*A?I?AAOeUeEEE AeA?AEAAIEE OI?AA?NEOAO

?i. TH.OAAeUeEIAE*A

ss?ai?e ??eia Ieeiea?aia

Oaee 577.1: 599.323.4–019: 615.322:
582.998.2

IENEAeAIOII-AIOEIENEAeAIOIEE NOAI I?AAI?CIO UO??A CA OIIA
IENEAeAIOIIAI NO?ANO OA Ae?? IANOIssIEE

A?I?EE A??NUeEI?

03.00.04 – a?io?i?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

*a?i?aoe?

1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai?? IIC
Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? a?ieia?/ieo iaoe, i?ioani? Iaueoai ?aai Oaaei?iae/,

Aoeiaeinueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie,

caa?aeoaa/ eaoaae?e iaaee/ii? o?i??

Io?oe?ei? iiiiaioe:

aeieoi? a?ieia?/ieo iaoe, i?ioani? Aeiia?aaeiaa ?oo?ia Iao??aia,

Ee?anueeee oi?aa?neoao ?iai? Oa?ana Oaa/aiea, eaoaae?a a?io?i??;

aeieoi? iaaee/ieo iaoe, i?ioani? Aiinueeee ss?ineaa ?aaiiae/,

Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss.
Ai?aa/aanueeiai,

caa?aeoaa/ eaoaae?e iaaee/ii? o?i??

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee oi?aa?neoao, eaoaae?a
a?io?i??

Caoeno a?aeaoaeaoueny » 17 ” /a?aiy 1999 ?. i 10 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 76.051.05 a *a?i?aaoeueeiio
aea?aeaaiiio oi?aa?neoao? ?i. TH. Oaaeueeiae/a, i.*a?i?aoe?,
aoe.Eioethaeinueeiai, 2.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? *a?i?aaoeueeiai
aea?aeaaiiai oi?aa?neoaoo ?i. TH. Oaaeueeiae/a (i.*a?i?aoe?, aoe. Ean?
Oe?a?iee, 23).

Aaoi?aoa?ao ?ic?neaiee “ 14 ” o?aaiy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao a?ieia?/ieo iaoe
Eiieeue/oe A.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeine?aeaeaiiy inoaii?o ?ie?a ia?aeiiothoue o
iaaaaaoi a?eueoiio, i?ae aaaaeaeinue ?ai?oa, aieeaia? ia a?ieia?/i?
nenoaie aeoeaieo oi?i eenith oa caeaaeii? a?ae ieo aioo??oiueiee?oeiii?
aaia?aoe?? a?eueieo ?aaeeeae?a [Eiaeiia A.N., Iaothoei A.I., 1991, 1996,
Aeaaeeie?ia TH.A., 1998] .Ca?aeii no/anieo oyaeaiue, neiae?ii
ia?ieneaeaoe??, ye ianiaoeeo?/ia iaoio?c?ieia?/ia ?aaeoe?y, a?ae?a?a?
i?ia?aeio ?ieue o iaoiaaiac? ??ciiiai?oieo caoai?thaaiue ?
?icaeyaea?oueny ye oi?aa?naeueiee iaoai?ci iioeiaeaeaiiy ee?oei [Aa?aaie
A.A., 1997, Aeaaeeie?ia TH.A., 1998]. Aioo??oiueiee?oeiia ?aaoeyoe?y a
oeaieiao ai?noo aeoeaieo oi?i eenith oa ?ioaineaiino? ia?aa?ao i?ioean?a
ia?ieneaeiiai ieeneaiiy e?i?ae?a oa a?iiie?ia??a cae?enith?oueny ca
aeiiiiiaith oa?iaioaoeaieo oa iaoa?iaioaoeaieo nenoai aioeieneaeaioiiai
caoenoo [Cai?ianeay E.A., 1995, Aa?aaie A.A., Nooeiaie Ae.A., 1997,
Iaueoai ?.O., 1999].

Aeey c’ynoaaiiy iaoai?ci?a oi?ioaaiiy oa ia?aa?ao ??ciiiai?oieo
iaoieia?/ieo noai?a a i?aai?ci? oa c iaoith aeyaeaiiy a iaoiaaiac?
ie?aieo caoai?thaaiue oeo eaiie, ae?th/e ia ye?, iiaeia aieeaaoe ia
?icaeoie a i?aai?ci? iaoieia?/iiai i?ioeano, i?iaiaeyoueny eiiieaeni?
aeine?aeaeaiiy ai?noo a oeaieiao i?iaeoeo?a ia?ieneaeiiai ieeneaiiy
a?iiieaeoe, cie?aia e?i?ae?a oa ooieoe?iioaaiiy nenoai aioeieneaeaioiiai
caoenoo.

Ca inoaii? aeanyoe??//y, o ca’yceo ?c cia/iei iia??oaiiyi aeieia?/ii?
neooaoe??, a Oe?a?i? cia/ii c??n i?ioeaio caoai?thaaiino? ianaeaiy. Ca
oaeeo oiia aeoeai?noue aeanieo nenoai aioe?aaeeeaeueiiai caoenoo
i?aai?cio aeiaie? /anoi aeyaey?oueny iaaeinoaoiueith aeey ?aaoeyoe??
??aiy a?eueieo ?aaeeeae?a ? iio?aao? aeiaeaoeiaiai aaaaeaiiy a i?aai?ci
aeciaaiieo aioeieneaeaio?a. Oiio, c?icoi?eei ia iaoo aeoieo, ? ?ioa?an
oa iineeaiee iiooe iiaeo cania?a i?e?iaeiueiai, cie?aia ?ineeiiiai
iioiaeaeaiiy, caeaoieo caiia?aaoe ?ioaineaiiio ?aaeeeaeiooai?aiith /e
ni?eyoe e?au?e iia?e?caoe?? aeanieo nenoai aioe?aaeeeaeueiiai caoenoo
i?aai?cio [Eieaniaa E.I., 1996, Ooe?iaiei ?.I.,1998].

Ia?niaeoeaiith, ia iaoo aeoieo, a oeueiio ieai? e?ea?nueeith ?ineeiith
ne?ae aaaaeaoe a?i?eo a??nueeo, yea, ye na?ae/aoue e?oa?aoo?i? aeai?
[Einoaiieeiaa C.I., 1984, Rosetti V., 1987, Pinchon T., 1988], i?noeoue
cia/io e?euee?noue a?ieia?/ii aeoeaieo ?a/iaei c ??ciiiai?oiith
oa?iaeieia?/iith ae??th.

Aea/aiiy aieeao ianoiyiee a?i?ee a??nueei? ia noai ieneaeaioii? oa
aioeieneaeaioii? nenoai i?aai?cio ca oiia ieneaeaioiiai no?ano
aeiiiiiaei a ia eeoa iiynieoe aeaye? iaoai?cie ?? a?ieia?/ii? ae??, a e
cia/ii ?icoe?eei a iiaeeeaino? uiaei aeei?enoaiiy aeaiiai i?aia?aoo a
ee?i?/i?e i?aeoeoe?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
i?iaiaeeeanue a ?aieao iaoeiai-aeine?aeieoeueei? ?iaioe Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai??. ?a?no?aoe?eiee N 0197V015108.

Iaoa ? iniiai? caaaeaiiy aeine?aeaeaiiy. Anoaiiaeoe oa?aeoa? aieeao
ianoiyiee a?i?ee a??nueei? ia noai ieneaeaioii? oa aioeieneaeaioii?
nenoai i?aai?cio uo??a ca oiia ieneaeaioiiai no?ano (ae?? iecueeeo aeic
?aae?aoe??, aenia?eiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiy
aano?iaeoiaeaiaeueii? ciie oa oiene/iiai aaiaoeoo).

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? ianooii? caaaeaiiy:

1. Aeine?aeeoe ai?no iieaeoey?ieo i?iaeoeo?a IIE (niieoe c ?cieueiaaieie
iiaea?eieie ca’yceaie, ae??iiaeo eii’thaao?a, eaoiae??i?a ? ni?yaeaieo
o?e?i?a, iaeiiiaiai aeeaeueaeaa?aeo) oa ooieoe?iioaaiiy nenoai
aioeieneaeaioiiai caoenoo (ai?no oea?oeiieaci?io, aeooao?iio
a?aeiiaeaiiai oa aeoeai?noue noia?ieneaeaeeniooace, eaoaeace,
aetheici-6-oinoaoaeaa?ae?iaaiace, aeooao?ii?aaeoeoace,
aeooao?iiia?ieneaeace, aeooao?ii-S-o?ainoa?ace) a e?ia? oa ia/?ioe?
uo??a ca oiia iaeii?aciaiai ?aioaai?anueeiai ii?ii?iaiiy a aeic? 0,5 A?,
aenia?eiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiiy
aano?iaeoiaeaiaeueii? ciie oa oiene/iiai aaiaoeoo.

2. Aea/eoe o?ceei-o?i?/i? iieacieee ianoiyiee a?i?ee a??nueei?, cie?aia,
i?iaanoe aeine?aeaeaiiy ii aeyaeaiith oa aecia/aiith a inoaii?e ai?noo
i?e?iaei?o aioeieneaeaio?a.

3. Aeine?aeeoe in vitro oa?aeoa? ae?? ianoiyiee a?i?ee a??nueei? ia
i?iieei?noue iaia?ai a?eo?ioeeo?a aeiii??a oa noai ia?ieneaeiiai
ieeneaiiy aiaeiaaiieo e?i?ae?a.

