Aeaaeai?y iaaee/ieo iaoe Oe?a?ie

?inoeooo oa?iaeieia?? oa oieneeieia??

O?eiiaiei Ia?eia Aiaoie??aia

OAeE 615.015.6

iae?iiaae?aoi?i? oa iae?iiaioeaei? iaoai?cie

?icaeoeo aanoeiaioiiai neiae?iio o

ii?o?icaeaaeieo oaa?ei

14.03.06 — oieneeieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioo aeeiiaii a ?inoeooo? oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie

Iaoeia? ea??aieee:aeieoi? iaaee/ieo iaoe, i?ioani?, caneoaeaiee ae?y/
iaoee oa oaoi?ee Oe?a?ie, eao?aao i?ai?? Aeaaeai?? iaaee/ieo iaoe
Oe?a?ie A?iiia Eaii?ae Ieaenaiae?iae/, ?inoeooo oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie, caa?aeoaa/ a?aeae?eo

aeieoi? iaaee/ieo iaoe Na?aaea Iao?i ?aaiiae/, ?inoeooo oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie, aieiaiee iaoeiaee ni?a?ia?oiee

Io?oe?ei? iiiiaioe:aeieoi? a?ieia?/ieo iaoe Eieoa?ueiaa Iaoae?y
Aieiaeeie??aia, ?inoeooo aeia?a??ie oa oieneeieia?? ?i. E.?.Iaaeaaaey
IIC Oe?a?ie, ea??aiee eaai?aoi???aeieoi? iaaee/ieo iaoe Eoee Ieaenaiae?
?ai?aae/, ?inoeooo a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie,
canooiiee aee?aeoi?a c iaoeiai? ?iaioe

I?ia?aeia onoaiiaaIaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. I.I.Aiaiiieueoey, eaoaae?a ineo?ao???

Caoeno a?aeaoaeaoueny “15” aeiaoiy 1998 ?. i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.550.01 i?e ?inoeooo? oa?iaeieia??
oa oieneeieia?? AII Oe?a?ie ca aae?anith: 252057, i.Ee?a, aoe. Aaeaia
Iioue?, 14

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie ca aae?anith: 252057, i.Ee?a,
aoe. Aaeaia Iioue?, 14

Aaoi?aoa?ao ?ic?neaii “03_” aa?aniy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao a?ieia?/ieo iaoe

_____________

?.A.Aeaiiaa

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue i?iaeaie. Ia nueiaiaei? ?ic?iaea iiaeo aoaeoeaieo
cania?a oa iaoiae?a e?eoaaiiy ia?eiiai?? ? ia o?eueee iaaee/iith, aea e
aeooaeueiith nioe?aeueiith i?iaeaiith. I?i oea na?ae/aoue noaoenoe/i?
aeai?, ca?aeii yeeo a Oe?a?i? ca?a?no?iaaii aeecueei 500 oen. in?a,
caeaaeieo a?ae ia?eioee?a (E.I.A?iiia, 1996). Ca?aeii c aeaieie
Anana?oiuei? i?aai?caoe?? ioi?iie caei?ia’y, a?eueoa 50 iei /ieia?e o
anueiio na?o? aaeeaa? a iaiaaee/ieo oe?eyo ineoiaeoeai? ?a/iaeie
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991).

Na?aae an??? ??ciiiai?oiino? ?a/iaei, yeeie ceiaaeeaathoue, iae/ano?oa
cono??/athoueny eonoa?ii aeaioiaeai? ia?eioeee c iaeo oa eiiiie?
(Y.A.Aaaayi, I.O.Aiiiiieueneee, 1990; Ae.I.Aeeeaei, A.A.Aeai?ieeia,
1991), a oaeiae ia?eioe/i? e?ea?nuee? caniae a?oie ii?ao?a
(A.A.Aeoiaaaneee, A.Ae.Noyaeeei, 1990; A.A.Oaiiaaeia, 1996).

Iaaaciaea aaeeaaiiy ia?eioee?a a?oie ii?ao?a iieyaa? a oiio, ui aei
oeeo ?a/iaei aeoaea oaeaeei ?icaeaa?oueny oiea?aioi?noue, ineo?/ia oa
o?ce/ia caeaaei?noue, a i?e i?eieiaii? ?o i?eeiio — oyaeeee ca nai?ie
ee?i?/ieie oa ineo?/ieie i?iyaaie aanoeiaioiee neiae?ii (A.N.Aeoaineee
e ae?., 1989; E.N.Aieioianeee, 1989; A.A.Aeoiaaaneee, A.Ae.Noyaeeei,
1990; E.I.Iyoieoeeay, 1994).

C?icoi?eei ? oa, ui oni?o oa?iaeioa?ai?? onueiai niaeo?o i?iya?a
ia?eiiai?? ye oai?iae eaaeeoue ia aaaeaeyo ooiaeaiaioaeueieo
aeine?aeaeaiue iaoiaaiaco oeueiai iaoieia?/iiai noaio.

Ia caaaeath/e ia oa, ui ia?eiiai?? a?aeii? ethaenoao ia i?ioyc?
noie?oue (E.I.Iyoieoeeay, 1994), ?ioaineaia aea/aiiy iaoai?ci?a ?icaeoeo
ia?eiiai?e, cie?aia, ii?eieo, ii/aeinue ia ii/aoeo 70-o ?ie?a c
a?aee?eooy a aieiaiiio iiceo oaa?ei cii naiinoeioeyoe?? (cii iiceoeaiiai
i?aee??ieaiiy). A oie aea /an aoee a?aee?eo? ii?aoi? ?aoeaioi?e (N.Pert,
S.H.Snydes, 1973) oa ?o aiaeiaaii? e?aaiaee — ii?i?aei? iae?iiaioeaee:
eae-aieaoae?i, iao-aieaoae?i, aiaei?o?ie (A.A.Einoa?eeoe, Ae.Ouethn,
1981). Ciaoe?aeuei? aeine?aee iieacaee, ui aieaoae?ia?a?/i? iae?iie
o?nii iia’ycai? ?c ciiaie naiiiiae?aciaiiy (I.Eioainii e ae?., 1981;
E.Noaei, Aeae.Aaeeooee, 1981; O.-TH.ssia e ae?., 1981), a nai?
aieaoae?ie iiaeooue aieeaaoe ia ?aaeoe?th naiinoeioeyoe?? iaaieo
no?oeoo? aieiaiiai iiceo iiae?aii aei ii?o?io (TH.Ae.Eaiaoia e ae?.,
1981; TH.Ae.Eaiaoia, 1982) ? iaa?oue aeeeeeaoe ?aaeoe?th naiiaaaaeaiiy
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991; TH.Ae.Eaiaoia e ae?., 1981;
E.Noaei, Aeae.Aaeeooee, 1981).

Ia i?aenoaa? iienaieo aeua aeaieo aoea cai?iiiiiaaia a?iioaca i?i aieea
ia?eioee?a ii?eii? a?oie ia ciie iiceoeaiiai oa iaaaoeaiiai
i?aee??ieaiiy aieiaiiai iiceo (A.A.Aaeueaeiai e ae?., 1988; Y.Y.Caa?oao,
1990; A.O.Iaua?yeia, N.E.Noaeaeia, 1991; E.A.Noaeaeia, 1990), yea ia
nueiaiaei? aaaaea?oueny iaea?eueo a?aoiaioiaaiith (Y.Y.Caa?oao, 1990).

Ca?aeii oe??? a?iioace, aeciaaii? ii?aoe aieeaathoue ia aiioe?iaaii?
oeaio?e aieiaiiai iiceo ? aeeeeeathoue iiceoeai? aiioe?? (aeoi??th) ye
/a?ac ii?aoi? ?aoeaioi?e, oae ? iiina?aaeeiaaii /a?ac ci?ie o
ooeoe?iioaaii? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai
(Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991; A.A.Aaeueaeiai e ae?., 1988;
E.A.Noaeaeia, 1990).

Oi?ioaaiiy oaeeo ?ioaa?aoeaieo ineoio?c?ieia?/ieo ooieoe?e ye
aiioe?iiaeueia iiaaae?iea aaaaoi a /iio aaco?oueny ia ??ciiiai?oi?e
aca?iiae?? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo, o oiio /ene?
ai?iiiaeueieo, iaoai?ci?a. O ca’yceo c aeuaaeeeaaeaiei, aeine?aeaeaiiy
o/ano? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai o ?icaeoeo
caeaaeiino? a?ae ia?eioe/ieo aiaeueaaoee?a oa aanoeiaioiiai neiae?iio ?
iaeiei c aeooaeueieo ieoaiue no/anii? ia?eieia??.

