Aeaaeaiey iaaee/ieo iaoe oe?a?ie

?inoeooo oa?iaeieia?? oa oieneeieia??

Ia i?aaao ?oeiieno

AIAe???A Iaaei Aieiaeeie?iae/

OAeE 612.82:615.214.31.

IIIO?III? ?A*IAEIE ssE IIAeOEssOI?E OeAIO?AEUeII? AEOOAIAOA?A?*II?
NEIAIOE*II? IA?AAeA*?

14.03.05-Oa?iaeieia?y

AAOI?AOA?AO

Aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Ee?a 1999

Aeena?oaoe??th ? ?oeiien

?iaioo aeeiiaii o Aeiiaoeueeiio Aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I. Ai?ueeiai I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? AA?AIAOeUe ?ai?
?ai?aae/, Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani?
eaoaae?e oa?iaeieia??

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? A?iiia Eaii?ae
Ieaenaiae?iae/, ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie,
ea??aiee a?aeae?eo iae?ioa?iaeieia??;

aeieoi? iaaee/ieo iaoe, i?ioani? Iai/o? A?oae?e Eineiiae/,
Aeiai?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y, caa?aeoaa/ eaoaae?e
oa?iaeieia??

I?ia?aeia onoaiiaa: Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
i.Iaeana, eaoaae?a oa?iaeieia??

Caoeno a?aeaoaeaoueny 14 aeiaoiy 1999?. i 1500 aiaeei? ia can?aeaii?
niaoe?ae?ciaaiii? a/aii? ?aaee Ae 26.550.01 a ?inoeooo? oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie (252057, i. Ee?a, aoe. A. Iioue?, 14).

C aeena?oaoe??th iiaeia iciaeieoenue o a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeiea?? AII Oe?a?ie ca aae?anith: (252057, i. Ee?a,
aoe. A. Iioue?, 14).

Aaoi?aoa?ao ?ic?neaiee ”13” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao a?ieia?/ieo iaoe ?.A.Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca oaia??oiueiai /ano a?eueo?noue aeine?aeiee?a
?icaeyaea? iiio?iii? ?a/iaeie ye iae?iiaoaaie?/i? oea?aa?ii?ioaeoeai?
caniae, ye? oeyoii iioei?caoe?? iai?iieo i?ioean?a o ia?aiaeo oa
ae?aeueieo ee?oeiao iie?ioothoue ooieoe?iiaeueiee noai iiceo ?
iieaaoothoue iaa/aiiy, a oaeiae oi?ioaaiiy oa aeeo/aiiy iai cyoieo
ne?ae?a o ethaeeie ? oaa?ei (Ai?ii?ia O.A. 1991; Eiaaeaa A.E. 1990;
Heise G.A., 1987). Ii?yae c oeei aoei anoaiiaeaii, ui i??aoeaoai
iieaaooa neiaioe/io ia?aaea/o a iiceo, i?i ui na?ae/eoue ca?eueoaiiy
aiie?ooaee o?aineeicaeueieo a?aeiia?aeae, iaoiiaeaia eiai ae??th
(Giurgea C., Moyersoons F., 1978). Aea i?e?iaea i?yii? neiaioio?iiii?
ae?? iiio?ii?a aei 90-o ?ie?a ia aeine?aeaeoaaeanue. A 1990 – 1992 ??
yiiinuee? oa aia?eeainuee? aeine?aeieee aeiaaee, ui iaeei c aiaeia?a
iaea?eueo iioe?aii? iiio?iiii? ?a/iaeie i??aoeaoaia – ai??aoeaoai a
i?e?iiey?ieo eiioeaio?aoe?yo i?aeaeuo? oaiinaineoeai?noue
iinoneiaioe/ieo AI?A/ea?iaoieo ?aoeaioi??a (Ito I. et al., 1990; Lynch
G. et al., 1991). Oe? oaeoe aeacothoue ia iiaeeeao i?yio e ia?aeiio
neiaioio?iiio ae?th iiio?ii?a.

Aiaeii/an aoee noi?ioeueiaai? aeoiee uiaei ineoio?iiieo cania?a, aei
yeeo a?aeiinyoueny ? iiio?iii? caniae, ye aeinoa?e/ieo ? iaoaaie?/ieo
iiaeoeyoi??a ieanoe/ieo aeanoeainoae oeaio?aeueieo neiain?a (Eii?nna?ia
E.A., Aa?aiaoeue E.E. 1994).

O cayceo c oeei aenoaa?oueny a?iioaca, ca?aeii c yeith iiio?iii?
?a/iaeie iiaeooue aooe aeinoa?e/ieie ? iaoaaie?/ieie iiaeoeyoi?aie
iinoneiaioe/ieo aeooaiaoieo ?aoeaioi??a (A?), ye? aa?ooue o/anoue a
aaia?aoe?? CINI ? caaacia/othoue i?aeiae?iiio neiaioe/io ia?aaea/o. Naia
neiaioio?iiia ae?y iiio?ii?a aeicaiey? iiynieoe ?o caeaoi?noue
iioei?coaaoe iai cyoue ? iaa/aiiy o ?ioaeoieo oaa?ei, ?, c ?ioiai aieo,
aeaoe a?eueo iiai? oyaeaiiy uiaei i?e?iaee ?oiuei? iae?iiaoaaie?/ii?
ae??. E??i oiai, ?ic?iaea i?iaeaie ia?aeiii? neiaioio?iiii? ae??
iiio?ii?a iiaea noaoe oai?aoe/ith iniiaith aeey iiooeo oa?iaeieia?/ieo
?a/iaei c iioaioe?eiith aioeaiianoe/iith aeoeai?noth.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeaia ?iaioa
aeeiiaia a ?aieao ieaiiai? oaiaoeee IAe? eaoaae?e oa?iaeieia??
Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai IIC
Oe?a?ie “?ic?iaea i?eioeei?a noai?aiiy iiio?ii?a oa ?o eiia?iaoe?e ia
iniia? a?iioace i?i ineoioa?iaeieia?/i? ?a/iaeie ye iiaeoeyoi?e
aoaeoeaiino? i?aeiae?iiieo neiaioe/ieo ca’yce?a. Aea?aeaaiee
?a?no?aoe?eiee iiia? 0195V0001245.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei noai?aiiy ia iniia?
aenia?eiaioaeueieo oaeo?a a?iioace uiaei iiio?iiieo ?a/iaei ye
iaoaaie?/ieo iiaeoeyoi??a oaiinaineoea-iino? oeaio?aeueieo
iinoneiaioe/ieo aeooaiaoieo ?aoeaioi??a. Aeey aeinyaiaiiy aeacaii? iaoe
aoei iinoaaeaii oae? caaaeaiiy:

1.Aeine?aeaeaiiy aieeao iiio?ii?a ??cii? o?i?/ii? aoaeiae ia
iinoneiaioe/i? AI?A/ea?iaoi? ? IIAeA aeooaiaoi? ?aoeaioi?e.

2.Aea/eoe aieea iiio?ii?a ia ieanoe/i? aeanoeaino? oeaio?aeueieo
aeooaiaoa?a?/ieo neiain?a.

3.Ioe?ieoe cia/aiiy aieeao iiio?ii?a ia iinoneiaioe/i? aeooaiaoi?
?aoeaioi?e c oi/ee ci?o ?o iiaeoethth/i? ae?? ia ieanoe/i? aeanoeaino?
neiain?a.

