00880005000000140299008f00
0c000000240304008e00980092009700930099008f009a00050000001402980093000500
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7e00f6007f00f7007d00f3007c000500000014027e00f7000500000014027f00ff000c00
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82000f01050000001402830017010c00000024030400160184001a0185001b0183001701
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04002e01880031018900320187002f018600050000001402880032010500000014028900
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14029300710105000000140293007001040000002d010200040000002d01040005000000
14029300700105000000140293006f01040000002d010500040000002d0102000c000000
240304006e01940072019500730193006f01920005000000140294007301050000001402
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7f01050000001402990086010c0000002403040085019a0089019b008a01990086019800
0500000014029a008a010500000014029c0092010c0000002403040091019d0095019e00
96019c0092019b000500000014029d0096010500000014029f009e010c00000024030400
9d01a000a001a100a1019f009e019e00050000001402a000a101050000001402a200a901
0c00000024030400a801a300ac01a400ad01a200a901a100050000001402a300ad010500
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1402a600b901050000001402a800c0010c00000024030400bf01a900c301ab00c401a900
c001a700050000001402aa00c401050000001402ac00cc010c00000024030400cb01ad00
cf01ae00d001ac00cc01ab00050000001402ad00d001050000001402af00d8010c000000
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5000f400040000002d010200040000002d0104000500000014025000f400050000001402
5000f300040000002d010500040000002d0102000c00000024030400f200510000015300
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8900c00183000500000014028a00cd010500000014028d00d4010c00000024030400d301
8e00e0019400e1019200d4018c000500000014029300e1010500000014029600e8010c00
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14029800eb01040000002d010200040000002d01040009000000fa020000020000000000
00002200040000002d010600050000001402a0007900050000001302a000f40005000000
1402a000f400050000001302a0007001050000001402a0007001050000001302a000eb01
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2d010100040000002701ffff030000001e00040000002d010000040000002d0107000400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000007000000160484011102ffffffff0400000004010d00040000000201010009000000
320ae700630001000000300009000f000000320abd003f00050000003230303030000900
09000900090009000f000000320a93003f00050000003430303030000900090009000900
09000f000000320a69003f0005000000363030303000090009000900090009000f000000
320a3f003f00050000003830303030000900090009000900090010000000320a15003600
06000000313030303030090009000900090009000900040000002d010300040000002d01
0700040000002d010100040000002701ffff030000001e00040000002d01000004000000
2d010700040000002d010400050000000102ffffff000500000009020000000007000000
16048301100200000000040000002d010300040000002d010700040000002d0101000400
00002701ffff030000001e00040000002d010000040000002d010700040000002d010400
050000000102ffffff000500000009020000000007000000160484011102ffffffff0400
000004010d0004000000020101000a000000320a01016d00020000003025090010000a00
0000320a0101e800020000003125090010000d000000320a01015d0104000000332c3525
09000500090010000c000000320a0101da01030000003130250009000900100004000000
2d010300040000002d010700040000002d010100040000002701ffff030000001e000400
00002d010000040000002d010700040000002d010400050000000102ffffff0005000000
0902000000000700000016048301100200000000040000002d010000040000002d010000
040000002d010300040000002d010700040000002d010100040000002701ffff03000000
1e00040000002d010000040000002d010700040000002d010400050000000102ffffff00
05000000090200000000070000001604a50034006c000f000400000004010d0004000000
0201010015000000fb02edff0000840384039001000000cc0010001254696d6573204e65
7720526f6d616e00cc00040000002d0106000a000000320aa100170006000000b3ecef2f
f5e2040000002d01000004000000f0010600040000002d010000040000002d0103000400
00002d010700040000002d010100040000002701ffff030000001e00040000002d010000
040000002d010700040000002d010400050000000102ffffff0005000000090200000000
070000001604830110020000000009000000fa0205000000000000000000220004000000
2d01060004000000f0010400040000002d010300040000002d010700040000002d010100
040000002701ffff030000001e00040000002d010000040000002d010700040000002d01
0600050000000102ffffff00050000000902000000000700000016047601c70126016b00
040000002d010300040000002d010700040000002d010100040000002701ffff03000000
1e00040000002d010000040000002d010700040000002d010600050000000102ffffff00
050000000902000000000700000016047601c70126016b00040000002d01050004000000
f00106000500000014023501720005000000140235017100040000002d01050004000000
2d0102000400000004010d0004000000020101000c000000240304007100340175003401
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7d00340181003401810036017d0036010500000014023501810005000000140235018900
0c00000024030400890034018d0034018d0036018900360105000000140235018d000500
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14023501990005000000140235019b0005000000140235019a00040000002d0102000400
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040000002e01180017000000320a3b019e0020000000f2e5f0ecb3f7edee20eee1f0eee1
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2d0107000500000014024f018600040000002d01070009000000fa020000010000000000
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2d010700040000002d010400050000000102ffffff000500000009020000000007000000
16047601c70126016b0009000000fa02000002000000000000002200040000002d010600
04000000f0010400050000001402690172000400000004010d0004000000020101000500
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08000000eaeeedf2f0eeebfc040000002e010000040000002d010300040000002d010700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?en.2 Caeaaei?noue ?ioaineaiino? iioaioe?? aia??iiaeueieo o?a?iaeano?a
ethaeeie, ye? ia?aaoaathoue o eiaa?eoi?/i?e oac? ?inoo, a?ae
eiioeaio?aoe?? oa aeaeo ia?iaee o?ainieaioaoo.

Oa?i?ie 30-60 aei?a oa?aeoa?ecoaaeeny ae?aaeaiith ?ioaineaiith
i?ie?oa?aoe??th oa ao?oeeaei ?icaeoeii inoai?aeii? aeeoa?aioe?aoe??
ee?oeiieo aeaiaio?a. Ia 60-90 aeaiue niinoa?aaeaiiy aeyaeaii ooai?aiiy
oyae?a inoaiaeanoe/ieo oa o?a?iaeanoe/ieo ee?oeiieo no?oeoo?, ui
i?noeyie iaae?aee iicaeiaaeiueiai iie?aiiaeueiiai ni?yioaaiiy ?
oi?ioaaeeny a o?a?iaeanoe/iee inoai?ae. Aei 90-ai aeiy a 30-40%
aeine?aeieo niinoa?aaeaiue aeoii?/iiai inoaiaaiaco aeyaeaii noi?iiaai?
aaeeia? no?oeoo?e aoa/anoi? e?noeiai? oeaieie.

Aenia?eiaioaeueia aeine?aeaeaiiy aieeao o?ainieaioaoe?? AEEE ia i?ioeane
caai?iiy e?noeiai? ?aie i?iaiaeeeiny ia 20 eiiaaioe?eieo a?eeo
uo?ao-naioeyo ianith 150-250 a. Iane??ciee aeaoaeo ae?aiao?ii 2,0 ii
noai?thaaee a ieaei?e o?aoei? a?eee ieaeiuei? uaeaie oaa?eie aeeae/a aei
?? caaeiueiai e?ath. Aiaeia?/iee aeaoaeo ?iaeee c i?ioeeaaeii? noi?iie.
E?noeiao ?aio ni?aaa caiiaithaaee caaennth AEEE, c i?ioeeaaeii? noi?iie
aiia naiia?eueii aeiiaithaaeany e?ia’yiei caonoeii. ?aie i’yeeo oeaiei
iioa?iai caoeaaee.

Iia?aoeaia ao?o/aiiy i?aeoe/ii an? oaa?eie ia?aiineee aeia?a, eaaei
aeoiaeeee ?c ia?eico, /a?ac 3 aiaeeie a?aeiiaethaaee aeoeai?noue, ioi/a
i?eeiaee ?aeo. Cae/i?, oa?aeoa?i? aeey aeaii? o?aaie caiaeuei? yaeua
cieeaee iaeiaeiai c iaio noi??i ia 3-4 aeaiue. I?neyiia?aoe?ei? ?aie
ai?eeny ia?aeiiei iaoyaii.

