OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

IAOIIAA Ieueaa Aieiaeeie??aia

OAeE: 616.61-053.1:[618.3-008.6-039.12+

616.379-008.64+616.611-002-036.12] (477.54)

II?OIOOIEOe?IIAEUeIEE NOAI IE?IE IEIAe?A A?Ae IAOA??A C I?CI?I AANOICII,
OeOE?IAEI Ae?AAAOII ? OEIO OA O?II?*IEI AEIIA?OEIIAO?EOII A OIIAAO
OA?E?ANUeEIAI ?AA?IIO.

14.03.02 – IAOIEIA?*IA AIAOII?ss

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
IIC Oe?a?ie.

Iaoeiaee ea??aiee — ae.i.i., i?ioani? Aioii?ia Oaaei??aia sseiaoeiaa,
caa?aeoaa/ eaoaae?ith iaoieia?/ii? aiaoii?? Oa?e?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo.

Iaoeiaee eiinoeueoaio – ae.i.i., i?ioani? AEaiia Aeieo??aia.
Nai?aeioeueea, caa?aeoaa/ eaoaae?ith i?iiaaeaaoeee aioo??oi?o oai?ia

? 2 Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Io?oe?ei? iiiiaioe:

— ae.i.i., noa?oee iaoeiaee ni?a?ia?oiee, Aii/a?iaa Ea?ena Na?a??aia,
caa?aeoaa/ eaai?aoi???th iaoiii?oieia?? Oa?e?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo caaaeueii? oa iaa?aeeeaaeii? o??o?a??.

— ae.i.i., i?ioani? ?aoaoi?eiaa Ieueaa Na?a??aia, caa?aeoaa/ eaoaae?ith
iaoieia?/ii? aiaoii?? Eoaainueeiai iaaee/iiai oi?aa?neoaoo.

I?ia?aeia onoaiiaa: ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII
Oe?a?ie, eaai?aoi??y iaoiii?oieia??, i. Ee?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 8 ea?oiy 1999 ?ieo i 13-30 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae. 64.600.01. i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith: 310022,
i. Oa?e?a, i?. Eai?ia, 4

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? OAeIO (310022,

i. Oa?e?a, i?. Eai?ia,4)

Aaoi?aoa?ao ?ic?neaii “ 6 ” aa?aciy 1999

O/aiee nae?aoa? niaoe?ae?ciaaii? ?aaee,

e.i.i., aeioeaio
I.I. Oaiueei

Caaaeueia oa?aeoa?enoeea ?iaioe.

AEOOAEUeI?NOUe I?IAEAIE: Ia no/aniiio aoai? ?icaeoeo iaaeeoeeie iaei??th
c aeooaeueieo i?iaeai ia?eiaoaeueii? iaoieia?? caeeoa?oueny
aioaiaoaeueia ioi?iia ieiaea, cieaeaiiy caoai?thaaiino? oa nia?oiino?
iiaiia?iaeaeaieo o iinoiaoaeueiiio ia??iae?.

Ca aeaieie AIC (1997) ia?eiaoaeueia iaoieia?y caeia? 4 i?noea na?aae
i?e/ei caaaeueii? nia?oiino? ianaeaiiy. ??aaiue aeeoy/i? nia?oiino? a
Oe?a?i? a 1997 ?ioe? aeinyaioa 13,5 ia 1000 ia?iaeaeaieo aeeaeie(I.A.
Aieaea, 1998), a ii i?noo Oa?eiao oeae iieaciee ua aeua ? neeaaea? 14,8
ia 1000 ia?iaeaeaieo aeeaeie. Ca inoaii? aeanyoe??//y na?aae ia?aeiieo
oai?ia aeeoy/iai a?eo caoai?thaai?noue na/iai? nenoaie ca?eueoeeanue o
2,5-3 ?ace, i?e/iio a?eueo?noue c ieo niinoa??aa?oueny a aeiee?i?/i?e
noaae?? ? eeoa?oueny iaae?aaiinoiaaieie (I.N. ?aiaoiaa, TH.A.
Aaeueoeuaa,1989).

Aeno?aaai?oaeuei? oai?iae iaoa??, oyaee? oneeaaeiaiiy aaa?oiino?,
aaaeeea? oaeoi?e iaaeieeoiueiai na?aaeiaeua iaaeaaii?e?iii aieeaathoue
ia oi?ioaaiiy e ?icaeoie on?o i?aai?a oa nenoai, o oiio /ene? e ie?ie.
Iaoyaeaiee ia?aa?a aaa?oiino? e iieia?a o iaoa??, iaoieia?/iee noai
ia??iaeo iiaiia?iaeaeaiino? iaee i?noea a 63% ae?oae, oai?eo ia
i??eiiao?eo, o 22% c i?ia?anoth/ith oi?iith aeiia?oeiiao?eoo (A.A.
Iaeiaaoeueea, 1996).

I?ci?e aanoic, oeoe?iaee ae?aaao ? oeio, o?ii?/i? oai?iae ie?ie iaoa??
aeineoue /anoi oneeaaeiththoue ia?aa?a aaa?oiino?, i?eaiaeyoue aei
?icaeoeo oaoi-ieaoeaioa?ii? iaaeinoaoiino?, iane?aeeii yei? ? o?ii?/ia
a?iien?y, a?iio?io?y ieiaea e iiaiia?iaeaeaiiai, ii?oiooieoe?iiaeueia
iac??e?noue, aeniea caoai?thaai?noue oa eaoaeuei?noue, ui a?aeia?aaea?
ianiaoeeo?/iee aieea oeacaieo iaoieia?/ieo noai?a iaoa?? ia ?icaeoie
ethaeeie a iiaeaeueoiio iioiaaiac?.

Ia aeoieo aeayeeo aeine?aeiee?a, ?nio? ca’ycie i?ae caoai?thaaiiyie
ie?ie iaoa?? e ieiaea (?.O. Aaa?eeia, 1985, I.I. Oaooiai,1987).
O?aaeaiiy ie?ie aaa?oii? iaoa?? i?e i?ciueiio aanoic? (IA), oeoe?iaiio
ae?aaao? (OeAe) ? oeio, o?ii?/iiio aeiia?oeiiao?eo? (OAI), ye?
niaoeeo?/ii aieeaathoue ia ie?ae, iiaea ni?eyoe aeieeiaiith ie?eiai?
iaoieia?? a iauaaee?a. Ca aeaieie e?oa?aoo?e aei oeueiai /ano ua iaia?
/?oeiai oyaeaiiy i?i ii?oiooieoe?iiaeueiee noai ie?ie ieiae?a, ui
ia?iaeeeeny a?ae iaoa??a, oai?eo ia o?ii?/iee aeiia?oeiiao?eo, oeoe?iaee
ae?aaao ? oeio; e?aua aea/aiee aieea aanoico ia aia??iaaiac ie?ie,
iaeiae aaoi?e i?eaiaeyoue noia?a/eea? aeai?: iaei? aeine?aeaeaiiy (I.I.
Oonoiaaeiaa, 1988) na?ae/aoue i?i cao?eieo aeic??aaiiy ie?ie ieiae?a;
ae?oa? (?.?.Aaaethe, TH.A.Oeeuee?aeaee, 1991) iia?aeiieythoue i?i
i?enei?aiee iao?iaaiac.

Iaaaeyea cia/aiiy aeey ia?aa?ao aaa?oiino? ? ye ne?ae ?aiiueiai
iioiaaiaco iathoue na?aaeiaeui? oaeoi?e. Iaeiei ?c aaaeeeaeo oaeoi??a,
ye? aieiae?thoue oa?aoiaaiieie aeanoeainoyie, ? ?ii?coth/a ?aae?aoe?y,
ui iaaecae/aeii aeooaeueii aeey iaoi? aea?aeaae a i?ney/i?iiaeeuenueeee
ia??iae. E?oa?aoo?i? aeai? i?i /anoioo oa no?oeoo?o a?iaeaeaieo aaae
?icaeoeo a oe?eiio, ?, iniaeeai ie?ie, noia?a/eea?: iaei? aaoi?e
aeacothoue ia i?aeaeuaiiy /anoioe a?iaeaeaieo aaae ?icaeoeo – A.I.
Ieeiaaiia n niaao., (1992); ae?oa? aeine?aeieee ia niinoa??aaee
oaiaeaioe?? uiaei i?aeaeuaiiy oeueiai iieacieea (A.?. Eacthe n niaao.,
1988).

Ona oea iaoiiaeth? cia/iee ?ioa?an uiaei aea/aiiy aia??iaaiaco ie?ie
ieiae?a a oiiaao iaoieia?? iaoa?? oa na?aaeiaeuieo aieea?a aeey
aeooa??a, iaiiaoaeia?a, iaae?ao??a oa ii?oieia?a o ca’yceo c iio?aaaie
oai?aoe/ii? ? i?aeoe/ii? iaaeeoeeie.

CA’ssCIE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE. Aeena?oaoe?y i?noeoue
o nia? o?aaiaio iaoeiai-aeine?aeii? ?iaioe, yea aeeiio?oueny a
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?, iiia? aea?aeaaii?
?a?no?aoe?? 019800026.

IAOA ? CAAeA*? AeINE?AeAEAIIss: iaoith i?iaaaeaiiai aeine?aeaeaiiy aoei
aea/aiiy ii?oiooieoe?iiaeueiiai noaio ie?ie ieiae?a a oiiaao
oneeaaeiaii? i?ci?i aanoicii, oeoe?iaei ae?aaaoii ? oeio e o?ii?/iei
aeiia?oeiiao?eoii aaa?oiino?.

Caaea/? aeine?aeaeaiiy:

1. I?iaanoe aiae?c ee?i?/ieo oa niaoe?aeueieo aeooa?nueeeo aeaieo ca
?noi??yie iieia?a c o?aoiaaiiyi eaai?aoi?ieo iieaciee?a o a?oi?
ii??aiyiiy oa iniiaieo ( i?ci?e aanoic, OeAe ? oeio, OAI).

