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Обгрунтування і розробка методів консервативного лікування хворих на неспецифічний виразковий коліт (клініко-експериментальне дослідження): Автореф. д

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

AA?ACA I?iaeue Ieoaee?aia

OAeE: 616.348-002.44-0.85

IAA?OIOOAAIIss ? ?IC?IAEA IAOIAe?A

EIINA?AAOEAIIAI E?EOAAIIss OAI?EO

IA IANIAOeEO?*IEE AE?ACEIAEE EIE?O

(ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy)

14.01.02 – aioo??oi? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
aano?iaioa?ieia?? IIC Oe?a?ie, i. Aei?i?iiao?ianuee

Iaoeiaee eiinoeueoaio:

/e.-ei?. AII Oe?a?ie, aeieoi? iaaee/ieo iaoe,

i?ioani? O?E?IIA TH??e Ieaenaiae?iae/ – aee?aeoi? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aano?iaioa?ieia??

Io?oe?ei? iiiiaioe:

Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe,

i?ioani? AeAEIAEI I?ia Oaaei??aia – Oa?e?anueea iaaee/ia aeaaeai?y
i?neyaeeieiiii? ina?oe, caa. eaoaae?ith aano?iaioa?ieia??

Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe,

i?ioani? OAI?INO?IEA Aieiaeeie? Ieeieaeiae/ – Oa?e?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao, caa. eaoaae?ith oaeoeueoaonueei? oa?ai??

Aeieoi? iaaee/ieo iaoe,

i?ioani? ?AOAO?EIA TH??e ?aaiiae/ – Caii??cueeee ?inoeooo oaeineiiaeaiiy
e?ea??a, caa. eaoaae?ith aano?iaioa?ieia??

I?ia?aeia onoaiiaa: ?inoeooo oa?ai?? AII Oe?a?ie, a?aeae?e
aano?iaioa?ieia?? (i. Oa?e?a)

Caoeno aeena?oaoe?? a?aeaoaeaoueny ”9”aa?aniy1999 ?. i 13.30 ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a, i?. Eai?ia, 4)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
iaaee/iiai oi?aa?neoaoo ca aae?anith: 310022, i. Oa?e?a, i?. Eai?ia, 4

Aaoi?aoa?ao ?ic?neaiee “15”/a?aiy1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee, eaiaeeaeao iaaee/ieo
iaoe,

aeioeaio

E.?.Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie aeena?oaoe??. O?ii?/i? ianiaoeeo?/i? caiaeuei?
caoai?thaaiiy oianoi? eeoee ? iaeieie c iaea?eueo ?iciianthaeaeaieo
aioo??oi?o oai?ia a Oe?a?i? (TH.I.O?e?iia ?c ni?aaao., 1997), na?aae
yeeo cia/ia ieoiia aaaa iaeaaeeoue iaeoyae/iio c ieo – ianiaoeeo?/iiio
ae?aceiaiio eie?oo (IAE). A oie /an, ye o na?o? oea caoai?thaaiiy ia?
?iciianthaeaeai?noue o na?aaeiueiio 10 aeiaaee?a ia 100 oen. ianaeaiiy ?
ua ui??/ii aia?oa ?a?no?o?oueny 10 aeiaaee?a ia oeth ae e?euee?noue
ianaeaiiy (A.E.A?aaaiaa, E.I.Iyaeiaa, 1994; A.?.Ceaoeeia, A.A.Aaeioniaa,
1996; A.A.Ia?aaea??e, I.A.Ae/eiaa, E.A.Aeoaea?ue, 1997; TH.A.Aaeoaeo?n ?
ni?aaao., 1998; C.M.Stonnington et al, 1994; A.Ekbom et al, 1998), o
iao?e e?a?i? iieaciee ?iciianthaeaeaiino? IAE noaiiaeoue 28,4 ia 100
oen. ianaeaiiy c ui??/iei i?e?inoii aia?oa aeyaeaii? caoai?thaaiino? –
3,5. I?e/iio, o ??cieo ?aa?iiao oe? iieacieee cia/ii a?ae??ciythoueny;
?iciianthaeaeai?noue eieeaa?oueny a?ae 3,4 o Aei?i?iiao?ianuee?e iaeano?
aei 62,3 o Eoaainuee?e, a aia?oa aeyaeaia caoai?thaai?noue – a?ae 0,8 o
?iaainuee?e aei 7,1 o Aei?i?iiao?ianuee?e iaeano? (TH.I.O?e?iia oa ?i.,
1997).

Oaiaeaioe?y aei ca?eueoaiiy caoai?thaaiino? ia IAE na?aae in?a
i?aoeacaeaoiiai a?eo, a oaeiae na?aae ae?oae ? i?aee?oe?a, i?ia?anoth/ee
ia?aa?a c /anoeie ?aoeeaeeaaie oa iaaacia/ieie aeey aeeooy
oneeaaeiaiiyie, cia/ia ?iaae?aeecaoe?y oa nia?oi?noue iaoiiaeththoue
aaeeea iaaeeei-nioe?aeueii-aeiiii?/ia cia/aiiy oe??? i?iaeaie
(A.E.Ao?i?no?iaa, 1990; A.A.Ia?aaea??e, N.I.Oea/, I.A.Ae/eiaa, 1990;
I.O.Aeaeiaei, I.?.ssaeo/ainueeee, I.ss.Aaaae, 1991; ?.I.Iaeei, 1997;
TH.A.Aaeoaeo?n, 1997; A.I.Oai?ino?iea ? ni?aaao., 1998; S.C.Oruelove,
1997; H.Dianagi et al., 1997; C.Oysk et al., 1998, M.Cottone et al.,
1998), yea aeiaaa? eiiiaoaioe?? ye oa?aiaao?a, oae ? o??o?a?a.

Nai?/ania ae?aaiinoeea IAE, i?iaiicoaaiiy eiai ia?aa?ao oa aea??
aoaeoeaii? oaeoeee e?eoaaiiy caeeoathoueny neeaaeieie caaaeaiiyie ?
iio?aaothoue oaeineiiaeaiiy. Iayai?noue aaeeei? e?eueeino? oaeoi??a, ye?
i?eeiathoue o/anoue o iaoiaaiac? IAE, a?aenooi?noue /?oeiai oyaeaiiy i?i
iaoai?ci ?icaeoeo eiai, iaoiiaeee canoinoaaiiy ??ciiiai?oieo niinia?a
e?eoaaiiy, i? iaeei c yeeo ia ? oni?oiei (A.A.Ee?eei, 1997;
O.A.E?aa/aiei, 1998; E.A.Aeaaeueei ? ni?aaao., 1997).

Oi?iaeiaae inoaii?o ?ie?a o iaoiaaiac? IAE nooo?aa cia/aiiy aeciaia ca
?ioiieie ii?ooaiiyie (A.E.Ao?i?no?iaa, 1990-1995; ?.E.Aeaaeaiei, 1991;
G.Gebbers, H.Otto, 1990), aea ?o ca’ycie i?e IAE c ?ioeie necoaiaie
?aaoeyoe?? (iae?i-aoii?aeueiith, aeeoociith aiaeie?eiiith,
oeeoie?iiaith) ua ia aecia/aii. ?ioiiei?aeoe?y, yea cae?enith?oueny i?e
IAE ia aoaeoi?iiio ??ai?, aeyaeeany iaaeinoaoiuei aoaeoeaiith. Iaa?aeiia
oaeiae i?ia?aeia eaiea o iaoiaaiac? IAE, a?aeiiaeaiiy yei? ni?eyei a
oaeaee?e ?aa?an?? caoai?thaaiiy oa no?ee?e ?ai?n??.

I?eae?eyth/e aaeeeo oaaao aeenaaeoa??icai ye aeooaeuei?e i?iaeai?
iaaeeoeeie (A.A.Ai?iaue?a ? ni?aaao., 1994-1998; A.I.Aiiaea?aiei ? ?i.,
1994-1998; E.E.Naaeoeeay ? ?i., 1996; A.A.Oaiaea?ia, 1996-1998;
R.B.Sartor, 1995-1997), a/ai? a oie aea /an ia aecia/eee ?ieue
i?e?ioei?e o naiiaaiac? IAE ? aoaeoeai?noue i?ia?ioee?a ye a oe?eiio o
e?eoaaii? IAE, oae ? uiaei a?aeiiaeaiiy aoa?ico oa ?ioi?oaoo
(E.A.Aeaaeueei ? ni?aaao., 1986; A.A.Ee?eei, 1997; E.E.Oaeeo ? ni?aaao.,
1998; ? ?i.). Anoaiiaeaiiy aaiaoe/ii? aeaoa?i?iiaaiino? ?ioiieia?/ii?
?aaeoeaiino? i?aai?cio oa ?iaeea?aeoaeueiiai aeioiio o oiano?e eeooe?
iaei aieeioei ia iie?auaiiy e?eoaaiiy oeueiai eiioeiaaioo oyaeeeo
oai?eo. Ia aeei?enoaia iiaeeea?noue iie?ioaiiy ?acoeueoao?a e?eoaaiiy
canoinoaaiiyi ?ioiii?aia?ao?a, iaioeaeieo i?aia?ao?a, ?ia?a?oi??a
i?ioa?iac, oeeoie?i?a, ye? inoaii?i /anii ana oe?oa canoiniaothoueny o
ee?i?/i?e iaaeeoeei? ??cieo oao?a (I.I.Oaoa?, 1995; E.A.Aaieianueea,
E.A.Eiaaeue/oe, 1995-1996, A.?aoooon ? ni?aaao., 1996; A.I.Aooaiei,
1997, 1998). On? oe? /eiieee oa no??ieee ?icaeoie ?yaeo iaoe –
aiaeie?eiieia?? oeoieiai-eeoeiaiai o?aeoo, a?ieia??, ?ioiieia??,
oeeoie?iieia?? niiioea? aei iiooeo iiaiai, a?eueo aoaeoeaiiai iai?yieo o
e?eoaaii? IAE, ui aeciaii aeooaeueiei ? aena?oeaii o aeai?e ?iaio?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie IIC Oe?a?ie oa onoaiiae.
Aeena?oaoe?y aeeiiaia o a?aeiia?aeiino? aei ieaio iaoeiai-aeine?aeieo
?ia?o Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo aano?iaioa?ieia?? ?
i?noeoue o?aaiaioe aeaio iaoeiai-aeine?aeieo oai, ye? aeeiioaaeeny a
Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo? aano?iaioa?ieia?? ca
i?iaeoii ? i?ae ea??aieoeoaii aeena?oaioa, ca ?acoeueoaoaie aaeocaaiai
eiieo?no oa ca caiiaeaiiyi IIC Oe?a?ie: “?ac?aaioea iaania/eaathuae
aeinoeaeaiea noieeie ?aiennee iiaie iaaeeoeeineie oaoiieiaee
aeeooa?aioee?iaaiiiai ea/aiey e ?aaaeeeoaoeee aieueiuo ianiaoeeoe/aneei
ycaaiiui eieeoii a caaeneiinoe io ninoiyiey aeeooociie yiaeie?eiiie
nenoaiu”; iiia? aea?aeaaii? ?a?no?aoe?? 0193U007442, oeo? oaie IE.91.82,
oa?i?i aeeiiaiiy – 1992-1994 ??.; “Oaeineiiaeaiiy e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o oeyoii noeioeyoe?? aiaeiaaiieo
?aaoeyoi??a ?ioi?oaoo”, iiia? aea?aeaaii? ?a?no?aoe?? 0197U004614, oeo?
oaie 25.01.004.97, oa?i?i aeeiiaiiy – 1997-1998 ??.