4. Aea/eoe aieea ianoiyiee a?i?ee a??nueei? ia noai ia?ieneaeiiai
ieeneaiiy e?i?ae?a oa nenoai aioeieneaeaioiiai caoenoo e?ia? oa ia/?iee
uo??a ca oiia iaeii?aciaiai ii?ii?iaiiy a aeic? 0,5 A?,
aenia?eiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiy aano?iaeoiaeaiaeueii?
ciie oa oiene/iiai aaiaoeoo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. A aeai?e ?iaio? aia?oa:

anoaiiaeaii oa?aeoa? ae?? ianoiyiee a?i?ee a??nueei? ia i?iieei?noue
ee?oeiieo iaia?ai a?eo?ioeeo?a aeiii??a, aeyaeaii aioeieneaeaioi?
aeanoeaino? ianoiyiee a?i?ee a??nueei? oa aea/aii iaoai?cie
aioeieneaeaioii? ae?? i?aia?aoo ye ca oiia o?c?ieia?/ii? ii?ie, oae ?
i?e iaoieia??: ae?? iecueeeo aeic ?aae?aoe??, a?iceaii-ae?aceiaiio
o?aaeaii? aano?iaeoiaeaiaeueii? ciie oa oiene/iiio aaiaoeo?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Iieacaia aoaeoeai?noue canoinoaaiiy ianoiyiee a?i?ee a??nueei? ca oiia
ae?? iecueeeo aeic ?aae?aoe?? oa iaa?oioiaaia iiaeeea?noue aeei?enoaiiy
?? a iaaee/i?e i?aeoeoe? ye aioeieneaeaioiiai caniao i?e
a?iceaii-ae?aceiaeo o?aaeaiiyo oeoieiai-eeoeiaiai o?aeoo oa ye
aaiaoii?ioaeoi?a.

Ca iaoa??aeaie aeena?oaoe?? ?ic?iaeaii ?aoei?iiiceoe?th *a?i?aaoeueeiai
iaae?inoeoooo N26/95 “Aioeieneaeaioia ae?y ianoiyiee a?i?ee a??nueei?”.

Iniaenoee aianie caeiaoaa/a. Iniaenoee aianie aaoi?a a io?eiaii?
iaoeiaeo ?acoeueoao?a ? iniiaiei ? iieyaa? o noi?ioethaaii? iaoe ?
caaaeaiue aeine?aeaeaiiy, i?iaaaeaii? iniiaiiai ia’?io
aenia?eiaioaeueii? /anoeie ?iaioe, ii?aoethaaii? iaoeiai? e?oa?aoo?e,
noaoenoe/i?e ia?iaoe? ?acoeueoao?a aeine?aeaeaiue, aiae?c? oa
ocaaaeueiaii? io?eiaieo aeaieo, ai?iaaoe?? io?eiaieo ?acoeueoao?a ?
i?aeaioiaoe? aei ae?oeo ?ia?o, ui a?aeia?aaeathoue iniiaiee ci?no
aeena?oaoe??.

Ai?iaaoe?y ?acoeueoao?a ?iaioe. Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe aeeeaaeai? ia: iaoeia?e eiioa?aioe?? aeeeaaea/?a, ni?a?ia?oiee?a
oa nooaeaio?a, i?enay/ai?e 120-??//th canioaaiiy *a?i?aaoeueeiai
oi?aa?neoaoo (*a?i?aoe?, 1995?.), neiiic?oi? “Aeooaeuei? ieoaiiy
iaaee/ii? aeiiiiiae ianaeaiith” (*a?i?aoe?, 1996), II Oe?a?inuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? ii ia?iaei?e ? iao?aaeeoe?ei?e
iaaeeoeei? (Aei?i?iiao?ianuee, 1996), iaoeia?e eiioa?aioe?? “Aeooaeuei?
ieoaiiy ii?oiaaiaco” (*a?i?aoe?, 1996?.), VII Oe?a?inueeiio a?io?i?/iiio
c’?cae? (Ee?a, 1997?.), Ae?oaiio i?aeia?iaeiiio iaaee/iiio eiia?an?
nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue,1998?.), III Oe?a?inuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? c ia?iaeii? oa iao?aaeeoe?eii?
iaaeeoeeie (Ee?a, 1998?.), ca?oieo iaoeiaeo eiioa?aioe?yo Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (1998, 1999?).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 15 ?ia?o (8 noaoae oa 7
oac aeiiia?aeae), c ieo 6 o oaoiaeo aeaeaiiyo.

No?oeoo?a oa ianya ?iaioe. ?iaioa aeeeaaeaia ia 176 noi??ieao ?
neeaaea?oueny ?c ainueie ?icae?e?a: anooio, iaeyaeo e?oa?aoo?e,
iaoa??ae?a oa iaoiae?a, ?acoeueoao?a aeine?aeaeaiue i?aaenoaaeaieo o 5
?icae?eao, ocaaaeueiaiiy iaea?aeaieo aeaieo, aeniiae?a oa i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae (283 aeaea?aea, c yeeo 95 –
?iicaiieo aaoi??a). ?iaioa i?noeoue 20 oaaeeoeue oa 2 ?enoiee.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Aenia?eiaioaeuei? aeine?aeaeaiiy aoei i?iaaaeaii ia 290 a?eeo
aacii?iaeieo uo?ao ianith 135-145 a oa a?eo?ioeeoao e?ia? 24 aeiii??a.

O ?iaio? aeei?enoiaoaaee nie?oiao ianoiyieo a?i?ee a??nueei? (IAA), yea
aoea aeaioiaeaia ?c aenooaieo nooea?oue Arnica montana L. o
ni?aa?aeiioaii? (1:10), niiniaii iaoea?aoe?? (ianoithaaiiy) ia 70%
aoeeiaiio nie?o? ? a?aeiia?aeaea on?i iinoaaeaiei aei ia? aeiiaai
ca?aeii Aea?aeaaii? oa?iaeiia? oa ON 42-206183 (Ia-noieea a?ieee).

Aea/aiiy oa?aeoa?o ae?? ianoiyiee a?i?ee a??nueei? ia i?iieei?noue
iaia?ai a?eo?ioeeo?a aeiii??a ca oiia a?iioii?/iiai aaiie?co oa aieea
inoaiiuei? ia oaeaee?noue ?iaeoeiaaiiai in vitro oa?iaioaoeaiiai
(IAAeOI-caeaaeiiai) oa iaoa?iaioaoeaiiai (anei?aao-caeaaeiiai)
ia?ieneaeiiai ieeneaiiy aiaeiaaiieo e?i?ae?a i?iaiaeeeeny ca?aeii
iienaieo ?ai?oa iaoiae?a (?.O. Iaueoai, 1991).

sse iiaeae? ieneaeaioiiai no?ano o uo??a aoei aeei?enoaii: ii?ii?iaiiy a
aeic? 0,5 A?, a?iceaii-ae?aceiaa o?aaeaiiy aano?iaeoiaeaiaeueii? ciie oa
oiene/iee aaiaoeo.

Ii?ii?iaiiy oaa?ei i?iaiaeeee ?aioaai?anueeei ae?aaiinoe/iei aia?aoii
12 I6, iaeii?aciai a noia?i?e aeic? 0,5 A? ca oaeeo oiia: iai?oaa 40 eA,
neea no?oio 80 iA, o?eueo?e 0,5 ii Nu, oe??ii-oieonia a?aenoaiue 40 ni,
iiooaei?noue aeice 1 ?/naeoiaeo. Aiia?ao, yeee aeei?enoiaoaaee, aoa
i?enoiniaaiee aei iaoeo iio?aa, ??aiii??i?noue ii?ii?iaiiy ii ieiu?
eiio?iethaaee ca aeiiiiiaith aeiceiao?a. Oaa?ei ii?ii?ithaaee a
niaoe?aeueieo ee?oeao ii 5 a eiaei?e na???, ui aeaaaei iiaeeea?noue
?icoaooaaoe oaa?ei a iaaeao oieonii? ieyie ?aioaaiaia?aoo.

A?iceaii-ae?aceiaa o?aaeaiiy aano?iaeoiaeaiaeueii? ciie (AAO) o uo??a
aeeeeeaee ca ?ic?iaeaiith ?ai?oa iaoiaeeeith (I.?. Aieioei, ?.O.Iaueoai,
1986). Oaa?eiai i?ioyaii 12 aei?a ia?i?aeueii aaiaeeee noi?o, ui
neeaaeaeany c 10% ?ic/eio eiina?aiaaii? iaaee/ii? aeia/? (10 ie/ea),
?iaeiiaoaoeeio (3ia/ea) oa aoeaoeenae?oeeeiai? eeneioe (100 ia/ea).

Oiene/iee aaiaoeo o uo??a aeeeeeaee oeyoii aioo??oiueioeoieiaiai
aaaaeaiiy oaa?eiai oao?aoei?iaoaio, aeai?aciai (/a?ac aeaiue), ?c
?ic?aooieo 0,25 ie/100a iane o?ea oaa?eie o aeaeyae? 50%-iiai ie?eiiai
(ieeaeiaiai) ?ic/eio (TH.E.Aoaneee, 1984; I.I. Neaeoi, 1989).

Aeine?aeieo oaa?ei ?icae?eaii ia o?e a?oie: 1 – ?ioaeoi? uo??
(eiio?ieue), 2 – iae?eiaai? uo?? c iiaeaeueiaaiei ieneaeaioiei no?anii,
3 – uo??, ye? ye ei?aaoth/ee can?a io?eioaaee ianoiyieo a?i?ee
a??nueei?.