Oaa?ei aeaiaeeee c aeine?aeo ia 3, 7, 14, 21, 30, 60, 90, 180 aeiao.
Ieaei? uaeaie aeae?eyee c iaaeieeoi?ie i’yeeie oeaieiaie, o?enoaaee a
10% iaeo?aeueiiio ?ic/ei? oi?iae?io. ?aioaaiieia?/ia aeine?aeaeaiiy
i?iaiaeeee eiioaeoiei niiniaii, ii?oieia?/i? ianoaaeaiiy cae?enithaaeeny
iaoiaeaie noaiaea?oii? a?noieia??.

Aiae?c io?eiaieo ?aioaaiieia?/ieo aeaieo iieacaa, ui o ia?o? aei?
niinoa?aaeaiiy ua ia a?aecia/aee cia/ieo a?aei?iiinoae i?ae i?ioeanaie
?aaaia?aoe?? a eiio?ieueieo oa aeine?aeieo aeiaaeeao. ?aioaaiieia?/ia
ea?oeia o oa?i?ie 7 aei?a i?aeoe/ii ?aeaioe/ia, aeaoaeoe aiiiaaiii
eiio?anoiaai?, c /?oeeie e?ayie.

I?ioa aaea o ianooii? oa?i?ie (14 aei?a) niinoa??aaeeny a?aei?iiino? a
ia?aa?ao ?aia?aoeaieo i?ioean?a: o aeine?aeieo aeiaaeeao aecia/aeany
caaoaeueiaai?noue aeaoaeoo, e?a? yeiai caeaaeaeoaaeeny oa ao?a/aee
/?oe?noue. Oe? ae i?iyae o eiio?ie? aoee ae?aaeai? neaaoa. Oaea ae
?aioaaiieia?/ia ea?oeia c a?eueo /?oeei eiio?anooaaiiyi aecia/aeany a
aeine?ae? o iiaeaeueo? oa?i?ie niinoa?aaeaiiy (21 oa 30 aei?a).

Iiceoeaia aeeiai?ea a?eueo ?ioaineaiiai ooai?aiiy e?noeiai-oeaieiiiai
?aaaia?aoo caa??aaeany ? iaaeae?. sseui o aeine?aeieo aeiaaeeao aaea ia
90 aeiao i?ney o?aaie aecia/eoe iaae? aeaoaeoo aoei aeineoue aaaeei, a
ia 180 aeaiue aaea iaiiaeeeai ? a?aecia/aeiny iiaia a?aeiiaeaiiy
ao?a/aii? e?noee, oi o eiio?ie? o?iue ioai??a aeaoaeoo ie?oaei? oi?ie
aecia/aeany iaa?oue ia ?aioaaiia?aiao e?ioeaaiai oa?i?io niinoa?aaeaiiy
(180 aeiaa).

Io?eiai? ?acoeueoaoe ii?oieia?/ieo aeine?aeaeaiue, ye ? ?aioaaiieia?/i?
aeai?, i?aeoaa?aeaeothoue iiceoeaiee iioei?coth/ee aieea o?ainieaioaoe??
noniaic?? AEEE ia i?ioeane ?aia?aoeaii? ?aaaia?aoe?? a e?noeiaeo
aeaoaeoao.

Ia a?aei?io a?ae eiio?ieueieo niinoa?aaeaiue, o aeine?ae? i?ioeane
inoai?aaaia?aoe?? i?ioiaeyoue cia/ii oaeaeoa aiane?aeie ?ioaineai?oi?
i?ie?oa?aoe?? oa aeeoa?aioe?aoe?? inoaiaaiieo ee?oeiieo aeaiaio?a o
ia??iae i?ae 3-7 aeiai i?ney iia?aoe??, ?aiiueiai i?i?inoaiiy
i?e?inoaeei o ciio e?noeiaiai aeaoaeoo, ui o e?ioeaaiio ?acoeueoao?
nei?i/o? oa?i?ie caai?iiy e?noeiai? ?aie.

Aaea /a?ac i?nyoeue i?ney o?aaie e?noee a ae?eyioe? aeaoaeoo
niinoa??aaeany ?ioaineaii eaeueoeeo?eiaaia iiaiooai?aia e?noeiaa oeaieia
inoaiiii? aoaeiae. *a?ac o?noue i?nyoe?a e?noeiaa oeaieia ia i?noe?
aeaoaeoo iaea cae/io aoaeiao ? ia a?ae??ciyeany a?ae noi?aeieo ae?eyiie.
?aioaaiieia?/ii a oe? oa?i?ie ciia eieeoiuei? o?aaie ia aeae?ey?oueny.

Aiaeii/an o eiio?ieueieo niinoa?aaeaiiyo no?oeoo?a e?noeiai-oeaieiiiai
?aaaia?aoo iaio aeeoa?aioe?eiaaia, ei?oeeaeueia oa aoa/anoa ?a/iaeia
ia?aaoaa? o oac? i?aaiii? ia?aaoaeiae, oiaoi aoi?eii? i?ioeane
?aia?aoeaiiai inoaiaaiaco i?ioiaeyoue ia 2-3 i?nyoe? i?ci?oa. Ia
?aioaaiia?aiao eiio?ieueii? a?oie oaa?ei o oa?i?ie niinoa?aaeaiiy 6
i?nyoe?a ciia aeaoaeoo ua caeeoaeanue iii?oiith.

Oaeee iiceoeaiee aieea noniaic?? AEEE aecia/a?oueny ai?noii
a?ieia?/ii-aeoeaieo ?a/iaei, ui aieeaathoue ia iie?iioaioi?
iacaio?iaeuei? ee?oeie ia??inoo oa aiaeinoo, ni?eythoue ?o
aeeoa?aioe?aoe?? a aiaeioae?ioeeoe, ye? aenoaeythoue noaeeie oa a
inoaiaeanoe, ye? i?iaeoeothoue e?noeiao oeaieio. sse iane?aeie,
i?ioiaeeoue oaeaeoa a?aeiiaeaiiy e?noeiai? oeaieie aac i?ii?aeii? oace
oiiae?i?aeii? iaoaieac??.

?acoeueoaoe ee?i?/ieo aeine?aeaeaiue

Io?eiai? iiceoeai? aenia?eiaioaeuei? ?acoeueoaoe aeicaieeee canoinoaaoe
o?ainieaioaoe?th noniaic?? AEEE i?e e?eoaaii? oe?iei ?iciianthaeaeaieo o
ee?i?oe? uaeaiiai-eeoeaai? o??o?a?? caoai?thaaiue: ceai?a ieaeiuei?
uaeaie oa ?o iae/ano?oeo oneeaaeiaiue — niia?eueiaii? eiinie?aeaoe?? oa
iino?aaiaoe/ieo inoaii??e?o?a.

O?ainieaioaoe?th i?iaiaeeee ?i’?eoe?eiei, ye i?aaeei, aioo??oiuei?ioiaei
iaoiaeii i?ney i?oiiaaee/ii? ?iiia?e?caoe?? a?aeeaie?a ieaeiuei? uaeaie
ca aeiiiiiaith iacoaieo oei ?c ca/?iieie iaoeyie oa aeanoe/ieo
i?aeuaeaiiaeo oya. E??i canoinoaaiiy ee?oeiii? enaiia?aoio?ainieaioaoe??
a iniiai?e a?oi? oai?eo, ?ioeo, a?aei?iieo a?ae eiio?ieueii? a?oie,
iaoiae?a aieeao ia i?ioeane eiinie?aeaoe?? ceaio ia aeei?enoiaoaaee.

