Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i I.E. Ooieea IIC
Oe?a?ie

Ia i?aaao ?oeiieno

Noao?iiaa Ieaia Aiaoie??aia

OAeE 616.833.24-002

IIA? I?AeOIAeE AeI E?EOAAIIss NIIIAeEEIAAIIIAI

IIIA?AEIAI-E?EAEIAIAI ?AAeEEOE?OO

14. 01.15 — ia?aia? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a-1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I. Ai?ueeiai IIC Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? Iaca?aiei Aaaeei
A?eai?iae/,

Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I. Ai?ueeiai IIC
Oe?a?ie, eaoaae?a

ia?aiaeo oai?ia, caa?aeoaa/ eaoaae?e

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? Aeoaaiei Aaaai
A?eai?iae/,

Oa?e?anueeee iaaee/iee oi?aa?neoao IIC Oe?a?ie, eaoaae?a ia?aiaeo
oai?ia, caa?aeoaa/ eaoaae?e

aeieoi? iaaee/ieo iaoe, i?ioani? Naiinthe ?aai Caoa?iae/,

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i I.E. Ooieea IIC
Oe?a?ie, eaoaae?a iaaee/ii? ?aaa?e?oaoe??, o?c?ioa?ai?? oa eo?i?oieia??,
caa?aeoaa/ eaoaae?e

I?ia?aeia onoaiiaa: Oe?a?inueeee IAe? ee?i?/ii? oa aenia?eiaioaeueii?
iaa?ieia?? oa ineo?ao??? IIC Oe?a?ie, i. Oa?e?a, a?aeae?e iaoieia??
aaaaoaoeaii? ia?aiai? nenoaie

Caoeno a?aeaoaeaoueny “27” o?aaiy 1999 ?. i 11 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.613.01 i?e Ee?anuee?e iaaee/i?e
aeaaeai?? i?neyaeeieiiii? ina?oe ?i I.E.Ooieea

IIC Oe?a?ie: 254112 i. Ee?a, aoe. Aei?iaiaeeoeueea, 9, aoaeeoi??y ?3

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i I.E.Ooieea IIC Oe?a?ie: 254112 i.
Ee?a, aoe. Aei?iaiaeeoeueea, 9

Aaoi?aoa?ao ?ic?neaiee “23” ea?oiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee, e. i. i., aeioeaio
I.?. ?iiaiaiei

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie.

Niiiaeeeiaaiiee iiia?aeiai-e?eaeiaee ?aaeeeoe?o (NIE?), ca aeaieie
??cieo aaoi??a, neeaaea? 60-95% on?o oai?ia ia?eoa?e/ii? ia?aiai?
nenoaie (?.I. Aioiiia,1985, ss.TH. Iiiaeyinueeee, 1989, I.E. AEa?eia,
1994). A Oe?a?i? caoai?thaai?noue ia inoaioiiae?ic o?aaoa cono??/a?oueny
o 144,3 ia 10 oen. ianaeaiiy (I.?.Oaenthe, 1995). Na?aae in?a, caeiyoeo
o aaaee?e i?iieneiaino?, NIE? aeyaey?oueny o 5-10 aeiaaeeao ia 100
i?aoethth/eo ? noi?iaiaeaeo?oueny no?eeith ao?aoith i?aoeacaeaoiino?, ui
i?ecaiaeeoue aei cia/ieo aeiiii?/ieo ao?ao (A.A. Ae?eaioeiia, 1990,
I.Ae. Aiaiiieiaa, 1993).

Aenieee ??aaiue caoai?thaaiino?, iaaeinoaoiy aoaeoeai?noue e?eoaaeueieo
caoiae?a aecia/athoue aeooaeuei?noue oe??? i?iaeaie (A.I. Aanaeianueeee,
1991, A.A. Ei?ae, 1994).

O e?oa?aoo?? aeoeaii aeeneooothoueny ieoaiiy, i?enay/ai? ?ioiiei?aeoe??
o oai?eo ia NIE?, oiio ui aooi?ioii? ?aaeoe??, ui aeieeathoue i?e
a?eaeao i?aeo?aaoeaaeo aeene?a, ? iaeieie c iniiaieo i?e/ei aoi?eiii?
ei??ioeaai? iaoieia??. I?e oeueiio iniaeeaee ?ioa?an aeeeeea?
canoinoaaiiy eaaai?cieo, yeee caeaoiee noeioethaaoe O-noi?ani?e i?e
??cieo aooi?ioiieo noaiao (A.ss Eaoeoaaa, 1990). Iaeiae, ? a?-aeiiino?,
ui na?ae/aoue i?i iaaoaeoeai?noue canoinoaaiiy i?aia?aoo o oaeiai
eiioeiaaioo oai?eo, a oa-eiae aeine?aeaeaiiy, ye? caia?a/othoue aieea
eaaai?cieo ia noi?ani?i? ee?oeie (Samson, 1986, Hokama,
1994).

Aeieacaia ?ieue noaeeiiiai oaeoi?a o ?icaeoeo aeeno?io?/ieo ci?i o
i?aeo?aaoeaaeo aeeneao (TH.?. Aieia/aiei, 1989, A. A.Neoaeue,
1991). Ii?ooaiiy i?e?ioee?eoeyoe?? a o?aaoiaeo naaiaioao i?e NIE?
i?ecaiaeyoue aei aaiicii? aeenoii??, ui ae?aaea?oueny ye aeeeyoaoi?ieie,
oae ? eiino?eeoi?ieie ?aaeoe?yie ?ie?nieo noaeei (I.I.Iaaeiaa, 1992).
Inoaii?i /anii o ??cieo iaaee/ieo aeenoeeie?iao oni?oii canoiniao?oueny
iaoiae iaaaoeaiiai oeneo, i?eeeaaeaiiai ia ieaeith /anoeio o?ea (IOIO)
iaoe?-?ioa. Aieea IOIO aeeeeea? cia/i? c?ooaiiy oeaio?aeueii? oa
ia?eoa?e/ii? aaiiaeeiai?ee ca ?aooiie aeaiiioaaiiy /anoeie
oee?eoethth/i? e?ia? o ?ie?nieo noaeeiao, ?icoaoiaaieo o cii? aieeao
( A.A.Aeaaoy?ueia, 1987). O oie aea /an ie ia cono??ee
aeiaeiiai iia?aeiieaiiy i?i canoinoaaiiy oeueiai iaoiaeo e?eoaaiiy o
oai?eo ia NIE?.

O oa?ai?? aieueiaiai neiae?iio NIE? oe?iei aeei?enoiaothoueny ??ci?
aeaee aeieaae iiaiea?iii, aiaeueaacoth/eie noi?oaie ?
aetheiei?oeeinoa?i?aeaie ( I. I. A?i?a, 1992, A. A. Ai?caeeeia, 1996
). Iaeiae, o e?oa?aoo?? ? eeoa iaeeie/i? iia?aeiieaiiy i?i
aiaeiethiaaeueia canoino aaiiy i?aaei?cieiio i?e aeayeeo caoai?thaaiiyo
ia?aiai? nenoaie (ooaa?eoeueiciee iai?iaiaioeaoae?o, i??e?o,
iae?ieaeea-i?y) ? iaia iia?aeiieaiue i?i aeei?enoaiiy oeueiai iaoiaeo
e?eoaaiiy o oai?eo ia NIE?.

Oi?ioee ee?i?/iee aoaeo i?e e?eoaaii? ??cieo iaa?ieia?/ieo i?iya?a NIE?
iaea?aeaiee ca ?aooiie aeei?enoaiiy iecueei?ioaineaiiai eaca?iiai
ii?ii?iaiiy (I?EI) (?.C.Naiinthe, 1997, N.A.Aai??a, 1997). O oie aea /an
caeeoathoueny aeeneon?eieie ieoaiiy i?i aeice ? noaie, iieacaiiy ?
i?ioeiieacaiiy aei eaca?ioa?ai?? o oai?eo c aeeno?io?/ieie
caoai?thaaiiyie o?aaoa (A.Ae. A?eee, 1993).

Iaae??oai?noue oe?eiai ?yaeo ieoaiue, iiaycaieo c oa?ai??th oai?eo ia
NIE?, niiioeaei ian ooeaoe iia? i?aeoiaee aei e?eoaaiiy oeueiai
caoai?thaaiiy.

Caycie ?iaioe c iaoeiaith i?ia?aiith i?aai?caoe??, aea aeeiiaia
aeena?oaoe?y.

Aeena?oaoe?eia ?iaioa aeeiiaia o a?aeiia?aeiino? c ieaiii iaoeiaeo
aeine?aeaeaiue eaoaae?e ia?aiaeo oai?ia c eo?nii iae?io??o?a?? oa
iaaee/ii? aaiaoeee Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i. I. Ai?ueeiai (iiia? aea?aeaaii? ?a?no?aoe?? 0193V020619 ?E
93.03.05).

Iaoa ? caaea/? aeine?aeaeaiiy.

Iaoa ?iaioe: i?aeaeueoe aoaeoeai?noue e?eoaaiiy oai?eo ia NIE? ca
?aooiie ai?iaaaeaeaiiy eiiieaeniiai aeeoa?aioe?eiaaiiai e?eoaaiiy, ui
aeeth/a? canoinoaaiiy ?ioiiei?aaoth/i? oa?ai?? eaaai?cieii; iaaaoeaiiai
oeneo, i?eeeaaeaiiai ia ieaeith iieiaeio o?ea iaoe??ioa;
aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio ? aae?e-iaiiiaiai eaca?a.

Aeey aeinyaiaiiy iaoe iinoaaeai? oae? caaea/?:

1. Aea/eoe iniaeeaino? ?ioiieia?/ii? ?aaeoeaiino? ? ?ic?iaeoe noaio
?ioiiei?aaoth/i? oa?ai?? o oai?eo ia NIE?.

2. ?ic?iaeoe iaoiaeeeo aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio,
aecia/eoe iieacaiiy ? i?ioeiieacaiiy aei oeueiai niiniao e?eoaaiiy.

3. I?iaanoe ii??aiyeueio ioe?ieo aiaeiethiaaeueiiai oa ai?aeo?aeueiiai
aaaaeaiiy i?aaei?cieiio.

4. ?ic?iaeoe iaoiaeeeo e?eoaaiiy oai?eo c aeei?enoaiiyi iaaaoeaiiai
oeneo, i?eeeaaeaiiai ia ieaeith iieiaeio o?ea iaoe??ioa, aecia/eoe
iieacaiiy ? i?ioeiieacaiiy aei aeaiiai iaoiaeo e?eoaaiiy.

5. ?ic?iaeoe iaoiaeeeo e?eoaaiiy aae?e-iaiiiaei eaca?ii o eiiieaeni?e
oa?ai?? NIE?.

6. ?ic?iaeoe aeai?eoi eiiieaeniiai aeeoa?aioe?eiaaiiai e?eoaaiiy NIE? ?
i?iaanoe eiai ee?i?/io ai?iaaoe?th.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa aea/aia /ooeea?noue e?ioioeeo?a aei eaaai?cieo in vitro o oai?eo
ia NIE? ? aeyaeaii cieaeaiiy e?eueeino? O-noi?ani??a o ieaci? e?ia? o
oai?eo c ei??ioeaaei neiae?iiii NIE?. Aea/aii aieea ?ioiiei?aaoth/i?
oa?ai?? ia ia?aa?a aooi?ioiiiai i?ioeano o oai?eo ia NIE? ? ia iniia?
iaea?aeaieo aeaieo ?ic?iaeai? iioeiaeuei? aeice oa noaie e?eoaaiiy
eaaai?cieii.