Oaa?ei caaeaaee aeaeai?oaoe??th i?ae eaaeei ao??iei ia?eicii. E?ia
a?aeae?aee a i?enooiino? AAeOA a eiioeaio?aoe?? 1 ia/ie oe?eueii? e?ia?.
A oe?euei?e e?ia? aecia/aee ai?no: niieoe c ?cieueiaaieie iiaea?eieie
ca’yceaie (?IC), ae??iiaeo eii’thaao?a (AeE), eaoiae??i?a ? ni?yaeaieo
o?e?i?a (EAe ? NO) (E.A. Aie/aai?neee e ae?., 1989), aeooao?iio
a?aeiiaeaiiai (AA) (I.A. O?aaeia, 1955). A aiiiaaiaoao ia/?iee oa
no?iie oeoieo uo??a aecia/aee ai?no niieoe c ?IC, AeE, EAe ? NO (?.A.
Ia/aithe, 1993 ) oa iaeiiiaiai aeeaeueaeaa?aeo (IAeA)
(TH.A. Aeaaeeie?ia, A.E.A?/aeia, 1972). A aaiie?caoao e?ia? oa
aiiiaaiaoao ia/?iee uo??a aecia/aee aeoeai?noue: noia?ieneaeaeeniooace
(NIAe) [EO 1.15.1.1] (A.A. Aeoaeieia e niaao., 1983), eaoaeace [EO
1.11.1.6] (I.A. Ei?iethe e niaao., 1988),
aetheici-6-oinoaoaeaa?ae?iaaiace (A-6-OAeA) [EO 1.1.1.49] (TH.E.
Caoa?ueei, 1967), aeooao?ii-?aaeoeoace (A?) [EO 1.6.4.2.] (E. Beutler,
1969), aeooao?iiia?ieneaeace (AI) [EO 1.11.1.9] (?.A. Aa?oo, ?.O.
Iaueoai, 1998). A ieaci? e?ia? oa aiiiaaiaoao ia/?iee aecia/aee
aeoeai?noue aeooao?ii-S-o?ainoa?ace (A-S-O) [EO 2.5.1.18] (Habig I.,
1974). Ai?no oea?oeiieaci?io (OeI) [EO 1.16.3.1] a ieaci? e?ia?
aecia/aee ca iiaeeo?eiaaiei iaoiaeii ?aa?ia, a ai?no IAeA a a?eo?ioeeoao
e?ia? – ca I.A. Aaneeueaaith oa ?.O. Iaueoaiei, 1998.

Iaea?aeai? aenia?eiaioaeuei? aeai? ia?iaeyee noaoenoe/ii c aeei?enoaiiyi
t-e?eoa??th No’thaeaioa (E.A. Ieaei, 1960).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

O?ceei-o?i?/i? iieacieee oa a?ieia?/i? aeanoeaino? ianoiyiee a?i?ee
a??nueei?

Ca?aeii io?eiaieo ?acoeueoao?a, ianoiyiea c nooea?oue a?i?ee a??nueei?
i?noeoue cia/io e?euee?noue i?e?iaeieo aioeieneaeaio?a. Oea, cie?aia,
oeaaiii?aee oa ?io? iie?oaiieuei? niieoee (eaa?oeaoei, ?ooei,
oei?iaaiiaa eeneioa, aeoaeeuei? ?a/iaeie), nanea?oa?iaie (a?i?oie?i),
anaioe?aeuei? aee?i? eeneioe (iea?iiaa, e?iieaaa oa e?iieaiiaa),
anei?a?iiaa eeneioa, aaeaiio??aoe, b-ea?ioei.

Aea/aiiy oa?aeoa?o ae?? ianoiyiee a?i?ee a??nueei? ia i?iieei?noue
iaia?ai a?eo?ioeeo?a aeiii??a ca oiia a?iioii?/iiai aaiie?co oa
i?iaaaeaiee a nenoai? in vitro ne?ei?ia aioeieneaeaioieo aeanoeainoae
ianoiyiee iieacaee, ui aeine?aeaeoaaiee i?aia?ao ia? ae?aaeai?
iaia?aiinoaa?e?coth/? oa aioeieneaeaioi? aeanoeaino? a aeineoue oe?ieiio
ae?aiacii? eiioeaio?aoe?e. Ca iniiao eiioeaio?aoe?? i?aia?aoo a
aenia?eiaioao in vitro iaie aoei ia?aii ai?no iaei??? c iniiaieo
ae?th/eo ?a/iaei a?i?ee – a?i?oie?io (521 ia/100a ianoiyiee). A
ae?aiacii? eiioeaio?aoe?e ianoiyiee a?i?ee, ui a?aeiia?aeathoue
5,21*10-7 –5,21*10-2 ia a?i?oie?-io/100a ianoiyiee aeyaeaia
iaia?aiinoaa?e?coth/a ae?y i?aia?aoo, a i?e eiioeaio?aoe?yo aeua
5,21*10-2 – niinoa??aaany aaiie?oe/iee aoaeo.

Ne?ei?ia aioeieneaeaioieo aeanoeainoae ianoiyiee a?i?ee a??nueei? in
vitro iieacaa, ui aaea ii/eiath/e c eiioeaio?aoe?? i?aia?aoo, ui
a?aeiia?aea? 5,21*10-6 ia a?i?oie?io/100a ianoiyiee ? aeua i?aia?ao
aaeueio? ?iaeoeiaaia Fe2+ ia?ieneaeia ieeneaiiy e?i?ae?a, i?i ui
na?ae/eei cieaeaiiy ai?noo iaeiiai c e?ioeaaeo i?iaeoeo?a IIE –
iaeiiiaiai aeeaeueaeaa?aeo.

Aeey iiaeoaa?aeaeaiiy io?eiaieo a oiiaao in vitro aeaieo i?i
aioeieneaeaioii aeanoeainoi ianoiyiee a?iiee ai?nueei? ie i?iaaee ?yae
aeineiaeaeaiue in vivo. Ineieueee iieiaeiia aaeueioaaiiy
IAAeOI-caeaaeiiai IIE niinoa?iaaeiny i?e eiioeaio?aoei? i?aia?aoo
2,605*10-3 ia a?i?oie?io/100 a ianoiyiee, oi a ia?a?aooieo ia 1 ea iane
o?ea iaiaoiaeii 0,2 ie ianoiyiee.

Noai ieneaeaioii? oa aioeieneaeaioii? nenoai i?aai?cio uo??a ca oiia
ae?? ianoiyiee a?i?ee a??nueei?

Oaa?eiai, ui iiia?aaeiuei aieiaeoaaee i?ioyaii 12 aiaeei, ianoiyieo
a?iiee ai?nueei? aaiaeeee uiaeaiii ia?i?aeueii a aeici 0,02 ie/100a iane
oaa?eie, o aeaeyae? 1 ie aiaeii-nie?oiaiai ?ic/eio (1:50). Oaa?ei
caaeaaee iaoiaeii aeaeaiioaoei? iiney eaaeiai aoi?iiai ia?eico /a?ac 12
oa 24 aiae, a oaeiae ia 3-, 7- oa 14-oo aeiao i?ney uiaeaiiiai
iaeii?aciaiai aaaaeaiiy i?aia?aoo. I?iaaaeaii aeineiaeaeaiiy
iiaeoaa?aeeee anoaiiaeaii ?aiioa a nenoaii in vitro aioeieneaeaioii
aeanoeainoi ianoiyiee a?iiee ai?nueei?.

Oae, ye iieacaii ia oaae. 1, aaea /a?ac 12 aiae iiney aaaaeaiiy uo?ai
ianoiyiee a?i?ee a??nueei? o e?ia? inoaii?o niinoa?iaaeiny cieaeaiiy
aiinoo ae??iiaeo eii’thaao?a.

Oaaeeoey 1.

Ai?no i?iaeoeo?a ia?ieneaeiiai ieeneaiiy e?i?ae?a a e?ia? uo??a ca oiia
ae?? ianoiyiee a?i?ee a??nueei? (I±m; n=8-20)

A?oie oaa?ei, oiiae aeine?aeoAeine?aeaeoaai? iieacieee (iaeeieoe?
aei??thaaiiiy)?IC,

A220/ ie e?ia?AeE,

A232 / ie e?ia?EAe ? NO,

A278/ ie e?ia?IAeA, iiieue/ie
a?eo?.Eiio?ieue4,180,091,700,080,760,0312,660,4212 aiaeei

