I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO EA?Ae?IEIA??

?i. aeaae. I.Ae.NO?AAEANEA

OAEA?AA OAOssIA AIEIAeEIE??AIA

OAeE: 616.13 — 004.6 — 092 : 616.15

IIAeEO?EIAAI? E?III?IOA?IE:

IAOAI?CIE OOAI?AIIss OA ?IEUe A AOA?IAAIAC?

14.01.11 — Ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

Piaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea IIC Oe?a?ie

Iaoeiaee eiinoeueoaio :

aeieoi? iaaee/ieo iaoe, i?ioani? A?AOONUe A?eoi? Aaneeueiae/, caa?aeoaa/

eaai?aoi??? aenia?eiaioaeueii? ea?ae?ieia?? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea
IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani?, aeaaeai?e AII Oe?a?ie,
/eai-ei?aniiiaeaio IAI Oe?a?ie ? AII ?in?? EI?EOOEI Ieaa Aaneeueiae/,
ea??aiee a?aeae?eo a?eiai? o?c?ieia?? oa iaoieia?? aioo??oi?o i?aai?a
?inoeoooo aa?iioieia?? AII Oe?a?ie.

Aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio IAI Oe?a?ie

CAAA* Aaaeei Oaaei?iae/, canooiiee aee?aeoi?a c iaoeiai? ?iaioe,
ea??aiee a?aeae?eo o?c?ieia?? e?iaiia?ao ?inoeoooo o?c?ieia??
?i.I.I.Aiaiiieueoey IAI Oe?a?ie i.Ee?a.

3. Aeieoi? iaaee/ieo iaoe, i?ioani? AAIAeAO sse?a Aa?aiiae/, aieiaiee
iaoeiaee ni?a?ia?oiee a?aeae?eo iaaooeo aaae na?oey ?inoeoooo
na?oeaai-noaeeiii? o??o?a?? AII Oe?a?ie i.Ee?a.

I?ia?aeia i?aai?caoe?y: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey, eaoaae?a oaeoeueoaonueei? oa?ai?? ?2, IIC Oe?a?ie,
i.Ee?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 13 “_ea?oiy 1999 ?ieo i 10 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e
Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo? ea?ae?ieia??
?i.aeaae.I.Ae.No?aaeanea (252151, i.Ee?a, aoe. Ia?iaeiiai iiie/aiiy, 5)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea
(252151, i.Ee?a, aoe. Ia?iaeiiai iiie/aiiy, 5)

Aaoi?aoa?ao ?ic?neaiee “11 “aa?aciy 1999 ?ieo

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Aeaye
N.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aoa?ineea?ioe/ia o?aaeaiiy noaeeiii? nenoaie
eaaeeoue a iniia? iaea?eueo iioe?aieo oi?i ea?ae?aeueii? iaoieia?? ?
aecia/a? iiaeeea?noue ?icaeoeo aino?eo yaeu, ui i?ecaiaeyoue aei
caaeaae? /e ?iaae?aeecaoe?? oai?eo. Iae/ano?oa aoa?ineea?ic ooeiaeaeo?
noaeeie aeeoo?ai aaaeeeaeo i?aai?a — iiceo, na?oey, ie?ie, aeeeeeath/e
?icaeoie ?inoeueoo, ?ioa?eoo, na?oeaai? iaaeinoaoiino?, ? oiio ia
nueiaiaei?oi?e /an eiai ?icaeyaeathoue ye iaeio c aaaeo/eo i?e/ei
nia?oiino? ianaeaiiy ?iaeono??aeueii ?icaeiaieo e?a?i.

Iaoiaaiac aoa?ineea?ico aea/aiee aeineoue aeieeaaeii, i?ioa i?iaeaia
eiai ao?ieia?? caeeoa?oueny ua a?aee?eoith. A e?oa?aoo?? iienaii a?eueo
i?ae 100 oaeoi??a ?eceeo aoa?ineea?ico, aea i? iaeei c ieo ia ?
iaia”yceiaei aeey ?icaeoeo i?ioeano. Oea icia/a?, ui aai aoa?ineea?ic ?
iie?ao?ieia?/iei ca nai?th i?e?iaeith, aai iniiai? eiai oaeoi?e ?eceeo
?ioa?oa?othoueny ia iaeiiio ua oi/ii ia ?aeaioeo?eiaaiiio iaoai?ci?,
yeee ? ? aaciina?aaeiueith i?e/eiith anueiai eiiieaeno ci?i, ui
i?ecaiaeyoue aei o?aaeaiiy noaeeiii? nenoaie.

Aeine?aeaeaiiyie inoaii?o ?ie?a anoaiiaeaii, ui iaoiaaiac aoa?ineea?ico
iia”ycaiee c ii?ooaiiyie iai?io EI oa iiyaith a e?ia? oae caaieo
“iiaeeo?eiaaieo” ?o oi?i [Eeeiia A.I.,1995, Davies M.J.,1993, Leake
D.S., 1993]. O ca”yceo c oeei ieoaiiy i?i i?e?iaeo oa iaoai?cie
aoa?iaaiii? iiaeeo?eaoe?? EI iaaoei aeii?ioth/iai cia/aiiy o aea/aii?
iaoiaaiaco aoa?ineea?ico.

Iaea?eueo iioe?aiei oeiii iiaeeo?eiaaieo EI, ui ?ici?ciathoueny
neaaaiaeaea?-?aoeaioi?aie, ? EIIU, ye? caciaee a?eueii?aaeeeaeueiiai
ieeneaiiy a oiiaao ieneaeaoeaiiai no?ano [Gorog P.,1995, Lewis A.,1997],
iaei??th c iaeaaaeeea?oeo i?e/ei yeiai ? aeoeaaoe?y caiaeueieo ee?oei
e?ia?. Iaiaeii?aciai aoei iieacaii, ui eaeeioeeoe iathoue ?noioia
cia/aiiy aeey ?icaeoeo aoa?ineea?ico, ?ON oa ?? oneeaaeiaiue, i?ioa
i?eionea?oueny, ui ?o aeeth/aiiy a aoa?iaaiac a?aeaoaa?oueny aaea ia
aoai? cia/ieo ii?ooaiue e?i?aeiiai iai?io. Aeoeaoth/enue i?e oeueiio,
eaeeioeeoe caaacia/othoue aeaeaeaiiy c e?ia? aoa?iaaiieo EI. O?eueee a
inoaii?e /an o e?oa?aoo?? c’yaeeenue aeai?, ye? na?ae/aoue i?i oa, ui
o/anoue IOe a aoa?iaaiac? ? ia o?eueee iane?aeeii ii?ooaiue iai?io EI,
aea ? a cia/i?e i??? aecia/a? oe? ii?ooaiiy. Oea icia/a?, ui aeoeaaoe?y
IOe iiaea aooe a?aeianaia aei /enea iaeiiai c iaea?eueo ?aii?o oaeoi??a
?icaeoeo aoa?ineea?ico ?, iiaeeeai, iaeiiai c iaea?eueo aaaeeeaeo. E??i
oiai, IOe aeeth/athoueny a i?ioean o?aaeaiiy noaeeiii? no?iee aaea a
aeie?i?aeio noaae?th aoa?ineea?ico caaaeyee oiio, ui aa?ooue o/anoue a
i?ie?oa?aoe?? ?ioeie, a oaeiae i?aeaeuothoue iioaioe?ae cai?oaeueii?
nenoaie e?ia? a ?acoeueoao? i?iaeoeoe?? oa aeae?eaiiy oeaieiiiai oaeoi?o
[Carson, 1993, Crutchley, 1995]. Oea icia/a?, ui IOe iiaeooue a?aoe
o/anoue a ?icaeoeo an?o o?ueio iniiaieo eiiiiiaio?a aoa?ineea?ico —
e?i?aeiiai, neea?ioe/iiai oa eiaaoeyoe?eiiai.

Aeoeaaoe?y IOe ? iaeiei c aaaeo/eo oaeoi??a nenoaiiiai caiaeaiiy,
o/anoue yeiai a iaoiaaiac? aoa?ineea?ico aaaaea?oueny o oaia??oi?e /an
aacia?a/iith [Iayineee Ae.I.,1991, Moroi,1996]. A?eueoa oiai, o oe?ieiio
?icoi?ii? aoa?ineea?ic o?aeoo?oueny ye ?ioii-caiaeueia a?aeiia?aeue
?ioeie ia iioeiaeaeaiiy, ui ?i?oe?th?oueny e?i?aeaie, ye? a i?ioean?
iiaeeo?eaoe?? noathoue oiene/ieie aeey aiaeioae?ioeeo?a [Eeeiia A.I.,
Ieeoeue/aaa I.A.,1995]. Aeyaeaii, ui aeieeath/a a ?acoeueoao? eieaeueia
caiaeueia ?aaeoe?y aeeeeea? i?iaeoeoe?th oaeoi??a ?inoo o?iiaioeeoaie,
aiaeioae?ioeeoaie, aeaaeaiueeii”ycaaeie ee?oeiaie oa iae?ioaaaie, ui
i?eaiaeeoue aei iioiauaiiy ?ioeie oa ?icaeoeo aoa?ineea?ioe/ii? aeyoee
[Lassila,1993]. I?ioa ? ca?ac a?eueo?noue aeine?aeiee?a ?icaeyaea?
caiaeueiee i?ioean ye oaeoi?, ui ni?ey? i?enei?aiiio ?icaeoeo
aoa?ineea?ico, aea ia ye eiai naiino?eiee iaoiaaiaoe/iee iaoai?ci, a
ieoaiiy i?i cia/aiiy oa iaoai?cie i?iaoa?iaaiii? ae?? caiaeaiiy ua
eeoa?oueny a?aee?eoei.

Iaaaaeai? aeai? na?ae/aoue i?i oa, ui a i?iaeai? iaoiaaiaco
aoa?ineea?ico caa??aa?oueny ua aaaaoi iaae??oaieo ieoaiue. Aacia?a/ii,
ui iiiyooy aoa?ineea?ico ia’?aeio? ?yae aaaaoi a /iio iacaeaaeieo oeyo?a
ii?ooaiue iaoaaie?cio EI, na?aae yeeo ?iceaae iai?io ON oa aaaaoeo iei
EI aeyaeyaoueny, iiaeeeai, iaea?eueo iioe?aiei, aea ia ?aeeiei
iaoiaaiaoe/iei iaoai?ciii aeieeiaiiy oa ia?aa?ao caoai?thaaiiy. A oie
aea /an, ua iaia? ?aeeieo oyaeaiue a?aeiinii ieoiii? cia/ouino? eiaeiiai
c i?eaaaeaieo oaeoi??a o iaoiaaiac? aoa?ineea?ico oa ?ON, a oaeiae
iniaeeainoae ?o ii?aeiaiiy ia ??cieo aoaiao ?icaeoeo i?ioeano.

Ca”ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa “Iiaeeo?eiaai? e?iii?ioa?ie: iaoai?cie ooai?aiiy oa ?ieue a
aoa?iaaiac?” Oaea?ai? O.A. aeeiioaaeanue a ?aieao aea?aeaaii?
iaoeiai-oaoi?/ii? i?ia?aie “Caei?ia”y ethaeeie”, iai?yiie “Aoa?ineea?ic”
A?A 01008382 (AeIOI 17.0000.6292 ( 01.03.00/009-92) a eaai?aoi???
aenia?eiaioaeueii? ea?ae?ieia?? Oe?a?inueeiai iaoeiai-aeine?aeiiai
?inoeoooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeine?aeaeaiiy aoea ?ic?iaea
eiioeaioe?? iaoiaaiaco aoa?ineea?ico ia iniia? aecia/aiiy iaoai?ci?a
aeieeiaiiy iiaeeo?eiaaieo oi?i EI oa ?o ?ie? o oi?ioaaii? aoa?iaaiiiai
iioaioe?aeo ieacie ? noaiiaeaii? AOA, a oaeiae ?ic?iaea iiaiai iaoiaeo
aeiee?i?/ii? ae?aaiinoeee iayaiino? oa aeoeaiino? aoa?ineea?ioe/iiai
i?ioeano. Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaea/?:

1. Aecia/eoe iaea?eueo caeiiii??i? ci?ie iai?io EI e?ia? oa ?o
aca?iica’ycie c ae?aaeai?noth ? iioe?ai?noth AOA o oai?eo ?ON c
aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii.

2. Anoaiiaeoe ei?aeyoe?eio caeaaei?noue i?ae ai?noii caaaeueiiai ON
e?ia? oa nooiaiai ?? aoa?iaaiiino? o oai?eo ?ON c iaoith aecia/aiiy ?ie?
AOA o iaoiaaiac? aoa?ineea?ioe/iiai i?ioeano.

3. Aecia/eoe ?ieue ieneaeaoeaiiai no?ano a i?ioean? aoa?iaaiii?
iiaeeo?eaoe?? EI e?ia? oa i?aeaeuaii? ??aiy aoa?iaaiiino? ieacie o
oai?eo c o?ii?/iei ia?aa?aii ?ON, o oai?eo c aino?eie caiaeueieie
caoai?thaaiiyie, a oaeiae i?e aenia?eiaioaeueiiio iiaeaethaaii? aino?iai
caiaeueiiai i?ioeano.

4. Aecia/eoe ?ieue aeoeaaoe?? IOe o ?icaeoeo ieneaeaoeaiiai no?ano.

5. Anoaiiaeoe iaoai?cie ?icaeoeo AOA oa aoa?iaaiii? iiaeeo?eaoe?? EI
i?e iaaei??iiio iaaeoiaeaeaii? aeciaaiiiai ON o oaa?ei a oiiaao
oo?eiaiiy ia aoa?iaaii?e ae??o?.

6. Aecia/eoe iiaeeea?noue nainea?e?caoe?? nenoaie iaoaaie?cio EI aei
iaae?aoi??a caiaeaiiy oa noiaoe?? aeieeath/eo ii?ooaiue i?e iiaoi?iiio
a?aeoai?aii? caiaeueiiai i?ioeano.

7. Anoaiiaeoe i?e/eiii-iane?aeeiao caeaaei?noue i?ae aeoeaaoe??th IOe,
i?aeaeuaiiyi ?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a oa ii?ooaiiyi
iaoaaie?cio EI ye o oai?eo c ee?i?/ieie i?iyaaie aoa?ineea?ico ? o
ae?oae c aino?eie caiaeueieie caoai?thaaiiyie, oae ? i?e
aenia?eiaioaeueiiio iiaeaethaaii? aino?iai caiaeueiiai i?ioeano.

8. Anoaiiaeoe cia/ou?noue aioeieneaeaioii? oa?ai?? o ia?aeii?e oa
aoi?eii?e i?io?eaeoeoe? aoa?ineea?ico.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii, ui aaaeo/ei
iaoiaaiaoe/iei iaoai?ciii ?icaeoeo aoa?ineea?ico oa eiai ee?i?/ieo
i?iya?a ? c?inoaiiy aoa?iaaiiiai iioaioe?aeo e?ia?, coiiaeaia
iaeiie/aiiyi a i?e iiaeeo?eiaaieo EI. Iieacaii, ui AOA ia ?
oi?aa?naeueiei oaeoi?ii aoa?iaaiaco ? a?aei?/a?oueny o?eueee o 60-65%
oai?eo ?ON c aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii. Ia iniia?
a?aenooiino? i?yii? ei?aeyoe?eii? caeaaeiino? i?ae ai?noii caaaeueiiai
ON o e?ia? oa nooiaiai aoa?iaaiiino? ieacie aia?oa c?iaeaii aeniiaie i?i
oa, ui AOA ? a a?eueo?e i??? iaoiaaiaoe/iei, i?ae ao?ieia?/iei oaeoi?ii
aoa?ineea?ico ? iiaeiia ?icaeyaeaoenue ye ia?ea? aeniei? aeoeaiino?
iaoai?ci?a, ui coiiaeththoue ii?ooaiiy iaoaaie?cio EI. O ?iaio? aia?oa
anoaiiaeaii, ui aoa?iaaiee iioaioe?ae ieacie o oai?eo ?ON oa a oiiaao
aino?iai caiaeaiiy a cia/i?e i??? aecia/a?oueny iaeiie/aiiyi o e?ia?
iiaeeo?eiaaieo EI aiane?aeie ?icaeoeo ieneaeaoeaiiai no?ano oa
aeoeaaoe?? IIE. I?aeoaa?aeaeaii i?eiouaiiy, ui i?e/eiith aeieeiaiiy
ieneaeaoeaiiai no?ano ye i?e i?e?iaeiiio ?icaeoeo caiaeueiiai i?ioeano,
oae ? i?e eiai iiaeaethaaii? a oiiaao aenia?eiaioo ? aeoeaaoe?y
caiaeueieo ee?oei e?ia?. Aeiaaaeaii, ui iniiaith i?e/eiii-iane?aeeiai?
caeaaeiino? i?ae aeoeaaoe??th ee?oei e?ia? oa ii?ooaiiyie iai?io EI,
anoaiiaeaiith ye o oai?eo c ee?i?/ieie i?iyaaie aoa?ineea?ico oa o
ae?oae c aino?eie caiaeueieie caoai?thaaiiyie, oae ? i?e
aenia?eiaioaeueiiio iiaeaethaaii? aino?iai caiaeaiiy, ? i?aeaeuaiiy
?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a. Aia?oa iieacaii, ui i?e
iaaei??iiio iaaeoiaeaeaii? a i?aai?ci aeciaaiiai ON a oiiaao oo?eiaiiy
oaa?ei ia aoa?iaaii?e ae??o? AOA ?icaeaa?oueny ca i?eioeeiii ii?i/iiai
eiea c iine?aeiaiei aeeth/aiiyi ie?aieo iaoiaaiaoe/ieo iaoai?ci?a oa ?c
no?ae/anoei c?inoaiiyi ??aiy caaaeueiiai ON o e?ia?. I?e oeueiio AOA
aeieea? ia?aeiii, oiae? ye iiyaa aoa?iaaiieo aeanoeainoae ieacie ia?
aoi?eiiee oa?aeoa?; a oeeo oiiaao aeoeaaoe?y a?eueii?aaeeeaeueieo
?aaeoe?e ? oaeoi?ii, ui i?aeneeth? aoa?iaaiio iiaeeo?eaoe?th EI e?ia?.
A?aoiaoth/e ao?ieia?/io cia/ou?noue ieneaeaoeaieo i?ioean?a a
aoa?iaaii?e iiaeeo?eaoe?? EI e?ia? oa ?icaeoeo AOA, aeiaaaeaii, ui
aioeieneaeaioia oa?ai?y iiaeiia ?icaeyaeaoenue ye iaeaaaeeea?oee oeyo
ia?aeiii? oa aoi?eiii? i?io?eaeoeee aoa?ineea?ico, ieneaeaoeaiiai no?ano
oa iaeiie/aiiy o e?ia? aoa?iaaiieo EI.