Oaeei /eiii, i?eaaaeai? aeai? na?ae/aoue i?i iaiao?aei?noue aea/aiiy
o/ano? iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai o oi?ioaaii?
ia?eiiai?? c iaoith iioei?caoe?? ?nioth/eo iaoiae?a e?eoaaiiy aeacaii?
iaoieia??.

Iaoa oa iniiai? caaea/? ?iaioe. Iaoith ?iaioe aoei c’ynoaaiiy ?ie?
iae?iiaae?aoi?ieo ? iae?iiaioeaeieo nenoai o iaoai?ci? ?icaeoeo
caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai neiae?iio ye iniiae iiooeo
iioaioe?eieo e?ea?nueeeo cania?a aeey e?eoaaiiy ii?eii? ia?eiiai??.

Aeey aeinyaiaiiy iinoaaeaii? iaoe ae??ooaaeenue oae? caaea/?:

1) aeine?aeaeaiiy ai?noo iiiiai?i?a o a?iioaeaion? oa ei?? aieiaiiai
iiceo a ??ci? oa?i?ie ?icaeoeo caeaaeiino? oa aanoeiaioiiai neiae?iio
o ii?o?icaeaaeieo uo??a;

2) i?iaaaeaiiy oa?iaeieia?/iiai aiae?co ooieoe?iioaaiiy
iae?iiaae?aoi?ieo nenoai i?e ii?o?iiaiio aanoeiaioiiio neiae?ii?;

3) aea/aiiy ae?? aaii?no?a oa aaii?no?a/aioaaii?no?a ii?aoieo
?aoeaioi??a ia ia?aa?a aanoeiaioiiai neiae?iio;

4) aeine?aeaeaiiy aieeao iae?iiaioeae?a iaii?i?aeii? a?oie ia ia?aa?a
aanoeiaioiiai neiae?iio.

Iaoeiaa iiaecia ?iaioe. Aia?oa iieacaii, ui o iaoiaaiac? aanoeiaioiiai
neiae?iio aaeeea ?ieue iaeaaeeoue ii?ooaiiyi o ooieoe?iioaaii?
aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai, ye? caeeth/athoueny o
cia/iiio cieaeaii? ae?aiaciio ?o ooieoe?iiaeueieo iiaeeeainoae. Oea
iieiaeaiiy i?aeoaa?aeaeo?oueny oei, ui, ia a?aei?io a?ae ci?i o noai?
aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai i?ney iaeii?aciaiai aaaaeaiiy
ii?o?io, ??aaiue ii?aae?aiae?io ? aeioai?io a aieiaiiio iiceo i?e
aanoeiaioe?? ia ci?ith?oueny, a oa?iaeieia?/ia aeoeaaoe?y aae?aia?a?/ii?
oa aeioai?ia?a?/ii? nenoai ciaioo? i?iyae aanoeiaioiiai neiae?iio, oiae?
ye i?eai?/aiiy ooieoe?iioaaiiy oeeo nenoai oeyoii aaaaeaiiy aioaaii?no?a
aae?aia?a?/ieo ? aeioai?ia?a?/ieo ?aoeaioi??a iineeth? i?iyae neiae?iio
a?aeiyooy.

Anoaiiaeaii, ui aanoeiaioiee neiae?ii ?icaeaa?oueny ia oii? cieaeaii?
aeoeaiino? na?ioii?i- ? AAIE-a?a?/ii? nenoai. Oae, ?icaeoie caeaaeiino?
noi?iaiaeaeo?oueny iinooiiaei ciaioaiiyi ai?noo na?ioii?io ? o?eioioaio,
a nenoaiia aaaaeaiiy L-o?eioioaio cieaeo? ?iaeaen aanoeiaioe?? o
ii?o?icaeaaeieo uo??a.

Iieacaii, ui aeoeaaoi?e AAIE-a?a?/ii? nenoaie ionoeeiie ? aaeeioai
ciaioothoue, a ?ia?a?oi?e ooieoe?iioaaiiy oe??? nenoaie o?inaieea?aaceae
? a?eoeoe?i ca?eueoothoue ?iaeaen aanoeiaioe??.

Anoaiiaeaii, ui o iaoiaaiac? aanoeiaioiiai neiae?iio aaaeeeaa cia/aiiy
ia? ii?ooaiiy ooieoe?iiaeueii? aca?iiae?? ??cieo iiioeyoe?e ii?aoieo
?aoeaioi??a, a naia ith-, aeaeueoa- oa eaiia- oei?a. Aenia?eiaioaeueii
aeiaaaeaia o/anoue a iaoai?ci? oi?ioaaiiy oeueiai neiae?iio iaii?i?aeieo
iae?iiaioeae?a ieneoioeeio ? aacii?aneio.

Iaoeiai-i?aeoe/ia cia/aiiy ?iaioe. Io?eiai? ?acoeueoaoe aeine?aeaeaiiy
iaoiaaiaco aanoeiaioiiai neiae?iio iieacothoue, ui a ?icaeoeo oeueiai
iaoieia?/iiai noaio i?eeiathoue o/anoue ??ci? eaiee iae?io?i?/ii?
?aaoeyoe?? aiioe?eiiai noaio.

O ca’yceo c oeei iaa?yae /e iiaeia i/?eoaaoe iiaiiai onoiaiiy
aanoeiaioiiai neiae?iio o oai?eo ia ii?eio ia?eiiai?th oeyoii
aeei?enoaiiy iiiioa?aiaaoe/iiai e?eoaaiiy. Iaea?eueo ?aoe?iiaeueiith oa
aoaeoeaiith oa?ai??th ? aeei?enoaiiy i?aia?ao?a, ui aeoeaothoue
aae?aii-, aeioai?ii-, na?ioii?ii- oa AAIE-a?a?/io nenoaie. Ca?aeii
io?eiaieo aenia?eiaioaeueieo aeaieo, c iaoith i?io?eaeoeee ?icaeoeo
aanoeiaioiiai neiae?iio o oai?eo ia ia?eiiai?th oa e?eoaaiiy oeueiai
iaoieia?/iiai noaio iiaea aooe ?aeiiaiaeiaaii canoinoaaiiy eaaiaeiie,
aoaae?eio, oai?eao?eio ? o?eioioaio. ?c aeoeaaoi??a AAIE-a?a?/ii?
nenoaie iaea?eueo aoaeoeaiei ? aaeeioai. Aeineoue ia?niaeoeaiei iiaea
aooe aeei?enoaiiy aaii?noa ii?aoieo ?aoeaioi??a eiia?ai?aeo.

E??i oiai, oae? iaii?i?aei? iae?iiaioeaee ye ieneoioeei ? aacii?anei
oaeiae iiaeooue aooe ?aeiiaiaeiaai? aeey ee?i?/ii? ai?iaaoe?? i?e
e?eoaaii? aanoeiaioiiai neiae?iio.

Aeaniee aianie aaoi?a caeeth/a?oueny a naiino?eiiio i?iaaaeaii? an?o
aenia?eiaioaeueieo aeine?aeaeaiue, aiae?c? e?oa?aoo?ieo aeaieo,
noaoenoe/i?e ia?iaoe? oa aiae?c? aeanieo ?acoeueoao?a, ?ic?iaoe?
iniiaieo iieiaeaiue oa aeniiae?a ?iaioe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eio
?iaioo aeeiiaii o ?one? iaoeiai-aeine?aeii? oaiaoeee a?aeae?eo
iae?ioa?iaeieia?? ?inoeoooo oa?iaeieia??? oa oieneeieia?? AII Oe?a?ie,
oaie AeEIO ? 72 (oeo? 01.12.03/003-94 iae?iiaioeaee) “Aeine?aeaeaiiy
iae?iiaioeaeieo oa a?eueii?aaeeeaeueieo iaoiaaiaoe/ieo iaoai?ci?a
?icaeoeo ia?eiiai??” (1994-1995 ??., ? aea?ae?a?no?aoe?? 0195U011279),
oaie AII Oe?a?ie ? 4 (oeo? AII.10.0004.95) “Iae?iiaioeaei? oa
a?eueii?aaeeeaeuei? iaoai?cie aanoeiaioiiai neiae?iio i?e ii?ei?e
ia?eiiai?? ? ?ic?iaea iaoiae?a e?eoaaiiy aeaiiai iaoieia?/iiai noaio”
(1995-1997 ??., ? aea?ae?a?no?aoe?? 0195U010053), oaie AII Oe?a?ie ? 6
“Ania?eiaioaeueia iaa?oiooaaiiy eoie?oaaiiy aanoeiaioiiai neiae?iio i?e
ii?o?iia?e ia?eiiai?? oeyoii aieeao ia ii?aoi? ?aoeaioi?e” (1996-1998
??., ? aea?ae?a?no?aoe?? 0196U003295).