?ic?iaeaia i?ea?iaeueia iaoiaeeea aiaeiethiaaeueiiai aaaaeaiiy
i?aaei?cieiio o oai?eo ia NIE?, anoaiiaeai? oaeoi?e, ui aieeaathoue ia
aoaeoeai?noue oeueiai niiniao e?eoaaiiy, aecia/ai? iieacaiiy ?
i?ioeiieacaiiy aei i?ecia/aiiy oeueiai iaoiaeo.

Aia?oa aeei?enoaiee o?c?ioa?aiaaoe/iee iaoiae e?eoaaiiy, ui a?oioo?oueny
ia aieea? iaaaoea-iiai oeneo, i?eeeaaeaiiai ia ieaeith iieiaeio o?ea
iaoe??ioa. I?iaaaeaia ee?i?ei-?ino?oiaioaeueia ioe?iea aoaeoeaiino?
aieeao iaaaoeaiiai oeneo ia ia?eoa?e/io aaiiaeeiai?eo oai?eo ia NIE?.

?ic?iaeaii ? ai?iaaaeaeaii o ee?i?/io i?aeoeeo aeai?eoi e?eoaaiiy, yeee
aea? iiaeeea?noue i?iai-aeeoe aeeoa?aioe?eiaaio oa?ai?th NIE?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

O ?iaio? aeieacaii, ui i?e cieaeaii? e?eueeino? O-noi?ani??a ? iayaiino?
/ooeeaino? e?ioioeeo?a aei eaaai?cieo in vitro o oai?eo ia NIE?
iaiao?aeii i?iaiaeeoe ?ioiiei?aaoth/o oa?ai?th.

?ic?iaeaia iaoiaeeea aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio, yea
aeicaiey? aoaeoeaii eoi??o-aaoe aieueiaee neiae?ii o oai?eo ia NIE?.
Aecia/aia iioeiaeueia e?aoi?noue aaaaeaiiy i?aia?aoa, i?iaaaeaia
ii??aiyeueia ioe?iea aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio oa
ai?aeo?aeueieo aeieaae.

Oai?aoe/ii iaa?oioiaaiee ? ai?iaaaeaeaiee iiaee o?c?ioa?aiaaoe/iee
iaoiae aeey e?eoaaiiy oai?eo c ?aoeaeoi?iei neiae?iiii, ui a?oioo?oueny
ia aeei?enoaii? iaaaoeaiiai oeneo, i?eeea-aeaiiai ia ieaeith iieiaeio
o?ea iaoe??ioa ( IOIO). ?ic?iaeai? iieacaiiy ? i?ioeiieacaiiy, a oaeiae
iaoiaeeea aieeao IOIO.

?ic?iaeaiee aeai?eoi aeeoa?aioe?eiaaiiai e?eoaaiiy NIE?, aeei?enoaiiy
yeiai aeicaieeei i?aeaeueoe aoaeoeai?noue oa?ai??, ui i?iaiaeeeany,
cieceoe /enei ?aoeeaeea?a ? ciaioeoe e?euee?noue oneeaaeiaiue.
Cai?iiiiiaai? noaie ? iaoiaee e?eoaaiiy iiaeooue aooe aeei?enoai? a
i?aeoe/i?e ?iaio? e?ea??a iaa?ieia?a.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? o iaa?ieia?/ieo a?aeae?eaiiyo
?1 ? ?2 iaeanii? ee?i?/ii? e?ea?i? ?i. Eae?i?ia i?noa Aeiiaoeueea,
iaa?ieia?/iiio a?aeae?eaii? i?nueei? e?ea?i? ?6 i?noa Aeiiaoeueea,
iaa?i-eia?/iiio a?aeae?eaii? i?nueei? e?ea?i? ?1 i?noa Iae??aee,
iaa?ieia?/iiio a?aeae?eaii? i?nueei? e?ea?i? ?3 i?noa ssneioaaoa, a
oaeiae o iaa?ieia?/iiio a?aeae?eaii? a?enueeiai-iaaee/iiai aini?oaeth
i?noa ??i?iue Ee?anueei? iaeano?.

Iniaenoee aianie caeiaoaa/a.

O an?o oai?eo aaoi?ii iniaenoi i?iaiaeeeinue iaa?ieia?/ia ianoaaeaiiy ?
caiiaithaaeenue niaoe?aeueii ?ic?iaeai? ea?oe niinoa?aaeaiiy.
I?iaaaeaiee aiae?c aeaieo ?ioiieia?/iiai ianoaaeaiiy, ?aioaaiia?ai ?
eiii‘thoa?ieo oiiia?ai o iaoe??o?a, ui niinoa??aaeenue. Aaoi?ii
?ic?iaeaia iaoiaeeea aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio, noaia
?ioiiei?aaoth/i? oa?ai?? eaaai?cieii, iaoiaeeea e?eoaaiiy aae?e-iaiiiaei
eaca?ii oai?eo ia NIE?. Caeiaoaa/ai aia?oa aeei?enoaiee iaoiae IOIO aeey
e?eoaaiiy oai?eo c ?aoeaeoi?iei neiae?iiii. Iaea?aeai? aeai? naiino?eii
iienai?, ca?oiiaai? a oaa-eeoe? e ia?iaeai? ca aeiiiiiaith noaoenoe/ieo
iaoiae?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

Iniiai? iieiaeaiiy aeena?oaoe?? iaaiai?ai? ia can?aeaii? oiaa?enoaa
iaa?ieia?a ? ineo?ao??a i. Aei-iaoeueea ? Aeiiaoeueei? iaeano? (1996,
1997), aeaio iaoeiai-i?aeoe/ieo eiioa?aioe?yo ii?oieia?a Aeiiaoeueei?
iaeano? (1994, 1995), iaoeiai-i?aeoe/i?e eiioa?aioe?? o?c?ieia?a
Aeiiaoeueei? iaeano? (1995).

Aeena?oaoe?y iaaiai?aia ia i?aeeaoaae?aeueiiio can?aeaii? eaoaae?e
ia?aiaeo oai?ia c eo?nii iae-?io??o?a?? oa iaaee/ii? aaiaoeee ? eaoaae?e
aeeoy/i? oa caaaeueii? iaa?ieia?? c eo?nii iae?i?ioiieia?? ?
?aoeaenioa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai.

Ioae?eaoe??.

Ca oaiith aeena?oaoe?? iioae?eiaaii 10 iaoeiaeo ?ia?o, o oiio /ene? 8
iniaenoi: 3 noaoo? a iaoei-aeo aeo?iaeao, 3 noaoo? o ca??ieeao iaoeiaeo
i?aoeue, oa 4 oace eiioa?aioe?e.

Ianya ? no?oeoo?a ?iaioe.

Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, 4 ?icae?e?a
aeanieo aeine?aeaeaiue, i?aenoie?a, aeniiae?a ? i?aeoe/ieo
?aeiiaiaeaoe?e. ?iaioa aeeiiaia ia 152 noi??ieao iaoeiiieniiai oaenoo,
i?noeoue 32 oaaeeoe? ? 11 iaethie?a. Nienie e?oa?aoo?e aeeth/a? 112
a?o/eciyieo ? 116 ca?oa?aeieo aeaea?ae.
Ci?no ?iaioe.

Oa?aeoa?enoeea oai?eo ? iaoiaee aeine?aeaeaiiy.

O iaa?ieia?/iiio a?aeae?eaii? iaeanii? ee?i?/ii? e?ea?i? ?i. Eae?i?ia,
i. Aeiiaoeueea c 1992 ii 1997 ?iee ia e?eoaaii? ciaoiaeeeinue 148 oai?eo
ia NIE? a?eii a?ae 20 aei 67 ?ie?a. *ieia?e?a aoei 130 (87,8%),
ae?iie-18(12,2%). O?eaae?noue caoai?thaaiiy noaiiaeea: aei 1 ?ieo -19,6
%, a?ae 1 ?ieo aei 6 ?i-e?a — 25,7%, a?ae 6 aei 10 ?ie?a — 33,8%,
a?eueoa 10 ?ie?a — 20,9%. A?aoiaoth/e iniaeeaino? ee?i?/ii? ea?oeie,
aeai? aeiaeaoeiaeo ianoaaeaiue, oai?? aoee ?icae?eai? ia 3 a?oie: ia?oa
— c ?aoeaeoi?iei neiae?iiii — 46 (31,1%), ae?oaa- c ei??ioeaaei
neiae?iiii- 97 (65,5%), o?aoy -c ei??ioeaai-noaeeiiei neiae?iiii — 5
(3,4%).

Aeey ae??oaiiy iinoaaeaieo o ?iaio? caaaeaiue i?iaiaeeeinue eiiieaenia
ianoaaeaiiy oai?eo, yea aeeth/aei ca?? nea?a ? aiaiiaco, aea/aiiy
iaa?ieia?/iiai noaoono, eaai?aoi?i? oa ?ino?oiaioaeuei? iaoiaee
aeine?aeaeaiiy.

Aeey aea/aiiy ?ioiiiai noaoono aeei?enoiaoaaee oae? ?ioiieia?/i? oanoe:
a?aeiinio ? aaniethoio e?euee?noue O-e?ioioeeo?a oa ?o noanoaioe?e Th,
Ts, Th/Ts, ?AOE c OAA, a?aeiinio ? aaniethoio e?euee?noue A-e?ioioeeo?a,
ai?no ?ioiiaeiaoe?i?a A, M, G ca Iai/?i?, eiioeaio?aoe?th oee?eoethth/eo
?ioiieo eiiieaen?a.

?c ?ino?oiaioaeueieo iaoiae?a i?iaiaeeeanue niiiaeeeia?ao?y
iiia?aeiai-e?eaeiaiai a?aeae?eo o?aaoa, eiii‘thoa?ia oiiia?ao?y,
oeueo?acaoeiaa aeiiea?ia?ao?y noaeei ieaei?o e?ioe?aie, ?aiaacia?ao?y,
oa?iia?ao?y i?a.

Noaoenoe/io ia?iaeo ?acoeueoao?a i?iaiaeeee iaoiaeaie aa??aoe?eii?
noaoenoeee c canoinoaaiiyi t-e?eoa??th Nouethaeaioa. Ei?aeyoe?eiee
aiae?c cae?enithaaee ca aeiiiiiaith i?ia?aie Excel.

?acoeueoaoe aeine?aeaeaiue.

Ie aea/eee ?ioiiee noaoon o 78 oai?eo c ?aoeaeoi?iei ? ei??ioeaaei
neiae?iiaie NIE?. 30 in?a i?eciaiiai a?eo aac iaoieia?? o?aaoa neeaee
eiio?ieueio a?oio.

O a?oi? oai?eo c ?aoeaeoi?iei neiae?iiii on? ?ioiieia?/i? iieacieee
caeeoaeenue o iaaeao ii?ie, ca aeiyoeii eiioeaio?aoe?? Ig A, ui aoea
i?aeaeuaia ? noaiiaeea 2,210,20 a/e.

O a?oi? oai?eo c ei??ioeaaei neiae?iiii aeyaeai? a?eueo cia/i? c?ooaiiy
a ?ioiiiio noaoon?: aeyaeaia cieaeaiiy aaniethoii? ? a?aeiinii?
e?eueeino? O-e?ioioeeo?a — 685,2143,2o109/e ? 43,22,2% a?aeiia?aeii;
ci?aa?aeiioaiiy Th/Ts ii?ooaia a a?e Th-6,7; ooieoe?iiaeueia aeoeai?noue
O-e?ioioeeo?a aoea cieaeaia a ?aaeoe?? ?AOE c OAA — 57,12,3%, aaniethoia
? a?aeiinia e?euee?noue A-e?ioioeeo?a aoea i?aeaeuaia: 408,140,2 o109/e
? 25,6 2,8% a?aeiia?aeii; a?aei?/aia aeenaaiiaaeiaoe?iai?y, ui
ae?aaeaeanue o i?aeaeuaii? eiioeaio?aoe?? IgA — 3,20,34 a/e ? IgG —
15,62,29 a/e, IgM caeeoaany a iaaeao ii?ie-1,280,23 a/e, ai?no Oe?E
i?aeaeuoaaany aei 184,532,6 iea/ie.