Oai?aoe/ia oe?ii?noue. ?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy
aeicaieeee aecia/eoe iiaee iaoiaaiaoe/iee aa??aio ?icaeoeo AOA ye
iane?aeeo aoa?iaaiii? iiaeeo?eaoe?? EI oa anoaiiaeoe ?ieue
ieneaeaoeaiiai no?ano a ?acoeueoao? aeoeaaoe?? IOe e?ia? a yeino?
oaeoi?a, ui ?i?oe?th? ii?ooaiiy iai?io EI e?ia?, ?icaeoie AOA oa
eieaeueia ?aiiaeaethaaiiy noaeeiii? no?iee.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aecia/aiiy iaoai?ci?a, ui
?i?oe?ththoue aoa?iaaiio iiaeeo?eaoe?th EI oa ?icaeoie AOA, aeicaieeei
aecia/eoe ae?aaiinoe/i? e?eoa??? ii/aoeiaeo aoai?a aoa?iaaiaco, a oaeiae
anoaiiaeoe iiaeeeaino? iiia?aaeaeaiiy ?icaeoeo oeeo ci?i ca aeiiiiiaith
iai?aaeaiiai i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? IOe oa
?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a a e?ia?. Aeiaaaeaia
aeioe?euei?noue i?iaaaeaiiy aioeieneaeaioii? oa?ai?? aeey ia?aeiii? oa
aoi?eiii? i?io?eaeoeee ii?ooaiue iai?io EI e?ia?. ?ic?iaeaiee oa
ai?iaiaaiee o a?aeae?e? aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae
na?oey Oe?a?inueeiai IAe? ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea iaoiae
a?ioanooaaiiy aoa?iaaiiino? ieacie ca aeiiiiiaith eoeueoo?e II, yeee
iiaea ciaeoe canoinoaaiiy a ai?aeai?ieia?/ieo oa iaoeiaeo
aeine?aeaeaiiyo aeey aeyaeaiiy ?aii?o aeiee?i?/ieo oi?i ii?ooaiue iai?io
EI e?ia?.

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue, ui aeicaieeee noi?ioaaoe iiao
eiioeaioe?th iaoiaaiaco aoa?ineea?ico ia iniia? aecia/aiiy iaoai?ci?a
aeieeiaiiy iiaeeo?eiaaieo oi?i EI oa ?o ?ie? o oi?ioaaii? aoa?iaaiiiai
iioaioe?aeo ieacie ? noaiiaeaii? AOA, cai?iaaaeaeaii o eaeoe?eiee eo?n
eaoaae?e aini?oaeueii? oa?ai?? ?2 ? EOE Aoeiaeinueei? aea?aeaaii?
iaaee/ii? aeaaeai??.

?acoeueoaoe oa iniiai? iieiaeaiiy ?iaioe aeei?enoiaothoueny o ?iaio?
ea?ae?ieia?/ieo a?aeae?eaiue iaoeiai-aeine?aeiiai ?inoeoooo “Iaaeeoeeia
o?ainii?oo” i.Iaeana, Oeaio?aeueii? o?ainii?oii? ee?i?/ii? e?ea?i?
i.Ee?aa oa Aieeinueei? iaeanii? ee?i?/ii? e?ea?i?, i?i ui na?ae/aoue
aeoe ai?iaaaeaeaiiy.

Io?eiaii iiceoeaia ??oaiiy i?i aeaea/o iaoaioo ia aeiao?ae ? 98052453.

Iniaenoee aianie caeiaoaa/a iieyaa? o naiino?eiiio i?iaaaeaii?
aeine?aeaeaiue ii aecia/aiith ??aiy ooieoe?iiaeueii? aeoeaiino?
oee?eoethth/eo IOe, a?ioanooaaiith aoa?iaaiiino? e?ia?, aecia/aiith
noia?iiai ??aiy ia?ieneaeaoe?? e?i?ae?a ieacie oa noaio ??
aioeieneaeaioiiai iioaioe?aeo iaoiaeii OE, aecia/aiith aeoeaiino?
eaoaeace e?ia? oai?eo ?ON, ae?oae c aino?eie caiaeueieie caoai?thaaiiyie
i?aai?a aeeoaiiy, a oaeiae oaa?ei i?e aenia?eiaioaeueiiio iiaeaethaaii?
aino?iai caiaeueiiai i?ioeano oa ae?iaioa?ii? AOA. Aaoi?ii caiino?eii
a?aeoai?aia i?ea?iaeueia iiaeaeue aino?iai caiaeueiiai i?ioeano ca
aeiiiiiaith aioo??oiueiaaiiiai aaaaeaiiy e?ieeeai eaoaenieo i?e?inoa?
aai i??iaaiaeo, a oaeiae iiaeaeue ae?iaioa?ii? AOA o e?ieee?a oeyoii
o?eaaeiai oo?eiaiiy ia aoa?iaaii?e ae??o?. Ae?aaiic ?ON o oai?eo aoa
aa?eo?eiaaiee ca aeiiiiiaith i?iae c aeiciaaiei o?ce/iei iaaaioaaeaiiyi
ni?a?ia?oieeaie a?aeae?eo aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae
na?oey aai ei?iia?iaia?ia?ao??, i?iaaaeaii? ni?a?ia?oieeaie a?aeae?eaiiy
ei?iia?ii? oa ?aioaai-aiaeiaaneoey?ii? o??o?a??. *anoeiai e?i?aeiee
niaeo? e?ia? oai?eo ?ON aeine?aeaeaii a eaai?aoi??? ee?i?/ii? a?io?i??,
ii?oieia?/iee eiio?ieue no?oeoo?ieo ci?i no?iee ai?oe e?ieee?a aoa
i?iaaaeaiee aaaeo/ei iaoeiaei ni?a?ia?oieeii eaai?aoi??? iaoiii?oieia??
Oe?a?inueeiai IAe? ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea e.i.i.
I.A.Na?a??iei. Aaoi?ii iniaenoi i?iaaaeai? i?aeaioiaea ia?aeiieo aeaieo
aeey ia?iaee IAII, ia?aeiiee iieniaee oa ii??aiyeueiee noaoenoe/iee
aiae?ce, ei?aeyoe?eiee aiae?c ?acoeueoao?a ia IAII. Aeniiaee
aeena?oaoe?eii? ?iaioe c?iaeai? aaoi?ii iniaenoi.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
iaaiai?ai? ia XIII c”?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa ?i.
?.I.Iaaeiaa (Oa?e?a,1990), ?anioae?eainuee?e iaoeia?e eiioa?aioe??
(Oa?e?a,1991), eiioa?aioe?? iaoio?c?ieia?a Oe?a?ie (Aei?i?iiao?ianuee,
1992), iaoeia?e eiioa?aioe?? “Iiaia a eeeie/aneie oa?iaeieiaee e
oa?iaeioa?aiee caaieaaaiee aioo?aiieo i?aaiia” (Oa?e?a, 1992), IO
c”?cae? ea?ae?ieia?a Oe?a?ie (Aei?i?iiao?ianuee, 1993),
?anioaeeeainuee?e iaoeia?e eiioa?aioe?? “Aeooaeueiua aii?inu iaoiaaiaca,
aeeaaiinoeee e ea/aiey aoa?ineea?ica e eoaie/aneie aieacie na?aeoea
(Oa?e?a, 1994), O I?aeia?iaeiiio eiia?an? ea?ae?ieia?a Oe?a?ie (Ee?a,
1997), OO Annual International Society for Heart Research Meeting
(Columbia, 1993), 4-th World Congress on Heart Failure (Jerusalem,1996),
5-th Alpe-Adria Nardiology Meeting in Austria (Graz,1997), 5-th World
Congress on Heart Failure (Washington,1997), O c”?cae? oa?aiaao?a
Oe?a?ie (Ee?a, 1998), ieaioi? i?aae?iiy iaoeiaiai oiaa?enoaa
ea?ae?ieia?a Oe?a?ie “Aoa?ineea?ic oa ?oai?/ia oai?iaa na?oey: no/ani?
aniaeoe i?io?eaeoeee, ae?aaiinoeee oa e?eoaaiiy” (Ee?a, 1998).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 18 aeo?iaeueieo
noaoae, c ieo — 5 aac ni?aaaoi??a, 20 oac o iaoa??aeao eiioa?aioe?e,
c”?cae?a, eiia?an?a.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, 3 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy,
aeniiae?a oa nieneo aeei?enoaieo aeaea?ae. ?iaioa aeeeaaeaia ia 311
noi??ieao iaoeiiieniiai oaenoo, ?ethno?iaaia 15 oaaeeoeyie ? 25
iaethieaie. A?ae?ia?ao?/iee iieaae/ee i?noeoue 452 aeaea?aea, c ieo 118
ee?eeeoeath.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Iaoa oa caaea/? aeaii? ?iaioe ae??ooaaeenue oeyoii eiiieaeniiai
ianoaaeaiiy oai?eo ?ON c aa?eo?eiaaiei ei?iia?iei aoa?ineea?icii, ae?oae
c aino?eie caiaeueieie caoai?thaaiiyie, a oaeiae oeyoii i?iaaaeaiiy
a?aeiia?aeieo aeine?aeaeaiue i?e aenia?eiaioaeueiiio iiaeaethaaii?
aino?iai caiaeueiiai i?ioeano oa ae?iaioa?ii? AOA.

Aeine?aeaeaiiy i?iaaaeaii ia 127 iaoe??ioao c ?ON (/ieia?ee o
a?oe? a?ae 32 aei 63 ?ie?a), ui ciaoiaeeeenue ia e?eoaaii? o
a?aeae?eaii? aoa?ineea?ico oa o?ii?/ii? ?oai?/ii? oai?iae na?oey
Oe?a?inueeiai IAe? ea?ae?ieia??. Ae?aaiic ?ON aoa aa?eo?eiaaiee ca
aeiiiiiaith ei?iia?iaia?ia?ao?? aai i?iae c aeiciaaiei o?ce/iei
iaaaioaaeaiiyi. C a?oie ianoaaeaieo aeeeth/aeenue oai?? ?c noiooi?ie
o?ii?/ieie caoai?thaaiiyie aioo??oi?o i?aai?a oa iaaeinoaoi?noth
e?iaiia?ao (IE IIA-III). Eiio?ieueio a?oio neeaee 15 i?aeoe/ii caei?iaeo
in?a /ieia?/i? noao? oaei? ae a?eiai? eaoaai???, ye ? a aeine?aei?e
a?oi?.

Aeine?aeaeoaaeenue 15 ae?oae o a?oe? a?ae 1,5 aei 8 ?ie?a ia aenio?
?icaeoeo aino?iai caiaeueiiai caoai?thaaiiy i?aai?a aeeoaiiy
?ioaeoe?eii? i?e?iaee aac iciae ii?ooaiue e?i?aeiiai iai?io a aiaiiac?,
a oaeiae aeiaeaoeiai 5 oai?eo, ui i?ieoee eo?n i?ioecaiaeueii? oa?ai??
i?ney ii?iae?caoe?? oaiia?aoo?e o?ea oa cieeiaiiy ia’?eoeaieo iciae
caoai?thaaiiy.

Ae?iaioa?io AOA a?aeoai?thaaee o 22 e?ie?a oeyoii ?o oo?eiaiiy ia
i?ioyc? 8 oeaei?a ia aoa?iaaii?e ae??o? ?c ?ic?aooieo 0,2 a ON ia 1 ea
aaae oaa?eie. Aino?ee caiaeueiee i?ioean a?aeoai?thaaee ia 12 caei?iaeo
e?ieyo, yeeo oo?eioaaee ia noaiaea?oi?e ae??o?, oeyoii
aioo??oiueiaaiiiai aaaaeaiiy 1,6 ie 2,5% noniaic?? eaoaenieo i?e?inoa? 3
?ace /a?ac aeaiue; ie?aio a?oio neeaee 6 oaa?ei, yeei i?e?inoa?e
aaiaeeee iaeii?aciai a aiaeia?/i?e aeic?. 12 e?ieyi ia i?ioyc? 2-o
oeaei?a aei a?aeoai?aiiy aino?iai caiaeueiiai neiae?iio oa i?ae /an
anueiai aenia?eiaioo i?iaiaeeee i?io?eaeoe/io aioeieneaeaioio oa?ai?th
(eiiieaen aee?i- oa aiaei?ic/eiieo aioeieneaeaioieo a?oai?i?a —
anei?a?iiai? eeneioe 100 ia/ea aaae oa oieioa?ieo aoeaoaoo 33 ia/ea aaae
a aeaiue). O ae?oa?e na??? aeine?ae?a, ui oaeiae aeeth/aea 12 oaa?ei,
aeey iiaeaethaaiiy aino?iai caiaeaiiy canoiniaoany i??iaaiae ii 10 IIAe
ii aiaeia?/i?e noai?.

Iieacieee iai?io e?i?ae?a aeeth/aee aecia/aiiy ??aiy caaaeueiiai ON, OA
oa EIAU oa?iaioaoeaiei iaoiaeii ia e?i?aeiiio aaoiaiae?caoi??
“Technicon”. E?euee?noue iiaeeo?eiaaieo EI o ne?iaaooe? e?ia? aecia/aee
?c aeei?enoaiiyi eoeueoo?e II (Oa?oia A.A.,1990). Aeey aeae?eaiiy IOe
e?ia? aeei?enoiaoaaee iaoiae oeaio?eooaoaaiiy o a?aae??io? u?eueiino? ii
Recalde (1984). Aecia/aee ai?no ON o oee?eoethth/eo IOe oa ?o
caeaoi?noue iiaeeiaoe EI e?ia? i?e aeiaeaoeia?e noeioeyoe??, aeeeeeai?e
aeae?eaiiyi oa eoeueoeaoaaiiyi, ui aeicaieeei noaeeoe i?i i?eoiaaio
?aaeoeai?noue IOe. Ai?no ON o eoeueoo?? ee?oei oa ??aaiue caaaeueiiai ON
o ieaci? e?ia? aecia/aee ca iaoiaeii ?eueea (1987), ai?no ee?oeiiiai
a?eea — ca iaoiaeii Eio?? (1991). A yeino? iieaciee?a aeoeaiino? IIE o
IOe aeei?enoiaoaaee aioo??oiueiee?oeiiee ai?no IAeA (Eieaniaa
I.A.,1984). Nooi?iue aeoeaaoe?? oee?eoethth/eo IOe ioe?ithaaee ii
oaaioeeoa?i?e aeoeaiino?, yeo aecia/aee noaiaea?oiei iaoiaeii ca
aeiiiiiaith i?e?inoa? eaoaeno (Iioaiiaa N.A.,1977), a oaeiae ii
caeaoiino? i?iaeoeoaaoe ieneae acioo (Eooaeianeee I.N.,1971). Ia?aa?a
a?eueii?aaeeeaeueieo ?aaeoe?e a ieaci? e?ia? eiio?iethaaee ca noia?iei
ai?noii a?ae?iia?aeen?a e?i?ae?a (Aaa?eeia A.A.,1987), AeE (Asakawa T.
et al., 1980) oa IAeA, yeee aecia/aee c aeei?enoaiiyi o?iaa?a?oo?iai?
eeneioe (Asakawa T. et al., 1980). Aeey aecia/aiiy ?ioaa?aeueii?
oa?aeoa?enoeee ia?aa?ao a?eueii?aaeeeaeueieo ?aaeoe?e oa noaio
aioeieneaeaioii? nenoaie e?ia? aeei?enoiaoaaee iaoiae OE (Na?e?c
ss.?.,1988), a oaeiae aeoeai?noue eaoaeace e?ia? (Ei?iethe I.A.,1988,
Aeinii ?., 1991).

Ii?oieia?/i? aeine?aeaeaiiy no?oeoo?ieo ci?i no?iee ai?oe
i?iaiaeeee ?c aeei?enoaiiyi noaiaea?oieo iaoiaeee.

