.

Нейромедіаторні та нейропептидні механізми розвитку абстинентного синдрому у морфінзалежних тварин: Автореф. дис… канд. біол. наук / М.А. Філоненко,

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Aeaaeai?y iaaee/ieo iaoe Oe?a?ie

?inoeooo oa?iaeieia?? oa oieneeieia??

O?eiiaiei Ia?eia Aiaoie??aia

OAeE 615.015.6

iae?iiaae?aoi?i? oa iae?iiaioeaei? iaoai?cie

?icaeoeo aanoeiaioiiai neiae?iio o

ii?o?icaeaaeieo oaa?ei

14.03.06 – oieneeieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a – 1998

Aeena?oaoe??th ? ?oeiien

?iaioo aeeiiaii a ?inoeooo? oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie

Iaoeia? ea??aieee:aeieoi? iaaee/ieo iaoe, i?ioani?, caneoaeaiee ae?y/
iaoee oa oaoi?ee Oe?a?ie, eao?aao i?ai?? Aeaaeai?? iaaee/ieo iaoe
Oe?a?ie A?iiia Eaii?ae Ieaenaiae?iae/, ?inoeooo oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie, caa?aeoaa/ a?aeae?eo

aeieoi? iaaee/ieo iaoe Na?aaea Iao?i ?aaiiae/, ?inoeooo oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie, aieiaiee iaoeiaee ni?a?ia?oiee

Io?oe?ei? iiiiaioe:aeieoi? a?ieia?/ieo iaoe Eieoa?ueiaa Iaoae?y
Aieiaeeie??aia, ?inoeooo aeia?a??ie oa oieneeieia?? ?i. E.?.Iaaeaaaey
IIC Oe?a?ie, ea??aiee eaai?aoi???aeieoi? iaaee/ieo iaoe Eoee Ieaenaiae?
?ai?aae/, ?inoeooo a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie,
canooiiee aee?aeoi?a c iaoeiai? ?iaioe

I?ia?aeia onoaiiaaIaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. I.I.Aiaiiieueoey, eaoaae?a ineo?ao???

Caoeno a?aeaoaeaoueny “15” aeiaoiy 1998 ?. i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.550.01 i?e ?inoeooo? oa?iaeieia??
oa oieneeieia?? AII Oe?a?ie ca aae?anith: 252057, i.Ee?a, aoe. Aaeaia
Iioue?, 14

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie ca aae?anith: 252057, i.Ee?a,
aoe. Aaeaia Iioue?, 14

Aaoi?aoa?ao ?ic?neaii “03_” aa?aniy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao a?ieia?/ieo iaoe

_____________

?.A.Aeaiiaa

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue i?iaeaie. Ia nueiaiaei? ?ic?iaea iiaeo aoaeoeaieo
cania?a oa iaoiae?a e?eoaaiiy ia?eiiai?? ? ia o?eueee iaaee/iith, aea e
aeooaeueiith nioe?aeueiith i?iaeaiith. I?i oea na?ae/aoue noaoenoe/i?
aeai?, ca?aeii yeeo a Oe?a?i? ca?a?no?iaaii aeecueei 500 oen. in?a,
caeaaeieo a?ae ia?eioee?a (E.I.A?iiia, 1996). Ca?aeii c aeaieie
Anana?oiuei? i?aai?caoe?? ioi?iie caei?ia’y, a?eueoa 50 iei /ieia?e o
anueiio na?o? aaeeaa? a iaiaaee/ieo oe?eyo ineoiaeoeai? ?a/iaeie
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991).

Na?aae an??? ??ciiiai?oiino? ?a/iaei, yeeie ceiaaeeaathoue, iae/ano?oa
cono??/athoueny eonoa?ii aeaioiaeai? ia?eioeee c iaeo oa eiiiie?
(Y.A.Aaaayi, I.O.Aiiiiieueneee, 1990; Ae.I.Aeeeaei, A.A.Aeai?ieeia,
1991), a oaeiae ia?eioe/i? e?ea?nuee? caniae a?oie ii?ao?a
(A.A.Aeoiaaaneee, A.Ae.Noyaeeei, 1990; A.A.Oaiiaaeia, 1996).