Aiae?c ee?i?/ieo aeiaaee?a iieacaa, ui i?e o?ainieaioaoe?? noniaic??
AEEE niinoa??aa?oueny oaiaeaioe?y aei aeoeai?oiai ia?aa?ao
eiinie?aeaoe?? a?aeeaie?a ieaeiuei? uaeaie, a?aeiiaeaiiy e?noee
i?io?eaei a?eueo ni?eyoeeai, i?ioean e?eoaaiiy oai?eie ia?aiineany eaaoa
ii??aiyii c oai?eie, yeei ia i?iaiaeeeany enaiia?aoio?ainieaioaoe?y. O
ia?o? aei? e?eoaaiiy a oai?eo iniiaii? oa eiio?ieueii? a?oie ae?aaeaieo
a?aei?iiinoae a ee?i?/iiio ia?aa?ao ia aeyaeaii. Eeoa a iiiaeeiieeo
aeiaaeeao, o oai?eo a?ia?a?a?/iiai oeio i?ney o?ainieaioaoe??
a?aecia/aeany iacia/ia aieueiaa ?aaeoe?y ai?iaeiaae ia?oiai aeiy, a
iiaeaeueoiio — noao?a?eeueia i?aeaeuaiiy oaiia?aoo?e o?ea, ca?eueoaiiy
iaa?yeo ioi/oth/eo i’yeeo oeaiei oa ?aa?iia?ieo e?ioaoe/ieo aoce?a.
I?ioa aeacai? yaeua i?e a?aeiia?aeiiio, iaeiaeiaiio e?eoaaii? ye a
iniiai?e, oae ? a eiio?ieuei?e a?oiao, cieeaee ia 5-6 aeaiue, eeoea
iaaoaaei cae/ii? neiao?e/iino?, ia neecia?e iaieiioe? aeueaaiey?iiai
a?ae?inoea yaeua a?ia?ai?? oa ?io?eueo?aoe?? ia niinoa??aaeeny.

A aaea ia 10-13 aeaiue a?ae iiiaioo ?aiiceoe?? oa o?enaoe?? a?aeeaie?a o
aeine?aei?e a?oi? oai?eo i?e iaeueiaoe?? aeyaeyeinue iioiauaiiy e?noee
oa iciaee oi?ioaaiiy ia?aeiiiai e?noeiaiai iiciey. Aeacai? ee?i?/i?
i?iyae a eiio?ieuei?e a?oi? oai?eo c’yaeyeenue eeoa ia 15-17 aeaiue, ?o
ae?aaeai?noue aoea cia/ii iaioith.

A?aenooi?noue ?ooiiino? a?aeeaie?a, caiaeueieo iciae o ae?eyioe? ceaio,
a?aeiiaeaiiy aiaoii?/ii? oi?ie aeicaieeei iai i?eieiyoe i?aeuaeaiiao
?iiia?e?caoe?th ia 19-20 aeaiue i?e iaeiia?/ieo ceaiao oa ia 21-22
aeaiue i?e aeaia?/ieo. Oe? ae oa?i?ie a eiio?ieuei?e a?oi? noaiiaeee
a?aeiia?aeii 22-24 aei? oa 24-26 aei?a.

Iao? ee?i?/i? niinoa?aaeaiiy ca i?ioeanaie caai?iiy ceai?a ieaeiuei?
uaeaie a iaio a?oiao oai?eo ei?aeththoue c aeaieie ?aioaaiieia?/iiai
ianoaaeaiiy. Ia iiiaio i?eieiaiiy i?aeuaeaiiai? ?iiia?e?caoe?? a
aeine?aei?e a?oi? oai?eo ?aioaaiieia?/ii niinoa??aaeeny ae?aaeai? iciaee
eiinie?aeaoe?? ceai?a ieaeiuei? uaeaie. sseui o eiio?ieuei?e a?oi?
a?aecia/aeeny ?ioaineaii ae?aaeai? i?ioeane e?aeiaiai inoaiii?ico
e?noeiaeo a?aeeaie?a, ?o ia/?oe?noue oa ?icieea/ano?noue, ?icoe?aiiy
u?eeie ceaio e?noee, aea niinoa??aaeanue i?aeia aoaeue e?noeiaiai
iiciey, oi o iniiai?e a?oi? i?iyae ?a?ao?eaoe?? aoee ae?aaeai? iaioa,
e?noeia? e?a? a?aeeaie?a caeaaeaeai?, caoaeaia u?eeia ceaio c iii?oii
aonoith o?iith ia?aeiiiai e?noeiaiai iiciey.

A?eueo ni?eyoeeaee ee?i?/iee ia?aa?a o iniiai?e a?oi?, ii??aiyii c
eiio?ieueiith, aieeioa ia oa?i?ie e?eoaaiiy oai?eo oa a?aeiiaeaiiy ?o
i?aoeacaeaoiino?. ??cieoey a o?eaaeino? e?eoaaiiy a na?aaeiueiio
noaiiaeea 4-5 aei?a.

Aoaeoeai?noue aeei?enoaiiy ee?oeiii? enaiia?aoio?ainieaioaoe?? a
eiiieaeniiio e?eoaaii? ceai?a ieaeiuei? uaeaie i?aeoaa?aeeee
aoiinoaiiao?e/i? aeine?aeaeaiiy ciie iioeiaeaeaiiy e?noeiai? oeaieie a
a?eueo ?aii? oa?i?ie, i?ae ee?i?/i? oa ?aioaaiieia?/i? aeaieie.
Aoiinoaiiao??th i?iaiaeeee iaoiaeii aaniethoiiai aei??thaaiiy ia 7, 14,
21, 30 aei? e?eoaaiiy.

Io?eiai? iieacieee aoiinoaiiao??? iiai?noth ei?aeththoue ?c
ee?i?ei-?aioaaiieia?/ieie aeaieie (?en. 3). O ia?o? aei? e?eoaaiiy
cia/ii? ??cieoe? a ia?aa?ao i?ioean?a inoai?aaaia?aoe?? ca iieacieeaie
i?ioiaeaeaiiy oeueo?acaoeiai? oaee? ia a?aecia/aee. O iniiai?e a?oi?
oaeaee?noue ?iciianthaeaeaiiy oeueo?acaoeo noaiiaeea 2844±25 i/n (86%
a?ae iieacieea ii?ie), a a eiio?ieuei?e a?aeiia?aeii — 2810±34 i/n (85%
ii?ie). Aea, ii/eiath/e c 10-12 aeiy, niinoa??aaeiny ??cea c?inoaiiy
oaeaeeino? ?iciianthaeaeaiiy oeueo?acaoeiai? oaee? ii e?noeia?e oeaiei?,
yea a iniiai?e a?oi? noaiiaeea 3009±37 i/n (91% ii?ie), a eiio?ieuei?e —
2910±34 i/n (88% ii?ie). Oe? aeai? na?ae/aoue i?i ?ioaineo?eaoe?th
a?aeiiaieo i?ioean?a oa ca?eueoaiiy u?eueiino? oeaiei o ae?eyioe?
iioeiaeaeaii? e?noee. Oaea iiceoeaia aeeiai?ea a?aecia/aeany ? a
ianooii? oa?i?ie niinoa?aaeaiiy: ia 21 aeiao e?eoaaiiy a iniiai?e a?oi?
iieacieee oaeaeeino? ?iciianthaeaeaiiy oeueo?acaoeo noaiiaeee 3108±58
i/n (94% ii?ie), a eiio?ieuei?e — 2976±30 i/n (90% ii?ie); ia 30 aeiao
a?aeiia?aeii — 3207±49 i/n (97%ii?ie) oa 3076±51 i/n (93% ii?ie).

Caaaeath/e ia a?aeiinio /anoioo oaeiai oneeaaeiaiiy ye niia?eueiaia
eiinie?aeaoe?y, yea aeiaaa?, caeaa?eueoiai, iia?aoeaiiai ao?o/aiiy, oa
a?aoiaoth/e aenie? aeoeaoth/? inoai?aaaia?aoeai? aeanoeaino? noniaic??
AEEE, iaie cai?iiiiiaaii niin?a e?eoaaiiy ceai?a ieaeiuei? uaeaie ?c
niia?eueiaiith eiinie?aeaoe??th, iniiao yeiai noaiiaeoue ?i’?eoe?eia
o?ainieaioaoe?y noniaic?? AEEE a i?aeo?aaiaioa?io ae?eyieo iioeiaeaeaii?
e?noee. O?ainieaioaoe?th i?iaiaeeee oai?ei c iacia/ieie u?eeiiiiae?aieie
aeaoaeoaie ieaeiuei? uaeaie, ye? aeieeaee i?ney naeaano?aeoii??,
coiiaeaii? o?aaiaoe/iei inoaii??e?oii, oa oai?ei, o yeeo, iacaaaeath/e
ia ?iiia?e?caoe?th a?aeeaie?a eiinie?aeaoe?y, ia ianooiaea /a?ac 40-50
aei?a.