2. I?iaanoe aiae?c aeaieo aooiin?e a?oi aea/aiiy (eiio?iey, IA, OeAe ?
oeio ? OAI).

3. I?iaanoe ii?oieia?/ia aeine?aeaeaiiy ie?ie ieiae?a eiio?ieueii? oa
iniiaieo a?oi (IA, OeAe ? oeio, OAI).

4. I?iaanoe a?noio?i?/ia aeine?aeaeaiiy ie?ie ieiae?a eiio?ieueii?
a?oie, i?e aanoic?, oeoe?iaiio ae?aaao? oa o?ii?/iiio aeiia?oeiiao?eo? a
iaoa??.

5. I?iaanoe ?ioiiii?oieia?/ia aeine?aeaeaiiy ie?ie ieiae?a eiio?ieueii?
oa iniiaieo a?oi (IA, OeAe ? oeio, OAI).

6. I?iaanoe ii?oiiao?e/i? aeine?aeaeaiiy ie?ie ieiae?a eiio?ieueii?
a?oie, i?e IA, OeAe ? oeio, OAI o iaoa??.

7. I?iaanoe noaoenoe/iee aiae?c /anoioe oa no?oeoo?e o?iaeaeaieo aaae
?icaeoeo i?aai?a na/iai? nenoaie ca o?e ia??iaee: aei- oa
i?ney/i?iiaeeuenueeiai i’yoe??//y oa ianooii? o?noue ?ie?a ca a?o?aieie
iaoa??aeaie oeaio?o ia?eiaoaeueii? iaoieia??, iaeanii? ee?i?/ii? e?ea?i?
oa i?nueei? aeeoy/i? e?ea?i? ?7 i. Oa?eiaa.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAO?A. Iane?aeeii eiiieaeniiai
ii?oieia?/iiai, a?noio?i?/iiai, ii?oiiao?e/iiai oa
?ioiioethi?anoeaioiiai aeine?aeaeaiiy ? ?acoeueoaoe, ye? na?ae/aoue i?i
aioo??oiueioo?iaia iioeiaeaeaiiy ie?ie ieiae?a, ui ia?iaeeeeny a?ae
iaoa??a c i?ci?i aanoicii, oeoe?iaei ae?aaaoii ? oeio oa o?ii?/iei
aeiia?oeiiao?eoii. Oe? iioeiaeaeaiiy iathoue ianiaoeeo?/iee oa?aeoa? oa
i?iyaeythoueny cieaeaiiyi a?aeiinii? iane ie?ie; niia?eueiaiiyi oaii?a
aeeoa?aioe?thaaiiy ie?eiai? oeaieie, i?iyaii /iai ? caa?aaeaiiy a?eueoi?
e?eueeino? ?yae?a iao?ii?a oa a?aeiinii? e?eueeino? aia??iiaeueieo
eeoai/e?a; ii?ooaiiyi aia??iaaiaco ie?ie o aeaeyae? ina?aaeeiaeo
aeenieac?e oa ina?aaeeiaeo aeiia?oeiiao?e c
i?ie?oa?aoeaii-o?a?iieanoe/ieie ci?iaie oa o?enaoe??th ?ioiieo
eiiieaen?a ia aeiia?oey?ieo aacaeueieo iaia?aiao, o iacaia?oi? noaeeiieo
eeoai/e?a oa ia aacaeueieo iaia?aiao a?oa??e ie?ie; a oaeiae
aeoeaaoe??th eieaaaiiooai?aiiy a ie?eao ieiae?a a?oi, ye? aea/aeeny.
Ae?aci?noue oeeo ci?i caeaaeeoue a?ae iaoieia?? iaoa??. I?e i?ciueiio
aanoic? a iaoa?? aeuaaeacai? iioeiaeaeaiiy ie?ie ieiae?a aoee iaeiaio
ae?aaeai?, aei neeaaeo ?ioiieo eiiieaen?a ooiaeeee eeoa Ig M oa
N3-o?aeoe?? eiiieaiaioo. I?e oeoe?iaiio ae?aaao? oe? ci?ie cono??/aeeny
/ano?oa oa aoee a?eueo ae?aaeai?, a eeoai/eao o neeaae? ?ioiieo
eiiieaen?a ia?aaaaeaee Ig A, G ? N3-o?aeoe?y eiiieaiaioo. E??i oiai, i?e
aeaeiiiainiaaiiio oeoe?iaiio ae?aaao? a iaoa?? a ieiaea niinoa??aaeanue
ina?aaeeiaa ?io?eueo?aoe?y ae?eiaaiii ai?oae?th ie?eiaeo eaiaeueoe?a.
I?e o?ii?/iiio aeiia?oeiiao?eo? a iaoa?? aeuaaeacai? ci?ie a ie?eao
ieiae?a aoee iaea?eueo ae?aaeai?, a a no?oeoo?? ?ioiieo eiiieaen?a —
naiee oe?ieee (o ii??aiyi? c aanoicii ? oeoe?iaei ae?aaaoii) niaeo?
?ioiiaeiaoe?i?a: Ig A, M, G, C3-o?aeoe?y eiiieaiaioo. O ae?oae an?o a?oi
iiaeeeaei iane?aeeii caoai?thaaiiy iiaea aooe iao?ineea?ic.

I?aiaoaeueia i?io?eaeoeea o?aaeaiue ieiaea i?e aanoicao, oeoe?iaiio
ae?aaao?, o?ii?/iiio aeiia?oeiiao?eo? aeicaieeoue caiia?aoe
iai?oanoaoe?? aeuaiacaaii? ie?eiai? iaoieia?? a iinoiaoaeueiiio ia??iae?
?icaeoeo.

I?iaaaeaia aeine?aeaeaiiy a?o?aiiai iaoa??aeo iieacaei, ui a ia?o? 5
?ie?a i?ney aaa??? ia *AAN (1986-1990) /anoioa oa no?oeoo?a a?iaeaeaieo
aaae ?icaeoeo i?aai?a na/iai? nenoaie ii Oa?e?anueeiio ?aa?iio ia iaaoee
nooo?aeo ci?i. O ianooii? 6 ?ie?a (1991-1996) aeyaeeany oaiaeaioe?y aei
c?inoaiiy aaniethoii? e?eueeino? oaeeo aiiiae?e, oi/ a?aeiinia ?o
e?euee?noue a??ia?aeii e ia c?inea. I?e aea/aii? no?oeoo?e aaae na/iai?
nenoaie i?eaa?oaei oaaao i?aeianaiiy ieoiii? aaae oeaieiieo aeenieac?e,
o oie /an ye e?euee?noue a?oaeo aiiiae?e na/iai? nenoaie caeeoeeany
i?aeoe/ii iaci?iiith.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAO?A. Io?eiai? aeai?
aeicaieyoue e?ea?yi-iaoieiaai aeeoa?aioe?thaaoe iaoieia?/i? ci?ie a
ie?eao ieiae?a, iiaiia?iaeaeaieo, ae?oae ?aiiueiai a?eo ca iayai?noth
iaoa?einueei? iaoieia??, iaiiaoieiaai a?aoiaoaaoe ooieoe?iiaeueiee noai
na/iai? nenoaie a oaeeo iiaiia?iaeaeaieo, iaae?ao?ai oa iao?ieiaai
aeae?eyoe a?oie ?eceeo ia aeyaeaiiy ie?eiai? iaoieia?? a oeeo ae?oae a
iiaeaeueoiio iioiaaiac?. ?acoeueoaoe aeine?aeaeaiiy aeei?enoiaothoueny a
iaa/aeueiiio i?ioean? eaoaae?e iaoieia?/ii? aiaoii?? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, o i?aeoe/i?e ?iaio?
iaoieiaiaiaoii?/iiai a?aeae?eaiiy Oa?e?anueei? iaeanii? ee?i?/ii?
e?ea?i?.

INIAENOEE AIANIE AeENA?OAIOA. Aaoi?ii naiino?eii c?a?aiee iaoa??ae,
i?iaaaeaii ii?oieia?/ia, a?noio?i?/ia, ?ioiiii?oieia?/ia oa
ii?oiiao?e/ia aeine?aeaeaiiy, iniaenoi i?iaaaeaii aiae?c a?o?aiiai
iaoa??aeo iaoieiaiaiaoii?/ieo a?aeae?ee?a OIEE, ia?eiaoaeueiiai oeaio?o
oa i?nueei? aeeoy/i? e?ea?i? ?7 i.Oa?eiaa ca 1981-1996 ??. Aaoi?ii
oaeiae i?iaaaeaia noaoenoe/ia ia?iaea iaoa??aeo, aiae?c oa ocaaaeueiaiiy
io?eiaieo ?acoeueoao?a, ye? aeicaieeee noi?ioethaaoe iaoeia? iieiaeaiiy
? c?iaeoe aeniiaee aeaii? ?iaioe.

AI?IAAOe?ss ?IAIOE. Iniiai? iieiaeaiiy aeena?oaoe?? aeeeaaeai?,
iaaiai?ai? oa noaaeai? ia OO? i?aeiaeani?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeueiua i?iaeaiu iaoieiae/aneie aiaoiiee”
(Oa?e?a-Iieoaaa-1993); ia ? ?in?enueeiio c’?cae? iaoieiaiaiaoii?a
(Iineaa — 1997); OO?? i?aeiaeani?e iaoeiai-i?aeoe/i?e eiioa?aioe??
”Aeooaeueiua i?iaeaie iaoieiaee a nia?aiaiiuo yeieiae/aneeo oneiaeyo”
(Oa?e?a-Noie-1998), a oaeiae ia can?aeaiiyo Oa?e?anueeiai iaoeiaiai
oiaa?einoaa iaoieiaiaiaoii?a (1995, 1996).