Iaaaciaea aaeeaaiiy ia?eioee?a a?oie ii?ao?a iieyaa? a oiio, ui aei
oeeo ?a/iaei aeoaea oaeaeei ?icaeaa?oueny oiea?aioi?noue, ineo?/ia oa
o?ce/ia caeaaei?noue, a i?e i?eieiaii? ?o i?eeiio – oyaeeee ca nai?ie
ee?i?/ieie oa ineo?/ieie i?iyaaie aanoeiaioiee neiae?ii (A.N.Aeoaineee
e ae?., 1989; E.N.Aieioianeee, 1989; A.A.Aeoiaaaneee, A.Ae.Noyaeeei,
1990; E.I.Iyoieoeeay, 1994).

C?icoi?eei ? oa, ui oni?o oa?iaeioa?ai?? onueiai niaeo?o i?iya?a
ia?eiiai?? ye oai?iae eaaeeoue ia aaaeaeyo ooiaeaiaioaeueieo
aeine?aeaeaiue iaoiaaiaco oeueiai iaoieia?/iiai noaio.

Ia caaaeath/e ia oa, ui ia?eiiai?? a?aeii? ethaenoao ia i?ioyc?
noie?oue (E.I.Iyoieoeeay, 1994), ?ioaineaia aea/aiiy iaoai?ci?a ?icaeoeo
ia?eiiai?e, cie?aia, ii?eieo, ii/aeinue ia ii/aoeo 70-o ?ie?a c
a?aee?eooy a aieiaiiio iiceo oaa?ei cii naiinoeioeyoe?? (cii iiceoeaiiai
i?aee??ieaiiy). A oie aea /an aoee a?aee?eo? ii?aoi? ?aoeaioi?e (N.Pert,
S.H.Snydes, 1973) oa ?o aiaeiaaii? e?aaiaee – ii?i?aei? iae?iiaioeaee:
eae-aieaoae?i, iao-aieaoae?i, aiaei?o?ie (A.A.Einoa?eeoe, Ae.Ouethn,
1981). Ciaoe?aeuei? aeine?aee iieacaee, ui aieaoae?ia?a?/i? iae?iie
o?nii iia’ycai? ?c ciiaie naiiiiae?aciaiiy (I.Eioainii e ae?., 1981;
E.Noaei, Aeae.Aaeeooee, 1981; O.-TH.ssia e ae?., 1981), a nai?
aieaoae?ie iiaeooue aieeaaoe ia ?aaeoe?th naiinoeioeyoe?? iaaieo
no?oeoo? aieiaiiai iiceo iiae?aii aei ii?o?io (TH.Ae.Eaiaoia e ae?.,
1981; TH.Ae.Eaiaoia, 1982) ? iaa?oue aeeeeeaoe ?aaeoe?th naiiaaaaeaiiy
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991; TH.Ae.Eaiaoia e ae?., 1981;
E.Noaei, Aeae.Aaeeooee, 1981).

Ia i?aenoaa? iienaieo aeua aeaieo aoea cai?iiiiiaaia a?iioaca i?i aieea
ia?eioee?a ii?eii? a?oie ia ciie iiceoeaiiai oa iaaaoeaiiai
i?aee??ieaiiy aieiaiiai iiceo (A.A.Aaeueaeiai e ae?., 1988; Y.Y.Caa?oao,
1990; A.O.Iaua?yeia, N.E.Noaeaeia, 1991; E.A.Noaeaeia, 1990), yea ia
nueiaiaei? aaaaea?oueny iaea?eueo a?aoiaioiaaiith (Y.Y.Caa?oao, 1990).

Ca?aeii oe??? a?iioace, aeciaaii? ii?aoe aieeaathoue ia aiioe?iaaii?
oeaio?e aieiaiiai iiceo ? aeeeeeathoue iiceoeai? aiioe?? (aeoi??th) ye
/a?ac ii?aoi? ?aoeaioi?e, oae ? iiina?aaeeiaaii /a?ac ci?ie o
ooeoe?iioaaii? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991; A.A.Aaeueaeiai e ae?., 1988;
E.A.Noaeaeia, 1990).

Oi?ioaaiiy oaeeo ?ioaa?aoeaieo ineoio?c?ieia?/ieo ooieoe?e ye
aiioe?iiaeueia iiaaae?iea aaaaoi a /iio aaco?oueny ia ??ciiiai?oi?e
aca?iiae?? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo, o oiio /ene?
ai?iiiaeueieo, iaoai?ci?a. O ca’yceo c aeuaaeeeaaeaiei, aeine?aeaeaiiy
o/ano? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai o ?icaeoeo
caeaaeiino? a?ae ia?eioe/ieo aiaeueaaoee?a oa aanoeiaioiiai neiae?iio ?
iaeiei c aeooaeueieo ieoaiue no/anii? ia?eieia??.

