EUeA?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?i. AeAIEEA AAEEOeUeEIAI

OAeE 616.314-002-053.4/6-092: 612.014.469:546.22

E?OIIEE IAOAE?ss IEEIEA?AIA

IAY?OIOOAAIIss I?IO?EAEOEEE EA???NO

COA?A O Ae?OAE, ssE? I?IAEEAATHOUe O

?AY?II? N??*AIIAI AE?IAIEOeOAA

14.01.22 — NOIIAOIEIA?ss

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

EUeA?A — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

?i. Aeaieea Aaeeoeueeiai IIC Oe?a?ie

Iaoeiaee ea??aiee:Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani?

Niiey? I?ia ?aai?aia,

caa?aeoaa/ eaoaae?e noiiaoieia?? aeeoy/iai a?eo Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Ae. Aaeeoeueeiai IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?

Aee/ei ?aaai Ieeeoi?iae/,

caa?aeoaa/ eaoaae?e noiiaoieia?? aeeoy/iai a?eo Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? IIC Oe?a?ieaeieoi? iaaee/ieo iaoe,
i?ioani?

Caaieioiee Oa?an Aeieo?iae/,

caa?aeoaa/ eaoaae?e oa?aiaaoe/ii? noiiaoieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i. Ae. Aaeeoeueeiai IIC Oe?a?ie

I?ia?aeia onoaiiaa:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. aeaae. I. I. Aiaiiieueoey IIC Oe?a?ie, eaoaae?a aeeoy/i?
oa?aiaaoe/ii? noiiaoieia??

Caoeno a?aeaoaeaoueny “ 11 ” o?aaiy 1999 ?. i 13. 00 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.600.01 o Euea?anueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? ?i. Aeaieea Aaeeoeueeiai (290010, i. Euea?a,
aoe. Iaea?nueea, 69)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai (290010,
i. Euea?a, aoe. N?/iaeo No??eueoe?a, 6)

Aaoi?aoa?ao ?ic?neaiee “ 9 ” ea?oiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
*oee?i N.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

No?oeoo?a oaeoi??a, ye? aieeaathoue ia caei?ia’y ianaeaiiy, a oiio /ene?
? aeeoy/iai, ia? nooo?aa cia/aiiy ? aeey oi?ioaaiiy noiiaoieia?/iiai
caei?ia’y [Aeaenaaa N. A. e niaao., 1993; Aiae?ooeaae/ E. A. e niaao.,
1988; Iiaee I.A., 1989; Niiey? I.?., I?eoei C.?.,1993; Nieieia A. E.,
1984; Nooaeaieei I. ss. e niaao., 1989; Baranska-Grachovska M. et al. ,
1986; Cikrt V. et al., 1983; WHO, 1992]. Aieea ia noai caei?ia’y ae?oae
cae?enith?oueny iaeii/anii aaaaoueia oaeoi?aie (aio?iiiaaiieie,
iaaeeei-a?ieia?/ieie, nioe?aeueieie), a nooi?iue ?o ae?? caeaaeeoue a?ae
?iaeea?aeoaeueieo iniaeeainoae i?aai?cio, niaaeeiaeo aaeaioaoe?eieo
oaeoi??a [Cieioa?aaa I.A., Iao?ia A. A., 1992; Eoeaeia A. e niaao.,
1993; Lalas D., 1993; WHO, 1980].

Iaaieiia c?inoaiiy caa?oaeiaiiy iaaeieeoiueiai na?aaeiaeua iai?ee?ioe?
OO noie?ooy i?ecaaei aei cia/iiai ii?ooaiiy aeieia?/ii? ??aiiaaae o
nenoai? ethaeeia — aeiae?eey. I?ae aieeaii iecee /eiiee?a
iaaeieeoiueiai na?aaeiaeua o ianaeaiiy, a ia?oo /a?ao aeeoy/iai,
aeieeathoue ??ciiiai?oi? ?ioiiaeao?oeeoi? noaie, niinoa??aa?oueny
cieaeaiiy niaoeeo?/ieo ? ianiaoeeo?/ieo caoenieo nee i?aai?cio, ui
ni?ey? c?inoaiith caoai?thaaiino?, a oiio /ene? ? noiiaoieia?/ii?
[Aaeueoeuaa TH.A., 1991; Aeaoeaiei ?. ?., 1993; Eocueieia Y. I. E
niaao., 1996; Eaooiia N. A., 1986; Neaei?aiei A. E., Iiaeaaa A. A.,
1987; Driessens F. et al., 1989; Mushak E.W., Piver W.T., 1992 ; WHO,
1992;].

O?i?/i? a?aioe, a oiiaao o?eaaei? ae?? a iaeeo eiioeaio?aoe?yo, e??i
caeaoiino? ni?e/eiyoe ianiaoeeo?/i? caoai?thaaiiy, iiaeooue aeeeeeaoe
iani?eyoeea? iane?aeee ye na?aae iei?oiueiai iieie?iiy, oae ? na?aae
eiai iauaaee?a [Aiiaoaaneay O. E., 1978; Eaaeoaa A. A., 1989; Eoeaeia A.
e niaao., 1993]. Ca aeaieie AIIC, oaea nueiaiaei? a?ey /ioe?ueio
a?aenioe?a iiaiia?iaeaeaieo a?ae??ciythoueny aaiaoe/ieie aeaoaeoaie,
ye? aeae? aaaeooue aei ae?aaeaieo niaaeeiaeo caoai?thaaiue. C’yniaaii,
ui caaaeueia caoai?thaai?noue ae?oae o caa?oaeiaieo ?a??iiao a 1,5 — 3
?ace aeua, i?ae o ii??aiyii /enoeo, e?euee?noue ae?oae, ye? /anoi
oai??thoue noaiiaeoue 67-77 %. O no?oeoo?? niiaoe/ieo caoai?thaaiue
ia?aaaaea? iaoieia?y i?aai?a aeeoaiiy, ui iia’ycaii ?c niaoeeo?/iith
ae??th iiethoaio?a aoiinoa?e ia aeeoaeueio nenoaio [Aeaauaeia A.I. e
niaao., 1992; Aeaooia O.O., 1981; Ceaoaa N.I. e niaao., 1993; Duxburry
J.T, 1987; Sohlotcke S. et al., 1984; Tardiff R.G. et al., 1987].
Aenieith ? /anoea aea?a?/ieo caoai?thaaiue, iniaeeai a?iio?aeueii?
anoie. I?ioa ae?aiacii niiaoe/ii? iaoieia??, aeeeeeaiee aieeaii
aio?iiiaaiieo /eiiee?a, cia/ii oe?oee ? aeeth/a? cia/i? ci?ie c aieo
oeaio?aeueii? oa ia?eoa?e/ii? ia?aiai? nenoaie, iii?ii-?ooiaiai
aia?aoo, aiaeie?eiii? nenoaie oa i?aai?a e?iaioai?aiiy, e?iaiia?ao,
o?aaeaiiy [Eiceiaoe A.E., 1990; Onoeiaiei A.I. e niaao., 1990; TH?ueaaa
Y.A. e niaao., 1991]. Eeoa 40 % ae?oae caei?iaeie cae?i/othoue oeieo.

I/aaeaeiei ? nooo?aee aieea i?e?iaeieo ? oaoiiaaiieo /eiiee?a ? ia
noiiaoieia?/ia caei?ia’y aeeoy/iai ianaeaiiy [Aeu/ei A.I. e niaao.,
1988; Eacaeiaa ?.A., 1996]. Aeine?aeaeaii, ui aieea oe?aeeeaeo oaeoi??a
aeiae?eey coiiaeth? iaiiaiioe?ii?noue no?oeoo?e oaa?aeeo oeaiei coa?a
ua a ia??iae ?o ?icaeoeo.

Iioe?ai?noue ea???no coa?a o ae?oae, ye? iaoeathoue ia caa?oaeiaieo
oa?eoi??yo, a ie?aieo a?eiaeo a?oiao neeaaea? 33,8-96,7 %, a o aeayeeo
?a??iiao aeinyaa? 100 %. ?ioaineai?noue ea???no o 12-oe ??/ieo ae?oae,
ye? ia?aaaaeii oa?aeoa?ecothoueny aenieei nooiaiai aaeaioiaaiino? ii
noiiaoieia?/ieo caoai?thaaiiyo, nyaa? 4,570,38-7,240,40 coaa.
Caoai?thaai?noue a?iiieac??th aiae? coa?a eieeaa?oueny a iaaeao 6,47 —
62,2 %, ?iciianthaeaeai?noue neiioii?a caoai?thaaiue ia?iaeiioa
aeyaey?oueny o 14,3 — 77,2 %, ??aaiue coai-uaeaiieo aiiiae?e
eieeaa?oueny a iaaeao 47,53 — 59,98 % [AEoiaoia O., 1988; Iao?ao I.A.,
Iao?ao TH.?., 1995; Neey? A.A. e niaao., 1989; Nieiiueei A.I., 1997;
Oiiaiei E.I. ? ni?aaao., 1995].

I?ioa, iacaaaeath/e ia ?ic?iaeo oa ai?iaaaeaeaiiy cia/ii? e?eueeino?
??cieo cania?a ? iaoiae?a i?io?eaeoeee noiiaoieia?/ieo caoai?thaaiue,
a?ae/ooieo iiceoeaieo ci?i o caoai?thaaiino? na?aae aeeoy/iai ianaeaiiy
Oe?a?ie ia niinoa??aa?oueny.

Ia?aeaeueii c oeei, io?oe?ei? aeai? AIIC, ca?oa?aei? aeaea?aea
e?oa?aoo?e na?ae/aoue i?i ?aaeuei? oni?oe o ai?iouea? c ea???nii oa
caoai?thaaiiyie ia?iaeiioa [Bibby B.G. at al., 1980; Bruun C. et al. ,
1994; Disney J., 1992; Ismail A.L. et al., 1987; King J.M. et al.,
1983; WHO, 1987]. Ai?iaaaeaeaiiy i?ia?ai i?io?eaeoeee iniiaieo
noiiaoieia?/ieo caoai?thaaiue aaco?oueny ia aeaoaeueiiio aeine?aeaeaii?
aeciaaieo oa aiaeiaaieo /eiiee?a, ui aieeaathoue ia oi?ioaaiiy iaoieia??
oaa?aeeo oeaiei coa?a na?aae aeeoy/iai ianaeaiiy a iaaeao eiie?aoiiai
?a??iio, iiaaae?ieiaeo aniaeoao ii a?aeiioaiith aei noiiaoieia?/iiai
caei?ia’y c aieo ianaeaiiy, iaaee/iiai ia?niiaeo, i?aoe?aiee?a
iaa/aeueieo caeeaae?a, nooaeaio?a [Goren A. et al., 1991; Hyssala L. et
al., 1991; Jackson D., 1987; Tala H., 1984].

Nueiaiaei?, i?eioeeiia? ieoaiiy o?aaeaiiy coa?a ea???nii, c o?aooaaiiyi
?a??iiaeueieo iniaeeainoae, aena?oeththoueny a e?oa?aoo??, aea
caeeoathoueny aeaeaeeie a?ae inoaoi/iiai ae??oaiiy i?iaeai
i?io?eaeoeee. A?aenooi?noue ocaaaeueithth/eo aeine?aeaeaiue c ieoaiue
?a??iiaeueiiai iioe?aiiy ea???no coa?a, ni?e/eieea aei iiaiiai
a?aenoaaaiiy iaoeiaeo ii?aoethaaiue a?ae ?aaeueieo iio?aa i?aeoe/ii?
noiiaoieia??. E??i oiai, iaaeinoaoi? iciaeiieaiiy e?ea??a c
iniaeeainoyie ?a??iiaeueii? i?io?eaeoeee ea???no coa?a, a?aenooi?noue
o?iainoaaiiy ? aieiaieie i?e/eiaie iacaaeia?eueieo ?? ?acoeueoao?a
[Eacaeiaa ?.A., Eieueoeiaa I.E. , 1996; Niiey? I.E., 1987].