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02010200070000001804b4000a01ae000401040000002d010400040000002d0108000400
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040000002d010500050000000102ffffff00050000000902000000000700000016041e01
c80111004600050000001402970065010400000004010d00040000000201020007000000
18049a00680194006201040000002d010400040000002d010800040000002d0102000400
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050000000102ffffff00050000000902000000000700000016041e01c801110046000500
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c001040000002d010400040000002d010800040000002d010200040000002701ffff0300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00002d010400040000002d010800040000002d010200040000002701ffff030000001e00
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14021500a80005000000140215000701050000001402150065010500000014021500c301
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1e00040000002d010000040000002d010800040000002d010500050000000102ffffff00
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2d010800040000002d010200040000002701ffff030000001e00040000002d0100000400
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040000002d010100040000002d010100040000002d010100040000002d01040004000000
2d010800040000002d010200040000002701ffff030000001e00040000002d0101000400
00002d010800040000002d010500050000000102ffffff00050000000902000000000700
0000160405017e00e00050000400000004010d0004000000020101000c000000320ae900
540003000000383325000a000a000f00040000002d010100040000002d01040004000000
2d010800040000002d010200040000002701ffff030000001e00040000002d0101000400
00002d010800040000002d010500050000000102ffffff00050000000902000000000700
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040000002d010800040000002d010200040000002701ffff030000001e00040000002d01
0100040000002d010800040000002d010500050000000102ffffff000500000009020000
0000070000001604eb00dc00c600ae000400000004010d0004000000020101000c000000
320acf00b20003000000383525000a000a000f00040000002d010100040000002d010400
040000002d010800040000002d010200040000002701ffff030000001e00040000002d01
0100040000002d010800040000002d010500050000000102ffffff000500000009020000
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2d010400040000002d010800040000002d010200040000002701ffff030000001e000400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?en.3 I?ioeaioia ni?aa?aeiioaiiy iieaciee?a aoiinoaiiao??? o iniiai?e oa
eiio?ieuei?e a?oiao. Ca iieaciee ii?ie (100%) i?eeiyoi oaeaee?noue
i?ioiaeaeaiiy oeueo?acaoeiai? oaee? ii iaooeiaeaeai?e ieaei?e uaeai?.

An?i oai?ei, ye? ia?aianee naeaano?aeoii?th, i?iaiaeeee ?aioaaiieia?/ia
aeine?aeaeaiiy. sse i?aaeei, ia i?noe? aeaeaeaieo naeaano??a aeyaeyee
aeaoaeo e?noeiai? oeaieie. I?ney ciyooy eieaeueieo i?neyiia?aoe?eieo
caiaeueieo yaeu (ciaioaiiy iaa?yeo i’yeeo oeaiei), i?ae i?noeaaei
ciaaieaiiyi ?i’?eoe?eii oai?ei aaiaeeee caeaaeii a?ae ia’?io aeaoaeoo
e?noee 2-4 ie noniaic?th AEEE. Cia/ieo oneeaaeiaiue aiane?aeie
o?ainieaioaoe?? ia niinoa??aaeiny. Iiaeaeueoa e?eoaaiiy i?iaiaeeee ca
o?aaeeoe?eiith iaoiaeeeith. *a?ac aeaa oeaei? c’yaeyeenue iciaee
ooai?aiiy e?noeiaiai iiciey, ia 3-4 oeaeaeaiue a?aei?/aii no?eeo
eiinie?aeaoe?th a?aeeaie?a o ia?aaaaeii? a?eueoino? oai?eo.
?aioaaiieia?/ii a u?eei? ceaio aaea ia 12-14 aeaiue
i?neyo?ainieaioaoe?eiiai ia??iaeo niinoa??aaee ?ioaineaio aoaeue, yea
na?ae/eea i?i ii/aoeia? i?ioeane i?ia?ae?caoe?? e?noeiaiai iiciey. *a?ac
6 i?n. no?oeoo?a e?noeiai? oeaieie o ae?eyioe? inoaii??e?oe/iiai
i?ioeano iaeaea a?ae??ciyeany a?ae noi?aeieo ae?eyiie, i?noeyie
aeyaeyeenue ae?eyiee inoaineea?ico, ui na?ae/eoue i?i i?iaeiaaeaiiy
i?ioean?a ia?aaoaeiae iiciey.

On?i oai?ei ?c niia?eueiaiith eiinie?aeaoe??th i?iaiaeeee ei?aeoe?th
?iiia?e?caoe??. O?ainieaioaoe?y o oaeeo aeiaaeeao aeiaaaea cia/ieo
coneeue /a?ac iayai?noue a i?aeo?aaiaioa?i?e ae?eyioe? u?eueii?
o?a?icii? oa o?yuiai? oeaieie. Aeey iieaaoaiiy o?ainieaioaoe?? ?iaeee
e?eueea eieeaaeueieo ?oo?a oi?eoeii, ?oeioth/e /anoeio o?a?iciiai ?
o?yuiaiai iiciey oa noai?thth/e «ni?eeiath/o» ciio. O?ainieaioao
aaiaeeany i?ae iaaiei oeneii. I?ney cieeiaiiy iino?aaiaoe/ii?
neiioiiaoeee, iiaeaeueoee ia?aa?a ia aoa oneeaaeiaiei. Ia 12-14 aeaiue
niinoa??aaeiny iioiauaiiy e?noeiai? oeaieie a iaoieia?/i?e ae?eyioe? aac
caiaeueieo i?iya?a, ui na?ae/eei i?i ?ioaineaia ooai?aiiy ia?aeiiiai
e?noeiaiai iiciey. Ia 20-22 aeaiue a?aecia/aeany no?eea eiinie?aeaoe?y
a?aeeaie?a. ?aioaaiieia?/ii aeyaeai? iciaee i?ia?ae?caoe?? ciie ceaio:
e?a? a?aeeaie?a noaaaee iaio /?oeeie, caeaaeaeaieie, i?ae ieie
niinoa??aaeany ae?aaeaia caaoaeueiaai?noue. I?e eiio?ieueieo iaeyaeao
/a?ac i’youe-o?noue i?nyoe?a i?ney o?aaie aeiaeieo ee?i?/ieo iciae ia
aeyaeaii. ?aioaaiieia?/ia ea?oeia o?aaiiaaii? ae?eyiee ia a?ae??ciyeany
a?ae ioi/oth/eo oeaiei, no?oeoo?a e?noeiai? oeaieie iaaoaaea
iaeii??aeiino?.

Aoaeoeai?noue cai?iiiiiaaiiai niiniao e?eoaaiiy i?aeoaa?aeaeoaaeany e
aeaieie aoiinoaiiao??? (?en. 4). Aaea ia 14 aeiao a?aecia/aeiny
c?inoaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo c 2844±12 i/n aei 3009±37,
ui noaiiaeei a?aeiia?aeii 86% oa 91% ii?ie. Iiceoeaia oaiaeaioe?y
caa??aaeany e iaaeae?: ia 30 aeiao oaeaee?noue ?iciianthaeaeaiiy
oeueo?acaoeo aeinyaaea 3141±35 i/n (95% ii?ie); ia 60 aeiao — 3240±46
i/n (98% ii?ie); ia 90 aeiao — 3273±53 i/n (99% ii?ie); ia 180 aeiao —
3340±32 i/n (101% a?ae ii?ie). Iacia/ia ca?eueoaiiy oaeaeeino?
?iciianthaeaeaiiy o oa?i?i o?noue i?nyoe?a ii??aiyii c ii?iith iiaeia
iiynieoe ?ioaineaiith ia?aaoaeiaith oa ?aiiaeoeyoe??th ia?aeiiiai
e?noeiaiai iiciey.