Oaeei /eiii, i?eaaaeai? aeai? na?ae/aoue i?i iaiao?aei?noue aea/aiiy
o/ano? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai o oi?ioaaii?
ia?eiiai?? c iaoith iioei?caoe?? ?nioth/eo iaoiae?a e?eoaaiiy aeacaii?
iaoieia??.

Iaoa oa iniiai? caaea/? ?iaioe. Iaoith ?iaioe aoei c’ynoaaiiy ?ie?
iae?iiaae?aoi?ieo ? iae?iiaioeaeieo nenoai o iaoai?ci? ?icaeoeo
caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai neiae?iio ye iniiae iiooeo
iioaioe?eieo e?ea?nueeeo cania?a aeey e?eoaaiiy ii?eii? ia?eiiai??.

Aeey aeinyaiaiiy iinoaaeaii? iaoe ae??ooaaeenue oae? caaea/?:

1) aeine?aeaeaiiy ai?noo iiiiai?i?a o a?iioaeaion? oa ei?? aieiaiiai
iiceo a ??ci? oa?i?ie ?icaeoeo caeaaeiino? oa aanoeiaioiiai neiae?iio
o ii?o?icaeaaeieo uo??a;

2) i?iaaaeaiiy oa?iaeieia?/iiai aiae?co ooieoe?iioaaiiy
iae?iiaae?aoi?ieo nenoai i?e ii?o?iiaiio aanoeiaioiiio neiae?ii?;

3) aea/aiiy ae?? aaii?no?a oa aaii?no?a/aioaaii?no?a ii?aoieo
?aoeaioi??a ia ia?aa?a aanoeiaioiiai neiae?iio;

4) aeine?aeaeaiiy aieeao iae?iiaioeae?a iaii?i?aeii? a?oie ia ia?aa?a
aanoeiaioiiai neiae?iio.

Iaoeiaa iiaecia ?iaioe. Aia?oa iieacaii, ui o iaoiaaiac? aanoeiaioiiai
neiae?iio aaeeea ?ieue iaeaaeeoue ii?ooaiiyi o ooieoe?iioaaii?
aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai, ye? caeeth/athoueny o
cia/iiio cieaeaii? ae?aiaciio ?o ooieoe?iiaeueieo iiaeeeainoae. Oea
iieiaeaiiy i?aeoaa?aeaeo?oueny oei, ui, ia a?aei?io a?ae ci?i o noai?
aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai i?ney iaeii?aciaiai aaaaeaiiy
ii?o?io, ??aaiue ii?aae?aiae?io ? aeioai?io a aieiaiiio iiceo i?e
aanoeiaioe?? ia ci?ith?oueny, a oa?iaeieia?/ia aeoeaaoe?y aae?aia?a?/ii?
oa aeioai?ia?a?/ii? nenoai ciaioo? i?iyae aanoeiaioiiai neiae?iio, oiae?
ye i?eai?/aiiy ooieoe?iioaaiiy oeeo nenoai oeyoii aaaaeaiiy aioaaii?no?a
aae?aia?a?/ieo ? aeioai?ia?a?/ieo ?aoeaioi??a iineeth? i?iyae neiae?iio
a?aeiyooy.

Anoaiiaeaii, ui aanoeiaioiee neiae?ii ?icaeaa?oueny ia oii? cieaeaii?
aeoeaiino? na?ioii?i- ? AAIE-a?a?/ii? nenoai. Oae, ?icaeoie caeaaeiino?
noi?iaiaeaeo?oueny iinooiiaei ciaioaiiyi ai?noo na?ioii?io ? o?eioioaio,
a nenoaiia aaaaeaiiy L-o?eioioaio cieaeo? ?iaeaen aanoeiaioe?? o
ii?o?icaeaaeieo uo??a.

Iieacaii, ui aeoeaaoi?e AAIE-a?a?/ii? nenoaie ionoeeiie ? aaeeioai
ciaioothoue, a ?ia?a?oi?e ooieoe?iioaaiiy oe??? nenoaie o?inaieea?aaceae
? a?eoeoe?i ca?eueoothoue ?iaeaen aanoeiaioe??.