C iaeyaeo ia aeuacaaaeaia, noa? i/aaeaeiith neeaaei?noue ?
aaaaoia?aii?noue i?iaeaie aieeao ??ciiiai?oieo oaeoi??a ia ??ai?
noiiaoieia?/ii? caoai?thaaiino? ae?oae, iaiao?aei?noue ?ic?iaee
eiiieaeno i?io?eaeoe/ieo caoiae?a, ye? a a?aoiaoaaee ?a??iiaeuei?
iniaeeaino?.

Ioaea, aea/aiiy no?oeoo?e i?e/eiii-iane?aeeiaeo ca’yce?a aeieeiaiiy oa
?icaeoeo ea???no coa?a o ae?oae, eiai ?iciianthaeaeaiino?, iniaeeainoae
ee?i?/iiai ia?aa?ao c o?aooaaiiyi aeieia?/iiai oiio ie?aiiai ?a??iio ?
aeooaeueiith i?iaeaiith no/anii? noiiaoieia??, ooiaeaiaioii aeey
noai?aiiy eiiieaenii? i?ia?aie i?io?eaeoeee.

Oiio, aeeeaaeai? aeua iieiaeaiiy, noaee iniiaith aeey aeai?o oaie
aeaiiai aeine?aeaeaiiy, eiai iaoe oa caaaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?y aeeiiaia ca?aeii c ieaiii IAe? eaoaae?e noiiaoieia??
aeeoy/iai a?eo Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.
Ae. Aaeeoeueeiai ’’ Ioe?iea ?eceeo aeieeiaiiy ea???no coa?a oa
caoai?thaaiue ia?iaeiioa o ae?oae c iaoieia??th aioo??oi?o i?aai?a, ui
i?iaeeaathoue a aeieia?/ii iani?eyoeeaeo ?a??iiao ’’, ? Aea?ae.
?a?no?aoe?? 0196V013962.

Iaoa ? caaea/? aeine?aeaeaiiy.

Ia iniia? aea/aiiy iniaeeainoae oi?ioaaiiy ea??iciiai i?ioeano, noaio
oaa?aeeo oeaiei coa?a oa iniaeeainoae ee?i?/iiai ia?aa?ao caoai?thaaiiy
o ae?oae, ye? i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa ?ic?iaeoe
aoaeoeaiee eiiieaen i?io?eaeoe/ieo caoiae?a, aaeaioiaaiee aeey ae?oae
aeine?aeaeoaaiiai ?a??iio.

Iaoith aeine?aeaeaiiy aecia/ai? ianooii? caaea/?:

1. Aea/eoe ?iciianthaeaeai?noue oa ?ioaineai?noue o?aaeaiiy coa?a
ea???nii, c’ynoaaoe iniaeeaino? eiai ee?i?/iiai ia?aa?ao a caeaaeiino?
a?ae a?eo, o ae?oae, ui iaoeathoue o ?a??ii? n??/aiiai ae?iaieoeoaa.

2. Ioe?ieoe a?a??i?/iee noai ?ioiai? ii?iaeieie, ??aaiue
nai?oa?ii-a?a??i?/ieo ciaiue o ianoaaeaieo ae?oae oa ?o ca’ycie c
?icaeoeii ea???no coa?a.

3. Aeine?aeeoe oa ioe?ieoe i?ia?ae?coth/o caeaoi?noue ci?oaii? neeie
oa ?? ?ioiieia?/i? iieacieee a ianoaaeaieo ae?oae, ye e?eoa???
aaeaioaoe?? aei aieeao /eiiee?a aeiae?eey.

4. Aea/eoe i?e?iaei? oa oaoiiaaii? oaeoi?e iaaeieeoiueiai na?aaeiaeua
ia oa?eoi??? n??eiiinii? aaii?ia?ioe?? oa ia??oiooaaoe ?o aieea ia
?icaeoie ea???no coa?a o ae?oae.

5. ?ic?iaeoe oa ioe?ieoe aoaeoeai?noue eiiieaeno i?io?eaeoe/ieo
caoiae?a, c o?aooaaiiyi aeciaaiieo oa aiaeiaaieo oaeoi??a, yeee ae
ni?eya cieaeaiith o?aaeaiino? coa?a ea???nii o ae?oae, ui i?iaeeaathoue
o n??eiiini?e aaii?ia?ioe??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa aea/aii o?aaeai?noue coa?a ea???nii, iniaeeaino? eiai ee?i?/iiai
ia?aa?ao oa ??aaiue nai?oa?ii-a?a??i?/ieo ciaiue ? iaae/ie, noai a?a??ie
ii?iaeieie ?ioa o ae?oae, ui iaoeathoue o n??eiiini?e aaii?ia?ioe??.
Aeine?aeaeaii aca?iica’ycie i?ae aiaeiaaei iieacieeii, a’yce?noth oa
ai?noii eaeueoe?th o ci?oai?e neei? oa anoaiiaeaii ?o i?i?iinoe/ia
cia/aiiy aeey aecia/aiiy aaaeeino? ia?aa?ao ea??iciiai i?ioeano o ae?oae
c ?a??iio aeiaoaaiiy n??ee. Aia?oa ca ?acoeueoaoaie aea/aiiy
i?e?ie?enoae?caoe?? ci?oaii? neeie i?iaaaeaii ioe?ieo i?ia?ae?coth/iai
iioaioe?aeo neeie ca aaeueiith nenoaiith o ae?oae, ye? i?aeaeathoueny
cia/iiio aio?iiiaaiiiio iaaaioaaeaiith oa ia??oioiaaii iiaeeeaa ?o
canoinoaaiiy o i?iaiicoaaii? ea???no coa?a ? aeey ioe?iee aoaeoeaiino?
i?io?eaeoeee. Aeine?aeaeaii ai?no ?ioii?eiaoe?i?a o ci?oai?e neei?
ae?oae, ye? i?iaeeaathoue o ?a??ii? n??eiaeaeiaoaiiai eiiieaeno, a
caeaaeiino? a?ae nooiaiy aeoeaiino? ea???no coa?a. Aia?oa aeyaeaii e
i?iaiae?ciaaii /eiieee aeiae?eey ?a??iio n??/aiiai ae?iaieoeoaa, ye?
ni?eythoue aeieeiaiith ea???no coa?a o ae?oae oa iaoyaeothoue eiai
ee?i?/iee ia?aa?a.

Aia?oa ?ic?iaeaii oa ai?iaiaaii eiiieaen caoiae?a aeey i?io?eaeoeee
ea???no coa?a o ae?oae, ui i?iaeeaathoue o ?a??ii? n??/aiiai
ae?iaieoeoaa c o?aooaaiiyi aeieia?/ieo iniaeeainoae aeaiiai ?a??iio,
yeee aeeth/a? a?iaaii? noeioeyoi?e.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

I?aeoe/ia cia/aiiy iaoeiaeo iieiaeaiue ? aeena?oaoe?eieo aeniiae?a
iieyaa? o iiaeeeaino? aeei?enoaiiy ?ioi?iaoe?? i?i o?aaeai?noue coa?a
ea???nii o ae?oae, ui i?iaeeaathoue o n??eiiini?e aaii?ia?ioe??,
i?aaiaie i?aeoe/ii? noiiaoieia?? aeey ieaioaaiiy ooao?a aeeoy/eo
noiiaoieia?a, ?ic?iaee ?a??iiaeueieo i?ia?ai i?io?eaeoeee ea???no coa?a,
ioe?iee noaio noiiaoieia?/ii? aeiiiiiae ae?oyi.

Cai?iiiiiaai? e?eoa??? ioe?iee i?ia?ae?coth/i? caeaoiino? ci?oaii?
neeie, ye? ? ?ioi?iaoeaieie aeey aecia/aiiy ea???niaaiii? neooaoe?? a
?ioia?e ii?iaeiei?, aeicaieythoue i?iaiicoaaoe ?icaeoie ea??iciiai
i?ioeano, ioe?ithaaoe aoaeoeai?noue cae?enithaaii? ea???ni?io?eaeoeee,
ia iio?aaothoue niaoe?aeueiiai iaeaaeiaiiy ? ? aeinooiieie aeey
aeeiiaiiy a oiiaao noiiaoieia?/ieo iie?ee?i?e ? noiiaoieia?/ieo
eaa?iao?a oe?e ? aeioe?eueieo caeeaae?a.

Ii?aoeueiaaii oa ?aeiiaiaeiaaii eiiieaen caoiae?a ii i?io?eaeoeoe?
ea???no coa?a, aaeaioiaaiee aeey ae?oae, ui i?aeaeathoueny aieeaia?
oe?aeeeaeo i?e?iaeieo ? oaoiiaaiieo /eiiee?a, c aeei?enoaiiyi
a?inoeioeyoi??a ’’A?io?eo N’’ oa ’’A?iaeaio-2’’, ?ic?iaeaieo Iaeanueeei
IAe? noiiaoieia?? oa iaoeiai-ae?iaie/ei ia’?aeiaiiyi ’’Iaeanueea
a?ioaoiieia?y’’, i?aia?ao?a eaeueoe?th oa ooi?o, ui noaa?e?cothoue
caoeni? nenoaie i?aai?cio aeeoeie c o?aooaaiiyi nooiaiy o?aaeaiino?
coa?a ea???nii.

?acoeueoaoe aeine?aeaeaiue c iiceoeaiei aoaeoii ai?iaaaeaeaii o
i?aeoe/io ae?yeuei?noue ia ?a??iiaeueiiio oa iaeaniiio ??aiyo, a
noiiaoieia?/ieo onoaiiaao i. Eueaiaa, a oaeiae o noiiaoieia?/ieo
iie?ee?i?eao Oa?iii?euenueei? oa Caea?iaonueei? iaeanoae.

Iniiai? iaoeia? iieiaeaiiy aeena?oaoe?? aeeth/ai? aei eaeoe?eiiai
iaoa??aeo oa aeei?enoiaothoueny i?ae /an i?aeoe/ieo caiyoue c?
nooaeaioaie ia eaoaae?ao noiiaoieia?? aeeoy/iai a?eo Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Ae. Aaeeoeueeiai, Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo oa Aeiiaoeueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai, o oeeee? oaeoeueoaoo
aaeineiiaeaiiy aeeoy/eo noiiaoieia?a i?e eaoaae?? noiiaoieia?? aeeoy/iai
a?eo Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Ae.
Aaeeoeueeiai.

Iniaenoee aianie caeiaoaa/a

Aeena?oaoe?eia ?iaioa ? caaa?oaiei iaoeiaei aeine?aeaeaiiyi I. I.
E?oi- iee. Aaoi? iinoaaeea iaoo oa caaaeaiiy iaoeiai?
?iaioe, iiaioaaea oa aeeiiaea iaiao?aei? iaoiaeeee aeine?aeaeaiiy,
noi?ioaaea ee?i?/i? a?oie ae?oae. Ee?i?/ia ianoaaeaiiy ae?oae,
aeine?aeaeaiiy i?ia?ae?coth/i? caeaoiino? oa ?ioiiiai oiio ci?oaii?
neeie, aiae?c oa ?ioa?i?aoaoe?y aeaieo ee?i?ei-eaai?aoi?ieo
aeine?aeaeaiue cae?eniaia naiino?eii. Aeeeaaeai? o aeena?oaoe?? iaoeia?
iieiaeaiiy oa aeniiaee noi?ioeueiaai? aaoi?ii naiino?eii.