Ia i?aenoaa? aeaieo ee?i?/ieo niinoa?aaeaiue, iiaeia c?iaeoe aeniiaie,
ui o?ainieaioaoe?y noniaic?? AEEE, caaaeyee ai?noo eiiieaeno a?ieia?/ii
aeoeaieo ?a/iaei, iiceoeaii aieeaa? ia ia?aa?a inoai?aia?aoeaieo
i?ioean?a o u?eei? ceaio ieaeiuei? uaeaie, aeoea?co? ooai?aiiy
e?noeiaiai iiciey, ? oei naiei nei?i/o? oa?i?ie e?eoaaiiy oa i?enei?th?
o?oaeiao ?aaa?e?oaoe?th oai?eo.

O?ainieaioaoe?y noniaic?? AEEE iniaeeai aoaeoeaia i?e e?eoaaii?
oneeaaeiaieo ceai?a ieaeiuei? uaeaie. Caaaeyee oeueiio iaoiaeo
aeoeaothoueny ?aaaia?aoe?ei? i?ioeane, noai?ththoueny oiiae aeey
o?ainoi?iaoe?? o?a?icii? oa o?yuiai? oeaieie a e?noeiao, ui i?enei?th?
e?eoaaiiy oa caai?iiy ceai?a, ?iaeoue e?eoaaiiy iaio o?aaiaoe/iei, ia
aeiaaa? aeiaeaoeiaeo ?icoe?aieo iia?aoeaieo ao?o/aiue.

Iiceoeai? ?acoeueoaoe io?eiai? iaie a 86% oai?eo c iaoneeaaeiaieie oa
94% oai?eo c oneeaaeiaieie ceaiaie ieaeiuei? uaeaie.

Ia i?aenoaa? iaaaaeaieo aeaieo, iiaeia noaa?aeaeoaaoe, ui canoinoaaiiy a
eiiieaeniiio e?eoaaii? iioeiaeaeaii? e?noeiai? oeaieie o?ainieaioaoe??
noniaic?? AEEE ye caniao aeoeaaoe?? a?aeiiaiiai i?ioeano oa i?io?eaeoeee
iiaeeeaeo oneeaaeiaiue ? aeineoue ia?niaeoeaiei a iaaeeoeei?, cie?aia a
uaeaiiai-eeoeaa?e o??o?a?? oa o?aaiaoieia??, iiaea aooe ?aeiiaiaeiaaiei
aeey oe?ieiai ai?iaaaeaeaiiy a ee?i?/io i?aeoeeo ye iaoiae aeai?o i?e
e?eoaaii? ceai?a ieaeiuei? uaeaie. Iaoiaeeea aeaioiaeaiiy, caa??aaiiy,
aaaaeaiiy o?ainieaioaoo i?inoa oa aeinooiia a oiiaao noaoe?iia?o ?
iie?ee?i?ee, a niin?a e?eoaaiiy i?ieoia ee?i?/i? aei?iaoaaiiy, ye?
i?aeoaa?aeeee eiai aoaeoeai?noue.
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870013016200e9000400000004010d0004000000020101000c000000320a6b00ed000300
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040000002d010200040000002701ffff030000001e00040000002d010100040000002d01
0800040000002d010500050000000102ffffff0005000000090200000000070000001604
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2d010800040000002d010200040000002701ffff030000001e00040000002d0101000400
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20010300000039382500090009001000040000002d010100040000002d01040004000000
2d010800040000002d010200040000002701ffff030000001e00040000002d0101000400
00002d010800040000002d010500050000000102ffffff00050000000902000000000700
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0100040000002d010800040000002d010500050000000102ffffff000500000009020000
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320a490052010300000039392500090009001000040000002d010100040000002d010400
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0902000000000700000016045400b4012f0081010400000004010d000400000002010100
0d000000320a3800850104000000313031250900090009001000040000002d0101000400
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ff00050000000902000000000700000016048a01c30100000000040000002d0104000400
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0000000000002200040000002d01070004000000f0010500040000000201020007000000
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ff00050000000902000000000700000016046d015b0137014900040000002d0104000400
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05000000090200000000040000002701ffff050000000b0200000000030000001e000500
00000102ffffff0005000000090200000000040000002701ffff030000000000

?en.4 I?ioeaioia ni?aa?aeiioaiiy iieaciee?a aoiinoaiiao??? a iniiai?e
a?oi? oa o ii?i?. Ca iieaciee ii?ie (100%) i?eeiyoi iieaciee
i?ioiaeaeaiiy oeueo?acaoeo ii iaooeiaeaeai?e ieaei?e uaeai?.

AENIIAEE

1. Aeai? iaoeiai-iaaee/ii? ?ioi?iaoe?? na?ae/aoue, ui i?iaeaia
iioei?caoe?? oa aeoeaaoe?? ?aia?aoeaiiai inoaiaaiaco ? iaeiei ?c
aaaeeeaeo iai?yi?a iaoeiaeo aeine?aeaeaiue a Oe?a?i?, ui iia’ycaii c
cia/iei c?inoaiiyi o?aaiaoecio uaeaiiai-eeoeaai? ae?eyiee, aaaee?noth
e?eoaaiiy oaeeo i?ioean?a, cia/iei a?aenioeii oneeaaeiaiue. A?aoiaoth/e
neeaaei?noue ea?oaaiiy ?aia?aoeaieie i?ioeanaie, ia?niaeoeaiei ia aeaiee
/an aaaaea?oueny aeei?enoaiiy a?ieia?/ieo iaoiae?a aieeao, cie?aia,
o?ainieaioaoe?? noniaic?? aia??iiaeueieo e?noeiaiiiceiaeo ee?oei.

2. O?ainieaioao AEEE ? noniaic??th aeaa?oae?ciaaieo aia??iiaeueieo
e?noeiaiiiceiaeo ee?oei, iiia?aaeiee?a o?a?iaeano?a inoaiaaiiiai ?yaeo,
io?eiaieo ?c e?noie 14-aeaiieo eo?y/eo aia??ii?a. I?e caaioiaeaii?
o?ainieaioaoo iaiao?aeia oa?i?/ia ia?iaea ia aiaeyi?e aai? i?e 56°N
ai?iaeiaae 30 oa, ui caaacia/o? eiai noa?ee?caoe?th.

3. Iaea?eueo ae?aaeaia ae?y noniaic?? AEEE — oea ?iaeoeoeaiee,
?i?oe?thth/ee aieea. ?? aoaeoeai?noue ? i?yii i?iii?oe?eia aei
eiioeaio?aoe?? o?ainieaioaoo. Caeaoi?noue aeoea?coaaoe ??no ee?oei
ae?aaeaia a o?ainieaioao? iacia/iith i??ith, ui aeyaey?oueny i?e eiai
iaaaeeeeo eiioeaio?aoe?yo.

4. I?e i?aeoe??i?e o?ainieaioaoe?? noniaic?? AEEE a oiiaao aenia?eiaioo
niinoa??aa?oueny ooai?aiiy aiaieu aeoii?/iiai inoaiaaiaco c oi?ioaaiiyi
aaeeiai? no?oeoo?e aoa/anoi? e?noeiai? oeaieie ia 90 aeaiue, ui
iiynith?oueny ae??th a?ieia?/ii aeoeaieo ?a/iaei o?ainieaioaoo ia
iaaeeoa?aioe?eiaai? iacaio?iaeuei? ee?oeie c iiaeaeueoith
i?ie?oa?aoe??th oa aeeoa?aioe?aoe??th a e?noeia?.

