.

Модифіковані ліпопротеїни: механізми утворення та роль в атерогенезі: Автореф. дис… д-ра мед. наук / Т.В. Талаєва, Укр. НДІ кардіології ім. М.Д.Стра

Язык: украинский
Формат: реферат
Тип документа: Word Doc
0 3819
Скачать документ

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO EA?Ae?IEIA??

?i. aeaae. I.Ae.NO?AAEANEA

OAEA?AA OAOssIA AIEIAeEIE??AIA

OAeE: 616.13 – 004.6 – 092 : 616.15

IIAeEO?EIAAI? E?III?IOA?IE:

IAOAI?CIE OOAI?AIIss OA ?IEUe A AOA?IAAIAC?

14.01.11 – Ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

Piaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea IIC Oe?a?ie

Iaoeiaee eiinoeueoaio :

aeieoi? iaaee/ieo iaoe, i?ioani? A?AOONUe A?eoi? Aaneeueiae/, caa?aeoaa/

eaai?aoi??? aenia?eiaioaeueii? ea?ae?ieia?? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea
IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani?, aeaaeai?e AII Oe?a?ie,
/eai-ei?aniiiaeaio IAI Oe?a?ie ? AII ?in?? EI?EOOEI Ieaa Aaneeueiae/,
ea??aiee a?aeae?eo a?eiai? o?c?ieia?? oa iaoieia?? aioo??oi?o i?aai?a
?inoeoooo aa?iioieia?? AII Oe?a?ie.

Aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio IAI Oe?a?ie

CAAA* Aaaeei Oaaei?iae/, canooiiee aee?aeoi?a c iaoeiai? ?iaioe,
ea??aiee a?aeae?eo o?c?ieia?? e?iaiia?ao ?inoeoooo o?c?ieia??
?i.I.I.Aiaiiieueoey IAI Oe?a?ie i.Ee?a.

3. Aeieoi? iaaee/ieo iaoe, i?ioani? AAIAeAO sse?a Aa?aiiae/, aieiaiee
iaoeiaee ni?a?ia?oiee a?aeae?eo iaaooeo aaae na?oey ?inoeoooo
na?oeaai-noaeeiii? o??o?a?? AII Oe?a?ie i.Ee?a.

I?ia?aeia i?aai?caoe?y: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey, eaoaae?a oaeoeueoaonueei? oa?ai?? ?2, IIC Oe?a?ie,
i.Ee?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 13 “_ea?oiy 1999 ?ieo i 10 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e
Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo? ea?ae?ieia??
?i.aeaae.I.Ae.No?aaeanea (252151, i.Ee?a, aoe. Ia?iaeiiai iiie/aiiy, 5)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea
(252151, i.Ee?a, aoe. Ia?iaeiiai iiie/aiiy, 5)

Aaoi?aoa?ao ?ic?neaiee “11 “aa?aciy 1999 ?ieo

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Aeaye
N.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aoa?ineea?ioe/ia o?aaeaiiy noaeeiii? nenoaie
eaaeeoue a iniia? iaea?eueo iioe?aieo oi?i ea?ae?aeueii? iaoieia?? ?
aecia/a? iiaeeea?noue ?icaeoeo aino?eo yaeu, ui i?ecaiaeyoue aei
caaeaae? /e ?iaae?aeecaoe?? oai?eo. Iae/ano?oa aoa?ineea?ic ooeiaeaeo?
noaeeie aeeoo?ai aaaeeeaeo i?aai?a – iiceo, na?oey, ie?ie, aeeeeeath/e
?icaeoie ?inoeueoo, ?ioa?eoo, na?oeaai? iaaeinoaoiino?, ? oiio ia
nueiaiaei?oi?e /an eiai ?icaeyaeathoue ye iaeio c aaaeo/eo i?e/ei
nia?oiino? ianaeaiiy ?iaeono??aeueii ?icaeiaieo e?a?i.

Iaoiaaiac aoa?ineea?ico aea/aiee aeineoue aeieeaaeii, i?ioa i?iaeaia
eiai ao?ieia?? caeeoa?oueny ua a?aee?eoith. A e?oa?aoo?? iienaii a?eueo
i?ae 100 oaeoi??a ?eceeo aoa?ineea?ico, aea i? iaeei c ieo ia ?
iaia”yceiaei aeey ?icaeoeo i?ioeano. Oea icia/a?, ui aai aoa?ineea?ic ?
iie?ao?ieia?/iei ca nai?th i?e?iaeith, aai iniiai? eiai oaeoi?e ?eceeo
?ioa?oa?othoueny ia iaeiiio ua oi/ii ia ?aeaioeo?eiaaiiio iaoai?ci?,
yeee ? ? aaciina?aaeiueith i?e/eiith anueiai eiiieaeno ci?i, ui
i?ecaiaeyoue aei o?aaeaiiy noaeeiii? nenoaie.