Ni?aaaoi?noai ?ioeo aeine?aeiee?a o 10 c 16 iaoeiaeo ?ia?o,
iioae?eiaaieo ca iaoa??aeaie aeena?oaoe??, caeaa?eueoiai a?aeaeca?eaeth?
?o eiinoeueoaoeaio aeiiiiiao, ni?ao/anoue o eaai?aoi?ieo aeine?aeaeaiiyo
oa /anoeiai o oaenoiaiio aeeeaae? io?eiaieo ?acoeueoao?a aeine?aeaeaiue.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iniiai? iieiaeaiiy aeaiiai aeine?aeaeaiiy i?aaenoaaeai? oa iaaiai?ai? ia
IV eiioa?aioe?? PST ‘‘ Postepy w stomatologi?. Nie konwencjonalne metody
lecznenia‘‘ (i. Iiciaiue, Iieueoa, 1995); Anaoe?a?inuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? e?ea??a-noiiaoieia?a (i. Iieoaaa, 1996);
Ia?o?e Anaoe?a?inuee?e eiioa?aioe?? ‘‘Oai?aoe/i? oa i?eeeaaei? aniaeoe
nioe?iaeieia??‘‘ (i. Euea?a, 1996); iaoeiai-i?aeoe/i?e eiioa?aioe??
e?ea??a-noiiaoieia?a Cao?aeiiai ?a??iio Oe?a?ie (i. Euea?a, 1997);
i?aeia?iaei?e eiioa?aioe?? ‘‘ Fogarty International Center Environmental
Research Forum‘‘ (i. Euea?a, 1997); i?aeia?iaei?e eiioa?aioe??
‘‘Profilaktyka i biomaterialy w stomatologii‘‘(i. Iic-iaiue, Iieueoa,
1997); Ia?aae? ea??aiee?a noiiaoieia?/ieo neoaea ?a?iiaenueeeo e?a?i —
Council of European Chief Dental Officers, 11-th Autamn Meeting
(i. Aa?oaaa, Iieueoa, 1997); iaoeiai-i?aeoe/i?e eiioa?aioe?? «Iaaee/i?
oa aeieia?/i? i?iaeaie *a?aiiia?aaenueeiai ?a??iio‘‘(i. *a?aiiia?aae,
Euea?anueea iaeanoue, 1998); i?aeia?iaei?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? ’’E?eciaee oa ia?aaee?eciaee noai aeiae?eey, ye ?acoeueoao
oaoiiaaiiiai aieeao ia aaieia?/ia na?aaeiaeua ? aaiii?oinoa?o’’ (i.
Euea?a, 1998 ), 76-?e Yaia?aeuei?e Nan?? Anana?oiuei? anioe?aoe??
noiiaoieia?/ieo aeine?aeaeaiue — 76th General Session and Exibiton of
IADR, (i. I?oea, O?aioe?y, 1998); 77-?e Yaia?aeuei?e Nan??
Anana?oiuei? anioe?aoe?? noiiaoieia?/ieo aeine?aeaeaiue — 77th General
Session of IADR, (i. Aaieoaa?, Eaiaaea, 1999).

Ioae?eaoe??

Ii oai? aeena?oaoe?? iioae?eiaaii 16 ae?oeiaaieo i?aoeue (a o./. 3 — o
iaoeiaeo aeo?iaeao, 6 — o ca??ieeao iaoeiaeo i?aoeue, 7 — o iaoa??aeao ?
oacao eiioa?aioe?e).

No?oeoo?a oa ianya aeena?oaoe??

Aeena?oaoe?y neeaaea?oueny c? anooio, aeaa’yoe ?icae?e?a, aeniiae?a,
nieneo aeei?enoaieo e?oa?aoo?ieo aeaea?ae ? aeaio aeiaeaoe?a: A —
’’Ea?oa ianoaaeaiiy ii?iaeieie ?ioa aeeoeie’’; A — eii?? aeo?a
ai?iaaaeaeaiiy. Iiaiee ianya aeena?oaoe?? neeaaea? 203 noi??iee. ?enoiee
(20), oaaeeoe? (37), aeiaeaoee (8) oa nienie aeei?enoaieo e?oa?aoo?ieo
aeaea?ae (332 a?ae?ia?ao?/ieo aeaea?aea) caeiathoue 92 noi??iee.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy

Aeey ae??oaiiy iinoaaeaii? iaoe aoei i?iaaaeaii ee?i?/ia ianoaaeaiiy
1502 ae?oae, na?aae yeeo 867 ae?oae, ye? ia?iaeeeenue ? i?iaeeaathoue o
?a??ii? n??/aiiai ae?iaieoeoaa (iniiaia a?oia). Eiio?ieueio a?oio neeaee
635 i?aeoe/ii caei?iaeo ae?oae, iaoeaioe?a i?noa Eueaiaa.

Ca?aeii ?aeiiaiaeaoe?? ii noaiaea?oecaoe?? noiiaoieia?/ieo caoai?thaaiue
AIIC (1981), i?iaaaeaii ?iciiae?e ae?oae ? aeae?eaii eeth/ia? a?oie — 3,
6, 9, 12 ?ie?a. Ia eiaeio aeeoeio caiiaithaaee ?ic?iaeaio ia eaoaae??
noiiaoieia?? aeeoy/iai a?eo Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?noeoaoo ’’Ea?oo ianoaaeaiiy ii?iaeieie ?ioa aeeoeie’’.

Aeey aecia/aiiy o?aaeaiino? coa?a ea???nii o ae?oae aeei?enoiaoaaee
iieacieee: iioe?ai?noue (a %) oa ?ioaineai?noue (ca ?iaeaenaie ei oa EIA
coa?a ? ii?iaeiei). ?iciianthaeaeai?noue oa ?ioaineai?noue ea???no
i?iaiae?ciaaii ie?aii aeey iiei/ieo ? iino?eieo coa?a.

?iaeea?aeoaeueiee ??aaiue ?ioaineaiino? ea???no (??E) ye aeey iiei/ieo,
oae ? iino?eieo coa?a aecia/aee ca?aeii ?aeiiaiaeaoe?e I. A. Eaona
(1992). Ae?oae eiaeii? a?eiai? ??aaeaoe?? aoei ?iciiae?eaii a?aeiia?aeii
aei aeoeaiino? ea???no ca iaoiaeeeith O. O. Aeiia?aaeiai? (1978) o
iiaeeo?eaoe?? I. ?. Niiey? ? ni?aaaoi??a (1981).

??aaiue noiiaoieia?/ii? aeiiiiiae ae?oyi ioe?ithaaee ca iieacieeii ?NAe,
(I. A. Eaon, 1988).

A?a??i?/iee noai ?ioiai? ii?iaeieie aecia/aee ca iaoiaeeeith TH. A.
Oaaei?iaa — A. A. Aieiaee?ii? (1971)

Aeey aecia/aiiy oaeoi??a ?eceeo, ye? iaoiiaeththoue ?icaeoie
ea???niaaiii? neooaoe??, iaie aeine?aeaeaii ie?ai? iieacieee ci?oaii?
neeie, ui oa?aeoa?ecothoue ?? i?ia?ae?coth/o caeaoi?noue. Caa?? ci?oaii?
neeie aeey aeine?aeaeaiiy i?iaiaeeany aac noeioeyoe?? /a?ac aea? aiaeeie
i?ney i?eeiio ?ae? oa iieineaiiy ?ioiai? ii?iaeieie aeenoeeueiaaiith
aiaeith, c aeia ii?iaeieie ?ioa ca aeiiiiiaith noa?eeueii? i?iaoee. O
i?e aecia/aee iniaeeaino? i?e?ie?enoae?caoe?? (IEN), (I. A. Eaon, 1977;
?. I. Aee/ei, ?. A. Oieeaanueea, 1988; E. A. Aeoa?ia?ia, 1988),
i?ia?ae?coth/ee iioaioe?ae (IIN), (O.I.Naeooe?ia, A. ?.Iicae??a, A. A.
Aoi/aa, 1992 ), a oaeiae eiioeaio?aoe?th eaeueoe?th (TH. O. Iaaeaiia,
1992). Aecia/aiiy ?I neeie i?iaiaeeeinue no??/eith ?iaeeeaoi?iiai iaia?o
0-12 (ae?iaieoeoaa *NN?). A’yce?noue neeie aei??thaaee a?ceiceiao?ii.
Iniaeeaino? IEN oa IIN aeine?aeaeaii o 307 ae?oae aei i?io?eaeoeee oa o
90 ae?oae i?ney ?? i?iaaaeaiiy. Aecia/aiiy ai?noo eaeueoe?th o ci?oai?e
neei? i?iaiaeeeinue o 120 ae?oae. Aiaeiaaee iieaciee aea/aii o 406
ae?oae oa o 193 aecia/aii a’yce?noue ci?oaii? neeie.

Aeine?aeaeaiiy ?ioiieia?/ieo aeanoeainoae ci?oaii? neeie ??oiooaaeinue
ia aea/aii? eiioeaio?aoe?? SIgA, IgA, IgG, IgM iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? a a?a?iaiio aae? (ca M. Mancini, 1965). Aecia/aiiy ai?noo
iniiaieo eean?a ?ioii?eiaoe?i?a i?iaaaeaii o 280 i?iaao ci?oaii? neeie.

Aeine?aeaeaiiiy ieoii? aiaee oa ??oioo c n??eiiinii? aaii?ia?ioe??
aeeiioaaeenue o eaai?aoi??? Euea?anueei? aaieiai?ica?aeoaaeueii?
aeniaaeeoe?? AeAI ’’Cao?aeoe?aaieia?y’’ (’’Aiaea ieoueaaay. Iaoiaeu
aiaeeca Ainnoaiaea?o NNN?, 1984; Io?aia i?e?iaeu. Ii/au., Aineii. NNN?
ii noaiaea?oai, 1987; Naieoa?iua i?aaeea e ii?iu io?aiu iiaa?oiinoiuo
aiae, 1998).

A?aea?? c?ace?a ? aiae?c ?ineeiii? i?iaeoeoe?? ia ai?no aaeiaeo oi?i
aaaeeeo iaoae?a i?iaiaeeany o eaai?aoi??? o?i?? oa a?io?i?? ??oioo
?inoeoooo aeieia?? Ea?iao IAI Oe?a?ie (Iaaeeeiaeieiae/aneea o?aaiaaiey e
naieoa?iua ii?iu ea/anoaa i?iaeiaieuenoaaiiiai nu?uey e ieuaauo
i?iaeoeoia IIC NNN?, 1990). Iino?eia eiinoeueoaoeaia ?iaioa
i?iaiaeeeanue aeieoi?ii aaia?ao?/ieo iaoe oa aeieoi?ii
aaieiai-i?ia?aeia?/ieo iaoe, i?ioani?ii ?oaeueei A. ?.

Ee?i?/i? niinoa?aaeaiiy ii i?io?eaeoeoe? ea???no coa?a i?iaiaeeee o
ae?oae 3-o, 6-oe, 9-oe oa 12-oe ??/iiai a?eo, ye? i?iaeeaathoue o
?a??ii? n??/aiiai ae?iaieoeoaa. Iniiaio a?oio neeaee 120 ae?oae, ye?
ia?aeaeueii c naiaoe??th ?ioiai? ii?iaeieie oa a?a??i?/iei aeoiaaiiyi,
i?eeiaee i?ioeea??ici? caniae. O eiio?ieueio a?oio oa?eoei oaeiae 120
ae?oae, yeei e??i naiaoe?? ii?iaeieie ?ioa oa iaa/aiiy iaae/eai a?a??ie,
niaoe?aeueii? i?io?eaeoeee ea???no ia i?iaiaeeeinue. C iaoith aecia/aiiy
aoaeoeaiino? i?io?eaeoe/ieo caoiae?a a?aoiaoaaee i?e??no ea??icieo coa?a
? ii?iaeiei, ci?ie i?ia?ae?coth/i? caeaoiino? oa ?ioiiiai oiio ci?oaii?
neeie, a oaeiae e?euee?noue ia?aianaieo noiooi?o caoai?thaaiue ca
ia??iae niinoa?aaeaiiy a na?aaeiueiio ia iaeio aeeoeio.

Aa??aoe?eii-noaoenoe/io ia?iaeo ee?i?/ieo ? eaai?aoi?ieo aeine?aeaeaiue
cae?enithaaee ca aeiiiiiaith iaeao?a i?eeeaaeieo i?ia?ai aeey
noaoenoe/iiai aiae?co aeaieo iaaeeei-a?ieia?/ieo aeine?aeaeaiue
’’Statgraphics’’ (Manugistics, Inc., 1992) oa ’’Instat’’(Graph Pad
Software Inc., 1993). Aeinoia??i?noue io?eiaieo ?acoeueoao?a
ioe?ithaaee, ??oiooth/enue ia ?ic?aooieao e?eoa??th Nouethaeaioa,
aecia/aii? caeiiii??iinoae ei?aeyoe?? aeaieo (I. ?. Niiey?, ss. I.
Oaaei??a oa ni?aaao., 1995).