4.Aeae?eeoe iae?iii? oa neiaioe/i? aoaeoe iiio?ii?a, ye? ni?iiiaei? aooe
?ioi?iaoeaieie e?eoa??yie aeai?o oa?iaeieia?/ieo ?a/iaei c iioaioe?eiith
iiio?iiiith aeoeai?noth.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa anoaiiaeaii, ui
i??aoeaoai o i?e?iiiey?ieo eiioeaio?aoe?yo oa ?io? aeine?aeaeai?
iiio?iii? caniae caeaoi? i?aeaeuoaaoe aioo??oiueiee?oeiio
eiioeaio?aoe?th Na2+ o i??aieaeieo iae?iiao ae?eyiee NA1 a?iieaiio ?
ca?ienoeo ee?oeiao coa/anoi? cae?ooee. Oeae aoaeo iiina?aaeeiaaiee
aeoeaaoe??th AOO caeaaeieo a?ee?a (iiaeeeai Gp) ? onoaa?ony aeaio?ieaiii
iao??th, yeee i?eai?/o? aea?eueiaiiy Na2+ ?c oeenoa?i
aiaeiieaciaoe/iiai ?aoeeoeoia. Aeiaaaeaii, ui ni?e/eiaia iiio?iiieie
?a/iaeiaie i?aeaeuaiiy aioo??oiueiiae?iiaeueii? eiioeaio?aoe?? Na2+
aeoeao? eaeueiiaeoe?i, Na2+/eaeueiiaeoe?icaeaaeio i?ioa?ie?iaco ?? ?
i?ioa?ie?iaco N, eio?? oinoi?eeththoue aioo??oiueiee?oeii? aeiiaie IIAeA
aeooaiaoieo ?aoeaioi??a ? AI?A/ea?iaoieo ?aoeaioi??a. Oinoi?eethaaiiy
?iiioi?ieo aeooaiaoieo ?aoeaioi??a (A?) ni?e/eiy? ca?eoaiiy ?oii?
oaiinaineoeaiino?. Aeyaeaii, ui caeaoi?noue iiio?iiieo ?a/iaei
iieaaooaaoe ?iaeoeoe?th ? ca?eueooaaoe o?eaae?noue IIAeA-caeaaeii? oa
IIAeA-iacaeaaeii? oi?i o?eaaei? iinooaiai?/ii? iioaioe?aoe?? neiaioe/ii?
ia?aaea/? coiiaeaia ia?aaaaeiei i?aeaeuaiiyi oaiinaineoeaiino?
AI?A/ea?iaoieo ?aoeaioi??a ? eeoa /anoeiai IIAeA aeooaiaoieo
?aoeaioi??a, ui ni?e/eieia ae??th iiio?iiieo ?a/iaei.Aia?oa anoaiiaeaii,
ui caeaaei?noue ae?? iiio?iiieo ?a/iaei a?ae ?o eiioeaio?aoe?? ia
ee?oeiiiio ??ai? iieno?ony e?eaith, ui ia? aecaiiiiiae?aio oi?io. A
iniia? aeno?aiaeueii? caeaaeiino? eiioeaio?aoe?y – aoaeo iiio?iiieo
?a/iaei eaaeeoue, iiaeeeai, aiii- oa aaoa?ieia?/ia aeanaineoecaoe?y
ae?eyiie niaoeeo?/iiai ca’ycoaaiiy iiio?iiieo ?a/iaei o iaia?aiao
ia?aiaeo ee?oei.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeyaeaiiy ee?oeiieo
iaoai?ci?a, ca aeiiiiiaith yeeo iiio?iii? ?a/iaeie i?aeneeththoue
a?aeiia?ae? ia?aiaeo ee?oei, iiina?aaeeiaai? aeoeaaoe??th IIAeA A? oa
AI?A/ea?iaoieo ?aoeaioi??a, noai?th? ?aoe?iiaeuei? ia?aaeoiiae aeey
eiia?iiaaiiai canoinoaaiiy e?ea?nueeeo ?a/iaei c iiio?iiiith
aeoeai?noueth o ?ic?aooieo ia oaiiiai iioaioe?eiaaiiai neia?a?cio.
Aeyaeaiiy ia i?aenoaa? ei?aeyoe?eiiai aiae?co iae?iiieo oa neiaioe/ieo
aoaeo?a, ni?e/eiaieo iiio?iiieie ?a/iaeiaie, eio?? cia/eii ei?aeththoue
c ?oiueith aioeaiianoe/iith ae??th, o aeine?aeao, iia’ycaieo c aea/aiiyi
iiaaae?iee, aea? ciiao ?aeiiaiaeoaaoe caeaoi?noue aeine?aeaeoaaiieo
?a/iaei i?aeneethaaoe a?aeiia?ae? ia?aiaeo ee?oei, iiina?aaeeiaai?
aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, ? ca?eueooaaoe o?eaae?noue
o?eaaei? iinooaoai?/ii? iioaioe?aoe?? (OIOI) neiaioe/ii? ia?aaea/? o
c??cao a?iieaiio a?ecoi?a ye i?iaiinoe/i? e?eoa??? aeey ne?ei?iaa
oa?iaeieia?/ieo ?a/iaei c iioaioe?eiith iiio?iiiith aeoeai?noth.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaaoa aeeiiaia naiino?eii.
Ca?? iaoa??aeo, inai?iiy iaoiae?a, i?iaaaeaiiy aeine?aeaeaiue,
aecia/aiiy iieaciee?a oa noaoenoe/ia ia?iaea ?acoeueoao?a cae?eniai?
iniaenoi, oai?/i ocaaaeueiaii io?eiai? ?acoeueoaoe, c?iaeaii caeeth/aiiy
oa noi?ioeueiaaii aeniiaee ? i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe?? ?acoeueoaoe iaoeiaeo aeine?aeaeaiue
aeiiia?aeaeenue ia neiiiceoi? – ia?aae? “Yenia?eiaioaeueia oa?iaeieia?y
– ee?i?oe?” (A?iieoey 1992), ia i?aeiaeanoi?e iaoeiai-i?aeoe/i?e
eiioa?aioe??, i?enay/aii?e 25-??/iiio tha?eath eaoaae?e oai?ia aooa,
ai?ea ? iina oaeoeueoaoo oaeineiiaeaiiy e?ea??a (Aeiiaoeuee 1994), ia
iaoeia?e eiioa?aioe?? “Aeooaeuei? i?iaeaie iaaeeoeeie Aeiiaano”
(Aeiiaoeuee 1996), ia XV c’?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa
(Aeiiaoeuee, 1998). Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 10 iaoeiaeo
?ia?o, c ieo — 3 noaoo? o oaoiaeo iaoeiaeo aeo?iaeao.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 152 noi??ieao
iaoeiiieno? aeeth/a? anooi, iaeyae e?oa?aoo?e, iien iaoa??ae?a ?
iaoiae?a aeine?aeaeaiiy, /ioe?e ?icae?ee ?acoeueoao?a aeine?aeaeaiiy c
iaaiai?aiiyi, caeeth/aiiy, aeniiaie, i?aeoe/i? ?aeiiaiaeaoe??, nienie
aeei?enoaieo aeaea?ae. A?ae?ia?ao?y i?noeoue 170 iaeiaioaaiue, a oiio
/ene? ca?oa?aeieo aaoi??a – 149. ?iaioa i?noeoue 13 oaaeeoeue, 19
iaethie?a.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeine?aee i?iaiaeeeenue ia
iioiiae?iiao ?cieueiaaiiai nieiiiai iiceo aeaa oa ia ?cieueiaaieo
ooieoe?iioth/eo c??cao a?iieaiio uo??a.

Aeey i?aeo?eioaaiiy ?iiiiai aiiainoaco ? aeeaeaiiy i?aia?aoe nieiiiai
iiceo aeaa oa c??ce a?iieaiio uo??a noia?oocoaaee nieueiaei ?ic/eiii
noaiaea?oiiai ?iiiiai neeaaeo (Eiienna?ia E.A., Aa?aiaoe E.E.
1989,1990). Aeey i?ae?eiee noaeino? aaciaiai neeaaeo na?aaeiaeua
aa?oaaee aaciaith noi?ooth, yea iaea o nia? 95% eenith ? 5% aoaeaeeneiai
aaco. Oaiia?aoo?a ?ic/eio ?aaoethaaeany oa?iinoaoii ? a aenia?eiaio? ia
c??cao a?iieaiio i?aeo?eioaaeany o iaaeao 30-32 N, a a aenia?eiaio? ia
nieiiiio iiceo noaiiaeea 18 N. Ia?aae aeeiiaiiyi aeine?aeo c??ce
i?ioiaeeee ia??iae aaeaioaoe?? aei nieueiaiai na?aaeiaeua i?ioyaii
aiaeeie.

O ia?o?e na??? aeine?ae?a iiae?aciaiiy iioiiae?ii?a cae?enithaaee aeaiia
oeyoaie. Ia?oee niin?a aoa oaeee: /a?ac i?e?ii?iaoeo, e?i/ee yei?
iii?uaee iiaeeco (10-30 iei) a?ae e?i/eea a?aea?aeiiai i?e?iaeaeo?iaea,
i?ae oeneii i?aeaiaeeee L-ania?aaeiiao (AE) e L-aeooai?iiao (AE) eeneioe
a eiioeaio?aoe?? 30 iI. Oaeiae aeine?aeaeoaaee CINI iioiiae?ii?a,
ni?e/eiai? aeaeo?e/iei iiae?aciaiiyi, ui eiai caaaeaaaee a ae?eyioe?
aei?naeueieo ei??ioe?a nieiiiai iiceo, a?/ieo noiai?a ? ?aoeeoey?ii?
oi?iaoe?? aeiaaanoiai iiceo (AeE-CINI). Noeioeyoe?th cae?enithaaee
i?yiieooieie ?iioeuenaie no?oio iaaeii?iaiai? aaee/eie o?eaae?noth 0,1
in, /anoioith 0,1-0,2 Aoe. Aeine?aee aeeiioaaeenue ia iioiiae?iiao n
iaia?aiiei iioaioe?aeii ia iaio ye -60 iA, ui nooo?ai ia ci?ithaaany
i?ioyaii 2-3 aiaeei. Iaia?aiiee iioaioe?ae iioiiae?ii?a a?aeaiaeeee ca
aeiiiiiaith neeyieo i?e?iaeaeo?iae?a, caiiaiaieo ?ic/eiii ENl a
eiioeaio?aoe?? 3 iiieue/e.

Aeaeo?e/io noeioeyoe?th c??c?a a?iieaiio uo??a cae?enithaaee
i?yiieooieie ?iioeuenaie no?oio iaaeii?iaiai? aaee/eie o?eaae?noth 0,1
in, /anoioith 0,1-0,2 Aoe ca aeiiiiiaith a?iiey?ieo i?o?iiiaeo
aeaeo?iae?a ae?aiao?ii 0,08 ii c a?aenoaiith i?ae aeaeo?iaeaie 0,05 ii.
Iiae?aciaiiy caaaeaaaee a ae?eyieao: eieaoa?aeae Oaooa?a a ?aae?aeueiiio
oa?? NA1, o?eona coa/anoi? cae?ooee, aea i?ioiaeyoue aieieia
ia?oi?aioiiai oeyoo, iieaeoey?iiai oa?o NA3, aea i?ioiaeyoue iioiaeaei?
aieieia, ui eaeooue a?ae ca?ienoeo ee?oei coa/anoi? cae?ooee aei
i?ieneiaeueieo ae?eyiie aeaiae?eo?a i??ai?aeieo iae?ii?a NA3.

O ae?oa?e na??? aeine?ae?a ?a?no?oaaee iiioeyoe?ei? (i) CINI i??ai?aeieo
iae?ii?a ?aae?aeueiiai oa?o ae?eyiee NA1 ? iae?ii?a coa/anoi? cae?ooee
(ICC) a?iieaiio. A?aeaaaeaiiy iCINI cae?enithaaeinue a?ae ai?eaeueieo
aeaiae?eo?a ia a?aenoai? 200-300 iei a?ae oa?o i??ai?aeieo iae?ii?a ca
aeiiiiiaith neeyieo i?e?iaeaeo?iae?a, caiiaiaieo ?cioii?/iei ?ic/eiii
oei?eaea iao??th c ii??ii e?i/eea 5-10 iIi.