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? iioae?eiaaii o 10 ae?oeiaaieo
?iaioao (5 noaooyo oa 5 oacao aeiiia?aeae), o oiio /ene? 7 naiino?eieo.
?acoeueoaoe aeine?aeaeaiue aeiiia?aeaeenue ia can?aeaiiyo Ia?oiai
iaoe?iiaeueiiai c’?caeo oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie
oa?iaeieia??” (Iieoaaa, 1995), Ia?oi? Ana?in?enueei? eiioa?aioe??
oieneeieia?a “Aeooaeueiua i?iaeaiu oai?aoe/aneie e i?eeeaaeiie
oieneeieiaee” (Naieo-Iaoa?ao?a, 1995), 1-ai I?aeia?iaeiiai iaaee/iiai
Eiia?ano nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1997), Ia?oiai
iaoe?iiaeueiiai eiia?ano iaa?ieia?a, ineo?ao??a oa ia?eieia?a Oe?a?ie
(Oa?e?a, 1997), 2-ai I?aeia?iaeiiai iaaee/iiai Eiia?ano nooaeaio?a ?
iieiaeeo a/aieo (Oa?iii?eue, 1998).

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe. ??oaiiyi Oa?iaeieia?/iiai eii?oaoo
IIC Oe?a?ie (i?ioieie ? 10 a?ae 25.12.97) aeicaieaii i?iaaaeaiiy
ee?i?/ieo aei?iaoaaiue i?aia?aoo aaeeioai ca iiaei i?ecia/aiiyi aeey
e?eoaaiiy aanoeiaioiiai neiae?iio o oai?eo ia ii?eio ia?eiiai?th.

No?oeoo?a oa ia’?i aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, ?icae?eo “Iaoa??aee oa iaoiaee aeine?aeaeaiue”,
aeanieo aenia?eiaioaeueieo aeine?aeaeaiue, iaaiai?aiiy io?eiaieo
?acoeueoao?a, caeeth/aiiy oa aeniiae?a. Ia’?i ?iaioe noaiiaeoue 191
noi??ieo iaoeiiieniiai oaenoo, ui aeeth/a? 17 ?enoie?a oa 30 oaaeeoeue.
Iieaciee e?oa?aoo?e ia? 247 iaeiaioaaiue, c yeeo 128 a?o/eciyieo oa 119
?iicaiieo aeaea?ae.

Iieiaeaiiy, ui aeiinyoueny ia caoeno.

1. Aanoeiaioiee neiae?ii i?e ii?o?iia?e caeaaeiino? iaoiiaeaiee
ii?ooaiiyie o ooieoe?iioaaii? iae?iiaae?aoi?ieo ? iae?iiaioeaeieo
nenoai, ui ?aaoeththoue aiioe?eio iiaaae?ieo.

2. Aanoeiaioiee neiae?ii ?icaeaa?oueny ia oii? iaiaaeaiiy ae?aiaciio
ooieoe?iiaeueieo iiaeeeainoae aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai.

3. I?e aanoeiaioiiio neiae?ii? a?aei?/a?oueny ??cea cieaeaiiy aeoeaiino?
na?ioii?ia?a?/ii? oa AAIE-a?a?/ii? nenoai.

4. I?e oi?ioaaii? aanoeiaioiiai neiae?iio a?aeaoaathoueny ci?ie o
aca?iiae?? ith-, aeaeueoa- oa eaiia-ii?aoieo ?aoeaioi??a.

5. O iaoiaaiac? aanoeiaioiiai neiae?iio iaaia ?ieue iaeaaeeoue
aacii?anei- oa ieneoioeeia?a?/iei iaii?i?aeiei iae?iiaioeaeiei nenoaiai.

6. Aeey onoiaiiy aanoeiaioiiai neiae?iio i?e ii?ei?e ia?eiiai?? ne?ae
i?iaiaeeoe eiiieaenio oa?iaeioa?ai?th c aeei?enoaiiyi oai?eao?eio*
(iacaoiio), aoaae?eio*, eaaiaeiie* (L-3,4-ae?ieneoai?eaeai?io),
L-o?eioioaio, aaeeioaio*, ieneoioeeio oa aacii?aneio.

Iniiaiee ci?no ?iaioe

iaoa??ae oa iaoiaee aeine?aeaeaiue

Aeine?aee i?iaaaeai? ia 713 noaoaaic??eeo iae?i?eieo a?eeo uo?ao-naioeyo
ianith 170-230 a ?icaaaeaiiy ?inoeoooo oa?iaeieia?? oa oieneeieia?? AII
Oe?a?ie. Oaa?ei oo?eioaaee ia noaiaea?oiiio aiaeii-oa?/iaiio ?aoe?ii?
i?e a?eueiiio aeinooi? aei aiaee oa ?ae?. C iaoith i?iaaaeaiiy
a?io?i?/ieo aeine?aeaeaiue uo??a aeaeai?ooaaee, ?ioeo oaa?ei aeaiaeeee c
aeine?aeo oeyoii iii?uaiiy ?o a eaia?o c aoiinoa?ith, iane/aiith ia?aie
iaaee/iiai ao??o.

O?ce/io caeaaei?noue a?ae ii?o?io a?ae?ioei?eaeo aeeeeeaee oeyoii
uiaeaiieo aeai?aciaeo (i 10.00 oa 18.00) ?io?aia?eoiiaaeueieo (?/i)
?i’?eoe?e ia?eioeea a c?inoath/eo aeicao (ia 5 ia/ea iane o?ea
uiaeiaiai) a?ae 5 aei 65 ia/ea (N.E.Noaeaeia e ae?., 1994).
Aenia?eiaioaeueiee aanoeiaioiee neiae?ii aeeeeeaee aaaaeaiiyi
ii?o?icaeaaeiei oaa?eiai aioaaii?noa ii?aoieo ?aoeaioi??a iaeieniio (?/i
a aeic? 1 iaea ca 30 oa aei niinoa?aaeaiiy) aai i?eieiaiiyi aaaaeaiiy
ii?o?io (aeine?ae ii/eiaee /a?ac 16 aiae i?ney inoaiiuei? ?i’?eoe??).
Oyaee?noue aanoeiaioe?? ioe?ithaaee ca 11 ee?i?/ieie i?iyaaie neiae?iio
oeyoii a?coaeueiiai niinoa?aaeaiiy ia i?ioyc? 3 oa ? ae?aaeaee
?iaeaenii aanoeiaioe?? a aaeao.

Ai?no ii?aae?aiae?io, aeioai?io, na?ioii?io oa o?eioioaio a a?iioaeaion?
oa ei?? aaeeeeo i?aeoeue aieiaiiai iiceo uo??a aecia/aee iaoiaeii
aenieiaoaeoeaii? ??aeeiii? o?iiaoia?ao?? c aeei?enoaiiyi HPLC “System
346” (eieiiea “Ultrasphere ODS” 4,6 o 250, aeaoaeoi?-oethi?eiao? c
aeiaaeeiith oaee? caoaeaeaiiy 200 ii) (W.A.Hunt, O.E.Dalton, 1983).
Oaa?ei aeaeai?ooaaee /a?ac 30 oa i?ney aaaaeaiiy a?aeiia?aeii? ?a/iaeie
(?ic/eiieea — aiaee aeey ?i’?eoe?e, ii?o?io aai iaeieniio).

sse noaiaea?oe aeei?enoiaoaaee ?ic/eie ii?aae?aiae?io, aeioai?io,
na?ioii?io (“Sigma”), DL-o?eioioaio (“Reanal”) a eiioeaio?aoe?? 1-5
ia/100 ie 0,1 I oei?ii? eeneioe, ye? ia?aae aeine?aeaeaiiyi ?icaiaeeee
aei iaiao?aeii? eiioeaio?aoe?? (1:1000).