Anoaiiaeaii, ui o iaoiaaiac? aanoeiaioiiai neiae?iio aaaeeeaa cia/aiiy
ia? ii?ooaiiy ooieoe?iiaeueii? aca?iiae?? ??cieo iiioeyoe?e ii?aoieo
?aoeaioi??a, a naia ith-, aeaeueoa- oa eaiia- oei?a. Aenia?eiaioaeueii
aeiaaaeaia o/anoue a iaoai?ci? oi?ioaaiiy oeueiai neiae?iio iaii?i?aeieo
iae?iiaioeae?a ieneoioeeio ? aacii?aneio.

Iaoeiai-i?aeoe/ia cia/aiiy ?iaioe. Io?eiai? ?acoeueoaoe aeine?aeaeaiiy
iaoiaaiaco aanoeiaioiiai neiae?iio iieacothoue, ui a ?icaeoeo oeueiai
iaoieia?/iiai noaio i?eeiathoue o/anoue ??ci? eaiee iae?io?i?/ii?
?aaoeyoe?? aiioe?eiiai noaio.

O ca’yceo c oeei iaa?yae /e iiaeia i/?eoaaoe iiaiiai onoiaiiy
aanoeiaioiiai neiae?iio o oai?eo ia ii?eio ia?eiiai?th oeyoii
aeei?enoaiiy iiiioa?aiaaoe/iiai e?eoaaiiy. Iaea?eueo ?aoe?iiaeueiith oa
aoaeoeaiith oa?ai??th ? aeei?enoaiiy i?aia?ao?a, ui aeoeaothoue
aae?aii-, aeioai?ii-, na?ioii?ii- oa AAIE-a?a?/io nenoaie. Ca?aeii
io?eiaieo aenia?eiaioaeueieo aeaieo, c iaoith i?io?eaeoeee ?icaeoeo
aanoeiaioiiai neiae?iio o oai?eo ia ia?eiiai?th oa e?eoaaiiy oeueiai
iaoieia?/iiai noaio iiaea aooe ?aeiiaiaeiaaii canoinoaaiiy eaaiaeiie,
aoaae?eio, oai?eao?eio ? o?eioioaio. ?c aeoeaaoi??a AAIE-a?a?/ii?
nenoaie iaea?eueo aoaeoeaiei ? aaeeioai. Aeineoue ia?niaeoeaiei iiaea
aooe aeei?enoaiiy aaii?noa ii?aoieo ?aoeaioi??a eiia?ai?aeo.

E??i oiai, oae? iaii?i?aei? iae?iiaioeaee ye ieneoioeei ? aacii?anei
oaeiae iiaeooue aooe ?aeiiaiaeiaai? aeey ee?i?/ii? ai?iaaoe?? i?e
e?eoaaii? aanoeiaioiiai neiae?iio.

Aeaniee aianie aaoi?a caeeth/a?oueny a naiino?eiiio i?iaaaeaii? an?o
aenia?eiaioaeueieo aeine?aeaeaiue, aiae?c? e?oa?aoo?ieo aeaieo,
noaoenoe/i?e ia?iaoe? oa aiae?c? aeanieo ?acoeueoao?a, ?ic?iaoe?
iniiaieo iieiaeaiue oa aeniiae?a ?iaioe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eio
?iaioo aeeiiaii o ?one? iaoeiai-aeine?aeii? oaiaoeee a?aeae?eo
iae?ioa?iaeieia?? ?inoeoooo oa?iaeieia??? oa oieneeieia?? AII Oe?a?ie,
oaie AeEIO ? 72 (oeo? 01.12.03/003-94 iae?iiaioeaee) “Aeine?aeaeaiiy
iae?iiaioeaeieo oa a?eueii?aaeeeaeueieo iaoiaaiaoe/ieo iaoai?ci?a
?icaeoeo ia?eiiai??” (1994-1995 ??., ? aea?ae?a?no?aoe?? 0195U011279),
oaie AII Oe?a?ie ? 4 (oeo? AII.10.0004.95) “Iae?iiaioeaei? oa
a?eueii?aaeeeaeuei? iaoai?cie aanoeiaioiiai neiae?iio i?e ii?ei?e
ia?eiiai?? ? ?ic?iaea iaoiae?a e?eoaaiiy aeaiiai iaoieia?/iiai noaio”
(1995-1997 ??., ? aea?ae?a?no?aoe?? 0195U010053), oaie AII Oe?a?ie ? 6
“Ania?eiaioaeueia iaa?oiooaaiiy eoie?oaaiiy aanoeiaioiiai neiae?iio i?e
ii?o?iia?e ia?eiiai?? oeyoii aieeao ia ii?aoi? ?aoeaioi?e” (1996-1998
??., ? aea?ae?a?no?aoe?? 0196U003295).