5. Aiae?c ?acoeueoao?a aenia?eiaioaeueieo aeine?aeaeaiue i?aeoaa?aeea,
ui caiiaiaiiy ae??/anoeo aeaoaeo?a ieaeiuei? uaeaie caaennth AEEE ni?ey?
i?enei?aiith i?ioean?a inoai?aaaia?aoe?? aiane?aeie ?ioaineai?oi?
i?ie?oa?aoe?? oa aeeoa?aioe?aoe?? inoaiaaiieo ee?oeiieo aeaiaio?a ?
i?eoaeaeoaiiio i?i?inoaiith i?e?inoaeei o ae?eyieo aeaoaeoo a ia??iae
i?ae 3-7 aeiai.

6. Caiiaiaiiy aenia?eiaioaeueieo ae??/anoeo aeaoaeo?a ieaeiuei? uaeaie
caaennth AEEE nei?i/o? oa?i?ie ooai?aiiy oa ia?aaoaeiae ?aaaia?aoo.
*a?ac 6 i?nyoe?a ia i?noe? aeaoaeoo niinoa??aaeany eiiiaeoia
i?ia?ae?ciaaia iiaiooai?aia e?noeiaa oeaieia inoaiiii? aoaeiae, yea ia
a?ae??ciyeany a?ae noi?aeieo ae?eyiie.

7. ?ic?iaeaiee oa ai?iaaaeaeaiee a ee?i?eo niin?a eiiieaeniiai e?eoaaiiy
o?aaiaoe/ieo ceai?a ieaeiuei? uaeaie c o?ainieaioaoe??th a ae?eyieo
iioeiaeaeaiiy ?i’?eoe?eiei iaoiaeii noniaic?? AEEE, nei?i/o? oa?i?ie
e?eoaaiiy ia 4-5 aei?.

8. Aaaaeaiiy ?i’?eoe?eiei oeyoii noniaic?? AEEE i?e e?eoaaii?
oneeaaeiaieo ceai?a ieaeiuei? uaeaie ni?ey? eiinie?aeaoe?? o?aaiaio?a o
cae/i? oa?i?ie oa a?aeiiaeaiith no?oeoo?e e?noeiai? oeaieie ia i?noe?
ceaio /a?ac 6 i?nyoe?a i?ney o?ainieaioaoe??.

9. Cai?iiiiiaaiee niin?a eiiieaeniiai e?eoaaiiy o?aaiaoe/ieo ceai?a
ieaeiuei? uaeaie oa eiai oneeaaeiaiue c o?ainieaioaoe??th noniaic?? AEEE
i?aeaeuo? aoaeoeai?noue e?eoaaiiy, nei?i/o? oa?i?ie ?aaa?e?oaoe??
oai?eo, ? caniaii i?io?eaeoeee i?neyo?aaiaoe/ieo oneeaaeiaiue.

IIOAE?EIAAI? ?IAIOE CA OAIITH AeENA?OAOe??

1. Iaiiianueeee ?.C., Aioue ?.I., N??ee I.I., Eiiieoeueeee ?.ss.
Canoinoaaiiy ee?oeiii? enaiia?aoio?ainieaioaoe?? i?e e?eoaaii?
o?aaiaoe/ieo ceai?a ieaeiuei? uaeaie c? niia?eueiaiith eiinie?aeaoe??th
// A?niee noiiaoieia??. – 1997. — ?3. – N.374-376.

2. Iaiiianueeee ?.C., Aioue ?.I., N??ee I.I. Aeeiai?ea eiinie?aeaoe??
e?noee i?e e?eoaaii? o?aaiaoe/ieo ceai?a ieaeiuei? uaeaie c
canoinoaaiiyi ee?oeiii? enaiia?aoio?ainieaioaoe?? // Iiaeie
noiiaoieia??. – 1997. — ?4. – N.46-48.

3. Iaiiianueeee ?.C. Eiiieaenia e?eoaaiiy o?aaiaoe/ieo ceai?a ieaeiuei?
uaeaie c? niia?eueiaiith eiinie?aeaoe??th ca aeiiiiiaith ee?oeiii?
enaiia?aoio?ainieaioaoe?? // I?aeoe/ia iaaeeoeeia. – 1998. — ?1-2. – N.
91-94.

4. Iaiiianueeee ?.C. Aieea noniaic?? aia??iiaeueieo e?noeiaiiiceiaeo
ee?oei ia ?ioaineai?noue i?ie?oa?aoe?? o?a?iaeano?a ethaeeie ca oiia
eoeueoo?e in vitro // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1998. —
?8. – N.104-111.

5. Iaoaio ia aeiao?ae, Oe?a?ia, ? 23896A, 6F61C7/00, A61B17/00. Niin?a
e?eoaaiiy ceai?a ieaeiuei? uaeaie ?c niia?eueiaiith eiinie?aeaoe??th /
Iaiiianueeee ?.C,, Aioue ?.I., N??ee I.I. (Oe?a?ia). — ?96051887;
Cayaeaii 14.05.96; Iioae. 31.08.98. Athe. ?6. – 3 n.

6. Aioue ?.I., Iaiiianueeee ?.C., N??ee I.I., Iaoetho A.A.
A?inoeioeyoe?y caai?iiy aino?eo ceai?a ieaeiuei? uaeaie //
Noiiaoieia?/i? iiaeie. – Euea?a: Ae?. «Ieeiea?a». — 1994. — N. 30-32.

7. Aioue ?.I., Iaiiianueeee ?.C., N??ee I.I., Iaoetho A.A., Ieaaeue
TH.I. Ii?oieia?/ia oa?aeoa?enoeea i?ioean?a ?aia?aoeaiiai inoaiaaiaco
i?e ee?oeii?e enaiia?aoio?ainieaioaoe?? a aenia?eiaio? // Iaoa??aee
iaoe. eiio.: «Aeooaeuei? i?iaeaie ooieoe?iiaeueii? aiaoii?? noaeeiii?
nenoaie». – Euea?a: A?/a. – 1995. – N.41-42.

8. Aioue ?.I., Eiiieoeueeee ?.ss., Iaiiianueeee ?.C., AEoe A.E.
Aeonoe/ia ae?aaiinoeea inoai?aia?aoeaieo i?ioean?a o o??o?a?/i?e
noiiaoieia?? // Aeooaeuei? i?iaeaie i?oiiaaee/ii? noiiaoieia??. –
Euea?a: AaeAeaio. – 1996. – N.28-29.

9. Aioue ?.I., Iaiiianueeee ?.C., N??ee I.I., Eiiieoeueeee ?.ss.
Canoinoaaiiy enaiia?aoio?ainieaioaoe?? a e?eoaaii? ceai?a ieaeiuei?
uaeaie c niia?eueiaiith eiinie?aeaoe??th // Iaoa??aee iaoe. eiio.:
«No/ani? i?iaeaie noiiaoieia??». – Euea?a: Ae?. EIO. – 1996. –
N.112-113.

10. Aioue ?.I., Iaiiianueeee ?.C., N??ee I.I., Eiiieoeueeee ?.ss.
E?eoaaiiy o?aaiaoe/ieo ceai?a ieaeiuei? uaeaie c niia?eueiaiith
eiinie?aeaoe??th iaoiaeii ee?oeiii? enaiia?aoio?ainieaioaoe?? //
Iaoa??aee iaoe.-i?ae. eiio.: «Iia? iaoiaeeee oa oaoiieia?? a
noiiaoieia??». – Euea?a: AEI «AIN». – 1997. – N.14.

AIIOAOe?ss

Iaiiianueeee ?.C. Iioei?caoe?y caai?iiy ceai?a ieaeiuei? uaeaie iaoiaeii
ee?oeiii? enaiia?aoio?ainieaioaoe??. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.22 – noiiaoieia?y. – Euea?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao, Euea?a, 1999.

