3

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

AIAOI Ea?ena Ay/aneaa?aia

OAeE 616.127 — 005.4 — 039.56: 616.12 — 009.72

«I?ia» ?oai?y i?iea?aea o oai?eo ia ianoaa?eueio noaiiea?ae?th

14.01. 11 — Ea?ae?ieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? oa?ai?? AII Oe?a?ie, i. Oa?e?a

Iaoeiaee ea??aiee — aeieoi? iaaee/ieo iaoe Oeaeoeei A??a Einei?aia,

caa?aeoth/a a?aeae?eii aaiaoeee aoa?ineea?ico ?inoeoooo oa?ai?? AII
Oe?a?ie, i. Oa?e?a

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe Eiaaeue Ieaia Ae?iaeei?aia, aeioeaio eaoaae?e
aini?oaeueii? oa?ai?? ? 2 Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii?
aeaaeai??

aeieoi? iaaee/ieo iaoe Aa?aciyeia ?ai? Aaiiaae?eiae/, caa?aeoaa/
eaoaae?e oa?ai?? Oa?e?anueeiai ?inoeoooo oaeineiiaeaiiy e?ea??a.

I?ia?aeia onoaiiaa — Oe?a?inueeee IAe? ea?ae?ieia?? ?i. aeaae. I. Ae.
No?aaeanea, IIC Oe?a?ie, i. Ee?a, a?aeae?e ?aai?iaoe?? oa ?ioaineaii?
oa?ai?? c eaai?aoi???th ee?i?/ii? aeaeo?io?c?ieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny «__8___» ____ea?oiy___ 1999 ?. i
_14.30__aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04
i?e Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i.
Oa?e?a, i?. Eai?ia,4).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia,4).

Aaoi?aoa?ao ?ic?neaiee «__6__» ____aa?aciy__ 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i, aeioeaio
Ia/a?aiei E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia «i?ii?» ?oai?? i?iea?aea (I?I) ? iaei??th
c iaea?eueo aeooaeueieo i?iaeai no/anii? ea?ae?ieia??, ui coiiaeaii ??
oe?ieei ?iciianthaeaeaiiyi i?e on?o ee?i?/ieo oi?iao ?oai?/ii? oai?iae
na?oey (?ON) ? ae?ae iani?eyoeeaei i?iaiinoe/iei cia/aiiyi (Aia?ia
A.A., Aacthe I.E., Aeaauaeiaa E.A.,1991).

O oai?eo ia ianoaa?eueio noaiiea?ae?th (IN) aea/aiiy I?I aeeeeea?
iniaeeaee ?ioa?an aiane?aeie a?eueoi? /anoioe ai?ciae?a I?I. E??i oiai,
I?I iiaea aaaaeaoeny iciaeith ee?i?/ii? iai?oanoaoe?? ?
aeanoaa?e?caoe?? ia?aa?ao ?ON (Einaeeaie Ae.A., Noaiia A.I., 1993).

Aeeneooaaaeueieie caeeoathoueny ieoaiiy i?i iaoiaaiaoe/i? iaoai?cie,
ui coiiaeththoue I?I. Aeieeiaiiy I?I iiyniththoue i?aeaeuaiiyi oiiono
ei?iia?ieo a?oa??e, aiane?aeie /iai a?aeaoaa?oueny ciaioaiiy iinoa/aiiy
eenith aei na?oeaaiai i’yca, i?aeaeuaiiyi iio?aae i?iea?aea a eeni? ?
ii?ooaiiyie a nenoai? aaiinoaco, i?ioa aeeaae oiai aai ?ioiai iaoai?cio
a ?icaeoie ai?ciae?a I?I aea/aiee iaaeinoaoiuei (Aieeia A.N., 1990;
Oauoe A.E., Iaeeiianeay E.Y.,1992).

A iaoiaaiac? IN ye aino?iai ei?iia?iiai neiae?iio aaeeea cia/aiiy
iaaea?oueny aeaoaeoo iiaa?oi? aoa?ineea?ioe/ii? aeyoee a ii?aeiaii? c?
noaiii a?ia?eiaaoeyoe?? e?ia?, aei iia?/ieo iciae yeiai a?aeiinyoue
i?aeaeuaiiy ai?noo a e?ia? o?a?eiiiaioeaea A, eiiieaen?a
o?iia?i-aioeo?iia?i ? i?iaeoeo?a aeaa?aaeaoe?? o?a?ei/o?a?eiiaaia
(IAeO). A oie aea /an iaaeinoaoiuei aea/aiee aca?iica’ycie oeeo
iieaciee?a ieaciiai? eaiee aaiinoaco c ia?aiao?aie I?I o oai?eo ia IN
(A?aoeeaineee I.A., 1996; Merlini P.A., Bauer K., Oltrona L. et
al.,1994;Reggiani S., Mattioli G.,1993).

Aeeeeea? ?ioa?an aea/aiiy ? iiaeeeai? ?ie? o?a?iiaeoeia (OI) a ?icaeoeo
?oai?? i?iea?aea, a oiio /ene? ? «i?ii?», a?aoiaoth/e eiai ?ieue a
aeoeaaoe?? i?ioean?a eiaaoeyoe?? e?ia?, a ?aci?aoe?? iae?ioeciaaii?
oeaieie, a oiio /ene? ? i?e IN, eiee a i?iea?ae? iaeaea caaaeaee ia?
i?noea iae?ic aiane?aeie aiaie?caoe?? ae??aieo noaeei na?oeaaiai i’yca
o?iiaioeeoa?ieie aa?aaaoaie (Aaneeueaa N.A., Ao?aiia A.A., Naaaiei O.A.
e ae?., 1994.; Iaeay E.O., Aieeia A.E., Oii/ee E.E. e ae?., 1990).

Oaeoi?aie, ui ni?eythoue ?icaeoeo ? i?ia?anoaaiith aoa?ineea?ico, ?
a?ia?oieanoa?eiai?y c ia?aaaaeiei ca?eueoaiiyi a ieaci? e?ia?
oieanoa?eio e?iii?ioa?ae?a iecueei? u?eueiino? (EIIU) ? cieaeaiiyi
eiioeaio?aoe?? e?iii?ioa?ae?a aeniei? u?eueiino? (EIAU) ( Oeaeoeei
A.E.,1993). Ine?eueee ?nio? ca’ycie i?ae eiioeaio?aoe??th EIIU a ieaci?
e?ia? ? a aoa?ineea?ioe/i?e aeyooe?, a oaeiae i?ae eiioeaio?aoe??th
aeoeaiaaiiai oaeoi?a VII ? eiioeaio?aoe??th a e?ia? o?eae?oea?eae?a
(OA), oi noa? c?icoi?eith aeooaeuei?noue aea/aiiy iniaeeainoae ii?ooaiue
e?i?aeiiai niaeo?a e?ia? i?e ??ciiio nooiai? oyaeeino? I?I, yea, ye
aeacoaaeiny aeua, iiaea aooe ia?ea?ii aeanoaa?e?caoe?? ?ON (Smith
E.B.,1995; Miller G.J.,1995).

Ia iaioee ?ioa?an aeeeeea? ? i?iaeaia iaaeeeaiaioicii? ei?aeoe?? «i?ii?»
?oai?? i?iea?aea. Ca?ac iniiaia cia/aiiy a e?eoaaii? I?I iaaeathoue
aeieaoi?ai aaoa-aae?aia?ae/ieo ?aoeaioi??a ? aioaaii?noai eaeueoe?th.
I?ioa aeai? i?i aioe?oai?/io aeoeai?noue oeeo i?aia?ao?a noia?a/eea?
(Fox K.M., Mulcahy D.,1990). Ia iaeiicia/ia ? ?ieue i?o?ao?a a e?eoaaii?
I?I: aeaye? aeine?aeieee ciaoiaeyoue ?o aioe?oai?/iee aoaeo iacia/iei
(Purcell H., Mulcahy D., Fox K.,1994).

Ia?aia iai?aaeaiiy aeine?aeaeaiue ca’ycaia c iaoeiaith ae?yeuei?noth ?
aoiaeeoue a oaiaoe/iee ieai ?inoeoooo oa?ai?? AII Oe?a?ie a yeino?
o?aaiaioa iaoeiai-aeine?aeii? ?iaioe ii oai? «Oa?aiaaoe/ia cia/aiiy
ei?aeoe?? aoii?aeueieo ? ee?oeiieo iaoai?ci?a «i?ii?» ?oai?? i?iea?aea
i?e ?oai?/i?e oai?ia? na?oey» N 0196U001365.

Iaoa ?iaioe: i?aeaeuaiiy aoaeoeaiino? oa?ai?? oai?eo ia ianoaa?eueio
noaiiea?ae?th ia i?aenoaa? aea/aiiy iaoiaaiaoe/ieo iaoai?ci?a ?
i?iaiinoe/iiai cia/aiiy «i?ii?» ?oai?? i?iea?aea oa ii??aiyeueii?
ioe?iee ??cieo noai e?eoaaiiy.

Caaaeaiiy aeine?aeaeaiiy. I?e aeeiiaii? ?iaioe aoee iinoaaeai? oae?
caaaeaiiy:

1. Aea/eoe iniaeeaino? «i?ii?» ?oai?? i?iea?aea ? iiaeeea? iaoiaaiaoe/i?
iaoai?cie ?? aeieeiaiiy i?e aeanoaa?e?caoe?? ?oai?/ii? oai?iae na?oey.

2. Aea/eoe ca’ycie i?ae iieacieeaie e?i?aeiiai iai?io oa ia?aiao?aie
«i?ii?» ?oai?? i?iea?aea o oai?eo ia ianoaa?eueio noaiiea?ae?th.

3. Aea/eoe ca’ycie i?ae ia?aiao?aie «i?ii?» ?oai?? i?iea?aea ? aeayeeie
iieacieeaie nenoaie cai?oaiiy e?ia? o oai?eo ia ianoaa?eueio
noaiiea?ae?th.