Oa?iaeieia?/iee aiae?c iae?iiaae?aoi?ieo oa iae?iiaioeaeieo nenoai
i?iaiaeeee c ____________

* — iaaaaeaia i?aeia?iaeia iaiaoaioiaaia iacaa

aeei?enoaiiyi i?aia?ao?a oa ?a/iaei, ui naeaeoeaii ae?thoue ia ??ci?
eaiee neiaioe/ii? ia?aaea/?, cie?aia aae?aii-, aeioai?ii-, na?ioii?ii-,
AAIE-, oie?ii- oa ii?aoii? nenoai (oaae. 1). Ioe?ithaaee aieea
iiia?aaeiueiai aaaaeaiiy oa?iaeieia?/ieo aiae?caoi??a ye ia cia/aiiy
?iaeaena aanoeiaioe?? a oe?eiio, oae ? iniaeeaino? ee?i?/ii? ea?oeie
neiae?iio a?aeiyooy. An? ?a/iaeie, e??i aooi?oaiieo, aaiaeeee ?/i.

Io?eiai? ?acoeueoaoe ia?iaeyee ca aeiiiiiaith i?ia?aiiiai i?iaeoeoo
“Statgraf”, ioe?ieo a??ia?aeiino? a?aei?iiinoae i?iaiaeeee c
aeei?enoaiiyi t — e?eoa??y No’thaeaioa oa — eiao?oe??ioa ?aiaiai?
ei?aeyoe?? Ni??iaia (I.I.Ieioea? e ae?., 1991).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

Iiiiai?ia?a?/ia nenoaia. ?acoeueoaoe aeine?ae?a aeicaieeee c?iaeoe
aeniiaie, ui ?icaeoie caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai
neiae?iio noi?iaiaeaeothoueny cieaeaiiyi ae?aiaciio ooieoe?iiaeueieo
iiaeeeainoae ?aaaoaaiiy aae?aia?a?/ii? nenoaie. I?i oea na?ae/eoue
a?aenooi?noue ci?i i?ney o?eaaeiai canoinoaaiiy ii?o?io a a?iioaeaion?
oa ei?? (oaae. 2, 3), oiae? ye iaeii?aciaa aaaaeaiiy ii?o?io aeeeeea?
i?aeaeuaiiy ??aiy ii?aae?aiae?io a ei?? (oaae. 3).

Aaaaeaiiy ia oeueiio oii? noeioeyoi??a aae?aia?a?/ii? nenoaie aoaae?eio
a aeic? 2 ia/ea (niiioaiia aanoeiaioe?y) aai aaii?noa
1-aae?aii?aoeaioi??a oai?eao?eio (iacaoiio) a aeic? 1 ia/ea ca 1 aiae
aei niinoa?aaeaiiy (iaeieniiiaa aanoeiaioe?y) cieaeoaaei ae?aaeai?noue
ee?i?/ieo i?iya?a aanoeiaioiiai neiae?iio. ?iaeaen aanoeiaioe?? i?e
oeueiio aeinoia??ii cieaeoaaany ia 74,5% oa 38,6% a?aeiia?aeii. Ii?yae c
oeei aaaaeaiiy aioaaii?noa 1-aae?aii?aoeaioi??a i?aciceio a aeic? 0,5
ia/ea ca 1 aiae aei niinoa?aaeaiiy (niiioaiia aanoeiaioe?y) iia??ooaaei
ia?aa?a aanoeiaioiiai neiae?iio — ?iaeaen aanoeiaioe?? ca?eueooaaany ia
77,8%. Aaaaeaiiy ii?o?icaeaaeiei oaa?eiai aaii?noa 2-aae?aii?aoeaioi??a
eeii?aeeio a aeic? 0,1 ia/ea ca 1 aiae aei niinoa?aaeaiiy (iaeieniiiaa
aanoeiaioe?y) ia aieeaaei ia oyaee?noue aanoeiaioiiai neiae?iio.

Oe? ?acoeueoaoe i?aeoaa?aeaeothoue aeniiaie uiaei ?icaeoeo aanoeiaioe??
ia oii? iaiaaeaiiy ooieoe?iiaeueieo iiaeeeainoae aae?aia?a?/ii? nenoaie.
I?e oeueiio a?eueo aaaeeeaa cia/aiiy ia? 1-aae?aia?a?/ia eaiea
aeine?aeaeoaaii? iae?iiaae?aoi?ii? nenoaie.

I?e oi?ioaaii? caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai neiae?iio
niinoa??aaee oaeiae cieaeaiiy ae?aiaciio ooieoe?iiaeueieo iiaeeeainoae
?aaaoaaiiy aeioai?ia?a?/ii? nenoaie ia aaaaeaiiy ia?eioeea. I?i oea
na?ae/aoue aeai? uiaei ai?noo aeioai?io a a?iioaeaion? aieiaiiai iiceo
oaa?ei (oaae. 2). Oae, iaeii?aciaa aaaaeaiiy ii?o?io ia ci?ithaaei ??aiy
oeueiai iae?iiaae?aoi?a. Ia 5 aeiao aaaaeaiiy ia?eioeea ai?no aeioai?ia
a a?iioaeaion? ciaiooaaany, iaeiae caeeoaany aac ci?i a ?io? oa?i?ie
oi?ioaaiiy caeaaeiino?, a oaeiae i?e ?icaeoeo aanoeiaioiiai neiae?iio.

Oaaeeoey 1

Ia?ae?e aeei?enoaieo a ?iaio? oa?iaeieia?/ieo aiae?caoi??a

??

i/iNenoaiaIacaa ?a/iaeieOa?iaeieia?/ia ae?yAeei?enoaia aeica,
ia/ea1.Aae?aia?a?/iaAoaae?eiIai?yiee aae?aiii?iaoee2,02.- “
-I?aciceiAeieaoi? 1-aae?aii?aoeaioi??a 0,53.- “ -Oai?eao?eiAaii?no
1-aae?aii?aoeaioi??a1,04.- “ -Eeii?aeeiAaii?no
2-aae?aii?aoeaioi??a0,15.Aeioai?ia?a?/iaEaaiaeiiaI?aeo?ni?
aeioai?io2006.- “ -Aiiii?o?iAaii?no ?aoeaioi??a1,07.- “
-Aaeiia?eaeieAeieaoi?
?aoeaioi??a1,08.Na?ioii?ia?a?/iaL-o?eioioaiI?aeo?ni? na?ioii?io809.- “
-Iaoeca?a?aeAeieaoi? ?aoeaioi??a0,510.AAIEa?a?/iaIonoeeiieAaii?no
AAIEA-?aoeaioi??a1,011.- “ -AaeeioaiAaii?no AAIEA-?aoeaioi??a2,012.- “
-A?eoeoe?iAeieaoi? AAIEA-?aoeaioi??a1,013.- “ -O?inaieea?aaceaeAeieaoi?
neioaca AAIE3,014.Oie?ia?a?/iaAaeaioai?iOeaio?aeueiee iai?yiee
oie?iii?iaoee

(aeieaoi? oeaio?aeueii? aoeaoeeoie?ianoa?ace)2,015.- “
-Iaoai?ceeAeieaoi? oeaio?aeueieo
I-oie?ii?aoeaioi??a5,016.Ii?aoiaIi?o?iAaii?no ith- oa eaiia-ii?aoieo
?aoeaioi??a9,017.- “ -Aooi?oaiie Aaii?no eaiia-ii?aoieo ?aoeaioi??a oa
ci?oaiee aaii?no-aioaaii?no ith-ii?aoieo ?aoeaioi??a27,018.- “
-O?aiaaeieAaii?no ith-ii?aoieo ?aoeaioi??a14,019.- “ -Eiia?ai?aeAaii?no
ia?eoa??eieo ith-ii?aoieo ?aoeaioi??a15,0

Oaaeeoey 2

Ai?no iiiiai?i?a o a?iioaeaion? aieiaiiai iiceo uo??a i?e ?icaeoeo
caeaaeiino? a?ae ii?o?io oa aanoeiaioe??