?acoeueoaoe aeine?aeaeaiue

Ioe?ithth/e caaaeueio aaio?i?/io oa?aeoa?enoeeo ?a??iio aeine?aeaeaiue,
anoaiiaeaii ia?aaeuaiy ai?noo aaaeeeo iaoae?a ?, ?? oa ??? eeano
iaaacia/iino? o ??oioao, ia eeoa ia ??ai? na?aaei?o cia/aiue, aea e
aaee/ei AAeE. Iaea?eueo nooo?aei ? ia?aaeuaiiy AAeE aeey Pb (4-e?aoia),
? (3-e?aoia), Cr (3-e?aoia), Ba (3-e?aoia). Aaaeeeaei /eiieeii
aeiae?eey, yeee ia? aaciina?aaei?e aieea ia oi?ioaaiiy noiiaoieia?/iiai
caei?ia’y o ae?oae, ? ieoia aiaea. Ca ?acoeueoaoaie ioe?iee
a?ae?io?i?/ieo ia?aiao??a o ?a??ii? n??/aiiai ae?iaieoeoaa,
niinoa??aa?oueny cia/ia ia?aaeuaiiy a i?e ??aiy Sr a?aeiinii AAeE (o 6-7
?ac?a). Ia?aeaeueii o ieoi?e aiae? aeyaeaii iaaecae/aeii iaeo
e?euee?noue F (0,08-0,30 ia/e) oa Br (0,02-0,12 ia/e), a a aeayeeo
i?iaao oe?eeiaeoo ?o a?aenooi?noue. E??i oiai o ieoi?e aiae? cian?i
a?aenooi?e ? (0 ia/e).

Aiae?coth/e c?acee ?ineeiieoeueei? i?iaeoeoe?? anoaiiaeaii ia?aaeuaiiy o
ei?aiaieiaeao ??aiy Zn (1,5-4 e?aoia), Pb (3-e?aoia), Cd (5-e?aoia)
noiniaii AAeE. Aiae?c ei?ia’y/iai iieiea ia ai?no aaaeeeo iaoae?a
na?ae/eoue i?i i?aeaeuaiee ??aaiue ?b (1,5 — e?aoia ia?aaeuaiiy AAeE) ?
i?i i?enooi?noue aenieiai ??aiy Sr (1,57 ia/ea), yeee aeey oeueiai
i?iaeoeoo ia ?a?eaiaioo?oueny. Ioaea, ci?ia aaio?i?/iiai oa
a?ae?io?i?/iiai noaoono ?a??iio, yea ? iane?aeeii oaoiiaaiaco,
aacoiiaii, ia? nooo?aee aieea ia oi?ioaaiiy noiiaoieia?/iiai caei?ia’y
aeeoy/iai ianaeaiiy o aeine?aeaeoaaiiio ?a??ii?.

?acoeueoaoe ee?i?/iiai ianoaaeaiiy ae?oae iieacaee, ui o?aaeai?noue
coa?a ea???nii o ae?oae, ye? i?iaeeaathoue o ?a??ii? n??/aiiai
ae?iaieoeoaa, oa o ae?oae eiio?ieueii? a?oie, nooo?ai a?aei?iia. Oae, o
ae?oae, ye? iaoeathoue o n??eiiini?e aaii?ia?ioe??, iioe?ai?noue ea???no
coa?a nyaa? 92,863,17 %, ui ia 21,53 % a?eueoa, i?ae o ae?oae
eiio?ieueii? a?oie (?<0,001). C a?eii /anoioa ea???no ca?eueoo?oueny, a iaea?eueo nooo?aith ? ??cieoey o ae?oae 9-oe ??/iiai a?eo. Na?aae ae?oae oe??? a?eiai? ??aaeaoe?? iniiaii? a?oie ia aeyaeaii aeiaeii? ?c caei?iaeie coaaie, a oie /an ye o ae?oae oeueiai ae a?eo eiio?ieueii? a?oie caoai?thaaiiy ae?aaiinoiaaii o 75,154,14 %. O ianoaaeaieo ae?oae iaie i?iaiae?ciaaii ie?aii /anoioo ea???no iiei/ieo ? iino?eieo coa?a. ?acoeueoaoe aeine?aeaeaiue na?ae/aoue, ui ?iciianthaeaeai?noue ea???no iiei/ieo coa?a o ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe?? aeinoia??ii aeua ? noaiiaeoue, a na?aaeiueiio, 93,754,71 %, a o ae?oae eiio?ieueii? a?oie - 69,65,03 %, (?<0,05), a e?euee?noue ea??icieo coa?a, yea i?eiaaea? ia iaeio aeeoeio (ei) neeaaea? a?aeiia?aeii: 5,670,17 oa 3,430,37, (?<0,001). Ne?ae caoaaaeeoe, ui aenieo o?aaeai?noue iiei/ieo coa?a ea??iciei i?ioeanii o ae?oae iniiaii? a?oie ae?aaiinoiaaii, aaea o 3-o ??/iiio a?oe? (?iciianthaeaeai?noue ea???no - 81,644,09 %, i?e ei=4,340,22). ??E iiei/ieo coa?a o ae?oae oeueiai ?a??iio oa?aeoa?eco?oueny ye aenieee ? noaiiaeoue 1,220,33. Oea aeicaiey? i?eionoeoe, ui aaio?i?/i? oiiae ?a??iio i?iaeeaaiiy, iathoue nooo?aee aieea ia i?ioeane oi?ioaaiiy oaa?aeeo oeaiei coaa, ?o no?oeoo?o, ua a aioaiaoaeueiiio ia??iae? iioiaaiaco. Io?eiai? aeai? na?ae/aoue, ui iino?ei? coae o ae?oae c aeieia?/ii iani?eyoeeaiai ?a??iio ?oeiothoueny ea???nii oaeiae ?ioaineai?oa, i?ae o ae?oae eiio?ieueii? a?oie. Oae, a na?aaeiueiio, ?iciianthaeaeai?noue ea???no o ae?oae iniiaii? a?oie noaiiaeoue 79,418,01 %, i?ioe 57,536,05 % - a eiio?ieuei?e a?oi?, (?<0,05). Ia?aeaeueii anoaiiaeaii, ui ?ioaineaia o?aaeaiiy coa?a ea??iciei i?ioeanii o ae?oae, ye? ia?iaeeeeny a n??eiiini?e aaii?ia?ioe?? a?aecia/a?oueny aaea a 6-oe ??/iiio a?oe?. Oae, o a?eueoi? iieiaeie (54,875,73 %) ae?oae oeueiai a?eo ea???nii c?oeiiaai? ia?o? iino?ei? iiey?e. Nooo?ao ??cieoeth iaie aeyaeaii ? i?e ii??aiyii? iieaciee?a ?ioaineaiino?: EIA o ae?oae, ui iaoeathoue o ?a??ii? n??/aiiai ae?iaieoeoaa, noaiiaeoue a na?aaeiueiio 4,180,09, i?ioe 2,620,34 - a eiio?ieuei?e a?oi?, (?<0,001) . C a?eii, a iaio a?oiao ae?oae ?ioaineai?noue ea???no ca?eueoo?oueny. Oae, o ae?oae aeine?aeaeoaaiiai ?aa?iio EIA c?inoa? c 2,050,07 o 6-oue ?ie?a aei 5,850,09 - o 12-oue ?ie?a. I?e /iio cia/ia ca?eueoaiiy ?iaeaeno EIA a?aeaoaa?oueny o a?eueo ?aiiueiio a?oe? (6-oue - 9-oue ?ie?a). ??E iino?eieo coa?a noaiiaeoue 0,840,10, ui ca?aeii e?eoa???a AIIC a?aeiia?aea? aenieiio ??aith oa iania?e ?iciianthaeaeaiino?. A?aoiaoth/e aenie? iniiai? iieacieee ea???no coa?a, ye iiei/ieo, oae ? iino?eieo, iaie ioe?iaii ye?noue iaaeaiiy noiiaoieia?/ii? aeiiiiiae aeioe?eueiyoai oa oeiey?ai oeueiai ?a?i?io, ca?aeii iieacieea ?NAe. C’yniaaii, ui ?NAe noaiiaeoue 11,48 % ? oa?aeoa?eco?oueny ye iaaeinoaoi?e. Iaie aeyaeaii ia?aaaaeii aino?ee ia?aa?a ea???no, ye iiei/ieo oae ? iino?eieo coa?a o ae?oae c ?a??iio aeiaoaaiiy n??ee. O o?aoeie c ieo ae?aaiinooaaeenue oneeaaeiai? oi?ie ea???no (34,811,13 %), oiae? ye o ae?oae eiio?ieueii? a?oie ioeuei?oe oa ia??iaeiioeoe cono??/aeenue o aea?/? ??aeoa (15,020,54 %, ?<0,001). Aiae?coth/e /anoioo o?aaeaiino? coa?a ea???nii o ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe?? , caeaaeii a?ae ?o a?oiiai? iaeaaeiino? c’yniaaii, ui a iiei/ieo coaao ea???n aeii?io? o 85 oa 75 coaao, a?aeiia?aeii o 89,61 % oa 86,23 %. Ae?oaa i?noea ca /anoioith o?aaeaiiy caeiathoue 55 oa 65 coae, ye? o?aaeothoueny c iaeeiaeiaith /anoioith (79,18 % aeiaaee?a). Na?aae iino?eieo coa?a iaea?eueo /anoi o?aaeothoueny 46 oa 36 ( a?aeiia?aeii o 91,83 % oa 87,75 % aeiaaee?a), a aeaui ??aeoa 16 oa 26 coae (a?aeiia?aeii 69,13 % oa 71,07 % ae?oae). O o?iioaeuei?e a?oi? coa?a ea???n aeii?io? a 11 (28,57 %) oa 21 (30,61 %) coaao. I?e aiae?c? aeoeaiino? ea??iciiai i?ioeano anoaiiaeaii, ui e?euee?noue ae?oae iniiaii? a?oie, ye? iathoue iiiaeeii? ea??ici? o?aaeaiiy (???-?e nooi?iue aeoeaiino? ea???no) nyaa? 47,982,82 %. Iaoii?noue o ae?oae eiio?ieueii? a?oie ia?aaaaea? ??-ee nooi?iue aeoeaiino? ea???no (35,123,05 %). A?aeiii, ui i?ia?aeia cia/aiiy o neeaaeiiio iaoai?ci? ?icaeoeo ea???no coa?a iaeaaeeoue a?a??i? ?ioiai? ii?iaeieie, ?? yeino? oa ?a?oey?iino?. O ca’yceo c oeei, iaie i?iaaaeaii aiae?c yeino? aeiaeyaeo ca ?ioiaith ii?iaeieiith o ae?oae c n??eiaeaeiaoaiiai ?a??iio. Io?eiai? ?acoeueoaoe na?ae/aoue, ui caaaeii c /enea iieoaieo, uiaeaiii /enoyoue coae 56,143,11 %, aea eeoa 31,421,15 % c ieo ?iaeyoue oea aea?/? ia aeaiue, 37,611,18 % ae?oae /enoyoue coae o?eueee a?aioe? oa e oi aei ni?aeaieo, 16,661,75 % oeiey??a - ia??iaee/ii, a 14,281,83 % - ia /enoyoue acaaae?. I?ioa aeai? ee?i?/iiai ianoaaeaiiy ae?oae, a?aeia?aaeathoue a?eueo ia’?eoeaio ea?oeio nooiaiy i/euaiiy coa?a, yea ia?icae?eueii iia’ycaia c aeiaeyaeii ca ?ioiaith ii?iaeieiith. Aeia?a a?a??ia ii?iaeieie ?ioa (ca?aeii ?iaeaeno Oaaei?iaa-Aieiaee?ii?) aeaeaia eeoa o 10,961,8 % ianoaaeaieo ae?oae, iacaaeia?eueia - o 40,342,81 %, iiaaia ? aeoaea iiaaia o 29,501,60 % ae?oae. I?e aiae?c? iaoiaeeee /euaiiy coa?a iaie c’yniaaii, ui 42,242,37 % iieoaieo ae?oae ia i?aaeeueii /enoyoue coae. Aiae?coth/e ca’ycie i?ae a?a??i?/iei noaiii ?ioiai? ii?iaeieie oa ?ioaineai?noth o?aaeaiiy coa?a ea???nii, anoaiiaeaii, ui o ae?oae ??cieo a?eiaeo a?oi i?e ?a?oey?iiio aeiaeyae? ca ?ioiaith ii?iaeieiith aeii?io? ?-ee nooi?iue aeoeaiino? ea???no, a i?e ia?a?oey?iiio aai a?aenooiueiio - cia/ii /ano?oa cono??/a?oueny ??-ee oa ???-?e nooiai? aeoeaiino? ea???no. Ne?ae a?aecia/eoe, ui na?aae i?noeaaeo oaeoi??a, ye? iaoiiaeththoue aeieeiaiiy ea???no oa aeoeaiee eiai ia?aa?a, i?ia?aeia i?noea iaeaaeeoue ci?oai?e neei?, ?? i?ia?ae?coth/ee caeaoiino?, neeaaeo oa aeanoeainoyi, ye? caeaoi? ci?ithaaoenue i?ae aieeaii ??ciiiai?oieo /eiiee?a. Oiio, caeiiii??ieie aeyaeeinue aeine?aeaeaiiy ie?aieo ?? iieaciee?a o ae?oae c aeieia?/ii iani?eyoeeaiai ?a??iio. Aiae?c a?io?i?/ieo ? ii?oieia?/ieo iieaciee?a ci?oaii? neeie i?iaiaeeee caeaaeii a?ae i?noey i?iaeeaaiiy ae?oae, ?o a?eo, a oaeiae nooiaiy aeoeaiino? ea??iciiai i?ioeano. C’yniaaii, ui aiaeiaaee iieaciee ci?oaii? neeie (?I) o ??ci? a?eia? ia??iaee ae?oae iniiaii? a?oie eieeaa?oueny a?ae 6,380,05 aei 6,640,07, a a eiio?ieuei?e a?oi? oeae iieaciee ci?ith?oueny a iaaeao a?ae 6,710,06 aei 6,840,04. O na?aaeiueiio, ?aaeoe?y ci?oaii? neeie o ae?oae, ?c caa?oaeiaiiai ?a??iio ? neaaieeneith (6,510,07). O ae?oae, ui i?iaeeaathoue iiaeeco n??eiaeaeiaoaiiai eiiieaeno i?e ?-io nooiai? aeoeaiino? ea???no ?aaeoe?y ci?oaii? neeie ? iaaeeaeaiith aei iaeo?aeueii? (?I=6,650,09). ?c c?inoaiiyi ?ioaineaiino? ea???no, ?I ci?oaii? neeie cieaeo?oueny aei 6,560,09 ? ?aaeoe?y neeie ci?ith?oueny a a?eueo eeneo noi?iio. I?e iiiaeeiieo ea??icieo o?aaeaiiyo ?aaeoe?y neeie ? iaeneiaeueii iaaeeaeaiith aei eenei?, a cia/aiiy ?I=6,330,07 ? e?eoe/iei aeey ?icaeoeo ea??iciiai i?ioeano. A’yce?noue ci?oaii? neeie o ianoaaeaieo ae?oae oaeiae, o iaai?e i???, caeaaeeoue a?ae a?eo oa a?ae nooiaiy o?aaeaiino? coa?a ea???nii. Oae, yeui o ae?oae 3-o ??/iiai a?eo, ui i?iaeeaathoue o aeine?aeaeoaaiiio ?a??ii?, a’yce?noue ci?oaii? neeie ? iaeieae/ith e noaiiaeoue 2,380,12, oi c a?eii ?? cia/aiiy ca?eueoothoueny aei 3,080,02 - o ae?oae 12-oe ??/iiai a?eo. Aiaeia?/i? caeiiii??iino? niinoa??aathoueny e o ci?oai?e neei? ae?oae eiio?ieueii? a?oie (a?aeiia?aeii ?? cia/aiiy ci?ith?oueny c 1,610,02 aei 2,190,06, ?<0,001). Ia?aeaeueii, iaie c’yniaaii, ui o an?o a?eiaeo ??aaeaoe?yo ye iniiaii? oae ? eiio?ieueii? a?oi, ?icaeoie ea??iciiai i?ioeano noi?iaiaeaeo?oueny c?inoaiiyi a’yceino? ci?oaii? neeie. A o ae?oae c iiiaeeiieie ea??icieie o?aaeaiiyie eiinoaoiaaii iaeaeu? iieacieee a’yceino? ci?oaii? neeie, a iniiai?e a?oi? 2,930,08, oa a eiio?ieuei?e - 2,000,03, (?<0,001). Iaie aoei anoaiiaeaii, ui ai?no eaeueoe?th o ci?oai?e neei? ianoaaeaieo ae?oae caeaaeeoue a?ae ?a??iio i?iaeeaaiiy oa a aeaye?e i??? a?ae ?o a?eo. Noiniaii na?aaei?o iieaciee?a ai?noo eaeueoe?th o ci?oai?e neei? ae?oae iniiaii? a?oie, oi aiie, a?eueo, i?ae o aea?/? ? aeueie, i?ae o eiio?ieuei?e (a?aeiia?aeii 2,030,04 iiieue/e oa 0,960,05 iiieue/e, ?<0,001). Oaeo caeiiii??i?noue aeyaeaii a on?o aac aeiyoeo a?eiaeo ??aaeaoe?yo. O ??ci? a?eia? ia??iaee o ae?oae iniiaii? a?oie ??aaiue eaeueoe?th o ci?oai?e neei? eieeaa?oueny a iaaeao a?ae 0,970,03 iiieue/e aei 2,080,03, (?<0,01). Iaoii?noue, eiai eiioeaio?aoe?y o eiio?ieuei?e a?oi? c a?eii iaeaea ia ci?ith?oueny, (?>0,05).