?a?no?iaai? iioaioe?aee aoee ioeeo?iaai? ca aeiiiiiaith 10-?ic?yaeiiai
AOeI c /anoioith 20eAoe, ia?iaeai? ia ia?niiaeueiiio eiiicthoa?? IBM
?N/AO 386 ? o?eniaai? ia aio/eeo iaai?oieo aeeneao.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Iiaeoethth/ee aieea iiio?ii?a ia iinoneiaioe/i? IIAeA A?.

I?e noia?ooc?? i?aia?aoo nieiiiai iiceo nieueiaei ?ic/eiii, ui i?noea
aeine?aeaeoaai? iiio?iie (i??aoeaoai-100 ieI, ao?i?cie-100 ieI,
aeeiaoeeai?iiaoaiie (AeIAA) -1000 ieI ? ea?aaoeaoai-30 ieI),
niinoa??aaee ca?eueoaiiy aiie?ooaee i?ci?o eiiiiiaio?a AeE-CINI, a
oaeiae aiie?ooaee a?aeiia?aeae, ni?e/eiaieo AE (oaae. 1).

A oiiaao aeieaaee ?iiieo eaiae?a IIAeA A? eaoai?iii aai ?iiaie iaai?th
iiio?iii? ?a/iaeie ia aieeaathoue ia aeaiiey?ecaoe?ei? a?aeiia?ae?,
ni?e/eiai? ae??th AE, ? ia caeeoeia? eiiiiiaioe iie?neiaioe/ieo
AeE-CINI.

Iia?eueiee ?icaeoie aoaeoo iiio?iiieo ?a/iaei ? eiai caa?aaeaiiy i?ney
aeaeaeaiiy ?o ?c ia?ooc?eiiai na?aaeiaeua aea? i?aenoaao aeoiaoe i?i
o/anoue a ?aae?caoe?? iioaioe?thth/iai aieeao iiio?ii?a aoi?eiieo
iina?aaeiee?a oa aeoeaiaaieo aoi?eiieie iina?aaeieeaie i?ioa?ie?iac.
Aeey ia?aa??ee oeueiai i?eiouaiiy aoei aea/aii aieea ?ia?a?oi??a
i?ioa?ie?iace A (aooaieae 100 ieI), eaeueiiaeoe?io (o?eooi?ia?acei 1
ieI), i?ioa?ie?iace N (iie?i?eneio A noeueoao 250 ieI) ia aoaeoe
iiio?ii?a. Ia oe? noia?ooc?? nieiiiai iiceo aooai?aeii a?aei?/aee iaeaea
oe?eeiaeoa i?eai?/aiiy iioaioe?thth/iai aieeao ao?i?cieo ? ciaiueoaiiy
iioaioe?thth/iai aieeao i??aoeaoaio ia aeine?aeaeoaai? a?aeiia?ae?
iioiiae?ii?a iacia/ii, aea noaoenoe/ii aeinoia??ii ciaiooaaany (oaae.
1). A oiiaao aeieaaee eaeueiiaeoe?io a?aei?/aee ?noioia ciaioaiiy
iioaioe?thth/iai aieeao AeIAA ia aeine?aeaeoaai? a?aeiia?ae?
iioiiae?ii?a. ?ia?aoaaiiy Na2+/ae?aoeeeae?oea?ei-noeioeueiaaii?
i?ioa?ie?iace N iie?i?eneiii A noeueoaoii i?ecaiaeeei aei oe?eeiaeoiai
i?eai?/aiiy iioaioe?thth/iai aieeao ea?aaoeaoaio ia ni?e/eiai? AE
aeaiiey?ecaoe?ei? a?aeiia?ae? ? AeE-CINI iioiiae?ii?a, ia aieeaath/e ia
iioaioe?thth/? aoaeoe ?ioeo iiio?iiieo ?a/iaei (oaae. 1).

Oaaeeoey 1.

Aieea ?ia?a?oi??a i?ioa?ie?iac oa eaeueiiaeoe?io ia iaoiiaeaiee
iiio?iiaie i?e??no aiie?ooae CINI, ni?e/eiaieo aie?eaoe??th
L-ania?aa?iiai? eeneioe (AE) oa noeioeyoe??th aei?naeueieo ei??ioe?a
(AeE-AINI) a?aeiia?aeae iioiiae?ii?a

Iiio?iii? ?a/iaeieEiioeaio?aoe?y (ieI/e)Ci?iaiiy aiie?ooae CINI ia oii?
ae?? ??cieo ?ia?a?oi??a i?ioa?ie?iac e eaeueiiaeoe?io (ISo*t) a % e
aeo?aeii?Eiio?ieueAooai?ae

100 ieI/eO?eooi?-

Ia?acei

1 ieI/eIie?i?eneio A noeueoao

250
ieI/eAeE-AINIAEAeE-AINIAEAeE-AINIAEAeE-AINIAEI??aoeaoai100127,55,5133,55
,8113,52,2111,52,4129,04,7129,54,3125,0
4,6131,04,9Ao?i?cie100132,53,7139,03,9104,52,2107,52,1128,53,9135,54,113
3,5
3,8132,03,6AeIAA1000148,04,2145,54,3138,55,5135,95,8109,52,3108,52,4150,
0
4,4144,04,2Ea?aaoeaoai30135,04,6142,54,9133,04,0145,04,6127,04,1139,04,4
107,0 2,2109,52,3*- aaee/eie noaoenoe/ii aeinoia??ii a?aei?ii? a?ae
eiio?ieth i?e ?=0,05

Oaeei /eiii aioeaiianoe/ia ae?y ao?i?cieo ? i??aoeaoaio iiaeeeai
iia’ycaia c oeAIO-caeaaeiei oinoi?eethaaiiyi IIAeA
?aoeaioi?ii-eaiaeueiiai eiiieaeno. Ae?y AeIAA ? ea?aaoeaoaio iia’ycaia c
oinoi?eethaaiiyi IIAeA A? ca aeiiiiiaith Na2+-eaeueiiaeoe?icaeaaeii?
i?ioa?ie?iace II ? i?ioa?ie?iace N a?aeiia?aeii.

O ae?oa?e na??? aeine?ae?a a yeino? iiaeae? aeey aeine?aeaeaiiy
a?aeiia?aeae iae?ii?a a?iieaiio uo??a, iiina?aaeeiaaieo aeoeaaoe??th
IIAeA A?, aoei aeei?enoaii ei?ioeioa?i?iiao iioaioe?aoe?th iCINI
i??ai?aeieo iae?ii?a ae?eyiee NA1, ni?e/eiaieo aeaeo?e/iith
noeioeyoe??th eieaoa?aeae Oaooa?a, ui aoea ?iaeoeiaaia 2-o oaeeeiiith
aie?eaoe??th IIAeA (120 ieI).

Aeine?aeaeoaai? iiio?iie ii-??ciiio aieeaaee ia iioaioe?thth/o ae?th
IIAeA ia neiaioe/io ia?aaea/o. Ia oe? iiia?aaeiuei? ae?? i?ioyaii 15
oaeeei ia c??ce aeiieaiio i??aoeaoaio (100 ieI) niinoa??aaee noaoenoe/ii
iaaeinoia??io oaiaeaioe?th aei ca?eueoaiiy iioaioe?thth/iai aieeao IIAeA
ia aiie?ooaeo iCINI i??aieaeieo iae?ii?a. Ia oe? aieeao ?ioeo iiio?ii?a
IIAeA ni?e/eiya aeinoia??ii a?eueoa c?inoaiiy aiie?ooaee iCINI o
ii??aiyii? c eiio?ieai (oaae. 2).

Iiio?iii? ?a/iaeie i?ecaiaeeee aei ca?eueoaiiy aiie?ooaee iCINI
i??aieaeieo iae?ii?a ae?eyiee NA1, ni?e/eiaieo aeaeo?e/iith
noeioeyoe??th eieaoa?aeae Oaooa?a (oaae. 2).

A oiiaao aeieaaee IIAeA A? iioaioe?thth/ee aieea IIAeA ia ?icaeaaany, a
iioaioe?thth/ee aieea iiio?ii?a ia aiie?ooaeo iCINI, ni?e/eiaieo
aeaeo?e/iith noeioeyoe??th eieeaoa?aeae Oaooa?a, ia ci?ithaaany.

Eia?/ii i?eionoeoe, ui ?ia?a?oi?e eaeueiiaeoe?io ? i?ioa?ie?iac iiaeooue
ii?oooaaoe ooieoe?th IIAeA A? ? a a?iieaii?.

Oaaeeoey 2.

Aieea iiio?iiieo ?a/iaei ia aiie?ooaeo iCINI i??ai?aeieo iae?ii?a
ae?eyiee NA1 a?iieaiio e ni?e/eiaio IIAeA ?o ei?ioeio?eaaeo
iioaioe?aoe?th

Iiio?iii? ?a/iaeieEiioeaio?aoe?y (ieI)Ci?iaiiy aiie?ooaee iAINI (ISo*t)
a % e enoiaeiieO a?aenooiino? IIAeAIa oe? ae??