(iea/a ne?i? oeaieie)

Oiiae aeine?aeo

Ii?aae?aiae?i

Aeioai?i

Na?ioii?i

O?eioioaieiio?ieueaeine?aeeiio?ieue aeine?aeeiio?ieueaeine?aeeiio?ieue

aeine?aeIi?o?i iaeii?aciai

(9 ia/ea)1,06 0,08

n = 8

1,02 0,07

n = 82,32 0,15

n = 82,63 0,08

n = 81,92 0,15

n = 81,73 0,12

n = 83,17 0,20

n = 83,55 0,20

n = 8Caeaaei?noue, 5-a aeiaa (ii?o?i a aeic? 25 ia/ea)1,18 0,10

n = 8

1,04 0,06

n = 82,73 0,10

n = 82,36 0,14*

n = 82,20 0,12

n = 81,95 0,21

n = 82,60 0,20

n = 82,90 0,29

n = 6Caeaaei?noue, 9-a aeiaa (ii?o?i a aeic? 45 ia/ea)1,00 0,03

n = 8

0,91 0,06

n = 82,06 0,15

n = 81,90 0,12

n = 81,59 0,08

n = 81,25 0,12*

n = 82,09 0,21

n = 82,07 0,15

n = 8Caeaaei?noue, 13-a aeiaa (ii?o?i a aeic? 65 ia/ea)1,45 0,10

n = 81,55 0,13

n = 81,69 0,25

n = 81,81 0,19

n = 83,23 0,49

n = 81,39 0,17*

n = 83,06 0,33

n = 63,34 0,27

n = 7Aanoeiaioe?y

(iaeienii a aeic? 1 ia/ea)1,55 0,13

n = 81,62 0,12

n = 81,81 0,19

n = 82,29 0,15

n = 81,39 0,17

n = 81,63 0,23

n = 83,34 0,27

n = 72,09 0,16*

n = 7

I?ei?oee :