Ai?iaaoe?y ?iaioe i?iaaaeaia ia ni?eueiiio can?aeaii? eaoaae?
iaoieia?/ii? aiaoii??, a?noieia?? ? aia??ieia?? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, eaoaae?e iaoieia?/ii? aiaoii??
Oa?e?anueeiai ?inoeoooo oaeineiiaeaiiy e?ea??a, i?icaeoo? Oa?e?anueei?
iaeanii? ee?i?/ii? e?ea?i? oa Oa?e?anueeiai oeaio?o ia?eiaoaeueii?
iaoieia?? 14.05.1998 ?.

IOAE?EAOe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo ?ia?o,
o niaoe?ae?ciaaieo aeaeaiiyo – 4, o oiio /ene? 1 naiino?eia; o ca??ieeao
iaoeiaeo i?aoeue — 5 , o oiio /ene? naiino?eieo — 3.

NO?OEOO?A OA IANssA AeENA?OAOe??. Aeena?oaoe?y aeeeaaeaia ia 167
noi??ieao iaoeiiieno. Neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, 3
?icae?e?a aeanieo aeine?aeaeaiue, ?o iaaiai?aiiy, aeniiae?a ? nieneo
e?oa?aoo?e (163 aeaea?aea). ?iaioa ?ethno?iaaia 17 oaaeeoeyie (ianyaii
11 noi??iie) ? 46 iaethieaie (ianyaii 23 noi??iee).

INIIAIEE CI?NO ?IAIOE

IAOA??AE OA IAOIAeE AeINE?AeAEAIIss. Iaoa??aeii i?iaaaeaiiai
aeine?aeaeaiiy aoee ie?ee, acyo? a?ae 102 ieiae?a, ye? caaeioee a aioa-
? ?io?aiaoaeueiiio ia??iae? a oa?i?i aanoaoe?? 28-41 oeaeaeaiue. ?icoei
iiia?eeo ia?oaiia?iaeaeaieo oa caa?? iaoa??aeo i?iaiaeeany a i?icaeoo??
Oa?e?anueeiai oeaio?o ia?eiaoaeueii? iaoieia?? ca ia??iae 1991-1996 ??e.
Eiio?ieueio a?oio aeine?aeaeaiiy neeaee ie?ee 25 ieiae?a, ui ia?iaeeeeny
a?ae caei?iaeo iaoa??a, aea caaeioee ?io?aiaoaeueii a?ae aino?iai
ii?ooaiiy ioiiaeiii-ieaoeaioa?iiai e?iaiia?ao oa iieiaiai? o?aaie.

Aei ia?oi? aeine?aeii? a?oie aeeth/ai? ie?ee 31 ieiaea, ui ia?iaeeeeny
a?ae iaoa??a c i?ci?i aanoicii ?, ??, ??? nooiaiy oyaeeino?; o ae?oao –
ie?ee 26 ieiae?a a?ae iaoa??a, aaa?oi?noue yeeo ia?aa?aaea ia oii?
oeoe?iaiai ae?aaaoo ? oeio eaaeiai, na?aaeiueioyaeeiai oa oyaeeiai
nooiaiy. O?aoth a?oio aeine?aeaeaiiy neeaee ie?ee 20 ieiae?a, ui
ia?iaeeeeny a?ae iaoa??a, oai?eo ia o?ii?/iee aeiia?oeiiao?eo c
iao?ioe/iei, a?ia?oii?/iei eiiiiiaioii oa ci?oaii? oi?ie. Ieiaee an?o
a?oi caaeioee a?ae ano?en??, iaoiiaeaii? ii?ooaiiyi
ioiiaeiii-ieaoeaioa?iiai e?iaiia?ao aai iieiaiai? o?aaie.

Iae?ineii?/ii aeine?aeaeoaaee iaeaea? ie?ee (anueiai 204), o?aoiaoaaee
ciai?oi?e aeaeyae, oi?io, iano, eiinenoaioe?th i?aaia. Ia o?iioaeueiiio
?ic??c? ioe?ithaaee noai ei?eiai? oa iiceiai? ?a/iaeie, neeciaeo
iaieiiie ienie ? /aoa/ie, i?ae?aoiaoaaee e?euee?noue i??ai?aeie.

Aeey a?noieia?/iiai, a?noio?i?/iiai, ?ioiiii?oieia?/iiai oa
ii?oiiao?e/iiai aeine?aeaeaiiy c eiaeii? ie?ee aeaiia iicaeiaaei?ie
?ic??caie /a?ac aanue i?aai ae??caee ieanoeio oiaueiith 0,004 i, yeo
iio?i ?icae?eyee ia aea? ??ai? /anoeie. Iaoa??ae o?enoaaee a caaooa?iiio
10% aiaeyiiio ?ic/ei? iaeo?aeueiiai oi?iae?io. Oiaoi/ee i?iaiaeeeeny
/a?ac oeaei?ae?i-ia?ao?i. A?noieia?/i? c??ce oa?aoaaee aaiaoienee?iii oa
aic?iii, ooenae?iii ca Aaeoaa?oii ia aeyaeaiiy aeanoe/ieo aieie c
aeioa?aoaaiiyi i?e?iooeneiii ca iaoiaeii aai A?cii, aiee?iiaei nei?i ca
Iaei??. Ae?eiaai aeyaeyee a a?noieia?/ieo c??cao, caoa?aiaaieo ca
iaoiaeii Aanoa. Eiio?ieueia aeine?aeaeaiiy i?iaiaeeee O?E-?aaeoe??th c
eiio?ieai ai?eacith neeie.

?ioiiii?oieia?/ia aeine?aeaeaiiy aeeiiaii ia na??eieo c??cao ca
iai?yiei iaoiaeii Eoina c aeei?enoaiiyi ethi?i?noee?oth/eo nooeo
e?iey/eo ne?iaaoie i?ioe aeiaoe?i?a ethaeeie aei Ig A, M, G ?
N3-o?aeoe?? eiiieaiaioo (Aeaiooaa/ IAe?AI ?i. Aaiaea?, Iineaa). Eieaaaie
oeioaaeeny ca iai?yiei iaoiaeii Eoino c IEA aei eieaaai?a ?, ???, ?V oa
V oei?a.

Ii?oiiao?e/ia aeine?aeaeaiiy i?iaaaeaii ca?aeii c ?aeiiaiaeaoe?yie
A.A.Aaoaiaeeeiaa (1990); i?ae?aoiaoaaee aaniethoio e?euee?nue ?yae?a
iao?ii?a, iayai?noue aia??iiaeueieo eeoai/e?a, aecia/aany a?aeiiniee
ianya eeoai/e?a, eaiaeueoe?a, noaeei ? ?ioa?noeoe?th, ianya ie?eiaeo
eeoai/e?a V1, eainoe V2, a?aeiioaiiy V1:V2.

C iaoith aea/aiiy aieeao iane?aee?a aaa??? ia *AAN ia /anoioo oa
no?oeoo?o aaae ?icaeoeo na/iai? nenoaie aoa i?iaaaeaiee aiae?c 14523
i?ioieie?a ?icoeio ieiae?a, iiaiia?iaeaeaieo oa ae?oae a?eii aei 14
?ie?a. Ii?yae c oei i?iaaaeaiee aiae?c aeienie c ?noi??e aaa?oiino? oa
iieia?a; ?noi??e ?icaeoeo iiaiia?iaeaeaieo ? ae?oae ??ciiai a?eo ca
a?o?aaie ia?eiaoaeueiiai oeaio?o, i?icaeoo?e Oa?e?anueei? iaeanii?
ee?i?/ii? e?ea?i? oa i?nueei? aeeoy/i? e?ea?i? ? 7 i. Oa?eiaa ca
1981-1996 ?.?. I?e ciaeiinoa? c aeacaieie aeua aeieoiaioaie o?aoiaoaaee
noaoue, a?e aeeoeie, aiiiae?th ?icaeoeo na/iai? neoaie (?cieueiaai?,
iiiaeeii? oa nenoaii? aaaee).