120 ieI IIAeAAieea IIAeA ia oe? ae?? eaoai?io

(30
ieI)Eiio?ieue100125,75,3103,32,2I??aoeaoai100105,12,2136,26,9105,41,7Ao?
i?cie100122,35,6168,410,3124,64,4Iiiaeooee20114,53,3176,416,2115,33,9Ea?
aaoeaoai30112,73,1161,512,2113,43,2*- aaee/eie noaoenoe/ii aeinoia??ii
a?aei?ii? a?ae eiio?ieth i?e ?=0,05

Ia oe? ae?? ?ia?a?oi??a a?aeaoaaeiny ci?iaiiy iioaioe?thth/iai aieeao
ao?i?cieo, iiiaeooeeo ? ea?aaoeaoaio ia ni?e/eiaio IIAeA iioaioe?aoe?th
neiaioe/ii? ia?aaea/?. Ia oe? aeieaaee i?ioa?ie?iace A aooai?aeii
a?aei?/aee cieaeaiiy iioaioe?thth/iai aieeao ao?i?cieo ia iioaioe?aoe?th
neiaioe/ii? ia?aaea/?. Ia aoaeoe iiiaeooeeo ? ea?aaoeaoaio aooai?ae ia
aieeaaa (oaae. 2). Ae?y ia c??ce o?eooi?ia?aceio ? iie?i?eneio A
noeueoaoo i?ecaiaeeea aei cia/iiai ineaaeaiiy aieeao an?o iiio?iiieo
?a/iaei ia ni?e/eithaaio IIAeA ei?ioeioa?i?iiao iioaioe?aoe?th iCINI
i??ai?aeieo iae?ii?a (oaae. 2.).

I?ioa ae?y i??aoeaoaia, a oaeiae ?ia?a?oi??a eaeueiiaeoe?io ?
i?ioa?ie?iace N ia IIAeA A? a ni?iaeueieo iioiiae?iiao aeaa ?
i??ai?aeieo iae?iiao a?iieaiio uo??a aeaui ?ic??ciyeanue. Oe?
a?aei?iiino? iiaeooue aooe iane?aeeii iaiaeiaeiai? ii?oiooieoe?iiaeueii?
i?aai?caoe?? IIAeA A? i??ai?aeieo iae?ii?a a?iieaiio ? ni?iaeueieo
iioiiae?ii?a. E??i oiai, o oeeo aeaio oei?a iae?ii?a ae?eyiee
niaoeeo?/iiai ca’ycoaaiiy iiio?ii?a ? IIAeA A? iiaeooue iaoe ??cio
eieae?caoe?th.

Iiaeoethth/ee aieea iiio?ii?a ia iinoneiaioe/i? AI?A/ea?iaoi?
?aoeaioi?e.

Aeine?aeaeaiiy aieeao iiio?ii?a ia a?aeiia?ae? iae?ii?a, iiin?aaeeiiaai?
aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, i?iaiaeeee ia iCINI ca?ienoeo
iae?ii?a coa/anoi? caeaeie (ICC), ye? aeieeathoue i?e aeaeo?e/i?e
noeioeyoe?? ia?oi?aioiiai oeyoo.

A?aenooi?noue aieeao iiio?ii?a ia aaee/eio ia?iiai iieaaoaiiy ?
caa?aaeaiiy ?o ae?? ca oiia aeieaaee neiaioe/ii? i?aaea/? na?ae/eoue, ui
iiio?iii? ?a/iaeie ia aieeaathoue ia i?aneiaioe/ia aea?eueiaiiy
aeooaiaoo.

Ia oe? ae?? ?ia?a?oi??a aoai?eaooeeeeace (iaoeeaiiaee nei?e 50 ieI),
eaeueiiaeoe?io (niieoea W-7, 10 ieI), i?ioa?ie?iace A (aooai?ae 100 ieI)
? i?ioa?ie?iace (iie?i?eneio A noeueoao 100 ieI) aiie?ooaea iCINI ICC,
ni?e/eiaieo aeaeo?e/iith noeioeyoe??th ia?oi?aioiiai oeyoo, ia
ci?ithaaeany. I?ioa ia oe? ae?? ?ia?a?oi?a eaeueiiaeoe?io iioaioe?thth/a
ae?y iiio?ii?a ia ?icaeaaeany (oaae. 3). ?ia?aoaaiiy i?ioa?ie?iace N
ni?e/eiyei niaoeeo?/io aeai?an?th aoaeo?a aeine?aeaeoaaieo iiio?iiieo
?a/iaei (oaae. 3).

Oaaeeoey 3.

Aieea ?ia?a?oi??a i?ioa?ie?iac, aoai?eaooeeeeace ? eaeueiiaeoe?io ia
aoaeoe iiio?iiieo ?a/iaei.

Iiio?iii? ?a/iaeieEiioeaio?aoe?y (ieI)A?aeiini? ci?ie iCINI iae?ii?a a %
aei aeo?aeii?, (ISo*t)O a?aenooiino? ?ia?a?oi??aIa oe? iiia?aaeiuei?
ae?? i?ioyaii 30 oaeeeiAooaieaeo (100 ieI)Iaoeeaii-aiai neiueiai (50
ieI)W-7