1. — * ? < 0,05 ii a?aeiioaiith aei iieaciee?a eiio?ieueii? a?oie. 2. - n - e?euee?noue oaa?ei. Oaaeeoey 3 Ai?no iiiiai?i?a a ei?? aaeeeeo i?aeoeue aieiaiiai iiceo uo??a i?e ?icaeoeo caeaaeiino? a?ae ii?o?io oa aanoeiaioe?? (iea/a ne?i? oeaieie) Oiiae aeine?aeo Ii?aae?aiae?i Aeioai?i Na?ioii?i O?eioioaieiio?ieueaeine?aeeiio?ieue aeine?aeeiio?ieueaeine?aeeiio?ieue aeine?aeIi?o?i iaeii?aciai (9 ia/ea)0,27 0,01 n = 8 0,36 0,04* n = 8000,89 0,13 n = 80,72 0,11 n = 82,81 0,17 n = 82,79 0,16 n = 8Caeaaei?noue, 5-a aeiaa (ii?o?i a aeic? 25 ia/ea)0,35 0,04 n = 8 0,42 0,02 n = 8000,92 0,10 n = 80,93 0,13 n = 82,34 0,09 n = 82,76 0,24 n = 6Caeaaei?noue, 9-a aeiaa (ii?o?i a aeic? 45 ia/ea)0,36 0,02 n = 8 0,38 0,02 n = 8000,80 0,05 n = 80,64 0,04* n = 81,72 0,16 n = 81,92 0,18 n = 6Caeaaei?noue, 13-a aeiaa (ii?o?i a aeic? 65 ia/ea)0,47 0,06 n = 80,45 0,07 n = 8001,20 0,28 n = 81,36 0,40 n = 82,80 0,24 n = 73,26 0,33 n = 6Aanoeiaioe?y (iaeienii a aeic? 1 ia/ea)0,45 0,07 n = 80,49 0,09 n = 8001,36 0,40 n = 80,68 0,15* n = 83,26 0,33 n = 71,84 0,07* n = 7 I?ei?oee : 1. -* ? < 0,05 ii a?aeiioaiith aei iieaciee?a eiio?ieueii? a?oie. 2. - n - e?euee?noue oaa?ei. oaa?ei c aanoeiaioe??th, aeeeeeaiith aaaaeaiiyi iaeieniio, - iaeaeaa i?aia?aoe cieaeoaaee ?iaeaen aanoeiaioe?? ia 59,1%. Ia i?ioeaaao oeueiio aaaaeaiiy aeieaoi?a aeioai?iiaeo ?aoeaioi??a aaeiia?eaeieo a aeic? 1 ia/ea ca 1 aiae aei niinoa?aaeaiiy (iaeieniiiaa aanoeiaioe?y) ca?eueooaaei oeae iieaciee ia 56,7%. I?e ?icaeoeo aanoeiaioiiai neiae?iio niinoa??aa?oueny cieaeaiiy aeoeaiino? na?ioii?ia?a?/ii? nenoaie. Oae, ??aaiue na?ioii?io a iiceo cieaeoaaany ia 9 oa 13 aeiao aaaaeaiiy ii?o?io, oiaoi o no?iee oi?ioaaiiy caeaaeiino? aei ia?eioeea (oaae. 2, 3). Aanoeiaioiee neiae?ii oaeiae noi?iaiaeaeoaaany cieaeaiiyi ai?noo na?ioii?io, ui iiaea aooe iaoiiaeaia ciaioaiiyi ai?noo iiia?aaeieea iae?iiaae?aoi?a - ai?iieeneioe o?eioioai (oaae. 2, 3). Aaaaeaiiy ii?o?icaeaaeiei oaa?eiai L-o?eioioaio a aeic? 80 ia/ea ca 1,5 aiae aei niinoa?aaeaiiy (iaeieniiiaa aanoeiaioe?y) cieaeoaaei ?iaeaen aanoeiaioe??, ui na?ae/eoue i?i aacoiiaio o/anoue oe??? iae?iiaae?aoi?ii? nenoaie a iaoai?ci? ?icaeoeo aanoeiaioiiai neiae?iio. Oaeei /eiii, ?icaeoie caeaaeiino? a?ae ii?o?io ? aanoeiaioiiai neiae?iio ? neeaaeiei aaaaoieiiiiiaioiei i?ioeanii, aei ia?aa?ao yeeo i?e/aoi? na?ioii?ia?a?/ia, aeioai?ia?a?/ia oa aae?aia?a?/ia nenoaie. Iaie aeyaeaii, ui i?e ?icaeoeo caeaaeiino? oa aanoeiaioiiio neiae?ii? i?ae oeeie nenoaiaie a a?iioaeaion? ooai?ththoueny aei?noe? ei?aeyoe?ei? ca’ycee (P < 0,05), ye? iiaeooue iaiaaeoaaoe ??aaiue aaeaioaoe?? i?aai?cio aei iiaeo oiia ?nioaaiiy. Oea i?eiouaiiy a?oioo?oueny ia oiio, ui, ii-ia?oa, o ?ioaeoieo oaa?ei oaei? e?eueeino? ca’yce?a ia aeyaeaii, ii-ae?oaa, o oaa?ei a oeae oa?i?i c’yaeythoueny ii?ooaiiy iiaaae?iee i?ney aaaaeaiiy ia?eioeea (a?ia?aeoeai?noue, aa?aneai?noue, ii?aeaiiy oe?ne),a oaeiae ?icaeaa?oueny oiea?aioi?noue aei aiaeueaaoe/ii? ae?? ii?o?io. Iiaeia i?eionoeoe, ui iiyaa oaei? e?eueeino? ei?aeyoe?e iia’ycaia c iiaei, iaoieia?/iei noaiii i?aai?cio - noaiii o?ce/ii? caeaaeiino? a?ae ia?eioeea. Aeneiaeaia i?eiouaiiy ocaiaeaeo?oueny c a?iioacith E.B.Noaeaeiaa (1990), yeee iia’yco? ?icaeoie ia?eiiai?e c iiyaith iiai? o?i?/ii? ?ioaa?aoe?? i?ae iae?iiaae?aoi?ieie nenoaiaie iiceo. AAIE-a?a?/ia nenoaia. Oae, ye ? na?ioii?ia?a?/ia, AAIE-a?a?/ia nenoaia aeeiio? aaeuei?ai? ooieoe?? a ae?yeueiino? aieiaiiai iiceo, ianaiia?aae o oi?ioaaii? aiioe?eii? iiaaae?iee (A.E.Eoeeineee, A.A.Ieoaeuenii, 1998; A.A.Ooiaiiaa, 1989). Oa?iaeieia?/iee aiae?c iieacaa, ui aaaaeaiiy aaii?no?a AAIEA-?aoeaioi??a ionoeeiieo a aeic? 1 ia/ea ? AAIEA-?aoeaioi??a aaeeioaio a aeic? 2 ia/ea ca 30 oa aei niinoa?aaeaiiy (niiioaiia aanoeiaioe?y) aeinoia??ii cieaeoaaei ?iaeaen aanoeiaioe?? (ia 72,7% oa 83,3% a?aeiia?aeii). Aaaaeaiiy aioaaii?noo AAIEA-?aoeaioi??a a?eoeoe?io a aeic? 1 ia/ea ca 30 oa aei niinoa?aaeaiiy oa aeieaoi?a neioaco AAIE o?inaieea?aaceaeo a aeic? 3 ia/ea ca 4 aiae aei niinoa?aaeaiiy (niiioaiia aanoeiaioe?y) iineethaaei i?iyae aanoeiaioiiai neiae?iio. ?iaeaen aanoeiaioe?? i?e oeueiio i?aeaeuoaaany ia 32,2% oa 63,0% a?aeiia?aeii. Oie?ia?a?/ia nenoaia. Ca?aeii aeaieo e?oa?aoo?e, ii?aoia nenoaia aca?iiae?? c oie?ia?a?/iith (A.I.Aoeaaa, E.N.?aaaneee, 1982; A.A.Aaeueaeiai, 1972; A.I.Aaoeaiei, 1989; E.A.A?iiia e ae?., 1984; I.TH.Ia?ea?iaa, 1987; N.A.Io?aiaae/, 1993; A.I.No?oiaineay, 1989). Iaeiae, ye iieacaee iao? aeine?aee, i? aeoeaaoi? ooieoe?iioaaiiy oie?ia?a?/ii? nenoaie aaeaioai?i a aeic? 2 ia/ea, i? aeieaoi? iaoai?cee a aeic? 5 ia/ea, ui aoee aaaaeai? ca 30 oa aei niinoa?aaeaiiy, ia aieeaaee ia ia?aa?a aanoeiaioiiai neiae?iio. Ii?aoia nenoaia. A?aeiii, ui ia?eioe/i? aiaeueaaoeee, a oiio /ene? ? ii?o?i, cae?eniththoue na?e oa?iaeieia?/iee aieea /a?ac ?o aca?iiae?th c ii?aoieie ?aoeaioi?aie (E.A.A?iiia, 1992; B.N.Dhawan et al., 1996). O ca’yceo c oeei ai??i?? iiaeia aaaaeaoe, ui ?icaeoie aanoeiaioiiai neiae?iio iia’ycaiee ?c caeo/aiiyi aei iaoieia?/iiai i?ioeano ??cieo iiioeyoe?e ii?aoieo ?aoeaioi??a. Oea iieiaeaiiy i?aeoaa?aeaeo?oueny, cie?aia, aenieith oa?aiaaoe/iith aoaeoeai?noth i?e ciyoo? neiioii?a aanoeiaioe?? aaii?noa ith- oa eaiia-ii?aoieo ?aoeaioi??a ii?o?io, aaii?noa ith-ii?aoieo ?aoeaioi??a iaoaaeiio, ui aeicaiey? aeei?enoiaoaaoe iaoaaeii c oe??th iaoith a ee?i?oe? (I.I.Eaaiaoe, 1990). Iaeiae, iaoaaeii caeaoiee aeeeeeaoe aeoi??th, ineo?/io oa o?ce/io caeaaei?noue (R.Jasinski, K.Preston, 1986). O ca’yceo c oeei ie iaiaaaeenue na?aae i?aia?ao?a, ui ae?thoue ia ii?aoi? ?aoeaioi?e, aea?aoe o?, ye? a aoaeoeaii eoie?iaaee aanoeiaioiee neiae?ii ? ia aeeeeeaee i?e oeueiio caeeaiiy. C ?ioiai aieo, ie noaaeee ia?aae niaith caaaeaiiy i?iaanoe aiae?c o/ano? ??cieo iiioeyoe?e ii?aoieo ?aoeaioi??a o iaoiaaiac? aanoeiaioiiai neiae?iio. C oe??th iaoith aoei aeine?aeaeaii aieea aaii?noa eaiia-ii?aoieo ?aoeaioi??a oa ci?oaiiai aaii?noa/aioaaii?noa ith-ii?aoieo ?aoeaioi??a aooi?oaiieo (a aeic? 27 ia/ea noaeooaiii ca 60 oa aei niinoa?aaeaiiy), aaii?noa ith-?aoeaioi??a o?aiaaeieo (14 ia/ea ?