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe

O ianoaaeaieo oai?eo niinoa??aaeenue cia/i? ii?ooaiiy iai?io EI o
aeaeyae? ca?eueoaiiy ai?noo caaaeueiiai ON a na?aaeiueiio aei 6,27+0,20
iI/e, ui ia 21% (?<0,01) ia?aaeuoaaei ??aaiue ON o e?ia? iaoe??io?a eiio?ieueii? a?oie. I?ioa, AOA ia iaea caeiiii??iiai oa?aeoa?o ? a?aei?/aeanue o?eueee o 95 ?c 127 iaoe??io?a, oiae? ye o 25% oai?eo ai?no ON aoa o iaaeao ii?ie aai iaa?oue ieae/a ia? (a na?aaeiueiio 4,36+0,11 iI/e). ?icaeoie AOA aoa iia’ycaiee ia?o ca ana ?c ca?eueoaiiyi ai?noo ON EIIU aei 4,70+0,26 iI/e, ui ia 53% ia?aaeuoaaei eiio?ieueia cia/aiiy (?<0,05). ??ai? ON EIAeIU oa ON EIAU aoee o iaaeao ii?ie. A ?acoeueoao? cia/aiiy eiao?oe??ioo aoa?iaaiiino? (4,54+0,29) ia 51% ia?aaeuoaaei eiio?ieueia (?<0,05), a eiao?oe??io iiaeeo?eaoe?? ca?eueoeany ia 77% o ii??aiyii? c eiio?ieai - aei 4,78+0,20 (?<0,001); i?ioa oe? c?ooaiiy oaeiae ia iaee caeiiii??iiai oa?aeoa?o ? aoee a?aei?/ai? o 70-75% oai?eo. A oie aea /an i?aeoe/ii o an?o ianoaaeaieo oai?eo a?aei?/aeinue c?inoaiiy aoa?iaaiiino? e?ia?, ? ai?no ON a II i?ney ?ieoaaoe?? c ieaciith ca?eueoeany o na?aaeiueiio aei 244,91+7,09 iea/ia a?eea, ui ia?aaeuoaaei ia 142% aiaeia?/iee iieaciee o eiio?ieuei?e a?oi? (?<0,001). I?e oeueiio ei?aeyoe?eiee ca’ycie i?ae ??aiai ON oa iieacieeii aoa?iaaii?no? e?ia? aoa a?aenooi?e, ui na?ae/eei i?i neeaaeiee oa?aeoa? aca?iia?aeiinei i?ae ieie. Oaeiae i?aeoe/ii o an?o oai?eo aoea a?aei?/aia iayai?noue ae?aaeaiiai ieneaeaoeaiiai no?ano, i?i ui na?ae/eei ca?eueoaiiy iieaciee?a NOE, Ei oa Imax ?OE a na?aaeiueiio a?aeiia?aeii ia 109, 219 oa 72% a?aeiinii eiio?ieueieo cia/aiue (?<0,001). Na?ae/aiiyi aeoeaaoe?? a?eueii?aaeeeaeueieo ?aaeoe?e oa iieacieeii iayaiino? iiaeeo?eiaaieo EI o e?ia? aoei c?inoaiiy eiioeaio?aoe?? a i?e IAeA a na?aaeiueiio ia 111% (aei 5,04+0,22 ieI/e, ?<0,001). Ia?aeaeueii oeueiio a?aei?/aeinue nionoioaiiy aioeieneaeaioieo iiaeeeainoae ieacie, ui i?iyaeyeiny cieaeaiiyi aeoeaiino? eaoaeace ia 56% (?<0,001), ca?eueoaiiyi ia 213% (?<0,001) Imin ?OE oa ciaioaiiyi ia 23% oaeaeeino? aan?iiy oaeaeeiai niaeaoo ?OE (?<0,01). I?ioa, iacaaaeath/e ia caeiiii??iee oa?aeoa? ieneaeaoeaiiai no?ano oa c?inoaiiy aoa?iaaiiino? ieacie, i?ae ieie ia aoei a?aei?/aii ei?aeyoe?eii? caeaaeiino?, ye ? i?ae eiaeiei c oeeo iieaciee?a oa ai?noii ON e?ia?. Oea na?ae/eoue i?i aaaaoioaeoi?i?noue i?ioeano iiaeeo?eaoe?? EI oa ia?aaeaa/a? iayai?noue ? ?ioeo, e??i a?eueii?aaeeeaeueiiai ieeneaiiy EIIU, iaoai?ci?a i?aeaeuaiiy aoa?iaaiiino? ieacie. A?aeiia?aeii aeaiei e?oa?aoo?e, oea ia?o ca ana iiaea aooe iia’ycaia ?c c?inoaiiyi ai?noo o e?ia? b-EIAeIU - EI, ia?acaaaa/aieo OA aai ao??aie ON. Ia oea aeaco? oaeiae a?aei?/aia iaie a??ia?aeia ca?eueoaiiy ia 30% (a na?aaeiueiio aei 2,60+0,22 iI/e, ?<0,05) ai?noo OA o ieaci?. I?ioa nai? oe? ci?ie a ??ai?e i??? ia iiaee aooe aieiaiith i?e/eiith i?aeaeuaiiy aoa?iaaiiiai iioaioe?aeo e?ia?, ai aiie ia iineee caeiiii??iiai oa?aeoa?o ? aoee a?aei?/ai? o?eueee i?eaeecii o iieiaeie (66 ?c 127) ianoaaeaieo iaoe??io?a. Iayai?noue ieneaeaoeaiiai no?ano o oai?eo ?ON caeiiii??ii ii?aeioaaeanue ?c aeoeaaoe??th IOe. Oae, ai?no a ieo IAeA neeaaeaa 5,27+0,57 ieI/ia a?eea ? aoa i?aeaeuaiee ia 251% o ii??aiyii? c eiio?ieueiith a?oiith (?< 0,001). Caeaoi?noue IOe oai?eo ieenethaaoe aaiiaeia?i aaiie?ciaaieo a?eo?ioeeo?a aei iaoaaiiaeia?io, ca yeith noaeeee i?i i?iaeoeoe?th NO, ia?aaeuoaaea eiio?ieueia cia/aiiy a?eueo i?ae o 5 ?ac?a (?<0,01). Ia?aeaeueii ca?eueooaaeanue ? oaaioeeoa?ia aeoeai?noue IOe: aaee/eie IO ia 88%, a O* - ia 59% ia?aaeuoaaee eiio?ieuei? (?<0,001). Ai?no ON a IOe o ianoaaeaieo oai?eo aoa i?aeaeuaiee ia 57% (?<0,001) ? aeinyaaa 132,69+5,59 iea/ia a?eea. Caoiieaiiy EI IOe oai?eo i?ney ?ieoaaoe?? ?c na?aaeiaeuai, ui i?noeei 30% aeanii? ieacie, ia?aaeuoaaei ia 116% aaee/eio aeaii? ?aaeoe?? o caei?iaeo aeiii??a (?<0,001). I?eoiaaia ?aaeoeai?noue IOe, i?i yeo noaeeee ii ?o caeaoiino? iaeiie/oaaoe EI i?e aeiaeaoeia?e noeioeyoe??, aeeeeeai?e aeae?eaiiyi oa eoeueoeaoaaiiyi, oaeiae cia/ii (ia 243%) ia?aaeuoaaea cia/aiiy aiaeia?/ii? ?aaeoe?? o eiio?ie? (?<0,001). Aeoeaaoe?y IOe iaea caeiiii??iee oa?aeoa? ? aeyaeyeanue i?aeoe/ii o an?o ianoaaeaieo oai?eo. A oie aea /an, a?aenooi?noue i?yii? ei?aeyoe?eii? caeaaeiino? i?ae ??aiai aeoeaiino? IOe, ?ioaineai?noth IIE e?ia?, nooiaiai aoa?iaaiiino? ieacie oa ae?aaeai?noth AOA na?ae/eoue i?i o/anoue ? ?ioeo ee?oei e?ia? o ?i?oe?aoe?? ieneaeaoeaiiai no?ano c iiaeaeueoei ?icaeoeii ii?ooaiue iai?io EI. Oaeei /eiii, noeoii?noue io?eiaieo aeaieo na?ae/eoue i?i oa, ui oi?aa?naeueieie iaoiaaiaoe/ieie oaeoi?aie aoa?ineea?ico ? ?icaeoie ieneaeaoeaiiai no?ano, aeoeaaoe?y oee?eoethth/eo IOe oa c?inoaiiy aoa?iaaiiino? ieacie. Iacaaaeath/e ia a??ia?aeia i?aeaeuaiiy ai?noo caaaeueiiai ON e?ia? o ianoaaeaieo oai?eo, oe? ci?ie ia iineee caeiiii??iiai oa?aeoa?o, ui aeicaiey? ?icaeyaeaoe ?icaeoie AOA ye aoi?eiiee i?ioean o aoa?iaaiac?. I?i oea na?ae/aoue oaeiae ?acoeueoaoe ii??aiyeueiiai aiae?co ci?i iieaciee?a aeoeaiino? IOe, ?ioaineaiino? ieneaeaoeaiiai no?ano oa ??aiy aoa?iaaiiino? ieacie, yeee iieacaa, ui aiie aoee a ??ai?e i??? ae?aaeai? o oai?eo ye c ii?iaeueiei ??aiai ON o e?ia? (n=32), oae ? c AOA (n=95). Iieacieee noaio i?i- oa aioeieneaeaioiiai iioaioe?aeo e?ia? a iaio i?aea?oiao oai?eo oaeiae i?aeoe/ii ia a?ae??ciyeenue iaeei a?ae iaeiiai, oa a?ae na?aaei?o cia/aiue a oe?eiio ii a?oi?. Aiaeia?/iei /eiii ia aoei a?aei?/aii a??ia?aeieo a?aei?iiinoae i?ae oa?aeoa?ii ci?i aeine?aeaeoaaieo iieaciee?a i?e ie?aiiio aiae?c? o i?aea?oiao oai?eo c ??cei oa iii??ii ae?aaeaiith aeoeaaoe??th IOe e?ia?, c aenieith oa iii??iith ?ioaineo?eaoe??th a?eueii?aaeeeaeueiiai ieeneaiiy EI, c ??cei oa iii??ii i?aeaeuaiei ??aiai aoa?iaaiiino? ieacie. Ci?ie iieaciee?a aeoeaiino? IOe e?ia?, ?ioaineaiino? IIE oa ii?ooaiue iai?io EI e?ia? oaeiae a??ia?aeii ia a?ae??ciyeenue o i?aea?oiao oai?eo c i?aeaeuaiei oa ii?iaeueiei ai?noii OA o ieaci?. I?iaaaeaiee ia?iee ei?aeyoe?eiee aiae?c ia anoaiiaea caeaaeiino? i?ae aoa?iaaii?noth ieacie oa ai?noii a i?e OA. E??i oiai, o oai?eo c ae?aaeaiith AOA niinoa??aaeinue ? nooo?aa i?aeaeuaiiy o e?ia? ??aiae ye caaaeueiiai ON (ia 22%, ?<0,05), oae ? ON EIIU (ia 27%, ?<0,05), aeacoth/e ia oa, ui c?inoaiiy aoa?iaaiiino? ieacie aoei ?acoeueoaoii niieo/aiiai i?ioeano ii?ooaiue iai?io EI, aaaaoeo ye OA, oae ? ON. Oaeei /eiii, a?aenooi?noue a??ia?aeieo ei?aeyoe?eieo caeaaeiinoae i?ae aeoeai?noth IOe, ?ioaineai?noth ieneaeaoeaiiai no?ano, nooiaiai aoa?iaaiiino? e?ia? oa ae?aaeai?noth AOA na?ae/eoue i?i aaaaoioaeoi?i?noue aoa?ineea?ioe/iiai i?ioeano oa i?i ?nioaaiiy neeaaeieo i?e/eii-iane?aeeiaeo a?aeiinei i?ae oaeoi?aie, ui eaaeaoue a eiai iniia?. *a?ac oea inoaoi/ia ae??oaiiy ieoaiiy i?i iaoai?cie ?icaeoeo aoa?iaaiiino? ieacie ia iniia? o?eueee ee?i?/ieo niinoa?aaeaiue iaa?yae /e oyaey?oueny iiaeeeaei. Oea iineoaeeei iniiaith aeey aeine?aeaeaiiy caeaaeiino? i?ae ?ioaineai?noth a?eueii?aaeeeaeueieo i?ioean?a, oa?aeoa?ii ii?ooaiue iaoaaie?cio EI e?ia? oa ?? aoa?iaaii?noth a oiiaao, ui aeeeth/athoue ia?aeii? ii?ooaiiy iai?io EI, oiaoi i?e ia?aeii?e aea??eia?e aeoeaaoe?? IOe. Aeai?e iinoaiiaoe? caaea/? iaea?eueo iiaii a?aeiia?aeaee oiiae, ui aeieeaee i?e aaia?ae?ciaaiiio caiaeueiiio neiae?ii? ?ioaeoe?eii? i?e?iaee a iaae?ao?e/i?e i?aeoeoe? oa i?e aenia?eiaioaeueiiio a?aeoai?aii? aino?iai nenoaiiiai caiaeueiiai i?ioeano. ?acoeueoaoe aeine?aeaeaiue, i?iaaaeaieo ia oai?eo - ae?oyo o a?oe? a?ae 2 aei 8 ?ie?a ia aenio? aino?iai caiaeaiiy, na?ae/eee i?i cia/io aeoeaaoe?th IOe. Oae, eiioeaio?aoe?y a ieo IAeA aei??aithaaea 7,6+1,3 ieI/ia a?eea, ui a 5,1 ?aca (?<0,01) ia?aaeuoaaei eiio?ieueio aaee/eio, a caeaoi?noue aea?eueithaaoe ieneae acioo - o 2-2,5 ?ace. ?noioii ca?eueoeeenue iieacieee oaaioeeoa?ii? aeoeaiino? IOe: IO ia 62%, a O* ia 100% (?<0,05). Ai?no ON o IOe noaiiaea o na?aaeiueiio 165,95+12,60 iea/ia a?eea, ui ia?aaeuoaaei iaeaea a 2 ?ace eiai aaee/eio o caei?iaeo aeiii??a (?< 0,001), a ?aaeoeai?noue IOe aoea i?aeaeuaia a ii??aiyii? c eiio?ieueiei cia/aiiyi a?eueo i?ae o 3 ?ace (?< 0,001). A ?acoeueoao? ae?aaeai?noue ?aaeoe?? aeiaeaoeiaiai caoiieaiiy EI ?c na?aaeiaeua IOe o i?ioean? ?o eoeueoeaoaaiiy aoea a na?aaeiueiio o 5,2 ?aca a?eueoa a ii??aiyii? c eiio?ieai (?<0,001). Ia?aeaeueii c?inoaea ?ioaineai?noue a?eueii?aaeeeaeueieo i?ioean?a oa ia?ieneaeaoe?? EI: cia/aiiy NOE ieacie a 2,3 ?ace (?<0,001), a Ai oa I max ?OE ia 220% oa 35% (?<0,001) a?aeiia?aeii ia?aaeuoaaee eiio?ieuei?. Eiioeaio?aoe?y IAeA o ieaci? c?inea ia 57% (?<0,05) ? aeinyaea 3,6+0,4 ieI/e; oiae? ye aaee/eia Imin ?OE ca?eueoeeanue ia 264%, aeoeai?noue eaoaeace ieacie aoea i?eai?/aia o 2,6 ?ace (?<0,001), a oaeaee?noue aan?iiy niaeaoo ?OE ciaiueoeeanue ia 18% (?< 0,05), ui o noeoiiino? na?ae/eei i?i nionoioaiiy aioeieneaeaioiiai iioaioe?aeo ne?iaaoee e?ia?. Ia?iee ei?aeyoe?eiee aiae?c anoaiiaea iayai?noue i?yiiai ca’yceo (r=0,51, ?<0,05) i?ae ci?iaie eiioeaio?aoe?? IAeA o IOe oa Ei ?OE, ui i?aeoaa?aeaeo? ?i?oe?thth/o ?ieue oee?eoethth/eo IOe a aeoeaaoe?? IIE e?ia?. Icia/ai? ci?ie noi?iaiaeaeoaaeenue ii?ooaiiyie iai?io EI oa iiyaith o e?ia? ?o iiaeeo?eiaaieo aoa?iaaiieo oi?i. Oae, ??aaiue ON o II i?ney ?ieoaaoe?? c ieaciith oai?eo aeinyaaa o na?aaeiueiio 327,75+20,10 iea/ia a?eea, ui a?aeiia?aeaei ca?eueoaiiio i?eaeecii o 3 ?ace caoiieaiith EI o ii??aiyii? c iipiith (?<0,001). Iayai?noue /?oei? caeaaeiino? i?ae ii?ooaiiyie iai?io EI o e?ia? oa ?i?oe?aoe??th IIE a ?acoeueoao? aeoeaaoe?? IOe ia aenio? caiaeueiiai i?ioeano i?aeoaa?aeaeoaaeanue ?acoeueoaoaie ia?iiai ei?aeyoe?eiiai aiae?co, yeee anoaiiaea iayai?noue i?yii? caeaaeiino? (r= 0,51, P< <0,05) i?ae eiioeaio?aoe??th IAeA o IOe oa ai?noii iiaeeo?eiaaieo EI o e?ia?, a oaeiae i?ae ?ioaineai?noth IIE o e?ia?, ui aecia/aeanue ii aaee/ei? Ei ?OE, oa ai?noii ON o II (r=0,57, P<0,05). ?icaeoie aino?iai caiaeueiiai i?ioeano i?eaiaeea aei iii??iiai (o na?aaeiueiio ia 50% a?aeiinii a?eiai? ii?ie), aea a??ia?aeiiai i?aeaeuaiiy ??aiy ON e?ia?, yeee aeinyaaa 4,78+0,50 iI/e (?<0,05). Ia?iee ei?aeyoe?eiee aiae?c anoaiiaea iayai?noue aeoaea neeueiiai i?yiiai ca’yceo (r= 0,89, P<0,01) i?ae eiioeaio?aoe??th IAeA o IOe ye iieacieea ?o aeoeaiino? oa ai?noii ON o e?ia?, aeoaea neeueii? i?yii? caeaaeiino? (r=0,73, P<0,01) i?ae inoaii?i oa Ai ?OE, a oaeiae neeueiiai i?yiiai ca’yceo (r=0,56, P<0,05) i?ae ??aiai iiaeeo?eiaaieo EI oa ai?noii ON o e?ia?. Oe? caeaaeiino? na?ae/aoue i?i ?i?oe?thth/o ?ieue IOe a aeoeaaoe?? IIE, ii?ooaii? iai?io EI oa ?icaeoeo AOA, a oaeiae i?i oa, ui ?acaeoie AOA ia? aoi?eiiee oa?aeoa? ii a?aeiioaiith aei c?inoaiiy aoa?iaaiiino? e?ia?. I?e ye?ni?e iaeii??aeiino? niinoa??aa?ieo ci?i ?o ae?aaeai?noue o ie?aieo oai?eo eieeaaeanue a cia/iiio ae?aiacii?, ui iiaei aooe coiiaeaia ??ciith ?ioaineai?noth aino?iai caiaeueiiai i?ioeano. O ca’yceo c oeei caeaaei?noue i?ae aeoeaaoe??th IOe, ?ioaineai?noth IIE oa oa?aeoa?ii ii?ooaiue iaoaaie?cio EI aoea i?iaiae?ciaaia a ie?aieo i?aea?oiao oai?eo, noi?iiaaieo ca i?eioeeiii ae?aaeaiino? ci?i ie?aieo iieaciee?a. ?acoeueoaoe i?iaaaeaiiai aiae?co na?ae/aoue i?i oa, ui a i?aea?oi? oai?eo c a?eueo ?ioaineaiith aeoeaaoe??th IOe (aioo??oiueiee?oeiiee ai?no IAeA ia?aaeuoaaa na?aaei? cia/aiiy ii a?oi? ia 55%) o ii??aiyii? c i?aea?oiith, aea ai?no IAeA o IOe ca?eueoeany ia 60% iaiueoa, i?ae o na?aaeiueiio ii a?oi?, a?aeaoaaeinue a??ia?aeii a?eueo ae?acia (ia 74%, ?<0,001) ca?eueoaiiy eiioeaio?aoe?? IAeA o ne?iaaooe?, ia 23% (?