Aeine?aeaeaiiyie inoaii?o ?ie?a anoaiiaeaii, ui iaoiaaiac aoa?ineea?ico
iia”ycaiee c ii?ooaiiyie iai?io EI oa iiyaith a e?ia? oae caaieo
“iiaeeo?eiaaieo” ?o oi?i [Eeeiia A.I.,1995, Davies M.J.,1993, Leake
D.S., 1993]. O ca”yceo c oeei ieoaiiy i?i i?e?iaeo oa iaoai?cie
aoa?iaaiii? iiaeeo?eaoe?? EI iaaoei aeii?ioth/iai cia/aiiy o aea/aii?
iaoiaaiaco aoa?ineea?ico.

Iaea?eueo iioe?aiei oeiii iiaeeo?eiaaieo EI, ui ?ici?ciathoueny
neaaaiaeaea?-?aoeaioi?aie, ? EIIU, ye? caciaee a?eueii?aaeeeaeueiiai
ieeneaiiy a oiiaao ieneaeaoeaiiai no?ano [Gorog P.,1995, Lewis A.,1997],
iaei??th c iaeaaaeeea?oeo i?e/ei yeiai ? aeoeaaoe?y caiaeueieo ee?oei
e?ia?. Iaiaeii?aciai aoei iieacaii, ui eaeeioeeoe iathoue ?noioia
cia/aiiy aeey ?icaeoeo aoa?ineea?ico, ?ON oa ?? oneeaaeiaiue, i?ioa
i?eionea?oueny, ui ?o aeeth/aiiy a aoa?iaaiac a?aeaoaa?oueny aaea ia
aoai? cia/ieo ii?ooaiue e?i?aeiiai iai?io. Aeoeaoth/enue i?e oeueiio,
eaeeioeeoe caaacia/othoue aeaeaeaiiy c e?ia? aoa?iaaiieo EI. O?eueee a
inoaii?e /an o e?oa?aoo?? c’yaeeenue aeai?, ye? na?ae/aoue i?i oa, ui
o/anoue IOe a aoa?iaaiac? ? ia o?eueee iane?aeeii ii?ooaiue iai?io EI,
aea ? a cia/i?e i??? aecia/a? oe? ii?ooaiiy. Oea icia/a?, ui aeoeaaoe?y
IOe iiaea aooe a?aeianaia aei /enea iaeiiai c iaea?eueo ?aii?o oaeoi??a
?icaeoeo aoa?ineea?ico ?, iiaeeeai, iaeiiai c iaea?eueo aaaeeeaeo. E??i
oiai, IOe aeeth/athoueny a i?ioean o?aaeaiiy noaeeiii? no?iee aaea a
aeie?i?aeio noaae?th aoa?ineea?ico caaaeyee oiio, ui aa?ooue o/anoue a
i?ie?oa?aoe?? ?ioeie, a oaeiae i?aeaeuothoue iioaioe?ae cai?oaeueii?
nenoaie e?ia? a ?acoeueoao? i?iaeoeoe?? oa aeae?eaiiy oeaieiiiai oaeoi?o
[Carson, 1993, Crutchley, 1995]. Oea icia/a?, ui IOe iiaeooue a?aoe
o/anoue a ?icaeoeo an?o o?ueio iniiaieo eiiiiiaio?a aoa?ineea?ico –
e?i?aeiiai, neea?ioe/iiai oa eiaaoeyoe?eiiai.