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? iioae?eiaaii o 10 ae?oeiaaieo
?iaioao (5 noaooyo oa 5 oacao aeiiia?aeae), o oiio /ene? 7 naiino?eieo.
?acoeueoaoe aeine?aeaeaiue aeiiia?aeaeenue ia can?aeaiiyo Ia?oiai
iaoe?iiaeueiiai c’?caeo oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie
oa?iaeieia??” (Iieoaaa, 1995), Ia?oi? Ana?in?enueei? eiioa?aioe??
oieneeieia?a “Aeooaeueiua i?iaeaiu oai?aoe/aneie e i?eeeaaeiie
oieneeieiaee” (Naieo-Iaoa?ao?a, 1995), 1-ai I?aeia?iaeiiai iaaee/iiai
Eiia?ano nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1997), Ia?oiai
iaoe?iiaeueiiai eiia?ano iaa?ieia?a, ineo?ao??a oa ia?eieia?a Oe?a?ie
(Oa?e?a, 1997), 2-ai I?aeia?iaeiiai iaaee/iiai Eiia?ano nooaeaio?a ?
iieiaeeo a/aieo (Oa?iii?eue, 1998).

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe. ??oaiiyi Oa?iaeieia?/iiai eii?oaoo
IIC Oe?a?ie (i?ioieie ? 10 a?ae 25.12.97) aeicaieaii i?iaaaeaiiy
ee?i?/ieo aei?iaoaaiue i?aia?aoo aaeeioai ca iiaei i?ecia/aiiyi aeey
e?eoaaiiy aanoeiaioiiai neiae?iio o oai?eo ia ii?eio ia?eiiai?th.

No?oeoo?a oa ia’?i aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, ?icae?eo “Iaoa??aee oa iaoiaee aeine?aeaeaiue”,
aeanieo aenia?eiaioaeueieo aeine?aeaeaiue, iaaiai?aiiy io?eiaieo
?acoeueoao?a, caeeth/aiiy oa aeniiae?a. Ia’?i ?iaioe noaiiaeoue 191
noi??ieo iaoeiiieniiai oaenoo, ui aeeth/a? 17 ?enoie?a oa 30 oaaeeoeue.
Iieaciee e?oa?aoo?e ia? 247 iaeiaioaaiue, c yeeo 128 a?o/eciyieo oa 119
?iicaiieo aeaea?ae.

Iieiaeaiiy, ui aeiinyoueny ia caoeno.

1. Aanoeiaioiee neiae?ii i?e ii?o?iia?e caeaaeiino? iaoiiaeaiee
ii?ooaiiyie o ooieoe?iioaaii? iae?iiaae?aoi?ieo ? iae?iiaioeaeieo
nenoai, ui ?aaoeththoue aiioe?eio iiaaae?ieo.

2. Aanoeiaioiee neiae?ii ?icaeaa?oueny ia oii? iaiaaeaiiy ae?aiaciio
ooieoe?iiaeueieo iiaeeeainoae aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai.

3. I?e aanoeiaioiiio neiae?ii? a?aei?/a?oueny ??cea cieaeaiiy aeoeaiino?
na?ioii?ia?a?/ii? oa AAIE-a?a?/ii? nenoai.

4. I?e oi?ioaaii? aanoeiaioiiai neiae?iio a?aeaoaathoueny ci?ie o
aca?iiae?? ith-, aeaeueoa- oa eaiia-ii?aoieo ?aoeaioi??a.

5. O iaoiaaiac? aanoeiaioiiai neiae?iio iaaia ?ieue iaeaaeeoue
aacii?anei- oa ieneoioeeia?a?/iei iaii?i?aeiei iae?iiaioeaeiei nenoaiai.

6. Aeey onoiaiiy aanoeiaioiiai neiae?iio i?e ii?ei?e ia?eiiai?? ne?ae
i?iaiaeeoe eiiieaenio oa?iaeioa?ai?th c aeei?enoaiiyi oai?eao?eio*
(iacaoiio), aoaae?eio*, eaaiaeiie* (L-3,4-ae?ieneoai?eaeai?io),
L-o?eioioaio, aaeeioaio*, ieneoioeeio oa aacii?aneio.