<0,05) a?eueoa c?inoaiiy ai?noo o e?ia? iiaeeo?eiaaieo EI; a?aei?/aany oaeiae ia 35% (?<0,05) a?eueoee i?e??no Ei ?OE oa ia 96% - a?eueo nooo?aa ca?eueoaiiy ai?noo caaaeueiiai ON o e?ia? (?<0,001). I?eaeecii oaeee aea oa?aeoa? caeaaeiino? a?aei?/aany ? i?e aeae?eaii? i?aea?oi ia iniia? ?ioaineaiino? aeoeaaoe?? IIE e?ia?. A i?aea?oi?, ui oa?aeoa?ecoaaeanue aenieeie iieacieeaie ?OE (A? c?inoaei ia 38% a?eueoa na?aaeiuei? aaee/eie ii a?oi?), ia 144% (?<0,001) aoa a?eueoa ??aaiue IAeA o IOe, ia 25% (?<0,01) ia?aaaaeaa ai?no o ieaci? iiaeeo?eiaaieo EI oa ia 171% (?<0,001) aoa aeuei ??aaiue o ieaci? caaaeueiiai ON. Aiaeia?/iei /eiii, o i?aea?oi? oai?eo c a?eueo nooo?aei c?inoaiiyi ai?noo o ieaci? iiaeeo?eiaaieo EI (ia 24% o ii??aiyii? ?c na?aaeiueith aaee/eiith o oe?eiio ii a?oi? oa ia 45% - c ??aiai o 2-e i?aea?oi?, ?<0,001) a??ia?aeii a?eueoa aoee aeoeaiaai? IOe (ia 60% a?eueoa ae??n aioo??oiueiee?oeiiee ai?no ON oa ia 141% - IAeA, ?<0,05), ia 32% a?eueo ?ioaineaiei aoei c?inoaiiy ?aaeoeaiino? IOe (?<0,05), ia 100% ia?aaeuoaaa i?e??no A? ieacie (?<0,001), ia 41% - ca?eueoaiiy ai?noo IAeA o ne?iaaooe? (?<0,01). A oe?e i?aea?oi? a??ia?aeii a?eueoei aoa ? ai?no caaaeueiiai ON o e?ia? (8,4+0,3 o ii??aiyii? c 2,6+0,2 iI/e o oai?eo 2-i? i?aea?oie, ?<0,001). Oaea ae caeiiii??i?noue caa??aaeanue i?e ii??aiyeueiiio aiae?c? oa?aeoa?o ci?i aeine?aeaeaieo iieaciee?a o oai?eo ?c iayai?noth oa a?aenooi?noth AOA. Cia/ia AOA (??aaiue ON o e?ia? ia 56% a?eueoa i?ae a na?aaeiueiio ii a?oi? oa ia 257% - i?ae o 2-e i?aea?oi?, ?<0,001) ?icaeaaeanue o oai?eo c a?eueo ?ioaineaiith aeoeaaoe??th IOe (ia 30% a?eueoa aioo??oiueiee?oeiiee ai?no ON oa ia 86% - IAeA, ?<0,05), c a?eueo ae?aaeaiith ?ioaineai?noth IIE e?ia? (aaee/eia A? a?eueoa ia 123%, Imax - ia 186%, Imin - ia 150%, ?<0,001), ?c a?eueoei ia 32% ai?noii o e?ia? iiaeeo?eiaaieo EI (?<0,001). Oaeei /eiii, ?icae?eueiee aiae?c aeaieo ii i?aea?oiao oai?eo c ??ciei nooiaiai ci?i ie?aieo iieaciee?a oaeiae i?aeoaa?aeaeo? aeniiaie i?i oa, ui o oai?eo a aino?o oaco caiaeueiiai i?ioeano niinoa??aa?oueny /?oea i?yia caeaaei?noue i?ae aeoeaaoe??th IOe, c?inoaiiyi ?ioaineaiino? ia?aeenieo i?ioean?a, aoa?iaaiiith iiaeeoe?eaoe??th EI oa i?e?inoii ??aiy caaaeueiiai ON o e?ia?. Oe? aeai? aeicaieeee c?iaeoe aeniiaie, ui nenoaiiee caiaeueiee neiae?ii /a?ac aeoeaaoe?th oee?eoethth/eo IOe oa iiaeaeueoee ?icaeoie o?eaaeiai ieneaeaoeaiiai no?ano i?eaiaeeoue aei c?inoaiiy aoa?iaaiiiai iioaioe?aeo e?ia? oa ? naiino?eiei ?, iiaeeeai, iaa?oue iaeiei ?c aaaeo/eo iaoiaaiaoe/ieo iaoai?ci?a aoa?ineea?ico. I?aeoaa?aeaeaiiyi oeueiai iieiaeaiiy aoee ?acoeueoaoe ianoaaeaiiy 5 oai?eo ae?oae i?ney eo?no i?ioecaiaeueii? oa?ai??, eiee niinoa??aaeinue cia/ia cieaeaiiy aeoeaiino? IOe, eiioeaio?aoe?y IAeA a yeeo ciaioeeanue ia 54% aei 3,46+0,40 ieI/ia a?eea (?<0,001), caeeoath/enue, ao?i, ia 130% a?eueoa ii?iaeueiiai cia/aiiy (?<0,01). Ai?no ON o IOe ? ?o ?aaeoeai?noue i?aeoe/ii ii?iae?coaaeenue, a??ia?aeii i?eai?/oaaeenue a?eueii?aaeeeaeuei? i?ioeane: aaee/eie NOE, Imin oa A? ?OE a??ia?aeii ciaioeeenue, i?ioa caeeoaeenue aeua ii?iaeueieo cia/aiue (?<0,001), oiae? ye aaee/eia Imax i?aeoe/ii ii?iae?coaaeanue. Iacaaaeath/e ia oea, a oaeiae ia cia/ia c?inoaiiy aeoeaiino? eaoaeace (o na?aaeiueiio ia 78%, ?<0.001), eiioeaio?aoe?y IAeA o ieaci? caeeoaeanue a??ia?aeii aeuith ii?iaeueiiai cia/aiiy (o na?aaeiueiio ia 67%, P< <0,001). Aoa?iaaii?noue ieacie oai?eo i?ney e?eoaaiiy iiaa?oaeanue aei ii?iaeueiiai ??aiy, i?ioa caaaeueiee ON o e?ia? i?aeoe/ii ia a?ae??ciyany a?ae oiai, yeee aoa a?aei?/aiee aei e?eoaaiiy. Ioaea, i?ioecaiaeueia oa?ai?y ?noioii cieaeoaaea aeoeai?noue IOe, ?ioaineai?noue IIE ? /anoeiai ii?iae?coaaea ai?no aoa?iaaiieo EI o e?ia?, ui ?icaeyaeaeinue ye iaaia i?aeoaa?aeaeaiiy ca’yceo ii?ooaiue iaoaaie?cio EI ?c caiaeueiei i?ioeanii. A oie aea /an, caa?aaeaiiy o?eaaeee /an i?ney e?eoaaiiy AOA oa ii?ooaiiai oa?aeoa?o caeaaeiino? i?ae noaiii IOe, ?ioaineai?noth IIE, aoa?iaaii?noth ieacie oa ai?noii caaaeueiiai ON e?ia? na?ae/eoue i?i iayai?noue ia oeueiio aoai? ?noioii a?aei?iieo i?e/eiii-iane?aeeiaeo aca?iia?aeiioaiue i?ae aeine?aeaeaieie yaeuaie. ?acoeueoaoe aeine?aeaeaiue, i?iaaaeaieo ia aenia?eiaioaeuei?e iiaeae? nenoaiii? caiaeueii? ?aaeoe??, yea aoea a?aeoai?aia oeyoii aioo??oiueiaaiiiai aaaaeaiiy e?ieyi eaoaenieo i?e?inoa?, iiai?noth i?aeoaa?aeeee aeai? ee?i?/ieo aeine?aeaeaiue. Ia?o ca ana, oaea ia i?ioyc? 1-ai oeaeiy a?aei?/aeanue cia/ia aeoeaaoe?y IOe, ui i?iyaeyeinue ca?eueoaiiyi o 4,8 ?ace eiioeaio?aoe?? a ieo IAeA (aei 2,40+0,31 ieI/ia a?eea, ?<0,001). Iaeneiaeueiue i?e??no oeueiai iieacieea aei 4,66+0,34 ieI/ia a?eea, ui o 9,3 ?ace ia?aaeuoaaa ii/aoeiaa cia/aiiy (?<0,001), a?aei?/aany /a?ac 2-3 oeaei? i?ney ii/aoeo aenia?eiaioo. *a?ac 2 oeaei? i?ney aaaaeaiiy eaoaeno i?iaeoeoe?y ieneaeo acioo aoea iineeaia o na?aaeiueiio a 4,25 ?ace ? aeinyaaea iaeneiaeueiiai cia/aiiy a e?ioe? 4-ai oeaeiy, eiee aiia o 17 ?ac?a ia?aaeuoaaea aeo?aeio. Ai?no ON o IOe /a?ac 1 oeaeaeaiue i?ney ao?o/aiiy c??n iaeaea o 2 ?ace (a?ae 44,97+1,24 aei 84,80+6,75 iea/ia a?eea, ?<0,001), a iaeneiaeueii - o 4,2 ?ace (aei 190,41+ +10,91 iea/ia a?eea, ?<0,01) - /a?ac 4-5 oeaei?a i?ney aaaaeaiiy eaoaeno. Ia?aeaeueii c oeei a?aei?/aeinue ? ?noioia c?inoaiiy i?eoiaaii? ?aaeoeaiino? IOe - o 4,7 ?ace /a?ac 1-1,5 oeaei? i?ney ao?o/aiiy (?<0,001), a ?acoeueoao? /iai aaee/eia ?aaeoe?? caoiieaiiy EI IOe i?ney eoeueoeaoaaiiy aoea o 77,7 ?ac ca?eueoaia o ii??aiyii? c ii/aoeiaith. Aeoeaaoe?y IOe ii?aeioaaeanue ?c ?icaeoeii ieneaeaoeaiiai no?ano: o e?ioe? 2-4-ai oeaei?a aaee/eie NOE, Ai oa Imax ia 46, 136 oa 164% a?aeiia?aeii ia?aaeuoaaee ii/aoeia? cia/aiiy (?<0,01). Eiioeaio?aoe?y IAeA o ieaci? a e?ioe? 1 oeaeiy ca?eueoeeanue ia 64% (a?ae 0,81+0,05 aei 1,33+0,22 ieI/e, P< <0,05), a /a?ac 3 oeaei? ia?aaeuoaaea ii/aoeiao o 3,5 ?ace (P<0,001). Oe? ci?ie a?aeaoaaeenue ia oii? ?noioiiai aeniaaeaiiy aioeieneaeaioiiai iioaioe?aeo e?ia?, i?i ui na?ae/eei i?ia?anoth/a c 1-ai oeaeiy c?inoaiiy aiie?ooaee Imin ?OE, yea iaeneiaeueii ia 48% ia?aaeuoaaea ii/aoeiao (?<0,05), oa cieaeaiiy aeoeaiino? eaoaeace e?ia? /a?ac 3 oeaei? aei ??aiy 40% a?ae ii/aoeiaiai cia/aiiy (?<0,001). Ia?aeaeueii a?aeaoaaeinue c?inoaiiy aoa?iaaiiino? ieacie: /a?ac 1 oeaeaeaiue caoiieaiiy EI II ca?eueoeeinue iaeaea o 5 ?ac?a (aei 193,57+10,54 iea/ia a?eea (?<0,001), a a e?ioe? 4-ai oeaeiy - o 10 ?ac?a, aei??aithth/e 393,62+15,30 iea/ia a?eea (?<0,001). Oea noi?iaiaeaeoaaeinue aeaui oiia?eueiaiei c?inoaiiyi ??aiy ON o ieaci?, ? aaea /a?ac 1 oeaeaeaiue a?i aoa i?aeaeuaiee ia 23,6% (?>0,05). AOA
iaaoaaea caeiiii??iiai oa?aeoa?o /a?ac 4-5 oeaei?a, eiee ai?no ON aoa
ca?eueoaiee o 8,7 ?ac?a (a?ae 1,44+0,18 aei 12,46+1,12 iI/e, ?<0,001). I?aeoe/ii aeey an?o aeine?aeaeaieo iieaciee?a aoea oa?aeoa?ia a?aenooi?noue iiaii? ii?iae?caoe?? iaa?oue /a?ac 7 oeaei?a i?ney a?aeoai?aiiy aino?iai caiaeueiiai i?ioeano, ui na?ae/eoue i?i caoyaeiee oa?aeoa? aeieeath/eo ?aaeoe?e. Oea noaei iniiaith aeey i?eiouaiiy i?i iiaeeea?noue ?icaeoeo nainea?e?caoe?? i?aai?cio aei ae?? iaae?aoi??a caiaeaiiy, o ?acoeueoao? /iai iiaoi?ia ao?o/aiiy iiaei i?eaiaeeoe aei aeieeiaiiy a?eueo ?ioaineaieo c?ooaiue. C iaoith ia?aa??ee oeueiai i?eiouaiiy /a?ac 7 oeaei?a i?ney ia?oiai ao?o/aiiy i?iaiaeeee iiaoi?ia iaeii?aciaa aaaaeaiiy eaoaenieo i?e?inoa? ? iii?oi?oaaee o aeeiai?oe? oa?aeoa? aeieeath/eo ci?i. Anoaiiaeaii, ui iiaoi?ia ao?o/aiiy noi?iaiaeaeoaaeinue a?eueo oaeaeeei ? cia/iei i?aeaeuaiiyi aeoeaiino? IOe. Aaea /a?ac 1-2 aei? ai?no a ieo IAeA ae??n aei 3,96+0,49 ieI/ia a?eea - o 7,9 ?ace o ii??aiyii? c ii?iith (?<0,001), o 2,8 ?ace (?<0,001) - c ii/aoeiaith aaee/eiith (aei iiaoi?iiai aaaaeaiiy) ? i?aeoe/ii ia a?ae??ciyany a?ae iaeneiaeueiiai cia/aiiy, a?aei?/aiiai /a?ac 2-3 oeaei? i?ney o?e?aciaiai aaaaeaiiy eaoaeno. Aaea /a?ac 3-5 aei?a i?ney iiaoi?iiai aaaaeaiiy eaoaeno ai?no ON o IOe e?ia?, a oaeiae o IOe i?ney eoeueoeaoaaiiy o 3,5 ?ace ia?aaeuoaaa ii?iaeuei? cia/aiiy (?< <0,001) ? aoa iaeaea ia ??ai? iaeneiaeueiiai, aecia/aiiai /a?ac 4-5 oeaei?a i?ney ia?oiai a?eueo ?ioaineaiiai ao?o/aiiy, ui na?ae/eoue i?i cia/ii a?eueo ae?aaeaia ia?inoaiiy i?eoiaaii? ?aaeoeaiino? IOe i?e iiaoi?iiio ao?o/aii?. A oie aea /an, a oeeo oiiaao caa??aaany ae?aaeaiee ia?aeae?ci i?ae i?aeaeuaiiyi aeoeaiino? IOe oa ?ioaineai?noth a?eueii?aaeeeaeueieo i?ioean?a o e?ia?. A?aei?/aeinue a?eueo oaeaeea ia?inoaiiy iieaciee?a NOE oa ?OE o ii??aiyii? ?c aeeiai?eith ?aaeoe?? ia ia?oa o?e?aciaa aaaaeaiiy eaoaeno. Oae, aaea /a?ac 1-2 aei? iieacieee NOE oa Ai ?OE ia 80% ia?aaeuoaaee ye ii/aoeiaa, oae ? ii?iaeueia cia/aiiy (?<0,001) ? a?aeiia?aeii ia 10 oa ia 23% aoee a?eueoa iaeneiaeueieo aaee/ei, a?aei?/aieo /a?ac 2-4 oeaei? i?ney ia?oiai ao?o/aiiy (?<0,05). Eiioeaio?aoe?y IAeA o e?ia? aeinyaaea iaeneiaeueiiai ??aiy aaea /a?ac 1 aeaiue i?ney iiaoi?iiai aaaaeaiiy eaoaeno, eiee aiia i?aeoe/ii ia a?ae??ciyeanue a?ae iaeneiaeueiiai ??aiy, a?aei?/aiiai /a?ac 3-4,5 oeaei? i?ney eiai aaaaeaiiy, ? aei??aithaaea 2,68+0,42 ieI/e. Iiaoi?ia aaaaeaiiy eaoaenieo i?e?inoa? noi?iaiaeaeoaaeinue oaeiae a?eueo ?ioaineaiei c?inoaiiyi o e?ia? e?eueeino? iiaeeo?eiaaieo EI: aaea /a?ac 1-3 aei? ai?no ON o II i?ney ?ieoaaoe?? c ieaciith noaiiaea 234,3+13,0 iea/ia a?eea, ui ia 486% ia?aaeuoaaei ii?iaeueia cia/aiiy (?<0,001) ? ia 20% - eiai iaeneiaeueio aaee/eio, a?aei?/aio i?ney ia?oiai ao?o/aiiy. Oea ii?aeioaaeinue ?c i?enei?aiei oa a?eueo ?ioaineaiei c?inoaiiyi ai?noo ON o e?ia?, oi/a a?aei?/aia caeaaei?noue ia aoea e?i?eiith - i?e??no ??aiy ON aoa a?eueo iii?oiei o ii??aiyii? ?c ca?eueoaiiyi ai?noo aoa?iaaiieo EI. Aaea /a?ac 1 aeaiue i?ney iiaoi?iiai ao?o/aiiy ai?no ON o e?ia? aei??aithaaa 6,37+0,6 iI/e, ui ia 288% ia?aaeuoaaei ii/aoeiao (?<0,001) ? ia 342% - eiio?ieueio aaee/eie (?<0,001), ? aoa o?eueee ia 50% iaioa i?eiaiai cia/aiiy iieacieea, a?aei?/aiiai /a?ac 4-5 oeaei? i?ney o?e?aciaiai aaaaeaiiy eaoaeno. Ii??aiyeueiee aiae?c aeeiai?ee oa ?ioaineaiino? aeine?aeaeaieo iieaciee?a i?ney ia?oiai (eiio?ieueia a?oia) oa iiaoi?iiai iaeii?aciaiai aaaaeaiiy e?ieyi eaoaenieo i?e?inoa? oaeiae na?ae/ea i?i ?icaeoie nainea?e?caoe?? aei iiaoi?ii? ae?? ?iaeoeoi??a aino?iai caiaeaiiy. sse anoaiiaeaii, ia?oa iaeii?aciaa ao?o/aiiy noi?iaiaeaeoaaeinue ?icaeoeii cia/ii a?eueo oiia?eueiaieo oa iaio ?ioaineaieo ?aaeoe?e. Iii?oii neaae?oa aeoeaoaaeenue IOe, ? iaeneiaeueiee ai?no a ieo IAeA aoa ia 72% iaioa, i?ae i?ney iiaoi?iiai iaeii?aciaiai aaaaeaiiy eaoaeno (?<0,001), iaeneiaeueiue i?e??no ai?noo ON o IOe a eiio?ieueieo oiiaao (i?ney ia?oiai iaeii?aciaiai aaaaeaiiy eaoaeno) aoa ia 11% iaioa, i?ae i?ney iiaoi?iiai (?>0,05), a iaeneiaeueia caoiieaiiy EI IOe e?ia? o ipioean?