Aeena?oaoe?eio ?iaioo i?enay/aii aea/aiith aoaeoeaiino? o?ainieaioaoe??
noniaic?? aia??iiaeueieo e?noeiaiiiceiaeo eo?y/eo ee?oei i?e e?eoaaii?
iaoneeaaeiaieo oa oneeaaeiaieo ceai?a ieaeiuei? uaeaie.
Aenia?eiaioaeueii, ia i?aenoaa? ?acoeueoao?a ?aae?i?cioiiiiai
aeine?aeaeaiiy ?ioaineaiino? i?ie?oa?aoe?? ethaenueeeo o?a?iaeano?a a
eoeueoo?? in vitro anoaiiaeaii nooi?iue ?i?oe?thth/iai oa aeoeaoth/iai
aieeao o?ainieaioaoo. Aeyaeaii caeaoi?noue noniaic?? aia??iiaeueieo
ee?oei oi?ioaaoe aiaieua aeoii?/iiai inoaiaaiaco i?e ?? i?aeoe??i?e
o?ainieaioaoe??. Aiae?c ?acoeueoao?a aenia?eiaioaeueieo aeine?aeaeaiue
i?aeoaa?aeea, ui caiiaiaiiy ae??/anoeo aeaoaeo?a ieaeiuei? uaeaie uo??a
ni?ey? i?enei?aiith i?ioean?a inoai?aaaia?aoe??. I?e aeei?enoaii?
enaiia?aoio?ainieaioaoe?? a eiiieaeniiio e?eoaaii? o?aaiaoe/ieo ceai?a
ieaeiuei? uaeaie aeyaeaii nei?i/aiiy oa?i?i?a e?eoaaiiy ia 4-5 aei?.
?i’?eoe?eia aaaaeaiiy o?ainieaioaoo i?e e?eoaaii? oneeaaeiaieo ceai?a
ieaeiuei? uaeaie (niia?eueiai?e eiinie?aeaoe??) ni?ey? caai?iith
iioeiaeaeaii? e?noee o cae/i? oa?i?ie oa iiaiiio a?aeiiaeaiith oeaieiieo
no?oeoo? ia i?noe? ceaio /a?ac 6 i?nyoe?a.

Eeth/ia? neiaa: ceaie ieaeiuei? uaeaie, ee?oeiia
enaiia?aoio?ainieaioaoe?y.

S U M M A R Y

Ogonovsky R.Z. Optimisation of mandibula traumatic fractures healing by
a method of cell xenobrefotransplantation. – Manuscript.

Dissertation to defend scientific degree of the candidate of medical
science; speciality 14.01.22 – stomatology; Lviv State Medical
University; Lviv 1999.

The dissertation is devoted to study of transplantate efficiency of hens
embrional marrow cell suspension at treatment of the not complicated and
complicated mandibula fractures. Experimentally, on the basis of
radioisotop research of proliferation intensity of human fibroblasts in
culture in vitro, there is established the degree of transplantation
initiating and activating influence. There is found out the ability to
form the centre of ectopical osteogeneses at hypodermic transplantation
of hens embrional marrow cell suspension. The analysis of experimental
researches has shown, that the filling of hole defects of the rat low
jaw, promotes acceleration of osteogeneses processes. At use of
xenobrefotransplantation in complex treatment of mandibula traumatic
fractures is revealed the reduction of terms of treatment for 4-5 days.
Transplantation injection at treatment of the complicated fractures
promotes consolidation-damaged bone in usual terms and complete
restoration of bone structures in the 6 months.

Key words: fractures of mandibula, cells xenobrefotransplantation.

AIIIOAOeEss

Iaiiianeee ?.C. Iioeiecaoeey caaeeaeaiey ia?aeiiia ieaeiae /aethnoe
iaoiaeii eeaoi/iie enaiia?aoio?ainieaioaoeee. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.22 – noiiaoieiaey. – Eueaianeee
ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Eueaia, 1999.

Oeaeue enneaaeiaaiey — iiauneoue yooaeoeaiinoue, nie?aoeoue a?aiy
ea/aiey e ?aaaeeeoaoeee aieueiie n ia?aeiiaie ieaeiae /aethnoe. Aeey
auiieiaiey iinoaaeaiiie oeaee a ?aaioa eniieueciaaee eiuaeoeeiiioth
o?ainieaioaoeeth acaane aeaaeoaeece?iaaiiuo yia?eiiaeueiuo
einoiiiicaiauo eeaoie, eioi?oth iieo/aee iooai iaoaie/aneie e oeie/aneie
aeennioeeaoeee aeieaeo o?oa/aouo einoae 14-15-nooi/iuo eo?eiuo yia?eiiia
n iineaaeothuae eo eiioeaio?aoeeae iooai oeaio?eooae?iaaiey i?e 1000
ia/iei a oa/aiee 5 iei. Ec-ca aiciiaeiiai ca?aaeaiey ieeiieaciaie e
ae?onaie, aeey aeaiaoo?aoeee oa?iieaaeeueiuo aaeeia, niiniaiuo aucaaoue
aeea?ae/aneea ?aaeoeee, i?iaiaeeee ia?aaioeo ieanoe/aneiai iaoa?eaea ia
aiaeiie aaia i?e oaiia?aoo?a 56°N a oa/aiea 30 iei. Inaaeie
?anoniaiaee?iaaee a eiina?aaioa «Aethaeoee?» a eiioeaio?aoeee eeaoie
1,5? 109 a 2-2,5 ie.

A oaeii aeaea o?ainieaioao o?aieee a ia?aoeie?iaaiiuo noa?eeueiuo
oeaeiiao a ii?iceeueiie eaia?a auoiaiai oieiaeeeueieea i?e oaiia?aoo?a
-4-10°N (no?ie nio?aiaiey i?aeoe/ii iaia?aie/aiiue). I?e iaiaoiaeeiinoe
o?ainieaioaoeee noniaiceth AEEE ?acii?aaeeaaee ia aiaeiie aaia i?e
oaiia?aoo?a +40° N.

I?e oeeoieiae/aneii enneaaeiaaiee iieo/aiiuo eeaoie iaaethaeaee
cia/eoaeueiia eiee/anoai i?ee?aieaiiuo e iiaa?oiinoe eeaoie caacae/aoie,
neaaea oaeeeiaiiie oi?iu, eioi?ua ianoaie i?eia?aoaee iieeaiiaeueiua
i?eciaee, e iacia/eoaeueiia eiee/anoai yaea?iuo ie?oaeuo e iaaeueiuo
eeaoi/iuo yeaiaioia, caaenoeo a ieoaoaeueiie n?aaea. Ia iniiaaiee
iieo/aiiuo aeaiiuo naeaeaii caeeth/aiea, /oi eniieueciaaiiue iaie
o?ainieaioao — noniaicey aeaaeoaeeci?iaaiiuo oa?ie/aneie ia?aaioeie e
caii?aaeeaaieai yia?eiiaeueiuo einoiiiicaiauo eeaoie, i?aaeoanoaaiieeia
oea?iaeanoia inoaiaaiiiai ?yaea, iieo/aiiiai n o?oa/aouo einoae
14-aeiaaiuo eo?eiuo yia?eiiia.

Aeey auyniaiey iaoaiecia, /oi iaania/eaaao iioeiece?othuea aeeyiea
enaiiaaiiiai yia?eiiaeueiiai o?ainieaioaoa ia ?aaaia?aoeaiua i?ioeannu a
einoiie oeaie, eco/aee aai aeeyiea ia i?ieeoa?aoeaioth aeoeaiinoue
yia?eiiaeueiuo oea?iaeanoia /aeiaaea i?e oneiaeyo eoeueoeae?iaaiey in
vitro. Enneaaeiaaee niiniaiinoue o?ainieaioaoa eieoeee?iaaoue
i?ieeoa?aoeeth eeaoie, eioi?ay auea i?aaeaa?eoaeueii inoaiiaeaia iooai
nicaeaiey aeaoeoeeoa oaeoi?ia ?inoa. Ia iniiaaiee ?aaeeiecioiiiiai
enneaaeiaaiey, onoaiiaeaii, /oi oaaee/aiea eiioeaio?aoeee acaane
a?aoieeaoie a eoeueoo?aeueiie n?aaea aei 10% niinianoaoao aeoeaaoeee
i?ieeoa?aoeee a 5,5 ?aca. I?e aaaaeaiee acaane a?aoieeaoie i?e
eiioeaio?aoeee 1% a eoeueoo?aeueioth n?aaeo, aaea eeaoee iaoiaeeeenue a
oneiaeyo eiaa?eoie/aneie oacu ?inoa, auyaeaii noeioee?othuea aeeyiea ia
o?iaia 2,1 ?aca. Oaaee/aiea eiioeaio?aoeee aaei e nieaeaieth
?inoinoeioee?othuaai aeeyiey o?ainieaioaoa.