Aeoeaaoe?y IOe ? iaeiei c aaaeo/eo oaeoi??a nenoaiiiai caiaeaiiy,
o/anoue yeiai a iaoiaaiac? aoa?ineea?ico aaaaea?oueny o oaia??oi?e /an
aacia?a/iith [Iayineee Ae.I.,1991, Moroi,1996]. A?eueoa oiai, o oe?ieiio
?icoi?ii? aoa?ineea?ic o?aeoo?oueny ye ?ioii-caiaeueia a?aeiia?aeue
?ioeie ia iioeiaeaeaiiy, ui ?i?oe?th?oueny e?i?aeaie, ye? a i?ioean?
iiaeeo?eaoe?? noathoue oiene/ieie aeey aiaeioae?ioeeo?a [Eeeiia A.I.,
Ieeoeue/aaa I.A.,1995]. Aeyaeaii, ui aeieeath/a a ?acoeueoao? eieaeueia
caiaeueia ?aaeoe?y aeeeeea? i?iaeoeoe?th oaeoi??a ?inoo o?iiaioeeoaie,
aiaeioae?ioeeoaie, aeaaeaiueeii”ycaaeie ee?oeiaie oa iae?ioaaaie, ui
i?eaiaeeoue aei iioiauaiiy ?ioeie oa ?icaeoeo aoa?ineea?ioe/ii? aeyoee
[Lassila,1993]. I?ioa ? ca?ac a?eueo?noue aeine?aeiee?a ?icaeyaea?
caiaeueiee i?ioean ye oaeoi?, ui ni?ey? i?enei?aiiio ?icaeoeo
aoa?ineea?ico, aea ia ye eiai naiino?eiee iaoiaaiaoe/iee iaoai?ci, a
ieoaiiy i?i cia/aiiy oa iaoai?cie i?iaoa?iaaiii? ae?? caiaeaiiy ua
eeoa?oueny a?aee?eoei.

Iaaaaeai? aeai? na?ae/aoue i?i oa, ui a i?iaeai? iaoiaaiaco
aoa?ineea?ico caa??aa?oueny ua aaaaoi iaae??oaieo ieoaiue. Aacia?a/ii,
ui iiiyooy aoa?ineea?ico ia’?aeio? ?yae aaaaoi a /iio iacaeaaeieo oeyo?a
ii?ooaiue iaoaaie?cio EI, na?aae yeeo ?iceaae iai?io ON oa aaaaoeo iei
EI aeyaeyaoueny, iiaeeeai, iaea?eueo iioe?aiei, aea ia ?aeeiei
iaoiaaiaoe/iei iaoai?ciii aeieeiaiiy oa ia?aa?ao caoai?thaaiiy. A oie
aea /an, ua iaia? ?aeeieo oyaeaiue a?aeiinii ieoiii? cia/ouino? eiaeiiai
c i?eaaaeaieo oaeoi??a o iaoiaaiac? aoa?ineea?ico oa ?ON, a oaeiae
iniaeeainoae ?o ii?aeiaiiy ia ??cieo aoaiao ?icaeoeo i?ioeano.

Ca”ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa “Iiaeeo?eiaai? e?iii?ioa?ie: iaoai?cie ooai?aiiy oa ?ieue a
aoa?iaaiac?” Oaea?ai? O.A. aeeiioaaeanue a ?aieao aea?aeaaii?
iaoeiai-oaoi?/ii? i?ia?aie “Caei?ia”y ethaeeie”, iai?yiie “Aoa?ineea?ic”
A?A 01008382 (AeIOI 17.0000.6292 ( 01.03.00/009-92) a eaai?aoi???
aenia?eiaioaeueii? ea?ae?ieia?? Oe?a?inueeiai iaoeiai-aeine?aeiiai
?inoeoooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeine?aeaeaiiy aoea ?ic?iaea
eiioeaioe?? iaoiaaiaco aoa?ineea?ico ia iniia? aecia/aiiy iaoai?ci?a
aeieeiaiiy iiaeeo?eiaaieo oi?i EI oa ?o ?ie? o oi?ioaaii? aoa?iaaiiiai
iioaioe?aeo ieacie ? noaiiaeaii? AOA, a oaeiae ?ic?iaea iiaiai iaoiaeo
aeiee?i?/ii? ae?aaiinoeee iayaiino? oa aeoeaiino? aoa?ineea?ioe/iiai
i?ioeano. Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaea/?:

1. Aecia/eoe iaea?eueo caeiiii??i? ci?ie iai?io EI e?ia? oa ?o
aca?iica’ycie c ae?aaeai?noth ? iioe?ai?noth AOA o oai?eo ?ON c
aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii.

2. Anoaiiaeoe ei?aeyoe?eio caeaaei?noue i?ae ai?noii caaaeueiiai ON
e?ia? oa nooiaiai ?? aoa?iaaiiino? o oai?eo ?ON c iaoith aecia/aiiy ?ie?
AOA o iaoiaaiac? aoa?ineea?ioe/iiai i?ioeano.

3. Aecia/eoe ?ieue ieneaeaoeaiiai no?ano a i?ioean? aoa?iaaiii?
iiaeeo?eaoe?? EI e?ia? oa i?aeaeuaii? ??aiy aoa?iaaiiino? ieacie o
oai?eo c o?ii?/iei ia?aa?aii ?ON, o oai?eo c aino?eie caiaeueieie
caoai?thaaiiyie, a oaeiae i?e aenia?eiaioaeueiiio iiaeaethaaii? aino?iai
caiaeueiiai i?ioeano.