Ia?aeaeueii iaie c’yniaaii, ui nooi?iue aeoeaiino? ea???no o ae?oae
iniiaii? a?oie caeaaeeoue a?ae ai?noo eaeueoe?th o ci?oai?e neei?.
Iiiaeeiiee ea???n noi?iaiaeaeo?oueny i?aeaeuaiiyi ??aiy eaeueoe?th a
ci?oai?e neei? oa iaeaeuith eiai eiioeaio?aoe?y ? i?e ???-io nooiai?
aeoeaiino? ea???no — 2,200,03 iiieue/e. ??cieoey ? noaoenoe/ii
aeinoia??iith, ?<0,05. E??i oiai, anoaiiaeaii i?yiee ei?aeyoe?eiee ca’ycie i?ae ai?noii eaeueoe?th o ci?oai?e neei? oa ?? a’yce?noth i?e ??ci?e ?ioaineaiino? ea???no (r=0,140,11; ?<0,001). ? iaaiaee, i?ae eiioeaio?aoe??th eaeueoe?th oa aiaeiaaei iieacieeii ?nio? iaa?iaiee ei?aeyoe?eiee ca’ycie (r=-0,160,01; ?<0,001). Ca?eueoaiiy eiioeaio?aoe?? eaeueoe?th a ci?oai?e neei?, ia iaoo aeoieo, ? iiaeeeaei, ii-ia?oa ca ?aooiie ii?ooaiiy eiai ca’ycoaaiiy a i?ioean? i?ia?ae?caoe?? aiae?, oa ii-ae?oaa, i?e ?I neeie ieae/iio a?ae 7,0 iiaeeeaee iineeaiee aeo?ae eaeueoe?th c aiae? a neeio . O ?acoeueoao? aea/aiiy oaiiiaio i?e?ie?enoae?caoe?? ci?oaii? neeie, ui oa?aeoa?eco? ?? i?ia?ae?coth/ee iioaioe?ae anoaiiaeaii, ui o 45,20 2,16% ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe??, ia?aaaaeathoue e?enoaee III oeio, ui cia/ii /ano?oa, i?ae o ae?oae eiio?ieueii? a?oie (25,633,76 %, ?<0,01). E?enoaee I oeio o ci?oai?e neei? cono??/athoueny eeoa o 13,473,54% in?a, a oie /an, ye o ae?oae eiio?ieueii? a?oie ?o /anoioa ? aeuith ? noaiiaeoue 27,663,19, (P<0,001). ?? oei i?e?ie?enoae?caoe?? iaeaea c iaeeiaeiaith /anoioith cono??/a?oueny o ci?oai?e neei? ae?oae iaio aeine?aeaeoaaieo a?oi (a?aeiia?aeii : o 41,333,75 % ? o 46,672,02 % ae?oae, ?>0,2).