Inoaieiaeoeoeaiua niiniaiinoe acaane yia?eiiaeueiuo eeaoie enneaaeiaaee
ia aaeuo e?unao, eioi?ui eiuaeoeeiiiui iooai aaiaeeee 0,5-0,6 ie
o?ainieaioaoa a iiaeeiaeioth iaeanoue aioo?aiiae iiaa?oiinoe aaae?a.
Aenoieiae/anee e 90-io aeith a 30-40% yenia?eiaioaeueiuo enneaaeiaaiee
iaia?oaeaiu i/aae yeoiie/aneiai inoaiaaiaca, i?aaenoaaeaiiuo
noi?ie?iaaiiuie aaei/iuie no?oeoo?aie aoa/aoie einoiie oeaie.

Yenia?eiaioaeueiua enneaaeiaaiey aeeyiey acaane YEEE ia oa/aiea einoiuo
?aia?aoeaiuo i?ioeannia i?iaiaeeee ia neaiciuo aeaoaeoao aeeaiao?ii 2,0
ii, eioi?ua nicaeaaaee a ieaeiae o?aoe ieaeiae /aethnoe iiuoiiai
aeeaioiiai (e?unu). Onoaiiaeaii, /oi oaea ia 14 nooee iaaethaeaeenue
?acee/ey a oa/aiee ?aia?aoeaiuo i?ioeannia: ia ?aioaaiia?aiao a iiuoiuo
neo/ayo ii?aaeaeyeanue caaoaee?iaaiiinoue aeaoaeoa, e?ay eioi?iai
naeaaeeaaeenue e oa?yee /aoeinoue. Yoe aea i?iyaeaiey a eiio?iea iaiaa
au?aaeaiiua. Oaeay aea ?aioaaiieiae/aneay ea?oeia n aieueoa /aoeei
eiio?anoe?iaaieai ii?aaeaeyeanue a iiuoa a aeaeueiaeoea no?iee
iaaethaeaiey (21 e 30 aeiae). Iieiaeeoaeueiay aeeiaieea aieueoa
eioaineaiiai ia?aciaaiey einoii-oeaiaaiai ?aaaia?aoa nio?aiyeanue e a
aeaeueiaeoai. Anee a iiuoiuo neo/ayo oaea ia 90 ii?o iinea o?aaiu
ii?aaeaeeoue a?aieoeu aeaoaeoa auei aeinoaoi/ii oyaeaei, a ia 180 aeaiue
iaaiciiaeii, e ioia/aeinue iieiia ainnoaiiaeaiea einoe, oi a eiio?iea
oaiue ioaa?noee aeaoaeoa ie?oaeie oi?iu ii?aaeaeyeanue aeaaea ia
?aioaaiia?aiiao eiia/iiai n?iea iaaethaeaiey (180 aeaiue).

Iieo/aiiua ?acoeueoaou ii?oieiae/aneeo enneaaeiaaiee, eae e
?aioaaiieiae/aneea aeaiiua, iiaeoaa?aeaeatho iieiaeeoaeueiia aeeyiea
o?ainieaioaoeee noniaicee YEEE ia i?ioeannu ?aia?aoeaiie ?aaaia?aoeee a
einoiuo aeaoaeoao. A ioee/ea io eiio?ieueiuo iaaethaeaiee, a iiuoa
i?ioeannu inoai?aaaia?aoeee i?ioiaeyo cia/eoaeueii auno?aa aneaaenoaea
aieaa eioaineaiie i?ieeoa?aoeee e aeeooa?aioeeaoeee inoaiaaiiuo
eeaoi/iuo yeaiaioia a ia?eiae iaaeaeo 3-7 aeiai iinea iia?aoeee, ?aiiaai
i?i?anoaiey iee?ininoaeia a ciio einoiiai aeaoaeoa, /oi a eiia/iii
?acoeueoaoa nie?auaao i?iaeieaeeoaeueiinoue caaeeaeaiey einoiie ?aiu.

A eeeieea o?ainieaioaoeeth acaane YEEE eniieueciaaee i?e ea/aiee
aieueiuo n o?aaiaoe/aneeie ia?aeiiaie ieaeiae /aethnoe e eo
ineiaeiaieyie – caiaaeeaiiie eiinieeaeaoeeae. O?ainieaioaoeeth
i?iaiaeeee a iniiaiii aioo?e?ioiaui iooai iinea i?oiiaaee/aneie
eiiiaeeecaoeee iaeiieia ieaeiae /aethnoe. I?e eniieueciaaiee
enaiia?aoio?ainieaioaoeee a eiiieaeniii ea/aiee o?aaiaoe/aneeo ia?aeiiia
ieaeiae /aethnoe iaia?oaeaii nie?auaiea n?ieia ea/aiey ia 4-5 aeiae.
Yooaeoeaiinoue eniieueciaaiey enaiia?aoio?ainieaioaoeee iiaeoaa?aeaeaii
aeaiiuie yoiinoaiiao?e/aneeo enneaaeiaaiee: ia 21 nooee ea/aiey a
iniiaiie a?oiia iieacaoaee nei?inoe ?ani?ino?aiaiey oeueo?acaoeo auee
3108±58 i/n (94% ii?iu), a eiio?ieueiie — 2976±30 i/n (90% ii?iu); ia 30
ii?o niioaaonoaaiii — 3207±49 i/n (97% ii?iu) e 3076±51 i/n (93% ii?iu).

I?e aaaaeaiee acaane YEEE aieueiui n caiaaeeaiiie eiinieeaeaoeeae ia
12-14 aeaiue iaaethaeaeinue ooieuaiea einoiie oeaie a iaoieiae/aneii
o/anoea aac ainiaeeoaeueiuo i?iyaeaiee, eioi?ia naeaeaoaeuenoaiaaei ia
eioaineaiii ia?aciaaiee ia?ae/iie einoiie iiciee. Ia 20-22 aeaiue
ioia/aeanue noieeay eiinieeaeaoeey iaeiieia, auyaeaiu ?aioaaiieiae/aneea
i?eciaee ieia?aeecaoeee ciiu ia?aeiia: e?ay iaeiieia noaiiaeeenue iaiaa
/aoeeie, naeaaeaiiuie, iaaeaeo ieie iaaethaeaeanue au?aaeaiiay
caaoaee?iaaiiinoue. I?e eiio?ieueiuo iniio?ao /a?ac iyoue-oanoue
ianyoeaa iinea o?aaiu ieeaeeo eeeie/aneeo i?eciaeia ia auyaeaii.
?aioaaiieiae/aneay ea?oeia o?aaie?iaaiiiai o/anoea ia ioee/aeanue io
ie?oaeathueo oeaiae, no?oeoo?a einoiie oeaie i?eia?aoaea iaeii?iaeiinoe.

Ia iniiaaiee aeaiiuo eeeie/aneeo iaaethaeaiee, iiaeii naeaeaoue auaiae,
/oi o?ainieaioaoeey noniaicee YEEE, aeaaiaea?y eiiieaeno aeieiae/anee
aeoeaiuo aauanoa, iieiaeeoaeueii aeeyao ia oiae inoai?aia?aoeaiuo
i?ioeannia a iaeanoe ia?aeiia ieaeiae /aethnoe, aeoeaece?oao ia?aciaaiea
einoiie iiciee, nie?auaao no?iee ea/aiey e onei?yao o?oaeiaoth
?aaaeeeoaoeeth aieueiie.

Eeth/aaua neiaa: ia?aeiiu ieaeiae /aethnoe, eeaoi/iay
enaiia?aoi-o?ainieaioaoeey.

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