eoeueoeaoaaiiy a eiio?ieuei?e a?oi? aoei iaioa ia 24% (?<0,01). I?e i?aeoe/ii iaeiaeiaiio nooiai? ci?i iieaciee?a niiioaiii? oa ?iaeoeiaaii? OE i?ney ye ia?oiai, oae ? iiaoi?iiai ao?o/aiiy /an aeinyaiaiiy ?o i?eiaeo cia/aiue aoa ??ciei. sseui a eiio?ieueieo aeine?aeaeaiiyo iaeneiaeuei? aaee/eie aeaieo iieaciee?a a?aei?/aeenue o?eueee /a?ac 2 oeaei?, oi i?ney iiaoi?iiai aaaaeaiiy eaoaeno aiaeia?/iee i?e??no a?aei?/aany /a?ac 1-2 aei?. A oeeo oiiaao a?aei?/aeinue ? a?eueo ae?aaeaia c?inoaiiy o e?ia? ??aiy iiaeeo?eiaaieo EI: ai?no ON o II ia 102%, a IAeA o ne?iaaooe? ia 99% ia?aaeuoaaa i?eia? cia/aiiy aiaeia?/ieo iieaciee?a o oaa?ei eiio?ieueii? apoie (?<0,001). Aiaeia?/iei /eiii, iiaoi?ia ao?o/aiiy i?eaiaeeei aei ?icaeoeo a?eueo cia/ii? AOA. Caaaeueiee ai?no ON o e?ia? i?ney iiaoi?iiai aaaaeaiiy eaoaenieo i?e?inoa? aoa ia 188% a?eueoa, i?ae i?ney ia?oiai iaeii?aciaiai (?<0,05). Ci?anoaaeaiiy aeeiai?ee ?aaeoe?e ia ia?oa oa iiaoi?ia aaaaeaiiy eaoaeno i?iaeaiiino?oaaei, ui iaeneiaeueiee i?e??no caaaeueiiai ON o e?ia? oa iieaciee?a, ui oa?aeoa?ecothoue a?eueii?aaeeeaeueio aeoeai?noue ? IIE, o eiiopieueieo oaa?ei a?aei?/aany ia II aoai? aeine?aeaeaiiy (/a?ac 2 oeaei?), a iieaciee?a aeoeaiino? IOe oa iai?io EI - ia III aoai? (3-5 oeaeaeaiue i?ney ao?o/aiiy). A oie aea /an, iaeneiaeueiee i?e??no an?o aeine?aeaeoaaieo iieaciee?a ipe iiaoi?iiio aaaaeaii? eaoaenieo i?e?inoa? a?aei?/aany aaea ia i?ioyc? 1-ai-2-ai aei?a. ?acoeueoaoe ii?oieia?/ieo aeine?aeaeaiue noaeeiii? no?iee o e?ie?a c nenoaiiith caiaeueiith ?aaeoe??th, aeeeeeaiith aaaaeaiiyi eaoaeno, na?ae/aoue i?i ?icaeoie ci?i, ui oa?aeoa?i? aeey ?aiiueiai aoa?ineea?ico. *a?ac 9 oeaei?a i?ney aaaaeaiiy eaoaenieo i?e?inoa? o no?ioe? ai?oe aeyaeai? aiaieuaa? ci?ie o aeaeyae? iaa?yeo ? aeaneaaiaoe?? AOe, a oaeiae cia/iiai iioiauaiiy ?ioeie o ?acoeueoao? ?? iaa?yeo oa e?i?aeii? ?io?eueo?aoe??. A?aei?/ai? oaeiae ie?ai? ae?eyiee c ia??cei ae?aaeaiith ?io?eueo?aoe??th iaae?? IOe oa iae?ioaaaie. Aiaeia?/i?, aea c aeayeeie e?euee?nieie a?aei?iiinoyie aeai? i?i caeaoi?noue IOe e?ia? aeoeaoaaoe a?eueii?aaeeeaeueia ieeneaiiy, cae?enithaaoe iiaeeo?eaoe?th EI oa i?eaiaeeoe aei ?icaeoeo AOA, io?eiai? i?e iiaeaethaaii? aino?iai nenoaiiiai caiaeueiiai neiae?iio o e?ieee?a o?e?aciaei aioo??oiueiaaiiei aaaaeaiiyi ii 10 IIAe i??iaaiaeo, yeee ? e?iiiie?naoa?eaeii, aeae?eaiei ?c ee?oei aaeoa??e Salmonella typhy, oa a?aeiineoueny aei /enea iaeiiai c iaea?eueo iiooaeieo i?e?iaeieo aeoeaaoi??a ee?oei iae?ioaaaeueiiai ?yaeo. Ii/eiath/e c ia?oeo aei?a i?ney ao?o/aiiy, a?aei?/aeinue c?inoaiiy eiioeaio?aoe?? IAeA o IOe, ui na?ae/eei i?i iineeaiiy ia?ieneaeaoe?? ?o aeanieo iaia?aiieo e?i?ae?a. Aei e?ioey 2-ai oeaeiy aaee/eia oeueiai iieacieea c?inoaea aei 6,6+0,5 ieI/ia a?eea, ui ia 560% (?<0,001), a ua /a?ac 2 oeaei? - a 10 ?ac?a ia?aaeuoaaei ii/aoeiaa cia/aiiy (?<0,001). Aaea a e?ioe? 1-ai oeaeiy ai?no ON o IOe aoa i?aeaeuaiee ia 65% (aei 76,05+6,0 iea/ia a?eea, P<0,001), a a e?ioe? 4-ai - ia 161% (?<0,001). I?eoiaaia ?aaeoeaiinoue IOe /a?ac 1 oeaeaeaiue ia?aaeuoaaea aeo?aeio ia 82% (?<0,001), a ?acoeueoao? /iai ?ioaineai?noue aeiaeaoeiaiai caoiieaiiy EI IOe aoea ca?eueoaia ia 244%. Ia i?ioyc? ianooiieo 3-o oeaei?a ?aaeoeai?noue IOe i?iaeiaaeoaaea c?inoaoe ? aeinyaaea iaeneiaeueii? aaee/eie, yea ia?aaeuoaaea aeo?aeio ia 160% (?<0,001). Aioo??oiueiaaiia aaaaeaiiy i??iaaiaeo noi?iaiaeaeoaaeinue oaeiae iineeaiiyi IIE e?ia?: /a?ac 1 oeaeaeaiue aaee/eia NOE ca?eueoeeanue ia 43% (?< 0,05), Ei ?OE - ia 60%, Imax - ia 58% (?<0,01). Iaeneiaeueiiai cia/aiiy iieacieee ?OE aeinyaaee /a?ac 3 oeaei?: ??aaiue Ei c??n ia 448%, Imax - ia 350% (?<0,001). Eiioeaio?aoe?y IAeA o e?ia? ii/eiaea c?inoaoe c ia?oeo aei?a i?ney aaaaeaiiy i??iaaiaeo ? /a?ac 2 oeaei? aeinyaaea iaeneiaeueiiai ??aiy (1,12+0,10 ieI/e), ia?aaeuoth/e ii/aoeiao ia 195% (?<0,001). Oea ii?aeioaaeinue ?c aeniaaeaiiyi aioeieneaeaioiiai iioaioe?aeo, i?i ui na?ae/eei cieaeaiiy aeoeaiino? eaoaeace e?ia? (ia 37%, ?<0,001) oa ca?eueoaiiy ia 58% Imin ?OE (?<0,001) aaea /a?ac 1 oeaeaeaiue i?ney ao?o/aiiy. Aoa?iaaiiee iioaioe?ae ieacie c?inoaa aaea /a?ac 1 oeaeaeaiue i?ney aaaaeaiiy i??iaaiaeo: ai?no ON o II i?ney ?ieoaaoe?? c ieaciith aoa i?aeaeuaiee ia 48% ? aeinyaaa 62,83+5,50 iea/ia a?eea (?<0,01). Ia i?ioyc? ianooiieo 3-o oeaei?a aoa?iaaii?noue ieacie i?ia?aneaii c?inoaea, ? /a?ac 4 oeaei? ??aaiue ON o iae?ioaaao i?ney ?ieoaaoe?? ia?aaeuoaaa aeo?aeiee ia 148% ? aei??aithaaa 105,3+8,0 iea/ia a?eea (?<0,001). Ai?no o e?ia? caaaeueiiai ON c?inoaa ia?aeaeueii, ? aaea /a?ac 1 oeaeaeaiue a?i noaiiaea 4,98+0,40 iI/e, ui ia 181% ia?aaeuoaaei ii/aoeiaa cia/aiiy (?<0,01). Iai?ee?ioe? 4-ai oeaeiy ai?no ON o e?ia? aeinyaaa iaeneiaeueiiai ??aiy (9,01+0,71 iI/e), yeee aoa ia 409% aeua aeo?aeiiai (?<0,001). Aino?ee caiaeueiee neiae?ii, a?aeoai?aiee ca aeiiiiiaith aioo??oiueiaaiiiai aaaaeaiiy i??iaaiaeo, oaeiae oa?aeoa?ecoaaany caoyaeiith aeeiai?eith oa ?icaeoeii nainea?e?caoe?? ?c aeieeiaiiyi a?eueo ?ioaineaieo ci?i o a?aeiia?aeue ia iiaoi?ia ao?o/aiiy. A ?acoeueoao? iiaoi?ia iaeii?aciaa aaaaeaiiy e?ieeeai i??iaaiaeo (10 IIAe) /a?ac 4 oeaei? i?ney ia?oiai o?e?aciaiai aaaaeaiiy o noia?i?e aeic? 30 IIAe noi?iaiaeaeoaaeinue caa?aaeaiiyi aeoeaiino? IOe ia noaa?eueii i?aeaeuaiiio ??ai?. Oae, aaea /a?ac 1 aeaiue eiioeaio?aoe?y IAeA o IOe aei??aithaaea 5,06+0,50 ieI/ia a?eea, ui iaeaea ia 400% (?<0,001) ia?aaeuoaaei ii/aoeiao (aei ia?oiai o?e?aciaiai aaaaeaiiy i??iaaiaeo). *a?ac 1 oeaeaeaiue ai?no IAeA o IOe ca?eueoeany ua aaea?/? (?<0,001), oiaoi i?aeoe/ii aei iaeneiaeueiiai ??aiy, a?aei?/aiiai i?ney ia?oiai o?e?aciaiai aaaaeaiiy i?aia?aoo. ??aaiue ON o IOe /a?ac 2 aei? i?ney iiaoi?iiai aaaaeaiiy i??iaaiaeo aoa i?aeaeuaiee a?aeiinii aeo?aeiiai ia 115% (?<0,001) aei 90,08+8,50 iea/ia a?eea ? ia i?ioyc? ianooiieo 4-o oeaei?a i?iaeiaaeoaaa c?inoaoe, i?aeoe/ii aeinyaath/e iaeneiaeueiiai cia/aiiy, a?aei?/aiiai i?ney a?eueo ?ioaineaiiai ia?oiai ao?o/aiiy. Ia?aeaeueii a?aei?/aeinue oaeiae ?ioaineaia c?inoaiiy i?eoiaaii? ?aaeoeaiino? IOe: /a?ac 1 oeaeaeaiue a?ae iiiaioo iiaoi?iiai aaaaeaiiy i??iaaiaeo aiia ia 107%, o e?ioe? 4-ai oeaeiy - ia 130% ia?aaeuoaaea ii/aoeiao (?<0,001). A ?acoeueoao? i?ney iiaoi?iiai ao?o/aiiy aeiaeaoeiaa caoiieaiiy EI IOe i?e ?o noeioeyoe?? a oiiaao eoeueoo?e ia i?ioyc? 3-o oeaei?a aoei i?eaeecii o 1,5-2 ?ace a?eueoei, i?ae o aeo?aeiiio noai? (?<0,001). Iiaoi?ia aaaaeaiiy i??iaaiaeo noi?iaiaeaeoaaeinue cia/iith ?ioaineo?eaoe??th IIE e?ia?, ? aaea /a?ac 1 aeaiue aaee/eia NOE ia?aaeuoaaea ii/aoeiao ia 49% (?<0,001), i?aeoe/ii ia a?ae??ciyth/enue a?ae iaeneiaeueii?, ui a?aei?/aeanue /a?ac 1 oeaeaeaiue i?ney ia?oiai aaaaeaiiy i?aia?aoo. I?eiaiai cia/aiiy NOE aeinyaaea /a?ac 2 oeaei? i?ney iiaoi?iiai aaaaeaiiy, ia 104% (?< <0,001) ia?aaeuoth/e iaeneiaeueia cia/aiiy i?ney ia?oiai o?e?aciaiai aaaaeaiiy i??iaaiaeo. Aiaeia?/iei /eiii c?inoaee i?ney iiaoi?iiai ao?o/aiiy iieaciee? ?OE: aaea /a?ac 1 aeaiue aaee/eia Ai ?OE ia 174% ia?aaeuoaaea ii/aoeiaa cia/aiiy (?<0,001), a ?ioaineai?noue Imax ?OE /a?ac 1 oeaeaeaiue i?ney iiaoi?iiai aaaaeaiiy i??iaaiaeo aoea ia 204% a?eueoa aeo?aeii? (?<0,001). Eiioeaio?aoe?y o e?ia? IAeA i?ney iiaoi?iiai aaaaeaiiy i??iaaiaeo o?eaaeee /an caeeoaeanue noaa?eueii i?aeaeuaiith ? a e?ioe? 4-ai oeaeiy noaiiaeea 0,83+0,06 ieI/e, ia?aaeuoth/e ii/aoeiao ia 118% (?<0,001). Oea ii?aeioaaeinue ?c cia/iei cieaeaiiyi aioeieneaeaioiiai iioaioe?aeo ieacie: /a?ac 1 aeaiue aeoeai?noue eaoaeace e?ia? ciaioeeanue aaea?/?, a aaee/eia Imin ?OE c?inea ia 63% a?aeiinii aeo?aeiiai cia/aiiy (?<0,001) ? i?aeoe/ii ia a?ae??ciyeanue a?ae iaeneiaeueiiai ?? cia/aiiy i?ney o?e?aciaiai aaaaeaiiy i??iaaiaeo. I?ney iiaoi?iiai aaaaeaiiy i??iaaiaeo a?aei?/aany ? a?eueo i?enei?aiee ?icaeoie ii?ooaiue iai?io EI e?ia?: ??aaiue aoa?iaaiiino? ieacie aeinyaaa iaeneioia aaea /a?ac 2 oeaei?, ia?aaeuoth/e eiio?ieueiee ia 180% (?<0,001). Caeiiii??ia ca?eueoaiiy ai?noo ON o ieaci? a?aei?/aeinue o e?ioe? 1-ai oeaeiy i?ney iiaoi?iiai aaaaeaiiy i??iaaiaeo, a iaeneiaeueiiai cia/aiiy (3,33+0,30 iI/e), yea ia?aaeuoaaei aeo?aeia ia 75% ? aoei i?aeoe/ii ??aiei iaeneiaeueiiio cia/aiith i?ney ia?oiai aaaaeaiiy i?aia?aoo, AOA aeinyaaea o e?ioe? 2-ai oeaeiy. Aeey i?aeoaa?aeaeaiiy iieiaeaiiy i?i aaaeo/o ?ieue ieneaeaoeaiiai no?ano a aoa?iaaii?e iiaeeo?eaoe?? EI e?ia? nenoaiiee caiaeueiee neiae?ii a /anoei? aeine?ae?a a?aeoai?thaaany oeyoii aaaaeaiiy eaoaenieo i?e?inoa? ia oii? aioeieneaeaioii? oa?ai?? (ii?aeiaia canoinoaaiiy a?oai?i?a N oa A ca aeaa oeaei? aei ao?o/aiiy oa ia i?ioyc? anueiai /ano i?iaaaeaiiy aenia?eiaioo). Iiaeaethaaiiy aino?iai caiaeaiiy ia oeueiio oii? noi?iaiaeaeoaaeinue, ye ? a eiio?ie?, ae?aciith aeoeaaoe??th IOe, ? /a?ac 1 oeaeaeaiue aioo??oiueiee?oeiiee ??aaiue IAeA aeinyaaa iaeneiaeueiiai cia/aiiy (3,30+0,25 ieI/ia a?eea), iaeaea ia 500% ia?aaeuoth/e ii/aoeiaee (?<0,001). O eiio?ie? iaeneiaeueiee i?e??no aeaiiai iieacieea aoa i?eaeecii aaea?/? a?eueoei ? noaiiaea 932% (?<0,001). Ia i?ioyc? ianooiieo aeaio oeaei?a ai?no IAeA o IOe a a?oi? e?eiaaieo oaa?ei caa??aaany ia ??ai? 45-50% a?ae eiai cia/aiiy a eiio?ieuei?e a?oi?. Ia?aeaeueii a?aei?/aeinue ia?inoaiiy caeaoiino? IOe i?iaeoeoaaoe ieneae acioo: ?? iaea?eueoa cia/aiiy aoei a?aei?/aii a e?ioe? 3-ai oeaeiy ? a 4 ?ace ia?aaeuoaaei ii/aoeiaa, a oie /an ye o eiio?ie? oeae iieaciee ca?eueoeany i?eaeecii a 17 ?ac?a. Oe? ?aaeoe?? ni?aiaaeaee ?c ca?eueoaiiyi ai?noo ON o IOe, yea oa?aeoa?ecoaaeinue i?eaeecii oaeith ae aeeiai?eith, ye ? a eiio?ie?, i?ioa cia/ii iaioith ae?aaeaii?noth. Oae, /a?ac 1 oeaeaeaiue ai?no ON o IOe e?eiaaieo e?ie?a aoa ia 18% a?eueoa ii/aoeiaiai ??aiy (?<0,05), i?ioa ia 36% iaioa o ii??aiyii? c eiio?ieai (?<0,01). Iaeneiaeueiiai cia/aiiy (91,3+8,0 iea/ia a?eea), yea aoei aaea?/? a?eueoa ii/aoeiai? aaee/eie (?<0,001), ai?no ON o IOe aeinyaaa a e?ioe? 5-ai oeaeiy i?ney ao?o/aiiy, oiae? ye a eiio?ie? ai?no ON o IOe iaeneiaeueii ia?aaeuoaaa aeo?aeiee ia 324% (?<0,001). Canoinoaaiiy aioeieneaeaioiiai caoenoo i?eaiaeeei aei aaea?/? iaioi? aeoeaaoe?? IIE e?ia? a oiiaao nenoaiiiai caiaeaiiy. Oae, iaeneiaeueia ca?eueoaiiy Ei ?OE, a?aei?/aia a e?ioe? 1-ai oeaeiy, aeinyaaei o?eueee 60% (?<0,001), oiae? ye o a?oi? eiio?ieueieo oaa?ei oeae iieaciee c?inoaa ia 136% (?<0,01). Ia i?ioyc? ianooiieo o?ueio oeaei?a ??aaiue Ei ?OE caa??aaany noaa?eueii i?aeaeuaiei (ia 44 - 48% o ii??aiyii? c ii/aoeiaei, ?<0,001), a oie /an, ye o eiio?ie? ?ioaineai?noue Ai ia oeueiio aoai? ia?aaeuoaaea ii/aoeiaa cia/aiiy ia 70 -75%. A e?ioey oinoiai oeaeiy o e?eiaaieo oaa?ei niinoa??aaeanue iiaia ii?iae?caoe?y Ai ?OE ia a?aei?io a?ae eiio?ieueieo, o yeeo a oeae /an cia/aiiy Ai ?OE caeeoaeinue ia 61% aeua ii/aoeiaiai (?<0,001). I?eaeecii a oaeiio ae ianyc? o e?eiaaieo oaa?ei aoee iaioeie ci?ie iieaciee?a ?OE (Imax oa Imin). I?ney canoinoaaiiy eiiieaeno aioeieneaeaioieo a?oai?i?a eiioeaio?aoe?y IAeA o ne?iaaooe? e?ia? cieceeanue o aeo?aeiiio noai? a n?aaeiueiio ia 25% (?<0,05), ? aaaaeaiiy ia oeueiio oii? eaoaenieo i?e?inoa? i?eaiaeeei aei cia/ii iaio ?ioaineaiiai ?? c?inoaiiy. *a?ac 1 oeaeaeaiue ??aaiue IAeA o ne?iaaooe? aei??aithaaa 0,9+0,1 ieI/e ? i?eaeecii ia 50% ia?aaeuoaaa ii/aoeiaee (?<0,05), oiae? ye o eiio?ie? eiai i?e??no noaiiaea 64% (?<0,01) ? caa??aaany, aeinyaath/e iaeneiaeueiiai cia/aiiy - 247% (?<0,001) a e?ioe? 5-ai oeaeiy. Aei e?ioey 6-ai oeaeiy a?aei?/aeanue i?aeoe/ii iiaia ii?iae?caoe?y ai?noo IAeA a e?ia? o e?eiaaieo e?ie?a, a oie /an ye o eiio?ieueieo a?i caeeoaany ia 95% aeua ii/aoeiaiai cia/aiiy (?<0,05). I?io?eaeoe/ia canoinoaaiiy aioeieneaeaioiiai eiiieaeno noi?iaiaeaeoaaeinue i?aeaeuaiiyi aeoeaiino? eaoaeace e?ia? o aeo?aeiiio noai? ia 70% (?<0,001), ? a?aeoai?aiiy ia oeueiio oii? aino?iai caiaeaiiy i?eaiaeeei aei iiaeaeueoiai ?? i?aeaeuaiiy. *a?ac 1 oeaeaeaiue i?ney ao?o/aiiy aeoeai?noue eaoaeace c?inoaea ua ia 32% (?<0,05) ? aoea ia 265% aeua ??aiy, aecia/aiiiai /a?ac 1 oeaeaeaiue i?ney aaaaeaiiy eaoaenieo i?e?inoa? o eiio?ie? (?<0,001). Ia i?ioyc? ianooiieo o?ueio oeaei?a aeoeai?noue eaoaeace o ne?iaaooe? e?ia? e?eiaaieo oaa?ei cieaeoaaeanue aei ii/aoeiaiai ??aiy, oiae? ye o eiio?ieueieo oaa?ei aiia caeeoaeanue ia 61% iaioa ii/aoeiai?. Canoinoaaiiy aioeieneaeaio?a ia iiia?aaeaeaei iiai?noth ia?inoaiiy eiioeaio?aoe?? aoa?iaaieo EI a e?ia? i?ney aaaaeaiiy eaoaenieo i?e?inoa?. Oae, /a?ac 1 oeaeaeaiue ai?no ON o II i?ney ?ieoaaoe?? c ieaciith noaiiaea 58,3+3,5 iea/ia a?eea - ia 45% a?eueoa ii/aoeiaiai cia/aiiy (?