/i ca 30 oa aei niinoa?aaeaiiy), aaii?noa ia?eoa??eieo ith-ii?aoieo ?aoeaioi??a eiia?ai?aeo (15 ia/ea ?/i ca 30 oa aei niinoa?aaeaiiy) ia ia?aa?a ii?eiiai aanoeiaioiiai neiae?iio, aeeeeeaiiai iaeieniiii. Aeine?aee iieacaee, ui eiia?ai?ae ? aooi?oaiie cieaeoaaee ?iaeaen aanoeiaioe?? (ia 51,2% oa 50,7% a?aeiia?aeii), oiae? ye o?aiaaeie ia ci?ithaaa oeae iieaciee. Io?eiai? ?acoeueoaoe oa aeai? e?oa?aoo?e na?ae/aoue i?i oa, ui o iaoiaaiac? ?icaeoeo aanoeiaioiiai neiae?iio aaaeeeaa cia/aiiy iathoue ii?ooaiiy ooieoe?iioaaiiy oa aca?iiae?? ith-, eaiia- oa aeaeueoa-ii?aoieo ?aoeaioi??a. Iaii?i?aei? iae?iiaioeaee. O oi?ioaaii? aiioe?eii? iiaaae?iee i?eeiathoue o/anoue ia o?eueee eeane/i? iae?iiaae?aoi?i? nenoaie oa ii?i?aei? iae?iiaioeaee, aea e a?iio?ca?ii-a?iioaeai?/i? iae?iiaioeaee iaii?i?aeii? i?e?iaee, cie?aia, ieneoioeei, aacii?anei, o??ie?aa?ei, I?O (E.A.A?iiia, 1992; E.A.A?iiia, 1996). O ca’yceo c oeei aoa i?iaaaeaiee aiae?c iiaeeeai? ?o o/ano? o iaoiaaiac? aanoeiaioiiai neiae?iio. I?iaaaeai? aeine?aeaeaiiy iieacaee, ui aacii?anei a aeicao 0,0015 ia/ea (i?eaeecii 0,5 IAe/ea) oa 0,015 ia/ea (i?eaeecii 5,0 IAe/ea) ?/i ca 1 aiae aei niinoa?aaeaiiy cieaeoaaa ?iaeaen aanoeiaioe?? (39,9% oa 53,4% a?aeiia?aeii), yeui aanoeiaioe?y aoea aeeeeeaia oeyoii a?aeiyooy a?ae ii?o?io, ? ia aieeaaa ia ia?aa?a aanoeiaioe??, yeui aiia aoea aeeeeeaia aaaaeaiiyi iaeieniio. Iiaeia i?eionoeoe, ui aeey ?aae?caoe?? oa?aiaaoe/iiai aoaeoo aacii?aneio iaei??th c iaiao?aeieo oiia ? a?euei? ii?aoi? ?aoeaioi?e. Aaaaeaiiy ii?o?icaeaaeiei oaa?eiai c aanoeiaioe??th, aeeeeeaiith iaeieniiii, ieneoioeeio a aeic? 5 IAe/ea (?/i ca 1 aiae aei niinoa?aaeaiiy) cieaeoaaei ?iaeaen aanoeiaioe?? ia 59,3%. Aaaaeaiiy oaeeo iae?iiaioeae?a, ye I?O (iaeaiinoaoei) a aeicao 0,001 ia/ea oa 0,1 ia/ea ?/i ca 1 aiae aei niinoa?aaeaiiy (niiioaiia aanoeiaioe?y) ? o??ie?aa?eio a aeic? 20 ia/ea ?/i ca 1 aiae aei niinoa?aaeaiiy (iaeieniiiaa aanoeiaioe?y) ia aieeaaei ia ee?i?/i? i?iyae aanoeiaioiiai neiae?iio. Oe?eaai, ui I?O ? N-e?ioeaaei o?eiaioeaeii iieaeoee ieneoioeeio, ? naia I?O, ia a?aei?io a?ae ieneoioeeio, ia aieeaa? ia ia?aa?a aanoeiaioiiai neiae?iio. Ioaea, iiaeia i?eionoeoe, ui aioeaanoeiaioia ae?y aecia/a?oueny ia an??th iieaeoeith ieneoioeeio, a eiai N-e?ioeaaei o?aaiaioii. caeeth/aiiy Oaeei /eiii, ?acoeueoaoe i?iaaaeaii? ?iaioe, a oaeiae aeai? e?oa?aoo?e na?ae/aoue i?i oa, ui ?icaeoie aanoeiaioe?? - oea aaaaoieaioethaiaee i?ioean, o oi?ioaaii? yeiai aaaeeeaa cia/aiiy iathoue ii?ooaiiy ooieoe?iioaaiiy eeane/ieo iae?iiaae?aoi?ieo nenoai, ??cieo iiioeyoe?e ii?aoieo ?aoeaioi??a oa iaii?i?aeieo iae?iiaioeae?a (Ae.I.Aeeeaei, A.A.Aeai?ieeia, 1991; A.A.Aaeueaeiai e ae?., 1988; N.A.Caeoeaa e ae?., 1986; ?.O.Ea?aaeiia, 1989; A.O.Iaua?yeia, N.E.Noaeaeia, 1991; S.D.Glick et al., 1992; M.J.Hepburn et al., 1997). Io?eiai? aenia?eiaioaeuei? aeai? aeicaieeee iia’ycaoe ?icaeoie aanoeiaioiiai neiae?iio c iaiaaeaiiyi ooieoe?iiaeueieo iiaeeeainoae aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai, a oaeiae cieaeaiiyi ooieoe?iiaeueii? aeoeaiino? na?ioii?ia?a?/ii?, AAIE-a?a?/ii? iae?iiaae?aoi?ieo nenoai oa aacii?anei- ? ieneoioeeia?a?/ieo iae?iiaioeaeieo nenoai. Oaeei /eiii, i?iaaaeai? aeine?aeaeaiiy na?ae/aoue i?i neeaaei?noue ? iae?io?i?/io aaoa?iaaii?noue iaoiaaiaco ii?eii? ia?eiiai??, yea iaoiiaeth? iaiao?aei?noue aeei?enoaiiy eiiieaeno e?ea?nueeeo cania?a, ae?y yeeo iai?aaeaia ia an? eaiee iaoieia?/iiai i?ioeano. Aeniiaee 1. ?icaeoie aanoeiaioiiai neiae?iio o ii?o?icaeaaeieo oaa?ei ? aaaaoieiiiiiaioiei i?ioeanii, iaoai?cie oi?ioaaiiy yeiai cia/iith i??ith iia’ycai? c ii?ooaiiyi iai?io oa ooioe?iioaaiiy ii?i?aeii? oa iaii?i?aeii? iae?iiaioeaeieo, a oaeiae iiiiai?ia?a?/ii? oa AAIE-a?a?/ii? nenoai. 2. Oiea?aioi?noue aei ii?o?io, o?ce/ia caeaaei?noue oa ii?o?iiaee aanoeiaioiee neiae?ii oi?iothoueny ia oii? iaiaaeaiiy ae?aiaciio ooieoe?iiaeueieo iiaeeeainoae (?ea?aeiino?) aae?aia?a?/ii? oa aeioai?ia?a?/ii? nenoai. Ia a?aei?io a?ae aino?iai (iaeii?aciaiai) aieeao ii?o?io, i?e aeacaieo iaoieia?/ieo noaiao ??aaiue ii?aae?aiae?io ? aeioai?io ia ci?ithaaany a a?iioaeaion? oa ei?? aieiaiiai iiceo. 3. Aae?aiii?iaoee aoaae?ei ? aaii?no 1-aae?aii?aoeaioi??a oai?eao?ei ciaioo? ?iaeaen aanoeiaioe??, oiae? ye aioaaii?no 1-aae?aii?aoeaioi??a i?acicei iineeth? ee?i?/i? i?iyae aanoeiaioiiai neiae?iio. Aaii?no 2-aae?aii?aoeaioi??a eeii?aeei ia aieeaa? ia ae?aaeai?noue aanoeiaioe??. 4. Iiia?aaei? aaaaeaiiy i?aeo?ni?a aeioai?io eaaiaeiie aai aaii?noa aeioai?iiaeo ?aoeaioi??a aiiii?o?io cieaeo? ?iaeaen aanoeiaioe??, i?eai?/aiiy iae?iiaae?aoi?ii? nenoaie oeyoii canoinoaaiiy aeieaoi?a aeioai?iiaeo ?aoeaioi??a aaeiia?eaeieo iia??oo? ia?aa?a aanoeiaioiiai neiae?iio. 5. Aeoeai?noue na?ioii?ia?a?/ii? nenoaie i?e aanoeiaioiiio neiae?ii? ciaioo?oueny ca ?aooiie cieaeaiiy ??aiy na?ioii?io oa eiai iiia?aaeieea o?eioioaio a iiceo. 6. Aeoeaaoe?y na?ioii?ia?a?/ieo i?ioean?a oeyoii nenoaiiiai aaaaeaiiy iiia?aaeieea na?ioii?io ai?iieeneioe L-o?eioioai cieaeo? ?iaeaen aanoeiaioe??, oiae? ye i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? oeyoii aaaaeaiiy aeieaoi?a na?ioii?iiaeo ?aoeaioi??a iaoeca?a?aeo ia aieeaa? ia ae?aaeai?noue aanoeiaioe??. 7. Aaii?noe AAIE-?aoeaioi??a aaeeioai ? ionoeeiie cia/iith i??ith cieaeothoue ae?aaeai?noue ee?i?/ieo i?iya?a aanoeiaioe??, oiae? ye aioaaii?no AAIE-?aoeaioi??a a?eoeoe?i oa ?ia?a?oi? neioaco aaia-ai?iiianeyii? eeneioe o?inaieea?aaceae ??cei iia??oothoue o?ce/iee noai oaa?ei c aanoeiaioe??th, ui na?ae/eoue i?i aacoiiaio o/anoue AAIE-a?a?/ii? nenoaie a ?icaeoeo aanoeiaioiiai neiae?iio. 8. Aooi?oaiie oa ii?o?i - i?aia?aoe, ui ae?thoue ia ith- oa eaiia-ii?aoi? ?aoeaioi?e - cieaeothoue ?iaeaen aanoeiaioe??, oiae? ye naeaeoeaiee oeaio?aeueiee aaii?no ith-ii?aoieo ?aoeaioi??a ia aieeaa? ia oeae iieaciee. Oea aea? i?aenoaae aeey i?eiouaiiy, ui a iaoai?ci? ?icaeoeo aanoeiaioiiai neiae?iio aaaeeeaa cia/aiiy iathoue ci?ie aca?iiae?? aeacaieo iiioeyoe?e ii?aoieo ?aoeaioi??a. 9. Eiia?ai?ae ciaioo? ae?aaeai?noue ee?i?