Iniiaiee ci?no ?iaioe

iaoa??ae oa iaoiaee aeine?aeaeaiue

Aeine?aee i?iaaaeai? ia 713 noaoaaic??eeo iae?i?eieo a?eeo uo?ao-naioeyo
ianith 170-230 a ?icaaaeaiiy ?inoeoooo oa?iaeieia?? oa oieneeieia?? AII
Oe?a?ie. Oaa?ei oo?eioaaee ia noaiaea?oiiio aiaeii-oa?/iaiio ?aoe?ii?
i?e a?eueiiio aeinooi? aei aiaee oa ?ae?. C iaoith i?iaaaeaiiy
a?io?i?/ieo aeine?aeaeaiue uo??a aeaeai?ooaaee, ?ioeo oaa?ei aeaiaeeee c
aeine?aeo oeyoii iii?uaiiy ?o a eaia?o c aoiinoa?ith, iane/aiith ia?aie
iaaee/iiai ao??o.

O?ce/io caeaaei?noue a?ae ii?o?io a?ae?ioei?eaeo aeeeeeaee oeyoii
uiaeaiieo aeai?aciaeo (i 10.00 oa 18.00) ?io?aia?eoiiaaeueieo (?/i)
?i’?eoe?e ia?eioeea a c?inoath/eo aeicao (ia 5 ia/ea iane o?ea
uiaeiaiai) a?ae 5 aei 65 ia/ea (N.E.Noaeaeia e ae?., 1994).
Aenia?eiaioaeueiee aanoeiaioiee neiae?ii aeeeeeaee aaaaeaiiyi
ii?o?icaeaaeiei oaa?eiai aioaaii?noa ii?aoieo ?aoeaioi??a iaeieniio (?/i
a aeic? 1 iaea ca 30 oa aei niinoa?aaeaiiy) aai i?eieiaiiyi aaaaeaiiy
ii?o?io (aeine?ae ii/eiaee /a?ac 16 aiae i?ney inoaiiuei? ?i’?eoe??).
Oyaee?noue aanoeiaioe?? ioe?ithaaee ca 11 ee?i?/ieie i?iyaaie neiae?iio
oeyoii a?coaeueiiai niinoa?aaeaiiy ia i?ioyc? 3 oa ? ae?aaeaee
?iaeaenii aanoeiaioe?? a aaeao.

Ai?no ii?aae?aiae?io, aeioai?io, na?ioii?io oa o?eioioaio a a?iioaeaion?
oa ei?? aaeeeeo i?aeoeue aieiaiiai iiceo uo??a aecia/aee iaoiaeii
aenieiaoaeoeaii? ??aeeiii? o?iiaoia?ao?? c aeei?enoaiiyi HPLC “System
346” (eieiiea “Ultrasphere ODS” 4,6 o 250, aeaoaeoi?-oethi?eiao? c
aeiaaeeiith oaee? caoaeaeaiiy 200 ii) (W.A.Hunt, O.E.Dalton, 1983).
Oaa?ei aeaeai?ooaaee /a?ac 30 oa i?ney aaaaeaiiy a?aeiia?aeii? ?a/iaeie
(?ic/eiieea – aiaee aeey ?i’?eoe?e, ii?o?io aai iaeieniio).

sse noaiaea?oe aeei?enoiaoaaee ?ic/eie ii?aae?aiae?io, aeioai?io,
na?ioii?io (“Sigma”), DL-o?eioioaio (“Reanal”) a eiioeaio?aoe?? 1-5
ia/100 ie 0,1 I oei?ii? eeneioe, ye? ia?aae aeine?aeaeaiiyi ?icaiaeeee
aei iaiao?aeii? eiioeaio?aoe?? (1:1000).

Oa?iaeieia?/iee aiae?c iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai
i?iaiaeeee c ____________

* – iaaaaeaia i?aeia?iaeia iaiaoaioiaaia iacaa

aeei?enoaiiyi i?aia?ao?a oa ?a/iaei, ui naeaeoeaii ae?thoue ia ??ci?
eaiee neiaioe/ii? ia?aaea/?, cie?aia aae?aii-, aeioai?ii-, na?ioii?ii-,
AAIE-, oie?ii- oa ii?aoii? nenoai (oaae. 1). Ioe?ithaaee aieea
iiia?aaeiueiai aaaaeaiiy oa?iaeieia?/ieo aiae?caoi??a ye ia cia/aiiy
?iaeaena aanoeiaioe?? a oe?eiio, oae ? iniaeeaino? ee?i?/ii? ea?oeie
neiae?iio a?aeiyooy. An? ?a/iaeie, e??i aooi?oaiieo, aaiaeeee ?/i.