4. Aecia/eoe ?ieue aeoeaaoe?? IOe o ?icaeoeo ieneaeaoeaiiai no?ano.

5. Anoaiiaeoe iaoai?cie ?icaeoeo AOA oa aoa?iaaiii? iiaeeo?eaoe?? EI
i?e iaaei??iiio iaaeoiaeaeaii? aeciaaiiiai ON o oaa?ei a oiiaao
oo?eiaiiy ia aoa?iaaii?e ae??o?.

6. Aecia/eoe iiaeeea?noue nainea?e?caoe?? nenoaie iaoaaie?cio EI aei
iaae?aoi??a caiaeaiiy oa noiaoe?? aeieeath/eo ii?ooaiue i?e iiaoi?iiio
a?aeoai?aii? caiaeueiiai i?ioeano.

7. Anoaiiaeoe i?e/eiii-iane?aeeiao caeaaei?noue i?ae aeoeaaoe??th IOe,
i?aeaeuaiiyi ?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a oa ii?ooaiiyi
iaoaaie?cio EI ye o oai?eo c ee?i?/ieie i?iyaaie aoa?ineea?ico ? o
ae?oae c aino?eie caiaeueieie caoai?thaaiiyie, oae ? i?e
aenia?eiaioaeueiiio iiaeaethaaii? aino?iai caiaeueiiai i?ioeano.

8. Anoaiiaeoe cia/ou?noue aioeieneaeaioii? oa?ai?? o ia?aeii?e oa
aoi?eii?e i?io?eaeoeoe? aoa?ineea?ico.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii, ui aaaeo/ei
iaoiaaiaoe/iei iaoai?ciii ?icaeoeo aoa?ineea?ico oa eiai ee?i?/ieo
i?iya?a ? c?inoaiiy aoa?iaaiiiai iioaioe?aeo e?ia?, coiiaeaia
iaeiie/aiiyi a i?e iiaeeo?eiaaieo EI. Iieacaii, ui AOA ia ?
oi?aa?naeueiei oaeoi?ii aoa?iaaiaco ? a?aei?/a?oueny o?eueee o 60-65%
oai?eo ?ON c aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii. Ia iniia?
a?aenooiino? i?yii? ei?aeyoe?eii? caeaaeiino? i?ae ai?noii caaaeueiiai
ON o e?ia? oa nooiaiai aoa?iaaiiino? ieacie aia?oa c?iaeaii aeniiaie i?i
oa, ui AOA ? a a?eueo?e i??? iaoiaaiaoe/iei, i?ae ao?ieia?/iei oaeoi?ii
aoa?ineea?ico ? iiaeiia ?icaeyaeaoenue ye ia?ea? aeniei? aeoeaiino?
iaoai?ci?a, ui coiiaeththoue ii?ooaiiy iaoaaie?cio EI. O ?iaio? aia?oa
anoaiiaeaii, ui aoa?iaaiee iioaioe?ae ieacie o oai?eo ?ON oa a oiiaao
aino?iai caiaeaiiy a cia/i?e i??? aecia/a?oueny iaeiie/aiiyi o e?ia?
iiaeeo?eiaaieo EI aiane?aeie ?icaeoeo ieneaeaoeaiiai no?ano oa
aeoeaaoe?? IIE. I?aeoaa?aeaeaii i?eiouaiiy, ui i?e/eiith aeieeiaiiy
ieneaeaoeaiiai no?ano ye i?e i?e?iaeiiio ?icaeoeo caiaeueiiai i?ioeano,
oae ? i?e eiai iiaeaethaaii? a oiiaao aenia?eiaioo ? aeoeaaoe?y
caiaeueieo ee?oei e?ia?. Aeiaaaeaii, ui iniiaith i?e/eiii-iane?aeeiai?
caeaaeiino? i?ae aeoeaaoe??th ee?oei e?ia? oa ii?ooaiiyie iai?io EI,
anoaiiaeaiith ye o oai?eo c ee?i?/ieie i?iyaaie aoa?ineea?ico oa o
ae?oae c aino?eie caiaeueieie caoai?thaaiiyie, oae ? i?e
aenia?eiaioaeueiiio iiaeaethaaii? aino?iai caiaeaiiy, ? i?aeaeuaiiy
?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a. Aia?oa iieacaii, ui i?e
iaaei??iiio iaaeoiaeaeaii? a i?aai?ci aeciaaiiai ON a oiiaao oo?eiaiiy
oaa?ei ia aoa?iaaii?e ae??o? AOA ?icaeaa?oueny ca i?eioeeiii ii?i/iiai
eiea c iine?aeiaiei aeeth/aiiyi ie?aieo iaoiaaiaoe/ieo iaoai?ci?a oa ?c
no?ae/anoei c?inoaiiyi ??aiy caaaeueiiai ON o e?ia?. I?e oeueiio AOA
aeieea? ia?aeiii, oiae? ye iiyaa aoa?iaaiieo aeanoeainoae ieacie ia?
aoi?eiiee oa?aeoa?; a oeeo oiiaao aeoeaaoe?y a?eueii?aaeeeaeueieo
?aaeoe?e ? oaeoi?ii, ui i?aeneeth? aoa?iaaiio iiaeeo?eaoe?th EI e?ia?.
A?aoiaoth/e ao?ieia?/io cia/ou?noue ieneaeaoeaieo i?ioean?a a
aoa?iaaii?e iiaeeo?eaoe?? EI e?ia? oa ?icaeoeo AOA, aeiaaaeaii, ui
aioeieneaeaioia oa?ai?y iiaeiia ?icaeyaeaoenue ye iaeaaaeeea?oee oeyo
ia?aeiii? oa aoi?eiii? i?io?eaeoeee aoa?ineea?ico, ieneaeaoeaiiai no?ano
oa iaeiie/aiiy o e?ia? aoa?iaaiieo EI.