<0,001), a oie /an, ye i?e??no oeueiai iieacieea o eiio?ie? a e?ioe? 1-ai oeaeiy noaiiaea 384% (?< <0,001). Ia i?ioyc? ianooiieo 3-o oeaei?a a?aei?/aeinue iinooiiaa i?aeaeuaiiy ??aiy aoa?iaaiieo EI o e?ia? e?eiaaieo oaa?ei aei iaeneiaeueii cia/aiiy, yea noaiiaeei 334% a?aeiinii aeo?aeiiai (?<0,001), a oie /an ye o eiio?ieueieo oaa?ei iaeneiaeueiee i?e??no ??aiy aoa?iaaiieo EI o e?ia? aei??aithaaa 883% (?<0,01). Iaeneiaeueia i?aeaeuaiiy ??aiy ON o ne?iaaooe? e?ia? e?eiaaieo oaa?ei aeinyaaei o?eueee 214% (?<0,001), oiae? ye o eiio?ieuei?e i?aea?oi? aiii noaiiaeei 765% (?<0,001). I?io?eaeoe/ia i?iaaaeaiiy aioeieneaeaioii? oa?ai?? ni?eyei oaeiae i?enei?ai?e ii?iae?caoe?? ii?ooaiiai iai?io EI a oiiaao nenoaiiiai caiaeueiiai neiae?iio. O e?eiaaieo oaa?ei aei e?ioey 6-ai oeaeiy aoa?iaaii?noue ieacie o?eueee ia 98% ia?aaeuoaaea aeo?aeio (?<0,001), a oie /an ye o eiio?ieueieo /a?ac 6 oeaei?a i?ney aaaaeaiiy eaoaeno aiia caeeoaeanue i?aeaeuaiith ia 387% (?<0,001). Iiaoi?ia iaeii?aciaa aaaaeaiiy e?eiaaiei oaa?eiai eaoaenieo i?e?inoa? noi?iaiaeaeoaaeinue o?eueee oaiaeaioe??th aei i?aeaeuaiiy ??aiy aeoeaiino? IOe e?ia?, a oie /an ye o eiio?ieueieo oaa?ei oe? ci?ie iineee caeiiii??iee oa?aeoa?, ? eiioeaio?aoe?y a ieo IAeA /a?ac 1 aeaiue ia 185% ia?aaeuoaaea ii/aoeiaa cia/aiiy (?<0,001). I?e??no ai?noo ON o IOe o e?eiaaieo oaa?ei /a?ac 1 oeaeaeaiue aeinyaaa 23% ii/aoeiaiai cia/aiiy (?<0,05), a oie /an ye o eiio?ieueieo oaa?ei /a?ac 3-5 aei?a i?ney iiaoi?iiai aaaaeaiiy eaoaeno a?i noaiiaea 57% (?<0,001). Ca?eueoaiiy ai?noo ON o IOe i?ney aeiaeaoeiai? noeioeyoe??, aeeeeeaii? eoeueoeaoaaiiyi, /a?ac 1-2 aei? i?ney iiaoi?iiai aaaaeaiiy e?eiaaiei e?ieyi eaoaenieo i?e?inoa? iaei oa?aeoa? oaiaeaioe??, oiae? ye o eiio?ieueieo oaa?ei aiii aeinyaaei 42% (?<0,001). Aaee/eia ?aaeoe?? aeiaeaoeiaiai iiaeeiaiiy EI IOe e?ia? i?e eoeueoeaoaaii? o e?eiaaieo oaa?ei aoea i?eaeecii ia 40% iaioa aiaeia?/ii? ?aaeoe?? o eiio?ieueieo e?ie?a. Aeoeaaoe?y a?eueii?aaeeeaeueieo i?ioean?a i?ney iiaoi?iiai aaaaeaiiy eaoaeno e?ieyi ia oii? aioeieneaeaioii? oa?ai?? oaeiae aoea cia/ii iaio ?ioaineaiith, i?ae o eiio?ie?. *a?ac 1 aeaiue aaee/eia NOE i?aeaeueeanue ia 40% (?<0,01), oiae? ye o eiio?ieueieo oaa?ei oeae iieaciee ca?eueoeany ia 84% (?<0,001), c?inoaiiy Ei ?OE o e?eiaaieo oaa?ei aoei ia 31% iaioa, i?ae o eiio?ieueieo (?<0,001), Imax c?inoaa o ia?oiio aeiaaeeo o?eueee ia ??ai? oaiaeaioe??, oiae? ye o ae?oaiio a?i ca?eueoeany ?noioii oa a??ia?aeii (ia 24%, ?<0,05). Aeoeai?noue eaoaeace e?ia? i?ney iiaoi?iiai aaaaeaiiy eaoaeno ia oii? aioeieneaeaioii? oa?ai?? i?aeoe/ii ia ci?ieeanue, a oie /an ye o eiio?ie? aiia a??ia?aeii cieceeanue. A ?acoeueoao? aaea /a?ac 1 aeaiue aeoeai?noue eaoaeace o e?eiaaieo e?iee?a aoea ia 163% aeua, i?ae o eiio?ieueieo (?<0,01). ?acoeueoaoii ciaioaiiy ?ioaineaiino? ieneaeaoeaiiai no?ano aoei iiia?aaeaeaiiy ii?ooaiue iai?io EI, ? /a?ac 1 aeaiue i?ney iiaoi?iiai aaaaeaiiy eaoaeno c?inoaiiy ai?noo iiaeeo?eiaaieo EI o e?eiaaieo e?ie?a iaei oa?aeoa? oaiaeaioe??, oiae? ye o eiio?ie? i?e??no ai?noo iiaeeo?eiaaieo EI noaiiaea 60% (?<0,001). Ai?no IAeA o ne?iaaooe? e?ia? e?eiaaieo oaa?ei c?inoaa i?ney aaaaeaiiy eaoaeno ia 65% iaioa aiaeia?/iiai iieacieea o eiio?ieueieo (?<0,01). Aioeieneaeaioia oa?ai?y iiai?noth iiia?aaeaeaea ?icaeoie AOA i?ney iiaoi?iiai aaaaeaiiy eaoaeno: ??aaiue ON o ne?iaaooe? caeeoaany o iaaeao ii/aoeiaiai cia/aiiy ? aoa ia 85% ieae/a o ii??aiyii? c iaeneiaeueieie eiai ci?iaie o eiio?ieueieo oaa?ei, aecia/aieie /a?ac 1 aeaiue i?ney iiaoi?iiai iaeii?aciaiai aaaaeaiiy eaoaenieo i?e?inoa? (?<0,001). Oaeei /eiii, io?eiai? aeai? na?ae/aoue i?i oa, ui iaeaaaeeea?oei iane?aeeii nenoaiiiai caiaeueiiai neiae?iio, ui aeieea? ye a i?e?iaeieo oiiaao a ?acoeueoao? ?ioaeoe?eiiai i?ioeano, oae ? i?e eiai iiaeaethaaii? a oiiaao aenia?eiaioo, ? ?icaeoie ieneaeaoeaiiai no?ano aiane?aeie aeoeaaoe?? ee?oei e?ia?, ia?o ca ana - IOe. A ?acoeueoao? a?aeaoaa?oueny cia/ia c?inoaiiy aoa?iaaiiiai iioaioe?aeo e?ia? ca ?aooiie EIIU, ui caciaee a?eueii?aaeeeaeueiiai ieeneaiiy, ? a inoaoi/iiio ?acoeueoao? - ?icaeoie o?aiceoi?ii? AOA. Iiaoi?ia a?aeoai?aiiy nenoaiiiai caiaeueiiai neiae?iio i?eaiaeeoue aei a?eueo i?enei?aiiai ? cia/iiai ii?ooaiiy iai?io EI, ui aecia/a?oueny nainea?e?caoe??th oe??? nenoaie aei iiaoi?ii? ae?? iaaeeaoi??a caiaeaiiy ? iiaea aooe iniiaith aeey ?icaeoeo no?eei? AOA. Canoinoaaiiy i?io?eaeoe/ii? aioeieneaeaioii? oa?ai?? iiia?aaeaeo? ?icaeoie ieneaeaoeaiiai no?ano, iacaaaeath/e ia ae?aaeaio aeoeaaoe?th IOe, cieaeo? ?ioaineai?noue ii?ooaiue iai?io EI e?ia?, nooi?iue ia?inoaiiy ?? aoa?iaaiiiai iioaioe?aeo oa onoaa? aeieeiaiiy AOA. O a?aeiia?aeiino? aei cai?iiiiiaaii? a?iioace, ii?ooaiiy iai?io EI oa ?icaeoie AOA iathoue aoi?eiiee oa?aeoa? ? ? iane?aeeii ia?aeenii? iiaeeo?eaoe?? EI a oiiaao ae?aaeaiiai ieneaeaoeaiiai no?ano. A oie aea /an, c oeeo iiceoe?e aaaeei iiynieoe i?e?iaeo c?inoaiiy aoa?iaaiiino? e?ia? i?e ia?aeiiiio ii?ooaii? iai?io EI, ui aeieea? i?e iaaeeeoeiaiio iaaeoiaeaeaii? ON a i?aai?ci, yea ? aei iei?oiueiai /ano aaaaoi ooi c aeine?aeiee?a ?icaeyaea? ye aaaeo/ee ao?ieia?/iee oaeoi? aoa?ineea?ico. Aeey ae??oaiiy oeueiai ieoaiiy caeaaei?noue i?ae aeoeai?noth IOe, ?ioaineai?noth a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a e?ia?, ?? aoa?iaaii?noth oa ??aiai caaaeueiiai ON aeine?aeaeoaaeanue ia eeane/i?e aenia?eiaioaeuei?e iiaeae? ae?iaioa?iiai aoa?ineea?ico, ui a?aeoai?thaaeanue oeyoii o?eaaeiai oo?eiaiiy e?ie?a ia aoa?iaaii?e ae??o?. Anoaiiaeaii, ui aoa?iaaiia ae??oa aaea ia i?ioyc? ia?oeo o?ueio aei?a noi?iaiaeaeoaaeanue caeiiii??iei ?icaeoeii AOA - ??aaiue ON o e?ia? i?aeaeueany ia 112% (3,68+0,25 iI/e, ?<0,001). Oeae aoaeo ii?aeioaaany c c?inoaiiyi e?eueeino? oee?eoethth/eo iiaeeo?eiaaieo EI, ia ui aeacoaaee ci?ie eiioeaio?aoe?? IAeA o e?ia? oa ?acoeueoaoe a?ioanooaaiiy ca aeiiiiiaith II. Oae, ??aaiue ON a inoaii?o i?ney ?ieoaaoe?? c aeine?aeaeoaaiith ieaciith noaiiaea 65,47+4,50 iea/ia a?eea, ui ia 63% ia?aaeuoaaei ii/aoeiaa cia/aiiy (?<0,001). Eiioeaio?aoe?y IAeA o ne?iaaooe? ca?eueoeeanue ia 88%, ? oe? ci?ie oaeiae iaee caeiiii??iee oa?aeoa? (?<0,001). Ia?aeaeueii a?aei?/aeinue i?aeaeuaiiy ?ioaineaiino? IIE e?ia?: cia/aiiy A? ?OE ca?eueoeeinue ia 31% (?<0,001), Imax - ia 25% (?<0,01), Imin - ia 45% (?<0,05). A oie aea /an, iieacieee aeoeaiino? IOe o ia?o? 3 aei? ci?ithaaeenue iaio caeiiii??ii - ai?no IAeA o IOe oa ?o oaaioeeoa?ia aeoeai?noue ia a?ae??ciyeenue a?ae ii/aoeiaeo cia/aiue, oi/a ??aaiue ON o IOe ca?eueoeany ia 25% (P<0,01), a i?ney eoeueoeaoaaiiy IOe a?i aoa ia 30% aeua ??aiy i?ney aiaeia?/ii? ?aaeoe?? o ii?iaeueieo oaa?ei (?<0,01). A ?acoeueoao? ??aaiue i?eoiaaii? ?aaeoeaiino? IOe aaea o oeae /an ia 103% ia?aaeuoaaa ii/aoeiaee (?<0,05). *a?ac 1 oeaeaeaiue aoa?iaaiii? ae??oe ??aaiue ON o e?ia? c??n ia 180% o ii??aiyii? c ii/aoeiaei (aei 4,85+0,50 iI/e, ?<0,001), ? oea ii?aeioaaeinue c iiaeaeueoei i?e?inoii aoa?iaaiiino? e?ia?. Ai?no ON o iae?ioaaao i?ney ?ieoaaoe?? c ieaciith noaiiaea 85,65+6,00 iea/ia a?eea, ui aoei ia 113% a?eueoa, i?ae a oiiaao eiio?ieth (?<0,001), eiioeaio?aoe?y IAeA o ne?iaaooe? ia?aaeueea ia 133% ii/aoeiaa cia/aiiy ? aei??aithaaea 1,89+0,10 ieI/e (?<0,001). Caa??aaeenue ia noaa?eueii iii??ii i?aeaeuaiiio ??ai? ?ioaineai?noue IIE e?ia?, oa aeoeai?noue IOe, eiioeaio?aoe?y IAeA a yeeo c?inea ia 122% (aei 1,11+0,10 ieI/ia a?eea, ?<0,001) a?aeiinii ii/aoeiai?. Ai?no ON o IOe ia 22% ia?aaeuoaaa aeo?aeia cia/aiiy (?<0,01), a iieaciee ?o i?eoiaaii? ?aaeoeaiino? (??aaiue ON o IOe i?ney eoeueoeaoaaiiy) ca?eueoeany ia 66% o ii??aiyii? c aaee/eiith ?aaeoe?? o ii/aoeiaiio noai? (?<0,001). ?ioaineai?noue aeiaeaoeiaiai iiaeeiaiiy EI ?c na?aaeiaeua IOe i?e eoeueoeaoaaii? i?eaeecii o 10 ?ac?a ia?aaeuoaaea aaee/eio ii/aoeiai? ?aaeoe?? (?< <0,001). A e?ioe? 2-ai oeaeiy ai?no ON o e?ia? c??n aei ??aiy 6,42+0,40 iI/e ? ia 270% ia?aaeuoaaa ii/aoeiaee (?<0,001). Ia?aeaeueii ca?eueoeany ai?no o e?ia? iiaeeo?eiaaieo EI, ? ??aaiue ON o II i?ney ?ieoaaoe?? c ieaciith noaiiaea 207,5+10,8 iea/ia a?eea, ui aeacoaaei ia a?eueo i?ae 5-?aciaa c?inoaiiy caoiieaiiy ieie EI o ii??aiyii? c ii?iith (?<0,01). Ai?no IAeA o ieaci? ca?eueoeany ia 220% o ii??aiyii? c ii/aoeiaei cia/aiiyi ? aeinyaaa 2,59+0,20 ieI/e, a a IOe - ia 140% aei 1,2+0,1 ieI/ia a?eea (?<0,001). I?e oeueiio a?aei?/aany /?oeee ia?aeaeeci i?ae ca?eueoaiiyi o e?ia? e?eueeino? iiaeeo?eiaaieo EI oa nooiaiai ia?inoaiiy aeoeaiino? IOe. Cia/ii i?aeaeueeanue ? oaaioeeoa?ia aeoeai?noue IOe: aaee/eia IO ia?aaeueea ii/aoeiaee iieaciee a?eueo i?ae o 3 ?ace (?<0,001), a O* - ia 83% (?<0,001); oea ii?aeioaaeinue ?c a??ia?aeiei ca?eueoaiiyi i?iaeoeoe?? ieneaeo acioo IOe. Ai?no ON o IOe a e?ioe? 2-ai oeaeiy aei??aithaaa 132,87+5,40 iea/ia a?eea, ia?aaeuoth/e ia 200% ii/aoeiaa cia/aiiy (?<0,001), oiae? ye ?ioaineai?noue aeiaeaoeiaiai caoiieaiiy IOe EI o i?ioean? eoeueoeaoaaiiy iaeaea o 17 ?ac?a ia?aaeuoaaea aeo?aeio ?aaeoe?th (?<0,001). I?iaaaeaiee ia?iee ei?aeyoe?eiee aiae?c aeyaea iayai?noue i?yii? iiceoeaii? caeaaeiino? i?ae ai?noii ON o IOe aei oa i?ney ?ieoaaoe?? oa ??aiai aoa?iaaiieo EI o e?ia? (r=0,41 ? 0,66 a?aeiia?aeii), a oaeiae i?ae ai?noii o e?ia? IAeA oa ON (r=0,717). A oie aea /an, aioeieneaeaioia aeoeai?noue e?ia? i?iaeiaaeoaaea cieaeoaaoenue, i?i ui na?ae/eea aaea?/? ciaioaia (?<0,001) aeoeai?noue eaoaeace. Ia i?ioyc? ianooiieo 2-o oeaei?a a?aei?/aeinue i?ia?anoaaiiy AOA, ? ai?no ON o e?ia? aeinyaaa 9,05+0,60 iI/e, ui aoei ia 420% a?eueoa ii/aoeiaiai (?<0,001); aoa?iaaii?noue e?ia? caeeoaeanue noaa?eueii i?aeaeuaiith (i?eaeecii o 5 ?ac?a, ?<0,001). I?iaeiaaeoaaea ca?eueooaaoenue eiioeaio?aoe?y IAeA o ne?iaaooe? ? aeinyaaea ??aiy 3,89+0,30 ieI/e, ui ia 380% ia?aaeuoaaa aeo?aeiee (?<0,001); caa??aaeanue oaiaeaioe?y aei ca?eueoaiiy iieaciee?a OE, a aeoeai?noue eaoaeace caeeoaeanue cia/ii cieaeaiith o ii??aiyii? c aeo?aeiith (ia 53%, ?<0,001). I?aeaeueeanue aeoeai?noue IOe: eiioeaio?aoe?y a ieo IAeA aoea ca?eueoaia ia 274% o ii??aiyii? c ii/aoeiaith (?<0,001) aei 1,87+0,10 ieI/ia a?eea; ai?no ON a IOe aei??aithaaa 355,51+10,10 iea/ia a?eea, ui ia 697% ia?aaeuoaaei aeo?aeiee (?<0,001). ?ioaineai?noue caoiieaiiy EI IOe o i?ioean? eoeueoeaoaaiiy caeeoaeanue iaeaea o 16 ?ac?a a?eueoa ii/aoeiai? (?<0,001). Cia/ii i?aeaeuaieie caeeoaeenue caeaoi?noue IOe aea?eueithaaoe ieneae acioo ? ?o oaaioeeoa?ia aeoeai?noue. Ia?iee ei?aeyoe?eiee aiae?c anoaiiaea iayai?noue ia oeueiio aoai? aeine?aeaeaiue neeueii? iiceoeaii? ei?aeyoe?eii? caeaaeiino? (r=0,71) i?ae ai?noii IAeA o IOe oa o ne?iaaooe? e?ia?, ui na?ae/eei i?i c?inoaiiy cia/ouino? IOe o i?aeo?eiaii? aeniei? aoa?iaaiiino? ieacie. Ia?aeaeueii a?aeaoaaeinue iineeaiiy a?aei?/aiiai 2 oeaeiyie ?ai?oa iiceoeaiiai ei?aeyoe?eiiai ca’yceo i?ae ai?noii o e?ia? IAeA oa caaaeueiiai ON (r=0,83), ui aeaco? ia iayai?noue caeaaeiino? i?ae aoa?iaaii?noth ieacie oa ?icaeoeii AOA. Ia i?ioyc? 6-ai oeaeiy AOA i?iaeiaaeoaaea c?inoaoe, ? ??aaiue caaaeueiiai ON a e?ia? noaiiaea 11,23+1,00 iI/e, ia?aaeuoth/e ii/aoeiaee ia 545% (?<0,001). Ca?eueooaaeanue oaeiae ? e?euee?noue iiaeeo?eiaaieo EI: iaeiie/aiiy ON II a?eueo i?ae o 8 ?ac?a i?aaeuoaaei ii?iaeueia cia/aiiy ? aei??aithaaei 335,4+20,6 iea/ia a?eea (?