Io?eiai? ?acoeueoaoe ia?iaeyee ca aeiiiiiaith i?ia?aiiiai i?iaeoeoo
“Statgraf”, ioe?ieo a??ia?aeiino? a?aei?iiinoae i?iaiaeeee c
aeei?enoaiiyi t – e?eoa??y No’thaeaioa oa – eiao?oe??ioa ?aiaiai?
ei?aeyoe?? Ni??iaia (I.I.Ieioea? e ae?., 1991).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

Iiiiai?ia?a?/ia nenoaia. ?acoeueoaoe aeine?ae?a aeicaieeee c?iaeoe
aeniiaie, ui ?icaeoie caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai
neiae?iio noi?iaiaeaeothoueny cieaeaiiyi ae?aiaciio ooieoe?iiaeueieo
iiaeeeainoae ?aaaoaaiiy aae?aia?a?/ii? nenoaie. I?i oea na?ae/eoue
a?aenooi?noue ci?i i?ney o?eaaeiai canoinoaaiiy ii?o?io a a?iioaeaion?
oa ei?? (oaae. 2, 3), oiae? ye iaeii?aciaa aaaaeaiiy ii?o?io aeeeeea?
i?aeaeuaiiy ??aiy ii?aae?aiae?io a ei?? (oaae. 3).

Aaaaeaiiy ia oeueiio oii? noeioeyoi??a aae?aia?a?/ii? nenoaie aoaae?eio
a aeic? 2 ia/ea (niiioaiia aanoeiaioe?y) aai aaii?noa
1-aae?aii?aoeaioi??a oai?eao?eio (iacaoiio) a aeic? 1 ia/ea ca 1 aiae
aei niinoa?aaeaiiy (iaeieniiiaa aanoeiaioe?y) cieaeoaaei ae?aaeai?noue
ee?i?/ieo i?iya?a aanoeiaioiiai neiae?iio. ?iaeaen aanoeiaioe?? i?e
oeueiio aeinoia??ii cieaeoaaany ia 74,5% oa 38,6% a?aeiia?aeii. Ii?yae c
oeei aaaaeaiiy aioaaii?noa 1-aae?aii?aoeaioi??a i?aciceio a aeic? 0,5
ia/ea ca 1 aiae aei niinoa?aaeaiiy (niiioaiia aanoeiaioe?y) iia??ooaaei
ia?aa?a aanoeiaioiiai neiae?iio – ?iaeaen aanoeiaioe?? ca?eueooaaany ia
77,8%. Aaaaeaiiy ii?o?icaeaaeiei oaa?eiai aaii?noa 2-aae?aii?aoeaioi??a
eeii?aeeio a aeic? 0,1 ia/ea ca 1 aiae aei niinoa?aaeaiiy (iaeieniiiaa
aanoeiaioe?y) ia aieeaaei ia oyaee?noue aanoeiaioiiai neiae?iio.

Oe? ?acoeueoaoe i?aeoaa?aeaeothoue aeniiaie uiaei ?icaeoeo aanoeiaioe??
ia oii? iaiaaeaiiy ooieoe?iiaeueieo iiaeeeainoae aae?aia?a?/ii? nenoaie.
I?e oeueiio a?eueo aaaeeeaa cia/aiiy ia? 1-aae?aia?a?/ia eaiea
aeine?aeaeoaaii? iae?iiaae?aoi?ii? nenoaie.

I?e oi?ioaaii? caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai neiae?iio
niinoa??aaee oaeiae cieaeaiiy ae?aiaciio ooieoe?iiaeueieo iiaeeeainoae
?aaaoaaiiy aeioai?ia?a?/ii? nenoaie ia aaaaeaiiy ia?eioeea. I?i oea
na?ae/aoue aeai? uiaei ai?noo aeioai?io a a?iioaeaion? aieiaiiai iiceo
oaa?ei (oaae. 2). Oae, iaeii?aciaa aaaaeaiiy ii?o?io ia ci?ithaaei ??aiy
oeueiai iae?iiaae?aoi?a. Ia 5 aeiao aaaaeaiiy ia?eioeea ai?no aeioai?ia
a a?iioaeaion? ciaiooaaany, iaeiae caeeoaany aac ci?i a ?io? oa?i?ie
oi?ioaaiiy caeaaeiino?, a oaeiae i?e ?icaeoeo aanoeiaioiiai neiae?iio.