3,700,131,420,09 0,710,0212,580,5724 aiaeeie

3,50,11 1,40,07 0,600,03 12,400,133 aeiae

2,860,18 1,350,09 0,580,02 10,140,367 ae?a

3,140,11 1,300,04 0,580,03 9,830,90 14 ae?a

3,920,071,300,12 0,670,0712,500,30

I?ei?oea: * — a??ia?aei? ci?ie aeine?aeaeoaaieo iieaciee?a ii??aiyii c
eiio?ieai (?<0,05). *a?ac 24 aiae iiney aaaaeaiiy ianoiyiee o e?iai oa ia/?ioe? uo?ia cieceany aiino onio i?ii?aeieo iieaeoey?ieo i?iaeoeoia IIE: niieoe c ?cieueiaaieie iiaea?eieie ca’yceaie, ae??iiaeo eii’thaao?a, eaoiae??i?a ? ni?yaeaieo o?e?i?a, ii??aiyii c ?ioaeoieie oaa?eiaie. Ai?no iaeiiai c e?ioeaaeo i?iaeoeo?a IIE – iaeiiiaiai aeeaeueaeaa?aeo a a?eo?ioeeoao e?ia? i?e oeueiio caeeoaany ia ?iaii oaa?ei eiio?ieueii? a?oie, a o ia/?ioe? – cieceany a na?aaeiueiio ia 13%. Uiaeaiia canoinoaaiiy ianoiyiee a?i?ee i?ioyaii 3 oa 7 aeiia i?ecaaei aei cieaeaiiy o e?ia? oa ia/?ioe? oaa?ei aiinoo on?o aeine?aeaeoaaieo i?iaeoeo?a IIE, a ii??aiyii? c ?ioaeoieie uo?aie. O e?ia? oaa?ei, ye? io?eioaaee ianoiyieo i?ioyaii 14 aei?a, niinoa??aaee cieaeaiiy ai?noo ae??iiaeo eii’thaao?a a na?aaeiueiio ia 23%, a a ia/?ioe? – ae??iiaeo eii’thaao?a oa iaeiiiaiai aeeaeueaeaa?aeo– ia 14 oa 11% a?aeiia?aeii, o ii??aiyii? c ?ioaeoieie oaa?eiaie. ?aooa aeine?aeaeoaaieo iieaciee?a IIE o e?ia? oa ia/?ioe? uo??a, ye? uiaeaiii i?ioyaii aeaio oeaei?a io?eioaaee ianoiyieo a?i?ee a??nueei? i?aeoe/ii ia a?ae??ciyeeny a?ae oaeeo o oaa?ei eiio?ieueii? a?oie. ?aaoeyoeiy i?ioeania IIE o eeioeii, ye a?aeiii, caeienith?oueny ca aeiiiiiaith nenoai aioeieneaeaioiiai caoenoo. Caiaeii io?eiaieo ?acoeueoaoia (oaae.2), iaeii?aciaa aaaaeaiiy iioaeoiei oaa?eiai ianoiyiee a?iiee ai?nueei? (1:10) a aeic? 0,2 ie/ea iane uo?a aeoeao? ooieoeiiioaaiiy nenoai aioeieneaeaioiiai caoenoo e?iai. Oae, oaea /a?ac 12 aiaeei iiney aaaaeaiiy i?aia?aoo a e?iai oa ia/?ioe? oaa?ei aeineiaeii? a?oie niinoa?iaaeiny iiaeaeuaiiy aeoeaiinoi aeooao?iiia?ieneaeace (ia 14 oa 16%, a?aeiia?aeii). A ia/?ioe? uo??a niinoa??aaeiny oaeiae oei/aniaa i?aeaeuaiiy aeoeaiino? aeooao?ii-S-o?ainoa?ace, aeoeai?noue yei? /a?ac 24 aiaeeie ii?iae?coaaeany ? caeeoaeany ia oaeiio ae ??ai? o an? ?aooo no?iee aeine?aeaeaiiy. *a?ac 24 aiaeeie iiney aaaaeaiiy uo?ai ianoiyiee a?iiee a e?ia? oa ia/?ioe? uo??a niinoa?iaaee iiaeaeuaiiy aeoeaiinoi noia?ieneaeaeeniooace, eaoaeace, aeooao?iiia?ieneaeace oa aiinoo oea?oeiieaci?io. Aiino aeooao?iio a?aeiiaeaiiai cieceany, i/aaeaeii, /a?ac iineeaia eiai aeei?enoaiiy aeooao?iiia?ieneaeacith, i?ioa i?e iiaoi?iiio aaaaeaii? i?aia?aoo a?aeiiaethaaany aei ??aiy oaa?ei eiio?ieueii? a?oie ? caeeoaany ia oaeiio ae ??ai? aei e?ioey aenia?eiaioo, ui, ?iia??ii, iia’ycaii c iineeaiiyi i?ioeano ?aaaia?aoe?? eiai c ieeneaii? oi?ie, i?i ui na?ae/eei i?aeaeuaiiy aeoeaiino? aetheici-6-oinoaoaeaa?ae?iaaiace oa aeooao?ii?aaeoeoace. Ia aeeeth/aia oaeiae iiaeeea?noue aeoeaaoe?? neioaco aeooao?iio a ia/?ioe? i?ae ae??th i?aia?aoo. Ca oiia ?aaoey?iiai ia?i?aeueiiai aaaaeaiiy oaa?eiai ianoiyiee a?iiee a??nueei? i?ioyaii 3 oa 7 aeiia o o?e aea aeic? iiaeaeuaiith o e?ia? oa ia/?ioe? uo??a aoea aeoeaiinoue: noia?ieneaeaeeniooace, eaoaeace, aetheici-6-oinoaoaeaa?ae?iaaiace, aeooao?ii?aaeoeoace, aeooao?iiia?ieneaeace oa ai?no oea?oeiieaci?io a ieaci?. Aiino AA a e?ia? oa ia/?ioe? uo??a, ye? io?eioaaee ianoiyieo, ia aiae?iciyany aiae oaeiai o iioaeoieo oaa?ei. I?e o?eaaeiio ?? aaaaeaii? (i?ioyaii aeaio oeaeiia) iiaeaeuaiith caeeoaeany eeoa aeoeaiinoue aetheici-6-oinoaoaeaa?ae?iaaiace a e?ia? oa aeooao?iiia?ieneaeace a ia/?ioe? uo??a. Oaaeeoey 2. Iieacieee aioeieneaeaioii? nenoaie e?ia? uo??a ca oiia ae?? ianoiyiee a?i?ee a??nueei? (I±m; n=8-20) A?oie oaa?ei, oiiae aeine?aeoAeine?aeaeoaai? iieacieee (iaeeieoe? aei??thaaiiy)NIAe, iae/ie e?ia?Eaoaeaca, ieiieue/oa a IbOeI, ia/ e ieacieA-6-OAeA, ieiieue / oa a IbA?, ieiieue / oa a IbAA, ieiieue / ie e?ia?AI, ieiieue/oa ie e?ia? Eiio?ieue 34,14 1,10132,10 4,29186,25 4,416,00 0,162,42 0,121,12 0,0622,03 0,6712 aiaeei 33,15 1,2139,22 9,07184,63 4,65,93 0,312,32 0,111,16 0,0425,11 0,9224 aiaeeie 37,58 0,77223,5114,29225,20 3,506,85 0,233,66 0,080,87 0,0330,4 0,993 aei? 39,99 1,7173,9711,60215,0 3,06,89 0,133,0 0,171,04 0,0426,22 0,537 aei?a 34,42 2,5153,94 7,9230,7 6,107,58 0,092,86 0,151,07 0,0530,4 0,9914 aei?a 30,24 0,16127,08 6,06206,53 14,206,70 0,072,7 0,101,02 0,0722,91 0,84I?ei?oea: * - a??ia?aei? ci?ie aeine?aeaeoaaieo iieaciee?a ii??aiyii c eiio?ieai (?<0,05). Ioaea, ianoiyiea a?iiee ai?nueei? i?e aaaaeaiii ?? a i?aaiici aaeueio? ia?aa?a i?ioean?a ia?ieneaeiiai ieeneaiiy e?i?ae?a oa noeioethth/a ae?? ia ooieoeiiioaaiiy nenoai aioeieneaeaioiiai caoenoo e?iai – iiaeaeuo? aeoeaiinoue noia?ieneaeaeeniooace, eaoaeace, aeooao?iiia?ieneaeace, oea?oeiieaci?io, ni?ey? ?aaaia?aoei? c ieeneaii? oi?ie aaaeeeaiai aiaeiaaiiiai aioeieneaeaioa e?ia? – aeooao?iio a?aeiiaeaiiai. Aeine?aeaeaiiy inoaii?o ?ie?a iieacaee ?nioaaiiy a i?e?iae? ae?aiaciio oae caaieo iaeeo aeic ?aae?aoe?? [Aa?aaie A.A., 1997], iaeiei c iieaeoey?ieo iaoai?ci?a iioeiaeaeoth/i? ae?? yeeo ? i?aeaeuaiiy a oeaieiao i?aai?cio eiioeaio?aoe?? aeoeaieo oi?i eenith, iineeaiiy aiane?aeie oeueiai i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a oa aeniaaeaiiy aioeieneaeaioieo ?aca?a?a ee?oeie. *a?ac 7 aei?a i?ney iaeii?aciaiai ii?ii?iaiiy oaa?ei a aeic? 0,5A? a e?ia? oa ia/?ioe? uo??a niinoa??aaee i?aeaeuaiiy ai?noo on?o aeine?aeaeoaaieo iieaeoey?ieo i?iaeoeo?a ia?ieneaeiiai ieeneaiiy e?i?ae?a (?en.1). picscalex100010009000003532b00000a00350000000000050000000902000000000500 00000102ffffff000400000004010d000400000002010200050000000c020001b5010300 00001e00040000002701ffff030000001e00040000002701ffff050000000b0200000000 030000001e00050000000102ffffff000500000009020000000012000000fb02f5ff0000 00000000bc02000000cc00000022417269616c2043797200cc00040000002d0100000400 00002d010000040000002d010000040000002d010000040000002d010000040000002d01 0000040000002d01000010000000fb021000070000000000bc02000000cc010202225379 7374656d00cc040000002d010100040000002701ffff030000001e00040000002d010000 050000000102ffffff00050000000902000000000700000016040001b501000000000400 00002d010100040000002701ffff030000001e00040000002d010000050000000102ffff ff00050000000902000000000700000016040001b50100000000040000002d0101000400 00002701ffff030000001e00040000002d010000050000000102ffffff00050000000902 00000000070000001604fc00b1010400040007000000fc02000080808000000004000000 2d01020009000000fa02050000000000000000002200040000002d010300050000000902 ffffff00050000000102808080000400000004010d0004000000020102000e0000002403 