4. Aecia/eoe oaeoi?e, ye? aieeaathoue ia iaeaeeae/ee oa a?aeaeaeaiee
i?iaiic i?e ianoaa?euei?e noaiiea?ae??.

5. Ioe?ieoe aoaeoeai?noue oa?ai?? i?o?aoaie, aaoa-aeieaoi?aie ?
aioaaii?noaie eaeueoe?th o oai?eo ia ianoaa?eueio noaiiea?ae?th c
ai?ciaeaie «i?ii?» ?oai?? i?iea?aea.

Iaoeiaa iiaecia.

1. Anoaiiaeaii, ui aeanoaa?e?caoe?y ia?aa?ao noaiiea?ae??
oa?aeoa?eco?oueny ia o?eueee ca?eueoaiiyi ee?i?/ieo i?iya caoai?thaaiiy,
aea e ca?eueoaiiyi /anoioe, na?aaeiuei? oa noia?ii? o?eaaeino?
ai?ciae?a I?I.

2. Aeyaeai? aeaye? iniaeeaino? iaoiaaiaoe/ieo iaoai?ci?a, ui
coiiaeththoue iiyao I?I i?e IN. Oae noai ieaciiai? eaiee aaiinoaco ia
caeaaeaa a?ae oa?aeoa?o ?oai?? i?iea?aea (aieueiaa /e «i?ia»), a oie /an
ye anoaiiaeaii, ui a?eueo cia/i? ci?ie ??aiy OI ? o?a?eiiaaio (OA)
noi?iaiaeaeothoueny ca?eueoaiiyi noia?ii? o?eaaeino? I?I (NO I?I) ?
/ano?oa cono??/athoueny o oai?eo c ai?ciaeaie ?oai??, yea ?icaeaa?oueny
aac nooo?aiai i?e?inoo /anoioe na?oeaaeo nei?i/aiue (*NN).

3. Aecia/ai? e?eoa??? iani?eyoeeaiai iaeaeeae/iai oa a?aeaeaeaiiai
i?iaiico o oai?eo ia IN, a naia iayai?noue /anoeo ? o?eaaeeo i?enooi?a
noaiiea?ae?? oa I?I noia?iith o?eaae?noth a?eueo 60 oaeeei ca 24 aiaeeie
nooo?aei /eiii aieeaa? ia oneeaaeiaiiy ia?aa?ao IN, a oie /an ye
a?aeaeaeaiee i?iaiic caeaaeeoue a?ae iayaiino? ai?ciae?a I?I ia oe?
aioeaia?iaeueii? oa?ai?? oa nooiaiy ii?ooaiiy e?i?aeiiai iai?io.

4. ?ic?iaeai? iioeiaeuei? aeeoa?aioe?eiaai? noaie aioeaia?iaeueii?
oa?ai?? oai?eo ia IN c ai?ciaeaie I?I, iieacaia iaiao?aei?noue
aeeth/aiiy aei noaie e?eoaaiiy oaeeo oai?eo aaoa-aeieaoi?a aoaiieiea aai
aioaaii?noa eaeueoe?th ae?eo?acaia ia i?aenoaa? iniaeeainoae
iaoio?c?ieia?/ieo iaoai?ci?a I?I o eiie?aoiiai oai?iai.

I?aeoe/ia cia/ei?noue ?iaioe.

1. Iieacaia iaiao?aei?noue i?iaaaeaiiy aeiaiaiai iii?oi?oaaiiy AEA (AeI
AEA) o oai?eo ia IN aeey aeyaeaiiy ?noeiii? /anoioe ?oai?/ieo ii?ooaiue,
i?iaiicoaaiiy ia?aa?ao caoai?thaaiiy, aeai?o aoaeoeaii? aioeaia?iaeueii?
oa aioe?oai?/ii? oa?ai??.

2. Aeyaeai? a?oie oai?eo ia IN, o yeeo ?iia??i?noue ?icaeoeo I?I
iaea?eueo aeniea — oea oai?? c oeoe?iaei ae?aaaoii, a?oa??aeueiith
a?ia?oaic??th, iino?ioa?eoiei ea?ae?ineea?icii.

3. Iaa?oioiaaia iaiao?aei?noue aeeth/aiiy aei noaie iaaeeeaiaioiciiai
e?eoaaiiy oai?eo ia IN aoaiieiea aai ae?eo?acaia a caeaaeiino? a?ae
ia?aaaae oiai /e ?ioiai iaoiaaiaoe/iiai iaoai?cio I?I: aoaiieie a?eueo
aoaeoeaii aieeaa? ia ai?ciaee I?I, ui ia?aa?aathoue c aeai?an??th
naaiaioa ST ca aeaieie AeI AEA, a oie /an ye ae?eo?acai a?eueo oni?oii
eoi??o? ai?ciaee I?I, ui noi?iaiaeaeothoueny aeaaaoe??th naaiaioa ST.

4. Anoaiiaeai? e?eoa??? ?aiiueiai iani?eyoeeaiai i?iaiico o oai?eo ia
IN, aei yeeo a?aeiinyoueny iayai?noue /anoeo (c i?i?iaeueiei
aacaia?iiciei ?ioa?aaeii iaioa 1 aiaeeie) oa o?eaaeeo (a?eueo 15 oaeeei)
i?enooi?a noaiiea?ae??, a oaeiae iayai?noue I?I noia?iith o?eaae?noth 60
oaeeei ? a?eueoa ca 24 aiaeeie.

5. Aecia/ai? e?eoa??? a?aeaeaeaiiai iani?eyoeeaiai i?iaiico o oai?eo ia
IN: iayai?noue ai?ciae?a I?I ia oe? aioeaia?iaeueii? oa?ai?? c?
caa?aaeaiiyi ?aieiaiai i?eo a oee?eaaei?e ia??iaee/iino? oa
a?aenooi?noth a??ia?aeiiai i?aeaeuaiiy /anoioe na?oeaaeo nei?i/aiue ca
aeaieie AeI AEA, a oaeiae a?ia?o?a?eiiaaiai?y, a?iiaeueoaoieanoa?eiai?y
? i?aeaeuaiiy ??aiy ON EIIU.

?acoeueoaoe iaoeiaeo aeine?aeaeaiue ai?iaaaeaeai? a i?aeoeeo ?inoeoooo
oa?ai?? AII Oe?a?ie, i. Oa?e?a oa e?eoaaeueieo caeeaae?a Oa?e?anueei?
iaeano? (Aiaiaeoo?anueea oa ?cthinueea oeaio?aeuei? ?aeiii? e?ea?i?)

Iniaenoee aianie caeiaoaa/a. Cae?eniaii a?aea?? oaiaoe/ieo oai?eo c
iiaeaeueoei ?oi?i anaa?/iei ianoaaeaiiyi oa niinoa?aaeaiiyi a oiae?
oa?ai??. Aeeiiaii ?ino?oiaioaeueia oa a?io?i?/ia ianoaaeaiiy oai?eo: AeI
AEA, aecia/aiiy eiioeaio?aoe?? o ieaci? e?ia? caaaeueiiai oieanoa?eio
(CON), oieanoa?eio e?iii?ioa?ae?a aeniei? u?eueiino? (ON EIAU), OA
oa?iaioaoeaiei iaoiaeii; OI, OA ? IAeO ?ioiioa?iaioiei iaoiaeii.
I?iaaaeai? iaoaiaoe/ia ia?iaea oa aiae?c io?eiaieo aeaieo.

Ai?iaaoe?y ?iaioe. Iniiai? iieiaeaiiy oa ?acoeueoaoe aeena?oaoe??
iaaiai?ai? ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo ?inoeoooo oa?ai?? AII
Oe?a?ie (1996 — 1998), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
iieiaeeo a/aieo oa oao?aoe?a «No/ani? ooiaeaiaioaeuei? oa i?eeeaaei?
i?iaeaie a ee?i?oe? aioo??oi?o oai?ia» (Oa?e?a, 1997), ia Ia?oiio
i?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a oa iieiaeeo a/aieo
(Oa?iii?eue, 1997).

Ii iaoa??aeai aeena?oaoe?? iioae?eiaaii 6 ?ia?o a oeaio?aeueiiio
ae?ooe?.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 157 noi??ieao,
aeeth/a? anooi, ?icae?e iaeyaeo e?oa?aoo?e c aeaio i?ae?icae?e?a,
?icae?e aeanieo niinoa?aaeaiue c 8 i?ae?icae?e?a, aiae?c ? ocaaaeueiaiiy
io?eiaieo ?acoeueoao?a, aeniiaee ? i?aeoe/i? ?aeiiaiaeaoe??, nienie
aeei?enoaieo aeaea?ae c 219 iaeiaioaaiue, ui neeaaea? 23 noi??iee.
?iaioa i?noeoue 37 oaaeeoeue oa 2 iaethiee.