Ie aea/aee aieea o?eaaeino? caoai?thaaiiy ia ?ioiieia?/io ?aaeoeai?noue
oai?eo ia NIE?.

O a?oi? oai?eo c o?eaae?noth caoai?thaaiiy aei iaeiiai ?ieo an?
?ioiieia?/i? iieacieee aoee a iaaeao ii?ie.

O a?oi? oai?eo c o?eaae?noth caoai?thaaiiy a?ae iaeiiai ?ieo aei iyoe
?ie?a aeyaeai? cia/i? ii?ooaiiy ?ioiii? ?aaeoeaiino?: cieaeaiiy
aaniethoii? ? a?aeiinii? e?eueeino? O-e?ioioeeo?a — 676,1163,9o109/e ?
45,5 2,2% a?aeiia?aeii; ci?aa?aeiioaiiy Th/Ts ii?ooaia a a?e Th — 6,6;
cieaeaiiy ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a o ?aaeoe?? ?AOE c
OAA-52,2 2,4%, aaniethoia ? a?aeiinia e?euee?noue A-e?ioioeeo?a aoea
i?aeaeuaia: 377,634,5o109/e ? 22,42,7% a?aeiia?aeii; i?aeaeuaiiy
eiioeaio?aoe?? IgA- 3,80,31 a/e ? IgG — 15,72,18 a/e, IgM caeeoaany a
iaaeao ii?ie — 1,29 0,23 a/e, eiioeaio?aoe?y Oe?E i?aeaeuoaaeany aei
177,5 34,8 iea/ie.

O a?oi? oai?eo c o?eaae?noth caoai?thaaiiy iiiaae iyoue ?ie?a aeyaeaia
a?eueo ae?aaeaia i?eai?-/aiiy ?ioi?oaoo, i?ae o iiia?aaei?e a?oi?:
cieaeaiiy aaniethoii? oa a?aeiinii? e?eueeino? O-e?ioioeeo?a-613,4
125,1o109/e ? 40,82,5% a?aeiia?aeii; ci?aa?aeiioaiiy Th/Ts ii?ooaia a
a?e Th-6,7; cieaeaiiy iieaciee?a ?AOE c OAA-50,12,5%; i?aeaeuaiiy
aaniethoii? oa a?aeiinii? e?eueeino? A-e?ioioeeo?a:-432,740,3 o109/e ?
26,83,4% a?aeiia?aeii; i?aeaeuaiiy eiioeaio?aoe?? IgA-3,10,31 a/e ?
IgG-20,5 3,36 a/e, IgM ia ci?ithaaany-1,310,22 a/e, eiioeaio?aoe?y
Oe?E aoea i?aeaeuaia — 265,945,2 iea/ie.

?ioiiei?aaoth/a oa?ai?y eaaai?cieii.

Aeey ei?aeoe?? ii?ooaiue ?ioiieia?/ii? ?aaeoeaiino? ie i?ecia/aee
eaaai?cie oai?ei c ei??ioeaaei neiae?iiii NIE?.

Iaoai?ci ae?? eaaai?cieo iiaycaiee c eiai aieeaii ia noi?ani?i? ee?oeie,
ye? aeoeaii aiee-aathoue ia ?icaeoie ?ioiieia?/ii? oiea?aioiino?,
i?iaeoeoe?th aioeaai?a, ?aaeoe?e a?ia?/ooeeaino? niia?eueiaiiai oeio.
Aenia?eiaioaeueieie aeine?aeaeaiiyie inoaii?o ?ie?a i?aeoaa?aeaeai?
aeai? i?i ?aaoeyoe?th aeoeaiino? noi?ani??a eaaai?cieii (E.O.Aieei,
1995).

A?e iaoe??io?a eieeaaany a?ae 31 aei 60 ?ie?a, o?eaae?noue caoai?thaaiiy
noaiiaeea a?ae 6 i?n. aei 15 ?ie?a. ?ioiiiiaeoethth/a oa?ai?y
i?iaiaeeeanue o eiiieaen? c iaaeeeaiaioicieie ? o?c?ioa?aiaaoe/ieie
iaoiaeaie e?eoaaiiy.

Iieacaiiyi aei i?ecia/aiiy ?ioiiei?aeoe?? aaaaeaee cieaeaiiy e?eueeino?
oa ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a o ?aaeoe?yo O-?IE ? ?AOE c
OAA, ii?ooaiiy ni?aa?aeiioaiue Th/Os. Ia?aae ii/aoeii e?eoaaiiy o 70
oai?eo aecia/aee /ooeea?noue O-e?ioioeeo?a aei eaaai?cieo in vitro.

Aeey oeueiai a eoeueoo?o e?ioioeeo?a aeiaeaaaee eaaai?cie aeicith 2
iea/ie. Iaea?aeai? ?acoeueoaoe aeicaieeee ?icae?eeoe oai?eo ia aea?
a?oie. Ia?oo a?oio neeaaeaee 57 (81,4%) oai?eo, o yeeo a?aei?/aeinue
i?aeaeuaiiy O-?IE, Th ? Ts, ii?iae?caoe?y ni?aa?aeiioaiiy Th/Os,
o ae?oao a?oio oa?eoei 13 (18,6%) iaoe??io?a, ?ioiieia?/i? iieacieee
yeeo ia ci?ieeenue. Oai?ei c a?aenooi?noth /ooeeaino? e?ioioeeo?a aei
eaaai?cieo i?aia?ao i?ecia/aany aeicith 75 ia ia aeiao /a?ac aeaiue
i?ioyaii aeaio oeaei?a (eo?niaa aeica-600 ia). Aeeiai?ea ?ioiieia?/ieo
iieaciee?a aea/aeanue /a?ac 15 ? 30 aei?a. Ca ia??iae niinoa?aaeaiiy
?ioiieia?/i? iieacieee a oe?e a?oi? ?noioii ia ci?ithaaeenue. Iaie aoa
c?iaeaiee aeniiaie i?i oa, ui ?ioiiiiaeoethth/o oa?ai?th iaaeioe?eueii
i?iaiaeeoe oai?ei c a?aenooi?noth /ooeeaino? e?ioioeeo?a aei eaaai?cieo
in vitro, o ca‘yceo c oeei iiaeaeueoa aeine?aeaeaiiy i?iaiaeeeinue
o?eueee a a?oi? oai?eo, o yeeo aeyaeaia /ooeea?noue aei eaaai?cieo.

Aeey aecia/aiiy iioeiaeueiiai ?aaeeio e?eoaaiiy i?ecia/aee ??ci? aeice ?
noaie aaaaeaiiy eaaai?cieo. Ia?oa a?oia (19 oai?eo) iaea?aeoaaea- ii 75
ia eaaai?cieo /a?ac aeaiue i?ioyaii iaeiiai oeaeiy (eo?niaa aeica -300
ia), ae?oaa a?oia (20 oai?eo)- ii 75 ia /a?ac aeaiue i?ioyaii aeaio
oeaei?a (eo?niaa aeica -600 ia), ? o?aoy (18 oai?eo) — ii 150 ia ia?o?
o?e aei? eiaeiiai oeaeiy i?ioyaii o?ueio oeaei?a (eo?niaa aeica — 1350
ia).

O ia?o?e a?oi? aei e?eoaaiiy aoee aeyaeai? ??ci? ii?ooaiiy ?ioi?oaoo:
cieaeaiiy a?aeiinii? e aanietho-ii? e?eueeino? O-?IE-42,52,3% ?
683,7112,8o109/e a?aeiia?aeii; cieaeaiiy Oh — 41,51,2% ? Ts-6,1 0,9%,
ci?ia ni?aa?aeiioaiiy Th/Ts ia ei?enoue Th-6,8; cieaeaiiy ?AOE c
OAA-IgG-16,192,72 a/e; ca?eueoaiiy Oe?E-198,730,8 iea/ie.

*a?ac 7 ae?a a?ae ii/aoeo ?ioiiei?aeoe?? ?ioiieia?/i? iieacieee
iie?iooaaeenue: i?aeaeuoaaeanue a?aeiinia e aaniethoia e?euee?noue O-?IE
— 56,22,7% ? 1052,1130,2o109/e a?aeiia?aeii ? Oh — 57,91,3%, Ts —
15,10,8%, ii?iae?coaaeinue ni?aa?aeiioaiiy Th/Ts-3,8; i?aeaeuoaaeanue
?AOE c OAA — 63,82,5%, cieaeoaaeanue a?aeiinia e aaniethoia e?euee?noue
A-?IE — 17,81,7% ? 315,536,4o109/e a?aeiia?aeii; cieaeoaaeenue IgA —
2,200,18a/e ? IgG-10,532,70a/e; cieaeoaaeenue Oe?E-117,427,6 iea/ie.

*a?ac 15 ae?a a?ae ii/aoeo e?eoaaiiy eaaai?cieii ?ioiieia?/i? iieacieee
iiaa?oaeenue aei aeo?aeiiai cia/aiiy: O-?IE-44,32,5% ? 692,3125,3o109/e
a?aeiia?aeii; Oh — 43,71,4%, Ts-6,01,0%, ni?aa?aeiioaiiy Th/Ts-7,1; ?AOE
c OAA-55,72,8 %, a?aeiinia e aaniethoia e?euee?noue A-?IE — 24,2 2,2% ?
426,536,8o109/e a?aeiia?aeii; IgA-2,830,27 a/e, IgG -15,102,65 a/e; Oe?E
— 200,132,3 iea/ie.

Iano?eeee aoaeo i?ney i?iaaaeaiiai e?eoaaiiy i?eionea ian o ianooii?e
a?oi? i?aeaeueoe eo?-niao aeico eaaai?cieo aei 600 ia. Aeeiai?ea
?ioiieia?/ieo iieaciee?a o oai?eo ae?oai? a?oie ioe?-ithaaeanue /a?ac 15
? 30 aei?a a?ae ii/aoeo e?eoaaiiy.

Aei e?eoaaiiy aeyaeaiee ?ioiieia?/iee aeenaaeain: cieaeaiiy a?aeiinii?
oa aaniethoii? e?eueeino? O-?IE-42,3 2,4 % ? 679,6 115,7o109/e
a?aeiia?aeii; cieaeaiiy Oh-42,41,3%, Ts-6,30,8%, ii?ooaiiy
ni?aa?aeiioaiiy Th/Ts-6,7; i?aeaeuaiiy ?AOE c OAA — 53,2 2,7%,
i?aeaeuaiiy a?aeiinii? e aaniethoii? e?eueeino? A-?IE-24,92,5% ?
421,730,1o109/e a?aeiia?aeii; i?aeaeuaiiy IgA-3,210,34 a/e ? IgG-
16,222,70 a/e; i?aeaeuaiiy Oe?E — 191,631,2 iea/ie.