Oaaeeoey 1

Ia?ae?e aeei?enoaieo a ?iaio? oa?iaeieia?/ieo aiae?caoi??a

??

i/iNenoaiaIacaa ?a/iaeieOa?iaeieia?/ia ae?yAeei?enoaia aeica,
ia/ea1.Aae?aia?a?/iaAoaae?eiIai?yiee aae?aiii?iaoee2,02.- “
-I?aciceiAeieaoi? 1-aae?aii?aoeaioi??a 0,53.- “ -Oai?eao?eiAaii?no
1-aae?aii?aoeaioi??a1,04.- “ -Eeii?aeeiAaii?no
2-aae?aii?aoeaioi??a0,15.Aeioai?ia?a?/iaEaaiaeiiaI?aeo?ni?
aeioai?io2006.- “ -Aiiii?o?iAaii?no ?aoeaioi??a1,07.- “
-Aaeiia?eaeieAeieaoi?
?aoeaioi??a1,08.Na?ioii?ia?a?/iaL-o?eioioaiI?aeo?ni? na?ioii?io809.- “
-Iaoeca?a?aeAeieaoi? ?aoeaioi??a0,510.AAIEa?a?/iaIonoeeiieAaii?no
AAIEA-?aoeaioi??a1,011.- “ -AaeeioaiAaii?no AAIEA-?aoeaioi??a2,012.- “
-A?eoeoe?iAeieaoi? AAIEA-?aoeaioi??a1,013.- “ -O?inaieea?aaceaeAeieaoi?
neioaca AAIE3,014.Oie?ia?a?/iaAaeaioai?iOeaio?aeueiee iai?yiee
oie?iii?iaoee

(aeieaoi? oeaio?aeueii? aoeaoeeoie?ianoa?ace)2,015.- “
-Iaoai?ceeAeieaoi? oeaio?aeueieo
I-oie?ii?aoeaioi??a5,016.Ii?aoiaIi?o?iAaii?no ith- oa eaiia-ii?aoieo
?aoeaioi??a9,017.- “ -Aooi?oaiie Aaii?no eaiia-ii?aoieo ?aoeaioi??a oa
ci?oaiee aaii?no-aioaaii?no ith-ii?aoieo ?aoeaioi??a27,018.- “
-O?aiaaeieAaii?no ith-ii?aoieo ?aoeaioi??a14,019.- “ -Eiia?ai?aeAaii?no
ia?eoa??eieo ith-ii?aoieo ?aoeaioi??a15,0

Oaaeeoey 2

Ai?no iiiiai?i?a o a?iioaeaion? aieiaiiai iiceo uo??a i?e ?icaeoeo
caeaaeiino? a?ae ii?o?io oa aanoeiaioe??

(iea/a ne?i? oeaieie)

Oiiae aeine?aeo

Ii?aae?aiae?i

Aeioai?i

Na?ioii?i

O?eioioaieiio?ieueaeine?aeeiio?ieue aeine?aeeiio?ieueaeine?aeeiio?ieue

aeine?aeIi?o?i iaeii?aciai

(9 ia/ea)1,06 0,08

n = 8

1,02 0,07

n = 82,32 0,15

n = 82,63 0,08

n = 81,92 0,15

n = 81,73 0,12

n = 83,17 0,20

n = 83,55 0,20

n = 8Caeaaei?noue, 5-a aeiaa (ii?o?i a aeic? 25 ia/ea)1,18 0,10

n = 8

1,04 0,06

n = 82,73 0,10

n = 82,36 0,14*

n = 82,20 0,12

n = 81,95 0,21

n = 82,60 0,20

n = 82,90 0,29

n = 6Caeaaei?noue, 9-a aeiaa (ii?o?i a aeic? 45 ia/ea)1,00 0,03

n = 8

0,91 0,06

n = 82,06 0,15

n = 81,90 0,12

n = 81,59 0,08

n = 81,25 0,12*

n = 82,09 0,21

n = 82,07 0,15

n = 8Caeaaei?noue, 13-a aeiaa (ii?o?i a aeic? 65 ia/ea)1,45 0,10

n = 81,55 0,13

n = 81,69 0,25

n = 81,81 0,19

n = 83,23 0,49

n = 81,39 0,17*

n = 83,06 0,33

n = 63,34 0,27

n = 7Aanoeiaioe?y

(iaeienii a aeic? 1 ia/ea)1,55 0,13

n = 81,62 0,12

n = 81,81 0,19

n = 82,29 0,15

n = 81,39 0,17

n = 81,63 0,23

n = 83,34 0,27

n = 72,09 0,16*

n = 7

I?ei?oee :

1. – * ?

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