(10 ieI)Iie?i?eneio A noeueoao

(100
ieI)I??aoeaoai60126.43,7127.36,0126.85,0103.35,9*88.314,2*Ao?i?cie30140.
212,9141.324,4141.09,8102.45,7*44.214,9*Ea?aaoeaoai6145.916,3153.613,515
3.217,1106.27,2*36.716,6*Iiiaeooee4156.014,2151.617,8149.919,9104.37,7*5
5.311,5** — aaee/eie noaoenoe/anii aeinoia??ii a?aei?ii? a?ae eiio?ieth
i?e ?<0,05 Ia iniia? oiai, ui ?ia?a?oi? eaeueiiaeoe?io i?eai?/o? aoaeoe on?o iiio?iiieo ?a/iaei, ia aieeaath/e i?e oeueiio aaciina?aaeiuei ia aiie?ooaeo iCINI, iiaeia i?eionoeoe, ui iioaioe?thth/ee aieea iiio?ii?a ia a?aeiia?ae? ICC, iiina?aaeeiaai? aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, coiiaeaiee i?aeaeuaiiyi aioo??oiuei-iae?iiaeueii? eiioeaio?aoe?? Na2+ oa aeoeaaoe??th aenieiao?iiiai Na-ca’ycoth/iai a?eea eaeueiiaeoe?io, c ianooiiith aeoeaaoe??th inoaii?i oa?iaioo Na-eaeueiiaeoe?icaeaaeii? i?ioa?ie?iace II. Aeey aecia/aiiy iiaeeeaiai aeaea?aea i?aeaeuaiiy Na2+ aea/aee ae?th ia aoaeoe iiio?ii?a ?a/iaei, ye? ii-??ciiio aieeaathoue ia iaoaaie?ci eaeueoe?th o ia?aia?e ee?oei?. Iioaioe?thth/ee aieea iiio?iiieo ?a/iaei ci?ithaaany o?eueee ia oe? ae?? ?a/iaei, ye? aieeaathoue ia aea?eueiaiiy Na2+ c aioo??oiueiee?oeiieo aeaii (oaae. 4). sse ia oe? aeieaaee eao?iiieo eaiae?a IIAeA A? eaoai?iii, oae ? a oiiaao aeieoaaiiy iioaioe?aecaeaaeieo Na2+-eaiae?a, (iecueeiii?iaiaeo ? aenieiii?iaiaeo) ?iiaie i?eaeth ? i?oaaeei?iii a?aeiia?aeii, iioaioe?thth/ee aieea iiio?ii?a ia a?aeiia?ae? iae?ii?a coa/anoi? caeaeie a?iieaiio, iiina?aaeeiaai? AI?A/ea?iaoieie ?aoeaioi?aie, ia ci?ithaaany (oaae. 4). Oaaeeoey 4. Aieea ?a/iaei, ye? aieeaathoue ia o?ainii?o ?ii?a Na2+, ia aoaeoe aeine?aeaeoaaieo iiio?iiieo ?a/iaei. Iiio?iii? ?a/iaeieEiioeaio?aoe?y (ieI)A?aeiini? ci?ie aiie?ooaee iCINI a % aei aeo?aeii?, (ISo*t)A a?aenooi?noue ?a/iaeiIa oe? iiia?aaeiuei? ae?? i?ioyaii 30 oaeeeiEaoai?ia (30 ieI)I?eaeth oei??aeo (30 ieI)I?oiaaiaaeaoo iao??y (0.3 ieI)Aeaio?ieaio iao??y (20 ieI)I?oaaeei?io (10 ieI)Ie?aoeaoai60126.43,7120.46,7118.77,6142.28,8104.010,3*122.23,1Ao?i?c ie30140.212,9147.713,4149.313,7164.913,1115.78,8*137.610,7Ea?aaoeaoai614 5.916,3152.415,7147.715,8175.115,2120.410,7*147.811,4Iiiaeooee4156.014,2 150.315,4155.415,7182.416,1114.37,7*150.712,2*- aaee/eie noaoenoe/ii a??ia?aeii a?aei?ii? a?ae eiio?ieth i?e ?<0, 05 Noeoii?noue oeeo aeaieo cana?ae/oa, ui a iniia? ni?e/eiaiiai i?e?iiiey?ieie eiioeaio?aoe?yie i??aoeaoaio oa ?ioeie aeine?aeaeoaaieie iiio?iiieie ?a/iaeiaie i?aeaeuaiiy oaiinaineoeaiino? AI?A/ea?iaoieo ?aoeaioi??a eaaeeoue i?aeaeuaiiy aioo??oiueiee?oeiii? eiioeaio?aoe?? Na2+ aiane?aeie aea?eueiaiiy eiai c aioo??oiueiee?oeiieo noiaeu. Aiaeii/an aeuacaaaeai? aeine?aeaeaiiy aacothoueny ia i?eiouaii?, ui iiio?iie iaaiei /eiii aeoeaothoue niieo/aio c AOO-caeaaeieie a?eeaie oinoie?iaco N, ine?eueee ?oi? aoaeoe iiaeoeththoueny ?a/iaeiaie, ye? aieeaathoue ia /ooeea? aei ?iiceoieiie?oinoao?a aioo??oiueiee?oeii? aeaii Na2+ (oaae. 5). Aeey i?aeoaa?aeaeaiiy oeueiai i?eiouaiiy i?iaaaeaii na??th aeine?ae?a c ?a/iaeiaie, ye? ii-??ciiio aca?iiae?thoue c AOO-caeaaeieie a?eeaie. Cie?aia, aeei?enoiaoaaee ooi?eae aethi?i?th oa iacaoii, ye? aeoeaothoue iaia?aii? AOOcaeaaei? a?eee, a oaeiae e?o?th noeueoao, eio?ee ii?ooo? ieanoe/i? aeanoeaino? neiain?a o a?iieaii? oa iaino??aooi?. Ca oiia aeoeaaoe?? AOOcaeaaeieo a?ee?a ooi?eaeii aethi?i?th aai iacaoiiii ia niinoa??aaee iioaioe?thth/iai aoaeoo iiio?iiieo ?a/iaei. Ia oe? noia?ooc?? c??c?a nieueiaei ?ic/eiii, ui i?noea e?o?th noeueoao o eiioeaio?aoe?? 2iI, iioaioe?thth/ee aieea iiio?ii?a aeyaeyany iaioa o ii??aiyii? c ?oiueith ae??th a aace?o??aiio na?aaeiaeu?. Aeei?enoaiiy iiio?iiieo ?a/iaei ia oe? a?eueo aeniei? eiioeaio?aoe?? e?o?th noeueoaoo (20 iI) iaei iane?aeeii a?eueo /?oea cieaeaiiy ?o iioaioe?thth/iai aieeao. A??ia?aeii, ui i??aoeaoai a noai?e?iiey?ieo eiioeaio?aoe?yo oa ?io? aeine?aeaeoaai? iiio?iie ca aeiiiiiaith AOOcaeaaeieo a?ee?a i?aeneeththoue a?ae?ie?c oinoi?iiceoeae?a ? ni?eythoue iaeiie/aiith a iae?ii? aoi?eiieo iina?aaeiee?a Na2+ oa ae?aoeeeae?oea?eio, ye?, o naith /a?ao, aeoeaothoue i?ioa?ie?iaco N ? eaeueiiaeoe?icaeaaeio i?ioa?ie?iaco II. Inoaii? oinoi?eeththoue eaiaeuei? aeiiaie AI?A/ea?iaoieo ?aoeaioi??a, aiane?aeie /iai ciaioo?oueny ?o aeanaineoecaoe?y ? ca?eueoo?oueny aiie?ooaea o?ainiaia?aiieo no?oi?a, ui eaaeaoue a iniia? iiiineiaioe/ieo CINI, ye? caaacia/othoue i?aeiae?iii? ca'ycee. Iiaeoethth/ee aieea iiio?ii?a ia aeooaiaoa?ae/io neiaioe/io ia?aaea/o. Ianooiiei e?ieii o aeine?aeaeaii? aieeao iiio?ii?a ia oeaio?aeueio aeooaiaoa?ae/io neiaioe/io ia?aaea/o aoei aea/aiiy aieeao iiio?ii?a ia oaiiiai o?eaaei? iinooaoai?/ii? iioaioe?aoe?? (OIOI) neiaioe/ii? ia?aaea/?. Aeine?aeaeaii aieea iiio?iiieo ?a/iaei ia on? oi?ie OIOI. sse iiaeaeue aeey aeine?aeaeaiiy IIAeA-caeaaeii? oi?ie OIOI neiaioe/ii? ia?aaea/? aeei?enoiaoaaee OIOI, ui aeieeaea a neiaioe/i?e nenoai? ia?oi?aioiee oeyo - ca?ieno? ee?oeie coa/anoi? caeaeie. ?a?no?oaaee iCINI iae?ii?a coa/anoi? caeaeie, ui ni?e/eiythoueny iaae - ? i?aeii?iaiaith aeniei/anoioiith oaoai?/iith noeioeyoe??th ia?oi?aioiiai oeyoo. I?e aeei?enoaii? iaeneiaeueieo ia?aiao??a noeioeyoe?? iiio?iii? ?a/iaeie nooo?ai ia aieeaaee ia aeni?an?th OIOI neiaioe/ii? ia?aaea/?. I?e ciaioaii? ?ioaineaiino? oaoai?/ieo noeioe?a aei ??aiy noeioe?a, ui ni?e/eiythoue iCINI ca?ienoeo ee?oei coa/anoi? caeaeie, oaeiae niinoa??aaee ?icaeoie OIOI neiaioe/ii? ia?aaea/?. Aiie?ooaea iCINI ca?ienoeo iae?ii?a coa/anoi? caeaeie c?inoaea iaeaea ia 50% ia 30 oaeeei? ? iiaa?oaeany aei aeo?aeieo aaee/ei /a?ac 67.54,3 oaeeei. Ae?y iiio?iiieo ?a/iaei ca oiia iaeneiaeueii? iaaeii?iaiai? oaoai?/ii? noeioeyoe?? ni?e/eiyeany aei ca?eueoaiiy o?eaaeino? OIOI neiaioe/ii? ia?aaea/? ia 15,52,3, 45,54,7, 72,44,8 ? 88,79,2 oaeeei aeey i??aoeaoaio, ao?i?cieo, iiiaeooeeo ? ea?aaoeaoaio a?aeiia?aeii.Ia oe? aeei?enoaiiy iiio?iiieo ?a/iaei ca oiia i?aeii?iaiai? noeioeyoe?? niinoa??aaee ?icaeoie OIOI neiaioe/ii? ia?aaea/?. Aeine?aeaeaiiy aieeao iiio?iiieo ?a/iaei ia IIAeAiacaeaaeio oi?io OIOI neiaioe/ii? ia?aaea/? i?iaiaeeee ia neiaioe/i?e iiaeae?: iioiiiae?ai? aieieia-aeaiae?eoe i??ai?aeieo iae?ii?a ae?eyiee NA3 a?iieaiio. On? aeine?aeaeoaai? iiio?iii? ?a/iaeie ca?eueooaaee o?eaae?noue OIOI, a oaeiae ni?e/eiyee ca?eueoaiiy aiie?ooaee IN ii??aiyii c eiio?ieueiith yeni?an??th OIOI o oe?e neiaioe/i?e nenoai?. I?e/iio oea aoei iaea?eueo i?eoaiaiii iiiaeooeeo ? ea?aaoeaoaio, ? i?i?iaeueii - i??aoeaoaio. Aeine?aeaeoaai? iiio?iii? ?a/iaeie o neiainao i??ai?aeii? ae?eyiee NA3 iieaaoothoue ?iaeoeoe?th OIOI neiaioe/ii? ia?aaea/? i?e oaoai?