*a?ac 15 ae?a a?ae ii/aoeo ?ioiiei?aeoe?? ?ioiieia?/i? iieacieee
a?aeiiaethaaeenue aei ii?ie: O-?IE-57,12,6% ? 1182,1150,8o109/e
a?aeiia?aeii; Oh-58,91,7%, Ts-15,21,2%, ni?aa?aeiioaiiy Th/Ts-3,9; ?AOE
c OAA — 66,22,6 %, a?aeiinia e aaniethoia e?euee?noue A-?IE-15,92,1% ?
318,636,3o109/e a?aeiia?aeii; IgA-2,150,19 a/e, IgG — 10,362,64 a/e;
Oe?E-121,526,9 iea/ie.

*a?ac 30 ae?a a?ae ii/aoeo i?iaaaeaiiai e?eoaaiiy eaaai?cieii
?ioiieia?/i? iieacieee cieaeoaaeenue, iaeiae caeeoeeenue aeueie a?ae
aeo?aeieo cia/aiue: O-?IE-51,22,4% ? 862,1136,7o109/e a?aeiia?aeii;
Oh-52,71,3%, Ts -11,20,8%, ni?aa?aeiioaiiy Th/Ts — 4,7; ?AOE c OAA —
60,62,7%, a?aeiinia e aaniethoia e?euee?noue A-?IE-20,92,3% ?
371,837,2o109/e a?aeiia?aeii; IgA-2,920,21 a/e, IgG- 12,112,52 a/e;
Oe?E- 156,531,4 iea/ie.

Cieaeaiiy ?ioiieia?/ieo iieaciee?a ia 30 aeiao a?ae ii/aoeo
?ioiiei?aeoe?? i?eioneei ian o ianooii?e a?oi? i?aeaeueoe eo?niao aeico
eaaai?cieo aei 1350 ia.

Aeeiai?ea ?ioiieia?/ieo iieaciee?a o oai?eo o?aouei? a?oie
ioe?ithaaeanue /a?ac 15 ? 30 aei?a a?ae ii/aoeo e?eoaaiiy.

Aei ?ioiiei?aaoth/i? oa?ai?? aeyaeaii ii?ooaiiy ?ioiieia?/ieo
iieaciee?a: cieaeaiiy a?aeiinii? e aaniethoii? e?eueeino? O-?IE —
41,92,5% ? 437,0124,5o109/e a?aeiia?aeii; cieaeaiiy Oh — 42,31,3% ?
Ts-6,30,8%, ii?ooaiiy ni?aa?aeiioaiiy Th/Ts — 6,7; i?aeaeuaiiy ?AOE c
OAA-55,12,5%, i?aeaeuaiiy a?aeiinii? e aaniethoii? e?eueeino? A-?IE
24,92,7% ? 411,230,6o109/e, i?aeaeuaiiy IgA-3,200,33 a/e ? IgG-16,042,70
a/e; i?aeaeuaiiy Oe?E-185,629,5 iea/ie.

*a?ac 15 ae?a a?ae ii/aoeo e?eoaaiiy eaaai?cieii ?ioiieia?/i? iieacieee
a?aeiiaethaaeenue aei ii?ie: O-?IE-55,32,8% ? 1096,5 142,7o109/e
a?aeiia?aeii; Oh-57,71,4%, Ts-14,60,9%, ni?aa?aeiioaiiy Th/Ts — 4,0;
?AOE c OAA-64,92,6%, a?aeiinia e aaniethoia e?euee?noue A-?IE-17,22,0% ?
318,532,8 109/e a?aeiia?aeii; IgA-2,890,31 a/e, IgG-10,452,69 a/e;
Oe?E-110,631,5 iea/ie.

*a?ac 30 ae?a a?ae ii/aoeo ei?aeoe?? ?ioiieia?/i? iieacieee
cieaeoaaeenue, iaeiae caeeoaeenue aeueie a?ae aeo?aeieo cia/aiue:
O-?IE-50,72,6% ? 794,8131,6o109/e a?aeiia?aeii; Oh-51,31,5%, Ts —
11,41,2%, ni?aa?aeiioaiiy Th/Ts — 4,5; ?AOE c OAA — 58,22,6%,
a?aeiinia e aaniethoia e?euee?noue A-?IE — 19,62,3% ? 373,4 32,9o109/e
a?aeiia?aeii; IgA — 2,410,26 a/e, IgG — 12,112,39 a/e; Oe?E-152,736,1
iea/ie.

Iaie aoa c?iaeaiee aeniiaie i?i oa, ui i?aeaeuaiiy eo?niai? aeice
eaaai?cieo aei 1350 ia ia i?ecaiaeeei aei iineeaiiy ?ioiiiiaeoethth/iai
aoaeoo ii??aiyii c iieacieeaie, iaea?aeaieie a iiia?aaei?e a?oi?.

O 6 oai?eo a?aecia/ai? ??ci? oneeaaeiaiiy i?ney e?eoaaiiy eaaai?cieii. O
ia?o?e a?oi? a iaeiiai oai?iai a?aecia/aany aenei ia oe???. O ae?oa?e
a?oi? a iaeiiai iaoe??ioa a?aei?/aeanue eaeeiiai?y, ioaeioa oa
aethaaiiy. O o?ao?e a?oi? ?icaeaaeanue iaea?eueoa e?euee?noue
oneeaaeiaiue — o /ioe?ueio iaoe??io?a: eaeeiiai?y-o o?ueio; ioaeioa,
aethaaiiy-o aeaio; ae?a?ay- a iaeiiai; a?ia?oa?i?y-a iaeiiai. O /anoeie
oai?eo niinoa??aaeinue ii?aeiaiiy neiioii?a. On? neiioiie i?ioiaeeee
naiino?eii /a?ac 1-2 oeaei? i?ney a?aei?ie i?aia?aoo.

Oaeei /eiii, i?iaaaeai? aeine?aeaeaiiy iieacaee, ui ?ioiiei?aeoe?y
eaaai?cieii c eo?niaith aei-cith 600 ia ? iioeiaeueiith, oiaoi aea?
no?eeee ?ioiieia?/iee aoaeo ? i?i?iaeueio e?euee?noue iia?/ieo yaeu.

Aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio.

Iaie ?ic?iaeaia iaoiaeeea e?eoaaiiy oai?eo ia NIE? aiaeiethiaaeueiei
aaaaeaiyi i?aaei?ci-eiio. Iieacaiiyi aei e?eoaaiiy aoa ae?aaeaiee
aieueiaee neiae?ii, coiiaeaiee caaino?aiiyi o?eaa-eiai o?ii?/iiai NIE?.
Ia?aaaaith oeueiai niiniao ? aaciina?aaei? aaaaeaiiy i?aia?aoo a
noaa?ao-ii?aeaeueiee i?ino??, ui aeicaiey? aeinyaoe a?eueo oaeaeeiai ?
ae?aaeaiiai e?eoaaeueiiai aoaeoo. Aiaeiethiaaeueia aaaaeaiiy
i?aaei?cieiio ia aeeeeea? ooeiaeaeaiiy /e iiae?aciaiiy ia?aiai? oeaieie.

Ioieoe?th ethiaaeueiiai i?inoi?o cae?enithaaee ca noaiaea?oiith
iaoiaeeeith o iieiaeaii? oai?iai eaaea/e ia aioe?. I?aia?ao i?ecia/aany
aeicith 1 ia/ ia ea aaae. I?aaei?cieii aaiaeeany iaeei ?ac, i?e
a?aenooiino? ee?i?/iiai aoaeoo — iiaoi?ii /a?ac iaeei aeaiue
(i?ecia/aeinue aei 3 ?i‘?eoe?e). I?iaiaeeeinue ?aiaeii?ciaaia
aeine?aeaeaiiy o 28 oai?eo, yeei i?ecia/aeenue aiaeiethiaaeuei? aeieaaee
a eiiieaen? c iaaeeeaiaioiciith oa?ai??th, yea aeeth/aea i?ecia/aiiy
oo?inai?aeo, ?iaeiiaoaoeeio, niaciia?th, aeeeeioaiaeo, o?aioaeo,
ne?aeaeoaeo. I?e i‘yciai-oii?/iiio neiae?ii? canoiniaoaaee n??/aiieeneo
iaaiac?th oa o?ieainei; i?e aaaaoi-noaeeiiiio neiae?ii? i?aia?aoe
aaeaaeiie.

Aoaeoeai?noue e?eoaaiiy ioe?ithaaeanue ca cieaeaiiyi ae?aaeaiino?
aieueiaiai neiae?iio, ca?eueoaiiyi ia?io ?oo?a o iiia?aeiaiio a?aeae?e?
o?aaoa ? ciaioaiiyi neiioii?a iaoyao. O an?o oai?eo aei e?eoaaiiy
a?aecia/aeinue iaiaaeaiiy ia?io ?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa:
iaoeee ooeoaa aia?aae- 41,310,2;iaoeee ooeoaa iacaae-10,22,7; iaoeee
ooeoaa ia aiee — 23,55,6; aoee iiceoeaieie neiioiie iaoyao: neiioii
Eanaaa — 44,29,5.

I?ney aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio o 60,7% oai?eo
a?aecia/aiee ?aa?an iaa?iei-a?/ii? neiioiiaoeee — ca?eueoaiiy ia?io
?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa, cieaeaiiy ae?aaeaiino? neiioii?a
iaoyao: iaoeee ooeoaa aia?aae- 66,410,5; iaoeee ooeoaa iacaae- 15,3 3,0;
iaoeee ooeoaa ia iaeaeaa aiee — 38,16,4; neiioii Eanaaa — 62,1 12,1.

I?ney ia?oiai aaaaeaiiy iie?ioaiiy noaio a?aecia/eee 35,7% oai?eo, i?e
oeueiio o 21,4% — aieueiaee neiae?ii aoa eoi??oaaiee iiai?noth, o 17,9%
— cia/ii ciaioeany. 18 iaoe??ioai, ye? ia a?aecia/aee ?noioiiai
iie?ioaiiy noaio, i?iaiaeeeenue iiaoi?i? ?i‘?eoe?? i?aaei?cieiio.

Aeiaeaoeia? aiaeiethiaaeuei? aaaaeaiiy aeicaieeee i?aeaeueoe i?ioeaio
oai?eo c iiceoeaiei aoaeoii c 35,7% aei 60,7%. ?c 11 oai?eo, yeei aoei
i?iaaaeaii 4 ?i‘?eoe??, o aeiaeiiai ia niinoa??aaeinue ae?aaea-iiai
cieaeaiiy aieueiaiai neiae?iio. Ie c?iaeee aeniiaie i?i oa, ui ia ne?ae
i?ecia/aoe aeiaeaoeia? aaaaeaiiy i?aaei?cieiio, yeui ia niinoa??aa?oueny
aoaeo i?ney o?ueioe?aoiiai aaaaeaiiy i?aia?aoo.

Aeey oieeiaiiy oneeaaeiaiue iaiao?aeii aeio?eioaaoenue i?aaeea
ethiaaeueii? ioieoe?? ? oaiio aaa-aeaiiy i?aia?aoo. ?c 28 oai?eo, yeei
i?iaiaeeee aiaeiethiaaeueia aaaaeaiiy i?aia?aoo, 4 (14,3%) a?aecia/eee
iiyao aieiaiiai aieth, i?ney i?ecia/aiiy iino?eueiiai ?aaeeio oeae
neiioii i?ioiaeea.

Aea/aeanue aoaeoeai?noue ??cieo noai e?eoaaiiy o 93 oai?eo ia NIE?. On?
iaoe??ioe aoee ?icae?eai? ia o?e a?oie.