05003c00d8004000d4004c01d4004801d8003c00d80007000000fc020000ffffff000000 040000002d01040005000000090200000000050000000102ffffff000e00000024030500 3c00d8003c001a00400016004000d4003c00d8000e000000240305004000d40040001600 4c0116004c01d4004000d400070000001504af00b0015a00510109000000fa0200000000 0000000000002200040000002d010500040000002d010400040000002d01010004000000 2701ffff030000001e00040000002d010000040000002d010400040000002d0103000500 00000102ffffff0005000000090200000000070000001604fc00b1010400040007000000 fc020100000000008020040000002d01060009000000fa02000001000000000000002200 040000002d01070004000000f0010300050000000102000000000400000004010d000400 0000020102000e000000240305004c01d4004801d8003c00d8004000d4004c01d4000900 0000fa02000001000000808080002200040000002d01030004000000f001070007000000 1504af00b0015a0051010e000000240305003c00d8003c001a00400016004000d4003c00 d8000e000000240305004000d400400016004c0116004c01d4004000d400040000002d01 0500040000002d010400040000002d010100040000002701ffff030000001e0004000000 2d010000040000002d010600040000002d01030005000000010200000000050000000902 00000000070000001604fc00b1010400040009000000fa02000001000000000000002200 040000002d01070004000000f00103000400000004010d00040000000201020008000000 26060f000600ffffffff000009000000fa02050000000000ffffff002200040000002d01 030007000000fc020100000000000000040000002d010800040000000701040005000000 010280808000050000000902000000003500000042010500000028000000080000000800 0000010001000000000020000000c40e0000c40e00000200000002000000000000008080 80001f3e3e3e8f1f1f1fc78f8f8fe3c7c7c7f1e3e3e3f8f1f1f17cf8f8f83e7c7c7c0000 0000000000000000000000000000040000002d0109000c000000240304005100d8005100 610056005e005600d4000500000009020100000005000000010201000000040000002d01 080004000000f0010900040000002d010700040000002d01060004000000070101000800 000026060f000600ffffffff010007000000fc020100000000008020040000002d010900 0e000000240305005100d8005100610056005e005600d4005100d800040000002d010600 04000000f00109000800000026060f000600ffffffff0000040000002d01030004000000 2d0108000400000007010400050000000102ffffff000500000009020000000035000000 420105000000280000000800000008000000010001000000000020000000c40e0000c40e 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ffffffff0000000000000000ffffffffffffffff00000000000000000000000000000000 0000000000000000040000002d010b00040000002d010b00090000001d062100f0000700 070085005c01040000002d010b0005000000090201000000050000000102010000000400 00002d01090004000000f0010b00040000002d010600040000002d010700040000000701 01000800000026060f000600ffffffff010007000000fc02010000000000802004000000 2d010b00050000000102000000000400000004010d000400000002010200070000001b04 8d00640185005c01040000002d01070004000000f0010b00050000000102ffffff000400 000002010100040000002e0118000c000000320a8d00670109000000cdc0c32bce2bcdc0 c300040000002e010000040000002d010400040000002d010500040000002d0102000400 00002701ffff030000001e00040000002d010100040000002d010700040000002d010600 050000000102ffffff00050000000902000000000700000016049200b201420057010400 00002d010400040000002d010500040000002d010200040000002701ffff030000001e00 040000002d010100040000002d010700040000002d010600050000000102ffffff000500 0000090200000000070000001604d300be0100000000040000002d010a0004000000f001 0700040000002d01040004000000f0010600040000002701ffff050000000c02d300be01 030000001e00050000000102ffffff0005000000090200000000040000002701ffff0500 00000b0200000000030000001e00050000000102ffffff00050000000902000000000400 00002701ffff030000000000 ?en.2. Iieacieee nenoai aioeieneaeaioiiai caoenoo e?ia? uo??a ca oiia iaeii?aciaiai ii?ii?iaiiy a aeic? 0,5 A? oa ae?? ianoiyiee a?i?ee a??nueei? Aeoeai?noue aeooao?ii-S-o?ainoa?ace cieceeany a ia/?ioe? ii?ii?iaieo uo??a, i?ioa i?aeaeueeany a ieaci? e?ia?, ui, i/aaeaeii, ? ?acoeueoaoii iineeaiiy aeano?oeoe?? ieaciaoe/ieo iaia?ai ca oiia ae?? iaeeo aeic ?aae?aoe?? [Eaon I.O., 1997]. Aaaaeaiiy ii?ii?iaiei uo?ai ianoiyiee a?i?ee a??nueei? i?ioyaii 7 aei?a i?ney ii?ii?iaiiy c iaoith ei?aeoe?? iino?aae?aoe?eieo ii?ooaiue ieneaeaioii-aioeieneaeaioii? ??aiiaaae ni?eyei iie?auaiith aeine?aeaeoaaieo iieaciee?a: on? aiie ca aeeeth/aiiyi ai?noo eaoiae??i?a ? ni?yaeaieo o?e?i?a oa aeooao?iio a?aeiiaeaiiai a e?ia? ii?iae?coaaeeny. Ua aoaeoeai?oei aeyaeeiny canoinoaaiiy ianoiyiee a?i?ee a??nueei? c e?eoaaeueii-i?io?eaeoe/iith iaoith (i?ioyaii 7 aei?a aei oa 7 aei?a i?ney ii?ii?iaiiy). On? aeine?aeaeoaai? iieacieee IIE oa nenoai aioeieneaeaioiiai caoenoo a aeai?e a?oi? oaa?ei ia a?ae??ciyeeny a?ae oaeeo o ?ioaeoieo uo??a, ui na?ae/eoue i?i aenie? ?aae?ii?ioaeoi?i? iiaeeeaino? ianoiyiee a?i?ee a??nueei?. I?ioean ae?aceiooai?aiiy, ye a?aeiii [Caa?ooaiianeee O.A., 1988, Iana/ieeia A.Ae., 1988], oaeiae noi?iaiaeaeo?oueny ii?ooaiiyi a oeaieiao ieneaeaioii-aioeieneaeaioii? ??aiiaaae. Oae, ai?no niieoe c ?cieueiaaieie iiaea?eieie ca’yceaie, ae??iiaeo eii’thaao?a, eaoiae??i?a ? ni?yaeaieo o?e?i?a oa iaeiiiaiai aeeaeueaeaa?aeo a e?ia? oa ia/?ioe? uo??a c aenia?eiaioaeueiith ae?aceith ca?eueoeany a na?aaeiueiio a?aeiia?aeii ia 35, 14, 20, 51% oa ia 48, 29, 34, 61%. Ii?ooaiiy o ooieoe?iioaaii? nenoai aioeieneaeaioiiai caoenoo o uo??a c aenia?eiaioaeueieie a?iceaii-ae?aceiaeie o?aaeaiiyie aano?iaeoiaeaiaeueii? ciie oa?aeoa?ecoaaeeny o e?ia?, cie?aia, ??ceei i?eai?/aiiyi aeoeaiino? noia?ieneaeaeeniooace oa eaoaeace, aetheici-6-oinoaoaeaa?ae?iaaiace, aeniaaeaiiyi caian?a aeooao?iio a?aeiiaeaiiai (a na?aaeiueiio ia 10, 24, 16 oa 23%, a?aeiia?aeii), ii??aiyii c ?ioaeoieie oaa?eiaie (oaae. 3). O e?ia? oa ia/?ioe? uo??a c aenia?eiaioaeueiei a?iceaii-ae?aceiaei o?aaeaiiyi aano?iaeoiaeaiaeueii? ciie niinoa??aaeiny oaeiae eiiiainaoi?ia i?aeaeuaiiy aeoeaiino? aeooao?iiia?ieneaeace oa aeooao?ii?aaeoeoace. Oaaeeoey 3. Iieacieee aioeieneaeaioii? nenoaie e?ia? uo??a ca oiia aenia?aiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiy aano?iaeoiaiaeueii? ciie (AAO) oa ae?? ianoiyiee a?i?ee a??nueei? (IAA) (I±m; n=8-16) ? A?oie oaa?ei, Oiiae aeine?aeoAeine?aeaeoaai? iieacieee (iaeeieoe? aei??thaaiiy)NIAe, iae/ie e?ia?Eaoaeaca, ieiieue / oa a IbOeI, ia/e ieacieA-6-OAeA, ieiieue /oa a IbA?, ieiieue / oa a Ib AA, ieiieue/ie e?ia?AI, ieiieue/oa ie e?ia? A-S-T, iiieue/oa ie ie.