*eneia? aeai? ia?iaeai? ca iaoiaeii aa??aoe?eii? noaoenoeee c
ia/eneaiiyi na?aaeiuei? a?eoiaoe/ii? (I), na?aaeiueieaaae?aoe/iiai
a?aeoeeaiiy (?), na?aaeiuei? iiieeee ??cieoe? (t), ?iia??iino? ??cieoe?
(?). ?iia??i?noue ??cieoe? i?ae aeaiia na?aaei?ie i?e iaeeo aea??eao
aecia/aee ca oaaeeoeath Nouethaeaioa c aeio?eiaiiyi oiiae (n1+n2-2). I?e
aecia/aii? nooiaiy a??ia?aeiino? aeiioneaeany oi/i?noue ?<0,05. AEANI? NIINOA?AAEAIIss OA ?O IAAIAI?AIIss. Eiiieaenia ii?oieia?/ia aeine?aeaeaiiy i?iaiaeeeinue o a?aeiia?aeiino? c aeuaiacaaieie a?oiaie (eiio?ieue, ii?oieia?/i? ci?ie a ie?eao ieiae?a, ye? ia?iaeeeenue a?ae iaoa??a, oai?eo ia i?ci?e aanoic, oeoe?iaee ae?aaao ? oeio, o?ii?/iee aeiia?oeiiao?eo). I?e iae?ineii?/iiio aeine?aeaeaii? a?aecia/aii cieaeaiiy a?aeiinii? iane ie?ie (%) a?aeiinii aei caaaeueii? iane o?ea ieiae?a o aeine?aeieo a?oiao a ii??aiyii? c eiio?ieai. Naia iaioa cia/aiiy aoei i?e OAI iaoa?? (0,72±0,02 % i?ioe 0,98±0,03% a eiio?ieuei?e a?oi?), o oie /an, eiee i?e i?ciueiio aanoic? oa OeAe oeae iieaciee aei??aithaaa a?aeiia?aeii 0,91±03% ? 0,95±0,03%. Ciaioaiiy a?aeiinii? iane ie?ie noi?oaiaeaeo?oueny niia?eueiaiiyi oaii?a aeeoa?aioe?thaaiiy ie?eiai? oeaieie, i?iyaii /iai ? caa?aaeaiiy a?eueoi? e?eueeino? ?yae?a iao?ii?a oa a?aeiinii? e?eueeino? aia??iiaeueieo eeoai/e?a. Niia?eueiaiiy aeic??aaiiy ie?eiai? oeaieie ieiae?a yne?aa?oa aoei o aeiaaeeao OAI o iaoa?? – o na?aaeiueiio aaniethoia e?euee?noue ?yae?a iao?ii?a neeaaeaea 11,7±0,5 (i?ioe 10,7±0,5 a eiio?ie?), a?aeiinia e?euee?noue aia??iiaeueieo eeoai/e?a – 11,8±0,4% (i?ioe 9,6±0,4%, ?<0,01); iacia/ii i?e i?ciueiio aanoic? – a?aeiia?aeii 11,6±0,3 oa 11,4±0,04 (?<0,01). I?e OeAe iaoa?? a ie?eao ieiae?a aaniethoia e?euee?noue ?yae?a iao?ii?a aoea oaeiae a?eueoith, i?ae o eiio?ieuei?e a?oi? (11,5±0,5); a?aeiinia e?euee?noue aia??iiaeueieo eeoai/e?a – ?iia??ii aeua, i?ae o eiio?ieuei?e a?oi? – 10,5±0,5%. I?e ii?oiiao?e/iiio aeine?aeaeaii? oaeiae aoea aecia/aia oaiaeaioe?y ui aei ciaioaiiy a?aeiiniiai ianyao eeoai/e?a, eaiaeueoe?a, na?aaei?o ianya?a noaeeiieo eeoai/e?a oa eainoe ia oii? ca?eueoaiiy a?aeiinieo ianya?a noaeei oa ?ioa?noeoe?th a aeine?aeieo a?oiao o ii??aiyii? c eiio?ieai, ui na?ae/eoue i?i cieaeaiiy oaii?a ?inoo ai?oae?aeueiiai eiiiiiaioo ie?ee. Oaeei /eiii, ca?eueoaiiy iane i?aaio a?aeaoaa?oueny ia?aaaaeii ca ?aooiie no?iiaeueii-noaeeiiiai eiiiiiaioo, ui na?ae/eoue i?i i?iyae a?iiene/iiai noaio ie?eiai? oeaieie a oiiaao iaoyaeaiiai ia?aa?ao aaa?oiino?. A?aeiii, ui i?ae aieeaii oyaeeeo oneeaaeiaiue aaa?oiino?, o?ii?/i?e niiaoe/i?e iaoieia?? iaoa?? a?aeaoaa?oueny ia o?eueee cao?eiaiiy aia??iaaiaco ie?ie, aea ? ii?ooaiiy eiai, yea noi?oaiaeaeo?oueny ?icaeoeii aeenieac?e, ui iienaii aaaaoueia aeine?aeieeaie (A.I. Eeaiaianueeee, 1989; A.A. Iaeiaaoeueea, O.A. ?iiaiiaa, 1988; A.?. E?aaoeiaa, A.?. Eacthe, 1975; Y.N. Na?aa?ia,1989; A.A. Eo?eei, I.I. Oonoiaaeiaa, 1985; B.S. Arant, 1987). Ii?ooaiiy aia??iaaiaco ie?ie niinoa??aaeinue o ieiae?a an?o aeine?aeieoeueeeo a?oi, e??i eiio?ieueii?, ? aoei o aeaeyae? ina?aaeeiai? aeenie?c??. O na?aaeiueiei?oeeaeuei?e cii? ciaoiaeeeeny ai?caei? neiie/aiiy o?nii i?eeyaath/eo iaeei aei ae?oaiai i?ei?oeaieo eeoai/e?a oa eaiaeueoe?a, ioi/ai? iacaio?iith aia??iiaeueiiai oeio. ?iiae? ina?aaeee aeenieanoe/ieo no?oeoo? niieo/aeenue ?c eeoai/eiaeie oa eaiaeueoeaaeie e?noaie, caeaa?eueoiai ciaoiaeeeenue o noaeainoey?i?e cii?. *anoioa aeenieac?e aoea ??ciith. O ieiae?a a?oie, ui ia?iaeeeeny a?ae iaoa??a c aanoicii, aiia cono??/aeany a 12,8% aeiaaee?a. O a?oi? ieiae?a a?ae iaoa??a c OeAe /anoioa aeenieac?e aoea aeua – 15,4%, a a a?oi? ieiae?a a?ae iaoa??a c OAI aeenieac?y cono??/aeany /ano?oa – o 20% niinoa?aaeaiue. O ? a?oi? niinoa?aaeaiue aeenieac?y ie?ie aoea o ieiae?a, iaoa?? yeeo no?aaeaeaee IA ??-??? no. oyaeeino? c aenieeie oeeo?aie a?oa??aeueiiai oeneo oa i?ioa?io???. O ?? oa ??? a?oiao niinoa?aaeaiue ii?ooaiiy aia??iaaiaco ie?ie aoei a ieiae?a, ui ia?iaeeeeny a?ae iaoa??a c aaaeeei ia?aa?aii iniiaiiai caoai?thaaiiy a niieo/aii? c i?ci?i aanoicii. Iiaeeeai, a?eueo iecueea /anoioa ie?eiaeo aeenieac?e o ieiae?a, ui ia?iaeeeeny a?ae iaoa??a c aanoicii, iiynith?oueny oei, ui iao?iiao?y aaa?oieo aeieea? i?ney 24-25 oeaei?a aanoaoe?? ? ni?ey? iaoiaaiiiio aieeao o a?eueo ei?ioeee /an, i?ae aeno?aaai?oaeuei? caoai?thaaiiy, ye? iaaaoeaii aieeaathoue ia ?icaeoie ieiaea, eiai i?aai?a ? nenoai c ia?oeo aei?a aaa?oiino?. Ua iaeiei i?iyaii ii?ooaiiai aia??iaaiaco ie?ie aoei ciaoiaeaeaiiy ina?aaeeiaeo aeiia?oeiiao?e c aeeno?io?/ieie oa i?ie?oa?aoeaii-o?a?iieanoe/ieie ci?iaie. O noaeeiieo eeoai/eao niinoa??aaeiny ?icoe?aiiy iacaia?oio ca ?aooiie i?ie?oa?aoe?? iacaia?aeueieo oa aiaeioae?aeueieo ee?oei c i?aeaeuaiei ooai?aiiyi iaia?aiiiiae?aii? ?a/iaeie, ui aea? yne?aao O?E-iiceoeaio ?aaeoe?th; aacaeuei? iaia?aie eai?ey??a ia??aiii??ii iioiauai?, aeaioeiioo?i?. Ie?ai? iaoe? eeoai/e?a neea?iciaai?; aeaye? eeoai/ee iaee aeaeyae aeaioeiianoieo ooai?aiue. *anoioa ina?aaeeiaeo aeiia?oeiiao?e aoea ??ciith a ieiae?a aeine?aeieo a?oi. Oae, o ia?o?e a?oi? aiia neeaea 9,7% (o eiio?ieueieo niinoa?aaeaiiyo ?o ia aoei); o ae?oa?e – 22,2% ? a o?ao?e – 30%. Iaoa?? oeeo ae?oae no?aaeaeaee a?aeiia?aeii oyaeeeie oi?iaie aanoico, oeoe?iaiai ae?aaaoo oa o?ii?/iiai aeiia?oeiiao?eoo. I?e a?noio?i?/iiio aeine?aeaeaii? a ie?eao ieiae?a a?ae iaoa??a c oyaeeei ia?aa?aii oeoe?iaiai ae?aaaoo a?aei?/aeanue ina?aaeeiaa ?io?eueo?aoe?y ae?eiaaiii ai?oae?th ie?eiaeo eaiaeueoe?a (iaoiae Aanoa, eiio?ieue – O?E – ?aaeoe?y). ?acoeueoaoe ?ioiiii?oieia?/iiai aeine?aeaeaiiy ie?ie ieiae?a, ui aea/aeenue, aoee ??cieie. O ieiae?a eiio?ieueii? a?oie ?ioiieiiieaene a ie?eao ia ooai?thaaeenue. O ieiae?a ? a?oie noa??oa 36 oeaei?a aanoaoe?? aacaeuei? iaia?aie eai?ey??a noaeeiieo eeoai/e?a aeaaaee yne?aaa e?i?eia oa a?aioey?ia na?