Iaoa aeine?aeaeaiiy. I?aeaeueoe aoaeoeai?noue eiina?aaoeaiiai e?eoaaiiy
oai?eo ia ianiaoeeo?/iee ae?aceiaee eie?o oeyoii ooi/iaiiy eiai
iaoiaaiaco ? ?ic?iaeaiiy eiiieaeno iaoiaaiaoe/ii iaa?oioiaaieo
e?eoaaeueii-i?io?eaeoe/ieo caoiae?a.

Caaea/? aeine?aeaeaiiy. Aeey aeinyaiaiiy oe??? iaoe iinoaaeai? oae?
caaea/?:

1. Ocaaaeueieoe aeina?ae eiina?aaoeaiiai e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o, oaeineiiaeeoe ee?i?ei-noaoenoe/io
eeaneo?eaoe?th eiai ia aac? ?ioi?iaoe?eii-i?ia?aiieo oaoiieia?e.

2. ?ic?iaeoe ?ioi?iaoeai? ia?iaaceai? ae?aaiinoe/i? e?eoa???
ianiaoeeo?/iiai ae?aceiaiai eie?oo, i?eaeaoi? aeey aecia/aiiy oace,
aaaeeino?, oneeaaeiaiiy oai?iae, aeey aaaaoi?aciaiai aeei?enoaiiy o
i?ioean? aeeiai?/iiai niinoa?aaeaiiy ca oai?eie.

3. Ooi/ieoe iniiai? iaoiaaiaoe/i? eaiee ianiaoeeo?/iiai ae?aceiaiai
eie?oo, ?o aca?iicaeaaei?noue, ?acenoaioi?noue.

4. Noai?eoe aaeaeaaoio iaaeeei-a?ieia?/io iiaeaeue ae?aceiaiai eie?oo
aeey c’ynoaaiiy ?aii?o aoai?a iaoiaaiaco ianiaoeeo?/iiai ae?aceiaiai
eie?oo, ?ie? a iueiio iaoai?ci?a ia?aiai-aoii?aeueii?,
?ioanoeiiai?iiiaeueii? oa ?ioiii? ?aaoeyoe?? ooieoe?e i?aai?cio.

5. Aea/eoe aoaeoeai?noue ianiaoeeo?/ii? ?ioiinoeioeyoe?? aaiaaeiaoe?iii
o oai?eo ia ianiaoeeo?/iee ae?aceiaee eie?o.

6. C’ynoaaoe cia/aiiy iaioeaeieo e?ea?nueeeo cania?a iaoo?aeueiiai oa
neioaoe/iiai iioiaeaeaiiy aeey a?aeiiaeaiiy ?ioiiiai noaoono, aoa?ico
oianoi? eeoee oa i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o.

7. ?ic?iaeoe iia? aoaeoeai? niiniae e?eoaaiiy oai?eo ia ianiaoeeo?/iee
ae?aceiaee eie?o, a?oiooth/enue ia a?aeiiaeaii? nenoaiiiai ?ioi?oaoo oa
aoa?ico oianoi? eeoee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. I?e ae??oaii? i?iaeaie
ae?aaiinoeee ? e?eoaaiiy ianiaoeeo?/iiai ae?aceiaiai eie?oo aia?oa
ae?noaee iiaeaeueoee ?icaeoie iia? iai?yiee iaaee/ii? iaoee “Aiaeie?eiia
aano?iaioa?ieia?y”, “Oeeoie?iieia?y” oa “Oeeoie?iioa?ai?y”, “aeena?ic oa
i?ia?ioeee”.

Aia?oa ia iniia? ee?i?ei-aenia?eiaioaeueiiai aea/aiiy noi?ioeueiaaia
eiioeaioe?y iaoiaaiaco ianiaoeeo?/iiai ae?aceiaiai eie?oo ye
aeanoaa?e?caoe?? aca?iica’yce?a o an?o aea/aieo ?aaoeyoi?ieo nenoaiao
(iae?i-aoii?aeuei?e, ?ioanoeiiai?iiiaeuei?e, ?ioii?e, i?e?iai?e) c
ii?ooaiiyi ia?eoaoo ia eeoa i?ae ieie, a e ona?aaeei? ie?aieo aeie?a ia
oii? niaaeei?iii? noeeueiino?, yea iaoiiaeth? i?aeaeuaiee ?ecee ?icaeoeo
ianiaoeeo?/iiai ae?aceiaiai eie?oo oa aaiaoe/ii iaoiiaeaio neaae?noue
a?aeiiaethaaeueieo i?ioean?a, ui ?aae?co?oueny i?e ii?aeiaii?
iani?eyoeeaeo aeci- oa aiaeiaaiieo /eiiee?a.

Aia?oa aenia?eiaioaeueii ia noai?ai?e iaaeeei-a?ieia?/i?e iiaeae?
ae?aceiaiai eie?oo anoaiiaeai? iniaeeaino? oaciaeo ci?i
iae?i-aoii?aeueii?, aeeoocii-aiaeie?eiii? oa ?ioiii? ?aaoeyoi?ieo eaiie
aiiainoaco ia aeiee?i?/iiio aoai? oai?iae ? aeyaeaia o?eaae?noue
oaiiiaio a?aeiiae ?aaoeyoe?? ye i?neyae?? aoaeue-yeiai iaoiaaiiiai
/eiieea, iniaeeaa o?aceea?noue ? ?acenoaioi?noue aei a?aeiiaeaiiy
ai?iiiaeueii? oa ?ioiii? eaiie iaoiaaiaco.

Ee?i?ei-aenia?eiaioaeueieie aeine?aeaeaiiyie anoaiiaeaia
aca?iieiiieaiaioa?i?noue i?e ianiaoeeo?/iiio ae?aceiaiio eie?o? iniiaieo
?aaoeyoi?ieo eaiie aiiainoaco i?aai?cio – ia?aiai-aoii?aeueii?,
?ioanoeiiai?iiiaeueii?, ?ioiii? oa i?e?iaii?, ye? iia’ycai? a iaeia
?aaoeyoi?ia e?eueoea, ? a?ae ?aaa?e?oaoe?? yeeo, iniaeeai a?ae ?ioiii?,
caeaaeeoue oni?o e?eoaaiiy oe??? oai?iae oa o?eaae?noue ?ai?n??.

Aia?oa i?e ianiaoeeo?/iiio ae?aceiaiio eie?o? oaeoi?iei aiae?cii
anoaiiaeaia nooue ii?ooaiiy aioo??oiuei? i?aai?caoe?? nenoaiiiai
?ioi?oaoo i?e oi?ioaaii? aaeaeaaoii? ?ioiii? a?aeiia?ae?, ?ieue
oeeoie?i?a o noaiiaeaii? oa c?oeioaaii? eiiia?aoeaieo a?aeiioaiue i?ae
?ioiieiiiaoaioieie ee?oeiaie oa aca?iica’yceo ?o c aiaeiaaiieie
o?c?ieia?/ii aeoeaieie niieoeaie (ai?iiiaie, iae?iiaae?aoi?aie ? ?i.).

Aeieacaia iiaeeea?noue oeeoie?iaie cae?enithaaoe e?eoaaeueiee aoaeo i?e
ianiaoeeo?/iiio ae?aceiaiio eie?o? caaaeyee a?aeiiaeaiith ?aaoeyoi?ii?
eaiee nenoaiiiai ?ioi?oaoo oa iie?auaiith ?ioi?iaoe?eiiai iai?io i?ae
ee?oeiaie ??cieo nenoai ?aaoeyoe??.

??ciia?/ii aena?oeaia ?ieue nenoaiiiai oa eieaeueiiai ?ioi?oaoo aeey
a?aeiiaeaiiy aoa?ico o oiano?e eeooe? ? aca?iicaeaaei?noue ?o o
iaoiaaiac? oa naiiaaiac? ianiaoeeo?/iiai ae?aceiaiai eie?oo.

Ia oeueiio i?aea?oio? caii/aoeiaaii iiaee iai?yi o e?eoaaii?
aano?iaioa?ieia?/ieo oai?eo – aooie?ioie?iioa?ai?th noai?aiiyi iiaiai
aooieia?/iiai niiniao e?eoaaiiy ianiaoeeo?/iiai ae?aceiaiai eie?oo ia
i?eioeeiiai iiaeo canaaeao ?ioiiei?aeoe?? – a?aeiiaeaiiyi aeanii?
?ioii?aaoeyoi?ii? eaiee, yeee ia ia? iia?/ieo yaeu (iaoaio Oe?a?ie ?
23831 A).