<0,001). Eiioeaio?aoe?y IAeA o ne?iaaooe? i?aeoe/ii ia ci?ieeanue o ii??aiyii? c iiia?aaei?i aoaiii ? noaiiaeea 3,66+0,50 ieI/e, ui aoei ia 352% a?eueoa ii/aoeiai? aaee/eie (?<0,001). Oe? ci?ie ii?aeioaaeenue ?c ae?aaeaiei ia?inoaiiyi iieaciee?a OE: aaee/eie NOE ia 104%, a Ai ia 72% ia?aaeuoaaee ii/aoeia? cia/aiiy (?<0,001), ?ioaineai?noue Imax oa Imin ?OE aoea i?aeaeuaia a?aeiia?aeii ia 113 ? 60% (?<0,01). I?ioa i?e oeueiio a?aei?/aeanue cia/ia ii?iae?caoe?y aeoeaiino? eaoaeace o ne?iaaooe?, yea ia 45% ia?aaeuoaaea aeo?aeio (?<0,05). Ia?iee ei?aeyoe?eiee aiae?c aeyaea ia oeueiio aoai? iayai?noue neeueiiai iiceoeaiiai ca’yceo (r=0,56) i?ae iieacieeaie OE oa ??aiai ON o II i?ney ?ieoaaoe?? c ieaciith, ui na?ae/eei i?i c?inoaiiy cia/ouino? a?eueii?aaeeeaeueieo i?ioean?a a i?aeo?eiaii? aeniei? aoa?iaaiiino? ieacie. Ai?no ON o IOe ia i?ioyc? 6-ai oeaeiy aoa?iaaiii? ae??oe c?inoaa aei 487,01+21,50 iea/ia a?eea - ia 37% a?aeiinii eiai cia/aiiy ia iiia?aaeiueiio aoai? (?<0,001), ? ia 992% a?aeiinii ii/aoeiaiai (?<0,001). A oie aea /an, iieacieee aeoeaiino? IOe ciaioeeenue, ? caoiieaiiy EI ?c na?aaeiaeua i?e eoeueoeaoaaii? aoei ia 67% iaioa o ii??aiyii? c iiia?aaei?i aoaiii (?<0,05), i?ioa a 5 ?ac?a ia?aaeuoaaei aeo?aeia (?<0,05). A?eueo i?ae o 2 ?ace ciaioeeanue caeaoi?noue IOe i?iaeoeoaaoe ieneae acioo, i?ioa aiia caeeoaeanue iaeaea o 3 ?ace aeua ii/aoeiaiai cia/aiiy. Aiaeia?/iei /eiii oaaioeeoa?ia caeaoi?noue IOe a??ia?aeii cieaeoaaeanue a?aeiinii iaeneiaeueiiai cia/aiiy, a?aei?/aiiai o e?ioe? 2-ai oeaeiy: IO ciaioeany ia 25%, aea caeeoaany o 2 ?ace aeua ii/aoeiaiai (?<0,05), O* cieceeinue ia 24% ? o?eueee ia 40% ia?aaeuoaaei ii/aoeiaee ??aaiue (?<0,05). O e?ioe? 8-ai oeaeiy aoa?iaaiii? ae??oe ??aaiue ON o e?ia? aoa i?aeaeuaiee o 10 ?ac?a o ii??aiyii? c ii/aoeiaei ? aeinyaaa 17,21+2,50 iI/e (?< <0,001). Ia?aeaeueii i?iaeiaaeoaaea c?inoaoe e?euee?noue iiaeeo?eiaaieo EI o e?ia?: iaeiie/aiiy ON o II i?ney ?ieoaaoe?? c ieaciith ia 985% ia?aaeuoaaei aaee/eio ii/aoeiai? ?aaeoe?? (?<0,001) ? ia 30% - aaee/eio ?aaeoe?? o e?ioe? 6-ai oeaeiy (?<0,05) ? aei??aithaaei 436,0+20,5 iea/ia a?eea. ??aaiue IAeA o ieaci? i?aeoe/ii ia a?ae??ciyany a?ae oiai, yeee aoa a?aei?/aiee /a?ac 4 ? 6 oeaei?a, ? caeeoaany ia 388% aeua aeo?aeiiai (?<0,001). A?aei?/aeanue oaiaeaioe?y aei ciaioaiiy iieaciee?a OE, i?ioa aiie caeeoaeenue a??ia?aeii i?aeaeuaieie. Ia oeueiio oii? caa??aaeinue c?inoaiiy aeoeaiino? eaoaeace, yea ia 62% ia?aaeuoaaea ii/aoeiaa cia/aiiy (?<0,05). Caa??aaany i?aeaeuaiei ??aaiue aeoeaiino? IOe: eiioeaio?aoe?y a ieo IAeA ia a?ae??ciyeanue a?ae iiia?aaeiuei? ? ia 280% ia?aaeuoaaea ii/aoeiao (?<0,001). Caeeoaeanue i?aeaeuaiith a?aeiinii aeo?aeii? oaaioeeoa?ia aeoeai?noue IOe: IO - ia 84%, a O* - ia 25% ia?aaeuoaaee ii/aoeia? cia/aiiy (?<0,05). A oie aea /an, i?iaeoeoe?y IOe ieneaeo acioo iiaa?oaeanue i?aeoe/ii aei ii/aoeiaiai ??aiy o ca’yceo ?c iiaeeeaei nionoioaiiyi ?iaeoeiaaii? NO-neioaoace o ?acoeueoao? o?eaaei? aeoeaaoe??. Ai?no ON o IOe cieceany ia 38% a?aeiinii i?eiaiai cia/aiiy (?<0,001), a?aei?/aiiai ia iiia?aaeiueiio aoai? aeine?aeaeaiiy, aea caeeoaany ia 578% a?eueoa o ii??aiyii? c ii/aoeiaei (?<0,001) ? aei??aithaaa 301,6+12,6 iea/ia a?eea. Ciaioeeanue oaeiae ?aaeoeai?noue IOe, ? ai?no a ieo ON i?ney ?ieoaaoe?? aoa ia 25% iaioa aiaeia?/iiai iieacieea ia iiia?aaeiueiio aoai? (?<0,001), aea ia 833% a?eueoa oiai, ui a?aei?/aany a eiio?ie? (?<0,001). A oeae ia??iae caa??aaany neeueiee iiceoeaiee ca’ycie i?ae iieacieeaie aeoeaiino? IOe (ai?no a ieo IAeA oa ON a oiiaao eoeueoo?e) oa e?euee?noth iiaeeo?eiaaieo EI o e?ia? c eiao?oe??ioii ei?aeyoe?? r=0,607 oa r=0,751 a?aeiia?aeii. Oaeei /eiii, ?acoeueoaoe aeaii? na??? aeine?aeaeaiue na?ae/aoue i?i oa, ui a oiiaao iaaei??iiai iaaeoiaeaeaiiy ON a i?aai?ci AOA aeieea? ia?aeiii ua aei iiyae o e?ia? aoa?iaaiieo oi?i EI. Iiaeeo?eaoe?y EI ia? neeaaeiee oa?aeoa? ? o?eueee /anoeiai aecia/a?oueny ?o ia?aeeniei ieeneaiiyi; inoaii? ?icaeaa?oueny o a?eueo a?aeaeaeai? no?iee ? noi?iaiaeaeo?oueny iiaeaeueoei c?inoaiiyi ?ioaineaiino? AOA. Ioaea, i?iaaaeai? aeine?aeaeaiiy aeicaieeee anoaiiaeoe, ui iniiaiei oi?aa?naeueiei iaoiaaiaoe/iei oaeoi?ii AOA oa aoa?ineea?ico ? ?icaeoie aoa?iaaiiino? ieacie aiane?aeie iiyae a i?e iiaeeo?eiaaieo EI. Aei /enea aaaeo/eo oaeoi??a iiaeeo?eaoe?? EI a?aeiineoueny ?icaeoie ieneaeaoeaiiai no?ano, iaei??th c iniiaieo i?e/ei yeiai ? aeoeaaoe?y IOe. A iiae?aieo oiiaao oe? ci?ie aeieeathoue ia?aeiii, a ii?ooaiiy iai?io EI oa ?icaeoie AOA iathoue aoi?eiiee oa?aeoa?. I?ioa i?e iaaei??iiio iaaeoiaeaeaii? a i?aai?ci aeciaaiiai ON ia?aeiiei ? ?acaeoie AOA c iiaeaeueoith iiaeeo?eaoe??th EI oa aoi?eiiith iiyaith ieneaeaoeaiiai no?ano a ?acoeueoao? aeoeaaoe?? IOe. Iacaaaeath/e ia oa, ui a oeeo oiiaao ia?aeeni? i?ioeane iathoue aoi?eiiee oa?aeoa?, aiie a cia/i?e i??? aecia/athoue iiaeaeueoa ia?inoaiiy aoa?iaaiiino? e?ia? oa ?icaeoie AOA. AENIIAEE 1. Iaea?eueo caeiiii??iei iaoai?ciii ?icaeoeo aoa?ineea?ico oa eiai ee?i?/ieo aea?aaeaio?a ? c?inoaiiy aoa?iaaiiiai iioaioe?aeo e?ia?, ui na?ae/eoue i?i cia/ou?noue inoaiiueiai ye aaaeo/iai iaoiaaiaoe/iiai iaoai?cio i?ioeano. 2. AOA ia ? oi?aa?naeueiei oaeoi?ii iaoiaaiaco aoa?ineea?ioe/iiai i?ioeano i?e ?ON; ae?aaeaia oa a??ia?aeia ca?eueoaiiy ai?noo caaaeueiiai ON o e?ia? a?aei?/aii o?eueee o 60-65% ianoaaeaieo oai?eo ia ?ON. 3. A?aenooi?noue i?yii? ei?aeyoe?eii? caeaaeiino? i?ae ai?noii caaaeueiiai ON o e?ia? oa nooiaiai aoa?iaaiiino? ieacie na?ae/eoue i?i oa, ui AOA ? a a?eueo?e i??? iaoiaaiaoe/iei, i?ae ao?ieia?/iei oaeoi?ii aoa?ineea?ico. 4. AOA o oai?eo ?ON ? a a?eueo?e i??? aoi?eiiei iaoiaaiaoe/iei oaeoi?ii aoa?ineea?ico ? iiaea ?icaeyaeaoenue ye ia?ea? aeniei? aeoeaiino? iaoai?ci?a, ui aecia/athoue ii?ooaiiy iaoaaie?cio EI. 5. Aoa?iaaii?noue ieacie o oai?eo ?ON aecia/a?oueny ia?o ca ana iiaeeo?eaoe??th EI a ?acoeueoao? ?icaeoeo ieneaeaoeaiiai no?ano oa iaeiie/aiiy o e?ia? i?ii?aeieo oa e?ioeaaeo i?iaeoeo?a IIE. 6. Ieneaeaoeaiee no?an, ui aeieea? ye i?e i?e?iaeiueiio ?icaeoeo caiaeueiiai i?ioeano, oae ? i?e eiai iiaeaethaaii? a oiiaao aenia?eiaioo, ? ?acoeueoaoii aeoeaaoe?? caiaeueieo ee?oei e?ia? ? i?eaiaeeoue aei cia/iiai ii?ooaiiy iai?io EI, ui i?iyaey?oueny i?aeaeuaiiyi aoa?iaaiiiai iioaioe?aeo ieacie oa caeiiii??iei ?icaeoeii o?aiceoi?ii? AOA. 7. Caeaaei?noue i?ae aeoeaaoe??th a?eueii?aaeeeaeueieo i?ioean?a oa ii?ooaiiyie iai?io EI i?aeoaa?aeaeo?oueny iinooiiaith ii?iae?caoe??th e?i?aeiiai niaeo?o e?ia? ye i?e niiioaiiiio cai?ioiueiio ?icaeoeo caiaeueieo ?aaeoe?e, oae ? i?ney i?iaaaeaii? aioeaaeoa??aeueii? aai aioeieneaeaioii? oa?ai??. 8. Ii?ooaiiy iai?io EI e?ia? i?ney ieneaeaoeaiiai no?ano iathoue caoyaeiee oa?aeoa?, ui ? iane?aeeii nainea?e?caoe?? nenoaie iaoaaie?cio e?i?ae?a aei iaae?aoi??a caiaeaiiy ? noai?th? oiiae aeey noiaoe?? aoaeoo ?yaeo iine?aeiaieo aieea?a. 9. I?e/eiii-iane?aeeiaa caeaaei?noue i?ae aeoeaaoe??th IOe e?ia?, i?aeaeuaiiyi ?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a oa ii?ooaiiyie iaoaaie?cio EI ia? caeiiii??iee oa?aeoa? ? anoaiiaeaia ye o oai?eo c ee?i?/ieie i?iyaaie aoa?ineea?ico oa o ae?oae c aino?eie caiaeueieie caoai?thaaiiyie, oae ? i?e aenia?eiaioaeueiiio iiaeaethaaii? aino?iai caiaeueiiai i?ioeano. 10. I?e aenia?eiaioaeuei?e ae?iaioa?i?e AOA ??aaiue ON o ieaci? c?inoa? ia?aeiii, oiae? ye iiyaa ?? aoa?iaaiieo aeanoeainoae ia? aoi?eiiee oa?aeoa?. A oeeo oiiaao ?icaeoie a?eueii?aaeeeaeueieo ?aaeoe?e ia ? aecia/ath/ei oaeoi?ii aoa?iaaiii? iiaeeo?eaoe?? EI e?ia?. 11. I?e oo?eiaii? oaa?ei ia aoa?iaaii?e ae??o? AOA ?icaeaa?oueny ii i?eioeeio ii?i/iiai eiea c iine?aeiaiei caeo/aiiyi ie?aieo iaoiaaiaoe/ieo iaoai?ci?a oa ?c no?ae/anoei c?inoaiiyi ??aiy caaaeueiiai ON o e?ia?. 12. A oiiaao ae?iaioa?ii? AOA aeoeaaoe?y IOe, ?ioaineo?eaoe?y a?eueii?aaeeeaeueieo i?ioean?a oa ia?aeenia aoa?iaaiia iiaeeo?eaoe?y EI iaaoaathoue caeiiii??iiai oa?aeoa?o ia a?aeaeaeaieo aoaiao ? yaeythoueny iaoai?ciaie iiaeaeueoiai ii?ooaiiy e?i?aeiiai iai?io oa i?ia?anoaaiiy AOA. 13. A?aoiaoth/e iaoiaaiaoe/io cia/ou?noue ieneaeaoeaieo i?ioean?a a aoa?iaaii?e iiaeeo?eaoe?? EI e?ia? oa ?icaeoeo AOA, aioeieneaeaoia oa?ai?y iiaeiia ?icaeyaeaoenue ye iaeaaaeeea?oee oeyo ia?aeiii? oa aoi?eiii? i?io?eaeoeee aoa?ineea?ico. I?aeoe/i? ?aeiiaiaeaoe?? 1. Aeey aecia/aiiy aeoeaiino? aoa?ineea?ioe/iiai i?ioeano oa ?eceeo i?ia?anoaaiiy aoa?ineea?ico o oai?eo ?ON aecia/aiiy caaaeueiiai ??aiy ON e?ia? aeioe?eueii ii?aeioaaoe c aecia/aiiyi ai?noo a e?ia? aoa?iaaiieo EI. 2. ??aaiue aoa?iaaiiino? ieacie iiaea aooe aeei?enoaiee aeey ae?aaiinoeee iayaiino? aoa?ineea?ioe/iiai i?ioeano a aeiee?i?/i?e noaae?? caoai?thaaiiy. 3. A??ia?aeiei i?eioeeiii aecia/aiiy iayaiino? oa ae?aaeaiino? aoa?iaaiieo ci?i EI e?ia? ? iaoiae a?ioanooaaiiy ieacie ca aeiiiiiaith eoeueoo?e ieoa/eo iae?ioaa?a. 4. Aeey aecia/aiiy iayaiino? ieneaeaoeaiiai no?ano ye iaoiaaiaoe/iiai oaeoi?o aoa?ineea?ico oa aeioe?eueiino? i?ecia/aiiy aioeieneaeaioii? oa?ai?? iaiao?aeii aecia/aoe ??aaiue aeoeaiino? IOe e?ia? oa ?? i?i- oa aioeieneaeaioiee iioaioe?ae. 5. A?aoiaoth/e iaoiaaiaoe/io cia/ou?noue ieneaeaoeaiiai no?ano a ?icaeoeo aoa?ineea?ico oa eiai ee?i?/ieo i?iya?a, aeioe?eueii aeei?enoiaoaaoe aioeieneaeaioio oa?ai?th aeey ia?aeiii? oa aoi?eiii? i?io?eaeoeee ?ON. Nienie iioa?eiaaieo i?aoeue ca oaiith aeena?oaoe?? 1. Oaeaaaa O.A., Oa?aiaiei A.I., Enaa/eeia E.I., O?aoye E.A., Na?aeaii I.A., A?aoonue A.A. Aeeiaieea eciaiaiee ooieoeeiiaeueiuo oa?aeoa?enoee yiaeioaeey e aeaaeeiiuoa/iuo eeaoie ninoaeia a oneiaeyo aeeeoaeueiie aeia?oieanoa?eiaiee // Oeceie. aeo?iae NNN? ei. E.I.Na/aiiaa.- 1990.- N8.- N.1055-1061. 2. Oaeaaaa O.A., Enaa/eeia E.I., O?aoye E.A. Iaoaieciu eciaiaiee ?aaeoeaiinoe ninoaeenoie noaiee i?e yenia?eiaioaeueiii aoa?ineea?ica // Aeia?oiie/aneay aieaciue, aoa?ineea?ic e ei?iia?iay iaaeinoaoi/iinoue.- Eeaa: Caei?ia”y.- 1991.- aui. 23.- N.90-95. 3. Oa?aiaiei A.I., Oeoeei N.I., Oaeaaaa O.A., Enaa/eeia E.I., A?aoonue A.A. Yooaeoeaiinoue caueou ninoaeenoie noaiee io aoa?ineea?ioe/aneiai iia?aaeaeaiey ?acee/iuie eaeueoeeaauie aioaaiienoaie // Iaoieiae/aneay oeceie. e yenia?ei. oa?aiey.- 1991.- N1.- N. 5-7. 4. A?aoonue A.A., Oaeaaaa O.A., Enaa/eeia E.I., Oeoeei N.I., Na?aeaiei I.A., Oa?aiaiei A.I. Oa?aeoa? e iaoaieciu eciaiaiee ?aaeoeaiinoe ninoaeenoie noaiee a oneiaeyo aeeeoaeueiie aeia?oieanoa?eiaiee // Iaoieiae/aneay oeceie. e yenia?ei. oa?aiey.-1991.-N5.-N.17-20. 5. Oa?aiaiei A.I., Oaeaaaa O.A., Enaa/eeia E.I., Oeoeei N.I., Na?aeaiei I.A., A?aoonue A.A. Aiaeii?ioaeoi?iay yooaeoeaiinoue ni/aoaiiiai eniieueciaaiey oei?enoiai iaaiey e aioeieneaeaioia a oneiaeyo aeeeoaeueiie AOA // Oeceie. aeo?iae AI Oe?aeiu.- 1993.- o.39, N1.- N.102-106. 6. Ei?ieaiei I.A., Oaeaaaa O.A., A?aoonue A.A. Caaeneiinoue iaaeaeo niaea?aeaieai a e?iae oieanoa?eia, aeoeaiinoueth ieneaeaoeaiuo i?ioeannia e aoa?iaaiiinoueth ieaciu o aieueiuo n ei?iia?iui aoa?ineea?icii // Oe?. ea?ae?ie. aeo?i. - 1995.- ?5.- N.50-54. 7. A?aoonue A.A., Ei?ieaiei I.A., Oaeaaaa O.A., Eiiaeianeee A.E. Iiiioeeou e iiiioeeoa?ii-o?iiaioeeoa?iia acaeiiaeaenoaea a iaoiaaiaca aoa?ineea?ica // Oe?. ea?ae?ie. aeo?i.- 1996.- N3.- N.55-60. 8. A?aoonue A.A., Oaeaaaa O.A., Ei?ieaiei I.A., O?aoye E.A., A?aoonue A.A. Aeoeaaoeey iiiioeeoia eae oaeoi? iiaeeoeeaoeee eeiii?ioaeaeia e?iae e aicieeiiaaiey aeia?oieanoa?eiaiee //Oe?. ea?ae?ie. aeo?i.-1996.-N5- 6.- N.83-87. 9. Oaeaaaa O.A. ?ieue iiiioeeoia a iaoiaaiaca aoa?ineea?ica. I.O/anoea iiiioeeoia e?iae a iiaeeoeeaoeee eeiii?ioaeaeia e aicieeiiaaiee eo aoa?iaaiiuo oi?i// Oe?. ea?ae?ie. aeo?i.