Aei ia?oi? a?oie oa?eoee 35 oai?eo, yeei i?iaiaeeeanue o?eueee
iaaeeeaiaioicia oa?ai?y, yea aeeth/aea i?ecia/aiiy ?iaeiiaoaoeeio,
aeeeeioaiaeo, niaciia?th, o?aioaeo, oo?inai?aeo ? ne?aeaeoaeo. Ae?oao
a?oio noaiiaeee 30 oai?eo, yeei i?iaiaeeeenue ai?aeo?aeuei? aeieaaee
i?aaei?cieiiii aeicith 1 ia/ia ea aaae c iiaiea?iii 0,5%-50,0 ie o
ii?aeiaii? c iaaeeeaiaioiciith ei?aeoe??th. O?aoth a?oio noaiiaeee 28
oai?eo, yeei ii?yae c iaaeeeaiaioiciith oa?ai??th i?iaiaeeeinue
aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio.

O a?oi? oai?eo, ye? iaea?aeoaaee o?eueee iaaeeeaiaioicio oa?ai?th,
i?ioeaio iiceoeaieo ?acoeue-oao?a aoa cia/ii iaioee, i?ae o ae?oa?e ?
o?ao?e a?oiao ? neeaaeaa 31,4%.

O ae?oa?e a?oi? ?acoeueoaoe e?eoaaiy aoee e?aueie, i?ae o ia?o?e, cia/ia
ciaioaiiy aieueiaiai neiae?iio a?aecia/eee 53,3% oai?eo.

Iaeaoaeoeai?oei aoei e?eoaaiiy oai?eo o o?ao?e a?oi?, ye?e i?iaiaeeeinue
aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio: ia iie?ioaiiy noaio aeacoaaei
60,7% iaoe??io?a. Iaie aea/aeanue aoaeoeai?noue ??cieo noai e?eoaaiiy a
caeaaeiino? a?ae o?eaaeino? aieueiaiai neiae?iio.

Iaea?eueo aoaeoeaiei aoei e?eoaaiiy iaoe??io?a, o yeeo o?eaae?noue
caoai?thaaiiy ia ia?aaeuoaaea iaeiiai ?ieo. O oai?eo, ui iaea?aeoaaee
ai?aeo?aeuei? aeieaaee, iiceoeaiee aoaeo aoa iaea?aeaiee o 57,1%, o
oai?eo, yeei ii?yae c iaaeeeaiaioiciith oa?ai??th aeeiioaaeinue
aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio — o 69,2%.

O oai?eo c o?eaae?noth caoai?thaaiiy a?eueoa iaeiiai ?ieo o an?o a?oiao
i?ioeaio iiceoeaieo ?acoeueoao?a aoa ieae/ei, i?ae o iaoe??io?a c
o?eaae?noth oai?iae aei iaeiiai ?ieo: ia?oa a?oia — 34,3%; ae?oaa a?oia
-43,8%, o?aoy a?oia — 53,5%.

I?iaaaeai? niinoa?aaeaiiy iieacaee, ui oni?o e?eoaaiiy aaaaoi a /iio
caeaaeeoue a?ae ?aiiuei? ae?aaiinoeee caoai?thaaiiy ? nai?/aniino?
i?iaaaeaiiy aaeaeaaoii? oa?ai??. Aiaeiethiaaeueia aaaaeaiiy
i?aaei?cieiio iiaeia aeei?enoiaoaaoe aeey eoi??oaaiiy aieueiaiai
neiae?iio o oai?eo ia NIE?.

E?eoaaiiy iaoiaeii aieeao iaaaoeaiiai oeneo, i?eeeaaeaiiai ia ieaeith

iieiaeio o?ea iaoe??ioa (IOIO).

Aeey e?eoaaiiy ?aoeaeoi?iiai neiae?iio iaie aia?oa canoiniaoaaany iiaee
o?c?ioa?aiaaoe/iee iaoiae c aeei?enoaiiyi iaoiaeo IOIO. Aieea ia ieaei?
e?ioe?aee cae?enith?oueny oaeei /eiii: ieaeith iieiaeio o?ea oai?iai
iii?uothoue o aaeooiio eaia?o i?eno?ith, yeo aa?iaoecothoue ia ??ai?
a?aa?ioe?a eeoaiaeo e?noie aeanoe/iei iiynii. Aaeooiiei ianinii
noai?ththoue iaaaoeaiee oene o eaia?? ieaaiith ?ic?yaeeith aei caaeaiiai
??aiy. Aaee/eia iaaaoeaiiai oeneo aei??aith? 20 ii ?o. no. ia ia?oiio
nooiai? ? 40 ii ?o. no. ia ae?oaiio. Aieea cae?enith?oueny i?ioyaii 40
oaeeei, iine?aeiaii ii 20 oa. ia eiaeiiio nooiai? .

Anoaiiaeaii, ui iaaaoeaiee oene, i?eeeaaeaiee aei ieaei?o e?ioe?aie
iaoe??ioa, aeeeeea? cia/i? c?ooaiiy oeaio?aeueii? ? ia?eoa?e/ii?
aaiiaeeiai?ee ca ?aooiie aeaiiioaaiiy /anoeie oee?eoethth/i? e?ia? a
?ie?nieo noaeeiao, ?icoaoiaaieo o cii? aieeao (A.A. Aeaaoy?ueia, 1987).
Aieea IOIO aeeeeea? i?aeaeuaiiy o?ainio?aeueiiai oeneo a noaeeiao
a?aeiia?aeii? ae?eyiee, ui a naith /a?ao i?ecaiaeeoue aei ca?eueoaiiy
?ieino? noaeeiiiai ?onea ? e?eueeino? e?ia? o iueiio.

E?eoaaiiy iaoiaeii IOIO i?iaiaeeee i?ney iaaeeeaiaioicii? ei?aeoe?? 22
oai?ei c ?aoeaeoi?iei neiae?iiii. *ieia?e?a aoei 18 (81,8%), ae?iie-4
(18,2%), a?e iaoe??io?a eieeaaany a?ae 35 aei 56 ?ie?a. O?eaae?noue
aieueiaiai neiae?iio noaiiaeea a?ae aeae?eueeio i?nyoe?a aei 10 ?ie?a.
E?eoaaeuei? naaine i?iaiaeeeenue /a?ac aeaiue, anueiai i?iaaaeaii 8
i?ioeaaeo?. Aei e?eoaaiiy a?aei?/aeinue iaiaaeaiiy ia?io ?oo?a o
iiia?aeiaiio a?aeae?e? o?aaoa, aoee iiceoeaieie neiioiie iaoyao: iaoeee
ooeoaa aia?aae- 41,18,9; iaoeee ooeoaa iacaae- 13,72,0; iaoee ooeoaa ia
iaeaeaa aiee- 33,78,1; neiioii Eanaaa — 37,310,1.

I?ney aieeao IOIO o 72,7% oai?eo a?aei?/ai? ?aa?an iaa?ieia?/ii?
neiioiiaoeee — ca?eueoaiiy ia?io ?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa,
ciaioaiiy ae?aaeaiino? neiioii?a iaoyao-o 68,2%; iaoeee ooeoaa aia?aae —
73,110,8; iaoeee ooeoaa iacaae — 28,13,1; iaoee ooeoaa ia iaeaeaa aiee —
46,46,7; neiioii Eanaaa — 72,110,5.

I?ney i?iaaaeaiiy aeaio naain?a IOIO o?eueee 2 oai?eo a?aei?oeee aeayea
iie?ioaiiy noaio, iaeiae aoaeo a?ae i?ioeaaeo?e aoa iano?eeei ? ia
a?aoiaoaaany iaie ye iiceoeaiee. I?ney o?ueio naain?a o 4 oai?eo
iaea?aeaiee no?eeee ee?i?/iee aoaeo, i?ney /ioe?ueio — o 10, i?ney iyoe-
o 16, i?ney oanoe — o 18 iaoe??io?a.

Ca?eueoaiiy e?eueeino? naain?a aei 6 aeicaieeei iaea?aeaoe iiceoeaiee
aoaeo o 18 (86,7%) oai?eo c ?aoeaeoi?iei neiae?iiii.

Aeey ia?eoea?caoe?? noaio i?e?ioee?eoeyoe?? on?i oai?ei i?ney eo?no
e?eoaaiiy i?iaiaeeee ?ai-a?ao?th ieaei?o e?ioe?aie. E??i a?coaeueiiai
eiio?ieth ioe?ithaaee iniiai? ia?aiao?e: oi?io ?aia?a-o?/ii? e?eai?,
?aaoey?i?noue ? ae?aaeai?noue aeiaeaoeiaeo coaoe?a, e?euee?nio ioe?ieo
aiie?ooaee a ii, a?aeoeeaiiy ?? aei aenioe eae?a?oaaeueiiai ?iioeueno,
/an aeieeiaiiy ieco?aeii? ? aeno?aeii? /anoeie e?eai?. Aei e?eoaaiiy
niinoa??aaeinue cieaeaiiy ?aia?ao?/ieo iieaciee?a, cieaeaiiy aiie?ooaee
eieeaaiue ioeueniai? oaee?, ia??cea cieaeaiiy /ano aiae?ioe ? /ano
?iciianthaeaeaiiy ioeueniai? oaee?. I?ney i?iaaaeaiiy e?eoaaeueieo
naain?a o 72,7% oai?eo iaee i?noea iciaee i?aeaeuaiiai oiiono a ieaei?o
e?ioe?aeao, a?aei?/aeinue ie?oaeaiiy aa?oeie, ca?eueoaiiy aiie?ooaee
e?iaiiaiiaiaiiy.

Iiaeaeueoa ca?eueoaiiy /enea naain?a ia i?aeaeuoaaei aoaeoeaiino?
oeueiai iaoiaeo e?eoaaiiy.

O 12 iaoe??io?a noa?oeo a?eiaeo a?oi aei ? i?ney i?ioeaaeo?e caienoaaee
AEA. A?coaeueia e e?euee?nia ioe?iea AEA ia aeyaeea iia??oaiiy ooieoe??
ei?iia?iiai e?iaiia?ao.

On? iaoe??ioe aeia?a ia?aiineee oeth i?ioeaaeo?o ? iaie ia aeyaeaii
iia?/ieo ae?e i?e i?iaaaeaii? e?eoaaeueieo naain?a IOIO.

E?eoaaiiy aae?e-iaiiiaei eaca?ii.

38 oai?ei i?iaiaeeeinue e?eoaaiiy aae?e-iaiiiaei eaca?ii, ?c ieo- 20
iaoe??io?a c ?aoeaeoi?iei ? 18 — c ei??ioeaaei neiae?iiaie NIE?. Oai?? c
?aoeaeoi?iei neiae?iiii iaea?aeoaaee o?c?ioa?aiaaoe/ia e?eoaaiiy a
eiiieaen? c iaaeeeaiaioiciith oa?ai??th (ianoa?i?aei? i?ioecaiaeuei?,
noaeeii? oa na/ia?ii? i?aia?aoe), a iaoe??ioe c ei??ioeaaei neiae?iiii
— i?ney iaaeeeaiaioicii?, ?ioiiiiaeoethth/i? oa?ai?? oa
aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio.

Iaoai?ci ae?? iecueei?ioaineaiiai eaca?iiai ii?ii?iaiiy iiaycaiee c
aieaoaioth/ith, ?ioiiei?aaoth/ith, nainea?e?coth/ith ?
o?io?ei?aaaia?aoeaiith ae??th, i?e oeueiio iii?oii iie?ioo?oueny
ooieoe?iiaeueia aeoeai?noue ia?aiai-iyciaiai aia?aoo (?.C. Naiinthe,
1997, I.E. Neiaaeeei, 1995).