/i?e noeioeyoe?? iioiiiae?aieo aieieii ?iioeuenaie i?aeii?iaiai? aaee/eie, ye? o a?aenooiino? iiia?aaeiuei? ae?? iiio?ii?a ia caeaoi? ni?e/eiyoe o?eaaeo iioaioe?aoe?th neiaioe/ii? ia?aaea/?. sse neiaioe/io iiaeaeue aeey aeine?aeaeaiiy iecueei/anoioii? oi?ie OIOI neiaioe/ii? ia?aaea/? aeei?enoiaoaaee neiaine, ooai?ai? aeaiae?eoaie i??ai?aeieo iae?ii?a ae?eyiee NA1 ? eieaoa?aeyie Oaooa?a. Eieaoa?ae? Oaooa?a iiae?acithaaee iaaeii?iaiaith iecueei/anoioiith oaoai?/iith noeioeyoe??th. I?ney oaoai?/iiai iiae?aciaiiy eieaoa?aeae Oaooa?a i?ioyaii 10 - 15 oaeeei niinoa??aaeany cai?ioia aeai?an?y iCINI i??ai?aeieo iae?ii?a ae?eyiee NA1, eiee aiie?ooaea iCINI i??ai?aeieo iae?ii?a ae?eyiee NA1 ciaiooaaeany ia 20-30% uiaei aeo?aeii? aaee/eie. I?ney oeueiai, ii/eiath/e c 20-? oaeeeie, niinoa??aaeany a?aeno?i/aia OIOI neiaioe/ii? ia?aaea/?, ui aeinyaaea iaeneiaeueii? aaee/eie /a?ac 30-40 oaeeeie. Aieea ea?aaoeaoaio, iiiaeoo?eo oa ao?i?cieo ia OIOI neiaioe/ii? ia?aaea/? a nenoai? eieaoa?ae? Oaooa?a - i??ai?aei? iae?iie ae?eyiee NA1, ni?e/eiaio iecueei/anoioiith noeioeyoe??th, aecia/a?oueny o?ueiia iiiaioaie: ciaioaiiyi aeai?an?? iCINI, ca?eueoaiiyi ?o aiie?ooaee ? o?eaaeino? aeni?an?? OIOI. I??aoeaoai iineaaeth? aieea aeai?an?? iCINI i??ai?aeieo iae?ii?a ae?eyiee NA1, oiia?eueith? niaae OIOI neiaioe/ii? ia?aaea/? ? ia ni?aaey? ?noioiiai aieeao ia aiie?ooaeo iCINI. Iaea?eueo aeoeaieie uiaei aieeao ia OIOI neiaioe/ii? ia?aaea/?, iaoiiaeaii? iecueei/anoioiith oaoai?/iith noeioeyoe??th neiaioe/ieo aoiae?a, ? iiiaeooee ? ea?aaoeaoai, iaio aeoeaiei ao?i?cie. Oaeei /eiii, aieea iiio?iiieo ?a/iaei ia ??ciiiai?oi? oi?ie OIOI neiaioe/ii? ia?aaea/? aecia/a?oueny o?ueiia aoaeoaie: cieaeaiiy ii?iaa OIOI, ca?eueoaiiy aiie?ooaee iioaioe?eiaaieo CINI oa ?noioia ca?eueoaiiy o?eaaeino? OIOI neiaioe/ii? ia?aaea/?. Inoaii?i aoaiii o aea/aii? aieeao iiio?ii?a ia oeaio?aeueio aeooaiaoa?a?/io neiaioe/io ia?aaea/o aoei aeine?aeaeaiiy caeaaeiino? aoaeo?a iiio?iiieo ?a/iaei a?ae ?oiuei? eiioeaio?aoe??. Aeiaaaeaii, ui caeaaei?noue iioaioe?thth/iai aieeao iiio?iiieo ?a/iaei ia a?aeiia?ae? iae?ii?a coa/anoie caeaeie, iiina?aaeeiaai? aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a iaea aecaiiiiiae?aio oi?io (iaethiie 1, A). Caeaaei?noue IIAeA iioaioe?thth/iai aoaeoo a?ae eiioeaio?aoe?? iiio?iiii? ?a/iaeie oaeiae iaea aeno?aiaeueiee oa?aeoa? (iaethiie 1, A). Iaethiie.1 E?ea? caeaaeiino? iioaioe?thth/iai aieeao i??aoeaoaio (1), ao?i?cieo (2), ea?aaoeaoaio (3) e iiiaeooeeo (4) ia aiie?ooaeo iCINI iae?ii?a coa/anoie caeaeie a?ae eiaa??oia eiioeaio?aoe?? iiio?ii?a (A). E?ea? caeaaeiino? i?aeneeaiiy IIAeA- iioaioe?thth/i? ae?? i??aoeaoaio (1), ao?i?cieo (2), ea?aaoeaoaio (3) ? iiiaeooeeo (4) a?ae eiaa?eoia ?o eiioeaio?aoe?? (A) Ii aa?oeeaeuei?e in? – aoaeo a %, ii ai?eciioaeuei?e a?ae’?ii? eiaa?eoie eiioeaio?aoe?e iiio?iiieo ?a/iaei. Aeine?aeaeoaaee aieea ??cieo eiioeaio?aoe?e iiio?ii?a ia aeaeo?e/io caoaeeea?noue iae?ii?a a?iieaiio, eio?o iiina?aaeeiaaii ioe?ithaaee ca aie?ooaeith iiioeyoe?eieo niaee?a i??ai?aeieo iae?ii?a ae?eyiee NA1 a?iieaiio, ni?e/eithaaieo aeaeo?e/iei iiae?aciaiiyi aenii?a oeeo iae?ii?a, ui i?ioiaeyoue a aeueaaiey?iiio oa??. An? iiio?iie, ui a?a/aeenue, aeeeeeaee i?aeaaeuaiiy aiie?ooaee iiioeyoe?eieo niaee?a i??ai?aeieo iae?ii?a ae?eyiee NA1 (iaethiie 2). Oei na?ae/eoue i?i i?aeaeuaiiy aeaeo?e/ii? caoaeeeaino? iiio?iiaie ia?aiaeo ee?oei. E?eaa caeaaeiino? aeica - aoaeo oaeiae iaea aecaiiiiiae?aio oi?io(iaethiie 2). Ia i?aenoaa? aeyaeaieo caeaaeiioae ??cieo aoaeo?a, ni?e/eiaieo iiio?iiaie, a?ae ?o eiioeaio?aoe?? ?ic?aoiaai? aaee/eie AN50 aoaeo?a iiio?iiieo ?a/iaei, eio?? iaaaaeai? o oaaeeoe? 9. Ia i?aenoaa? aeaieo iaaaaeaieo a oaae.9, c?iaeaia iao?eoey ei?aeyoe?? ??cieo a?aeia aeoeaiino? aeine?aeaeoaaieo iiio?ii?a, eio?a aeicaiey? aeneiaeoe aeaye? aeoiee uiaei iiaeeeaeo ca’yce?a i?ae ee?oeiieie oa nenoaiieie aoaeoaie iiio?ii?a. Anoaiiaeaii noaoenoe/ii a??ia?aeiee ei?aeyoe?eiee ca’ycie (r=+0,9) i?ae caeaoi?noth ?a/iaei ca?eueooaaoe oaiinaineoeai?noue AI?A/ea?iaoieo ?aoeaioi??a oa iiaeeea?noth i?ieiiaiaoaaoe OIOI a neiaioe/i?e nenoai? ia?oi?aioiee oeyo-ca?ieno? ee?oeie coa/anoi? caeaeie. Iaethiie 2. Aieea iiio?iiieo ?a/iaei ia aiie?ooaeo aioeae?iiieo iiioeyoe?eieo niaee?a i??ai?aeieo iae?ii?a ae?eyiee NA1. A – e?ea? caeaaeiino? iioaioe?thth/iai aieeao i??aoeaoaio (1), ao?i?cieo (2), ea?aaoeaoaio (3) e iiiaeooeeo (4) ia aiie?ooaeo aioeae?iiieo iiioeyoe?eieo niaee?a a?ae eiaa??oia ?o eiioeaio?aoe??. Ii ai?eciioaeueii? in? –a?ae’?ii? eiaa?eoie eiioeaio?aoe?? iiio?iiieo ?a/iaei, ii aa?oeeaeuei?e – aoaeo a %. A – caa?oo aeiieco: aeo?aeiee aioeae?iiiee IN, eiai ci?ie ia oe? ae?? ea?aaoeaoaio a eiioeaio?aoe?yo 0,3 e 1 ieI. Aeine?aeaeoaaee aieea ??cieo eiioeaio?aoe?e iiio?iiieo ?a/iaei ia o?eaae?noue eeane/ii? IIAeAcaeaaeii? oi?ie OIOI neiaioe/ii? ia?aaea/? a nenoai? ia?oi?aioiee oeyo – ca?ieno? ee?oeie coa/anoie caeaeie. Anoaiiaeaii ui, iiio?iii? ?a/iaeie eiioeaio?aoe?eiicaeaaeiei caniaii ca?eueoothoue o?eaae?noue IIAeAcaeaaeii? oi?ie OIOI neiaioe/ii? ia?aaea/? a nenoai? ia?oi?aioiee oeyo – ca?ieno? ee?oeie coa/anoie caeaeie. Ni?e/eiaia iiio?iiaie ca?eueoaiiy aiie?ooae? CINI ca ?aooiie ciaioaiiy aeanaineoecaoe?? AI?A/ea?iaoieo ?aoeaioi??a ni?ey? aeoeaaoe?? a?eueoiai /enea IIAeA A? (oeyoii ciaioaiiy Ig aeieo ?o ?iiieo eaiae?a) i?ioyaii oaoai?/ii? noeioeyoe??. Oea caaacia/o? cieaeaiiy ii?iaa ?iaeoeoe?? oa ca?eueoaiiy o?eaaeino? aeni?an?? OIOI neiaioe/ii? ia?aaea/?. Oaeei /eiii, ni?e/eiai? iiio?iiaie ca?eueoaiiy oaiinaineoeaiino? AI?A/ea?iaoieo ?aoeaioi??a aiineoue cia/iee aeeaae a ?iaeoeoe?th oa aeni?an?? OIOI. A naith /a?ao i?aeaeuaiiy oaiinaineoeaiino? ?iiioi?ieo aeooaiaoieo ?aoeaioi??a ia ei?aeth? c aioeaiianoe/iith ae??th iiio?ii?a. C inoaii?i aeaeii aeoeaiino? iiio?ii?a cia/eii ei?aeththoue (r=+0,7) iaoiiaeai? ae??th iiio?ii?a i?aeaeuaiiy aeaeo?e/ii? caoaeeeaino? iae?ii?a ? i?ieiiaoaaiiy OIOI neiaioe/ii? ia?aaea/?. Oaaeeoey 8. Aaee/eia AN50 (ieI) ??cieo yooaeo?a aeine?aeaeo?ieo iiio?iiieo ?a/iaei. ?a/iaeiaI?aeaeuaiiy oaiinaineoeaiino? IIAeA A?I?aeaeuaiiy oaiinaineoeaiino? AI?A /ea?iaoieo ?aoeaioi??aI?aeaeuaiiy yeaeo?e/ii? caoaeeeaino? iae?ii?aI?ieiiaaoe?y AeIOI neiaioe/ii? ia?aaea/?Aioeaiianoe/ia ae?y ieI/eaI??aoeaoai213,2831450,4870771600450Yoeiecie112,4273,80,70,1111,962 Ea?aaoeaoai10,130,20,50,0320,2193Iiiaeooee0,80,11,30,10,40,021,50,1163Ae eoeei **0,50,3--222,41800450*- aeai? caiice/ai? c ?iaioe (Eiienna?ia E.A., Eaueineay A.ss., 1995) ** - aeai? caiice/ai? c ?iaioe (Aa?eaiaa A.E. e niaao.,1990) Aeyaeai? ia i?aenoaa? ei?aeyoe?eiiai aiae?co iae?iii? oa neiaioe/i? aoaeoe, ni?e/eiai? iiio?iiieie ?a/iaeiaie, eio?? cia/ii ei?aeththoue c ?o aioeaiianoe/iith ae??th o aeine?aeao, iia’ycaieo c aea/aiiyi iiaaae?iee aeicaiey? ?aeiiaiaeoaaoe ni?iiiaei?noue aeine?aeaeoaai?o ?a/iaei iineethaaoe a?aeiia?ae? ia?aiaeo ee?oei, iiina?aaeeiaai? aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, ? ca?eueooaaoe o?eaae?noue o?eaaei? iinooaoai?