C’yniaaii, ui ?ioa?eaee?ie (IL-1 ? IL-2), aeeth/ath/enue i?e oi?ioaaii?
?ioiii? a?aeiia?ae? aei iaeaaaeeea?oiai aeieo ?ioiii? eiiiaoaioe??,
caaacia/othoue aeeiai?ci ? aenieo aeoeai?noue, caeaoi?noue aei
a?aeiiaethaaeueieo i?ioean?a iniiaieo eiiiiiaio?a eiai, ui oi?io?
ni?eyoeeaee ia?aa?a ianiaoeeo?/iiai ae?aceiaiai eie?oo, ciaioaiiy ?o
i?iaeoeoe?? ? ?aoeaioe?? iaoiiaeth? aeeth/aiiy aei iaio aaaeeeaeo aeie?a
oa ni?e/eiy? oyaeeee ia?aa?a ianiaoeeo?/iiai ae?aceiaiai eie?oo,
o?ii?caoe?th eiai.

Anoaiiaeaii, ui a oiiaao iaaeinoaoiuei? i?iaeoeoe?? oa ?aoeaioe?? IL-1
oa IL-2 i?e ianiaoeeo?/iiio ae?aceiaiio eie?o? aooie?ioie?iioa?ai?y ae??
aiaeii/an ye cai?nia, ? ye noeioethth/a, ?iaeoeoth/e ?aaa?e?oaoe?th
neiii?iiaoiaaii? eaiee ?ioiii? nenoaie, ui ni?ey? oaeaee?e ?aa?an??
oai?iae c ii?iae?caoe??th iieaciee?a caiaeaiiy, aeano?oeoe?? oa aea?a??.

Aia?oa anoaiiaeaii, ui aiaeioieneeic i?e ianiaoeeo?/iiio ae?aceiaiio
eie?o? coiiaeth?oueny i?aeaeuaiiyi eiioeaio?aoe?? ?yaeo
aano?i?ioanoeiaeueieo ai?iii?a (aano?eio, N-iaioeaeo), aiaeiaaiieo
o?c?ieia?/ii aeoeaieo niieoe (?inoe?io, a?noai?io, ei?oecieo,
?aeiai-aia??iiaeueiiai aioeaaio, IgE), ui iaa?oioiao? aeioe?euei?noue
aioa?ini?aoe?? oa aeac?ioieneeaoe?eieo caoiae?a.

?ic?iaeaii i?ea?iaeueiee niin?a e?eoaaiiy oai?eo ia ianiaoeeo?/iee
ae?aceiaee eie?o c canoinoaaiiyi a?o/eciyieo i?aia?ao?a – iaoo?aeueiiai
iaioeaeiiai i?aia?aoo nieai?io oa aioa?ini?aoe?? ea?atheicith (iaoaio
Oe?a?ie ? 9037).

Ia aac? ?ioi?iaoe?eii-i?ia?aiieo oaoiieia?e noai?aia oi?o?eiaaia
ee?i?ei-noaoenoe/ia eeaneo?eaoe?y ianiaoeeo?/iiai ae?aceiaiai eie?oo.
?ic?iaeai? ?ioi?iaoeai? ia?iaaceai? iaoiaee ae?aaiinoeee: aecia/aiiy
ia’?io e?iaiao?aoe ?c oeoieiai-eeoeiaiai o?aeoo, oeeoieia?/ii?
ae?aaiinoeee ianiaoeeo?/iiai ae?aceiaiai eie?oo, niin?a aeine?aeaeaiiy
eeoee, noai?ai? i?eno?i? aeey ae?aaiinoeee ? e?eoaaiiy oianoi? eeoee,
iiaecio ?yaeo c ieo i?aeoaa?aeaeothoue 7 aaoi?nueeeo na?aeioeoa oa 7
iaoaio?a Oe?a?ie ia aeiaoiaee.

Iiaeie yaeythoueny ? ?acoeueoaoe ee?i?/ii? ai?iaaoe?? noai?aieo niinia?a
oa canoinoaaiiy o e?eoaaeueieo eiiieaenao i?e ianiaoeeo?/iiio
ae?aceiaiio eie?o? iaioeaeieo i?aia?ao?a (aeoiaaa?io, aeaea?a?io,
a?a?nieo, naiaeinoaoeio, eiio?eeaeo), a?inii?eio oa ea?atheice, c yeeo
a?a?nie, a?inii?ei oa ea?atheica noai?ai? a Oe?a?i?.

Oaeei /eiii, on? caaea/? aeeiiai?, ?ic?iaeaiee iiaee ia?niaeoeaiee
iai?yi o e?eoaaii? ianiaoeeo?/iiai ae?aceiaiai eie?oo oa iecea
oai?aoe/ieo iieiaeaiue, noeoii?noue yeeo iiaeia eaae?o?eoaaoe ye aaaiia
aeinyaiaiiy o ?icaeoeo ee?i?/ii? aano?iaioa?ieia?? – aiaeie?eiii?
aano?iaioa?ieia??, oeeoie?iieia?? oa oeeoie?iioa?ai??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Noai?aia ia oa?ai?
?ioi?iaoe?eii-i?ia?aiieo oaoiieia?e oi?o?eiaaia ee?i?ei-noaoenoe/ia
eeaneo?eaoe?y ianiaoeeo?/iiai ae?aceiaiai eie?oo o ?aieao oi?o?eiaaii?
ee?i?ei-noaoenoe/ii? eeaneo?eaoe?? oai?ia i?aai?a o?aaeaiiy ni?ey?
a?eueo ?aiiueiio ? oi/iiio ?ici?ciaaaiith ? i?aeaeuaiith aoaeoeaiino?
e?eoaaiiy oe??? oyaeei? iaoieia??, iie?auo? ye?noue ? eoeueoo?o
iaaee/iiai ianeoaiaoaaiiy oai?eo, aea? iiaeeea?noue i?iaiaeeoe
ia’?eoeaio aenia?oeco yeino? ae?aaiinoeee oa e?eoaaiiy oai?eo, aecia/aoe
eiie?aoi? aeo?aoe ia oai?iai o iaaee/ieo onoaiiaao aoaeue-yeiai ??aiy ?
a oe?eiio ii aaeoc?, aeeiioaaoe ieceo o?iainiai-aeiiii?/ieo iia?aoe?e,
ye? iaiao?aei? a oi?aae?ii? ? i?aai?caoe?? iaaee/ii? aeiiiiiae.

?ic?iaeai? iia? iaoiaee ae?aaiinoeee: aecia/aiiy ia’?io e?iaiao?aoe ?c
oeoieiai-eeoeiaiai o?aeoo, oeeoieia?/ii? ae?aaiinoeee ianiaoeeo?/iiai
ae?aceiaiai eie?oo, noai?ai? iia? i?eno?i? aeey ae?aaiinoeee oa
e?eoaaiiy oianoi? eeoee, ia ye? iaea?aeai? aaoi?nuee? na?aeioeoaa oa
iaoaioe, i?aeaeuothoue oi/i?noue ?ici?ciaaaiiy, iie?auothoue oaoi?/io
iniauai?noue e?ea?y, ni?eythoue i?aeaeuaiith aoaeoeaiino? e?eoaaiiy
oai?eo ia ianiaoeeo?/iee ae?aceiaee eie?o.

Ooi/iai? caaaeyee ee?i?ei-aenia?eiaioaeueiiio aeine?aeaeaiith iniiai?
eaiee iaoiaaiaco iiaeeaeththoue oyaeaiiy i?i iaoai?cie ?icaeoeo
caoai?thaaiiy ? iaoai?cie naiiaaiaco, a?aee?eaathoue iia? iiaeeeaino?
aeey e?eoaaeueiiai aieeao ye ia aoaeoi?iiio, oae ? ia ?aaoeyoi?iiio
??ai?.

?ic?iaeaia oaoiieia?y iaea?aeaiiy aooie?ioie?i?a ?c aeanieo
iiiiioeeaa?ieo ee?oei oai?iai ica?ith? e?ea?y aoaeoeaiei ?ioiiaeoeaiei
a?o/eciyiei aooieia?/iei i?aia?aoii, aeeth/aiiy yeiai aei e?eoaaeueiiai
eiiieaeno ?acii c aioa?ini?aoe??th, naeioaeueeii oa a?inii?eiii
caaacia/o? cia/ia i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o.

Noai?ai? iia? iaoiaee e?eoaaiiy ianiaoeeo?/iiai ae?aceiaiai eie?oo c
aeei?enoaiiyi a?o/eciyieo i?aia?ao?a – iaioeaeieo (nieai?i, a?a?nie),
i?ia?ioee?a (a?inii?ei) oa aooie?ioie?i?a – cia/ii i?aeaeuothoue
aoaeoeai?noue e?eoaaiiy, caaacia/othoue ?aaa?e?oaoe?th ?ioiii? nenoaie,
caaaeyee /iio aeinyaa?oueny o?eaaea ?ai?n?y caoai?thaaiiy.

Aeei?enoaiiy aooie?ioie?iioa?ai?? o oai?eo ia ianiaoeeo?/iee ae?aceiaee
eie?o aeicaiey? ciaioeoe aeice ai?iinae?oeeeao?a, ei?oeeinoa?i?aeieo
i?aia?ao?a, iaa?oue i?e oyaee?e oi?i? caoai?thaaiiy oieeiooe iia?/ieo
yaeu.

?ic?iaeai? iieacaiiy, i?ioeiieacaiiy, iaoiaeeee aeeiiaiiy cai?iiiiiaaieo
iaoiae?a e?eoaaiiy ni?eythoue ai?iaaaeaeaiith ?o o i?aeoe/io ioi?iio
caei?ia’y Oe?a?ie.