Aiae?c a?eiaeo iniaeeainoae ?iciiae?eo oei?a e?enoae?a o ci?oai?e neei?
na?ae/aoue, ui iaeni?eyoeea?oa ?o ni?aa?aeiioaiiy aeyaeaii o ae?oae 3-o
??/iiai a?eo iaeaeaio aeine?aeaeoaaieo a?oi. ? oei IEN cono??/a?oueny o
15,782,12 % ae?oae iniiaii? a?oie oa o o?aoeie ae?oae (32,452,94 %)
eiio?ieueii? a?oie, (?<0,01). O ae?oae 6-oe ??/iiai a?eo niinoa??aa?oueny cieaeaiiy ieoiii? aaae e?enoae?a ? oeio, ca ?aooiie nooo?aiai ca?eueoaiiy e?enoae?a ?? oeio o ci?oai?e neei? aei 51,563,17 % - a iniiai?e a?oi? (?<0,05) oa aei 33,332,82 % o eiio?ieuei?e, (?<0,01). I?ioa, yeui o 12-oe ??/ieo ae?oae iniiaii? a?oie ia?aaaaeathoue o ci?oai?e neei? e?enoaee ??? oeio (45,452,90 %) , oi o a?eueoi? iieiaeie ae?oae eiio?ieueii? a?oie ci?oaia neeia oa?aeoa?eco?oueny ?? oeiii IEN (51,262,86%). Aea ia i?e?ii?aia?aoao cono??/aeenue aeiaaeee, ye? iiaeia ioa?aeoa?ecoaaoe iaeii/anii, ye ? oa ??, aai ?? oa ??? oeie IEN. Oea, cae/aeii, cao?oaeithaaei ioe?ieo oa io?eiaiiy oi/ieo ?acoeueoao?a. Oiio aea/aiiy IIN i?iaiaeeeinue o aaeao, c o?aooaaiiyi on?o iniaeeainoae IEN. Anoaiiaeaii, ui o ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe?? IIN ? iecueeei, ? a na?aaeiueiio, noaiiaeoue 1,500,11 aaee. Iaoii?noue, o ae?oae eiio?ieueii? a?oie IIN oa?aeoa?eco?oueny ye caaeia?eueiee - 2,380,32 aaee (P<0,001). Oey caeiiii??i?noue i?ine?aeeiao?oueny a on?o a?eiaeo ??aaeaoe?yo. ?icaeoie ea??iciiai i?ioeano o ae?oae c aeieia?/ii iani?eyoeeaiai ?a??iio noi?iaiaeaeo?oueny nooo?aei cieaeaiiyi IIN c 2,380,11 aaee (?-ee nooi?iue aeoeaiino? ea???no) aei 0,950,17 aaee (???-?e nooi?iue aeoeaiino? ea???no ), ?<0,001. I?e iiiaeeiieo ea??icieo o?aaeaiiyo IIN oa?aeoa?eco?oueny ye aeoaea iecueeee. A?aoiaoth/e, ui oe?aeeea? /eiieee aeiae?eey iae/ano?oa aieeaathoue ia ?ioiio nenoaio, iaie aeine?aeaeaii ?ioiieia?/iee noaoon ?ioiai? ii?iaeieie a ianoaaeaieo ae?oae. Aiae?coth/e ??aaiue SIgA o ci?oai?e neei? ae?oae c aeieia?/ii iani?eyoeeaiai ?a??iio, anoaiiaeaii, ui a na?aaeiueiio, eiai eiioeaio?aoe?y noaiiaeoue 0,7660,06 a/e i?ioe 1,2830,053 a/e - o eiio?ieuei?e a?oi?, (?<0,001). C a?eii ai?no SIgA o ci?oai?e neei? ae?oae ye iniiaii? oae ? eiio?ieueii? a?oi c?inoa?, a iaeaeueie eiai iieacieee ? o 9-oe ??/ieo ae?oae, a?aeiia?aeii 1,0550,038 a/e oa 1,6590,032 a/e (?<0,001). Na?aaei? iieacieee ai?noo IgA o ci?oai?e neei? ae?oae, ui i?iaeeaathoue iiaeeco n??/aiiai ae?iaieoeoaa, ? a aea?/? aeueie, i?ae aiaeia?/i? o eiio?ieuei?e a?oi? (a?aeiia?aeii: 0,4540,034 a/e oa 0,2050,017 a/e, ?<0,001). Noiniaii ai?noo IgM o ci?oai?e neei?, anoaiiaeaii, ui eiai eiioeaio?aoe?y ? aeuith o ia?aaaaei?e a?eueoino? a?eiaeo ??aaeaoe?e iniiaii? a?oie ii a?aeiioaiith aei eiio?ieueii?. Aeiyoie noaiiaeyoue eeoa ae?oe 3-o ??/iiai a?eo o yeeo ai?no IgM o ci?oai?e neei? ? cia/ii ieae/ei - 0,1750,018 a/e, i?ae o ae?oae eiio?ieueii? a?oie - 0,3010,015 a/e, (?<0,001). Iaie anoaiiaeaii, ui ??aaiue aeine?aeaeoaaieo a?oi ?ioii?eiaoe?i?a o ci?oai?e neei? nooo?ai aieeaa? ia ?icaeoie ea???no coa?a o ianoaaeaieo ae?oae. Cieaeaiiy ?o eiioeaio?aoe?? i?ecaiaeeoue aei c?inoaiiy nooiaiy aeoeaiino? ea???no. Ioaea, ?acoeueoaoe iaoeo aeine?aeaeaiue na?ae/aoue, ui o ae?oae, ye? i?iaeeaathoue o ?a??ii? aeiaoaaiiy n??ee, a?aei?/athoueny aenie? iieacieee o?aaeaiino? coa?a ea???nii. Ee?i?/i? niinoa?aaeaiiy ca ia?aa?aii ea??iciiai i?ioeano, aea/aiiy i?ia?ae?coth/i? caeaoiino? oa ?ioiiiai oiio ci?oaii? neeie noaee aaaiieie i?e/eiaie aeey ?ic?iaee eiiieaeno aoaeoeaieo i?io?eaeoe/ieo caoiae?a, aaeaioiaaieo aeey aeaiiai eiioei?aioo ae?oae. O ca’yceo c oeei, ianooiiei aoaiii iaoeo aeine?aeaeaiue aoei aea/aiiy aoaeoeaiino? aieeao cai?iiiiiaaiiai i?io?eaeoe/iiai eiiieaeno ia oaa?ae? oeaieie coa?a ? ea???niaaiio neooaoe?th ?ioiai? ii?iaeieie o ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe??. A?aoiaoth/e ?acoeueoaoe yeino? aeiaeyaeo ca coaaie, ia?aae i?iaaaeaiiyi naiaoe?? ii?iaeieie ?ioa ae?oe ?aoaeueii iaa/aeenue i?aaeeueiiio /euaiith coa?a, aeei?enoaiith ??cieo cania?a a?a??ie. I?ney oeueiai i?iaiaeeeanue iaaeeeaiaioicia i?io?eaeoeea, yea aeeth/aea: aaeeaaiiy ’’A?io?eoo-N’’ oa ae?oea?ioinoaoo eaeueoe?th (a?aeiia?aeii aeiaiaei aeicai aeey ae?oae ??ciiai a?eo). C iaoith iiia?aaeaeaiy oi?ioaaiiy coaiiai iaeueioo, iie?auaiiy i?ia?ae?coth/i? caeaoiino? ci?oaii? neeie oa i?aeaeuaiiy oaeoi??a caoenoo ?ioiai? ii?iaeieie, canoiniaoaaee iieineaiiy coaiei ae?ene?ii ’’A?iaeaio-2’’ (o?e/? ia aeaiue i?ney ?ae?) oa ?ioia? aaiii/ee c 0,2 % ?ic/eiii ooi?eaeo iao??th (iaeei ?ac ia i?nyoeue i?ioyaii ?ieo). Cai?iiiiiaaiee iaie eiiieaen i?iaiaeeany ae?oyi i?ioyaii i?nyoey. I?e ?-io nooiai? aeoeaiino? ea???no - iaeei ?ac ia ??e, i?e ??-io oa ???-io nooiaiyo - aea?/? ia ??e. E??i oiai ’’A?io?eo-N’’ ae?oyi c ???-?i nooiaiai aeoeaiino? ea???no i?ecia/aee o?e/? ia ??e. Aeey aea/aiiy aoaeoeaiino? cai?iiiiiaaiiai i?io?eaeoe/iiai eiiieaeno aoei acyoi i?ae niinoa?aaeaiiy 120 ae?oae, a yeeo aeine?aeaeaii i?e??no ?ioaineaiino? ea???no ca iieacieeaie : eic, eii, EIAc oa EIAi, ci?ie i?ia?ae?coth/i? caeaoiino? ci?oaii? neeie, a oaeiae ??aaiue ?ioii?eiaoe?i?a ?ioiai? ii?iaeieie. Na?aae ae?oae, yeei i?iaiaeeeenue i?io?eaeoe/i? caoiaee, ca ia??iae niinoa?aaeaiiy 2,5 ?iee, e?euee?noue ea??icieo iiei/ieo coa?a, a na?aaeiueiio neeaea eic=6,100,42, a ea??icieo ii?iaeiei eii=7,150,40, ui iaioa, i?ae o eiio?ieuei?e a?oi? (a?aeiia?aeii: eic=7,760,50 oa eii=9,520,66 , ?1<0,05 oa ?2<0,001). Nooo?aa ??cieoey a i?e?ino? ea??icieo iiei/ieo coa?a ? ii?iaeiei oa?aeoa?ia aeey an?o a?eiaeo ??aaeaoe?e. I?e??no ea??icieo iiei/ieo coa?a o ae?oae, ye? i?eeiaee i?ioeea??iciee eiiieaen, cia/ii ieae/ee ( eic= 0,920,40) , i?ae o ae?oae eiio?ieueii? a?oie, ( eic=2,450,45). ?aaeoeoe?y ea???no iiei/ieo coa?a o ae?oae c n??eiiinii? aaii?ia?ioe?? neeaea 62,44%. Ia?aeaeueii i?iaaaeaii e aiae?c aieeao i?io?eaeoe/iiai eiiieaeno ia ?acenoaioi?noue iino?eieo coa?a aei ea???no. O ?acoeueoao? aeine?aeaeaiiy anoaiiaeaii, ui e?euee?noue ea??icieo iino?eieo coa?a o ae?oae, yeei ii?yae ?c naiaoe??th ?ioiai? ii?iaeieie, i?iaiaeeeenue ? i?io?eaeoe/i? caoiaee, ? cia/ii iaioith, o ii??aiyii? c ae?oueie, yeei i?iaiaeeeanue eeoa naiaoe?y. Oae, yeui o ae?oae iniiaii? a?oie EIAc=5,560,29, oi a eiio?ieuei?e a?oi? - EIAc=6,980,43 , (?<0,01). Nooo?ao ??cieoeth anoaiiaeaii ? a e?eueeino? ea??icieo ii?iaeiei. O na?aaeiueiio, a ae?oae iniiaii? a?oie EIAi=6,510,41, ui ieae/a, i?ae a eiio?ieuei?e, aea EIAi=8,340,55 , (?<0,05). Aiaeia?/io caeiiii??i?noue anoaiiaeaii a on?o a?eiaeo a?oiao. I?e??no ?ioaineaiino? ea???no iino?eieo coa?a ca 2,5 ?iee o ae?oae iniiaii? a?oie neeaa 1,470,15 coaa, a o ae?oae eiio?ieueii? - 2,930,31. ?ica?aei?noue o i?e?ino? ?ioaineaiino? ? noaoenoe/ii aeinoia??iith, ?<0,001. ?aaeoeoe?y ea???no iino?eieo coa?a o ae?oae iniiaii? a?oie neeaea - 49,82 %. O i?ioean? i?iaaaeaiiy i?io?eaeoe/ieo caoiae?a iaie aoei aecia/aii ai?no ?ioii?eiaoe?i?a o ci?oai?e neei?. Ia 6-ee aeaiue i?ney caaa?oaiiy i?ny/iiai eo?no i?io?eaeoeee, o ae?oae 6-oe oa 12-oe ??/iiai a?eo aeine?aeaeaii ??aaiue SIgA, IgA, IgG oa IgM. Io?eiai? aeai? na?ae/aoue i?i nooo?aa i?aeaeuaiiy ai?noo an?o a?oi ?ioii?eiaoe?i?a. Iaea?eueo ae?aaeaiei aeyaeeinue c?inoaiiy ai?noo S?gA oa IgA o ci?oai?e neei?. Eiioeaio?aoe?y aeuacaaaeaieo ?ioii?eiaoe?i?a ca?eueoeeanue o 1,5 ?ace, a?aeiia?aeii: c 0,7870,025 a/e aei 1,1160,032 a/e oa c 0,4290,027 aei 0,6280,032 a/e. Oe? ca?eueoaiiy ? noaoenoe/ii aeinoia??ieie, (?<0,05). Nooo?aei aeyaeeinue ? c?inoaiiy ??aiy IgG oa IgM o ci?oai?e neei? ae?oae, ui i?iaeeaathoue o n??eiiini?e aaii?ia?ioe??, i?ney i?iaaaeaiiai i?io?eaeoe/iiai eo?no, (?<0,05). Ia?aeaeueii iaie anoaiiaeaii, ui ?ic?iaeaiee i?ioeea??iciee eiiieaen, ni?ey? ii?iae?caoe?? i?ia?ae?coth/i? ooieoe?? ci?oaii? neeie. Oea i?aeoaa?aeaeo?oueny e ?acoeueoaoaie aeine?aeaeaiiy i?e?ie?enoae?caoe?? oa i?ia?ae?coth/iai iioaioe?aeo ci?oaii? neeie o ae?oae, yeei i?iaiaeeeenue cai?iiiiiaai? i?io?eaeoe/i? caoiaee. Aeyaeaii, ui i?ney i?ny/iiai eo?no i?io?eaeoeee, cia/ii ci?iththoueny oeie IEN. sseui aei ii/aoeo i?iaaaeaiiy i?io?eaeoe/ieo caoiae?a o ae?oae, ui i?iaeeaathoue iiaeeco n??eiaeaeiaoaiiai eiiieaeno ia?aaaaeaa ??? oei IEN (48,503,09 %), oi i?ney ?o i?iaaaeaiiy ieoiia aaaa e?enoae?a oeueiai oeio o ci?oai?e neei? nooo?ai cieceeanue aei 23,02,17 %, (?