E?eoaaiiy i?iaiaeeee aae?e-iaiiiaei eaca?ii c aeiaaeeiith oaee? 0,63
iei, iiooaei?noth 5-10 iAo ia ni2, noia?iee /an aieeao 5-10 oa, a?ae 10
aei 18 naain?a ia eo?n, aia?aaoe/ia u?euei?noue 0,1-0,5 Aeae/ni.
Aieeaaee ia i?iaeoe?ei? iaeano? ooeiaeaeaieo o?aaoe?a, i?aeo?aaoeaaeo
aeene?a ? ei??ioe?a, ii?ii?ithth/e ia?aaa?oaa?aeuei? oi/ee ia a?aenoai?
1,5 ni a?ae inoenoeo a?ae?inoe?a c iaio aie?a. Ia iiia?aeiai-e?eaeiao
ae?eyieo aeiaeaoeiai aieeaaee ca?eueoaiith aeicith ii?ii?iaiiy aei 4-7
Aeae/ni.

Aoaeoeai?noue oa?ai?? ioe?ithaaee ca ee?i?/ieie iieacieeaie:
ae?aaeai?noth aieueiaiai neiae?iio, neiioii?a iaoyao, a?aeiiaeaiiyi
aaaaoi-noaeeiieo ii?ooaiue, ca aeeiai?eith ?aiaacia?ao?/ieo iieaciee?a.

I?ney 5 naain?a eaca?ioa?ai?? 25% iaoe??io?a c ?aoeaeoi?iei ? 16,7% c
ei??ioeaaei neiae?iiaie a?aecia/aee ciaioaiiy aieueiaiai neiae?iio,
ca?eueoaiiy ia?io ?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa i?e iaoee?
ooeoaa aia?aae ? ia aiee.

I?ney 10 naain?a o 75% oai?eo c ?aoeaeoi?iei ? o 50,0% c ei??ioeaaei
neiae?iiaie a?aecia/aia iiceoeaia iaa?ieia?/ia aeeiai?ea. Aioaea?/ia
oiaea, iiaycaia c aieai ? iai?oaeaiiyi iyc?a nieie, ii?iae?coaaeanue o
73,2% iaoe??io?a. O an?o oai?eo /?oei ?aa?anoaaee neiioiie iaoyao, ia?i
?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa iiai?noth a?aeiiaeany o 42,1%
oai?eo.

I?ney 15 nain?a ee?i?/iee aoaeo a?aecia/eee 72,2% oai?eo c ei??ioeaaei
neiae?iiii, c ?aoeaeoi?iei neiae?iiii — /enei oai?eo c iiceoeaiei
?acoeueoaoii ia ci?ieeinue. Iiai?noth ?aa?anoaaee ii?ooaiiy /ooeeaino? o
66,7%, cia/ii ciaioeeenue o 22,2% oai?eo.

I?ae aieeaii e?eoaaiiy ii-??ciiio ?aa?anoaaee iaa?ieia?/i? neiioiie o
oai?eo c ?aoeae-oi?iei ? ei??ioeaaei neiae?iiaie NIE?. Ii?ooaiiy ia?io
?oo?a o iiia?aeiaiio a?aeae?e? o?aaoa aei e?eoaaiiy niinoa??aaeanue o
81,6% oai?eo, i?ney e?eoaaiiy a?i iiai?noth a?aeiiaeany o 65,0%
iaoe??io?a c ?aoeaeoi?iei ? o 55,6% c ei??ioeaaei neiae?iiaie; cia/ii
c??n o 35,0% c ?aoeaeoi?iei ? o 27,8% oai?eo c ei??ioeaaei neiae?iiaie.
I?ney i?iaaaeaiiai e?eoaaiiy ?aa?anoaaee neiioiie iaoyao nieiiiiiceiaeo
ei??ioe?a, oae neiioii Eanaaa ciaioeany o 85,0% oai?eo c ?aoeaeoi?iei
? a 66,7% c ei??ioeaaei neiae?iiaie.

Iiaeaeueoa ca?eueoaiiy e?eueeino? i?ioeaaeo? ia i?aeaeueei a?aenioea
oai?eo c iiceoeaiei ?acoeueoaoii. Oea aeicaieeei iai c?iaeoe aeniiaie,
ui 10 naain?a ii?ii?iaiiy aae?e-iaiiiaei eaca?ii ? iioeiaeueiith noaiith
aeey e?eoaaiiy oai?eo c ?aoeaeoi?iei neiae?iiii ? 15 naain?a- aeey
e?eoaaiiy oai?eo c ei??ioeaaei neiae?iiii NIE?.

Caa?oa? ia naaa oaaao oa, ui a a?oi? oai?eo c ?aoeaeoi?iei neiae?iiii,
yeei i?iaiaeeeinue e?eoaaiiy IOIO, ?acoeueoaoe e?eoaaiiy aoee e?aueie,
i?ae o iaoe??io?a, ui iaea?aeoaaee e?eoaaiiy aae?e-iaiiiaei eaca?ii, ?
iiceoeaia aeeiai?ea aeinyaiooa o 81,8% oai?eo.

Iaie ioe?ithaaeenue oaeiae a?aeaeaeai? ?acoeueoaoe e?eoaaiiy oai?eo ia
NIE?. O?eaae?noue niinoa?aaeaiiy noaiiaeea 1 ??e. On? iaoe??ioe aoee
?acae?eai? ia /ioe?e a?oie.

Aei ia?oi? a?oie oa?eoee 30 oai?eo c ?aoeaeoi?iei neiae?iiii, yeei
i?iaiaeeeanue o?eueee iaaeeeaiaioicia oa?ai?y. Ae?oao a?oio neeaee 22
oai?eo c ?aoeaeoi?iei neiae?iiii, yeei i?iaiaeeeanue iaaeeeaiaioicia
oa?ai?y o ii?aeiaii? c IOIO. O?aoth a?oio noaiiaeee 30 oai?eo c
ei??ioeaaei neiae?iiii, yeei ii?yae c iaaeeeaiaioiciith oa?ai??th
aeeiioaaeenue ai?aeo?aeuei? aeieaaee. Aei /aoaa?oi? a?oie oa?eoee 28
iaoe??io?a c ei??ioeaaei neiae?iiii, ye? iaea?aeaee eiiieaenio oa?ai?th,
ui aeeth/aea iaaeeeaiaioicio oa ?ioiiei?aaoth/o oa?ai?th,
aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio ? aae?e-iaiiiaee eaca?.

?acoeueoaoe e?eoaaiiy oai?eo c ?aoeaeoi?iei neiae?iiii o ia?o?e a?oi?,
ui iaea?aeoaaee o?eueee iaaeeeaiaioicio oa?ai?th, aoee a??o?, i?ae o
iaoe??io?a ae?oai? a?oie. O oe?e a?oi? a?aecia/aeinue a?eueo o?eaaea
ia?aaoaaiiy ia e?aeeo — 21,32,9 aei?a, aaeeea e?euee?noue caaino?aiue ia
??e — 4,30,7; o?eaae?noue ?ai?n?? aoea ei?iooith — 3,20,5 i?n.; o
ae?oa?e a?oi? oe? iieacieee noaiiaeee: 16,12,2; 8,42,3; 1,20,3
a?aeiia?aeii.

O oai?eo c ei??ioeaaei neiae?iiii na?aaei?e e?aeei-aeaiue o o?ao?e ?
/aoaa?o?e a?oiao aoa i?eaeecii iaeiaeiaee — 20,12,9 ? 19,22,1
a?aeiia?aeii; iaeiae o /aoaa?o?e a?oi? na?aaeiy o?eaae?noue ?ai?n?? aoea
aeiaoith- 7,62,2 i?n., a /anoioa caaino?aiue ia ??e iaioa — 1,70,3
ii??aiyii c o?aoueith a?oiith, aea oe? iieacieee noaiiaeee: 4,81,9 ?
2,50,5 a?aeiia?aeii.

Aeai?eoi e?eoaaiiy oai?eo ia NIE?.

Iaie ?ic?iaeaiee aeai?eoi aeeoa?aioe?eiaaiiai e?eoaaiiy oai?eo ia NIE?.
On? oai?? iica caeaaei?noth a?ae ee?i?/iiai neiae?iio iiaeii?
iaea?aeoaaoe iaaeeeaiaioicio oa?ai?th, ui i?noeoue: ianoa?i?aei?
i?ioecaiaeuei?, na/ia?ii?, noaeeii? i?aia?aoe oa aiaeueaaoeee. Oai?ei c
?aoeaeoi?iei neiae?iiii ie ?aeiiaiaeo?ii o?noue naain?a e?eoaaiiy
iaoiaeii IOIO aai aeanyoue naain?a ii?ii?iaiiy aae?e-iaiiiaei eaca?ii.

Iaoe??ioai c ei??ioeaaei neiae?iiii NIE?, o yeeo aeyaeai? ii?ooaiiy
?ioi?oaoo, iaiao?aeii i?ecia/aoe eaaai?cie eo?niaith aeicith 600 ia
i?e iayaiino? /ooeeaino? e?ioioeeo?a oai?iai aei i?aia?aoo in vitro.
Iaeii/anii c ?ioiiei?aaoth/ith oa?ai??th iieacaia aaaaeaiiy
i?aaei?cieiio a noa-a?aoii?aeaeueiee i?ino?? aeicith 1 ia/ea aaae /a?ac
aeaiue (aei 3 ?i?eoe?e). I?ney oeueiai oai?ei c ei??i-oeaaei neiae?iiii
ne?ae i?iaanoe 15 naain?a ii?ii?iaiiy aae?e-iaiiiaei eaca?ii.

Iao? aeine?aeaeaiiy iieacaee, ui e?eoaaiiy NIE? iiaeiia ii/eiaoeny ye
iiaeia ?ai?oa c aeei?enoaiiyi eiiieaeno ??cieo iaoiae?a e?eoaaiiy:
iaaeeeaiaioicii? ei?aeoe??, aiaeiethiaaeueiiai aaaaeaiiy i?aaei?cieiio,
o?c?ioa?aiaaoe/ieo iaoiae?a. Oa?ai?y iaoe??io?a c ??cieie neiae?iiaie
caoai?thaaiiy ia? nai? iniaeeaino? ? iiaeiia a?aoiaoaaoe o?eaae?noue
oai?iae, ae?aaeai?noue iniiaieo iaa?ieia?/ieo ii?ooaiue, a oaeiae
aoaeoeai?noue ?ai?oa canoiniaaieo e?eoaaeueieo caoiae?a.

Aeniiaee

1. O oai?eo ia NIE? aeyaeai? ii?ooaiiy ?ioiieia?/ii? ?aaeoeaiino?:
cieaeaiiy e?eueeino? ? ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a o
?aaeoe?yo O-?IE ? ?AOE c OAA, cieaeaiiy Oh ? Os, ci?ia ?o
ni?aa?aeii-oaiiy ia ei?enoue Oh, i?aeaeuaiiy e?eueeino? oa
ooieoe?iiaeueii? aeoeaiino? A-e?ioioeeo?a o ?aaeoe?yo A-?IE,
aeenaaiiaaeiaoe?iai?y ? i?aeaeuaiiy ai?noo Oe?E o ne?iaaooe? e?ia?. O
oai?eo c ?aoeaeoi?iei neiae?iiii ia a?aecia/ai? ii?ooaiiy ?ioiiiai
aiiainoaco, ca aeiyoeii i?aeaeuaiiy IgA o ne?iaaooe? e?ia?.

2. ?ioiiiiaeoethth/a oa?ai?y eaaai?cieii aoaeoeaia o oai?eo c
ei??ioeaaei neiae?iiii i?e cieaeaii? e?eueeino? O-noi?ani??a o
ne?iaaooe? e?ia? ? iayaiino? /ooeeaino? e?ioioeeo?a aei i?aia?aoo in
vitro.

3. Aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio iieacaia aeey eoi??oaaiiy
aieueiaiai neiae?iio o oai?eo c ei??ioeaaei neiae?iiii NIE?, yea
aeioe?eueii i?iaiaeeoe a eiiieaen? c iaaeeeaiaioiciith oa?ai??th, ui
i?noeoue i?ecia/aiiy ianoa?i?aeieo i?ioecaiaeueieo i?aia?ao?a,
aiaeueaaoee?a, na/ia?iieo ? noaeeiieo i?aia?ao?a. Aoaeoeai?noue
e?eoaaiiy caeaaeeoue a?ae o?eaaeino? caoai?thaaiiy ? iiaea aooe
i?aeaeuaia ca?eueoaiiyi e?aoiino? aaaaeaiiy i?aia?aoo (aei 3 ?i?eoe?e).

4. Canoinoaaiiy iaoiaeo iaaaoeaiiai oeneo, i?eeeaaeaiiai ia ieaeith
iieiaeio o?ea iaoe??ioa, iieacaia aeey e?eoaaiiy oai?eo c ?aoeaeoi?iei
neiae?iiii o eiiieaen? c iaaeeeaiaioiciith oa?ai??th.

5. Aeei?enoaiiy aae?e-iaiiiaiai eaca?a o eiiieaeni?e oa?ai?? ?
aoaeoeaiei o?c?i-oa?aiaaoe/iei iaoiaeii e?eoaaiiy iaa?ieia?/ieo i?iya?a
NIE?. O iaoe??io?a c ?aoeaeoi?iei neiae?iiii aae?e-iaiiiaee eaca?
iiaeiai i?ecia/aoeny ia oii? iaaeeeaiaioicii? oa?ai??, a a
iaoe??io?a c ei??ioeaaei neiae?iiii — i?ney aiaeiethiaaeueiiai
aaaaeaiiy i?aaei?cieiio.

6. Canoinoaaiiy eiiieaeniiai aeeoa?aioe?eiaaiiai e?eoaaiiy NIE?, ui
i?noeoue iaaee-eaiaioicio oa?ai?th, ?ioiiei?aeoe?th eaaai?cieii,
aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio, canoinoaaiiy IOIO ?
aae?e-iaiiiaiai eaca?a aeicaieeei i?aeaeueoe aoaeoeai?noue e?eoaaiiy c
31,4% aei 81,8% o oai?eo c ?aoeaeoi?iei neiae?iiii ? aei 72,2% — c
ei??ioeaaei.

I?AEOE*i? ?AEIIAIAeAOe??.

1. E?eoaaiiy oai?eo ia NIE? iiaeiia aooe aeeoa?aioe?eiaaiei ?
i?iaiaeeoeny c o?aooaaiiyi ii?ooaiiy ?ioiiiai noaoono, oi?ie ?
o?eaaeino? caoai?thaaiiy.

2. O an?o oai?eo ia NIE? ia?aae ii/aoeii e?eoaaiiy iaiao?aeii aea/eoe
noai ?ioiieia?/ii? ?aaeoeaiino?. Iayai?noue O-?ioiiaeao?oeeoo i?e
anoaiiaeai?e /ooeeaino? e?ioioeeo?a oai?eo aei eaaai?cieo in vitro ?
iieacaiiyi aei i?iaaaeaiiy ?ioiiiiaeoethth/i? oa?ai??.

3. Aeey aeinyaiaiiy no?eei? ?ioiieia?/ii? ei?aeoe?? iioeiaeueiith
noaiith i?ecia/aiiy eaaai?cieo ? 75 ia /a?ac aeaiue i?ioyaii aeaio
oeaei?a eo?niaith aeicith 600 ia.

4. Aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio iieacaia i?e ae?aaeaiiio
aieueiaiio neiae?ii? o oai?eo c ei??ioeaaei neiae?iiii NIE?. Aaaaeaiiy
i?aaei?cieiio aeicith 1ia/ea aaae o ii?aeiaii? c iaaeeeaiaioiciith
oa?ai??th (ianoa?i?aei? i?ioecaiaeuei?, aiaeueaaoeee, noaeeii? oa
na/ia?ii? i?aia?aoe) iiaeiia i?iaiaeeoeny /a?ac aeaiue, i?e
iaiao?aeiino? — 3 ?i?eoe??. O ?ac? a?aenooiino? iiceoeaiiai aoaeoo,
i?ney o?aoueiai aaaaeaiiy i?aaei?-cieiio, iiaeaeueoa ca?eueoaiiy
e?eueeino? i?ioeaaeo? iaaeioe?eueia.

5. E?eoaaiiy IOIO ie ?aeiiaiaeo?ii iaoe??ioai c ?aoeaeoi?iei neiae?iiii
o ii?aeiaii? c iaaeeeaiaioiciith oa?ai??th. Aeey aeinyaiaiiy no?eeiai
oa?aiaaoe/iiai aoaeoo iaiao?aeii i?iaiaeeoe ia iaioa 6 naain?a.

6. Oai?ei c ?aoeaeoi?iei neiae?iiii iieacaia i?iaaaeaiiy 10
naain?a ii?ii?iaiiy aae?e-iaiiiaei eaca?ii o ii?aeiaii? c
iaaeeeaiaioiciith ei?aeoe??th. Oai?ei c ei??ioeaaei neiae?iiii i?ney
aiaeiethiaaeueiiai aaaaeaiy i?aaei?cieiio ie ?aeiiaiaeo?ii 15 naain?a
ii?ii?iaiiy aae?e-iaiiiaei eaca?ii.

Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??.

1. Noaoeiiaa A.A. I?eiaiaiea onoaiiaee n io?eoeaoaeueiui aeaaeaieai ia
ieaeithth /anoue oaea iaoeeaioa aeey ea/aiey iiynie/ii-e?anooeiaiai
?aaeeeoeeoa // A?oea eeeie/aneie e yenia?eiai-oaeueiie iaaeeoeeiu
(i?ee.). — Aeiiaoee. — 1998. — O.7, ?1. — N. 73-77.

Noaoeiiaa A.A. Aeeaaiinoeea aeeneiaaiiuo iiynie/ii-e?anooeiauo
?aaeeeoeeoia iaoiaeii eiiiuethoa?iie oiiia?aoee // Aanoiee i?iaeai
aeieiaee e iaaeeoeeiu.- Iieoaaa-Oa?ueeia.-1997.- ?26.- N.11-17.

3. Noaoeiiaa A.A. Enneaaeiaaiea eiioiieiae/aneie ?aaeoeaiinoe o aieueiuo
n o?iie/aneeie iiynie/ii-e?anooeiauie ?aaeeeoeeoaie // Aanoiee i?iaeai
aeieiaee e iaaeeoeeiu. — Iieoaaa-Oa?ueeia.-1997.- ?29.- N.13-20.

4. Noaoeiiaa A.A. Aeeaaiinoe/aneay yooaeoeaiinoue eiiiuethoa?iie
oiiia?aoee i?e niiiaeeeiaaiiii iiynie/ii-e?anooeiaii ?aaeeeoeeoa //
Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu: Nai?iee noaoae.-
Aeiiaoee: Eaaaaeue.- 1997.- *.1. — N. 148.

5. Noaoeiiaa A.A. Yiaeiethiaaeueiia aaaaeaiea i?aaeiecieiia i?e ea/aiee
aeeneiaaiiiai ?aaeeeoeeoa // Aii?inu yenia?eiaioaeueiie e eeeie/aneie
iaaeeoeeiu: Nai?iee noaoae. — Aeiiaoee: Eaaaaeue. — 1997. -*.2. — N.
165-167.

6. Iiaeeaaneee TH.O., Noaoeiiaa A.A., Naeaciaaa N.A., I?ieiiaiei A.A.,
Oe?i/aiei A.I. Eniieueciaaiea aaeee-iaiiiaiai eaca?a a eiiieaeniie
oa?aiee niiiaeeeiaaiiiai iiynie/ii-e?anooeiaiai ?aaeeeoeeoa // Ieoaiiy
noaeiai? iaaeeoeeie oa aenia?oii? i?aeoeee: Ca. iaoe. i?aoeue.-
Aeiiaoeuee, 1998.- N. 103-104.

7. Iaca?aiei A.A., Naeaciaaa N.A., I?ieiiaiei A.A., Eieanieeia I.A.,
Aauaiei A.N., Noaoeiiaa A.A. Aeeiaieea eeeie/aneeo e
yeaeo?ioeceieiae/aneeo iieacaoaeae i?e ea/aiee niiaoiaaiiuo
aaaaoaoeaii-ninoaeenouo neiae?iiao // Iaeioi?ua i?iaeaiu nia?aiaiiie
oeceieiaee: Oac. aeiee. iaeanoiie eiioa?aioeee oeceieiaia.-Aeiiaoee,
1991.-N. 41.

8. Noaoeiiaa A.A. Eniieueciaaiea eiiiuethoa?iie oiiia?aoee aeey
aeeaaiinoeee aeeneiaaiiuo caaieaaaiee iicaiii/ieea // Oac. aeiee. VIII
iaeanoiie iao/iie eiioa?aioeee ii?oieiaia.- Aeiiaoee, 1991.- N. 250.

9. Noaoeiiaa A.A. Eiiieaeniia ea/aiea aieueiuo n aeeneiaaiiui
iiynie/ii-e?anooeiaui ?aaeeeoeeoii // Oac. aeiee. I iaeanoiie iao/iie
eiioa?aioeee ii?oieiaia. — Aeiiaoee, 1992.- N. 184.

10. Noaoeiiaa A.A. Caaeneiinoue eeeie/aneeo oi?i niiiaeeeiaaiiiai
iiynie/ii-e?anooeiaiai ?aaeeeoeeoa io oa?aeoa?a eciaiaiee a
aeaeaaoaeueiuo naaiaioao iicaiii/ieea // Oac. aeiee. I iaeanoiie iao/iie
eiioa?aioeee ii?oieiaia.- Aeiiaoee, 1992.- N. 183.

Aiioaoe?y

Noao?iiaa I.A. Iia? i?aeoiaee aei e?eoaaiiy niiiaeeeiaaiiiai
iiia?aeiai-e?eaeiaiai ?aaeeeoe?oo. — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
?c niaoe?aeueiino? 14.01.15 — ia?aia? oai?iae. — Ee?anueea iaaee/ia
aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie. Ee?a,
1999.

?iaioa i?enay/aia ieoaiiyi e?eoaaiiy oai?eo ia niiiaeeeiaaiiee
iiia?aeiai-e?eaeiaee ?aaeeeoe?o. ?ic?iaeaia iaoiaeeea e?eoaaiiy
aieueiaiai neiae?iio aiaeiethiaaeueiei aaaaeaiyi i?aaei?cieiio. Aea/aiee
?ioiiee noaoon ? i?iaaaeaia ei?aeoe?y eaaai?cieii o iaoe??io?a c
ei-??ioeaaei neiae?iiii. Aia?oa ?ic?iaeaiee iiaee o?c?ioa?aiaaoe/iee
iaoiae e?eoaaiiy o?ii?/iiai ?aaeeeoe?oo ia iniia? canoinoaaiiy
iaaaoeaiiai oeneo ia ieaeith iieiaeio o?ea iaoe??ioa. Aecia/ai?
iioeiaeuei? ?aaeeie e?eoaaiiy aae?e-iaiiiaei eaca?ii. I?iaaaeaia
ii??aiyeueia ioe?iea ??cieo iaoiae?a e?eoaaiiy. ?ic?iaeaiee ?
ai?iaiaaiee aeai?eoi e?eoaaiiy niiiaeeeiaaiiiai iiia?aeiai-e?eaeiaiai
?aaeeeoe?oo, yeee aeicaieea i?aeaeueoe aoaeoeai?noue e?eoaaiiy c 31,4%
aei 81,8% o oai?eo c ?aoeaeoi?iei ? aei 72,2% — c ei??ioeaaei
neiae?iiii.