·Eiio?ieue 33,87 0,76 134,49 9,84 211,9910,42 6,24 0,10 2,92 0,16 1,07 0,03 21,33 0,69 40,84 1,15 AAO 30,67 0,65 102,6610,0 371,8823,19 5,25 0,15 3,63 0,19 0,82 0,03 24,73 0,44 48,62 2,57 aeiaa AAO 30,73 1,01 105,845,73 409,914,88 5,31 0,18 3,47 0,18 0,84 0,05 25,21 1,1 46,43 2,17AAO + IAA 35,45 0,85 121,0 4,75 365,0415,89 5,96 0,29 3,35 0,11 0,93 0,04 22,4 1,05 40,23 1,1814 aeiaa AAO 32,93 0,97 113 6,42 335,7620,3 5,74 0,11 3,29 0,12 0,92 0,04 23,28 0,87 45,0 2,15AAO + IAA3304 0,80 144,088,39 219,3518,4 6,08 0,12 2,88 0,09 1,07 0,02 21,66 0,71 42,28 1,69 I?ei?oea:* -a??ia?aei? ci?ie aeine?aeaeoaaieo iieaciee?a ii??aiyii c eiio?ieai (?<0,05). Canoinoaaiiy ianoiyiee a?i?ee a??nueei? c iaoith ei?aeoe?? aeyaeaieo o uo??a c a?iceaii-ae?aceiaeie o?aaeaiiyie aano?iaeoiaeaiaeueii? ciie ii?ooaiue ieneaeaioii-aioeieneaeaioiiai aiiainoaco ni?eyei oaeaeoiio eiai a?aeiiaeaiith, a aeaioeaeiaaa canoinoaaiiy i?aia?aoo i?ecaaei aei iiaii? ?o ii?iae?caoe??. Oiene/iee aaiaoeo ?icaeyaea?oueny iei? [Aoaneee TH.E, 1984, 1989, Neaeoi I.I., 1989] ye oi?aa?naeueia iiaeaeue iieaeoey?ii? iaoieia?? ee?oeiieo iaia?ai, ii?ooaiiyo no?oeoo?e oa ooieoe?e yeeo ? eeth/iaei i?ioeanii o ?icaeoeo aaaaoueio ??cieo ca ao?ieia??th iaoieia?/ieo noai?a. Iaeiei c iieaeoey?ieo iaoai?ci?a aaiaoioiene/ii? ae?? oao?aoei?iaoaio ?, ye a?aeiii [Aoaneee TH.E., 1989, Neaeoi I.I., 1989], eiai i?iieneaeaioiee aoaeo. Aaaaeaiiy uo?ai oao?aoei?iaoaio aaaea aei oi?ioaaiiy a i?aai?ci? oaa?eie oae caaiiai “ieneaeaioiiai no?ano”. Oae, aaea a ia?o? no?iee io?o?iiy uo??a a ia/?ioe? inoaii?o niinoa??aaeiny i?eai?/aiiy nenoai aioeieneaeaioiiai caoenoo (oaae. 4), ca aeeeth/aiiyi aeoeaiino? aeooao?iiia?ieneaeace, aeoeai?noue yei? /a?ac aeiao i?ney ?ioieneeaoe?? aoea i?aeaeuaiith (ia 47%), ii??aiyii c eiio?ieai, oa nooo?aa iaeiie/aiiy on?o aeine?aeaeoaaieo iaie iieaeoey?ieo i?iaeoeo?a IIE (oaae. 5).Oaaeeoey 4. Iieacieee aioeieneaeaioii? nenoaie ia/?iee uo??a ca oiia aenia?eiaioaeueiiai oiene/iiai aaiaoeoo oa ae?? ianoiyiee a?i?ee a??nueei? (IAA) (I±m; n=8-20) A?oie oaa?ei, Oiiae aeine?aeoAeine?aeaeoaai? iieacieee (iaeeieoe? aei??thaaiiy)NIAe, iae/ia a?eeaEaoaeaca, ieiieue/oa ia a?eea AA, ieiieue/ia oeaieieA-6-OAeA, iiieue /oa ia a?eea A?, iiieue /oa ia a?eea AI, iiieue/oa ia a?eea A-S-T, iiieue/oa ia a?eeaEiio?ieue0,52 0,02189,45 4,177,17 0,099,45 0,143,93 0,1274,06 9,1456,45 1,16Aaiaoeo (1 aeiaa) 0,34 0,01 118,14 0,06 4,03 0,20 6,41 0,29 2,33 0,1 401,35 2,2 29,91 1,683 aeiaa Aaia-oeo 0,38 0,03 131,77 0,6 11,91 0,17 12,91 0,17 4,97 0,1 415,8320,67 39,881,39Aaiaoeo + IAA 0,40 0,02 146,44 7,08 12,41 0,17 11,94 0,24 5,14 0,1 409,24 2,11 45,73 2,747 aeiaa Aaia-oeo 0,41 0,02 141,91 5,36 9,12 0,12 11,20 0.19 4,64 0,13 392 15,66 42,11 2,98Aaiaoeo + IAA 0,49 0,01 171,72 8,14 8,27 0,13 9,54 0,20 4,21 0,17 284,9 9,81 50,65 1,1514 aeiaa Aaia-oeo 0,48 0,02 173,27 6,82 8,23 0,14 9,41 0,24 4,45 0,10 363,14 10,0 45,82 1,86Aaiaoeo + IAA 0,49 0,02 179,25 8,52 7,15 0,27 9,21 0,25 4,01 0,10 280,78 18,51 56,47 1,61 I?ei?oea: * -a??ia?aei? ci?ie aeine?aeaeoaaieo iieaciee?a ii??aiyii c eiio?ieai (?<0,05). Oaaeeoey 5. Ai?no i?iaeoeo?a ia?ieneaeiiai ieeneaiiy e?i?ae?a a ia/?ioe? uo??a ca oiia aenia?eiaioaeueiiai oiene/iiai aaiaoeoo oa ae?? ianoiyiee a?i?ee a??nueei? (IAA) (I±m; n=8-20) A?oie oaa?ei, oiiae aeine?aeoAeine?aeaeoaai? iieacieee (iaeeieoe? aei??thaaiiiy)?IC, A220/ a oeaieieAeE, A232/ a oeaieieEAe ? NO, A278/a oeaieieIAeA, ieiieue/a oeaieieEiio?ieue 37,740,8122,380,5312,860,3239,811,09Aaiaoeo (1 aeiaa)49,882,24 26,210,55 21,840,47 60,433,11 3 aeiaaAaiaoeo58,392,1435,261,23 18,740,26 89,862,67 Aaiaoeo + IAA50,041,0730,151,15 15,320,27 86,343,21 7 aeiaaAaiaoeo51,871,4430,70,84 13,320,27 65,972,94 Aaiaoeo + IAA45,441,12 26,370,8512,810,460,222,03 14 aeiaaAaiaoeo44,022,2626,031,46 12,220,7145,572,38 Aaiaoeo + IAA37,351,5121,621,4812,240,537,882,77 I?ei?oea: * — ?0 a??ia?aei? ci?ie aeine?aeaeoaaieo iieaciee?a ii??aiyii c eiio?ieai (?<0,05) *a?ac o?e aeiae i?ney ?ioieneeaoe?? oaa?ei a e?ia? oa ia/?ioe? inoaii?o niinoa??aaeany iia?e?caoe?y aioeieneaeaioieo nenoai caoenoo (i?aeaeueany ai?no AA, aeoeai?noue A-6-OAeA, A?, AI). Aeoeai?noue A-S-O a ia/?ioe? ?ioieneeiaaieo uo??a caeeoaeany cieaeaiith, i?ioa a ieaci? e?ia? – i?aeaeueeany, ui iiaea aooe iia’ycaii c aeoiaeii oa?iaioo ?c aaiaoioeeo?a a e?ia. Iacaaaeath/e ia iia?e?caoe?th aioeieneaeaioieo ?aca?a?a ee?oeie, ??aaiue i?iaeoeo?a IIE a oeaieiao uo??a ia o?aoth aeiao i?ney ?ioieneeaoe?? i?iaeiaaeoaaa c?inoaoe. O a?oi? oaa?ei, yea io?eioaaea ia oii? i?neyae?? oao?aoei?iaoaio ianoiyieo a?i?ee a??nueei?, iiceoeaia aeeiai?ea uiaei aeine?aeaeoaaieo iieaciee?a IIE i?ine?aeeiaoaaeany aaea ii/eiath/e c o?aouei? aeiae canoinoaaiiy i?aia?aoo. Ai?no iieaeoey?ieo i?iaeoeo?a IIE a aeai?e a?oi? oaa?ei aoa ieae/ei, i?ae o iae?eiaaieo, a aaaaeaiiy ianoiyiee i?ioyaii 14 aei?a ni?eyei iiai?e noaa?e?caoe?? i?ioean?a IIE oa ooieoe?iioaaiiy nenoai aioeieneaeaioiiai caoenoo e?ia? oia/?iee uo??a. Oaeei /eiii, iieacaii, ui ianoiyiea a?i?ee a??nueei? noaa?e?co?, ii?ooaiee ca oiia ieneaeaioiiai no?ano ieneaeaioii-aioeieneaeaioiee aiiainoac oeyoii: 1) aaeueioaaiiy i?ioean?a ia?ieneaeiiai ieeneaiiy e?i?ae?a, iiaeeeai ca ?aooiie ciaioaiiy a oeaieiao eiioeaio?aoe?? aeoeaieo oi?i eenith; 2) aeoeaaoe?? nenoai aioeieneaeaioiiai caoenoo e?ia? oa ia/?iee uo??a; 3) noaa?e?caoe?? ee?oeiieo iaia?ai. AENIIAEE 1. Ieneaeaioiee no?an o uo??a (ae?y iecueeeo aeic ?aae?aoe??, a?iceaii-ae?aceiaa o?aaeaiiy aano?iaeoiaeaiaeueii? ciie, oiene/iee aaiaoeo) noi?iaiaeaeo?oueny nooo?aei iaeiie/aiiyi a oeaieiao oaa?ei ia?aeiieo, i?ii?aeieo oa e?ioeaaeo iieaeoey?ieo i?iaeoeo?a ia?ieneaeiiai ieeneaiiy e?i?ae?a (IIE): niieoe c ?cieueiaaieie iiaea?eieie ca’yceaie, ae??iiaeo eii’thaao?a, eaoiae??i?a ? ni?yaeaieo o?e?i?a, iaeiiiaiai aeeaeueaeaa?aeo. 2. Ii?ooaiiy ieneaeaioii-aioeieneaeaioii? ??aiiaaae a i?aai?ci? uo??a ia 7 aeaiue i?ney iaeii?aciaiai ?o ii?ii?iaiiy a aeic? 0,5 A? oa?aeoa?eco?oueny cieaeaiiyi a e?ia? oa ia/?ioe? ii?ii?iaieo oaa?ei aeoeaiino? noia?ieneaeaeeniooace, eaoaeace, aeooao?iiia?ieneaeace oa aeooao?ii-S-o?ainoa?ace; i?aeaeuaiiyi aeoeaiino? aetheici-6-oinoaoaeaa?ae?iaaiace, aeooao?ii?aaeoeoace, ai?noo a?aeiiaeaiiai aeooao?iio oa oea?oeiieaci?io. 3. Aenia?eiaioaeueia a?iceaii-ae?aceiaa o?aaeaiiy aano?iaeoiaeaiaeueii? ciie oa oiene/iee aaiaoeo noi?iaiaeaeothoueny ?noioi?ie ii?ooaiiyie ooieoe?iioaaiiy nenoai aioeieneaeaioiiai caoenoo: a e?ia? oa ia/?ioe? oaa?ei niinoa??aaeiny ??cea ?o i?eai?/aiiy a ?aii? no?iee oa /anoeiaa a?aeiiaeaiiy o a?aeaeaeai?. 4. Ianoiyiea a?i?ee a??nueei? i?e ae?? ia iaia?aie a?eo?ioeeo?a aeiii??a ca oiia a?iioii?/iiai aaiie?co aeyaey? aeaioaciaee oa?aeoa? ae??: eiioeaio?aoe?? i?aia?aoo, ui a?aeiia?aeathoue 5,21*10-7 – 5,21*10-2 ia a?i?oie?io/100a ianoiyiee i?iyaeythoue ae?aaeaio iaia?aiinoaa?e?coth/o ae?th, a eiioeaio?aoe?? i?aia?aoo aeua 5,21*10-2 ia a?i?oie?io/100a ianoiyiee – aaiie?oe/iee aoaeo. 