/aiiy; aei neeaaeo ?ioiieo eiiieaen?a aoiaeeee Ig M ? N3-o?aeoe?y eiiieaiaioo. Ca aeaieie e?oa?aoo?e (A.A. Na?ia, 1983) i?i aeoeaaoe?th nenoaie N3 eiiieaiaioo i?e iaia?aiicii-i?ie?oa?aoeaiiio aeiia?oeiiao?eo? iiaeia ia?aaeaa/aoe, ui o ieiae?a a?ae iaoa??a c aanoicii oaea aioo??oiueioo?iaii oi?iothoueny ii?oiaaiaoe/i? iaoai?cie, ?aae?caoe?y yeeo o iinoiaoaeueiiio ia??iae? ia iiaea aooe aeiyoeii iiaeeeaino? oi?ioaaiiy aeiia?oeiiao?eoo. I?e eaae?e oi?i? oeoe?iaiai ae?aaaoo a iaoa?? a ie?eao ieiaea iaei i?noea ooai?aiiy Ig G a noaaiaeioae?aeueieo a?aeae?eao a?oa??ie oa a aacaeueieo iaia?aiao eeoai/e?a. O?aoiaoth/e, ui ?c an?o ?ioiiaeiaoe?i?a iaoa?? aei ie?ie ieiaea o?ainieaoeaioa?ii i?iieea? eeoa Ig G, a oaeiae oa, ui a?eueo?noue ie?eiaeo aioeo?e ? Ig G (I.ss. O?oiiaa, 1977; A.Goldstone et al., 1979; D.R. Branch, 1979), iiaeia i?eionoeoe ia?aaaaeii iaoa?einueea iioiaeaeaiiy oeueiai ?ioiiaeiaoe?io, yeee ciaoiaeyoue o noaeeiao oa eeoai/eao ie?ie ieiaea. I?e oyaeeeo oi?iao OeAe o iaoa?? a ie?eao ieiaea ciaoiaeyoue a?eueo ianeai? a?aeeeaaeaiiy Ig G, ia?aaaaeii e?i?eiiai neeaaeo, ui iiaea na?ae/eoe i?i ii?ooaiiy a?ineioaco eiiiiiaio?a aacaeueieo iaia?ai ? iacaia?th ? iiaea aooe iaoiiaeaii iai?iii-iaoaaie?/ieie ?iceaaeaie, ye? oa?aeoa?i? oai?ei ia OeAe (Y.N. Naaa?a?ia, A.A. Iiiiia?ueia, 1988). E??i oiai, i?e oyaeeeo oi?iao OeAe ? oeio iaoa??, i/aaeaeii, aiane?aeie i?e?iaia?iiao?? a ie?eao ieiaea, ye i?iyae ae?aaaoe/ii? oaoiiao??, ?icaeaathoueny ?ioiiii?oieia?/i? ci?ie, iiae?ai? aia?ii?ie?oa?aoeai?e oi?i? aeiia?oeiiao?eoo, oiaoi Ig A-oi?i? (A.I. Aa?oaanueeee, A.A. Aa -naiia, 1990). I?e ?ioiiii?oieia?/iiio aeine?aeaeaii? ie?ie ieiae?a a?ae iaoa??a c a?ia?oii?/iith aai ci?oaiith oi?iith o?ii?/iiai aeiia?oeiiao?eoo, oneeaaeiaiiai i?ci?i aanoicii ia aacaeueieo iaia?aiao aeiia?oe, o iacaia?oi? noaeeiieo eeoai/e?a oa a aacaeueieo iaia?aiao a?oa??e ie?ie aoa ciaeaeaiee naiee oe?ieee niaeo? ?ioiiaeiaoe?i?a – IgA,M,G oa N3-o?aeoe?y eiiieaiaioo, ui na?ae/eoue i?i oyaeea aioo??oiueioo?iaia iioeiaeaeaiiy ie?ie ? iiaea a iiaeaeueoiio iioiaaiac? ni?eyoe ?icaeoeo ??cieo oi?i aeiia?oeiiao?eoo. I?e ?ioiiii?oieia?/iiio aea/aii? ?iciiae?eo oei?a eieaaaio a ie?eao ieiae?a eiio?ieueii? a?oie ciaeaeaii, ui ?ioa?noeoe?aeueiee eieaaai ?, ?? oaV oei?a ooai?th?oueny a eainoe? eeoai/e?a, ia?eooaoey?ieo aieieiao oa ?ao?eoey?i?e oeaiei? ei?eiai? oa iiceiai? ?a/iaeie o aeaeyae? iacia/ii? ?ioiioethi?anoeaioe??, i?e/iio ia?aaaaeaa eieaaai ??? oeio. A aiaeioae?? e?ioeaaeo a?eie ie?eiaeo a?oa??e ciaoiaeeany eieaaai IV oa V oei?a. O aacaeueieo iaia?aiao noaeeiieo eeoai/e?a aoee o?eueee ne?aee eieaaai?a IV oa V oei?a. O aeinooii?e e?oa?aoo?? ie ia ciaeoee aeaieo i?i ?iciiae?e oei?a eieaaaio a ie?eao ieiae?a oa iiaiia?iaeaeaieo. O ca’yceo c oeei ie aaaaea?ii i?aaii??iei aeei?enooaaoe iaea?aeai? iaie aeai? uiaei ?iciiae?eo eieaaai?a ??cieo oei?a o ie?eao ieiae?a a?oie ii??aiyiiy a yeino? eiio?ieth i?e aea/aii? oeueiai iieacieea a ieiae?a, ui ia?iaeeeeny a?ae iaoa??a c aanoicii, oeoe?iaei ae?aaaoii ? o?ii?/iei aeiia?oeiiao?eoii. Ia a?aei?io a?ae eiio?ieth a ieiae?a o a?oi? a?ae iaoa??a c i?ci?i aanoicii, a oaeiae oai?eie ia OAI a ie?eao niinoa??aaeinue iineeaiiy ?ioaineaiino? na?/aiiy o aeiaaeeao, aea a?noieia?/i? c??ce aoee ia?iaeai? aioene?iaaoeith aei eieaaaio ? ? ??? oeio, oiae? ye V oei eieaaaio aoa iiae?aiei eiio?ieth. O aacaeueieo iaia?aiao eeoai/e?a oa e?ioeaaeo a?eeao ie?eiai? a?oa??? /?oe?oa, i?ae a eiio?ie?, aeyaeyany eieaaai IV oa V oei?a. Ia i?aenoaa? aeuaaeeeaaeaiiai iiaeia i?eeoe aei aeniiaeo i?i aeayea iineeaiiy eieaaaiiooai?aiiy a ie?eao ieiae?a a?ae iaoa??a c i?ci?i aanoicii oa OAI. Iaiaaia, iineeaia eieaaaiiooai?thaaiiy ? iane?aeeii a?iien?? ieiaea, ye ii/aoeiaiai i?ioeano iao?ineea?ico. I?e oyaee?e oi?i? oeoe?iaiai ae?aaaoo a iaoa?? a no?ii? ie?ie ieiae?a na?/aiiy eieaaaio ?, ??? ? IV oei?a aoei a?eueo ?ioaineaiei, i?ae o eiio?ieuei?e a?oi?. O aacaeuei?e iaia?ai? noaeeiieo eeoai/e?a oa i?aeeaiaeueoeaaeo eai?ey?ao a?eueo yne?aaith aoea e?i?eia ?ioiioethi?anoeaioe?y eieaaaio IV oeio ? neaaea a?aioey?ia eieaaaio V oeio. Ona oea na?ae/eoue i?i aeoeaia eieaaaiiooai?aiiy a ie?eao ieiae?a, ui ia?iaeeeeny a?ae iaoa??a oai?eo ia oeoe?iaee ae?aaao, ui, iaiaaia, ? iaeiei ?c i?iya?a ae?aaaoe/ii? i?e?iaia?iiao?? ye iane?aeeo a?iien??. O iiaeaeueoiio iioiaaiac? oea iiaea noaoe iaeiei ?c ii?oieia?/ieo eaioetha?a o ?icaeoeo iao?ineea?ico. Iaaaaeai? aeai? na?ae/aoue i?i oa, ui i?e oyaee?e oi?i? aanoico a ie?eao ieiae?a niinoa??aa?oueny niia?eueiaiiy iao?iaaiaco a niieo/aii? c iii??iiae?aaeaieie aeenieanoe/ieie i?ioeanaie e iciaeaie Ig M-caeaaeieie aeiia?oeiiao?yie. O ie?eao ieiae?a a?ae iaoa??a, oai?eo ia oeoe?iaee ae?aaao ? oeio i?aaaeththoue aeenieac??, aeeno?io?/i? oa i?ie?o??aoeaii-o?a?iieanoe/i? ci?ie c a?aeeeaaeaiiyi a ?ioiieo eiiieaenao ia?aaaaeii Ig A oa G. Aeineoue /anoi niinoa??aa?oueny cao?eiea aeic??aaiiy noaeeiieo eeoai/e?a. O?ii?/iee aeiia?oeiiao?eo iaoa?? iani?yoeeai aieeaa? ia aia??iaaiac oa ii?oiooieoe?iiaeueiee noai ie?ie ieiaea. Oae, o ieiae?a, ui ia?iaeeeeny a?ae iaoa??a, oai?eo ia OAI (a?ia?oii?/ia oa ci?oaia oi?ia), oneeaaeiaiei i?ci?i aanoicii, ciaeaeaii, c iaeiiai aieo, niia?eueiaiiy iao?iaaiaco, c ae?oaiai - ae?aaeai? ?ioii? ?aaeoe?? o aeaeyae? a?aeeeaaeaiiy ?ioiieo eiiieaen?a, o neeaae? yeeo ciaoiaeyoueny Ig A, M, G oa N3-o?aeoe?y eiiieaiaioo. Aacoiiaii, on? ae?oe, ui ia?iaeeeeny ia oii? oyaeeeo oi?i aanoico, o?ii?