INIIAIA *ANOEIA

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. I?e aeeiiaii? ?iaioe ianoaaeaii 106
oai?eo ?ON, ui e?eoaaeeny a niaoe?ae?ciaaiiio a?aeae?eaii? aeey oai?eo
?ioa?eoii i?iea?aea ?inoeoooo oa?ai?? AII Oe?a?ie. Aei ?o /enea aoiaeeei
57 oai?eo ia IN a?eii a?ae 28 aei 69 ?ie?a, na?aaei?e a?e yeeo neeaaeaa
(51,11,4) ?ie?a, c ieo 52 (91,2%) /ieia?e?a; 49 oai?eo ia noaa?eueio
noaiiea?ae?th (NN) iai?oae oa niieith II-IV ooieoe?iiaeueieo eean?a a
a?oe? a?ae 31 aei 68 ?ie?a, na?aaei?e a?e neeaaeaa (54,31,8) ?ie?a, c
ieo 45 (92%) /ieia?e?a, oa 21 i?aeoe/ii caei?iaeo in?a (17 /ieia?e?a ?
4 ae?iee), ui neeaaeaee eiio?ieueio a?oio, na?aaei?e a?e yeeo
aei??aithaaa (52,21,9) ?ie?a. Ae?aaiic ?ON anoaiiaethaaee ia i?aenoaa?
ee?i?/ieo aeaieo, eiiieaeno eaai?aoi?ieo ? ?ino?oiaioaeueieo cania?a
aeine?aeaeaiiy, ui aeeth/aa AEA a niiei?, i?iao c aeiciaaiei o?ce/iei
iaaaioaaeaiiyi, AeI AEA. Iii?oi?oaaiiy AEA i?iaiaeeeiny ia a?o/eciyiiio
ea?ae?iaiae?caoi?? «Eaioa-IO» oa ca aeiiiiiaith ii?oaoeaiiai iii?oi?o
o??ie «Kontron instruments». Ianya o?ce/ii? aeoeaiino? aecia/aany
?iaeea?aeoaeueii aeey eiaeiiai oai?iai. Ci?iaie ?oai?/iiai oa?aeoa?o
aaaaeaee o?aiceoi?io aeai?an?th naaiaioa ST ai?eciioaeueiiai aai
iaane?niiieno?aeiiai oa?aeoa?o ia 1 ii ? a?eueoa, a oaeiae eiai
aeaaaoe?th ia 2 ii ? a?eueoa ia a?aenoai? 0,08 nae a?ae oi/ee j oa
o?eaae?noth a?aeoeeaiiy 1 oaeeeia oa a?eueoa.

Aeey i?iaaaeaiiy eaai?aoi?ieo cania?a aeine?aeaeaiiy e?ia caae?aee
a?aioe?, ia ianooiiee aeaiue i?ney iaaeoiaeaeaiiy oai?iai aei ee?i?ee,
/a?ac 12-18 aiaeei i?ney i?eeiio ?ae?. A?io?i?/ia aeine?aeaeaiiy
e?i?ae?a a ieaci? aeeth/aei aecia/aiiy CON, OA ? ON EIAU oa?iaioaoeaiei
caniaii ia aaoiaiae?caoi?? «Corona» (Oaaoe?y) c aeei?enoaiiyi iaai??a
o??ie» Boehringer Mannheim» (Aa?iai?y-Aano??y).

Ai?no ON e?iii?ioa?ae?a aeoaea iecueei? u?eueiino? (ON EIAeIU), ON
e?iii?ioa?ae?a iecueei? u?eueiino? (ON EIIU) oa eiao?oe??io aoa?iaaiino?
aecia/aee ?ic?aooieiaei iaoiaeii.

Ai?no a e?ia? OI, IAeO, OA aecia/aee ?ioiioa?iaioiei caniaii.
Aeei?enoaee eiia?oe?ei? ?ioiioa?iaioi? oano-nenoaie ae?iaieoeoaa
aeine?aeiiai i?aei?e?inoaa Oeaio?aeueiiai iaoeiai-aeine?aeiiai ?inoeoooo
aaeoeei ? ne?iaaoie ?i. ?. TH. Ia/ieeiaa (Iineianueea iaeanoue, i.
Iao?iai-Aeaeuei?). Aeey iinoaiiaee ?aaeoe?e aeei?enoiaoaaee eiiieaeo
iaeaaeiaiiy aeey ?ioiioa?iaioiiai aiae?co o??ie» Flow»
(Aaeeeia?eoai?y).

Iiaoi?ia ianoaaeaiiy oai?eo aoei aeeiiaii /a?ac 8 ?ie?a.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Io?eiai? i?e aiae?c? AeI
AEA ?acoeueoaoe na?ae/aoue i?i ia?aaaao «i?ii?» ?oai?? i?iea?aea iaae
aieueiaith i?e ?ON, a?eueo ae?aaeaio i?e aeanoaa?e?caoe?? ia?aa?ao ?ON.
Iciaee ?oai?? i?iea?aea aeyaeai? a on?o 57 oai?eo ia IN, i?e/iio
ai?ciaee I?I niinoa??aaeeny /ano?oa o oai?eo ia IN (o 75 % oai?eo), i?ae
o oai?eo ia NN (o 57 % oai?eo), (?0,05).

Iaea?eueo /anoi I?I cono??/aeany i?e iayaiino? oaeeo oaeoi??a ?eceeo ?ON
ye oeoe?iaee ae?aaao (o 90,9 % oai?eo ia IN ?c oeoe?iaei ae?aaaoii),
a?oa??aeueia a?ia?oaic?y (o 85,7 % oai?eo ia NN oa o 81,1 % oai?eo ia
IN). Aeyaeaia oaeiae a?eueoa /anoioa aeieeiaiiy ai?ciae?a I?I o oai?eo
ia IC ? NN ?c iino?ioa?eoiei ea?ae?ineea?icii o ii??aiyii? c oai?eie aac
iueiai: 82,5% oa 78% a?aeiia?aeii.

Ii i??? c?inoaiiy oyaeeino? oa o?eaaeino? ia?aa?ao ?ON niinoa??aaeiny
ca?eueoaiiy ieoiiiai /enea, na?aaeiuei? oa noia?ii? o?eaaeino? I?I
(oaaeeoey 1). I?aeoaa?aeaeaiiyi oeueiio ? iaeiaioa /anoioa I?I o oai?eo
ia noaiiea?ae?th, ui aia?oa aeieeea, a oaeiae ca?eueoaiiy e?eueeino?
?oai?/ieo ai?ciae?a, i?e/iio a a?eueoiio nooiai? ca ?aooiie I?I, ii i???
c?inoaiiy ooieoe?iiaeueiiai eeano NN. Niinoa??aaeany ia?aaaaa ai?ciae?a
aeai?an?? naaiaioa ST i?e an?o ee?i?/ieo oi?iao ?ON, ca aeiyoeii oai?eo
ia niiioaiio noaiiea?ae?th, o yeeo iniiaio iano ai?ciae?a ci?uaiiy
naaiaioa ST neeaaeaee ai?ciaee eiai aeaaaoe??. Aeyaeaia ca?eueoaiiy
ieoiii? aaae ai?ciae?a aeai?an?? naaiaioa ST a caaaeuei?e no?oeoo??
?oai?/ieo ii?ooaiue i?e c?inoaii? oyaeeino? caoai?thaaiiy iiaea aooe
iiyniaia a?eueoei nooiaiai aoa?ineea?ioe/iiai o?aaeaiiy ei?iia?ieo
a?oa??e.

I?ioa ii i??? ca?eueoaiiy ooieoe?iiaeueiiai eeano (OE) niinoa??aaeiny
ca?eueoaiiy aaniethoii? e?eueeino? aeaaaoe?e naaiaioa ST, ui iiaeia
iiynieoe e?eueeiia i?e/eiaie. Ii-ia?oa, i?ae /an niiioaiieo ai?ciae?a
?oai?? inoaiiy iineoue o?ainio?aeueiee oa?aeoa?, ui ? i?iyaey?oueny
aeaaaoe??th naaiaioa ST. Eia?/ii i?eionoeoe, ui i?e aeueo OE
?iia??i?noue ai?ciae?a o?ainio?aeueii? ?oai?? a?eueoa. Ii-ae?oaa,
aia?ia?ao?/ii aeaaaoe?y naaiaioo ST /anoi noi?iaiaeaeo? oioaeueio
ieethc?th a?aeiia?aeii? noaeeie, a oie /an ye o oai?eo c aeai?an??th
naaiaioa ST aeyaey?oueny aeeoocia caoaeaiiy noaeei ?c iaiiaiith
ieethc??th aai ae ieethc?y a?eueo ae??aieo noaeei. I?e aiae?c?
na?aaeiuei? o?eaaeino? ?oai?/iiai ai?ciaeo anoaiiaeaii, ui iaea?eueo
ei?ioe? ?oai?/i? aoaee cono??/aeeny o oai?eo ia niiioaiio noaiiea?ae?th
— (1,91,6) oaeeei, a iaea?eueo o?eaae? — o oai?eo ia i?ia?anoth/o
noaiiea?ae?th iai?oae — (5,82,7) oaeeei. NO I?I aoea i?i?iaeueiith o

Oaaeeoey 1 — Iciaee o?aiceoi?ii? ?oai?? i?iea?aea o oai?eo ia IN ? NN
ca aeaieie aeiaiaiai iii?oi?oaaiiy AEA, (Mm)

Oai?? ia IN (n=57)Oai?? ia NN (n=49)Oa?aeoa?enoeea ai?ciae?a ?oai??
i?iea?aeaI?ia?anoth/a noaiiea?ae?y iai?oae (n=43)Noaiiea?ae?y, ui aia?oa
aeieeea (n=9)Niiioaiia noaiiea?ae?y

(n=5)II OE

(n=10)III OE

(n=26)IV OE

(n=13)E?euee?noue ai?ciae?a aeaaaoe?? naaiaioa ST ca aeiao2,10,9*3,10,
9*9,92, 20,30, 22,30,6***2,71, 1***-o oiio /ene? I?I, a % a?ae
caaaeueii? e?eueeino? ai?ciae?a56*69*95827274E?euee?noue ai?ciae?a
aeai?an?? naaiaioa ST ca aeiao10,92, 44,71,9 **1,20,2 **2,50, 57,41,0
***10,22,1 ***-o oiio /ene? I?I, a % a?ae caaaeueii? e?eueeino?
ai?ciae?a777489526769

I?ei?oee:

1. * — a?aei?iiino? a??ia?aei? (p<0, 05) o ii??aiyii? c a?oiith oai?eo ia niiioaiio noaiiea?ae?th 2. ** - a?aei?iiino? a??ia?aei? o ii??aiyii? c a?oiith oai?eo ia i?ia?anoth/o noaiiea?ae?th iai?oae (p<0, 001); 3. ***- a?aei?iiino? a??ia?aei? o ii??aiyii? c oai?eie ia NN II ooieoe?iiaeueiiai eeano (p<0, 001) oai?eo ia noaiiea?ae?th, ui aia?oa aeieeea: (15,92,1) oaeeei, a iaeneiaeueiith - o oai?eo ia i?ia?anoth/o noaiiea?ae?th iai?oae (34,14,9) oaeeei, ( p<0,05).Ca?aeii io?eiaieo aeaieo, na?aaeiy o?eaae?noue iaeiiai ai?ciaeo aieueiai? ?oai?? i?iea?aea (A?I) a??ia?aeii ia?aaeuoaaea na?aaeith o?eaae?noue ai?ciaeo I?I ye i?e IN, oae ? i?e NN, ? neeaaeaea i?e IN (7,81,12) oaeeei aeey A?I i?ioe (4,3 0,85) oaeeei aeey I?I, (? 0,05), ? i?e NN (6,061,21) oaeeei i?ioe (3,070,7) oaeeei (?<0,05) a?aeiia?aeii. Aeyaeaii iaai? a?aei?iiino? a iaoiaaiaoe/ieo iaoai?ciao, ui eaaeaoue a iniia? aeieeiaiiy I?I, i?e noaa?eueiiio ia?aa?ao ?ON ? i?e ?? aeanoaa?e?caoe??. Ia?aaaaeia a?eueo?noue ye aieueiaeo, oae ? “i?ieo” ai?ciae?a ?oai?? i?iea?aea o oai?eo ia IN ? NN, ui ia?aa?aathoue c aeaaaoe??th naaiaioa ST, aeieeaea i?e iaci?ii?e *NN. Aieueia? ai?ciaee aeai?an?? naaiaioa ST i?e IN oa i?e NN, oaeiae ye ? a?eueo?noue "i?ieo" aeai?an?e naaiaioa ST i?e NN ia?aa?aaee ia oe? i?aeaeuaiiy *NN. A oie aea /an iiaeia i?eionoeoe, ui “i?i?” ai?ciaee aeai?an?? naaiaioa ST o oai?eo ia IN coiiaeai? ia?aeiiith ?aaeoeoe??th ei?iia?iiai e?iaiia?ao, ine?eueee aeieeaee ia oe? iaci?iii? *NN. Aeyaeai? a?aei?iiino? a iaoiaaiac? I?I i?e NN oa IN i?aeoaa?aeaeothoueny ? ??cieoeath a oee?eaaei?e ia??iaee/iino? ai?ciae?a I?I: i?e IN I?I cono??/athoueny /ano?oa aii/?, eiee iio?aaa i?iea?aea a eeni? iaaaeeea, a i?e NN ai?ciaee I?I niinoa??aathoueny /ano?oa a aeaiiee /an ? i?e i?iaoaeaeaii? oai?eo, eiee iio?aaa i?iea?aea a eeni? c?inoa? aiane?aeie i?aeaeuaiiy a?oa??aeueiiai oeneo, *NN oa nei?i/oaaeueii? ni?iiiaeiino? i?iea?aea. Aeyaeaii iiaeeaeaiiy ii?ooaiue e?i?aeiiai iai?io i?e aeanoaa?e?caoe?? ia?aa?ao noaiiea?ae??, iaea?eueo /?oei ae?aaeaia i?e i?ia?anoth/?e noaiiea?ae?? iai?oae. Aea/aiiy caeaaeiino? e?i?aeiiai iai?io a?ae iayaiino? aieueiaiai neiae?iio iieacaei, ui aeey oai?eo c aeiyoeiai aacaieueiaeie ci?uaiiyie naaiaioa ST (n=6) ia a?aei?ii?noue a?ae oai?eo, ui iaee o?eueee aieueia? ai?ciaee ?oai?? i?iea?aea (n=14), aoa oa?aeoa?iee a?eueo iecueeee ai?no aioeaoa?iaaieo EIAU (38,7 0,3) ia/aee oa (42,2 0,7) ia/aee a?aeiia?aeii, (p < 0,001). Ii?ooaiiy e?i?aeiiai iai?io o oai?eo ia IN aoee a?eueo ae?aaeai? a a?oi? ?c NO I?I iiiaae 60 oaeeei/24 aiaeeie (n=18) a ii??aiyii? ?c a?oiith oai?eo ?c NO I?I iaioa 60 oaeeei/24 aiaeeie (n=25), iaeiae a??ia?aeiei aoei o?eueee i?aeaeuaiiy ON EIIU i?e NO I?I iiiaae 60 oaeeei/24 aiaeeie: (175,54,6) ia/aee ? (149,7 7,6) ia/aee a?aeiia?aeii, (p < 0,05). Aeyaeaia o?nia i?yia caeaaei?noue i?ae ??aiai CON, OA ? na?aaeiueith e?euee?noth ai?ciae?a I?I ca aeiao (r=+0,76; p < 0,05) ? (r=+0,79; p<0, 05) a?aeiia?aeii. A??ia?aeii? ei?aeyoe?? oeo aea iieaciee?a e?i?aeiiai iai?io c /anoioith aieueiaeo ai?ciae?a ?oai?? i?iea?aea ia aeyaeaii. Iieacaii iaaaoeaio ei?aeyoe?th ??aiy EIAU ?c o?eaae?noth I?I (r=-0,72; ? < 0,01), i?yio caeaaei?noue i?ae NO I?I ? ON EIIU (r=0,87, ? < 0,01). Io?eiai? ?acoeueoaoe iiaeia iiynieoe oei, ui EIAU noeioeththoue ooai?aiiy i?inoaoeeee?io ? ioaea cao?eiothoue aa?aaaoe?th o?iiaioeeo?a, ?iaea??othoue ?iaeoeiaaio EIIU (/a?ac oinoao?ae?e-?iiceoiee oeeee) aeoeaaoe?th o?iiaioeeo?a, a aii A-I, iniiaiee a?eie EIAU, noaa?e?co? ieaciiaee i?inoaoeeee?i ? aeoeao? o?a?eiie?c. A?aoiaoth/e iiaeeea? a?aei?iiino? a iaoiaaiac? “i?ieo” ai?ciae?a ?oai?? i?iea?aea, ui ia?aa?aathoue c a??ia?aeiei i?e?inoii *NN ? aac iueiai, oai?eo ia IN c ai?ciaeaie I?I aoei iiae?eaii ia 2 a?oie: I a?oio (n=32) neeaee oai??, o yeeo a?eueo?noue ai?ciae?a I?I (iiiaae 50% a?ae caaaeueii? e?eueeino? ai?ciae?a) ?icaeaaeany aac a??ia?aeiiai i?e?inoo *NN ia /an ?icaeoeo ?oai?/iiai ai?ciaeo; II a?oio (n=11) neeaee oai??, o yeeo a?eueoino? ai?ciae?a I?I ia?aaeoaaei a??ia?aeia i?aeaeuaiiy *NN ca aeaieie AeI AEA. O oai?eo ia IN eiioeaio?aoe?? CON, OA ? ON EIIU aoee a??ia?aeii aeua a II a?oi? oai?eo (oaaeeoey 2). Oaaeeoey 2 - Iieacieee e?i?aeiiai iai?io ? ieaciiai? eaiee aaiinoaco o oai?eo ia IN c ai?ciaeaie I?I, ui iathoue ??ci? iaoiaaiaoe/i? iaoai?cie ?? aeieeiaiiy ca aeaieie AeI AEA, (Mm) IieacieeI a?oia (n =32)II a?oia (n=11)CON, ia/aee237,510, 6268,49,2*OA, ia/aee221,37,2246,98,9*ON EIIU, ia/aee148,14,5164,46,8 **ON EIAeIU, ia/aee44,11,645,01,8ON EIAU, ia/aee40,20,739,80,9OI, iea/ie258,421,9325,124,0*IAeO, iea/ie49,82,456,53,1OA, ia/ie5,40,27,70,8*I?ei?oee: 1. *- a??ia?aei?noue a?aei?iiinoae ?0,05; 2.** - a??ia?aei?noue a?aei?iiinoae ?0, 01. sse a?aeiii, o oai?eo ia ?ON c ii?ooaiiyie e?i?aeiiai iai?io a?aecia/a?oueny a?eueo iai?oaeaiee, iaaoaeoeaiee ?aaeei ?iaioe i?iea?aea o ii??aiyii? c oai?eie c ii?iie?i?aeai??th. I?e/aoi?noue ca?eueoaiiai ??aiy ON EIIU aei ai?ciae?a I?I iaaacinianoe/iiai aaiaco o ianoaaeaieo oai?eo iiynith?oueny oei, ui a oiiaao a?ia?oieanoa?eiai?? ooai?ai? ii ia?eoa??? eai?ey?iiai e?iaioieo oieanoa?eiiaee oa e?iii?ioa?aeiee aa?'??e oneeaaeiththoue aeinoaaeo eenith aei i?iea?aea oa eiai aeeooc?th aei oeaieie na?oeaaiai i'yca, iniaeeai ca oiiae c?inoaiiy ?? iio?aa o eeni? (a oiio /ene? ? i?e i?aeaeuaii? *NN). A?aoiaoth/e ?ieue eiaaoeyoe?eieo oaeoi??a e?ia? a aeanoaa?e?caoe?? ia?aa?ao ?ON oa ?oith iiaeeeao ?ieue a aaiac? ai?ciae?a o?aiceoi?ii? ?oai?? i?iea?aea, a oiio /ene? ? I?I, aoee aea/ai? aeaye? iieacieee ieaciiai? eaiee aaiinoaco o oai?eo ia IN c ??cieie aa??aioaie aieueiaiai neiae?iio. Aeyaeaii, ui ci?ie iieaciee?a ieaciiai? eaiee aaiinoaco ia caeaaeaoue a?ae oa?aeoa?o ?oai?? i?iea?aea, i?i ui na?ae/eoue a?aenooi?noue a??ia?aeieo a?aei?iiinoae ??aiy OI, OA ? IAeO o in?a c aieueiaith ? aacaieueiaith ?oai??th i?iea?aea, ui iiaea na?ae/eoe i?i ?aei?noue iaoiaaiaoe/ieo iaoai?ci?a “i?ieo” ? aieueiaeo ai?ciae?a o?aiceoi?ii? ?oai?? i?iea?aea. Aeyaeaii ca'ycie i?ae iieacieeaie aaiinoaco, ui aea/aee, ? o?eaae?noth I?I: o oai?eo c NO I?I iiiaae 60 oaeeei/24 aiaeeie (n=18) a ii??aiyii? ?c oai?ei ui iaee NO I?I iaioa 60 oaeeei/24 aiaeeie (n=25) iaei i?noea a??ia?aeia cieaeaiiy eiioeaio?aoe?? OA (4,70,7) ia/ie i?ioe (7,31,1) ia/ie, (?