Eeth/ia? neiaa: iiia?aeiai-e?eaeiaee ?aaeeeoe?o, inoaioiiae?ic,
eiina?aaoeaia e?eoaaiiy, aiaeiethiaaeueia aaaaeaiiy i?aaei?cieiio,
?ioiiei?aeoe?y.

Annotation

E.A. Statinova. New Approaches to Treatment of Lumbosacral
Radiculitis.-Manuscript.

The dissertation submitted for the Candidate of Sciences(Medicine)
Degree in speshiality 14.01.15-nervous diseases.- Kyiv Medical Academy
of Post-Graduated Education named after P. Shupyk. Health Ministry of
Uk-raine. Kyiv, 1999.

The work is developed to the problem of treating patients with
lumbosacral radiculitis. A method of treating algesic syndrome by the
endolumber administration of prednisolone has been developed. The immune
state of patients with reflex and radicular syndromes has been studied
and their levamisole correction conducted. A new physioterapeutic method
of treating chronic radiculitis based on the use of negative pressure
applied to the lower extremitis has been pionereed. Optimal therapeutic
regimens with a helium-neon laser application have been determinated. A
comparative assesment of various methods of treatment has been narried
out. A therapeutic algoritm has been developed which allowed to
raice to efficasy of treatment from 31,4% to 81,8% of patients with
reflex and to 72,2% — with radicular syndromes.

Eay wirds: lumbosacral radiculitis, osteochondrosis, therapeutic
treatment, endolumber administration, immunocorection.

Aiiioaoeey

Noaoeiiaa A.A. Iiaua iiaeoiaeu e ea/aieth niiiaeeeiaaiiiai
iiynie/ii-e?anooeiaiai ?aaeeeoeeoa. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.15- ia?aiua aieacie.- Eeaaneay iaaeeoeeineay
aeaaeaiey iineaaeeieiiiiai ia?aciaaiey ei. I.E. Ooieea IC Oe?aeiu. Eeaa,
1999.

?aaioa iinayuaia aeooaeueiie i?iaeaia nia?aiaiiie iaa?ieiaee — ea/aieth
aieueiuo niiiaeeei-aaiiui iiynie/ii-e?anooeiaui ?aaeeeoeeoii, eioi?ay
iniiauaaaony ia eco/aiee 148 aieueiuo iiynie/ii-e?anooeiaui
?aaeeeoeeoii, ec ieo ioae/ei — 130 (87,8%), aeaiuei — 18 (12,2%).
Iaoeeaiou auee ?ani?aaeaeaiu ia o?e a?oiiu, ia?aay n ?aoeaeoi?iui,
aoi?ay n ei?aoeiaui e o?aouey n ei?ao-eiai-ninoaeenoui neiae?iiaie.
Ianeaaeiaaiea aieueiuo i?iaiaeeeinue n iiiiuueth eaai?aoi?iuo,
?aioaaiieiae/aneeo, eiioiieiae/aneeo iaoiaeia, eiiiuethoa?iie oiiia?aoee
iicaiii/ieea, ?aiaacia?aoee, oeueo?acaoeiaie aeiiiea?ia?aoee,
oa?iia?aoee ieaeieo eiia/iinoae. Auyaeaiu ia?ooaiey eiioiiiai noaoona o
aieueiuo n ei?aoeiaui neiae?iiii: nieaeaiea aaniethoiiai e
ioiineoaeueiiai eiee/anoaa O-eeioioeeoia, ia?ooaiea niioiioaiey Oh/Os a
noi?iio Oh, nieaeaiea ooieoeeiiaeueiie aeoeaiinoe eeioioeeoia.
Eiioiieiae/aneee aeenaaeain aue aieaa au?aaeai o aieueiuo, eioi?ua
aeeeoaeueii no?aaeaee niiiaeeeiaaiiui iiynie/ii-e?anooeiaui
?aaeeeoeeoii. Aeey ii?aaeaeaiey iioeiaeueiiai ?aaeeia ea/aiey
iacia/aeenue ?acee/iua aeicu e noaiu i?aia?aoa. Iioeiaeueiie noaiie
ei??aeoeee ia?ooaiee eiioieoaoa o aieueiuo n ei?aoeiaui neiae?iiii
yaeyaony iacia/aiea eaaaieciea a eo?niaie aeica 600 ia ( 75ia /a?ac
aeaiue a oa/aiee aeaoo iaaeaeue). Iaie ia auyaeaia caaeneiinoue iaaeaeo
au?aaeaiiinoueth aieaaiai neiae?iia e eciaiaieyie eiioiieiae/aneeo
iieacaoaeae. ?ac?aaioaia iaoiaeeea ea/aiey aieaaiai neiae?iia o aieueiuo
n ei?aoeiaui neiae?ii NIE? yiaeiethiaaeueiui aaaaeaieai i?aaeiecieiia.
Iieacaieai e aeaiiiio iaoiaeo ea/aiey aue au?aaeaiiue aieaaie neiae?ii,
iaoneiaeaiiue caoyioaoeiny iaino?aieai o?iie/aneiai niiiaeeeiaaiiiai
iiynie/ii-e?anooeiaiai ?aaeeeoeeoa, o?oaeii iiaeaeathueeny
iaaeeeaiaioiciie ei??aeoeee. I?aeiouanoaii aeaiiiai niiniaa yaeyaony
iaiin?aaenoaaiiia aaaaeaiea i?aia?aoa a noaa?aoiieaeaeueiia
i?ino?ainoai, /oi iicaieyao aeiaeoueny aieaa noieeiai e au?aaeaiiiai
eeeie/aneiai yooaeoa. Iaoe enneaaeiaaiey iieacaee, /oi neaaeoao
iacia/aoue ia aieaa o?ao eiuaeoeee. Eco/aeanue yooaeoeaiinoue ?acee/iuo
noai ea/aiey aieueiuo niiiaeeeiaaiiui iiynie/ii-e?anooeiaui
?aaeeeoeeoii, iaoeeaiou auee ?acaeaeaiu ia o?e a?oiiu. A ia?aoth a?oiio
aioee iaoeeaiou, eioi?ua iieo/aee oieueei iaaeeeaiaioicioth oa?aieth, ai
aoi?oth — eioi?ui ia?aeeaeueii n iaaeeeaiaioiciie oa?aieae i?iaiaeeee
yieaeo?aeueiua aeieaaeu i?aaeiecieiiii e a o?aoueth — aieueiua, eioi?ui
ia?yaeo n iaaeeeaiaioiciie oa?aieae, iacia/aee yiaeiethiaaeueiia
aaaaeaiea i?aaeiecieiia. Iaeaieaa yooaeoeaiui auei ea/aiea aieueiuo a
o?aoueae a?oiia. Aia?aua ?ac?aaioai iiaue oeceioa-?aiaaoe/aneee iaoiae,
iniiaaiiue ia i?eiaiaiey io?eoeaoaeueiiai aeaaeaiey, i?eeiaeaiiiai ia
ieae-ithth iieiaeio oaea iaoeeaioa. Ea/aiea io?eoeaoaeueiui aeaaeaieai
iacia/aee 22 aieueiui n ?aoeae-oi?iui neiae?iiii. Aeeeoaeueiinoue
aieaaiai neiae?iia ninoaaeea io ianeieueeeo ianyoeaa aei 10 eao.
Ea/aaiua naainu i?iaiaeeee /a?ac aeaiue, anaai iacia/aeinue 8 naainia.
Aeey iauaeoeaecaoeee ninoiyiey iee?ioee?eoeyoeee auiieiyee
?aiaacia?aoeth ieaeieo eiia/iinoae aei e iinea ea/aiey. I?eiaiaiea
io?eoeaoaeueiiai aeaaeaiey ia ieaeithth iieiaeio oaea iaoeeaioa
iicaieeei iiauneoue yooaeoeaiinoue ea/aiey aieueiuo n ?aoeaeoi?iui
neiae?iiii. Ii?aaeaeaiu iioeiaeueiua ?aaeeiu ea/aiey aaeee-iaiiiaui
eaca?ii o aieueiuo n ?acee/iuie eeeie/aneeie neiae?iiaie
niiiaeeeiaaiiiai iiynie/ii-e?anooeiaiai ?aaeeeoeeoa. Eniieueciaaee
aaeee-iaiiiaue eaca? n aeeeiiie aieiu 0,63iei, auoiaeiie iiuiinoueth
5-10 iAo, yia?aaoe/aneie ieioiinoueth 0,1-0,5 Aeae/ni2, noia?iia a?aiy
aicaeaenoaey — 5-10 iei., io 10 aei 18 naainia ia eo?n. Aicaeaenoaiaaee
ia i?iaeoeeiiiua ciiu iia?aaeaeaiiuo iicaiieia, iaaeiicaiieiauo aeeneia
e ei?aoeia, iaeo/ay ia?aaa?oaa?aeueiua oi/ee e iiynie/ii-e?anooeiaoth
iaeanoue. Aeey ea/aiey aieueiuo n ?aoeaeoi?iui neiae?iiii neaaeoao
i?iaiaeeoue 10 naainia iaeo/aiey aaeee-iaiiiaui eaca?ii, a aeey aieueiuo
n ei?aoeiaui — 15. ?ac?aaioai e ai?iae?iaai aeai?eoi
aeeooa?aioee?iaaiiiai ea/aiey niiiaeeeiaaiiiai iiynie/ii-e?anooeiaiai
?aaeeeoeeoa. Ana aieueiua aia caaeneiinoe io eeeie/aneiai neiae?iia
aeieaeiu iieo/aoue iaaeeeaiaioicioth oa?aieth, aeeth/athuoth
ianoa?ieaeiua i?ioeaiainiaeeoaeueiua, ii/aaiiiua, aiaeueaaoeee e
ninoaeenoua i?aia-?aou. Iaoeeaioai n ?aoeaeoi?iui neiae?iiii
?aeiiaiaeoai i?iaiaeeoue oanoue naainia ea/aiey io?eoeaoaeueiui
aeaaeaieai, i?eeiaeaiiui ia ieaeithth iieiaeio oaea eee aeanyoue naainia
aaeee-iaiiiaiai eaca?a. O aieueiuo n ei?aoeiaui neiae?iiii ia oiia
iaaeeeaiaioiciie oa?aiee, ?aeiiaiaeoai iacia/aoue eiioiiei??aeoeeth
eaaaiecieii, yiaeiethiaaeueiia aaaaeaiea i?aaeiecieiia e iaeo/aiea
aaeee-iaiiiaui eaca?ii. Aiaae?aiea iiauo niiniaia e noai iicaieeei
iiauneoue yooae-oeaiinoue ea/aiey n 31,4% aei 81,8% o aieueiuo n
?aoeaeoi?iui e aei 72,2%- n ei?aoeiaui neiae-?iiii.

Eeth/aaua neiaa: iiynie/ii-e?anooeiaue ?aaeeeoeeo, inoaioiiae?ic,
eiina?aaoeaiia ea/aiea, yiaeiethiaaeueiia aaaaeaiea i?aaeiecieiia,
eiioiiei??aeoeey.

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