<0,001). Iaoii?noue aeinoia??ii ca?eueoeeanue /anoioa e?enoae?a ?? oeio c 39,204,81 % aei 60,001,84 %, (?<0,001). Cia/ii i?aeaeuo?oueny ? IIN i?ney i?iaaaeaiiy i?io?eaeoeee o ae?oae aeine?aeaeoaaii? a?oie. Oae, yeui aei ii/aoeo i?iaaaeaiiy i?ioeea??icieo caoiae?a IIN aoa 1,440,44 aaee ? oa?aeoa?ecoaaany ye iecueeee, oi i?ney ?o i?iaaaeaiiy a?i noa? caaeia?eueiei (2,380,14 aaee), (?<0,05). Ioaea, io?eiai? ca 2,5 ?iee niinoa?aaeaiue ?acoeueoaoe na?ae/aoue i?i aeineoue aenieo ea???nnoaoe/io ae?th ai?iaaaeaeaiiai iaie i?io?eaeoe/iiai eiiieaeno. ?aeiiaiaeiaaia noaia i?io?eaeoeee ea???no coa?a o ae?oae, ui i?aeaeathoueny cia/iei aio?iiiaaiiei iaaaioaaeaiiyi, i?inoa oa aeinooiia aeey aeeiiaiiy o e?eoaaeueieo caeeaaeao. Aeai? ee?i?/ieo ? eaai?aoi?ieo aeine?aeaeaiue aeathoue iiaeeea?noue aaaaeaoe, ui a eiiieaen i?io?eaeoe/ieo caoiae?a ae?oyi, ui i?iaeeaathoue a aeieia?/ii iani?eyoeeaeo ?a??iiao, ia?aeaeueii c i?aia?aoaie eaeueoe?th oa ooi?o a ii?aeiaii? c iaa/aiiyi iaae/eai a?a??ie ii?iaeieie ?ioa, iiaeii? aeeth/aoenue a?iaaii? noeioeyoi?e, ye? noaa?e?cothoue ye caoeni? nenoaie aeeoy/iai i?aai?cio a oe?eiio, oae ? i?noeaa? caoeni? iaoai?cie ?ioiai? ii?iaeieie cie?aia. AENIIAEE 1. Oaeoi?e iaaeieeoiueiai na?aaeiaeua, oi/a ? neeaaeathoueny c ie?aieo eiiiiiaio?a, ae?thoue ia aeeoy/ee i?aai?ci ye ?aeeia oe?ea ? i?ecaiaeyoue aei cieaeaiiy eiai aaeaioaoe?eii-caoenieo iiaeeeainoae . Aieea aio?iiiaaiieo oaeoi??a cia/iith i??ith a?aeia?aaea?oueny ? ia iioiaaiac?, ni?ey? oi?ioaaiith iaoieia?/ii? neooaoe?? a ?ioia?e ii?iaeiei?, ui i?iyaey?oueny iiiaeeiieie ea??icieie o?aaeaiiyie, oi?ioaaiiyi iaiiaiioe?iii? no?oeoo?e aiae?, caoai?thaaiiyie oeaiei ia?iaeiioa oa coai-uaeaiieie aiiiae?yie. 2. Aeyaeaia iaa?iiaaeaeaiiy o?i?/ieo aeaiaio?a ?, ?? oa ??? eeano iaaacia/iino? o ??oioao (Pb, Zn, Ba, Cr, P), ci?ia a?ae?io?i?/ii? oa?aeoa?enoeee ieoii? aiaee, a?aenooi?noue o i?e ooi?o, eiaeo oa a?iio, caa?oaeiaiiy ?ineeiieoeueei? i?iaeoeoe?? naeioeai oa eaaei??i, a oaeiae i?aeaeuaiee ??aaiue naeioeth oa i?enooi?noue co?iioe?th a iieioe?, ni?eythoue ?icaeoeo ea???no coa?a o ae?oae, ui i?iaeeaathoue o ?a??ii? aeiaoaaiiy n??ee oa iaoyaeothoue eiai ee?i?/iee ia?aa?a. 3. Anoaiiaeaii, ui na?aaei? iieacieee o?aaeaiino? coa?a ea???nii o ae?oae c ?a??iio aeiaoaaiiy n??ee, a?aeiia?aeathoue aenieiio ??aith ca?aeii e?eoa???a AIIC. ?iciianthaeaeai?noue ea???no iiei/ieo coa?a noaiiaeoue 93,754,71 %, iino?eieo - 79,018,01 % i?e ?ioaineaiino? a?aeiia?aeii: 5,670,17 oa 4,180,09 coaa. Iae/ano?oa cono??/a?oueny ???-?e nooi?iue aeoeaiino? ea???no - o 47,982,28 % aeiaaee?a. Aeoeai?noue ea???no ??-ai nooiaiy aeyaeaia o 26,872,13 % ianoaaeaieo ae?oae, a ?-ee nooi?iue - o 16,503,09 %. Ieoiia aaaa oneeaaeiaieo oi?i ea???no na?aae ae?oae aeine?aeaeoaaiiai ?a??iio noaiiaeoue 34,812,26 %. 4. O eiiieaen? ao?iiaoiaaiaoe/iiai aieeao ia aeieeiaiiy oa ia?aa?a ea???no coa?a iaaaeyea i?noea caeia? a?a??ia ii?iaeieie ?ioa. C /enea iieoaieo ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe?? , uiaeaiii /enoyoue coae 56,143,11 % , iaeiae a?eueo?noue c ieo (69,841,02 %) iathoue iacaaeia?eueiee, iiaaiee oa aeoaea iiaaiee aeiaeyae ca ?ioiaith ii?iaeieiith. Aeia?ee noai a?a??ie aeyaeaii eeoa o 10,981,18 % ae?oae. 5. O ae?oae, ye? i?iaeeaathoue a aeieia?/ii caa?oaeiaiiio ?a??ii?, aiaeiaaee iieaciee ci?oaii? neeie ? nooo?ai ieae/ei, i?ae o eiio?ieuei?e a?oi?, a eiai cia/aiiy iaeneiaeueii cnoioo? a eeneo noi?iio. Anoaiiaeaii ? aenie? iieacieee a’yceino?, a oaeiae i?aeaeuaiee ai?no eaeueoe?th o ci?oai?e neei? ae?oae aeine?aeaeoaaiiai ?a??iio ii??aiyii c eiio?ieueiith a?oiith. Aeyaeaii i?yiee ei?aeyoe?eiee ca’ycie i?ae ai?noii eaeueoe?th o ci?oai?e neei? oa a’yce?noth (r=0,140,11) oa iaa?iaiee ei?aeyoe?eiee ca’ycie i?ae eiai ai?noii ? ?I (r=-0,160,01). 6. Anoaiiaeaii, ui iaoiaeeea ioe?iee i?ia?ae?coth/iai iioaioe?aeo oa aecia/aiiy i?e?ie?enoae?caoe?? ci?oaii? neeie ia’?eoeaii oa?aeoa?ecothoue ia?aa?a ea??iciiai i?ioeano. I?ia?ae?coth/a caeaoi?noue ci?oaii? neeie o ae?oae aeine?aeaeoaaiiai ?a??iio cieaeaia, ia?aaaaea? ??? oei IEN (45,204,96 %) ? aiia oa?aeoa?eco?oueny iecueeei i?ia?ae?coth/ei iioaioe?aeii (1,500,11 aaee). 7. O ae?oae, ui i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa, niinoa??aathoueny ci?ie e?eueeino? ?ioii?eiaoe?i?a o ci?oai?e neei?. Ai?no SIgA ? ?noioii ieae/ei (0,7660,060 a/e), i?ae o ae?oae eiio?ieueii? a?oie (1,2830,053 a/e), a ?icaeoie ea??iciiai i?ioeano noi?iaiaeaeo?oueny a?eueo ae?aaeaiei cieaeaiiyi eiai eiioeaio?aoe??. Ea???n coa?a o ae?oae aeine?aeaeoaaiiai ?a??iio i?io?ea? ia oii? i?aeaeuaiiy ai?noo ?ioiiaeiaoe?i?a A, I oa aeayeiai cieaeaiiy IgG o ci?oai?e neei? ii??aiyii c ae?oueie eiio?ieueii? a?oie. 8. Cai?iiiiiaaiee eiiieaen i?io?eaeoe/ieo caoiae?a, yeee aeeth/a? eiia?iiaaia canoinoaaiiy a?iaaiieo noeioeyoi??a, a oaeiae i?aia?ao?a eaeueoe?th, ooi?o o ii?aeiaii? c a?aeiia?aeiith ae??oith oa iaa/aiiyi iaae/eai a?a??ie ?ioiai? ii?iaeieie, noaa?e?co? ea??iciee i?ioean, ni?ey? i?enei?aiith ii?iae?caoe?? i?ia?ae?coth/iai iioaioe?aeo ci?oaii? neeie, ?? ?ioiieia?/ieo iieaciee?a oa caaacia/o? ?aaeoeoe?th ea???no iiei/ieo coa?a 62,44 %, iino?eieo - 49,82 %. Nienie i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe?? 1. E?oiiee I. I. Iniaeeaino? i?e?ie?enoae?caoe?? ci?oaii? neeie o ae?oae ?a??iio n??/aiiai ae?iaieoeoaa // A?niee noiiaoieia??. - 1997. - ? 3 . - N. 454-457 2. E?oiiee I. I. Ea???n coa?a o ae?oae, ye? i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa // Iiaeie noiiaoieia??. - 1998. - ? 4. - N. 24-25 3. Niiey? I. ?., E?oiiee I. I. Aoaeoeai?noue canoinoaaiiy a?iaaiieo noeioeyoi??a aeey i?io?eaeoeee ea???no coa?a o ae?oae c aeieia?/ii iani?eyoeeaiai ?a??iio // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y oa a?io?i?y. - 1999. - ? . - N. 4. E?oiiee I. I., A??/ae A. A. A?a??i?/iee noai ii?iaeieie ?ioa o ae?oae oa i?aee?oe?a, ui i?iaeeaathoue a oiiaao ?ioaineaiiai aeiaoaaiiy n??ee // Noiiaoieia?/i? iiaeie. - Euea?a, 1995. - N. 53-54 5. E?oiiee I. I., A?a?e N. I., Aacaooei A. A., ?oaeueei A. ?., Oaaeina?a A. I. Nioe?aeueii-aeieia?/i? aniaeoe ea???no oa iaea??icieo o?aaeaiue oaa?aeeo oeaiei coa?a // Oai?aoe/i? oa i?eeeaaei? aniaeoe nioe?iaeieia??: Iaoa?. ?-i? Anaoe?a?inueei? eiioa?aioe?? . - Oii 2. - Euea?a, 1996. - N. 165-167 6. E?oiiee I. I. Aieea a?io?i?/ieo oiia Ia?aaeea?iaooy ia ?icaeoie ea???niaaiii? neooaoe?? a ?ioia?e ii?iaeiei? o ae?oae // Iaoa?. aeiiia?aeae Anaoe?a?inueei? iaoeiai -i?aeoe/ii? eiioa?aioe?? e?ea??a-noiiaoieia?a. - Iieoaaa, 1996.- N. 75 7. E?oiiee I. I., ?oaeueei A. ?. Aieea iaaeieeoiueiai i?e?iaeiiai na?aaeiaeua ia o?aaeai?noue coa?a o ae?oae (ia i?eeeaae? n??eiiinii? i?ia?ioe??) // I?iaeaie aeieia?/ii? aaciaee oa ea?iaaiiai eiio?ieth aeeiai?/ieo i?e?iaeii-oaoiiaaiieo nenoai: Iaoa?. i?aeia?iaeii? iaoeiai - i?aeoe/ii? eiioa?aioe??. - Ee?a, 1996. - N. 109-110 8. E?oiiee I. I. Iniaeeaino? ia?aa?ao ea???no coa?a o 3-o ??/ieo ae?oae, ui iaoeathoue o ?a??ii? i?iieneiaiai aeiaoaaiiy n??ee // Ioi?iia caei?ia’y ? aeiae?eey : Iaoa?. iaoe.-i?aeo. eiio . - Euea?a, 1996. - N. 112 9. E?oiiee I. I., Aiee?a Ae. I. Aiaeiaaee iieaciee ii?iaeieie ?ioa o ae?oae, ui i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa // No/ani? i?iaeaie noiiaoieia?? : Iaoa?. aeiiia. i?aei. iaoe. eiio. - Euea?a, 1996. - N. 52-53 10. E?oiiee I., Aacaooei A. Ioe?iea noaio oaa?aeeo oeaiei coa?a o ae?oae i?iieneiaeo ?a??ii?a Euea?aueie // Oace ?-ai I?aei. iaae. eiia?ano nooaeaio?a ? iieiaeeo a/aieo. - Oa?iii?eue, 1997. - N. 81 11. ?oaeueei A. ?., Niiey? I. ?., E?oiiee I. I. Eiioeaioe?y iaaeeei-aaieia?/ieo aeine?aeaeaiue a iaaeao oa?eoi??? Cao?aeiiai ?a??iio Oe?a?ie // No/ania aeieia?y ? aeieia?