Oai?aoe/ia oe?ii?noue. ?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy
aeicaieeee aecia/eoe iiaee iaoiaaiaoe/iee aa??aio ?icaeoeo AOA ye
iane?aeeo aoa?iaaiii? iiaeeo?eaoe?? EI oa anoaiiaeoe ?ieue
ieneaeaoeaiiai no?ano a ?acoeueoao? aeoeaaoe?? IOe e?ia? a yeino?
oaeoi?a, ui ?i?oe?th? ii?ooaiiy iai?io EI e?ia?, ?icaeoie AOA oa
eieaeueia ?aiiaeaethaaiiy noaeeiii? no?iee.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aecia/aiiy iaoai?ci?a, ui
?i?oe?ththoue aoa?iaaiio iiaeeo?eaoe?th EI oa ?icaeoie AOA, aeicaieeei
aecia/eoe ae?aaiinoe/i? e?eoa??? ii/aoeiaeo aoai?a aoa?iaaiaco, a oaeiae
anoaiiaeoe iiaeeeaino? iiia?aaeaeaiiy ?icaeoeo oeeo ci?i ca aeiiiiiaith
iai?aaeaiiai i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? IOe oa
?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a a e?ia?. Aeiaaaeaia
aeioe?euei?noue i?iaaaeaiiy aioeieneaeaioii? oa?ai?? aeey ia?aeiii? oa
aoi?eiii? i?io?eaeoeee ii?ooaiue iai?io EI e?ia?. ?ic?iaeaiee oa
ai?iaiaaiee o a?aeae?e? aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae
na?oey Oe?a?inueeiai IAe? ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea iaoiae
a?ioanooaaiiy aoa?iaaiiino? ieacie ca aeiiiiiaith eoeueoo?e II, yeee
iiaea ciaeoe canoinoaaiiy a ai?aeai?ieia?/ieo oa iaoeiaeo
aeine?aeaeaiiyo aeey aeyaeaiiy ?aii?o aeiee?i?/ieo oi?i ii?ooaiue iai?io
EI e?ia?.

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue, ui aeicaieeee noi?ioaaoe iiao
eiioeaioe?th iaoiaaiaco aoa?ineea?ico ia iniia? aecia/aiiy iaoai?ci?a
aeieeiaiiy iiaeeo?eiaaieo oi?i EI oa ?o ?ie? o oi?ioaaii? aoa?iaaiiiai
iioaioe?aeo ieacie ? noaiiaeaii? AOA, cai?iaaaeaeaii o eaeoe?eiee eo?n
eaoaae?e aini?oaeueii? oa?ai?? ?2 ? EOE Aoeiaeinueei? aea?aeaaii?
iaaee/ii? aeaaeai??.

?acoeueoaoe oa iniiai? iieiaeaiiy ?iaioe aeei?enoiaothoueny o ?iaio?
ea?ae?ieia?/ieo a?aeae?eaiue iaoeiai-aeine?aeiiai ?inoeoooo “Iaaeeoeeia
o?ainii?oo” i.Iaeana, Oeaio?aeueii? o?ainii?oii? ee?i?/ii? e?ea?i?
i.Ee?aa oa Aieeinueei? iaeanii? ee?i?/ii? e?ea?i?, i?i ui na?ae/aoue
aeoe ai?iaaaeaeaiiy.