<0,05) ? OI (242,112,1) iea/ie i?ioe (283,117,8) iea/ie (?<0,05) i?e a?aenooiino? a??ia?aeieo ci?i ai?noo IAeO. Cieaeaiiy eiioeaio?aoe?? OI o oai?eo ia IN ?c NO I?I iiiaae 60 oaeeei/24 aiaeeie aeicaiey? iiynieoe ciaeaeaia ciaioaiiy ai?noo OA aac a?aeiia?aeiiai i?e?inoo IAeO oaeei /eiii: i?e iaoieia?/i?e aeoeaaoe?? cai?oath/i? nenoaie e?ia?, iiya? a e?iaiiiniiio ?one? aa?aaao?a o?a?eia, IAeO a?aeaoaa?oueny ca'ycoaaiiy o?a?iiaeoeia ?c iiaeaeueoith ooee?caoe??th aa?aaao?a ?aoeeoeiaiaeioae?aeueiith nenoaiith. A?aenooi?noue iii?oii? aeeiai?ee IAeO iiaea iai?yiei oeyoii na?ae/eoe i?i cieaeaiiy o?a?eiie?oe/ii? aeoeaiino? e?ia? o oai?eo ia IN ?c cia/iith I?I. Aoa i?iaaaeaiee aiae?c iieaciee?a nenoaie cai?oaiiy e?ia? o oai?eo ia IN c ??cieie iiaeeeaeie iaoiaaiaoe/ieie iaoai?ciaie I?I ca aeaieie AeI AEA (oaaeeoey 2). I?e oeueiio aeyaeaii, ui a I a?oi? oai?eo a ii??aiyii? ?c II a?oiith a?aeaoaaeiny a??ia?aeia ciaioaiiy ??ai?a OI oa OA i?e a?aenooiino? cia/ieo ci?i IAeO, ui na?ae/eoue i?i aeoeaaoe?th nenoaie cai?oaiiy e?ia? ia oe? cieaeaiiy ?? o?a?eiie?oe/ii? aeoeaiino? ? iiaea ?icaeyaeaoeny ye i?e/eia i?eiaeii? /anoeie ai?ciae?a I?I o oai?eo ia IN. Ei?aeyoe?eiee aiae?c iieaciee?a ieaciiai? nenoaie aaiinoaco ? ia?aiao??a I?I i?aeoaa?aeea iiaeeeao ?ieue i?aeaeuaiiy oaeoi??a cai?oaiiy e?ia? a aaiac? ai?ciae?a I?I o oai?eo ia IN: aeyaeaii iaaaoeaio ei?aeyoe?th i?ae ??aiai OI ? NO I?I (r=-0, 54, p<0, 05), a oaeiae i?ae ai?noii OA a ieaci? e?ia? ? NO I?I (r= -0, 61, p<0,05) i?e a?aenooiino? ei?aeyoe?? i?ae iaaaaeaieie aeua iieacieeaie ? e?euee?noth ai?ciae?a I?I. Aeey aea/aiiy aoaeoeaiino? ??cieo a?oi aioeaia?iaeueieo i?aia?ao?a o oai?eo ia IN c ai?ciaeaie “i?ii?” ?oai?? i?iea?aea oai?? ia IN aoee ?iciiae?eai? ii 3 a?oiai: I a?oio (n=12) neeaee oai??, ui iaea?aeoaaee oa?ai?th i?aia?aoaie i?ieiiaiaaiiai i?o?iaeeoea?eia (nonoae 6,4 ia 4-6 ?ac?a ia aeiao); a II a?oio (n=15) aa?eoee oai??, ui iaea?aeoaaee eiia?iiaaio oa?ai?th i?ieiiaiaaieie i?o?aoaie ? aaoa-aae?aiiaeieaoi?ii aoaiieieii a aeic? 25-50 ia 2 ?ace ia aeiao ? III a?oio (n=10) neeaee oai??, ui i?eeiaee ie??i i?ieiiaiaaieo i?o?ii?aia?ao?a aioaaii?no eaeueoe?th ae?eo?acai a aeic? 60 ia 3-4 ?ace ia aeiao (oaaeeoey 3). An? oai?? io?eioaaee ani??ei a aeic? 125 ia ia aeiao. Oa?ai?y i?ieiiaiaaieie i?o?aoaie, iacaaaeath/e ia iii?oiee aioeaia?iaeueiee aoaeo, ui iieyaaa a ciaioaii? e?eueeino? ? o?eaaeino? i?enooi?a noaiiea?ae?? ? iiceoeaiee aieea ia aeaye? iieacieee ieaciiai? eaiee aaiieiaaoeyoe??, ui aeyaeyeiny a a??ia?aeiiio cieaeaii? ??aiy OA, ia iaea nooo?aiai aieeao ia I?I. O oai?eo, ui iaea?aeoaaee eiia?iiaaio oa?ai?th i?o?ii?aia?aoaie ? aaoa-aae?aiiaeieaoi?ii aoaiieieii, niinoa??aaany nooo?aee aioeaia?iaeuei?e aoaeo, ui aeyaeyany a a??ia?aeiiio cieaeaii? e?eueeino? aia?iicieo i?enooi?a c (5,50,9) aei (2,00,3), ?0,01, i?e oeueiio ia a?aei?ii?noue a?ae oai?eo I a?oie a?aeaoaaeiny cia/ia ciaioaiiy e?eueeino? ai?ciae?a I?I. Aeaia eiia?iaoe?y aoaeoeaii cieaeoaaea na?aaeith o?eaae?noue ye aieueiaeo, oae ? “i?ieo” ai?ciae?a ?oai?? i?iea?aea. A?aoiaoth/e a?aenooi?noue a??ia?aeiiai aieeao iiiioa?ai?? i?o?aoaie ia iieacieee AeI AEA, ui oa?aeoa?ecothoue I?I, aoaeo eiia?iiaaii? oa?ai?? i?o?aoaie ? aaoa-aae?aiiaeieaoi?ii aoaiieieii eia?/ii iiynieoe aieeaii naia aoaiieieo. I?e ioe?ioe? aoaeoeaiino? ii?aeiaiiai canoinoaaiiy i?ieiiaiaaieo i?o?ii?aia?ao?a ? aioaaii?noa eaeueoe?th ae?eo?acaia oaeiae niinoa??aaeiny iii?oia ciaioaiiy e?eueeino? aieueiaeo ? “i?ieo” ai?ciae?a ?oai?? i?iea?aea. Oaeith ae aoaeoeaiith aeyaeeany aeaia eiia?iaoe?y ? a?aeiinii ciaioaiiy na?aaeiuei? o?eaaeino? ?oai?/iiai ai?ciaeo: a?aeaoaaeiny a??ia?aeia ciaioaiiy na?aaeiuei? o?eaaeino? ye aieueiaeo, oae ? aacaieueiaeo ai?ciae?a ?oai?? i?iea?aea, aiane?aeie /iai ciaiooaaeeny ? NO I?I ? NO A?I. Oe?eaai a?aecia/eoe oie oaeo, ui oi/a iaeaea? eiia?iaoe?? aeyaeeeny aeinoaoiuei aoaeoeaieie o a?aeiioaii? I?I, aoee ? aeaye? a?aei?iiino?. O oai?eo II a?oie, ui iaea?aeoaaee aoaiieie, a?aecia/aany a?eueo iii?oiee iaaaoeaiee o?iiio?iiiee aoaeo: na?aaeiy *NN a??ia?aeii ciaiooaaeany c (73,5 2,4) aei (65,12,1) ca oaeeeio, p<0,05. I?ae aieeaii ae?eo?acaia o oai?eo III a?oie a??ia?aeiiai ciaioaiiy na?aaeiuei? *NN ia niinoa??aaeiny. Iaeaeaa i?aia?aoe iaee ? aeaye? iniaeeaino? aioe?oai?/ii? ae??. A a?oi? oai?eo, ui i?eeiaee aoaiieie, niinoa??aaany a?eueoee aoaeo o a?aeiioaii? aeai?an?e naaiaioa ST: e?euee?noue aeai?an?e naaiaioa ST ca aeiao ciaioeeany c (8,41,7) aei (2,00,3), (p<0,001), oiae? ye ciaioaiiy e?eueeino? ai?ciae?a aeaaaoe?e naaiaioa ST aoei iaa??ia?aeiei. Ae?eo?acai a?eueo aeoeaii aieeaaa ia ai?ciaee I?I, ye? ia?aa?aaee c aeaaaoe??th naaiaioa ST: e?euee?noue “i?ieo” aeaaaoe?e naaiaioo ST ca aeiao ciaioeeany c (3,20,3) aei (1,30,1), (p<0,001), ci?ie e?eueeino? aeai?an?e naaiaioa ST aoee iaa??ia?aeieie. Canoinoaaiiy ia oe? i?o?ao?a aoaiieiea aai ae?eo?acaia aeeeeeaei ?yae iiceoeaieo c?ooaiue a ieaciia?e eaioe? aaiinoaco, a naia ciaioaiiy ??aiy IAeO ? i?aeaeuaiiy ??aiy OI a?aeiia?aeii, i?e oeueiio aeiaeai c oeeo i?aia?ao?a ia i?ioyc? o?ueio oeaei?a oa?ai?? ia aeeeeeaa a??ia?aeieo ii?ooaiue e?i?aeiiai iai?io o oai?eo ia IN. Oaaeeoey 3 - Iieacieee AeI AEA o oai?eo ia IN c "i?iith" ?oai??th i?iea?aea a aeeiai?oe? aioeaia?iaeueii? oa?ai??, (Mm) I a?oia (n=12) II a?oia (n=15) III a?oia (n=10) IieacieeAeiI?neyAeiI?neyAeiI?neyE?euee?noue