5. Anoaiiaeaii aioeieneaeaioi? aeanoeaino? ianoiyiee a?i?ee a??nueei?: i?e aaaaeaii? ?? ?ioaeoiei uo?ai a aeic? 0,2 ie/ea iane inoaiiy aaeueio? ia?aa?a i?ioean?a ia?ieneaeiiai ieeneaiiy e?i?ae?a (IIE), i?i ui na?ae/eei ciaioaiiy a e?ia? oa ia/?ioe? uo??a ai?noo aeine?aeaeoaaieo iieaeoey?ieo i?iaeoeo?a IIE. 6. Aaaaeaiiy ?ioaeoiei uo?ai ianoiyiee a?i?ee a??nueei? a aeic? 0,2 ie/ea iane ni?eyei aeoeaaoe?? ooieoe?iioaaiiy nenoai aioeieneaeaioiiai caoenoo e?ia? oa ia/?iee oaa?ei: ca ae?? i?aia?aoo i?aeaeueeany aeoeai?noue noia?ieneaeaeeniooace, eaoaeace, aetheici-6-oinoaoaeaa?ae?iaaiace, aeooao?ii?aaeoeoace, aeooao?iiia?ieneaeace, ai?no aeooao?iio a?aeiiaeaiiai oa oea?oeiieaci?io. 7. Aaaaeaiiy oaa?eiai ianoiyiee a?i?ee a??nueei? ca oiia ieneaeaioiiai no?ano (ae?? iecueeeo aeic ?aae?aoe??, aenia?eiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiy aano?iaeoiaeaiaeueii? ciie oa oiene/iiai aaiaoeoo) i?ioyaii 14 aei?a ni?eyei noaa?e?caoe?? ia?aa?ao i?ioean?a IIE oa ooieoe?iioaaiiy nenoai aioeieneaeaioiiai caoenoo a oeaieiao uo??a. Iniiai? ?iaioe, ui iioae?eiaai? ca oaiith aeena?oaoe?? 1. ss?ai?e ?.I., Iaueoai ?.O., Aieioei I.?., Caoa?/oe O.A. Iaia?aiinoaa?e?coth/a ae?y ianoieee a?i?ee a??nueei?//Oa?iaoe. aeo?i. –1997. –N2. –N.90-93. 2. ss?ai?e ?.I., A?eai?’?aa I.I., Iaueoai ?.O. Aieea ianoieee a?i?ee a??nueei? ia noai ia?ieneaeiiai ieeneaiiy e?i?ae?a oa caoenii? aeooao?iiiai? nenoaie ia/?iee uo??a ca oiia aenia?eiaioaeueiiai oiene/iiai aaiaoeoo//Oe?. aeioei. aeo?i. –1998. –O.70, N2. –N.86-90. 3. ss?ai?e ?.I., A?eai?’?aa I.I. Aioeieneaeaioi? aeanoeaino? ianoiyiee a?i?ee a??nueei?//Iaoeiaee a?niee *a?i?aaoeueeiai oi?aa?neoaoo. –1998. –Aei.20. (A?ieia?y). –N.61-66. 4. ss?ai?e ?.I., Iaueoai ?.O. Aieea ianoiyiee a?i?ee a??nueei? ia ieneaeaioiee noai e?ia?, ia/?iee oa oeoieo uo??a i?e aenia?eiaioaeuei?e ae?aceia?e oai?ia?//A?niee i?iaeai a?ieia?? ? iaaeeoeeie. –1998. –Aei.18. –N.77-79. 5. ss?ai?e ?.I., A?eai?’?aa I.I., Iaueoai ?.O., Einothe E.N. Aieea ianoiyiee a?i?ee a??nueei? ia aeoeai?noue aeayeeo a?ae?ie?oe/ieo oa?iaio?a uo??a ca oiia aenia?eiaioaeueiiai oiene/iiai aaiaoeoo//Oe?. aeioei. aeo?i. –1998. –O.70,N6. –N.88-91. 6. ss?ai?e ?.I., A?eai?’?aa I.I. Aieea ianoiyiee a?i?ee a??nueei? ia noai aioeieneaeaioii? nenoaie e?ia? uo??a i?e aenia?eiaioaeueiiio a?iceaii-ae?aceiaiio o?aaeaii? aano?iaeoiaeaiaeueii? ciie//Iaoeiaee a?niee *a?i?aaoeueeiai oi?aa?neoaoo. –1998. –Aei.20. (A?ieia?y). –N.138-141. 7. Iaueoai ?.O., Aieioei I.?., ss?ai?e ?.I. A?i?ea a??nueea ye e?ea?nueea ?ineeia//Aeai. o AeIOA Oe?. 25.11.95, N2467-Oe95, *a?i?aoe?, 1995. –16n. 8. ss?ai?e ?.I., A?eai?’?aa I.I. Aieea nie?oiai? ianoieee a?i?ee a??nueei? ia noai ia?ieneaeiiai ieeneaiiy aiaeiaaiieo e?i?ae?a//Iaoa??aee iaoeiai? eiioa?aioe?? aeeeaaea/?a, ni?a?ia?oiee?a oa nooaeaio?a i?enay/aii? 120-??//th canioaaiiy *a?i?aaoeueeiai oi?aa?neoaoo (4-6 o?aaiy 1995?.).–O.3.–*a?i?aoe?: ?ooa,1995.–N.63. 9. ss?ai?e ?.I., A?eai?’?aa I.I., Caoa?/oe O.A. Aieea ianoieee a?i?ee a??nueei? ia noai ieneaeaioii? oa aioeieneaeaioii? nenoai e?ia? oa ia/?iee uo??a ca oiia aenia?eiaioaeueiiai aaiaoeoo//Iaoa??aee II Oe?a?inueei? iaoeiai-i?aeoe/ii? eiioa?aioe?? ii ia?iaei?e ? iao?aaeeoe?ei?e iaaeeoeei?. Oace aeiiia?aeae, Aei?i?iiao?ianuee, 1996. –N.96. 10. A?eai?’?aa I.I., ss?ai?e ?.I. Aioeieneaeaioi? aeanoeaino? ianoieee a?i?ee a??nueei? ca oiia ii?ie oa iaoieia??//Iaoa??aee VII Oe?a?inueeiai a?io?i?/iiai c’?caeo (Oace aeiiia?aeae). –E, 1997. –*.III. –N.22-23. 11. ss?ai?e ?.I. Ei?aeoe?y ianoiyieith a?i?ee a??nueei? ii?ooaiue ieneaeaioii-aioeieneaeaioiiai noaoono i?aai?cio uo??a c aenia?eiaioaeueiei a?iceaii-ae?aceiaei o?aaeaiiyi aano?iaeoiaeaiaeueii? ciie//Iaoa??aee 2 i?aeia?iaeiiai iaaee/iiai eiia?ano nooaeaio?a oa iieiaeeo a/aieo 6-8 o?aaiy 1998?. (Oace aeiiia?aeae). –Oa?iii?eue: Oe?iaaeeieaa. –1998. –N.93-94. 12. ss?ai?e ?.I., A?eai?’?aa I.I. Aieea ianoiyiee a?i?ee a??nueei? ia noai aeooao?iiiai? nenoaie uo??a ca oiia iecueeeo aeic ?aae?aoe??//Iaoa??aee III oe?a?inueei? iaoeiai-i?aeoe/ii? eiioa?aioe?? c ia?iaeii? oa iao?aaeeoe?eii? iaaeeoeeie 25-26 aa?aniy 1998?. –O.1. –N.138-139. ss?ai?e ?.I. Ieneaeaioii-aioeieneaeaioiee noai i?aai?cio uo??a ca oiia ieneaeaioiiai no?ano oa ae?? ianoiyiee a?i?ee a??nueei?. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 03.00.04 – a?io?i?y. *a?i?aaoeueeee aea?aeaaiee oi?aa?neoao ?i. TH. Oaaeueeiae/a, *a?i?aoe?, 1999 ??e. A aeena?oaoe?? i?noyoueny aeai? i?i ieneaeaioiee (ia?ieneaeia ieeneaiiy e?i?ae?a) oa aioeieneaeaioiee (ai?no oea?oeiieaci?io, a?aeiiaeaiiai aeooao?iio, aeoeai?noue noia?ieneaeaeeniooace, eaoaeace, aetheici-6-oinoaoaeaa?ae?iaaiace, aeooao?ii-?aaeoeoace, aeooao?iiia?ieneaeace oa aeooao?ii-S-o?ainoa?ace) noai i?aai?cio uo??a ca oiia ieneaeaioiiai no?ano: ae?? iecueeeo aeic ?aae?aoe?? (iaeii?aciaa ii?ii?iaiiy a aeic? 0,5 A?), aenia?eiaioaeueiiai a?iceaii-ae?aceiaiai o?aaeaiiy aano?iaeoiaeaiaeueii? ciie, oiene/iiai aaiaoeoo oa ae?? ianoiyiee a?i?ee a??nueei?. Ca oiia ieneaeaioiiai no?ano iieacaii nooo?a? ii?ooaiiy ieneaeaioii-aioeieneaeaioiiai aiiainoaco (iineeaiiy i?ioean?a ia?ieneaeiiai ieeneaiiy e?i?ae?a, ii?ooaiiy ooieoe?iioaaiiy nenoai aioeieneaeaioiiai caoenoo) oa aioeieneaeaioi? aeanoeaino? ianoiyiee a?i?ee a??nueei?. Eeth/ia? neiaa: ia?ieneaeia ieeneaiiy e?i?ae?a, aioeieneaeaioi? nenoaie, iecuee? aeice ?aae?aoe??, a?iceaii-ae?aceiaa o?aaeaiiy aano?iaeoiaeaiaeueii? ciie, oiene/iee aaiaoeo, uo??, ianoiyiea a?i?ee a??nueei?. ss?aiee E.I. Ieneaeaioii-aioeieneaeaioiia ninoiyiea i?aaiecia e?un a oneiaeyo ieneaeaioiiai no?anna e aeaenoaey ianoieee a?ieee ai?iie. ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 03.00.04.