Io?eiaii iiceoeaia ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae ? 98052453.

Iniaenoee aianie caeiaoaa/a iieyaa? o naiino?eiiio i?iaaaeaii?
aeine?aeaeaiue ii aecia/aiith ??aiy ooieoe?iiaeueii? aeoeaiino?
oee?eoethth/eo IOe, a?ioanooaaiith aoa?iaaiiino? e?ia?, aecia/aiith
noia?iiai ??aiy ia?ieneaeaoe?? e?i?ae?a ieacie oa noaio ??
aioeieneaeaioiiai iioaioe?aeo iaoiaeii OE, aecia/aiith aeoeaiino?
eaoaeace e?ia? oai?eo ?ON, ae?oae c aino?eie caiaeueieie caoai?thaaiiyie
i?aai?a aeeoaiiy, a oaeiae oaa?ei i?e aenia?eiaioaeueiiio iiaeaethaaii?
aino?iai caiaeueiiai i?ioeano oa ae?iaioa?ii? AOA. Aaoi?ii caiino?eii
a?aeoai?aia i?ea?iaeueia iiaeaeue aino?iai caiaeueiiai i?ioeano ca
aeiiiiiaith aioo??oiueiaaiiiai aaaaeaiiy e?ieeeai eaoaenieo i?e?inoa?
aai i??iaaiaeo, a oaeiae iiaeaeue ae?iaioa?ii? AOA o e?ieee?a oeyoii
o?eaaeiai oo?eiaiiy ia aoa?iaaii?e ae??o?. Ae?aaiic ?ON o oai?eo aoa
aa?eo?eiaaiee ca aeiiiiiaith i?iae c aeiciaaiei o?ce/iei iaaaioaaeaiiyi
ni?a?ia?oieeaie a?aeae?eo aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae
na?oey aai ei?iia?iaia?ia?ao??, i?iaaaeaii? ni?a?ia?oieeaie a?aeae?eaiiy
ei?iia?ii? oa ?aioaai-aiaeiaaneoey?ii? o??o?a??. *anoeiai e?i?aeiee
niaeo? e?ia? oai?eo ?ON aeine?aeaeaii a eaai?aoi??? ee?i?/ii? a?io?i??,
ii?oieia?/iee eiio?ieue no?oeoo?ieo ci?i no?iee ai?oe e?ieee?a aoa
i?iaaaeaiee aaaeo/ei iaoeiaei ni?a?ia?oieeii eaai?aoi??? iaoiii?oieia??
Oe?a?inueeiai IAe? ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea e.i.i.
I.A.Na?a??iei. Aaoi?ii iniaenoi i?iaaaeai? i?aeaioiaea ia?aeiieo aeaieo
aeey ia?iaee IAII, ia?aeiiee iieniaee oa ii??aiyeueiee noaoenoe/iee
aiae?ce, ei?aeyoe?eiee aiae?c ?acoeueoao?a ia IAII. Aeniiaee
aeena?oaoe?eii? ?iaioe c?iaeai? aaoi?ii iniaenoi.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
iaaiai?ai? ia XIII c”?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa ?i.
?.I.Iaaeiaa (Oa?e?a,1990), ?anioae?eainuee?e iaoeia?e eiioa?aioe??
(Oa?e?a,1991), eiioa?aioe?? iaoio?c?ieia?a Oe?a?ie (Aei?i?iiao?ianuee,
1992), iaoeia?e eiioa?aioe?? “Iiaia a eeeie/aneie oa?iaeieiaee e
oa?iaeioa?aiee caaieaaaiee aioo?aiieo i?aaiia” (Oa?e?a, 1992), IO
c”?cae? ea?ae?ieia?a Oe?a?ie (Aei?i?iiao?ianuee, 1993),
?anioaeeeainuee?e iaoeia?e eiioa?aioe?? “Aeooaeueiua aii?inu iaoiaaiaca,
aeeaaiinoeee e ea/aiey aoa?ineea?ica e eoaie/aneie aieacie na?aeoea
(Oa?e?a, 1994), O I?aeia?iaeiiio eiia?an? ea?ae?ieia?a Oe?a?ie (Ee?a,
1997), OO Annual International Society for Heart Research Meeting
(Columbia, 1993), 4-th World Congress on Heart Failure (Jerusalem,1996),
5-th Alpe-Adria Nardiology Meeting in Austria (Graz,1997), 5-th World
Congress on Heart Failure (Washington,1997), O c”?cae? oa?aiaao?a
Oe?a?ie (Ee?a, 1998), ieaioi? i?aae?iiy iaoeiaiai oiaa?enoaa
ea?ae?ieia?a Oe?a?ie “Aoa?ineea?ic oa ?oai?/ia oai?iaa na?oey: no/ani?
aniaeoe i?io?eaeoeee, ae?aaiinoeee oa e?eoaaiiy” (Ee?a, 1998).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 18 aeo?iaeueieo
noaoae, c ieo – 5 aac ni?aaaoi??a, 20 oac o iaoa??aeao eiioa?aioe?e,
c”?cae?a, eiia?an?a.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, 3 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy,
aeniiae?a oa nieneo aeei?enoaieo aeaea?ae. ?iaioa aeeeaaeaia ia 311
noi??ieao iaoeiiieniiai oaenoo, ?ethno?iaaia 15 oaaeeoeyie ? 25
iaethieaie. A?ae?ia?ao?/iee iieaae/ee i?noeoue 452 aeaea?aea, c ieo 118
ee?eeeoeath.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Iaoa oa caaea/? aeaii? ?iaioe ae??ooaaeenue oeyoii eiiieaeniiai
ianoaaeaiiy oai?eo ?ON c aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii, ae?oae
c aino?eie caiaeueieie caoai?thaaiiyie, a oaeiae oeyoii i?iaaaeaiiy
a?aeiia?aeieo aeine?aeaeaiue i?e aenia?eiaioaeueiiio iiaeaethaaii?
aino?iai caiaeueiiai i?ioeano oa ae?iaioa?ii? AOA.