Noai?ai? o i?ioean? aeeiiaiiy aeena?oaoe?? aeacai? iiaiaaaaeaiiy
aeathoue iiaeeea?noue ia aeuiio ??ai? cae?enithaaoe ae?aaiinoeeo,
e?eoaaiiy oa i?io?eaeoeeo ?aoeeaeea?a caoai?thaaiiy, ui aeicaieeoue
cieceoe caoai?thaai?noue, oei/aniao iai?aoeacaeaoi?noue oa
?iaae?aei?noue, caiia?aoe o??o?a?/iiio e?eoaaiith, iie?aueoe ye?noue
aeeooy oai?eo ia ianiaoeeo?/iee ae?aceiaee eie?o.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. Ca iaoa??aeaie
aeena?oaoe?? aeey i?aeoe/ii? ioi?iie caei?ia’y aeaeaii 5 iaoiaee/ieo
?aeiiaiaeaoe?e, 8 ?ioi?iaoe?eieo eeno?a, ?ic?neaieo a iaeani? a?aeae?ee
ioi?iie caei?ia’y Oe?a?ie ? ai?iaaaeaeai? a e?eoaaeueii-i?io?eaeoe/ieo
onoaiiaao, io?eiaii 7 aaoi?nueeeo na?aeioeoa oa 7 iaoaio?a Oe?a?ie ia
aeiaoiaee. Iieiaeaiiy aeena?oaoe?? aeiaaaeai? aei a?aeiia o/aniee?a 29
eiia?an?a, eiioa?aioe?e, ieaioi?a oao?aoe?a Oe?a?ie, aeecueeiai oa
aeaeueiueiai ca?oa?aeaey, a oaeiae 5 can?aeaiue Aei?i?iiao?ianueeiai
iaeaniiai oa i?nueeiai oiaa?enoa aano?iaioa?ieia?a.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? o i?aeoe/io ?iaioo a?aeae?eaiue
? eaai?aoi??e Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo
aano?iaioa?ieia?? (aeo ai?iaaaeaeaiiy a?ae 04.04.99 ?.), Oe?a?inueeiai
IAe? iaaeeei-nioe?aeueieo i?iaeai ?iaae?aeiino? (aeo ai?iaaaeaeaiiy a?ae
05.05.99 ?.), aano?iaioa?ieia?/ieo a?aeae?eaiue iaeanieo oa ?yaeo
i?nueeeo e?ea?aiue Aei?i?iiao?ianueei?, *a?i?aaoeueei?, Eoaainueei?,
?aaii-O?aie?anueei? oa ?ioeo iaeanoae Oe?a?ie (aeoe ai?iaaaeaeaiiy
iaaeathoueny), a oaeiae o iaa/aeueiee i?ioean (i?ia?aie eaeoe?e ?
i?aeoe/ieo caiyoue) oeeee?a caaaeueiiai oa oaiaoe/iiai oaeineiiaeaiiy
e?ea??a ii aano?iaioa?ieia?? eaoaae?e aano?iaioa?ieia?? oa ee?i?/ii?
ae??oieia?? oaeoeueoaoo oaeineiiaeaiiy e?ea??a Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (aeo ai?iaaaeaeaiiy a?ae 28.04.99 ?.).
Aeei?enoiaothoueny i?e i?aeaeuaii? eaae?o?eaoe?? e?ea??a, ye?
i?ioiaeyoue i?aeaioiaeo ia ?iai/iio i?noe? a Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? aano?iaioa?ieia??. On? oe? caoiaee
ni?eythoue cia/iiio i?aeaeuaiith aoaeoeaiino? e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o, cieaeaiith iieaciee?a
iai?aoeacaeaoiino? oa ?iaae?aeiino? a?ae oeueiai caoai?thaaiiy,
iie?auaiith yeino? aeeooy eiioeiaaioo oyaeeeo aano?iaioa?ieia?/ieo
oai?eo.

Iniaenoee aianie caeiaoaa/a. I?aaenoaaeai? a ?iaio? iaoa??aee
yaeythoueny iniaenoei aeeaaeii aaoi?a o ?ic?iaethaaio i?iaeaio.
Naiino?eii aeeiiai?: iaoaioii-?ioi?iaoe?eiee iiooe, iaeyae e?oa?aoo?e,
aecia/aiiy iai?yie?a aeine?aeaeaiiy, iaa?? oa ia?iaea oaeoe/iiai
iaoa??aeo o ee?i?oe? oa aenia?eiaio?, ?ic?iaea iiaeo ?ioi?iaoeaieo
iaoiae?a ae?aaiinoeee (aecia/aiiy ia’?io e?iaiao?aoe, oeeoieia?/ia
ae?aaiinoeea ianiaoeeo?/iiai ae?aceiaiai eie?oo). Noai?aia oi?o?eiaaia
ee?i?ei-noaoenoe/ia eeaneo?eaoe?y ianiaoeeo?/iiai ae?aceiaiai eie?oo.
?ic?iaeai? oa ee?i?/ii aei?iaoaai? iia? iaoiaee e?eoaaiiy oai?eo ia
ianiaoeeo?/iee ae?aceiaee eie?o c aeei?enoaiiyi nieai?io,
aioa?ini?aoe??, iaioeaeieo i?aia?ao?a, i?eioeeiiai iiaee iaoiae
?ioiiei?aeoe?? – aooie?ioie?iioa?ai?y. I?iaaaeaiee aiae?c, noaoenoe/ia
ia?iaea ?acoeueoao?a ee?i?/iiai ? aenia?eiaioaeueiiai aeine?aeaeaiiy,
oai?aoe/ia ocaaaeueiaiiy io?eiaieo ?acoeueoao?a, noai?aia iiaa
eiioeaioe?y iaoiaaiaco ianiaoeeo?/iiai ae?aceiaiai eie?oo. Cae?eniaia
i?aeoe/ia canoinoaaiiy iaaieo iieiaeaiue, iiaoaeiaa ia ?o iniia?
a?aeiia?aeieo aeniiae?a oa ?aeiiaiaeaoe?e, i?aeaioiaea ?oeiieno
aeena?oaoe??, a oaeiae naiino?eii iioae?eiaai? oa aeeeaaeai? aaoi?ii ia
eiia?anao, nai?ia?ao, eiioa?aioe?yo, neiiiceoiao niaoe?ae?no?a iniiai?
?acoeueoaoe aeine?aeaeaiue. O noi?nieo ioae?eaoe?yo oa aeiaoiaeao 90 %
?aeae oa 70 % ?ic?iaie iaeaaeeoue aaoi?o.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai?,
iaaiai?ai? ? noaaeai? ia ? Oe?a?inueeiio eiia?an? aano?iaioa?ieia?a
(i.Aei?i?iiao?ianuee, 1995), neiiiceoi? “?icaeoie ?aeae aeaaeai?ea
A.O.Aaneeaiea o no/ani?e aano?iaioa?ieia??” (i.Iineaa, 1993),
I?aeia?iaeiiio nai?ia?? “Aeooaeuei? i?iaeaie aano?iaioa?ieia?? oa
aiaeineii??” (i.Euea?a, 1995), ? oa ?? ?in?enueeeo aano?iaioa?ieia?/ieo
oeaeiyo (i.Naieo-Iaoa?ao?a, 1995; i.Iineaa, 1996), ?? Oe?a?inueeiio
oeaei? aano?iaioa?ieia?a (i.Aei?i?iiao?ianuee, 1997), Ieaioi?
Oe?a?inueeiai oiaa?enoaa aa?iioieia?a oa aa??ao??a (i.*a?i?aoe?. 1996),
I?aeia?iaeiiio neiiiceoi? ii caiaeueieo caoai?thaaiiyo oianoi? eeoee
(i.Eoaaii, Oaaeoea??y, 1997), A?ei?onueei-iieuenueei-oe?a?inueeiio
oaeuee-neiiiceoi? “Iia? iai?yiee o ae?aaiinoeoe? oa e?eoaaii? oai?ia
ia/?iee oa oianoi? eeoee” (i.Euea?a, 1997), ?anioae?eainuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? c aano?iaioa?ieia?? (i.Oa?e?a, 1998),
XIVc’?cae? oa?aiaao?a Oe?a?ie (i.Ee?a, 1998), I?aeia?iaeiiio
Oaeuee-neiiiceoi? “Iia? aniaeoe a aaiaoieia?? oa aano?iaioa?ieia??”
(i.Oa?e?n?, A?oc?y, 1998), ia can?aeaii? A/aii? ?aaee Oe?a?inueeiai IAe?
aano?iaioa?ieia?? (1999).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 76 ?ia?o, c ieo 16
– aac ni?aaaoi??a, o oiio /ene? 1 iiiia?ao?y, 2 – neeaaeia? /anoeie
iiiia?ao?e, 5 – a?ioo?, 13 noaoae o oaoiaeo aeo?iaeao, 17 – o oaoiaiio
ca??ieeo c i?iaeai aano?iaioa?ieia??, 38 – o ?ioeo aeaeaiiyo oa oac
aeiiia?aeae ia c’?caeao oa eiia?anao, o oiio /ene? 25 – ca ei?aeiiii, 14
aaoi?nueeeo na?aeioeoa oa iaoaio?a o atheaoai? aeiaoiae?a.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 380
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, 4 ?icae?e?a aeanieo aeine?aeaeaiue, ocaaaeueiaiiy,
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaii? e?oa?aoo?e,
yeee i?noeoue 491 aeaea?aei (320 – a?o/eciyieo, 171 – ?iicaiieo
aaoi??a), aeiaeaoe?a. A?ae?ia?ao?/iee iieaae/ee e?oa?aoo?e, ?ethno?aoe??
(61 oaaeeoey ? 20 ?enoie?a) oa aeiaeaoee caeiathoue 104 noi??iee.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Iaoa??aeii aeena?oaoe?? noaee
ee?i?/i?, aenia?eiaioaeuei? oa niaoe?aeuei? eaai?aoi?i? aeine?aeaeaiiy,
aieaoe eieeoi?o iaoe??io?a a?aeae?eaiiy caoai?thaaiue eeoie
Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo aano?iaioa?ieia??.