/iiai aeiia?oeiiao?eoo oa oeoe?iaiai ae?aaaoo ? oeio iiaeii? aooe a?aeianai? aei a?oie aenieiai ?eceeo a aniaeo? ?icaeoeo a ieo o iiaeaeueoiio iioiaaiac? ??cieo oi?i aeiia?oeiiao?e. O oie aea /an i?iaaaeaiiy no/anieo aaeaeaaoieo i?io?eaeoe/ieo caoiae?a o a?oiao iiaiia?iaeaeaieo c i?aeaeuaiei ?eceeii aeicaieeoue caiia?aoe ?icaeoie iai?oanoiiai caoai?thaaiiy. O oeueiio ieai? ne?ae ia caaoaaoe, ui ie?ee ? i?aaiaie c aenieeie aaeaioaoe?eii-eiiiainaoi?ieie iiaeeeainoyie (I.N. Na?eenia, 1987). I?e aeine?aeaeaii? a?o?aiiai iaoa??aeo (ca ? ia??iae aoei ianoaaeaii 4376 i?ioieie?a ?icoeio; ca ?? – 4472 ? ??? – 5684) aoei aeyaeaii, ui a aei/i?iiaeeuenueeiio ia?eiae? a?iaeaeaie aaaee ?icaeoeo i?aai?a na/iai? nenoaie iaee i?noea a 200 aeiaaeeao (4,71±0,38%), o iino/a?iiaeeueneea i’youe ?ie?a – aiie aeyaeyeenue o 222 niinoa?aaeaiiyo (4,99±0,34%) ? a ianooii? o?noue ?ie?a – o 314 aeiaaeeao (5,53±0,22%). *ano?oa a?iaeaeaie aaaee aoiaeeee aei neeaaeo neiae?ii?a iiiaeeiieo o?iaeaeaieo aaae ?icaeoeo – 123 niinoa?aaeaiiy (60,0±0,97%) o ia?oee ia??iae, 149 (66,2±0,98%, ?<0,001) o ae?oaee ? 216 (67,4±0,89%) o o?ao?e. ?cieueiaai? aaaee i?aai?a na/iai? nenoaie cono??/aeeny a?aeiia?aeii a 43 (21,0±0,44%), 48 (21,3±1,02%) oa 66 (20,7±0,94%) aeiaaeeao. Iaeiaio iioe?aieie aoee nenoaii? aaaee: 34 niinoa?aaeaiiy (19,0±1,46%) a ia?oa i’yoe??//y, 25 (12,6±0,52%, ?<0,01) – o ae?oaa ? 32 (11,4±0,69%, ?<0,01) o o?aoueiio ia??iae?. Ca no?oeoo?ith a?iaeaeaieo aaae na/iai? nenoaie iniiaia i?noea iin?aeaee oeaieii? aeenieac?? ie?ie, ye? o 1981-1985 ??. cono??/aeenue o 71 niinoa?aaeaiiyo (34,7±1,1%), o 1986-1990 ??. ?o /enei neeaei 77 (34,2±1,7%), o 1991-1996 – 126 (39,3±1,2%, ?<0,05). Iano?oeoeai? aiiiae?? na/iaiae?a iaee i?noea a 41 (19,9±0,7%), 43 (18,9±1,2%) oa 65 (19,4±1,47%) aeiaaeeao a?aeiia?aeii, a?iiieac?y iaei??? /e iaio ie?ie o 30 (14,7±0,4%), 40 (17,8±0,7%, ?<0,01) oa 51 (16,1±0,9%, ?<0,05) aeiaaeeo. Iie?e?noic ie?ie aeyaeaii a 25 (12,2%) niinoa?aaeaiiyo o ? ia??iae, o 18 (7,9±0i ,8%) oa o 38 (11,9±0,9%) o ?? ? ??? a?aeiia?aeii; i?aeeiaiiiae?aio ie?eo - o 18 (8,8±0,6%), 16 (7,1±0,2%) oa 27 (10,7±0,4%) ae?oae; iaeii- /e aeainoi?iiith a?ai?th - o 22 (10,7±0,4%), 21 (9,4±0,4%) oa 32 (10,1±0,6%) a?aeiia?aeii; aaaiac?th na/iaiai i?oo?a oa na/iaiae?a - o 23 (11,1±0,9%), 24 (10,7±0,3%) oa 35 (10,9±0,7%) niinoa?aaeaiiyo. ?io? a?iaeaeai? aaaee i?aai?a na/iai? nenoaie cono??/aeeny cia/ii ??aeoa e ia ia?aaeuoaaee 1-2% i?ioyaii on?o 3 ia??iae?a. Iae/ano?oa aiiiae?? na/iai? nenoaie niieo/aeeny c aaaeaie oeaio?aeueii? ia?aiai? nenoaie (o I - 29,8±1,1%, o II - 33,6±1,3%, o III – 34,8±1,6%), iii?ii-?ooiaiai aia?aoo (a?aeiia?aeii 34,4±1,3%, 32,1±1,5%, 33,9±1,8%) oa iaee//y (9,9±1,8%, 30,2±1,1%, 29,4±0,91%). I?iaaaeaia aeine?aeaeaiiy iieacaei, ui a ia?o? 5 ?ie?a i?ney aaa??? ia *AAN (1986-1990) /anoioa oa no?oeoo?a a?iaeaeaieo aaae ?icaeoeo i?aai?a na/iai? nenoaie ii Oa?e?anueeiio ?aa?iio ia iaaoee nooo?aeo ci?i. O ianooii? 6 ?ie?a (1991-1996) aeyaeeanue oaiaeaioe?y aei c?inoaiiy aaniethoii? e?eueeino? oaeeo aiiiae?e, oi/ a?aeiinia ?o e?euee?noue a??ia?aeii e ia ca?eueoeeany. I?e aea/aii? no?oeoo?e a?iaeaeaieo aiiiae?e i?eaa?oaei oaaao i?aeianaiiy ieoiii? aaae oeaieiieo aeenieac?e ie?ie. Ii?yae ?c oeei, e?euee?noue a?oaeo aiiiae?e na/iai? nenoaie caeeoa?oueny i?aeoe/ii iaci?iiith. AENIIAEE: 1. Ii?oieia?/i? ci?ie a ie?eao ieiae?a i?e i?ciueiio aanoic?, oeoe?iaiio ae?aaao? ? oeio, o?ii?/iiio aeiia?oeiiao?eo? a iaoa?? niinoa??aathoueny i?e oyaeeiio nooiai? iaoieia?/iiai i?ioeano, iathoue ianiaoeeo?/iee oa?aeoa? ? i?iyaeththoueny cieaeaiiyi a?aeiinii? iane ie?ie; niia?eueiaiiyi oaii?a aeeoa?aioe?thaaiiy ie?eiai? oeaieie, i?iyaii /iai ? caa?aaeaiiy a?eueoi? e?eueeino? ?yae?a iao?ii?a oa a?aeiinii? e?eueeino? aia??iiaeueieo eeoai/e?a; ii?ooaiiyi aia??iaaiaco ie?ie o aeaeyae? ina?aaeeiaeo aeenieac?e oa ina?aaeeiaeo aeiia?oeiiao?e c i?ie?oa?aoeaii-o?a?iieanoe/ieie ci?iaie oa o?enaoe??th ?ioiieo eiiieaen?a ia aeiia?oey?ieo aacaeueieo iaia?aiao, o iacaia?oi? noaeeiieo eeoai/e?a oa ia aacaeueieo iaia?aiao a?oa??e ie?ie; a oaeiae aeoeaaoe??th eieaaaiiooai?aiiy a ie?eao ieiae?a. Niaoeeo?/i?noue iioeiaeaeaiue ie?ie ieiae?a i?iyaey?oueny neeaaeii ?ioiieo eiiieaen?a, ye?e caeaaeeoue a?ae oa?aeoa?a iaoieia?? iaoa??. 2. I?e i?ciueiio aanoic? a iaoa?? a ie?eao ieiae?a niinoa??aathoueny iii??i? ci?ie (o ii??aiyii? c OeAe ? OAI), ui i?iyaeththoueny cieaeaiiyi a?aeiinii? iane ie?ie (0,91±0,3% i?ioe 0,98±0,03% o eiio?ie?), niia?eueiaiiyi iao?iaaiaco (aaniethoia e?euee?noue ?yae?a iao?ii?a 11,6±0,3, o eiio?ie? – 10,7±0,5; a?aeiinia e?euee?noue aia??iiaeueieo eeoai/e?a 11,4±0,04%, o eiio?ie? – 9,6±0,4%) a niieo/aii? c aeenieanoe/ieie i?ioeanaie (12,8%) ? ina?aaeeiaeie aeiia?oeiiao?yie (9,7%) c a?aeeeaaeaiiyi IgI ? N3-o?aeoe?? eiiieaiaioo ia oii? iacia/iiai iineeaiiy eieaaaiiooai?aiiy. 3. I?e oeoe?iaiio ae?aaao? ? oeio a iaoa?? a ie?eao ieiae?a ii?oieia?/i? ci?ie a?eueo ae?aaeai? (a ii??aiyii? c aanoicii), ui i?iyaeth?oueny cao?eieith iao?iaaiaco (e?euee?noue ?yae?a iao?ii?a 11,5±0,5, a?aeiinia e?euee?noue aia??iiaeueieo eeoai/e?a 10,5±0,5%), aeenieanoe/ieie i?ioeanaie (15,4%), i?ie?oa?aoeaii-o?a?iieanoe/ieie ci?iaie eeoai/e?a (22,2%) c a?aeeeaaeaiiyi a ?ioiieo eiiieaenao Ig A, G ? N3- o?aeoe?? eiiieaiaioo ia oii? aeoeaiiai eieaaaiiooai?aiiy, a oaeiae ina?aaeeiaith ?io?eueo?aoe??th ae?eiaaiii ie?eiaeo eaiaeueoe?a. 4. I?e o?ii?/iiio aeiia?oeiiao?eo? a iaoa?? a ie?eao ieiaea i?aaaeththoue iciaee ??ceeo ii?ooaiue ii?oiooieoe?iiaeueiiai noaio ie?ie: a?aeiinia iana ie?ie neeaea 0,72%, e?euee?noue ?yae?a iao?ii?a 11,7±0,5, a?aeiinia e?euee?noue aia??iiaeueieo eeoai/e?a 11,8±0,4%, ina?aaeeia? aeenieac?? cono??/aeenue o 20% aeiaaee?a, i?ie?oa?aoeaii-o?a?iieanoe/i? aeiia?oeiiao?? c ae?aaeaieie ?ioiieie ?aaeoe?yie o aeaeyae? a?aeeeaaeaiiy ia aacaeueieo iaia?aiao ?ioiieo eiiieaen?a, aei neeaaeo yeeo aoiaeyoue Ig A, M, G ? N3-o?aeoe?y eiiieaiaioo iaee i?noea a 30%; iaeiae i?ioeane eieaaaiiooai?aiiy aoee ae?aaeai? iii??ii. 5. Ciaeaeai? ii?ooaiiy aia??iaaiaco ie?ie ieiae?a a?ae iaoa??a c IA, OeAe ? oeio, OAI a iiaeaeueoiio iioiaaiac? iiaeoo ni?eyoe aeieeiaiith ie?eiai? iaoieia??, oiio oe? ae?oe iio?aaothoue nai?