aieueiaeo ai?ciae?a ?oai?? ca aeiao5,30,62,80,4**5,50,92,00,3**6,11,02,50,8*E?euee?noue "i?ieo" ai?ciae?a ?oai?? ca aeiao9,82,47,91,910,22,03,20,8**10,32,74,01,0*Na?aaeiy o?eaae?noue aieueiaiai ai?ciaeo ?oai?? i?iea?aea, oaeeei7,21,03,60,5**7,51,03,10,8**6,81,03,00,3**Na?aaeiy o?eaae?noue "i?iiai" ai?ciaeo ?oai?? i?iea?aea, oaeeei4,30,94,20,84,90,92,10,5*3,90,72,10,3*Noia?ia o?eaae?noue aieueiai? ?oai?? i?iea?aea, oaeeei/24 aiaeeie34,92,09,21,538,72,27,11,340,90,77,91,3Noia?ia o?eaae?noue "i?ii?" ?oai?? i?iea?aea, oaeeei/24 aiaeeie41,02,833,73,141,83,07,41,445,24,88,82,0 I?ei?oee: 1. * - a??ia?aei?noue a?aei?iiinoae iieaciee?a a iaaeao iaei??? ? o??? ae a?oie aei ? i?ney e?eoaaiiy p<0, 05; 2. ** - a??ia?aei?noue a?aei?iiinoae iieaciee?a a iaaeao iaei??? ? o??? ae a?oie aei ? i?ney e?eoaaiiy p<0, 01; 3. - a??ia?aei?noue a?aei?iiinoae iieaciee?a a iaaeao iaei??? ? o??? ae a?oie aei ? i?ney e?eoaaiiy p< 0,001. Oai?? ia IN c iani?eyoeeaei iaeaeeae/ei ia?aa?aii oai?iae (n=19) (i?aeaeuaiiy ooieoe?iiaeueiiai eeano noaiiea?ae??, ?icaeoie ?ioa?eoo i?iea?aea, a oiio /ene? ? oaoaeueiiai) iaee ?yae ?noioieo a?aei?iiinoae a?ae oai?eo ?c ni?eyoeeaei ia?aa?aii (n=38) a i?iyaao aia?iiciiai neiae?iio, a naia a?eueo /ano?, c i?i?iaeueiei aacaia?iiciei ?ioa?aaeii iaio 1 aiaeeie, ? caoyaei?, a?eueo 15 oaeeei, i?enooie noaiiea?ae??. Anoaiiaeaii, ui iayai?noue NO I?I a?eueo 60 oaeeei ca 24 aiaeeie ? aenieiniaoeeo?/iei ? aeniei/ooeeaei e?eoa???i ?aiiueiai iani?eyoeeaiai i?iaiico i?e IN. I?e oeueiio o oai?eo c iani?eyoeeaei ia?aa?aii IN niinoa??aaeeny a?eueo? “aoa?iaaii?” ii?ooaiiy a e?i?aeiiio iai?i?, ui aeyaeyeiny a ca?eueoaii? ai?noo ON EIIU a?ae (151,8 3,9) ia/aee aei (166,44,5) ia/aee, (?0,05), ? cieaeaii? ai?noo ON EIAU a?ae (42,7 1,2) ia/aee aei (38,90,9) ia/aee, (p<0,05). I?e aea/aii? iieaciee?a, ui oa?aeoa?ecothoue oaeoi?e cai?oaiiy e?ia?, o oai?eo ia IN i?e iani?eyoeeaiio ia?aa?ao caoai?thaaiiy ii??aiyii c aeia?iye?niei ia?aa?aii aeyaeaii cieaeaiiy ??aiy OI oa ??aiy OA: (271,78,7) iea/ie i?ioe (324,54,0) iea/ie (p<0,05) oa (5,80,6) a/e i?ioe (7,70,6) a/e (p<0,05) a?aeiia?aeii i?e a?aenooiino? a??ia?aeieo ci?i IAeO. Aoei i?iaaaeaii aea/aiiy aieeao I?I ia a?aeaeaeaiee i?iaiic oai?eo ia IN, aeey /iai oai?eo ia IN aoei iiae?eaii ia a?oie a caeaaeiino? a?ae iayaiino? aieueiaiai neiae?iio ia iiiaio aeaoooy c noaoe?iia?o: I a?oio (n=9) neeaee oai??, ui iaee o?eueee aieueia? ai?ciaee ?oai?? i?iea?aea ; II a?oiio (n=12) neeaee oai??, ui iaee ai?ciaee I?I, aei III a?oie (n=5) oa?eoee oai?? aac ai?ciae?a ?oai?? i?iea?aea. Io?eiai? ?acoeueoaoe iieacothoue, ui iayai?noue I?I ia oe? aioeaia?iaeueii? oa?ai?? ? aaaeeeaei i?aaeeeoi?ii iani?eyoeeaeo ea?ae?aeueieo iiae?e: a I a?oi? "aaeee? ea?ae?aeuei? iiae??" iaee i?noea o 33 % oai?eo, a a II a?oi? - o 75% oai?eo, p<0,05; a III a?oi? /anoioa "aaeeeeo ea?ae?aeueieo iiae?e" nooo?ai ia a?ae??ciyeany ? neeaaeaea 40%. A caeaaeiino? a?ae a?aeaeaeaiiai ?acoeueoaoo oai?? ia IN aoee iiae?eai? ia 3 a?oie. I a?oio neeaee 14 oai?eo, ui iaee “aaeee? ea?ae?aeuei? iiae??” - ei?iia?io nia?oue aai iaoaoaeueiee ?ioa?eo i?iea?aea, a II a?oio aa?eoee 5 oai?eo, o yeeo ia?aa?a caoai?thaaiiy aoa noaa?eueiei, ? III a?oio (n=7) neeaee oai?? c i?ia?anoth/ei ia?aa?aii caoai?thaaiiy. *anoioa aeyaeaiiy I?I o oai?eo o?ueio a?oi a?ae??ciyeany: a I a?oi? ai?ciaee I?I ?a?no?oaaeeny o 64,3 % oai?eo, a oie /an ye o oai?eo II a?oie ai?ciaee I?I ia ?a?no?oaaeeny. Oai?? III a?oie oaeiae iaee ai?ciaee I?I, iaeiae a?eueo ??aeei o ii??aiyii? ?c oai?eie I a?oie - a 42,9 % aeiaaee?a, i?e/iio a I a?oi? aoea a??ia?aeii a?eueoa NO I?I ca 24 aiaeeie: (16,61,6) oaeeei i?ioe (3,50,2) oaeeei, (?<0,001) a?aeiia?aeii, o oe??? ae eaoaai??? oai?eo iaea i?noea ? a?eueoa aiie?ooaea ci?uaiiy naaiaioa ST (1,9 0,1) ii i?ioe (1,20,2) ii (?<0,05) a?aeiia?aeii. O oai?eo c oneeaaeiaiei ia?aa?aii IN niinoa??aaany ia??aiii??iee ?iciiae?e ai?ciae?a I?I c iaea?eueoith /anoioith a i?/i? ? ?aii? ?aieia? aiaeeie: ca ia??iae c 21 aei 9 aiaeei niinoa??aaeeny 74% an?o ai?ciae?a I?I, i?e/iio iieiaeia an?o ai?ciae?a I?I (49,1%) i?eoiaeeeiny ia ?aii? ?aieia? aiaeeie - c 3 aiaeeie aei 9 aiaeeie. I?e oeueiio o oai?eo, o yeeo ia?aa?a IN oneeaaeieany “aaeeeeie ea?ae?aeueieie iiae?yie”, ai?ciaee I?I aeieeaee cia/ii /ano?oa (78,5% an?o ai?ciae?a) ia oe? iaci?iii? *NN. I?e aiae?c? iieaciee?a eiaaoeyoe?? e?ia? ? e?i?aeiiai niaeo?a e?ia? a??ia?aei? a?aei?iiino? ciaeaeai? o?eueee aeey ai?noo OA, ON EIAU ? ON EIIU (oaaeeoey 4). Oaaeeoey 4 - Iieacieee ieaciiai? eaiee aaiinoaco ? e?i?aeiiai niaeo?a e?ia? o oai?eo ia IN c ??ciei a?aeaeaeaiei ?acoeueoaoii , (Mm) Iieaciee ieaciiai? eaiee aaiinoacoI a?oia (n=14)II a?oia (n=5)III a?oia (n=7)OI, iea/ie329,09,1317,34,0326,18,2OA, a/e5,60,3*4,40,45,20,3IAeO, iea/ie27,51,424,11,226,81,7ION, ia/aee227,44,6216,24,2218,22,2ON EIAU, ia/aee37,70,7*44,60,6**40,70,5***OA, ia/aee192,44,0188,24,8190,72,0ON EIAeIU, ia/aee39,12,337,63,538,71,6ON EIIU, ia/aee196,13,8*167,42,1186,12,9*I?ei?oee: 1. * - a??ia?aei?noue a?aei?iiinoae o ii??aiyii? c II a?oiith ?<0,01; 2. ** - oa ae naia o ii??aiyii? c III a?oiith, ?<0,01; 3. *** - oa ae naia o ii??aiyii? c I a?oiith, ?<0, 01. AENIIAEE 1. Aeanoaa?e?caoe?y ia?aa?ao noaiiea?ae?? oa?aeoa?eco?oueny ca?eueoaiiyi ieoiii? e?eueeino?, na?aaeiuei? ? noia?ii? o?eaaeino? ai?ciae?a I?I; i?e oeueiio ?ieue i?aeaeuaiiy iio?aae i?iea?aea a eeni? a aaiac? a?eueoino? ai?ciae?a I?I iaaaeeea, i?i ui na?ae/aoue ?acoeueoaoe aeiaiaiai iii?oi?oaaiiy AEA. 2. ?nio? ca'ycie i?ae ??aiai e?i?ae?a ieacie e?ia? ? o?eaae?noth "i?ii?" ?oai?? i?iea?aea: NO I?I ca 24 aiaeeie ei?aeth? iaaaoeaii (r= -0,72) c ON EIAU ? iiceoeaii c ON EIIU (r=0, 87). 