/ieo i?iya?a aanoeiaioiiai neiae?iio oeaio?aeueiiai aaiaco, ui aea? i?aenoaae aeey ia?aaeyaeo oyaeaiue uiaei a?aeianaiiy i?aia?aoo aei naeaeoeaieo aaii?no?a ia?eoa??eieo ii?aoieo ?aoeaioi??a. 10. Iaii?i?aei? iae?iiaioeaee ieneoioeei oa aacii?anei cieaeothoue ?iaeaen aanoeiaioe??, ui na?ae/eoue i?i o/anoue ieneoioeei- ? aacii?aneia?a?/ii? nenoai o iaoiaaiac? ii?o?iiaiai aanoeiaioiiai neiae?iio. 11. A?aeiiee e?ea?nueeee can?a aaeeioai cai?iiiiiaaiee aeey aeei?enoaiiy ca iiaei i?ecia/aiiyi aeey e?eoaaiiy aanoeiaioiiai neiae?iio o oai?eo ia ii?eio ia?eiiai?th. Nienie iioae?eiaaieo aaoi?ii i?aoeue 1. O?eiiaiei I.A. No/ani? oyaeaiiy i?i iaoiaaiac ii?eieo ia?eiiai?e (iaeyae) // E?ee.- 1996.- ? 3. - N. 8-19. (?acii c A?iiiaei E.I., Na?aaeith I.?.) 2. O?eiiaiei I.A. Oa?iaeieia?/iee aiae?c iae?iiaae?aoi?ieo nenoai o oaa?ei c ii?eiei aanoeiaioiei neiae?iiii // E?ee.- 1996.- ? 3.- N. 19-22. 3. O?eiiaiei I.A. Iae?iiaae?aoi?i? iaoai?cie aanoeiaioiiai neiae?iio o ii?o?icaeaaeieo uo??a // Oe?. a?niee ineoiiaa?ieia??. - 1996. - O. 4, aei. 5 (12). - N.411-413. (?acii c A?iiiaei E.I.) 4. O?eiiaiei I.A. Aieea aeayeeo aaii?no?a oa aaii?no?a-aioaaii?no?a ii?aoieo ?aoeaioi??a ia ia?aa?a aanoeiaioiiai neiae?iio o ii?o?icaeaaeieo uo??a // E?ee.- 1997.- ? 3. - N. 77-79. 5. O?eiiaiei I.A. No/ani? iaoiaee e?eoaaiiy ii?eii? ia?eiiai?? (iaeyae) // E?ee.- 1997.- ? 4. - N. 42-45. (?acii c A?iiiaei E.I., Na?aaeith I.?., I?oaeai A.ss.) 6. O?eiiaiei I.A. Aieea o??ieeaa?eio ? ieneoioeeio ia ia?aa?a ii?eiiai aanoeiaioiiai neiae?iio o ii?o?icaeaaeieo a?eeo uo??a // Oac.aeii. I iaoe. c’?caeo oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie oa?iaeieia??”.- Iieoaaa, 1995.- N. 173. 7. O?eiiaiei I.A. AAIE-a?a?/i? iaoai?cie ii?eii? aanoeiaioe?? // Oac.aeii. I iaoe. c’?caeo oa?iaeieia?a Oe?a?ie “No/ani? i?iaeaie oa?iaeieia??”.- Iieoaaa, 1995.- N. 173. 8. Oeeiiaiei I.A. Iae?ioeie/aneea iaoaieciu ?acaeoey iieaoiie caaeneiinoe // Oac.aeii. I Ana?in?enueei? eiio. oieneeieia?a “Aeooaeueiua i?iaeaiu oai?aoe/aneie e i?eeeaaeiie oieneeieiaee”.- Naieo-Iaoa?ao?a, 1995.- O. I.- N. 91. 9. O?eiiaiei I.A. Aieea o?aiaaeiea ia ii?o?iiaee aanoeiaioiee neiae?ii // Oac. aeii. 1-ai I?aeia?iaeiiai iaaee/iiai Eiia?ano nooaeaio?a ? iieiaeeo a/aieo.- Oa?iii?eue, 1997. - N. 309. 10. O?eiiaiei I.A. Na?ioii?ia?a?/i? iaoai?cie ?icaeoeo o?ce/ii? caeaaeiino? a?ae ii?o?io // Oac. aeii. 2-ai I?aeia?iaeiiai iaaee/iiai Eiia?ano nooaeaio?a ? iieiaeeo a/aieo. - Oa?iii?eue, 1998. - N. 66-67. O?eiiaiei I.A. Iae?iiaae?aoi?i? oa iae?iiaioeaei? iaoai?cie ?icaeoeo aanoeiaioiiai neiae?iio o ii?o?icaeaaeieo oaa?ei. ?oeiien Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 14.03.06 - oieneeieia?y. - ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie, Ee?a, 1998. Aeine?aeaeoaaee iae?iiaae?aoi?i? oa iae?iiaioeaei? iaoai?cie ?icaeoeo caeaaeiino? a?ae ii?o?io oa aanoeiaioiiai neiae?iio. Anoaiiaeaii, ui o?ce/ia caeaaei?noue oa aanoeiaioiee neiae?ii ?icaeaathoueny ia oii? iaiaaeaiiy ?aaaoaaiiy aae?aia?a?/ii? oa aeioai?ia?a?/ii? neonai. A oie aea /an aeoeai?noue na?ioii?ia?a?/ii?, AAIE-a?a?/ii?, aacii?aneia?a?/ii? oa ieneoioeeia?a?/ii? nenoai i?e aanoeiaioiiio neiae?ii? i?eai?/aia. Iieacaii, ui aaii?noe ii?aoieo ?aoeaioi??a aooi?oaiie oa eiia?ai?ae cae?eniththoue iiceoeaiee aieea ia o?ce/iee noai oaa?ei c aanoeiaioe??th. Aiaeia?/io ae?th iathoue aeoeaaoi?e aae?aia?a?/ii? nenoaie (aoaae?ei, oai?eao?ei), aeioai?ia?a?/ii? nenoaie (eaaiaeiia, aiiii?o?i), na?ioii?ia?a?/ii? nenoaie (o?eioioai), a oaeiae iae?iiaioeaee aacii?anei oa ieneoioeei. Eeth/ia? neiaa: ii?o?i, caeaaei?noue, aanoeiaioe?y, iae?iiaae?aoi?e, iae?iiaioeaee Oeeiiaiei I.A. Iae?iiaaeeaoi?iua e iae?iiaioeaeiua iaoaieciu ?acaeoey aanoeiaoiiai neiae?iia o ii?oeicaaeneiuo aeeaioiuo. ?oeiienue Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 14.03.06 - oieneeieiaey. - Einoeooo oa?iaeieiaee e oieneeieiaee AII Oe?aeiu, Eeaa, 1998 Enneaaeiaaee iae?iiaaeeaoi?iua e iae?iiaioeaeiua iaoaieciu ?acaeoey caaeneiinoe io ii?oeia e aanoeiaioiiai neiae?iia. Onoaiiaeaii, /oi oece/aneay caaeneiinoue e aanoeiaioiue neiae?ii ?acaeaathony ia oiia ia?aie/aiey ?aaae?iaaiey aae?aia?ae/aneie e aeioaieia?ae/aneie nenoai. A oi aea a?aiy aeoeaiinoue na?ioiieia?ae/aneie, AAIE-a?ae/aneie, aacii?anneia?ae/aneie e ieneoioeeia?ae/aneie nenoai i?e aanoeiaioiii neiae?iia oaiaoaia. Iieacaii, /oi aaiienou iieaoiuo ?aoeaioi?ia aooi?oaiie e eiia?aieae ieacuaatho iieiaeeoaeueiia aeeyiea ia oece/aneia ninoiyiea aeeaioiuo n aanoeiaioiui neiae?iiii. Aiaeiae/iia aeeyiea ieacuaatho aeoeaaoi?u aae?aia?ae/aneie nenoaiu (yoaae?ei, oaieeyo?ei), aeioaieia?ae/aneie nenoaiu (eaaiaeiia, aiiii?oei), na?ioiieia?ae/aneie nenoaiu (o?eioioai) e iae?iiaioeaeu aacii?annei e ieneoioeei. Eeth/aaua neiaa: ii?oei, caaeneiinoue, aanoeiaioeey, iae?iiaaeeaoi?u, iae?iiaioeaeu Filonenko M.A. The neuromediator and neuropeptide mechanisms of the development of withdrawal syndrome on morphine dependent animals. The manuscript. The dissertation of the competition of biological sciences candidate degree on the speciality 14.03.06 - toxicology. The Institute of Pharmacology and Toxicology of the Academy of Medical Sciences of Ukraine, Kiev, 1998 The neuromediator and neuropeptide mechanisms of dependence on morphine and withdrawal syndrome were studied. It’s concluded that the physical dependence and abstinence were developed on the background of the limited range of adrenergic and dopaminergic systems. At the same time serotoninergic, GABA, vassopressin and oxytocin activity in withdrawal syndrome were inhibited. Possitive influence of agonists at opioid receptor Butorphalol and Loperamide on the physical state of abstinent animals was shown. The activators of adrenergic (Ephedrine, Phenylephrine), dopaminergic (Levodopa, Apomorphine), serotoninergic systems (Tryptophan) and neuropeptids vassopressin and oxytocin had the same activity. Key words: morphine, dependence, withdrawal syndrome, neuromediators, neuropeptides

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