- 1996.- N5-6.- N.112-118. 10. Oaeaaaa O.A. ?ieue iiiioeeoia a iaoiaaiaca aoa?ineea?ica. II. Iiiioeeou eae iaeeieaeiue oaeoi? aoa?iaaiaca //Oe?. ea?ae?ie. aeo?i.-1997.-N1.- N.72-77. 11. Oaea?aa O.A. I?e?iaea oa iaoai?cie iiaeeo?eaoe?? e?iii?ioa?ae?a i?e aeoeaaoe?? iiiioeeo?a // Oe?. ea?ae?ie. aeo?i.- 1997.- aei.II, N1.- N.82-85. 12. Oaeaaaa O.A., Ei?ieaiei I.A., A?aoonue A.A.,Oyaeeay A.A., A?aoonue A.A. Ino?ue ainiaeeoaeueiue i?ioeann eae oaeoi? iiaeeoeeaoeee eeiii?ioaeaeia e?iae e ?acaeoey aeia?oieanoa?eiaiee // AEo?i. AII Oe?aeiu.- 1997.- N3.- N.463-470. 13. Oaeaaaa O.A. Naineaeeecaoeey i?aaiecia e iiaoi?iui ainiaeeoaeueiui i?ioeannai e aiciiaeiinoue eoioeyoeee ia?ooaiee iaiaia eeiii?ioaeaeia e?iae // Oe?. ea?ae?ie. aeo?i.- 1997.- aei.II, N2.- N.84-86. 14. Oaeaaaa O.A. I?aaeoi?aaeaeaiea ?acaeoey aoa?iaaiiinoe ieaciu i?e ino?ii ainiaeaiee n iiiiuueth aioeieneaeaioiie oa?aiee // Oe?. ea?ae?ie. aeo?i.- 1997.- aei.II, N2.- N.87-89. 15. Oaeaaaa O.A., Ei?ieaiei I.A., A?aoonue A.A., Oyaeeay A.A., A?aoonue A.A. Ino?ue ainiaeeoaeueiue i?ioeann eae oaeoi? iiaeeoeeaoeee eeiii?ioaeaeia e?iae e ?acaeoey aeia?oieanoa?eiaiee// Oe?. ea?ae?ie. aeo?i.- 1997.- ?4.- N.48-53. 16. A?aoonue A.A., Oaea?aa O.A. ?ieue iiaeeoeeaoeee eeiii?ioaeiia a iaoiaaiaca aoa?ineea?ica // AEo?iae AII Oe?a?ie.- 1998.- O.4, ?2.- N.234-252. 17. Oaeaaaa O.A., O?aoye E.A., ?aaeaeianeay I.A., A?aoonue A.A. Iaoiaaiac aeia?oieanoa?eiaiee o e?ieeeia i?e aeeeoaeueiii i?aauaaiee ia aoa?iaaiiie aeeaoa // Oe?. ea?ae?ie. aeo?i.- 1999.- ?1.- N.52-56. 18. A?aoonue A.A., Oaea?aa O.A., ?aaeaeianueea I.A., O?aoye ?.A. ?ieue nenoaiiiai caiaeueiiai i?ioeano a aoa?iaaii?e iiaeeo?eaoe?? e?iii?ioa?i?a oa ?icaeoeo a?ia?oieanoa?eiai?? //O?c?ieia?/iee aeo?i.- 1999.- ?1/2.- N.40-49. 19. Talaeva T., Tretiac I., Sergienko O., Bratus V.Generalization of vascular wall reactivity changes after local denudation//Europ.Heart J.- 1991.-Vol.12.- P.117. 20. Talaeva T., Bratus V., Tretiak I. Vasoactive and antiplatelet properties of vascular endothelium in hypercholesterolemia and early atherosclerosis // Europ. Heart J.- 1993.- Vol. 14.- absrt. suppl.- P. 395. 21. A?aoonue A.A., Oaeaaaa O.A., Ei?ieaiei I.A., Eiiaeianeee A.I. Naiaiaeii?aaeeeaeueiay aeoeaiinoue iiiioeeoia e?iae aieueiuo n ei?iia?iui aoa?ineea?icii // Oe?. ea?ae?ie. aeo?i.- 1996.- aeiiiai. aei N3.- Iaoa??aee Y eiia?ano ea?ae?ieia?a Oe?a?ie.- N.37. 22. A?aoonue A.A., Oaeaaaa O.A., O?aoye E.A., ?aaeaeianeay I.A. Iniaaiiinoe iaoiaaiaca aeia?oieanoa?eiaiee i?e niiioaiiii e yenia?eiaioaeueiii aoa?ineea?ica // Oe?. ea?ae?ie. aeo?i.- 1998.- ?10 (aeiaeaoie).- N.30. AIIOAOe?ss Oaea?aa O.A. Iiaeeo?eiaai? e?iii?ioa?ie: iaoai?cie ooai?aiiy oa ?ieue a aoa?iaaiac?.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y.- Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea IIC Oe?a?ie, Ee?a, 1998. Aeena?oaoe?y ia? ee?i?ei-aenia?eiaioaeueiee oa?aeoa? ? i?enay/aia aecia/aiith iaoai?ci?a oa cia/ouino? aoa?iaaiii? iiaeeo?eaoe?? e?iii?ioa?i?a e?ia? ye o ?icaeoeo a?ia?oieanoa?eiai??, oae ? a yeino? naiino?eiiai iaoiaaiaoe/iiai oaeoi?o aoa?ineea?ico. Aea/aia caeaaei?noue i?ae aeoeaaoe??th iiiioeeo?a, ?ioaineai?noth i?ioean?a ia?aeeniiai ieeneaiiy a e?ia?, iiyaith a i?e iiaeeo?eiaaieo e?iii?ioa?i?a oa eiioeaio?aoe??th caaaeueiiai oieanoa?eio. Anoaiiaeaii, ui oi?aa?naeueiei iaoiaaiaoe/iei iaoai?ciii aoa?ineea?ico ? ia ?icaeoie a?ia?oieanoa?eiai??, a c?inoaiiy aoa?iaaiiino? ieacie, yea aecia/a?oueny iiaeeo?eaoe??th e?iii?ioa?i?a e?ia? aiane?aeie ieneaeaoeaiiai no?ano. Inoaii?e niinoa??aa?oueny ye o oai?eo ?ON oa i?e i?e?iaeiiio ?icaeoeo caiaeueiiai i?ioeano, oae ? i?e eiai iiaeaethaaii? a oiiaao aenia?eiaioo, ? ? ?acoeueoaoii aeoeaaoe?? caiaeueieo ee?oei e?ia?, ia?o ca ana - iiiioeeo?a. I?e aenia?eiaioaeuei?e ae?iaioa?i?e a?ia?oieanoa?eiai?? ??aaiue oieanoa?eio a ieaci? c?inoa? ia?aeiii, oiae? ye iiyaa ?? aoa?iaaiieo aeanoeainoae ia? aoi?eiiee oa?aeoa?. A oeeo oiiaao ?icaeoie ieneaeaoeaiiai no?ano ia ? aecia/ath/ei oaeoi?ii aoa?iaaiii? iiaeeo?eaoe?? e?iii?ioa?i?a e?ia?. Eeth/ia? neiaa: aoa?ineea?ic, caiaeaiiy, a?ia?oieanoa?eiai?y, iiaeeo?eiaai? e?iii?ioa?ie, iiiioeeoe, ieneaeaoeaiee no?an. SUMMARY Talaeva T.V. Modified lipoproteins: the mechanisms of formation and role in atherogenesis.- Manuscript. Thesis for a doctor”s degree in medicine by speciality 14.01.11 - cardiology.- Ukrainian Research Institute of Cardiology by acad.M.D.Strazhesko, Ukrainian Ministry of Health, Kiyev, 1998. The thesis has clinically - experimental character and is devoted to the elucidation of mechanisms and importance of blood lipid atherogenic modification both in the development of hypercholesterolemia and as an independent pathogenic factor of atherosclerosis. In the study there were expored the links between the activity of circulating monocytes, the intensity of peroxidative processes in blood, the appearence of the modified lipoprteins in it, and the concentration of blood total cholesterol. It was shown that the most universal pathogenic mechanism of atherosclerosis in not a hypercholesterolemia development but the increase of blood atherogenity that is determined by blood lipoproteins modification. The leading factor of the oxidative stress that appears in patients with coronary heart disease, in spontaneous development of the inflammative process and in its experimental modelling is the blood inflammatory cell activation, first of all - monocytes. It results in activation of free-radical processes with following distinct disturbances of the blood liproproteins metabolism which lead to increase of blood atherogenic potential and to the regular development of the transient hypercholesterolemia. On the contrary to spontaneous hypercholesterolemia in patients with coronary heart disease the level of cholesterol in blood in experimental hypercholesterolemia was shown to increase primarily and the appearence of blood atherogenity is the second event. In these conditions oxidative stress development is not the determining factor of blood lipoproteins atherogenic modification. Key words: atherosclerosis, inflammation, hypercholesterolemia, lipoproteins, modified lipoproteins, monocytes, oxidative stress. AIIIOAOeEss Oaeaaaa O.A. Iiaeeoeoee?iaaiiua eeiii?ioaeiu: iaoaieciu ia?aciaaiey e ?ieue a aoa?iaaiaca.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey.- Oe?aeineee iao/ii-enneaaeiaaoaeueneee einoeooo ea?aeeieiaee ei.aeaae.I.Ae.No?aaeanei IC Oe?aeiu, Eeaa, 1998. Aeenna?oaoeey eiaao eeeieei-yenia?eiaioaeueiue oa?aeoa? e iinayuaia ii?aaeaeaieth iaoaieciia e cia/eiinoe aoa?iaaiiie iiaeeoeeaoeee eeiii?ioaeiia e?iae eae a ?acaeoee aeia?oieanoa?eiaiee, oae e a ea/anoaa naiinoiyoaeueiiai iaoiaaiaoe/aneiai oaeoi?a aoa?ineea?ica. Eeeie/aneee o?aaiaio ?aaiou iniiaai ia ?acoeueoaoao enneaaeiaaiey 127 aieueiuo EAN e 20 aieueiuo n ainiaeeoaeueiuie caaieaaaieyie i?aaiia aeuoaiey eioaeoeeiiiie i?e?iaeu. A oneiaeyo yenia?eiaioa aini?iecaaaeaii 2 iiaeaee nenoaiiiai ainiaeeoaeueiiai neiae?iia n iiiiuueth aioo?eaaiiiai aaaaeaiey e?ieeeai acaane eaoaeniuo iee?inoa? e ie?iaaiaea, a oaeaea eeanne/aneay iiaeaeue aeeiaioa?iie aeia?oieanoa?eiaiee. Eco/aia caaeneiinoue iaaeaeo aeoeaaoeeae oee?eoee?othueo iiiioeeoia, eioaineaiinoueth i?ioeannia ia?aeeniiai ieeneaiey a e?iae, iiyaeaieai a iae iiaeeoeoee?iaaiiuo eeiii?ioaeiia e eiioeaio?aoeeae iauaai oieanoa?eia e?iae. Onoaiiaeaii, /oi iaeaieaa oieaa?naeueiui iaoiaaiaoe/aneei iaoaieciii aoa?ineea?ica yaeyaony ia ?acaeoea aeia?oieanoa?eiaiee, a ia?anoaiea aoa?iaaiiinoe ieaciu, eioi?ay a cia/eoaeueiie ia?a ii?aaeaeyaony iiaeeoeeaoeeae eeiii?ioaeiia e?iae. Iiyoiio aeia?oieanoa?eiaieth iaeuecy, ii-aeaeeiiio, ?anniao?eaaoue eae oieaa?naeueiue oaeoi? e iaiin?aaenoaaiioth i?e/eio ?acaeoey aoa?ineea?ica. Iiauoaiiia niaea?aeaiea oieanoa?eia a e?iae nei?aa iineo aoi?e/iue oa?aeoa? e io?aaeaao aunieoth aeoeaiinoue iaoaieciia, ii?aaeaeythueo ia?ooaiey iaoaaieecia eeiii?ioaeiia. E /eneo yoeo iaoaieciia ioiineony i?aaeaea anaai ?acaeoea ieneaeaoeaiiai no?anna n iaeiieaieai a e?iae i?iiaaeooi/iuo e eiia/iuo i?iaeoeoia ia?aeeniiai ieeneaiey eeieaeia. Aaaeouei oaeoi?ii ieneaeaoeaiiai no?anna, aicieeathuaai eae o aieueiuo EAN e i?e anoanoaaiiii ?acaeoee ainiaeeoaeueiiai i?ioeanna, oae e i?e aai iiaeaee?iaaiee a oneiaeyo yenia?eiaioa, yaeyaony aeoeaaoeey ainiaeeoaeueiuo eeaoie e?iae, i?aaeaea anaai - iiiioeeoia. ?acoeueoaoii aicieeathueo naiaiaeii?aaeeeaeueiuo i?ioeannia yaeyaony au?aaeaiiia ia?ooaiea iaiaia eeiii?ioaeiia e?iae, /oi i?iyaeyaony iiauoaieai aa aoa?iaaiiiai iioaioeeaea e caeiiiia?iui ?acaeoeai o?aiceoi?iie aeia?oieanoa?eiaiee. Aicieeathuea a ?acoeueoaoa ieneaeaoeaiiai no?anna ia?ooaiey iaiaia eeiii?ioaeiia e?iae eiatho caoyaeiie oa?aeoa?, /oi nicaeaao oneiaey aeey naineaeeecaoeee nenoaiu iaoaaieecia eeieaeia e iaaeeaoi?ai ainiaeaiey e noiiaoeee yooaeoa ?yaea iineaaeiaaoaeueiuo aicaeaenoaee, n aiciiaeiinoueth ?acaeoey onoie/eaie aeia?oieanoa?eiaiee. Iieacaia aiciiaeiinoue i?aaeoi?aaeaeaiey aicieeathueo eciaiaiee ia yenia?eiaioaeueiie iiaeaee nenoaiiiai ainiaeeoaeueiiai neiae?iia n iiiiuueth aioeieneaeaioiie oa?aiee. A aeenna?oaoeee ii?aaeaeaii, /oi, a ioee/ea io niiioaiiie aeia?oieanoa?eiaiee o aieueiuo EAN, i?e yenia?eiaioaeueiie aeeiaioa?iie aeia?oieanoa?eiaiee o?iaaiue oieanoa?eia a ieacia ia?anoaao ia?ae/ii, oiaaea eae iiyaeaiea aa aoa?iaaiiuo naienoa eiaao aoi?e/iue oa?aeoa?. A yoeo oneiaeyo ?acaeoea ieneaeaoeaiiai no?anna ia yaeyaony ii?aaeaeythuei oaeoi?ii aoa?iaaiiie iiaeeoeeaoeee eeiii?ioaeiia e?iae. Aeoeaaoeey oee?eoee?othueo iiiioeeoia n ?acaeoeai naiaiaeii?aaeeeaeueiuo i?ioeannia e aoa?iaaiiay iiaeeoeeaoeey eeieaeia a oneiaeyo aoa?iaaiiie aeeaou i?eia?aoatho caeiiiia?iue oa?aeoa? ia ioaeaeaiiuo yoaiao enneaaeiaaiey e yaeythony aaaeoueie iaoaieciaie ion?i/aiiuo ia?ooaiee eeieaeiiai iaiaia e i?ia?anne?iaaiey aeia?oieanoa?eiaiee. A ?acoeueoaoa i?e aeeeoaeueiii ecauoi/iii iinooieaiee a i?aaieci yeciaaiiiai oieanoa?eia aeia?oieanoa?eiaiey ?acaeaaaony ii i?eioeeio ii?i/iiai e?oaa n iineaaeiaaoaeueiui aeeth/aieai ioaeaeueiuo iaoiaaiaoe/aneeo iaoaieciia e ni nooiai/aoui aic?anoaieai o?iaiy iauaai oieanoa?eia a e?iae. O/eouaay yoeieiae/aneoth cia/eiinoue ieneaeaoeaiuo i?ioeannia a aoa?iaaiiie iiaeeoeeaoeee eeiii?ioaeiia e?iae e ?acaeoee aeia?oieanoa?eiaiee, aioeieneaeaioiay oa?aiey aeieaeia ?anniao?eaaoueny eae aaaeiaeoee iooue ia?ae/iie e aoi?e/iie i?ioeeaeoeee aoa?ineea?ica. Eeth/aaua neiaa: aoa?ineea?ic, ainiaeaiea, aeia?oieanoa?eiaiey, eeiii?ioaeiu, iiaeeoeoee?iaaiiua eeiii?ioaeiu, iiiioeeou, ieneaeaoeaiue no?ann. IA?AE?E OIIAIEO IICIA*AIUe AOA - a?ia?o?eae?oea?eaeai?y AOA - a?ia?oieanoa?eiai?y ?OE - ?iaeoeiaaia oai?ethi?ianoeaioe?y ?ON - ?oai?/ia oai?iaa na?oey EI - e?iii?ioa?ie EIAU - e?iii?ioa?ie aeniei? u?eueiino? EIAeIU - e?iii?ioa?ie aeoaea iecueei? u?eueiino? EIIU - e?iii?ioa?ie iecueei? u?eueiino? IAeA - iaeiiiaee aeeaeueaeaa?ae II - ieoa/? iae?ioaae IOe - iiiioeeoe IIE - ia?aeenia ieeneaiiy e?i?ae?a IO - iieaciee oaaioeeoico NOE - niiioaiia oai?ethi?ianoeaioe?y OA - o?eae?oea?eaee O* - oaaioeeoa?ia /enei OE - oai?ethi?ianoeaioe?y ON - oieanoa?ei A? - na?oeinoia ?iaeoeiaaii? oai?ethi?ianoeaioe?? ?max - ?ioaineai?noue iaeneiaeueiiai na?o?iiy ?iaeoeiaaii? oai?ethi?ianoeaioe?? Imin - ?ioaineai?noue i?i?iaeueiiai na?o?iiy ?iaeoeiaaii? oai?ethi?ianoeaioe?? PAGE 32

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