/ii? iioaioe?aoe?? neiaioe/ii? ia?aaea/? a c??cao a?iieaiio a?ecoiia ye i?iaiinoe/i? e?eoa??? aeey ne?ei?iaa oa?iaeieia?/ieo ?a/iaei c iioaioe?eiith iiio?iiiith aeoeai?noth. AENIIAEE 1. Anoaiiaeaii, ui i??aoeaoai, ea?aaoeaoai, ao?i?cie, iiiaeooee ca?eueoothoue aiie?ooaeo a?aeiia?aeae nieiaeueieo iioiiae?ii?a, iiina?aaeeiaaieo aeoeaaoe??th IIAeA aeooaiaoieo ?aoeaioi??a. Ea?aaoeaoai, ao?i?cie, iiiaeooee, aea ia i??aoeaoai, aeyaeythoue IIAeA-nainea?e?coth/o ae?th o aeine?aeao ia iae?iiao c??c?a a?iieaiio uo??a. 2. Aeiaaaeaii,ui ni?e/eiaia iiio?iiaie i?aeaeuaiiy oaiinaineoeaiino? IIAeA aeooaiaoieo ?aoeaioi??a ia? o nai?e i?e?iae? iaoaaie?/io iiaeoeyoe?th IIAeA ?aoeaioi?ii-eaiaeueieo eiiieaen?a, ui coiiaeaia i?aeaeuaiiyi aeoeaiino? i?ioa?ie?iac ? oinoi?eethaaiiyi aioo??oiueiee?oeiieo aeiiai?a ?aoeaioi??a. 3. Anoaiiaeaii, ui i??aoeaoai, ea?aaoeaoai, ao?i?cie, iiiaeooee o i?e?iiiey?ieo eiioeaio?aoe?yo ca?eueooaaee aiie?ooaeo a?aeiia?aeae ia?aiaeo ee?oei a?iieaiio uo??a, iiina?aaeeiaaieo aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a. 4. Nainea?e?coth/ee aieea i??aoeaoaio, ea?aaoeaoaio, ao?i?cieo ? iiiaeooeeo ia iaIIAeA aeooaiaoi? ?aoeaioi?e coiiaeaii i?aeaeuaiiyi aeoeaiino? eaeueiiaeoe?io, eaeueiiaeoe?icaeaaeii? i?ioa?ie?iace ?? e Na2+-ae?aoeeeae?oea?eicaeaaeii? i?ioa?ie?iace N, aeoeai?noue yeeo iiio?iii? ?a/iaeie noeioeththoue ca o/anoth oinoi?iiceoeaeace N ? ?aaoeyoi?ieo Gp-a?ee?a. 5. Aeyaeaii, ui aeine?aeaeai? iiio?iii? ?a/iaeie iieaaoothoue ?iaeoeoe?th oa ca?eueoothoue o?eaae?noue IIAeAcaeaaeii? oa IIAeAiacaeaaeii? oi?i o?eaaei? iinooaoai?/i? iioaioe?aoe?? neiaioe/ii? ia?aaea/? o ??cieo neiaioe/ieo nenoaiao a?iieaiio uo??a. 6. Anoaiiaeaii,ui caeaaei?noue aieeao aeine?aeaeaieo iiio?iiieo ?a/iaei ia oaiinaineoeai?noue ?iiioi?ieo aeooaiaoieo ?aoeaioi??a ? ia o?eaae?noue ieanoe/ieo neiaioe/ieo oaiiiai?a a?ae ?o eiioeaio?aoe?? iieno?oueny e?eaith, ui ia? aecaiiiiiae?aio oi?io. Ciaioaiiy aooaeo?a iiio?iiieo ?a/iaei a caeaaeiino? a?ae ca?eueoaiiy ?o eiioeaio?aoe?? coiiaeaii aiii- oa aaoa?ieia?/iith aeanaineoecaoe??th ae?eyiie niaoeeo?/iiai cacycoaaiiy iiio?ii?a o iaia?aiao ia?aiaeo ee?oei. 7. Aeyaeaii cia/ei? ei?aeyoe?? i?ae ni?e/eiaiei iiio?iiieie ?a/iaeiaie i?aeaeuaiiyi oaiinaineoeaiino? AI?A/ea?iaoieo ?aoeaioi??a ? i?ieiiaoaaiiyi o?eaaei? iinooaoai?/ii? iioaioe?aoe?? oa aioeaiianoe/iith ae??th iiio?ii?a. 8. sse iae?iii? aoaeoe, ui iiaeooue aooe aeei?enoai? aeey ne?ei?iaa oa?iaeieia?/ieo ?a/iaei c iioaioe?eiith iiio?iiiith aeoeai?noth, ?aeiiaiaeo?oueny nainea?e?coth/ee aieea aeine?aeaeaieo iiio?iiieo ?a/iaei ia a?aeiia?ae? iae?ii?a, iiina?aaeeiaai? aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, ? caeaoi?noue i?ieiiaoaaoe o?eaaeo iinooaoai?/io iioaioe?aoe?th neiaioe/ii? ia?aaea/? o c??cao a?iieaiio nnaaoe?a. Oeaio?aeuei? iae?iie aeaa aeey a?aeai?o iiio?ii?a iai?eaeaoi?. Cienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe?? 1. Aa?aiaoe E.E., Aiae?aaa I.A., Eiienna?ia E.A., Naiieeiae/ E.I., Oeoeaaneee A.A. Iiio?iiu iioaioee?otho ioaaou ia?aiuo eeaoie, aucuaaaiua aeoeaaoeeae IIAeA-aeooaiaoiuo ?aoeaioi?ia // Atheeaoaiue yenia?eiaioaeueiie aeieiaee e iaaeeoeeiu.-1993.-?1.-N.51-53. 2. Aa?aiaoe E.E., Aiae?aaa I.A., Eiienna?ia E.A., Naiieeiae/ E.I. Iioaioeeaoeey iiio?iiaie iae?iiiuo ioaaoia, iiin?aaeoaiuo aeoeaaoeeae ia IIAeA aeooaiaoiuo ?aoeaioi?ia // Iae?ioeceieiaey.-1994.-O.26, ?5.-N.365-372. 3. Aa?aiaoe E.E., Aiae?aaa I.A., Naiieeiae/ E.I. 2,4-aeeieo?ioaieeaeeoeei eae aaiieno iaoaaio?iiiuo aeooaiaoiuo ?aoeaioi?ia // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.-oii.7, ?2.-N.156-160. 4. Aiae?aaa I.A. Aeeyiea iiio?iiia ia ioaaou iae?iiia, iiin?aaeiaaiiua IIAeA aeooaiaoiuie ?aoeaioi?aie // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu (nai?iee noaoae).- Aeiiaoee.:“Eaaaaeue”.-auione 2, oii 1.-1998.-N.8-10. 5. Aiae?aaa I.A. Aeeyiea iiio?iiiuo aauanoa ia aeeeoaeueioth iinooaoaie/aneoth iioaioeeaoeeth a ?acee/iuo neiaioe/aneeo nenoaiao aeiiieaiia e?un // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu (nai?iee noaoae).- Aeiiaoee.:“Eaaaaeue”.-auione 3, oii 1.-1999.-N. 5-8. 6. Aiae?aaa I.A. Eiee/anoaaiiua caeiiiia?iinoe aeaenoaey iiio?iiiuo aauanoa // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu (nai?iee noaoae).- Aeiiaoee.:“Eaaaaeue”.-auione 3, oii 2.-1999.-N.-9-11. 7. Aa?aiaoe E.E., Naiieeiae/ E.I., Aiae?aaa I.A. Iae?iiiay iiaeaeue aeey ioai?a oa?iaeieiae/aneeo aauanoa n iioaioeeaeueiie aioeaiianoe/aneie aeoeaiinoueth // Aenia?eiaioaeueia oa?iaeieia?y – ee?i?oe? (oace aeiiia?aeae).-A?iieoey-Ee?a,1992.-N.3-4. 8. Aa?aiaoe E.E., Aiae?aaa I.A. Iiio?iiu eae iiaeoeyoi?u oaiinaineoeaiinoe iinoneiaioe/aneeo aeooaiaoiuo ?aoeaioi?ia // Iaoa?eaeu iaaeiaeanoiie iao/ii-i?aeoe/aneie eiioa?aioeee iinayuaiiie 25-eaoiaio thaeeath eaoaae?u aieaciae ooa ai?ea e iina oaeoeueoaoa oniaa?oainoaiaaiey a?a/ae.-Aeiiaoee, 1994.-N.70. 9. Aiae?aaa I.A. O/anoea i?ioaeieeiac e ae?oaeo aioo?eeeaoi/iuo oa?iaioia a iioaioeee?othuai aeeyiee iiio?iiia ia ioaaou iae?iiia, iiin?aaeoaiua aeoeaaoeeae ia IIAeA aeooaiaoiuo ?aoeaioi?ia // Aeooaeueiua i?iaeaiu iaaeeoeeiu Aeiiaanna (oacenu aeieeaaeia iao/iie eiioa?aioeee).-Aeiiaoee, 1996.-N.11. 10. Aiae?a?a I.A. Aaeaeaaoi?noue aeei?enoaiiy iioiiae?ii?a nieiiiai iiceo aeaae ye iiaeae? aeey aeine?aeaeaiiy aca?iiae?? iiio?ii?a ? aeooaiaoieo ?aoeaioi??a // O?c?ieia?/iee aeo?iae.-1998.-oii 44, ?3.-N.14. Aiiioaoe?? Aiae???a I.A. Iiio?iii? ?a/iaeie ye iiaeoeyoi?e oeaio?aeueii? aeooaiaoa?ae/ii? neiaioe/ii? ia?aaea/?.-?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca oaoii 14.03.05 – Oa?iaeieia?y. ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie, Ee?a, 1999 . Caoeua?oueny iaoeiaa i?aoey, eio?a i?noeoue aenia?eiaioaeuei? aeai? uiaei iiio?iiieo ?a/iaei ye iaoaaie?