Iniaeea?noue iaoiaeieia?/iiai i?aeoiaeo a oiio, ui iaoa aeine?aeaeaiiy
aeinyaa?oueny, caaaeyee iine?aeiaiiio ae??oaiith aca?iiiia’ycaieo
caaaeaiue, ii/eiath/e ?c noai?aiiy oi?o?eiaaii? ee?i?ei-noaoenoe/ii?
eeaneo?eaoe?? IAE, ?ic?iaee ia?iaaceaieo iaoiae?a ae?aaiinoeee,
i?eno?i?a aeey ae?aaiinoeee oa e?eoaaiiy, ooi/iaiiy iaoiaaiaco oai?iae o
ee?i?oe? oa ia ?ic?iaeai?e aaeaeaaoi?e iiaeae? a aenia?eiaio?, ?
cae?i/oth/e ai?iaaoe??th iiaeo e?ea?nueeeo cania?a oa ?ic?iaeith
aoaeoeaieo iaoiae?a e?eoaaiiy ? i?io?eaeoeee ?aoeeaeea?a. Oaeee
iaoiaeieia?/iee i?aeo?ae aea? iiaeeea?noue caaeiaai aei cae?i/aiiy
?iaioe ia an?o aoaiao ianeoaiaoaaiiy oai?eo iiceoeaii aieeaaoe ia
?acoeueoaoe e?eoaaiiy, oiaoi iaoeiai-oaoiieia?/iee oeeee caaa?oo?oueny
iaeaeuei aieeaii ia aoaeoeai?noue e?eoaaiiy – noai?aiiyi iiaiai iai?yieo
iaoiaaiaoe/iiai e?eoaaiiy ca aeiiiiiaith aooioieia?/iiai ?ioiii?aia?aoo,
yeee ii?iae?co? ia?o ca ana aioo??oi? ?aaoeyoi?i? ca’ycee o ?ioii?e
nenoai?.

O ?iaio? aeei?enoai? caaaeueiiee?i?/i?, aiaeineii?/i? oa niaoe?aeuei?
a?io?i?/i?, ?ioiieia?/i?, i?e?ia?ieia?/i?, a?noieia?/i?,
?ioiia?noio?i?/i?, iaoio?c?ieia?/i?, ?aae?i?ioiieia?/i?, noaoenoe/i?
iaoiaee aeine?aeaeaiiy, aieaooaaiiy iaoe??io?a. Aeey ooi/iaiiy
iniaeeainoae ?aii?o aoai?a iaoiaaiaco oai?iae ? aca?iia?aeiioaiiy i?ae
iniiaieie eaieaie iaoiaaiaco ia aeiee?i?/iiio oa ee?i?/iiio aoaiao
aeeiiaii 5 na??e, 375 o?ii?/ieo aenia?eiaio?a ia 8 aacii?iaeieo niaaeao,
o oiio /ene? ia 4 niaaeao ?c iiaeaeueiaaiei ae?aceiaei eie?oii.
?aaeoeai?noue ia?aneiiaoe/ii? oa neiiaoe/ii? eaiie aaaaoaoeaii? ia?aiai?
nenoaie ioe?ithaaee ?inoe?ii-i?i?aeiei oanoii. Iaaeeei-a?ieia?/io
iiaeaeue AE noai?thaaee caaaeyee o?eaae?e aeanoaa?e?caoe?? ?aaoeyoi?ieo
iaoai?ci?a oe??? nenoaie, aeoeaaoe?? ai?iiiaeueiiai aia?aoo
oeoieiai-eeoeiaiai o?aeoo iaioaaano?eiii oa ea?aaoie?iii c ianooiiei
iioeiaeaeaiiyi neeciai? iaieiiee i?yii? eeoee ioeoiaith eeneioith
(aeeiiaaaoeue eaiae.a?ie.iaoe A.?.?oaeaiei).

Ee?i?/io /anoeio ?iaioe neeaa aiae?c iniaeeainoae ee?i?/iiai ia?aa?ao
IAE o 433 oai?eo, ye? noaoe?iia?ii e?eoaaeeny o a?aeae?eaii?
caoai?thaaiue eeoie Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo
aano?iaioa?ieia?? c 1989 ii 1999 ??.

92,5 % iaoe??io?a aoee a?eii a?ae 21 aei 60 ?ie?a, ii??aio iaio noaoae,
c o?eaae?noth oai?iae a?ae 1 aei 10 ?ie?a. C eaaeei ia?aa?aii IAE aoei
5,5 %, na?aaeiuei? aaaeeino? – 70,9 %, oyaeeei – 23,6 %. O an?o
caoai?thaaiiy iaei o?ii?/io ?aoeeaeeaoth/o oi?io. Eiio?ieueio a?oio
neeaee 69 caei?iaeo in?a (aeiii?e e?ia?) a?eii a?ae 18 aei 50 ?ie?a, a
oaeiae oai?? ia o?ii?/iee iaae?aceiaee eie?o (106), o?ii?/iee
aioa?ieie?o (10) oa oai?? ia IAE, ye? io?eioaaee aaceniee eiiieaen
e?eoaaiiy (a?oie ii??aiyiiy).

Ae?aaiic IAE anoaiiaethaaee ia iniia? ee?i?ei-aiaiianoe/ieo aeaieo,
aa?eo?eaoe?y i?iaiaeeeany aiaeineii?/ii c a?iin??th oa oeeoieia?/iei
aeine?aeaeaiiyi iace?a-a?aeaeoe?a neeciai? iaieiiee oianoi? eeoee.

? a iniiai?e, ? a a?oiao ii??aiyiiy oai?? ia IAE iaee oeiiao
ee?i?ei-aiaeineii?/io ea?oeio caoai?thaaiiy. Aaaee?noue ee?i?/ii? oi?ie
caoai?thaaiiy aecia/aeany ca ia’?eoeaieie e?eoa??yie ?ic?iaeaii? iaie
oi?o?eiaaii? ee?i?ei-noaoenoe/ii? eeaneo?eaoe?? caoai?thaaiiy.
Iae/ano?oa iaoieia?/iee i?ioean eieae?coaaany o aeenoaeuei?e ae?eyioe?
oianoi? eeoee (58,9 %). Oneeaaeiaiiyie oai?iae aoee inaaaeiiie?iic (38,1
%), no?eeoo?a eeoee (6,9 %), i?ioocia eeoeiaa e?iaioa/a (6,0 %), ?ae
(3,0 %). Aeena?ic eeoa/ieea aoa o a?eueoino? oai?eo (91,0 %) 2 ? 3
nooiai?a. O ia?eoa??ei?e e?ia? no/anieie a?io?i?/ieie iaoiaeaie
aeine?aeaeoaaee ai?no a?noai?io, na?ioii?io, aoeaoeeoie?io,
aoeaoeeoie?ianoa?ace, aae?aiae?io, ii?aae?aiae?io, oea?oeiieaci?io,
na?iioei?ae?a, i?iaeoeo?a ?icuaieaiiy o?a?eiiaaio, ?IE, AeIE, iieaeoe
na?aaeiuei? iane, aeoeai?noue eaoaineio Ae oa aioeieneaeaioio
aeoeai?noue, ?aae?i?ioiieia?/iei aiae?cii – aano?eio, ?inoe?io,
N-iaioeaeo, iaoaieaoae?io, o?eineio, ei?oecieo, IgE; o na/? –
5-iene?iaeieioeoiao eeneioo. ?ioiieia?/i? aeine?aeaeaiiy aeeth/aee
e?euee?nio ioe?ieo O- ? A-e?ioioeeo?a, oaeia?io ? noi?ani?io
noaiiioeyoe?? O-e?ioioeeo?a, i?iaeoeoe?th IL-1 ? IL-2, Oe?E, INO oano,
IgA, IgM, IgG ca noaiaea?oieie ? oi?o?eiaaieie iaoiaeeeaie, a oaeiae
niaoeeo?/i? ee?oeii? ?aaeoe?? uiaei ?aoeaioe?? ?inoe?io, iaioaaano?eio,
a?noai?io, ei?oecieo, naiaeinoaoeio, ?AA, IgE o iaoiaeeoe? ?ioiiiai
?icaoeiooai?aiiy, aooiaioeo?ea aei ie?aieo no?oeoo? NI OE – ?aaeoe??th
iai?yii? ?ioiioethi?anoeaioe??. I?e?iaiee iaecaae oianoi? eeoee aea/aee
iaoiaeii can?ao aeanyoee?aoieo ?icaaaeaiue oaeae?e ia iaa?? aeaeoeaieo ?
aeeoa?aioe?aeueii-ae?aaiinoe/ieo iiaeeaieo na?aaeiaeu aeey aeae?eaiiy
i?aaenoaaiee?a aa?iaii? ? aiaa?iaii? i?e?ioei?e c aecia/aiiyi aeaeiaiai
? e?euee?niiai neeaaeo. ?aeaioeo?eaoe?th aeae?eaieo i?e?ii?aai?ci?a aaee
ca ii?oieia?/ieie, eoeueoo?aeueieie oa a?io?i?/ieie aeanoeainoyie.
Aeei?enoaia aia?aoo?a: o?a?iaano?iaeoiaeaiineii “Olympus GIF-3”,
?aeoi?iiaiineii ?a-AN-3 oa ?a-AN-5, eieiiio?a?ineii Fujinon, na?oeiaee
i?e?ineii IA?-6, aeaeo?iiiee i?e?ineii I-125, ethi?ianoeaioiee i?e?ineii
ETHIAI E-2, oeueo?ai?e?ioii OIOI-6, ?aae?i?ioiieia?/ia onoaiiaea
“Aaia-1”, -e?/eeueiee oa aei??thaaeueia aia?aoo?a: oioiaeaeo?ieiei?eiao?
EOE, ?iiii?? oi?aa?naeueiee YA-74, niaeo?ioioiiao? NO-46 oa
niaeo?ioethi?eiao? Hitachi MPF-4, aaae aiae?oe/i? aeaeo?e/i? AAeA-200 I
? oi?c?iii? AO-500, ae?? 2 eeano, ye? aoee noaiaea?oeciaai? ? i?ioiaeeee
ieaiiaee iao?ieia?/iee eiio?ieue.