– aeioeiey. *a?iiaeoeeee ainoaea?noaaiiue oieaa?neoao ei. TH. Oaaeueeiae/a, *a?iiaoeu, 1999 aiae. A aeena?oaoeee niaea?aeaony aeaiiua ia ieneaeaioiii (ia?ieneaeiia ieeneaiea eeieaeia) e aioeieneaeaioiii (eiee/anoaa oea?oeiieacieia, aeooaoeiia ainnoaiiaeaiiiai, aeoeaiinoe noia?ieneaeaeeniooacu, eaoaeacu, aetheici-6-oinoaoaeaaeae?iaaiacu, aeooaoeii?aaeoeoacu, aeooaoeiiia?ieneaeacu e aeooaoeii-S-o?ainoa?acu) ninoiyiee i?aaiecia e?un a oneiaeyo ieneaeaioiiai no?anna: aeaenoaea ieceeo aeic ?aaeeaoeee (iaeiie?aoiia iaeo/aiea a aeica 0,5 A?), yenia?eiaioaeueiiai y?iceaii-ycaaiiiai ii?aaeaiey aano?iaeoiaeaiaeueiie ciiu, oiene/aneiai aaiaoeoa e aeaenoaey ianoieee a?ieee ai?iie. Iieacaii, /oi a oneiaeyo aeiioiie/aneiai aaiieeca ieceea eiioeaio?aoeee ianoieee a?ieee ai?iie, niioaaonoaothuea 5,21*10-7–5,21*10-2 ia a?ieoiee-ia/100a ianoieee, noaaeeece?otho eeaoi/iua iaia?aiiu y?eo?ioeeoia, a eiioeaio?aoeee auoa 5,21*10-2 – iaeaaeatho aaiieeoe/aneei yooaeoii. I?iaaaeaiiue a nenoaia in vitro ne?eieia aioeieneaeaioiuo naienoa enneaaeoaiiai i?aia?aoa iieacae, /oi iineaaeiee niiniaai eiaeae?iaaoue eiaeooee?iaaiiia ia?ieneaeiia ieeneaiea yiaeiaaiiuo eeieaeia oaea ia/eiay n eiioeaio?aoeee i?aia?aoa, niioaaonoaothuae 5,21*10-6 ia a?ieoieeia/100a ianoieee, a 50% eiaeae?iaaiea i?ioeannia IIE iaaethaeaeinue i?e eiioeaio?aoeee ianoieee 2,605*10-3 ia a?ieoieeia/100a ianoieee. Neaaeoao caiaoeoue, /oi aieaa /oanoaeoaeueiui e aeaenoaeth i?aia?aoa ieacaeinue oa?iaioaoeaiia (IAAeOI-caaeneiia) IIE, ii n?aaiaieth n iaoa?iaioaoeaiui (anei?aao-caaeneiui). Ia iniiaaiee iieo/aiiuo a nenoaia in vitro aeaiiuo, a oaeaea aeey iiaeoaa?aeaeaiey iineaaeieo auei ?an/eoaii n?aaeianooi/ioth yooaeoeaioth aeico i?aia?aoa e i?iaaaeaii na?eth enneaaeiaaiee in vivo. Niaeanii iieo/aiiui ?acoeueoaoai, oaea /a?ac 12 /ania iinea iaeiie?aoiiai aaaaeaiey eioaeoiui e?unai eco/aaiiai i?aia?aoa a e?iae e ia/aie iineaaeieo nieaeaaony eiee/anoai aeeaiiauo eiiuethaaoia e iiauoaaony aeoeaiinoue aeooaoeiiia?ieneaeacu, a /a?ac 24 /ana – nieaeaiea eiee/anoaa niaaeeiaiee n eciee?iaaiiuie aeaieiuie naycyie, aeeaiiauo eiiuethaaoia, eaoiaeeaiia e nii?yaeaiiuo o?eaiia, iaeiiiaiai aeeaeueaeaaeaea, oaaee/aiea eiioeaio?aoeee oea?oeiieacieia, aeoeaiinoe noia?ieneaeaeeniooacu, eaoaeacu, aetheici-6-oinoaoaeaaeae?iaaiacu, aeooaoeii-?aaeoeoacu, aeooaoeiiia?ieneaeacu. O?iaaiue aeooaoeiia ainnoaiiaeaiiiai i?e yoii aue ieaea, /ai o eioaeoiuo e?un, ii i?e iiaoi?iii aaaaeaiee ianoieee ii?iaeeciaaeny e iaoiaeeeny i?eia?ii ia oaeii o?iaia aei eiioea enneaaeiaaiey. Ieneaeaioii-aioeieneaeaioiue noaoon i?aaiecia e?un, onoaiiaeaiiue /a?ac 24 /ana iinea aaaaeaiey ianoieee nio?aiyeny e i?e aaaaeaiee aa a oeacaiiie aeica aaeaaeiaaii a oa/aiee 3 e 7 aeiae. Iieacaoaee aioeieneaeaioiie nenoaiu e IIE a a?oiia aeeaioiuo iiaeaa?aoeony aeeeoaeueiiio aaaaeaieth i?aia?aoa (aaeaaeiaaii a oa/aiea 14 aeiae) i?aeoe/anee ia ioee/aeenue io iieacaoaeae eiio?iey. Ieneaeaioiue no?ann o e?un (aeaenoaea ieceeo aeic ?aaeeaoeee, yenia?eiaioaeueiia y?iceaii-ycaaiiia ii?aaeaiea aano?iaeoiaeaiaeueiie ciiu, oiene/aneee aaiaoeo) nii?iaiaeaeathony nouanoaaiiuie ia?ooaieyie ieneaeaioii-aioeieneaeaioiiai aiiainoaca. Ia 7 nooee iinea iaeiie?aoiiai ?aioaaiianeiai iaeo/aiey e?un a aeica 0,5 A? a e?iae e ia/aie aeeaioiuo iaaethaeaaony oaaee/aiea ia?ae/iuo, i?iiaaeooi/iuo e eiia/iuo i?iaeoeoia IIE, a oaeaea aeeneii?aeeiaoeey a ooieoeeiie?iaaiee nenoai aioeieneaeaioiie caueou: nieaeaiey aeoeaiinoe noia?ieneaeaeeniooacu, eaoaeacu, aeooaoeiiia?ieneaeacu, oaaee/aiea eiee/anoaa oea?oeiieacieia, aeooaoeiia ainnoaiiaeaiiiai e aeoeaiinoe oa?iaioia, i?eieiathueo iaiin?aaenoaaiiia o/anoea a ?aaaia?aoeee aai ec ieeneaiiie oi?iu (aetheici-6-oinoaoaeaaeae?iaaiaca, aeooaoeii?aaeoeoaca). Aaaaeaiea aeeaioiui ianoieee a?ieee ai?iie a oa/aiee 7 aeiae iinea iaeo/aiey niinianoaiaaei oeo/oaieth enneaaeoaiuo iieacaoaeae a e?iae e ia/aie e?un. A a?oiia aeeaioiuo i?eieiaaoeo ianoieeo a oa/aiea 7 aeiae aei e 7 aeiae iinea iaeo/aiey ana enneaaeoaiua iieacaoaee ia ioee/aeenue io iieacaoaeae eioaeoiuo aeeaioiuo. Yenia?eiaioaeueiia y?iceaii-ycaaiiia ii?aaeaiea aano?iaeoiaeaiaeueiie ciiu o e?un nii?iaiaeaeaaony nouanoaaiiui oaaee/aieai a noaieao aeaeoaeea, e?iae e ia/aie e?un iieaeoey?iuo i?iaeoeoia IIE. I?ioeann ycaiia?aciaaiey nii?iaiaeaeaaony oaaee/aieai eiioeaio?aoeee oea?oeiieacieia, aeoeaiinoe aeooaoeiiia?ieneaeacu e aeooaoeii?aaeoeoacu; nieaeaieai aeoeaiinoe noia?ieneaeaeeniooacu, eaoaeacu, aetheici-6-oinoaoaeaaeae?iaaiacu, o?iaiy aeooaoeiia ainnoaiiaeaiiiai a e?iae e ia/aie e?un. Aeoeaiinoue aeooaoeii-S-o?ainoa?acu auea i?e yoii nieaeaia a ia/aie e oaaee/aia a ieacia e?iae e?un. Aaaaeaiea aeeaioiui ianoieee a?ieee ai?iie niinianoaiaaei aieaa auno?ie ii?iaeecaoeee enneaaeoaiuo iieacaoaeae a oeaiyo e?un, a 14-aeiaaiia aa i?eiaiaiea i?eaaei e eo iieiie ii?iaeecaoeee. Ii?aaeaiea ia/aie /aou?aooei?enoui oaea?iaeii aucuaaao cia/eoaeueiia iaeiieaiea a ia/aie e e?iae e?un anao enneaaeoaiuo iieaeoey?iuo i?iaeoeoia IIE, a oaeaea ?aceia oaiaoaiea anao aioeieneaeaioiuo nenoai caueou (e?iia aeoeaiinoe aeooaoeiiia?ieneaeacu) a ?aiiea n?iee iinea eioieneeaoeee (/a?ac nooee iinea iineaaeiaai aaaaeaiey oao?aoei?iaoaia) e /anoe/iia eo ainnoaiiaeaiea a ioaeaeaiiua (ia 7 e 14 nooee). I?eiaiaiea ianoieee a?ieee ai?iie ia oiia iineaaeaenoaey /aou?aooei?enoiai oaea?iaea niinianoaoao oeo/oaieth enneaaeoaiuo iieacaoaeae a e?iae e ia/aie e?un, a aeaooiaaeaeueiia aa eniieueciaaiea – eo iieiie ii?iaeecaoeee. Eeth/aaua neiaa: ia?ieneaeiia ieeneaiea eeieaeia, aioeieneaeaioiua nenoaiu, ieceea aeicu ?aaeeaoeee, y?iceaii-ycaaiiia ii?aaeaiea aano?iaeoiaeaiaeueiie ciiu, oiene/aneee aaiaoeo, e?unu, ianoieea a?ieee ai?iie. Yaremiy I.M. Oxidant-antioxidant state of rats’ organism in condition of an oxidant stress and the influence of Arnica montana tincture. Manuscript. Thesis for the competition of a scientific degree of the Candidate of Biological science on the speciality 03.00.04 – Biochemistry. Chernivtsi State University named after Y. Fedkovych, Chernivtsi, 1999. The present thesis is proposed to be defended for the competition of scientific degree of the Candidate of Biological science, the main principles of which were stated in 15 scientific publications. The thesis contains date about oxidant (lipid peroxidation) and antioxidant (the level of caeruloplasmin, reduced glutathione, the activity of superoxide dismutase, catalase, glucoso-6-phosphate dehydrogenase, glutathione reductase, glutathione peroxidase and glutathione-S-transferase) state of rats’ organism in conditions of oxidant stress: low dose of irradiation (single irradiation in a dose of 0,5 Gr), experimental erosive-ulcer affection of the gastroduodenal area, toxic hepatitis and the influence of Arnica montana tincture. In condition of an oxidant stress substantial disorder of oxidant-antioxidant homeostasis (incrising the level of lipid peroxidation products and disorder in antioxidant system) in the liver and blood of rats and antioxidant properties of Arnica montana tincture were established. Key words: lipid peroxydation, antioxydant sestems, low dose of irradiation, erosive-ulser affection of the gastroduodenal area, toxic hepatitis, rats, Arnica montana tincture.

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