Aeine?aeaeaiiy i?iaaaeaii ia 127 iaoe??ioao c ?ON (/ieia?ee o
a?oe? a?ae 32 aei 63 ?ie?a), ui ciaoiaeeeenue ia e?eoaaii? o
a?aeae?eaii? aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae na?oey
Oe?a?inueeiai IAe? ea?ae?ieia??. Ae?aaiic ?ON aoa aa?eo?eiaaiee ca
aeiiiiiaith ei?iia?iaia?ia?ao?? aai i?iae c aeiciaaiei o?ce/iei
iaaaioaaeaiiyi. C a?oie ianoaaeaieo aeeeth/aeenue oai?? ?c noiooi?ie
o?ii?/ieie caoai?thaaiiyie aioo??oi?o i?aai?a oa iaaeinoaoi?noth
e?iaiia?ao (IE IIA-III). Eiio?ieueio a?oio neeaee 15 i?aeoe/ii caei?iaeo
in?a /ieia?/i? noao? oaei? ae a?eiai? eaoaai???, ye ? a aeine?aei?e
a?oi?.

Aeine?aeaeoaaeenue 15 ae?oae o a?oe? a?ae 1,5 aei 8 ?ie?a ia aenio?
?icaeoeo aino?iai caiaeueiiai caoai?thaaiiy i?aai?a aeeoaiiy
?ioaeoe?eii? i?e?iaee aac iciae ii?ooaiue e?i?aeiiai iai?io a aiaiiac?,
a oaeiae aeiaeaoeiai 5 oai?eo, ui i?ieoee eo?n i?ioecaiaeueii? oa?ai??
i?ney ii?iae?caoe?? oaiia?aoo?e o?ea oa cieeiaiiy ia’?eoeaieo iciae
caoai?thaaiiy.

Ae?iaioa?io AOA a?aeoai?thaaee o 22 e?ie?a oeyoii ?o oo?eiaiiy ia
i?ioyc? 8 oeaei?a ia aoa?iaaii?e ae??o? ?c ?ic?aooieo 0,2 a ON ia 1 ea
aaae oaa?eie. Aino?ee caiaeueiee i?ioean a?aeoai?thaaee ia 12 caei?iaeo
e?ieyo, yeeo oo?eioaaee ia noaiaea?oi?e ae??o?, oeyoii
aioo??oiueiaaiiiai aaaaeaiiy 1,6 ie 2,5% noniaic?? eaoaenieo i?e?inoa? 3
?ace /a?ac aeaiue; ie?aio a?oio neeaee 6 oaa?ei, yeei i?e?inoa?e
aaiaeeee iaeii?aciai a aiaeia?/i?e aeic?. 12 e?ieyi ia i?ioyc? 2-o
oeaei?a aei a?aeoai?aiiy aino?iai caiaeueiiai neiae?iio oa i?ae /an
anueiai aenia?eiaioo i?iaiaeeee i?io?eaeoe/io aioeieneaeaioio oa?ai?th
(eiiieaen aee?i- oa aiaei?ic/eiieo aioeieneaeaioieo a?oai?i?a –
anei?a?iiai? eeneioe 100 ia/ea aaae oa oieioa?ieo aoeaoaoo 33 ia/ea aaae
a aeaiue). O ae?oa?e na??? aeine?ae?a, ui oaeiae aeeth/aea 12 oaa?ei,
aeey iiaeaethaaiiy aino?iai caiaeaiiy canoiniaoany i??iaaiae ii 10 IIAe
ii aiaeia?/i?e noai?.