Noaoenoe/iee aiae?c io?eiaii? ?ioi?iaoe?? aeeiiaii ca aeiiiiiaith
?ioaa?iaaiiai iaeaoo i?ia?ai Microsoft Word 3,0 ia ia?niiaeueiiio
eiii’thoa?? ?AI ?N/AO 486 i?ae oi?aae?iiyi iia?aoe?eii? nenoaie MS DOS
6.22 ? iaieiiee Windows 3.1 ca aeiiiiiaith i?eeeaaeieo i?ia?ai
aa??aoe?eii? noaoenoeee Stadia 4.0 ? Statgrapher 1.2. A??ia?aei?noue
?acoeueoao?a ioe?ithaaee ca t-e?eoa???i No’thaeaioa, a i?e aea/aii? ci?i
?ioiiiai noaoono – ? ca aaee/eiith oaeoi?iiai iaaaioaaeaiiy F.

Iniiai? ?acoeueoaoe aeine?aeaeaiiy. Ia ia?oiio iai?yieo ?iaioe noai?aiiy
oaoiieia?/ii? iiaeeeaino? aeeiiaiiy iniiaii? iaoe ee?i?/ieo
aeine?aeaeaiue ?ic?iaeai?: oi?o?eiaaia ee?i?ei-noaoenoe/ia eeaneo?eaoe?y
IAE ca aeiiiiiaith ?ioi?iaoeaii-i?ia?aiieo oaoiieia?e ? 3 ae?aaiinoe/i?
iaoiaee aecia/aiiy ia’?io e?iaiao?aoe ?c oeoieiai-eeoeiaiai o?aeoo (A.n.
? 1127928 A, ? 1255923, ? 1397835 N?N?), iaoiae oeeoieia?/ii?
ae?aaiinoeee IAE, i?eno??e aeey ae?aaiinoeee (A.n. ? 1635960), niin?a
aeine?aeaeaiiy eeoee (A.n. ? 1521489), i?eno?i? aeey e?eoaaiiy oianoi?
eeoee (A.n. ? 1699470, Iao.Oe?a?ie ? 1512 N1, ? 5634 N1, ? 20803 A, ?
24695 A, ? 17683 A, ? 1817699 A3). Caaaeyee eaai?aoi?iei oa ee?i?/iei
aeine?aeaeaiiyi anoaiiaeaia i?aeoe/ia cia/ou?noue oa aoaeoeai?noue
noai?aieo iiaeo iaoiae?a ae?aaiinoeee. ?ic?iaeai? iaoiaee ae?aaiinoeee
o?ii?/ii? e?iaioa/? c oeoieiai-eeoeiaiai o?aeoo oa oeeoieia?/ii?
ae?aaiinoeee aeicaieythoue i?aeaeueoe oi/i?noue ?ici?ciaaaiiy IAE,
aecia/eoe nooi?iue oyaeeino? caoai?thaaiiy, aecia/eoe oaco iaoieia?/iiai
i?ioeano, eiai iniaeeaino?, aeeoa?aioe?eiaaii aea?aoe iaiao?aeiee
e?eoaaeueiee eiiieaen, ia?iaaceaii eiio?iethaaoe a aeeiai?oe?
aoaeoeai?noue i?iaaaeaiiai e?eoaaiiy, aecia/eoe o?eaae?noue eiai,
nai?/anii ?iaeea?aeoaeueii ei?aeooaaoe i?aea?? e?eoaaeueieo caoiae?a
uiaei ?ioaineo?eaoe??, o oiio /ene? ? o??o?a?/ieo, i?iaiicoaaoe
oneeaaeiaiiy aeey ?o nai?/aniiai onoiaiiy.

Ae?oaei iai?yieii ?iaioe aoei ee?i?ei-aenia?eiaioaeueia ooi/iaiiy
iniiaieo eaiie iaoiaaiaco IAE oa ?o aca?iia?aeiioaiiy. Anoaiiaeaii, ui
i?e IAE aeieea? cia/iee aeenaaeain i?ae iniiaieie eaieaie aaaaoaoeaii?
?aaoeyoe?? ooieoe?e i?aai?a o?aaeaiiy, yeee noino?oueny iai?io iecee
iae?iiaae?aoi??a, AA? ? ?o ni?aa?aeiioaiiy. Aeyaeai? ci?ie na?ae/aoue
i?i ia?aaaaeaiiy ia ?aii?o aoaiao ?icaeoeo i?e IAE iai?oaeaiiy
ia?aneiiaoe/ii? eaiee ? aeai?an?? aoii?aeueii? oa iaae?aoi?ii? eaiie
neiiaoe/iiai a?aeae?eo AIN, a naia aae?aia?a?/ieo oa na?ioii?ia?a?/ieo
iaoai?ci?a ?aaoeyoe??. E??i oiai, cia/ii i?aeaeuai? (o 1,7-13 ?ac?a)
??ai? a?eueoino? aea/aieo iieaciee?a iaioeaeii? ?aaoeyoe?? (A, N-I), AA?
(?, E, AA, IgE, ?AA, I?O, AeIE), nooi?iue ci?i yeeo /?oei ei?aeth? c?
nooiaiai oyaeeino? ia?aa?ao caoai?thaaiiy, na?ae/aoue, c iaeiiai aieo,
i?i ii?ooaiiy i?ioean?a ?aaoeyoe?? aiiainoaco i?aai?cio i?e IAE ia on?o
aea/aieo ?aaoeyoi?ieo ??aiyo – ia eeoa ia?aiaiio, a e aiaeie?eiiiio ?
?ioiiiio, a c ?ioiai – i?i oienai?th, ii?ooaiiy ooieoe?iiaeueiiai noaio
aaaaoueio nenoai i?aai?cio, c ianooiiei aeniaaeaiiyi
aaeaioaoe?eii-eiiiainaoi?ieo cae?aiinoae ?aaoeyoi?ieo nenoai c
iiaeeea?noth iaaaeaeaaoieo oa ia?aaeienaeueieo ?aaeoe?e.

Aecia/aiiyi eiioeaio?aoe?? INI o ne?iaaooe? e?ia? oai?eo anoaiiaeaii, ui
i?e IAE oeae iieaciee ia a?aeia?aaea? nooi?iue aiaeioieneeico, yeee
cia/iee ? iaoiiaeth? ii?ooaiiy ?ioi?iaoe?eiiai iai?io ? ni?ey?
?iceaaiaeaeaiith nenoaie ?aaoeyoe??, aea, a??ia?aeii, ?ioieneeaoe?y
iia’ycaia ia c iaaeoiaeaeaiiyi ie?aiiaioeae?a aei e?ia’yiiai ?onea, a
aeacaieo aeua AA?, ui iio?aao? i?iaaaeaiiy ?ioaineaieo
aeac?ioieneeaoe?eieo caoiae?a.

Cieaeaiiy ??aiy ?IE, i?aeaeuaiiy AeIE ?acii c aenieei ??aiai I?O oa
ei?oecieo (E) na?ae/aoue i?i ia?aaaaeaiiy eaoaaie?/ieo, caiaeueieo
i?ioean?a o i?aai?ci? ii?yae ?c cia/iei ii?ooaiiyi i?ioean?a
?aaaia?aoe??, i?i o/anoue a?iio?ca?ii-iaaeie?eiai? nenoaie, yea i?e
oyaee?e oi?i? aeniaaeo?oueny ? iio?aao? ei?oeeinoa?i?aeii? oa?ai?? ye
cai?nii?.

Aea/aiiy iniiaieo iieaciee?a nenoaiiiai ?ioi?oaoo iieacaei, ui ?ioiiee
noaoon i?e IAE o a?eueoino? oai?eo oa?aeoa?eco?oueny O-e?ioiiai??th,
?iaa?n??th ?aaoeyoi?ieo noaiiioeyoe?e O-e?ioioeeo?a, aeoeaaoe??th
aoii?aeueii? eaiee ?ioi?oaoo oa oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a,
ae?aaeai?noue yeeo caeaaeeoue a?ae aaaeeino? iaoieia?/iiai i?ioeano.
E??i oiai, ?ioii? ii?ooaiiy a?ae??ciythoueny ?iaeea?aeoaeueiith
aa??aaaeuei?noth. Iniiaiith iciaeith a?aeoeeaiue ?ioiiiai noaoono aoee
ii?ooaiiy eiiia?aoe?? i?ae iniiaieie eiiiiiaioaie ?ioiii? nenoaie a
?ioii?e a?aeiia?ae?, ye? ca?oiiaai? o 3 oeie, iaeoyae/ee c yeeo
oa?aeoa?eco?oueny ?ioiiaeai?an??th (O- oa A-e?ioiiai??th). Aea/aiiyi
aioo??oiuei? i?aai?caoe?? nenoaiiiai ?ioi?oaoo ca aeiiiiiaith oaeoi?iiai
aiae?co anoaiiaeaii, ui o caei?iaeo ethaeae eiiiiiaioe ?ioiii? nenoaie
ia’?aeiai? ca ???a?o?/ii-ooieoe?iiaeueiith cia/ou?noth o aeiee, ye? ?
a?oiaie aiaeia?/ii ci?ithaaieo iieaciee?a, ?icoaoiaaieo o ii?yaeeo
ciaioaiiy aeeaaeo a caaaeueio aeenia?n?th, oeaio?aeueiei c yeeo ? noai?i
cae??ieai? aiiainoaoe/i? iaoai?cie, ye? ?aaoeththoue ?ici??e ioeo
eaeeioeeo?a ? ni?aa?aeiioaiiy a iueiio iiioeyoe?e, noaiiioeyoe?e oa ?o
ooieoe?iiaeueio aeoeai?noue, ui ? caaacia/o? aaeaeaaoi?noue ?ioiii?
a?aeiia?ae? ia aoaeue-yeee iaoiaaiiee /eiiee. I?e IAE oa?aeoa?
eiiia?aoeaieo a?aeiioaiue i?ae ?ioiieiiiaoaioieie aeaiaioaie nenoaie
ii?ooo?oueny. Oae, i?e na?aaeiueiaaaee?e oi?i? aeieeee ?ic?eae
ooieoe?iiaeueieo ca’yce?a i?ae ie?aieie eaieaie c oi?ioaaiiyi iiaiai
??aiy aca?iia?aeiioaiue, iaoiiaeaieo aeoeaaoe??th aoii?aeueii? eaiee
?ioi?oaoo, ianiaoeeo?/ii? aeoeaiino? oaaioeeo?a ? ?aaoeyoi?ii?
O-noi?ani?ii? eaiee ?ioi?oaoo. Io?eiai? aeai? na?ae/aoue i?i
ooieoe?iiaeueio iiaiioe?ii?noue iaeo?io?e?a o oai?eo c eaaeei oa
na?aaeiuei? oyaeeino? ia?aa?aii IAE, ye? aaeaeaaoii ?aaaothoue ia
aeoeaaoe?th aoii?aeueiiai ?ioi?oaoo i?aeneeaiiyi oaaioeeoico, ui
aeicaiey? aaaaeaoe i?aeaeuaiiy ??aiy Oe?E o ne?iaaooe? e?ia?
?acoeueoaoii i?aeneeaii? i?iaeoeoe?? ?ioiiaeiaoe?i?a oa aioeaai?a, a ia
ii?ooaiiyi iaoai?ci?a ae?i?iaoe??.