3. Ci?ie iieaciee?a ieaciiai? eaiee aaiinoaco ia caeaaeaoue a?ae oa?aeoa?o ?oai?? i?iea?aea, i?i ui na?ae/eoue a?aenooi?noue a??ia?aeieo a?aei?iiinoae ??aiy OI, OA ? IAeO o in?a c aieueiaith ? aacaieueiaith ?oai??th i?iea?aea. 4. ?icaeoie ?oai?? i?iea?aea ia oe? iaci?iii? /anoioe na?oeaaeo nei?i/aiue iia'ycaiee ia o?eueee c aaciniaciii, aea oaeiae c aeoeaaoe??th i?ioean?a o?iiaiooai?thaaiiy ia oe? cieaeaiiy o?a?eiie?oe/ii? aeoeaiino?, i?i ui na?ae/eoue ciaioaiiy eiioeaio?aoe?? OI ? OA aac a?aeiia?aeiiai i?e?inoo IAeO. ?nio? ca'ycie i?ae o?eaae?noth I?I oa ci?iaie iieaciee?a ieaciiai? eaiee aaiinoaco: ci?ie oaeoi??a cai?oaiiy e?ia? aoee a?eueoeie i?e NO I?I iiiaae 60 oaeeei/24 aiaeeie. 5. I?e I?I iaea?eueo aoaeoeaiei ? canoinoaaiiy eiia?iaoe?? i?ieiiaiaaieo i?o?ao?a c aaoa-aae?aiiaeieaoi?ii aoaiieieii aai aioaaii?noii eaeueoe?th ae?eo?acaiii, ui caaacia/o? ye aioeaia?iaeueiee, oae ? aioe?oai?/iee aoaeoe o oai?eo ia IN; i?e oeueiio aoaiieie a?eueo aoaeoeaiee a iiia?aaeaeaii? ai?ciae?a I?I, ye? noi?iaiaeaeothoueny aeai?an??th naaiaioa ST, a canoinoaaiiy ae?eo?acaia ni?ey? a?eueo aoaeoeaiiio cieaeaiith e?eueeino? ai?ciae?a I?I, ui ia?aa?aathoue ?c aeaaaoe??th naaiaioa ST. 6. Canoinoaaiiy ia oe? i?o?ao?a aoaiieiea aai ae?eo?acaia aeeeeea? ?yae iiceoeaieo ci?i ieaciiai? eaiee aaiinoaco, a naia ciaioaiiy ??aiy IAeO ? i?aeaeuaiiy ??aiy OI a?aeiia?aeii, i?e/iio aeiaeai c i?aia?ao?a i?e oa?ai?? i?ioyaii o?ueio oeaei?a ia aeeeeeaa a??ia?aeieo c?ooaiue e?i?aeiiai iai?io o oai?eo ia IN. 7. Oaeoi?aie, ye? aecia/athoue iani?eyoeeaee iaeaeeae/ee i?iaiic i?e IN, ?: e?euee?noue i?enooi?a noaiiea?ae??, o?eaae?noue i?i?iaeueiiai aacaia?iiciiai ?ioa?aaeo ? aieueiaiai neiae?iio, a oaeiae NO I?I ca aeiao. 8. Caa?aaeaiiy I?I o oai?eo ia IN, ia oe? oa?ai??, aenieee ??aaiue OA, a?iiaeueoaoieanoa?eiai?y ? i?aeaeuaiiy ??aiy ON EIIU a ieaci? e?ia? nooo?aei /eiii iia??oothoue a?aeaeaeaiee i?iaiic oai?eo ia IN. I?AEOE*I? ?AEIIAIAeAOe?? 1. Oai?ei ia IN iieacaia i?iaaaeaiiy AeI AEA aeey ioe?iee oyaeeino? noaio ? aecia/aiiy i?iaiico. 2. A?aoiaoth/e, ui iayai?noue I?I ?noioiei /eiii aieeaa? ia iaeaeeae/ee ? a?aeaeaeaiee i?iaiic oai?eo ia IN, aeioe?eueii aeeth/aoe aei noaie e?eoaaiiy aaoa-aae?aiiaeieaoi?e (aoaiieie) /e aioaaii?noe eaeueoe?th (ae?eo?acai), i?e oeueiio aoaiieie a?eueo iieacaiee oai?ei c ia?aaaaith ai?ciae?a aeai?an?? ca aeaieie AeI AEA. 3. A?aoiaoth/e iani?eyoeeao i?iaiinoe/io ?ieue a?iiaeueoaoieanoa?eiai?? ? i?aeaeuaiiai ??aiy ON EIIU, oai?ei ia IN iieacaia i?ecia/aiiy a?iie?i?aeai?/ii? oa?ai??. 4. Oai?ei c iciaeaie ia?aeiii? ?aaeoeoe?? i?iea?ae?aeueiiai e?iaiia?ao iieacaia i?ecia/aiiy i?aia?ao?a, ui aieeaathoue ia nenoaio cai?oaiiy e?ia?. Nienie iioae?eiaaieo iaoeiaeo i?aoeue ca oaiith aeena?oaoe?? 1. Aiaoi E.A., Oeaeoeei A.E., *a?iuoia A.A., Oooue E.A. Eeieaeiue niaeo? e?iae o aieueiuo eoaie/aneie aieaciueth na?aeoea i?e "iaiie" eoaiee ieiea?aea // Oe?. ea?aeeie. aeo?iae. - 1998. - N 9. - N.17 - 20. 2. Aiaoi E.A., Oeaeoeei A.E. Oaeoi?u, ii?aaeaeythuea aeeaeaeoee i?iaiic i?e ianoaaeeueiie noaiiea?aeee // Oe?. ea?aeeie. aeo?iae. - 1998. - N 9. - N.11 - 13. 3. Oeaeoeei A.E., *a?iuoia A.A., Aiaoi E.A. I?eiaiaiea noaoeiia aeey ei??aeoeee aeia?oieanoa?eiaiee o iaoeeaioia n eoaie/aneie aieaciueth na?aeoea // Oe?. ea?aeeie. aeo?iae. - 1998. - N 10. - N.5 - 8. 4. Oeaeoeei A.E., Aiaoi E.A. N?aaieoaeueiay ioeaiea aioeaiaeiaeueiie oa?aiee i?e “iaiie” eoaiee ieiea?aea o aieueiuo ianoaaeeueiie noaiiea?aeeae // A?a/aaiay i?aeoeea. - 1998. - N 4. - N.22-25. 5. E?aa/aiei I.A., Aiaoi E.A., Iaeneiiaa I.A., Eiaaeaaneay I.N. Iniaaiiinoe aeeiaieee o?iaiy oea?iiaeoeia e ieiaeiaeia a ino?ii ia?eiaea eioa?eoa ieiea?aea //A?a/aaiay i?aeoeea. - 1998. - N 4. - N. 19 - 21. 6. Aiaoi E.A. “Iaiay” eoaiey ieiea?aea o aieueiuo ianoaaeeueiie noaiiea?aeeae e oaeoi?u naa?ouaaiey e?iae // Iaoa??aee O?O c?caeo oa?aiaao?a Oe?a?ie. - Ee?a. - 1998. - N. 101-103. Aiioaoe?y Aiaoi E.A. "I?ia" ?oai?y i?iea?aea o oai?eo ia ianoaa?eueio noaiiea?ae?th. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i. Oa?e?a, 1999. I?aaenoaaeaio aei caoenoo aeena?oaoe?th i?enay/aii ieoaiith i?aeaeuaiiy aoaeoeaiino? oa?ai?? oai?eo ia ianoaa?eueio noaiiea?ae?th ia i?aenoaa? aea/aiiy iaoiaaiaoe/ieo iaoai?ci?a ? i?iaiinoe/iiai cia/aiiy "i?ii?" ?oai?? i?iea?aea oa ii??aiyeueii? ioe?iee ??cieo noai e?eoaaiiy. Anoaiiaeaii, ui aeanoaa?e?caoe?y ia?aa?ao ?oai?/ii? oai?iae na?oey noi?iaiaeaeo?oueny i?aeaeuaiiyi /anoioe, na?aaeiuei? oa noia?ii? o?eaaeino? "i?ii?" ?oai?? i?iea?aea. Iieacaia ?ieue ii?ooaiue e?i?aeiiai iai?io ? cai?oath/i? nenoaie e?ia? a ?icaeoeo ai?ciae?a "i?ii?" ?oai?? i?iea?aea. Aecia/ai? e?eoa??? iani?eyoeeaiai iaeaeeae/iai ?acoeueoaoo o oai?eo ia ianoaa?eueio noaiiea?ae?th. ?ic?iaeai? aeeoa?aioe?ei? noaie aioeaia?iaeueii? oa?ai?? oai?eo ia ianoaa?eueio noaiiea?ae?th ?c canoinoaaiiyi aaoa-aeieaoi?a aoaiieiea ? aioaaii?noa eaeueoe?th ae?eo?acaia. Iieacaiee iani?eyoeeaee aieea ia?nenooaaiiy "i?ii?" ?oai?? i?iea?aea ia oe? aioeaia?iaeueii? oa?ai?? ? ii?ooaiue e?i?aeiiai iai?io ia a?aeaeaeaiee ?acoeueoao /a?ac 8 ?ie?a. Eeth/ia? neiaa: ianoaa?eueia noaiiea?ae?y, "i?ia" ?oai?y i?iea?aeo, e?i?aeiee iai?i, ieaciiaa eaiea aaiinoaco, aoaiieie, ae?eo?acai, i?iaiic. Aiiioaoeey Aiaoi E.A. "Iaiay" eoaiey ieiea?aea o aieueiuo ianoaaeeueiie noaiiea?aeeae. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey. Oa?ueeianeee iaaeeoeeineee oieaa?neoao, a. Oa?ueeia, 1999. I?aaenoaaeaiiay e caueoa ?aaioa iinayuaia aii?ino iiauoaiey yooaeoeaiinoe ea/aiey aieueiuo ianoaaeeueiie noaiiea?aeeae ia iniiaaiee eco/aiey iaoiaaiaoe/aneeo iaoaieciia e i?iaiinoe/aneiai cia/aiey "iaiie" eoaiee ieiea?aea e n?aaieoaeueiie ioeaiee ?acee/iuo noai ea/aiey. Ianeaaeiaaii 106 aieueiuo eoaie/aneie aieaciueth na?aeoea, ea/eaoeony a niaoeeaeece?iaaiiii eioa?eoiii ioaeaeaiee Einoeoooa oa?aiee AII Oe?aeiu. A eo /enei aioei 57 aieueiuo ianoaaeeueiie noaiiea?aeeae, n?aaeiee aic?ano (51,1 1,4) aiaea e 49 aieueiuo noaaeeueiie noaiiea?aeeae iai?yaeaiey e iieiy II-IV ooieoeeiiaeueiuo eeannia, n?aaeiee aic?ano (54,31,8) eao. Eiio?ieueioth a?oiio ninoaaeee 21 caei?iauo eeoe, n?aaeiee aic?ano (52,21,9) eao. Iaoiaeu ianeaaeiaaiey aeeth/aee nooi/iia iiieoi?e?iaaiea YEA, ii?aaeaeaiea eiioeaio?aoeee a ieacia e?iae iauaai oieanoa?eia, o?eaeeoea?eaeia e oieanoa?eia eeiii?ioaeaeia aunieie ieioiinoe oa?iaioaoeaiui niiniaii n ii?aaeaeaieai eiioeaio?aoeee oieanoa?eia eeiii?ioaeaeia i/aiue ieceie ieioiinoe, oieanoa?eia ieceie ieioiinoe e eiyooeoeeaioa aoa?iaaiiinoe ?an/aoiui iaoiaeii, a oaeaea ii?aaeaeaiea niaea?aeaiey a e?iae oea?eiiiaeoeia, oea?eiiaaia e i?iaeoeoia aeaa?aaeaoeee oea?ei/oea?eiiaaia eiioiioa?iaioiui niiniaii. Iiaoi?iia ianeaaeiaaiea aieueiuo i?iaiaeeeinue /a?ac 8 eao. Onoaiiaeaii, /oi aeanoaaeeecaoeey eoaie/aneie aieacie na?aeoea nii?iaiaeaeaaony oaaee/aieai /anoiou, n?aaeiae e noiia?iie i?iaeieaeeoaeueiinoe "iaiie" eoaiee ieiea?aea. Iieacaia ?ieue ia?ooaiee eeieaeiiai iaiaia a ?acaeoee yieciaeia "iaiie" eoaiee ieiea?aea: o?iaaiue oieanoa?eia eeiii?ioaeaeia aunieie ieioiinoe aue aeinoiaa?ii ieaea o aieueiuo n eciee?iaaiiuie yieciaeaie"iaiie" eoaiee ieiea?aea, o aieueiuo n noiia?iie aeeeoaeueiinoueth "iaiie" eoaiee ieiea?aea nauoa 60 ieioo/24 /ana iaaethaeaeenue iaeaieaa aoa?iaaiiua naeaeae a iieacaoaeyo eeieaeiiai niaeo?a e?iae. Auyaeaia naycue iaaeaeo iieacaoaeyie ieaciaiiiai caaia aaiinoaca e aeeeoaeueiinoueth "iaiie" eoaiee ieiea?aea: i?e noiia?iie aeeeoaeueiinoe "iaiie" eoaiee ieiea?aea nauoa 60 iei/24 /ana iaaethaeaeinue oiaiueoaiea eiioeaio?aoeee oea?iiaeoeia e oea?eiiaaia i?e ionoonoaee aeinoiaa?iuo aeinoiaa?iuo eciaiaiee i?iaeoeoia aeaa?aaeaoeee oea?ei/oea?eiiaaia. Iieacaii, /oi iaoiaaiaoe/aneea iaoaieciu aicieeiiaaiey yieciaeia "iaiie" eoaiee ieiea?aea o aieueiuo ianoaaeeueiie noaiiea?aeeae iaiaeii?iaeiu: o aieueiuo, o eioi?uo yieciaeu "iaiie" eoaiee ieiea?aea aicieeatho ia oiia iiauoaiey /anoiou na?aea/iuo nie?auaiee, iaaethaeathony aieaa au?aaeaiiua naeaeae a iieacaoaeyo eeieaeiiai iaiaia, a i?e ?acaeoee "iaiie" eoaiee ieiea?aea ia oiia iaeciaiaiiie /anoiou na?aea/iuo nie?auaiee iaaethaeaaony nieaeaiea eiioeaio?aoeee oea?eiiaaia e oea?iiaeoeia a ieacia e?iae aac niioonoaothuaai i?e?inoa eiioeaio?aoeee i?iaeoeoia aeaa?aaeaoeee oea?ei/oea?eiiaaia. Ii?aaeaeaiu e?eoa?ee iaaeaaii?eyoiiai ?aiiaai i?iaiica o aieueiuo ianoaaeeueiie noaiiea?aeeae, e eioi?ui ioiinyony iaee/ea "iaiie" eoaiee ieiea?aea noiia?iie i?iaeieaeeoaeueiinoueth nauoa 60 iei/24 /ana, iiauoaiea o?iaiy oieanoa?eia eeiii?ioaeaeia ieceie ieioiinoe e aeiiaeueoaoieanoa?eiaiey, a oaeaea nieaeaiea eiioeaio?aoeee oea?iiaeoeia e oea?eiiaaia i?e ionoonoaee eciaiaiee eiioeaio?aoeee i?iaeoeoia aeaa?aaeaoeee oea?ei/oea?eiiaaia. ?ac?aaioaiu aeeooa?aioee?iaaiiua noaiu aioeaiaeiaeueiie oa?aiee aieueiuo ianoaaeeueiie noaiiea?aeeae n yieciaeaie "iaiie" eoaiee ieiea?aea n i?eiaiaieai aaoa-aeieaoi?a aoaiieiea e aioaaiienoa eaeueoeey aeeeoeacaia. Iieacaii iaaeaaii?eyoiia aeeyiea nio?aiaiey yieciaeia "iaiie" eoaiee ieiea?aea iinea eeeie/aneie noaaeeecaoeee ianoaaeeueiie noaiiea?aeee, i?e/ai noiia?iay i?iaeieaeeoaeueiinoue "iaiie" eoaiee ieiea?aea nauoa 15 iei/24 /ana ieacaeanue i?aaeeeoi?ii "aieueoeo ea?aeeaeueiuo niauoee". Aunieee o?iaaiue oea?eiiaaia, aeiiaeueoaoieanoa?eiaiey e iiauoaiea eiioeaio?aoeee oieanoa?eia eeiii?ioaeaeia ieceie ieioiinoe a ieacia e?iae /aua ano?a/aeenue o aieueiuo ianoaaeeueiie noaiiea?aeeae n iaaeaaii?eyoiui ioaeaeaiiui i?iaiicii. Eeth/aaua neiaa : ianoaaeeueiay noaiiea?aeey, "iaiay" eoaiey ieiea?aea, eeieaeiue iaiai, ieaciaiiia caaii aaiinoaca, aoaiieie, aeeeoeacai, i?iaiic. Summary Bogun L.V. Silent myocardial ischemia in patients with unstable angina. - Manuscript. Thesis for a candidate's degree of medical science by speciality 14.01.11 - cardiology. - Kharkov state medical university, Kharkov, 1999. The dissertation is devoted to enhancing of efficacy of treatment of the patients with unstable angina basing on studying of pathogenic mechanisms and prognostic value of silent myocardial ischemia and comparative evaluation of different regimens of therapy. It was estimated that destabilization of coronary heart disease was accompanied by decreasing of frequency, mean and total duration of silent myocardial ischemia. The role of lipid exchange and blood coagulation system disorders in development of episodes of silent myocardial ischemia was shown. The criteria of unfavourable short- term outcome in patients with unstable angina were estimated. The different regimens of antianginal therapy of patients with unstable angina and episodes of silent myocardial ischemia including beta-blocker atenolol and calcium antagonist diltiazem were worked out. The unfavourable influences of persistence of episodes of silent myocardial ischemia during antianginal treatment and lipid exchange disorders on long term outcome in 8 years were shown. Key words: unstable angina, silent myocardial ischemia, lipid exchange, the plasma link of haemostasis, atenolol, diltiazem, outcome. Nienie oiiaieo nei?i/aiue A?I - aieueiaa ?oai?y i?iea?aea AeI AEA - aeiaiaa iii?oi?oaaiiy aeaeo?iea?ae?ia?aie ?ON - ?oai?/ia oai?iaa na?oey CON - caaaeueiee oieanoa?ei EIAU - e?iii?ioa?aee aeniei? u?eueiino? EIAeIU - e?iii?ioa?aee aeoaea iecueei? u?eueiino? EIIU - e?iii?ioa?aee iecueei? u?eueiino? I?I -"i?ia" ?oai?y i?iea?aea IN - ianoaa?eueia noaiiea?ae?y IAeO - i?iaeoeoe aeaa?aaeaoe?? o?a?ei/o?a?eiiaaia NO I?I - noia?ia o?eaae?noue "i?ii?" ?oai?? i?iea?aea NO A?I - noia?ia o?eaae?noue aieueiai? ?oai?? i?iea?aea OA - o?eae?oea?eaee OA - o?a?eiiaai OE - ooieoe?iiaeueiee eean OI - o?a?iiaeoei ON- oieanoa?ei *NN - /anoioa na?oeaaeo nei?i/aiue

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