/ieo iiaeoeyoi??a oaiinaineoeaiino? oeaio?aeueieo iinoneiaioe/ieo aeooaiaoieo ?aoeaioi??a. Aeiaaaeai? ?acoeueoaoe aeine?aeaeaiiy aieeao iiio?iiieo ?a/iaei ia ooieoe?? iinoneiaioe/ieo AI?A/ea?iaoieo, IIAeA aeooaiaoieo ?aoeaioi??a a oeaio?aeueieo iae?iiao aeaa ? uo??a, ia oaiiiai o?eaaei? iinooaoai?/ii? iioaioe?aoe?? a iae?iiao a?iieaiio uo??a. Aeiaaaeaii, ui a iniia? i?aeaeuaiiy oaiinaneoeaiino? iinoneiaioe/ieo aeooaiaoieo ?aoeaioi??a ?iiina?aaeeiaai? AOOcaeaaeieie a?eeaie i?aeaeuaiiy aioo?eoiueiiae?iiaeueii? eiioeaio?aoe?? Na2+ c iine?aeiaiith aeoeaaoe??th eaeueiiaeoe?io, Na/eaeueiiaeoe?icaeaaeii? i?ioa?ie?iace ?? ? i?ioa?ie?iace N. Aeoeaaoe?y i?ioa?ie?iac ni?ey? oinoi?eethaaiith aioo?eoiueiee?oeiieo aeiiai?a aeooaiaoieo ?aoeaioi??a ? i?aeaeuaiith ?o oaiinaineoeaiino?. Caeaoi?noue aeine?aeaeoaaieo ?a/iaei i?aeneethaaoe aoaeoe ia?aiaeo ee?oei, iiina?aaeeiaai? aeoeaaoe??th AI?A/ea?iaoieo ?aoeaioi??a, oa ca?eueooaaoe o?eaaeenoue o?eaaei? iinooaoai?/ii? iioaioe?aoe?? o c??cao a?iieaiio a?ecoi?a iiaeooue aooe aeei?enoiaai? ye e?eoa??? aeey ne?ei?iao ?a/iaei n iioaioe?eiith iiio?iiiith aeoeai?noth. Eeth/ia? neiaa: iiio?iie, iiaeoeyoe?y, aeooaiaoi? ?aoeaioi?e, a?iieaii, aeooaiaoa?a?/i? neiaine. Aiae?aaa I.A. Iiio?iiiua aauanoaa eae iiaeoeyoi?u oeaio?aeueiie aeooaiaoa?ae/aneie neiaioe/aneie ia?aaea/e.-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.05. – Oa?iaeieiaey. Einoeooo oa?iaeieiaee e oieneeieiaee AII Oe?aeiu, Eeaa, 1999 . Aeenna?oaoeey iinayuaia eco/aieth iaoaieciia aeaenoaey iiio?iiiuo n?aaenoa, iieneo iiauo iaoiaeia aeey ioai?a n?aaenoa n iioaioeeaeueiie iiio?iiiie aeoeaiinoueth. Oeaeue ?aaiou caeeth/aeanue a oi?ie?iaaiee ia iniiaa yenia?eiaioaeueii iieo/aiiuo aeaiiuo aeiioacu i iiio?iiiuo aauanoaao eae iaoaaiee/aneeo iiaeoeyoi?ao oaiinaineoeaiinoe oeaio?aeueiuo iinoneiaioe/aneeo aeooaiaoiuo ?aoeaioi?ia. A ia?aie /anoe ?aaiou eco/aii aeeyiea iiio?iiiuo aauanoa (ie?aoeaoaia, aeeiaoeeaieiiyoaiiea, yoeieciea, iiiaeooeea e ea?aaoeaoaia) ia iinoneiaioe/aneea AI?A/eaeiaoiua e IIAeA aeooaiaoiua ?aoeaioi?u a oeaio?aeueiuo iae?iiao eyaooee e e?unu. Onoaiiaeaii, /oi a iniiaa iiauoaiey oaiinaineoeaiinoe iinoneiaioe/aneeo aeooaiaoiuo ?aoeaioi?ia eaaeeo iiin?aaeiaaiiia AOO-caaeneiuie aaeeaie iiauoaiea aioo?eiae?iiaeueiie eiioeaio?aoeee Na2+ n iineaaeothuae aeoeaaoeeae eaeueiiaeoeeia, Na/eaeueiiaeoeeicaaeneiie i?ioaeieeiacu II e i?ioaeieeiacu N. Aeoeaaoeey i?ioaeieeiac i?eaiaeeo e oinoi?eee?iaaieth aioo?eeeaoi/iuo aeiiaiia aeooaiaoiuo ?aoeaioi?ia e iiauoaieth eo oaiinaineoeaiinoe. Ai aoi?ie /anoe ?aaiou i?eaaaeaiu ?acoeueoaou enneaaeiaaiey aeeyiey iiio?iiiuo aauanoa ia oaiiiai aeeeoaeueiie iinooaoaie/aneie iioaioeeaoeee neiaioe/aneie ia?aaea/e a iae?iiao aeiiieaiia e?unu. Iiio?iiiua aauanoaa iaeaa/aee eiaeoeoeeth, a oaeaea oaaee/eaaee i?iaeieaeeoaeueiinoue aeeeoaeueiie iinooaoaie/aneie iioaioeeaoeee neiaioe/aneie i?aaea/e, /oi oaaaeeoaeueii aeieacuaaao iioaioee?othuaa aeaenoaea iiio?iiia ia oeaio?aeueioth aeooaiaoa?ae/aneoth neiaioe/aneoth ia?aaea/o. Iieacaii /oi a iniiaa iioaioee?othuaai aeeyiey iiio?iiia ia neiaioe/aneoth ia?aaea/o eaaeeo iiaeoee?othuaa aeeyiea iiio?iiiuo aauanoa ia iinoneiaioe/aneea aeooaiaoiua ?aoeaioi?u. Oaeaea enneaaeiaaiu eiee/anoaaiiua caeiiiia?iinoe aeaenoaey iiio?iiiuo aauanoa ia ?aoeaioi?iii e neiaioe/aneii o?iaiyo. Iieacaia yeno?aiaeueiay oi?ia caaeneiinoe yooaeoia iiio?iiiuo aauanoa io eo eiioeaio?aoeee. Nieaeaiea yooaeoia iiio?iiiuo aauanoa ii iia?a oaaee/aiey eo eiioeaio?aoeee iauyniyaony aiii- e aaoa?ieiae/aneie aeanaineoecaoeeae o/anoeia niaoeaoe/aneiai naycuaaiey iiio?iiia. Onoaiiaeaia aeinoaoi/ii oaniay ei??aeyoeeiiiay naycue iaaeaeo niiniaiinoueth iiio?iiiuo aauanoa e iiauoaieth oaiinaineoeaiinoe AI?A/eaeiaoiuo ?aoeaioi?ia e i?ieiiaaoeeae aeeeoaeueiie iinooaoaie/aneie iioaioeeaoeee neiaioe/aneie ia?aaea/e. Iaeiaei iiauoaiea oaiinaineoeaiinoe eiiioi?iuo aeooaiaoiuo ?aoeaioi?ia ia ei?aee?oao n aioeaiianoe/aneei aeaenoaeai iiio?iiia. N aioeaiianoe/aneei aeaenoaeai cia/eoaeueii ei?aee?otho aucuaaaiia iiio?iiaie iiauoaiea yeaeo?e/aneie aicaoaeeiinoe iae?iiia e i?ieiiae?iaaiea aeeeoaeueiie iinooaoaie/aneie iioaioeeaoeee neiaioe/aneie i?aaea/e. Niiniaiinoue enneaaeoaiuo aauanoa oneeeaaoue ioaaou ia?aiuo eeaoie, iiin?aaeiaaiiua aeoeaaoeeae AI?A/eaeiaoiuo ?aoeaioi?ia, e oaaee/eaaoue i?iaeieaeeoaeueiinoue aeeeoaeueiie iinooaoaie/aneie iioaioeeaoeee a n?acao aeiiieaiia a?ucoiia i?aaeeiaeaia a ea/anoaa e?eoa?eaa aeey ne?eieiaa aauanoa n iioaioeeaeueiie iiio?iiiie aeoeaiinoueth. Caeaeai auaiae i iaoeaeaniia?aciinoe eniieueciaaiey iioiiae?iiia nieiiiai iicaa eyaooee a ea/anoaa iiaeaee aeey ioai?a oa?iaeieiae/aneeo aauanoa n iioaioeeaeueiie iiio?iiiie aeoeaiinoueth. Eeth/aaua neiaa: iiio?iiu, iiaeoeyoeey, aeooaiaoiua ?aoeaioi?u, aeiiieaii, aeooaiaoa?ae/aneea neiainu. Annotation Andreev P.V. Nootropic drugs as modulators of central glutamatergic synaptic transmission.-Manuscript. Dissertation for seeking a degree of kandidate of medical sciences in speciality 14.03.05 – Pharmacology. Institute of Pharmacology and Toxicology of AMS of Ukraine, Kiev, 1999. It is defending a scientific work which contains experimental data about nootropic drugs as metabolic modulators of chemosensitivity of central postsynaptic glutamate receptors. There were adduced results of iinvestigation of the nootropic drugs’ influence on the functions of postsynaptic kainate receptors in central neurons of the frog and the rat, on the phenomenon of long-term potentiation in the hippocamp’s neurons of the rat. It is established that modulated by GTP-depending proteins increase of intraneuronal concentration Ca2+ with subsequent activation ofcalmodulin, Ca/calmodulin-depending protein kinase II and protein kinase C. Activation of protein kinases leads to phosporylation of intracellular domains of glutamate receptors and their chemosensitivity increase. The ability of examined substances to intensify responses of nerve cells, mediated by activation of kainate receptors and to increase duration of long-term potentiation in the hippocamps sections of the rodents were offered as criteria for screening of substances with potential nootropic activity. Key words: nootropic drugs, modulation, glutamate receptors, hippocamp, glutamatergic synapses.

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