/aniiai i?io?eaeoe/iiai iaaeyaeo c aieo aeooa??a-a?iaeieia?a, iaiiaoieia?a oa iaae?ao??a. 6. Aiae?c /anoioe oa no?oeoo?e a?iaeaeaieo aaae ?icaeoeo na/iai? nenoaie ca ia??iae c 1981 ii 1996 ??. ii Oa?e?anueeiio ?aa?iio ia aeyaea ?noioieo ci?i oeeo iieaciee?a o ia?o? i’youe ?ie?a i?ney aaa??? ia *AAN, o ianooii? o?noue ?ie?a a?aecia/a?oueny oaiaeaioe?y aei c?inoaiiy aaniethoii? e?eueeino? OA? INN, ia?aaaaeii ca ?aooiie oeaieiieo aeenieac?e ie?ie. 7. Ii?ooaiiy ii?oiaaiaco ie?ie ieiae?a ia iiaeooue aooe i?yii iaoiiaeai? aieeaii iane?aee?a aaa??? ia *AAN, a caeaaeaoue a?ae oyaeeino? ia?aa?ao iaoa?einueei? iaoieia??, iaeiae ia iiaeia aeeeth/eoe, ui ia?aa?a caoai?thaaiiy iaoa?? iiaea oneeaaeithaaoeny i?ae ae??th iani?eyoeeaeo oaeoi??a ciai?oiueiai na?aaeiaeua. I?AEOE*I? ?AEIIAIAeAOe??. 1. E?ea?yi - iaoieiaai ne?ae o?aoiaoaaoe aeyaeaie ci?ie a ie?eao ieiae?a ? iiaiia?iaeaeaieo a?ae iaoa??a c i?ci?i aanoicii, oeoe?iaei ae?aaaoii ? oeio oa o?ii?/iei aeiia?oeiiao?eoii ? ?acoe?ithaaoe ?o ye i?iyae niaoeeo?/ieo iao?iiao?e, iaoiiaeaieo iaoieia?/iei noaiii iaoa??. 2. I?io?eaeoeea aeooa?aie - a?iaeieiaaie oa iaiiaoieiaaie a?aaeaiue ieiaea a aioaiaoaeueiiio ia??iae? oa iiaiia?iaeaeaiiai a ?aiueiio iaiiaoaeueiiio ia??iae? i?e aanoic?, oeoe?iaiio ae?aaao?, o?ii?/iiio aeiia?oeiiao?eo? a iaoa?? aeicaieeoue caiia?aoe ?icaeoeo ie?eiai? iaoieia?? a iinoiaoaeueiiio ia??iae? ?icaeoeo. 3. Ae?oe, iaoa?? yeeo i?ae /an aaa?oiino? no?aaeaeaee ia oyaee? oi?ie i?ciueiai aanoico, oeoe?iaiai ae?aaaoo oa o?ii?/iiai aeiia?oeiiao?eoo, iaae?ao?aie oa iao?ieiaaie iiaeii? aooe a?aeianai? aei a?oie ?eceeo uiaei iai?oanoaoe?? ie?eiai? iaoieia?? a iiaeaeueoiio iioiaaiac?. NIENIE IOAE?EAOe?E. 1. Iaoiiaa I.A. Iniaaiiinoe ii?oiooieoeeiiaeueiiai ninoiyiey ii/ae iioiinoaa i?e iicaeiai aanoica aa?aiaiiuo o iaoa?e // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – Iieoaaa – Oa?ueeia. – 1998. - ? 8. – N. 95-103. 2. sseiaoeiaa A.O., Aoaeia-Aaeoeee A.E., Ni?ieeia E.A., Ia?eianeee A.Ae., Iiaeue/aiei I.A., Iaoiiaa I.A., Aa?aei A.A. Iaoiii?oieiae/aneia iainiiaaiea ia?eiaoaeueiuo oaeoi?ia ?enea ?acaeoey iaoieiaee // A?a/aaiay i?aeoeea. – Oa?ueeia. –1998. - ? 5. – N. 4-7. 3. sseiaoeiaa A.O., Iaoiiaa I.A. Aiae?c /anoino? oa no?oeoo?e o?iaeaeaieo aaae ?icaeoeo i?aai?a na/iaeae?eueii? nenoaie o iino/i?iiaeeuenueeee ia??iae (ii Oa?e?anueeiio ?aa?iio) // Oe?a?inueeee ?aae?ieia?/iee aeo?iae. – Oa?ueeia. – 1998. – Aei.3. - ? 3. – N. 347-348. 4. sseiaoeiaa A.O., Ni?ieeia E.A., Iaoiiaa I.A. Iaoiii?oieiaey ii/ae ieiaeia io iaoa?ae, no?aaeathueo iicaeiei aanoicii, naoa?iui aeeaaaoii I oeia e o?iie/aneei aeiia?oeiiao?eoii // A?oea iaoieiaee. – Iineaa. – 1998. -? 6, N. 33-36. 5. Iaoiiaa I.A. Ii?oiooieoeeiiaeueiua iniaaiiinoe ii/ae ieiaeia io iaoa?ae n naoa?iui aeeaaaoii // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu. Na. noaoae – Aeiiaoee. – 1997. –N. 130-133. 6. Iaoiiaa I.A. Aeeyiea iicaeiaai aanoica aa?aiaiiuo ia yia?eiaaiac ii/ae ieiaea // Iaaeeoeeia naaiaeiy e caao?a. Ia?eiaee/. na. ?aaio iieiaeuo o/aiuo e niaoeeaeenoia. – 1997. – Aui. 2. – N. 18-19. 7. Iaoiiaa I.A. Aeeyiea o?iie/aneiai aeiia?oeiiao?eoa iaoa?e ia yia?eiaaiac ii/ae iioiinoaa // Nia?aiaiiua ooiaeaiaioaeueiua e i?eeeaaeiua i?iaeaiu eeeieee aioo?aiieo aieaciae. Oac. aeiee. ?ani. iao/.-i?aeo. eiio. iieiaeuo o/aiuo e niaoeeaeenoia.–1997.- N. 74. 8. Iaoiiaa I.A., Neia/aaa A.A. Oa?aeoa?enoeea a?iaeaeaiiuo ii?ieia ?acaeoey ii/aaie nenoaiu a nayce n iineaaenoaeyie aaa?ee ia *a?iiaueueneie AYN // Ia?eiaoaeueiay iaoieiaey e /anoiua aii?inu iaoieiae/aneie aiaoiiee.- Na. iao/ o?oaeia. – 1993. – N. 32-34. 9. sseiaoeiaa A.O., Aoaeia-Aaeoeee A.E.,Ni?ieeia E.A., Iaoiiaa I.A. Aeiiioaiiue ieiae i?e iaoa?eineie aeiiaeeiaiee: ii?oiooieoeeiiaeueiia ninoiyiea yiaeie?eiiie nenoaiu e ioaeaeueiuo i?aaiia ae?oaeo nenoai // Iao. I eiia?anna ii?oieiaia Aaea?one. – Ieine. –1996. – O. 2. – N. 105-106. AIIOAOe?ss. Iaoiiaa I.A. Ii?oiooieoe?iiaeueiee noai ie?ie ieiae?a a?ae iaoa??a c i?ci?i aanoicii, oeoe?iaei ae?aaaoii ? oeio oa o?ii?/iei aeiia?oeiiao?eoii a oiiaao Oa?e?anueeiai ?aa?iio. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.02 – iaoieia?/ia aiaoii?y.– Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?th i?enay/aii ieoaiiyi ii?oiaaiaco ie?ie ieiae?a a oiiaao oneeaaeiaiiai i?ci?i aanoicii, oeoe?iaei ae?aaaoii ? oeio, o?ii?/iei aeiia?oeiiao?eoii ia?aa?ao aaa?oiino? a iaoa??a. Aeyaeaii iciaee cao?eiee aeic??aaiiy ? ii?ooaiiy aeeoa?aioe?thaaiiy ie?eiai? oeaieie; ina?aaeeia? aeenoi?io?/i?, i?ie?oa?aoeai? oa o?a?iieanoe/i? ci?ie eeoai/e?a c ooai?aiiyi ?ioiieo eiiieaen?a. Ciaeaeai? iciaee aeoeaaoe?? eieaaaiiooai?aiiy. Iaea?aeai? ?acoeueoaoe noaoenoe/iiai aeine?aeaeaiiy a?iaeaeaieo aaae na/iai? nenoaie ca 1981-1996 ??. ii Oa?e?anueeiio ?aa?iio, ye? na?ae/aoue i?i iayai?noue oaiaeaioe?? aei c?inoaiiy aaniethoii? e?eueeino? o?iaeaeaieo aaae ca inoaii? ?iee, ia?aaaaeii ca ?aooiie oeaieiieo aeenieac?e ie?ie, ?icaeoie yeeo caeaaeeoue iaea?eueo a?ae oyaeeino? iaoieia?/iiai noaio iaoa??. Eeth/ia? neiaa: ieiae, ie?ee, aanoic, ae?aaao oeoe?iaee, aeiia?oeiiao?eo, aiiiae?y. AIIIOAOeEss. Iaoiiaa I.A. Ii?oiooieoeeiiaeueiia ninoiyiea ii/ae ieiaeia io iaoa?ae n iicaeiei aanoicii, naoa?iui aeeaaaoii I oeia, o?iie/aneei aeiia?oeiiao?eoii a oneiaeyo Oa?ueeianeiai ?aaeiia. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.02. – iaoieiae/aneay aiaoiiey. – Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, 1999. Aeenna?oaoeey iinayuaia aii?inai ii?oiaaiaca ii/ae ieiaeia a oneiaeyo ioyaiuaiiiai iicaeiei aanoicii, naoa?iui aeeaaaoii I oeia, o?iie/aneei aeiia?oeiiao?eoii oa/aiey aa?aiaiiinoe o iaoa?ae. Iaoa?eaeii enneaaeiaaiey iineoaeeee 102 ia?u ii/ae ieiaeia a n?iea aanoaoeee 28-41 iaaeaey io iaoa?ae n naoa?iui aeeaaaoii (NAe) I oeia (26 neo/aaa), o?iie/aneei aeiia?oeiiao?eoii (OAI) (20 neo/aaa) e no?aaeathueo iicaeiei aanoicii (IA) (31 neo/ae), a n?aaiaiee n ii/eaie ieiaeia io caei?iauo iaoa?ae n oeceieiae/anee i?ioaeaaoae aa?aiaiiinoueth, iiaeaoeo io ino?iai ia?ooaiey ioiiaeiii-ieaoeaioa?iiai e?iaiia?auaiey e ?iaeiaie o?aaiu (25 neo/aaa). Iinea i?aaiiiao?e/aneiai enneaaeiaaiey eoni/ee ii/ae oeene?iaaee a 10% aiaeiii ?anoai?a iaeo?aeueiiai oi?iaeeia, iiaeaa?aaee nie?oiaie i?iaiaeea e caeeaaee a oeaeeieaeei-ia?aoei. Aenoieiae/aneea n?acu ie?aoeaaee aaiaoieneeeiii e yiceiii, iee?iooeneiii ii aai Aeciio, aieeeiiaui neiei ii Iaeei?e. Aeeeiaai auyaeyee a aenoieiae/aneeo n?acao ii iaoiaeo Aanoa (eiio?ieue OEE-?aaeoeey). Eiioiiii?oieiae/aneia enneaaeiaaiea i?iaaaeaii iai?yiui iaoiaeii Eoina n eniieueciaaieai ethieienoee?othueo nooeo e?iee/ueeo nuai?ioie i?ioea aeiaoeeiia /aeiaaea e IgA, M, G e N3-o?aeoeee eiiieaiaioa. Eieeaaaiu oeie?iaaeenue iai?yiui iaoiaeii Eoina n iiiiuueth IEA e eieeaaaiai I, III, IV, V oeiia. Ii?oiiao?e/aneia enneaaeiaaiea i?iaaaeaii niaeanii ?aeiiaiaeaoeeyi A.A. Aaoaiaeeeiaa (1990). Ii?aaeaeyee aaniethoiia eiee/anoai ?yaeia iao?iiia, ioiineoaeueiia eiee/anoai yia?eiiaeueiuo eeoai/eia, ioiineoaeueiua iauaiu eeoai/eia, eaiaeueoeaa, ninoaeia e eioa?noeoeey, n?aaeiee iauai ii/a/iuo eeoai/eia V1, eainoe V2, ioiioaiea V1:V2. N oeaeueth eco/aiey aeeyiey iineaaenoaee aaa?ee ia *AYN ia /anoioo e no?oeoo?o ii?ieia ?acaeoey ii/aaie nenoaiu i?iaaaeai aiaeec a?oeaiiai naeoeeiiiiai iaoa?eaea ieiaeia, iiai?iaeaeaiiuo e aeaoae a aic?anoa aei 14 eao ii i?icaeoo?ai a. Oa?ueeiaa ca ia?eiae n 1981 ii 1996 aiaea. I?e iae?ineiiee ioia/aii nieaeaiea ioiineoaeueiie iannu ii/ae a enneaaeoaiuo a?oiiao ii n?aaiaieth n eiio?ieai. Iaeiaiueoaa cia/aiea iieacaoaey eiaei ianoi i?e OAI o iaoa?e (0,72±0,02 % i?ioea 0,98±0,03% a eiio?iea), i?e IA e NAe - niioaaonoaaiii 0,91±03% e 0,95±0,03%. Ii?oiiao?e/anee auyaeaiu i?eciaee caiaaeeaiey oaiiia iao?iaaiaca, a aeaea nio?aiaiey aieueoaai eiee/anoaa ?yaeia iao?iiia e ioiineoaeueiiai eiee/anoaa yia?eiiaeueieo eeoai/eia: i?e OAI o iaoa?e – aaniethoiia eiee/anoai ?yaeia iao?iiia ninoaaeyei 11,7±0,5 (i?ioea 10,7±0,5 a eiio?iea), ioiineoaeueiia eiee/anoai yia?eiiaeueiuo eeoai/eia – 11,8±0,4% (i?ioea 9,6±0,4%, ?<0,01); i?e IA – niioaaonoaaiii 11,6±0,3 e 11,4±0,04 (?<0,01); i?e NAe o iaoa?e a ii/eao ieiaeia aaniethoiia eiee/anoai ?yaeia iao?iiia - 11,5±0,5, ioiineoaeueiia eiee/anoai yia?eiiaeueiuo eeoai/eia – 10,5±0,5%. Ia?yaeo n caaea?aeeie iao?iaaiaca a ii/eao ieiaeia enneaaeoaiuo a?oii auyaeyeenue i?eciaee ia?ooaiey aeeooa?aioee?iaee ii/a/iie oeaie a aeaea i/aaiauo oeaiaauo aeenieacee (IOAe) e i/aaiauo aeiia?oeiiaoee (IAI) n i?ieeoa?aoeaii-oea?iieanoe/aneeie eciaiaieyie (a eiio?iea ia auyaeyeenue). *anoioa yoeo eciaiaiee auea ?acee/iith: i?e IA o iaoa?e IOI ano?a/aeenue a 12,8% neo/aaa, IAI – a 9,7%; i?e NAe - a 15,4% e 22,2% niioaaonoaaiii, i?e OAI – a 20% e 30%. I?e aenoioeie/aneii enneaaeiaaiee a ii/eao ieiaeia io iaoa?ae n oyaeaeui oa/aieai naoa?iiai aeeaaaoa ioia/aeanue i/aaiaay eioeeueo?aoeey aeeeiaaiii yieoaeey ii/a/iuo eaiaeueoeaa. I?e eiioiiii?oieiae/aneii enneaaeiaaiee ii/ae ieiaeia eco/aaiuo a?oii ioia/aeinue ioeiaeaiea eiioiiuo eiiieaenia ia ninoaeenoi-iaia?aiiciuo no?oeoo?ao ii/ae (ca eneeth/aieai eiio?ieueiie a?oiiu). Niaeo? eiioiiaeiaoeeiia ioee/aeny a caaeneiinoe io iaoieiaee iaoa?e. I?e IA a ninoaa eiioiiuo eiiieaenia aoiaeeee Ig M e N3 o?aeoeey eiiieaiaioa (iaia?oaeeaaeenue o ieiaeia noa?oa 36 iaaeaeue aanoaoeee). I?e eaaeie oi?ia NAe o iaoa?e – a ii/eao ieiaeia auyaeyeny Ig G, a i?e oyaeaeie – Ig A,G e C3-o?aeoeey eiiieaiaioa. I?e OAI o iaoa?e – niaeo? eiioiiaeiaoeeiia naiue oe?ieee – IgA, M, G e N3-o?aeoeey eiiieaiaioa. I?e eiioiiii?oieiae/aneii eco/aiee oeiia eieeaaaia, ioia/aeanue caiaoiay aeoeaaoeey eieeaaaiia?aciaaiey I, III, IV e V oeiia a ii/eao ieiaeia io iaoa?ae n NAe I oeia, iniaaiii eieeaaaia IV e V oeiia aacaeueiie iaia?aiu ninoaeenouo eeoai/eia e a?oa?eie. I?e aanoica e OAI o iaoa?e a ii/eao ieiaeia n?aaee eioa?noeoeeaeueiuo eieeaaaiia oaaee/aia i?iaeoeoeey eieeaaaia I oeia, a a aacaeueiie iaia?aia – IV e V oeiia. Oaeei ia?acii, auyaeaiu i?eciaee caaea?aeee nic?aaaiey e ia?ooaiey aeeooa?aioee?iaee ii/a/iie oeaie; i/aaiaua aeeno?ioe/iua, i?ieeoa?aoeaiua, e oea?iieanoe/iua eciaiaiey eeoai/eia n ia?aciaaieai eiioiiuo eiiieaenia; iaeaeaiu i?eciaee aeoeaaoeee eieeaaaiiia?aciaaiey. Iieo/aiu ?acoeueoaou noaoenoe/aneiai enneaaeiaaiey a?iaeaeaiiuo ii?ieia ii/aaie nenoaiu ca 1981-1996 aa. ii Oa?ueeianeiio ?aaeiio, eioi?ua naeaeaoaeuenoaotho i oaiaeaioeee e ia?anoaieth aaniethoiiai eiee/anoaa a?iaeaeaiiuo ii?ieia a iineaaeiea aiaeu, i?aeiouanoaaiii ca n/ao oeaiaauo aeenieacee, ?acaeoea eioi?uo caaeneo i?aaeaea anaai io oyaeanoe iaoieiae/aneiai ninoiyiey iaoa?e. Eeth/aaua neiaa: ieiae, ii/ee, aanoic, aeeaaao naoa?iue, aeiia?oeiiao?eo, aiiiaeey. ANNOTATION. Naumova O.V. Morphofunctional condition of kidneys of fetuses from the mothers with late gestosis, diabetes mellitus (I type), chronic glomerulonephritis in conditions of the Kharkov region. - Manuscript. Thesis for a candidate degree by specialty 14.03.02 - Pathological Anatomy). Kharkiv State Medical University, Kharkiv, 1999. The thesis is devoted to questions of the morphogenesis of fetus kidneys in conditions of the burdened course of pregnancy at the mothers with late gestosis, diabetes mellitus (I type), chronic glomerulonephritis. The attributes of a delay of maturing and infringement of the differentiation of the renal tissue are revealed; focal degenerative, proliferate and fibroplastic changes of the glomeruli with formation of the immune complexes, the attributes of the activation of the collagen synthesis are found. The results of statistical research of inherent defects of the urinary system for 1981-1996 years are received. On the Kharkov region, which testify to the tendency to increase of absolute amount of inherent defects last years, mainly at the expense of tissue dysplasia, which development depends first of all on level of the mother pathological condition. Key words: fetus, kidneys, gestosis, diabetes mellitus, glomerulonephritis, anomaly.

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