?c ca?eueoaiiyi aaaeeino? oai?iae aaeaeaaoi?noue i?aeaeuaiiy
oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a, nooiaiy aeoeaaoe?? aoii?aeueii?
eaiee ?ioi?oaoo (A-e?ioioeeo?a, Ig, Oe?E) ii?ooo?oueny, aeieea?
oaiaeaioe?y aei cieaeaiiy ?aca?aieo iiaeeeainoae oaaioeeoico.

I?e oyaee?e oi?i? IAE aieiaiith a?aei?iith ? cia/ia ciaioaiiy e?eueeino?
ei?aeyoeaieo ca’yce?a i?ae niaeo?ii iniiaieo iiioeyoe?e
?ioiieiiiaoaioieo ee?oei, ye? neeaeeny o aieiaiee aeie, oa aoii?aeueiei
?ioi?oaoii, oaaioeeoa?iith aeoeai?noth iaeo?io?e?a ? ooieoe?iiaeueii
aeoeaieie noaiiioeyoe?yie iaeo?io?e?a, ui na?ae/eoue i?i cieaeaiiy
eiiiainaoi?ieo iiaeeeainoae ?ioiieo iaoai?ci?a, ?ic?ea ?nioth/eo
ca’yce?a, ye? o iia?e, neeaaei?e ?ioi?iaoe?ei?e neooaoe?? iani?iiiaei?
a?aeiiaeoeny aac iiooiaoo cciai?. Eiaeia eaiea ii/eia? ?nioaaoe
aaoiiiiii, ui aaaea aei ooai?aiiy oeaiiai eiea c iaaeaiiyi i?ei?eoaoo o
ca’yceao aeoeaiaaiei noaiiioeyoe?yi Oo, On oa e?ioioeeoai, ye? iathoue
ia iiaa?oiaa?e iaia?ai? ?aoeaioi?e aeey AOAN, na?aae yeeo iaioeaee,
ai?iiie, oeeoie?ie, oiaoi aeieeathoue ?io? ??ai? ?aaoeyoi?ieo ca’yce?a.
I?aeaeuaiiy ?aoeaioi?ii? aeni?an?? naiaeinoaoeio (NaN) oa ei?oecieo i?e
oyaee?e oi?i? IAE iaa?oioiaothoue iiaeeea?noue cia/ii? e?eoaaeueii? ae??
NaN oa ei?oeeinoa?i?aeieo ai?iiiaeueieo i?aia?ao?a. O oeeo oiiaao
ia?niaeoeaiei ie aaaaea?ii canoinoaaiiy oeeoie?i?a aeey a?aeiiaeaiiy
?aaoeyoi?ieo ca’yce?a, anoaiiaeaiiy yeeo iiaeia ?iaeoeoaaoe
?ioiiiaae?aoi?aie, ae?iaeaieie ooieoe?iiaeueii caeaoieie iiiiioeeaa?aie
in vitro c ianooiiei oaaaeaiiyi o i?aai?ci. Anoaiiaeaii, ui o oai?eo ia
IAE c?inoa? ?ieue ?aaoeyoi?ieo oaeoi??a – oeeoie?i?a, ye e?eoaaeueieo
cania?a, ye? iiaeooue a?aeiiaeoe ii?ooai? eiiia?aoeai? ca’ycee i?ae O-
oa A-ee?oeiaie, oa ona?aaeei? oeeo nenoai, caaaeyee iie?auaiith
?ioi?iaoe?eiiai iai?io i?ae ??cieie ee?oeiaie (ia?aiaeie, aeeoocieie
aiaeie?eiieie oa ?ioiieiiiaoaioieie), ui, ye noaei a?aeiii, cia/ii
aoaeoeai?oa ? aeioe?euei?oa, i?ae ei?aeoe?y ia aoaeoi?iiio ??ai?.

Aeine?aeaeaiiyi ii?oieia?/ieo ci?i NI eeoee anoaiiaeaia iayai?noue
aeeoociiai o?ii?/iiai ianiaoeeo?/iiai caiaeaiiy c ?ioiiei eiiiiiaioii
i?ioyaii onueiai o?aaiiai eaiaeo, iaea?eueo ae?aaeaiiai o oiano?e
eeooe?, aei oiai ae o iieiaei? aeiaaee?a – c ao?io?/ieie ci?iaie o
caeicenoiio aia?ao?.

Aeyaeaia iaeiaeiaa aaoa?iaaii?noue e?euee?niiai ia?a?iciiae?eo
aiaeie?eiioeeo?a o neecia?e iaieiioe? oiiei? ? oianoi? eeoie: ia
ae?eyieao caiaeaiiy, o a?ioeyo aeeaieeo a?ic?e oa ae?acie c aeoeaiith
?aaaia?aoe??th e?euee?noue aiaeie?eiioeeo?a ca?eueoo?oueny c
ia?aeaeueiei ciaioaiiyi e?eueeino? aieaeiiiae?aieo ee?oei ? ?icaeoeii
aooi?ioiieo i?ioean?a (iiyaith aooiaioeo?e aei aieaeiiiae?aieo ee?oei,
aiaeii?c?aeueieo ? ?ioeo no?oeoo?ieo aeaiaio?a NI). A i?ioeeaaei?noue
oe?e iia?e?caoe?ei?e a?aeiia?ae? aeeoocii? aiaeie?eiii? nenoaie ia
iioeiaeaeaiiy eeoee o ciiao iie?iiiiae?aieo ?ic?inoaiue, ia ae?eyieao
oi?ioaaiiy e?eio-aanoean?a oa o iaiioeiaeaeaieo ae?eyieao neeciai?
iaieiiee e?euee?noue aiaeie?eiieo ee?oei ciaioeeany. Oey caeiiii??i?noue
na?ae/eoue i?i aeoeaio o/anoue aiaeie?eiioeeo?a, oiaoi on??? aeeoocii?
aiaeie?eiii? nenoaie o iaoiaaiac? oa naiiaaiac? i?e IAE, i?i ?aaeoe??
oe??? nenoaie ye ?aeeiiai oe?e?niiai i?aaio, aeaiaioe yeiai
?iciianthaeaeai? ii on?e NI eeoee.

Aeyaeaia i?e a?noio?i?/iiio aeine?aeaeaii? o i’ycia?e oeaiei? oa no?ii?
NI OE ?ic?inoaiiy ?io?aio?aeueii? ia?aiai? oeaieie c i?iaeoeoe??th A?Io,
yeee ciaoiaeeany ia o?eueee a aiaeie?eiieo ee?oeiao, a?ae?inoeao
ia?aiaeo ee?oei, a ua e o oeeoiieaci? i?eciaoe/ieo ai?oae?ioeeo?a
eeoeiaeo e?eio, na?ae/eoue i?i aeiaeaoeiaee neioac eiai oa oeeoie?i?a
(oaeoi?o c?inoaiiy ia?aiaeo ee?oei) i?e IAE. Nii/aoeo, iiaeeeai, oea
yaeua aeeiio? eiiiainaoi?io i?n?th, a iaaeae? a ?acoeueoao? ii?ooaiiy
?ioi?iaoe?eiiai iai?io i?ae ee?oeiaie oa ?aaoeyoi?ieie nenoaiaie
(ia?aiaith, ai?iiiaeueiith ? ?ioiiith) ia?aoai?th?oueny o iiaooi?e
iaoiaaiiee iio?e, yeee iaoiiaeth? onth aaio ?iceaae?a o oai?eo ia IAE
(a?ia?nae?aoi?ia ae?a?ay, ?acenoaioia aei e?eoaaiiy, aaaaoi-noaeeii?
?aaeoe??, ?ic?ea eiioaeo?a i?ae ai?oae?ioeeoaie, ii?ooaiiy o?i?cio
caoeniiai neeco ? o.?i.).

Aecia/aii, ui i?e IAE aeena?ic ? aiaeii/an ? iane?aeeii ii?ooaiiy
caaaeueiiai oa eieaeueiiai ?ioi?oaoo neeciai? iaieiiee oianoi? eeoee, ?
iaei??th ?c i?ia?aeieo eaiie iaoiaaiaco. Anoaiiaeaii, ui aeey IAE
oa?aeoa?i? iie?eiiiiiaioi? aeena?ice OE, ye? noinothoueny ye iae?aaoii?,
oae ? oaeoeueoaoeaii? i?e?ioei?e, nooi?iue ae?aaeaiino? yeeo /?oei
ei?aeth? c? nooiaiai oyaeeino? ia?aa?ao oai?iae.