/ia iaoieia?y ethaeeie : Iaoa?. Oe?a?inueei - iieuenueeiai nai?ia?o. - Euea?a, 1997. - N. 122-124 12. E?oiiee I. I. ?iciianthaeaeai?noue oa ?ioaineai?noue ea???no oei/aniaeo coa?a o ae?oae i. Iiaiyai??anueea // Aeooaeuei? i?iaeaie noiiaoieia???. Iia? iaoiaeeee oa oaoiieia?? : Iaoa?. iaoeiai-i?aeo. eiio. - Euea?a, 1998. - N. 80-81 13. Krupnyk N., Bezvushko E. Scutecznosc laku szczelinowego Helioseal w profilaktyce prochnicy zebow u dzieci // Profilaktyka, Biomaterialy w stomatologii . - Miedzynarodova Konferenciya . - Poznan , 1997. - P. 56 14. Krupnyk N. Environmental influence in Oral Health // Counsil of European Chief Dental Officers. - Warsaw , 1997. - P. 79-81 15. Smolyar N., Rudko G., Krupnyk N. Ecological and Stomatological Problems of the West Region of Ukraine // Fogarty International Center Environmental Research Forum. - Lviv , 1997. - P. 26-27 16. Krupnyk N., Bezvushko E. Children’s caries problems and ecological influences in the West Region of Ukraine // J. Dent. Research (IADR Abstracts). - 1998. - Vol.77- P. 713 AIIOAOe?ss E?oiiee I.I. Ia??oiooaaiiy i?i?o?eaeoeee ea???no coa?a o ae?oae, ye? i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.22 - noiiaoieia?y. - Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai, Euea?a,1999. O iaoeia?e ?iaio? ocaaaeueiththoueny ?acoeueoaoe aeaieo i?i o?aaeai?noue coa?a ea???nii oa iniaeeaino? eiai ia?aa?ao o ae?oae, ye? i?iaeeaathoue o ?a??ii? n??/aiiai ae?iaieoeoaa. Iaaiaeyoueny ?acoeueoaoe a?io?i?/iiai oa ?ioiieia?/iiai aeine?aeaeaiiy ci?oaii? neeie ianoaaeaieo ae?oae. Anoaiiaeaii, ui aeieia?/ia neooaoe?y o ?a??ii? aeine?aeaeaiue nooo?ai aieeaa? ia ?icaeoie ea???no coa?a o ae?oae. Cai?iiiiiaaii oa ai?iaaaeaeaii eiiieaen i?io?eaeoe/ieo caoiae?a aeey ae?oae, ye? i?iaeeaathoue o n??eiiini?e aaii?ia?ioe??, yeee aeeth/a? a?iaaii? noeioeyoi?e. I?ia?aei? ?acoeueoaoe aeena?oaoe?? ciaeoee i?aeoe/ia ai?iaaaeaeaiiy a noiiaoieia?/i? iie?ee?i?ee. I?eaiaeyoueny aeai? i?i ?o aoaeoeai?noue i?e i?iaaaeaii? i?io?eaeoe/ieo caoiae?a. Eeth/ia? neiaa: caa?oaeiaiiy aeiae?eey, ae?oe a?oie aenieiai ?eceeo ?icaeoeo ea???no, ci?oaia neeia, i?io?eaeoeea. AIIIOAOeEss E?oiiue I. I. Iainiiaaiea i?ioeeaeoeee ea?eana coaia o aeaoae, i?iaeeaathueo a ?aaeiia i?iecaiaenoaa na?u. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.22 - noiiaoieiaey. - Eueaianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. Aeaieea Aaeeoeeiai, Eueaia, 1999. Oeaeueth aeaiiiai enneaaeiaaiey auei ia iniiaaiee eco/aiey ninoiyiey oaa?aeuo oeaiae coaia, a oaeaea iniaaiiinoae eeeie/aneiai oa/aiey caaieaaaiey o aeaoae, i?iaeeaathueo a ?aaeiia i?iecaiaenoaa na?u, ?ac?aaioaoue yooaeoeaiue eiiieaen i?ioeeaeoe/aneeo ia?ii?eyoee, aaeaioe?iaaiiue aeey aeaoae aeaiiiai ?aaeiia. I?iaaaeaii eeeie/aneia ianeaaeiaaiea 867 aeaoae, i?iaeeaathueo a ?aaeiia aeiau/e na?u e 635 aeaoae eiio?ieueiie a?oiiu, o eioi?uo eco/aiu iniiaiua iieacaoaee ea?eana. Aeey ii?aaeaeaiey oaeoi?ia ?enea eco/aii aeaeaie/aneia ninoiyiea iieinoe ?oa o aeaoae, ioaeaeueiua iieacaoaee niaoaiiie nethiu, oa?aeoa?ece?othuea aa ieia?aeece?othuoth ooieoeeth (?I, ayceinoue, eiioeaio?aoeeth eaeueoeey, iee?ie?enoaeecaoeeth, ieia?aeece?othuee iioaioeeae), a oaeaea eiioiieiae/aneee oii. Ioeaieaay yeieiae/aneoth neooaoeeth a ?aaeiia, onoaiiaeaii oaaee/aiea o?iaiy ?yaea oyaeaeuo iaoaeeia a ii/aao ii n?aaiaieth n AAeE, a oaeaea i/aiue ieceay, ii n?aaiaieth n ii?iie, eiioeaio?aoeey ooi?a, eiaea e a?iia a ieoueaaie aiaea. Niioaaonoaaiii auyaeaiu aiiiaeueiua eiioeaio?aoeee naeioea, eaaeiey e oeeiea a ei?iaieiaeao. ?acoeueoaou eeeie/aneiai ianeaaeiaaiey iieinoe ?oa o aeaoae eco/aaiiai ?aaeiia iieacaee aunieea iieacaoaee ?ani?ino?aiaiiinoe e eioaineaiinoe ea?eana, eae iiei/iuo, oae e iinoiyiiuo coaia, ii n?aaiaieth n eiio?ieueiie a?oiie. I?e aiaeeca aeoeaiinoe ea?eiciiai i?ioeanna onoaiiaeaii, /oi ii/oe o iieiaeiu aeaoae iniiaiie a?oiiu ano?a/athoueny iiiaeanoaaiiua ea?eiciua ii?aaeaiey, a o 34,81 % ec ieo aeeaaiinoe?iaaii ineiaeiaiiua oi?iu ea?eana. ?acoeueoaou eco/aiey ea/anoaa ooiaea ca iieinoueth ?oa naeaeaoaeuenoaotho, /oi aieueoeinoai aeaoae, i?iaeeaathueo a ?aaeiia aeiau/e na?u, ia?aaoey?ii ooaaeeaatho ca iieinoueth ?oa e o ieo i?aiaeaaeaao iaoaeiaeaoai?eoaeueiia e ieioia aeaeaie/aneia ninoiyiea niaeanii eiaeaena Oaaei?iaa-Aieiaeeeiie. I?eaaaeaiiua aeaiiua enneaaeiaaiey niaoaiie nethiu, naeaeaoaeuenoaotho ia eciaiaieyo aa iieacaoaeae o aeaoae, i?iaeeaathueo a ?aaeiia i?iecaiaenoaa na?u. Onoaiiaeaii, /oi niaoaiay nethia o yoeo aeaoae oa?aeoa?ecoaony neaaieeneie ?aaeoeeae, aunieeie iieacaoaeyie ayceinoe e oaaea/aieai niaea?aeaiey eaeueoeey. A niaoaiiie nethia i?aiaeaaeaao ??? oei iee?ie?enoaeecaoeee, a aa ieia?aeece?othuee iioaioeeae oa?aeoa?ecoaony eae ieceee. Eco/aiea eiioiieiae/aneiai noaoona iieinoe ?oa o aeaoae, i?iaeeaathueo a yeieiae/anee iaaeaaii?eyoiii ?aaeiia, iieacaei, /oi o?iaaiue SIgA a niaoaiie nethia cia/eoaeueii ieaea, /ai o aeaoae eiio?ieueiie a?oiiu, a eiioeai?aoeey IgA e IgM ianeieueei auoa. ?acaeoea ea?eiciiai i?ioeanna nii?iaiaeaeaaoueny nieaeaieai eo o?iaiy a niaoaiiie nethia. Oaeei ia?acii, o/eouaay ?acoeueoaou eeeie/aneeo, aeioeie/aneeo, eiioiieiae/aneeo enneaaeiaaiee, a oaeaea iniaaiiinoe yeieiae/aneie neoeaoeee a ?aaeiia enneaaeiaaiee, iaie ?ac?aaioaii e aiaae?aii eiiieaen i?ioeeaeoe/aneeo ia?ii?eyoee, aeeth/athuee i?aia?aou eaeueoeey e ooi?a, aeiaaiiua noeioeyoi?u (’’Aeio?eo N’’ e ’’Aeiaeaio-2’’ ), a oaeaea iao/aiea i?aaeeueiiio ooiaeo ca iieinoueth ?oa. Yooaeoeaiinoue i?aaeeiaeaiiiai i?ioeeaeoe/aneiai eiiieaena eco/aeanue /a?ac 2,5 aiaea o 120 aeaoae, o eioi?uo ii?aaeaeaii i?e?ino eioaineaiinoe ea?eana ii iieacaoaeyi: eic, eii, EIAc e EIAi, eciaiaiey ieia?aeece?othuae ooieoeee niaoaiiie nethiu, a oaeaea o?iaiaiue eiioiiaeiaoeeiia a niaoaiiie nethia. Onoaiiaeaii, /oi ca ia?eiae iaaethaeaiey, i?e?ino ea?eiciuo coaia e ea?eiciuo iieinoae o aeaoae, eioi?ui i?iaiaeeeenue i?ioeeaeoe/aneea ia?ii?eyoey, cia/eoaeueii ieaea, /ai o aeaoae eiio?ieueiie a?oiiu. ?aaeoeoeey ea?eana iiei/iuo coaia ninoaaeea - 62,44 %, a iinoiyiiuo - 49,82 %. E?iia yoiai i?iecioee cia/eoaeueiua eciaiaiey ieia?aeece?othuae ooieoeee niaoaiie nethiu. Iinea i?ioeeaeoeee a iae i?aiaeaaeaao ?? oei iee?ie?enoaeecaoeee, a ieia?aeece?othuee iioaioeeae oa?aeoa?ecoaony eae oaeiaeaoai?eoaeueiue. Oaeaea onoaiiaeaii, /oi iinea i?iaaaeaiey i?ioeeaeoe/aneeo ia?ii?eyoee, iaaethaeaaony oaaee/aiea o?iaiy enneaaeoaiuo a?oii eiioiiaeiaoeeiia. Iaeaieaa au?aaeaiiui anoue oaaee/aiea SIgA e IgA (a 1,5 ?aca). ?acoeueoaou aeenna?oaoeee iaoee i?aeoe/aneia i?eiaiaiea ia ?aaeiaeueiii e iaeanoiii o?iaiyo, a noiiaoieiae/aneeo iieeeeeieeao Eueaiaa, Oaeai?iaea e Oa?iiiiey. I?eaaaeaiu aeaiiua ia eo yooaeoeaiinoe i?e i?iaaaeaiee i?ioeeaeoe/aneeo ia?ii?eyoee. Iniiaiua iao/iua iieiaeaiey aeenna?oaoeee aeeth/aiu a eaeoeeiiiue iaoa?eae e eniieuecothony ia i?aeoe/aneeo caiyoeyo ni nooaeaioaie ia eaoaae?ao noiiaoieiaee aeaoneiai aic?anoa Eueaianeiai, Oa?ueeianeiai e Aeiiaoeeiai iaaeeoeeineeo oieaa?neoaoia. Eeth/aaua neiaa: caa?yciaiea ie?oaeathuae n?aaeu, aeaoe a?oiiu ?enea ?acaeoey ea?eana, niaoaiiay nethia, i?ioeeaeoeea. SUMMARY Krupnyk N.M. Ground the caries prophylaxy in children live in sulphur mining region. - Manuscript. Thesis for getting a Candidate of Medical Sciences' Degree by speciality 14.01.22 - Stomatology. - L'viv State Medical University, Danylo Galitsky name for, L'viv, 1999. The scientific work is being defended on the base of data about caries frequency and intensivity, peculiarity of it's clinical caurse in children from sulphurmining region. The motivated results of biochemical and immunological research of mixed saliva are being given. It was experimentally defined that ecological situation in essentialy spread the teeth caries in cyildren. The prophylactic measures that included biogenic stimulants are being suggested and carried out. The results of the work have been found a practical utility in stomatological polyclinics. The data of it's effectiveness in the prophylaxy. Key words: environment pollution, high caries risk children, mixed saliva, prophylaxy.

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