Iieacieee iai?io e?i?ae?a aeeth/aee aecia/aiiy ??aiy caaaeueiiai ON, OA
oa EIAU oa?iaioaoeaiei iaoiaeii ia e?i?aeiiio aaoiaiae?caoi??
“Technicon”. E?euee?noue iiaeeo?eiaaieo EI o ne?iaaooe? e?ia? aecia/aee
?c aeei?enoaiiyi eoeueoo?e II (Oa?oia A.A.,1990). Aeey aeae?eaiiy IOe
e?ia? aeei?enoiaoaaee iaoiae oeaio?eooaoaaiiy o a?aae??io? u?eueiino? ii
Recalde (1984). Aecia/aee ai?no ON o oee?eoethth/eo IOe oa ?o
caeaoi?noue iiaeeiaoe EI e?ia? i?e aeiaeaoeia?e noeioeyoe??, aeeeeeai?e
aeae?eaiiyi oa eoeueoeaoaaiiyi, ui aeicaieeei noaeeoe i?i i?eoiaaio
?aaeoeai?noue IOe. Ai?no ON o eoeueoo?? ee?oei oa ??aaiue caaaeueiiai ON
o ieaci? e?ia? aecia/aee ca iaoiaeii ?eueea (1987), ai?no ee?oeiiiai
a?eea – ca iaoiaeii Eio?? (1991). A yeino? iieaciee?a aeoeaiino? IIE o
IOe aeei?enoiaoaaee aioo??oiueiee?oeiiee ai?no IAeA (Eieaniaa
I.A.,1984). Nooi?iue aeoeaaoe?? oee?eoethth/eo IOe ioe?ithaaee ii
oaaioeeoa?i?e aeoeaiino?, yeo aecia/aee noaiaea?oiei iaoiaeii ca
aeiiiiiaith i?e?inoa? eaoaeno (Iioaiiaa N.A.,1977), a oaeiae ii
caeaoiino? i?iaeoeoaaoe ieneae acioo (Eooaeianeee I.N.,1971). Ia?aa?a
a?eueii?aaeeeaeueieo ?aaeoe?e a ieaci? e?ia? eiio?iethaaee ca noia?iei
ai?noii a?ae?iia?aeen?a e?i?ae?a (Aaa?eeia A.A.,1987), AeE (Asakawa T.
et al., 1980) oa IAeA, yeee aecia/aee c aeei?enoaiiyi o?iaa?a?oo?iai?
eeneioe (Asakawa T. et al., 1980). Aeey aecia/aiiy ?ioaa?aeueii?
oa?aeoa?enoeee ia?aa?ao a?eueii?aaeeeaeueieo ?aaeoe?e oa noaio
aioeieneaeaioii? nenoaie e?ia? aeei?enoiaoaaee iaoiae OE (Na?e?c
ss.?.,1988), a oaeiae aeoeai?noue eaoaeace e?ia? (Ei?iethe I.A.,1988,
Aeinii ?., 1991).

Ii?oieia?/i? aeine?aeaeaiiy no?oeoo?ieo ci?i no?iee ai?oe
i?iaiaeeee ?c aeei?enoaiiyi noaiaea?oieo iaoiaeee.

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe

O ianoaaeaieo oai?eo niinoa??aaeenue cia/i? ii?ooaiiy iai?io EI o
aeaeyae? ca?eueoaiiy ai?noo caaaeueiiai ON a na?aaeiueiio aei 6,27+0,20
iI/e, ui ia 21% (?0,05). AOA
iaaoaaea caeiiii??iiai oa?aeoa?o /a?ac 4-5 oeaei?a, eiee ai?no ON aoa
ca?eueoaiee o 8,7 ?ac?a (a?ae 1,44+0,18 aei 12,46+1,12 iI/e, ?0,05), a iaeneiaeueia caoiieaiiy EI IOe e?ia? o ipioean?
eoeueoeaoaaiiy a eiio?ieuei?e a?oi? aoei iaioa ia 24% (?

Нашли опечатку? Выделите и нажмите CTRL+Enter

Похожие документы
Обсуждение

Оставить комментарий

avatar
  Подписаться  
Уведомление о
Заказать реферат!
UkrReferat.com. Всі права захищені. 2000-2020