Noai?aia aaeaeaaoia iaaeeei-a?ieia?/ia iiaeaeue ae?aceiaiai eie?oo
aeicaieeea niaoe?aeueieie aeine?aeaeaiiyie i?aeoaa?aeeoe ae??a?noue
aecia/aieo iniiaieo eaiie iaoiaaiaco IAE, oiaaieoeny o oaciaino?
i?ioean?a, ye? a?aeaoaathoueny ? a e?ioe? e?ioe?a i?ecaiaeyoue aei
ooieoe?iiaeueiiai aeniaaeaiiy aeeoocii? aiaeie?eiii? nenoaie, a c iath
oaeiae i?ioean?a aaeaioaoe??, eiiiainaoe?? ? ?aaoeyoe?? a oe?eiio, ui
ae?aaea?oueny oaiiiaiii “a?aeiiae ?aaoeyoe??”. Ai?iaaoe?y a aenia?eiaio?
iiaiai neioaoe/iiai i?ieiiaiaaiiai iaioeaeiiai i?aia?aoo naiaeinoaoeio
aeyaeea e??i iiceoeaiiai aieeao eiai, iaaaoeai? noi?iie, ui caiia?aei
oneeaaeiaiiyi i?e aeei?enoaii? i?aia?aoo o ee?i?oe?.

Oaeei /eiii, ee?i?ei-aenia?eiaioaeueia aea/aiiy noaio ?
aca?iia?aeiioaiiy ia?aiai?, ?ioiii? oa aeeoocii? aiaeie?eiii? nenoai i?e
IAE ye ?ioiii-caiaeueii-aeano?oeoeaiiio caoai?thaaii? aeicaieeei iai
aeae?eeoe eeth/iaith eaieith o eiai iaoiaaiac? aeanoaa?e?caoe?th
eiiia?aoeaieo ca’yce?a o an?o oeeo ?aaoeyoi?ieo nenoaiao, icia/aieo ye
?aeeia ?aaoeyoi?ia e?eueoea: ii?ooo?oueny ia?eoao i?ae ieie oa i?ae
ie?aieie aeieaie ? iaoai?ciaie ona?aaeei? ?o ia oii? oa i?e o/ano?
niaaeei?iii? noeeueiino? aei IAE, aaiaoe/ii iaoiiaeaii? neaaeino?
a?aeiiaethaaeueieo i?ioean?a, ianaiia?aae ?ioiii? nenoaie. Nooo?ao ci?io
ia e?aua iaaeathoue ?ioiiaeoeai? i?aia?aoe, noai?ai? ia iniia?
oeeoie?i?a, aea ? aiie iathoue iia?/i? yaeua. Oiio aeaoaeueii aea/aia
aoaeoeai?noue ianiaoeeo?/ii? ?ioiinoeioeyoe?? i?aeneeaiiy ?ioiii?
a?aeiia?ae? ianeaiei niiniaii ca aeiiiiiaith aeiii?nueeiai
aaiaaeiaoe?io, aeeiaaiieo iaoo?aeueieo oa neioaoe/ieo iaioeaeieo
i?aia?ao?a.

Aeyaeai? o i?ioean? aeine?aeaeaiiy iniaeeaino? iaoiaaiaco IAE ?
?acenoaioiino? ie?aieo eiai iniiaieo eaiie aei e?eoaaeueii? ae??
oiaaieee a iaiao?aeiino? ?ioaineo?eaoe?? e?eoaaiiy oai?eo oeyoii
iine?aeiaiiai canoinoaaiiy aioa?ini?aoe??, aeaceioieneeaoe??,
ianiaoeeo?/ii? ? niaoeeo?/ii? ?ioiinoeioeyoe?? oa iaoo?aeueieo
iaioeaeieo i?aia?ao?a, aieiae?th/eo iaiao?aeiith
iie?ooieoe?iiaeuei?noth aieeao ia i?aai?ci ia oii? i?ioecaiaeueii?,
i?ia?ioe/ii? oa ae??oe/ii? oa?ai??.

E?eoa??yie aaeaeaaoiino? e?eoaaiiy aeei?enoai? ?ic?iaeai? aaoi?ii
iaoiaeeee, aecia/ai? ca ieie ia’?eoeai? iieacieee, a oaeiae iiceoeaia
aeeiai?ea ee?i?/iiai ia?aa?ao oai?iae, aiaeineii?/ii?, oeeoieia?/ii?
ea?oeie o?aaeaiiy NI OE ? oeo aeeiai?/ieo iieaciee?a aiiainoaco, ye?
iaea?eueo ia’?eoeaii ? aeaiiino?aoeaii a?aeia?aaeaee aeoeai?noue ?
aaaee?noue iaoieia?/iiai i?ioeano, /?oei a?aeiiaethaaeeny o i?ioean?
e?eoaaiiy. Ee?i?ei-aiaeineii?/ia ?ai?n?y i?aeoaa?aeaeaia aiaeineii?/ii,
oeeoieia?/ii, ii?iae?caoe??th ee?oeiii? ? aoii?aeueii? eaiie ?ioi?oaoo,
eiai aioo??oiueiai ?aaoeyoi?iiai iaoai?cio, ??aiy o e?ia? AOAN,
a?aeiiaeaiiyi aoa?ico oianoi? eeoee.

C’yniaaii, ui aioa?ini?aoe?y noi?nii c? nieai?iii aeicaiey? i?aeaeueoe
aoaeoeai?noue e?eoaaiiy oai?eo ia IAE, nei?ioeoe oa?i?i noaoe?iia?iiai
e?eoaaiiy ? aeinyaoe caai?iiy ae?acie oa a?ic?e o NI OE i?e iie?auaii?
?ioiiiai noaoono. I?inoioa, aeinooii?noue oa aoaeoeai?noue ?ic?iaeaiiai
niiniao (oi?ioee aoaeo io?eiaii o 45,0% oai?eo, caaeia?eueiee – o
55,0%), ia yeee io?eiaii iaoaio Oe?a?ie ? 9037, aea? iiaeeea?noue
?aeiiaiaeoaaoe eiai aeey oe?ieiai canoinoaaiiy a aano?iaioa?ieia?/i?e
i?aeoeoe?, aea a?aenooi?noue iiaiiai a?aeiiaeaiiy ?ioiiiai noaoono oa
iiaeeea?noue aea?a?/ii? ?aaeoe?? ia aeeiaaiiee a?eeiaee i?aia?ao, a
oaeiae a?aenooi?noue caiia?aaiiy aeieeiaiith ?aoeeaeeao niiioeaee aei
iiaeaeueoiai iiooeo a?eueo aoaeoeaiiai niiniao e?eoaaiiy.

Iaea?eueo /?oeee aieea ia iieacieee ?ioi?oaoo o a?oi? iaioeaeieo
i?aia?ao?a cae?enithaaa a?o/eciyiee a?a?nie, ui iiaeia iiynieoe eiai
nii??aeiai?noth c ee?oeiieie iaia?aiaie aia??iiaeueieo oeaiei oa ae??th
noeoiiino? oaeeo niieoe, ye? ? a iaoo?aeueiiio iaioeaeiiio i?aia?ao?.

Iaeiae, iacaaaeath/e ia iaaiee aoaeo e?eoaaeueiiai canoinoaaiiy
i?aia?ao?a, ye? i?noyoue o nai?io neeaae? iaioeaee, aiie oaae iathoue
iaaeie?ee, iia’ycai? c iiaeeea?noth aeeeeeaoe aea?a?/i? ?aaeoe??. I?e
canoinoaaii? oeeo i?aia?ao?a o ??cieo eiia?iaoe?yo ii?aeiaiiy i?ae
niaith (a?a?nie ?acii c aaiaaeiaoe?iii, aeaea?a?i c aaiaaeiaoe?iii aai
aeoiaaa?i c aaiaaeiaoe?iii) anoaiiaeaii, ui ii?aeiaia canoinoaaiiy
cia/ii aoaeoeai?oa ?cieueiaaiiai aeei?enoaiiy, aea ?acii c oei c?inoa?
iaaaciaea aeieeiaiiy iia?/ieo yaeu aea?a?/iiai oeio.

Iaie ?ic?iaeaii niin?a ?iaeoeoi?ii? ?ioiiei?aeoe?? oeyoii io?eiaiiy in
vitro ? oaaaeaiiy oai?iio eiiieaeno oaeoi??a, ye? a?aeiiaeththoue
ii?ooaiee ?aaoeyoi?iee iaoai?ci nenoaie ?ioi?oaoo ? noeioeththoue
ae?iaeaiiy a i?aai?ci? naia oeo, iaiao?aeieo aeey iueiai, iaaeinoaoi?o
eiiiiiaio?a aeanieie ?ioiieiiiaoaioieie ee?oeiaie (Iaoaio Oe?a?ie ?
23831 A 61 E 38/00 a?ae 16.06.98 ?. “Niin?a e?eoaaiiy ianiaoeeo?/iiai
ae?aceiaiai eie?oo”) (?en. 1).

Canoinoaaiiy aooie?ioie?i?a (AEE) o 100 oai?eo ia IAE iieacaei, ui AEEO
ia eeoa onoaa? ?ioiiaeai?an?th, a ua e ii?iae?co? ni?aa?aeiioaiiy
?aaoeyoi?ieo noaiiioeyoe?e O-e?ioioeeo?a: O-oaeia??a ? O-noi?ani??a,
oaaioeeoa?io aeoeai?noue iaeo?io?e?a (oaae. 1).

Oaaeeoey 1 – Aeeiai?ea ?ioiieia?/ieo iieaciee?a o oai?eo ia

IAE i?ae aieeaii aooioeeoie?iioa?ai??

IieacieeeOai?? ia IAE

(n=100)Caei?ia? ethaee (n=35)aei e?eoaaiiyi?ney?E?ioioeeoe,
%31,7+0,78*32,6+0,74*>0,0528,3+1,14a./.
o109/e1,95+0,062,08+0,07*0,0520,8+0,90a./.
o109/e0,51+0,02*0,54+0,03*>0,050,42+0,03NAe4-?OE,
%25,79+0,89*34,84+0,890,0516,3+1,03a./.
o109/e0,36+0,02*0,37+0,02*>0,050,29+0,02IgA
a/e2,53+0,082,73+0,09*0,0514,0+1,59Oe?E
iae.ii.u.7,2+0,407,60+0,43>0,057,3+0,32* – noaoenoe/ii cia/oua (?

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