I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Oa?e?anueeee iaoeiai-aeine?aeiee ?inoeooo i?e?ia?ieia??

oa ?ioiieia?? ?i. ?.?. Ia/ieeiaa

Ia i?aaao ?oeiieno

N?AeAE Ethaeieea Aieiaeeie??aia

OAeE:618.13-002.2-097

I?e?ia?ieia?/i? oa ?ioiieia?/i? aniaeoe o?ii?/iiai ?aoeeaeeaoth/iai
naeuei?iaiioi?eoo

03.00.07 – i?e?ia?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai??
I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie

IAOEIAEE EA??AIEE: aeieoi? iaaee/ieo iaoe, i?ioani? Neaei?/oe ?ai?
Eineiiae/, Aoeiaeinueea aea?aeaaia iaaee/ia aeaaeai?y, caa?aeoaa/
eaoaae?e ee?i?/ii? ?ioiieia??, aea?aieia?? oa aiaeie?eiieia??

IAOEIAEE EIINOEUeOAIO:

eaiaeeaeao iaaee/ieo iaoe, aeioeaio Aeaeiaea Nayoineaa ?aaai?eiae/,
Aoeiaeinueea aea?aeaaia iaaee/ia aeaaeai?y, aeioeaio eaoaae?e
i?e?ia?ieia?? oa a??onieia??

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Aaae/ ?aaai
Ieoaeeiae/, Oa?e?anueeee iaoeiai-aeine?aeiee ?inoeooo i?e?ia?ieia?? oa
?ioiieia?? ?i. ?.?. Ia/ieeiaa IIC Oe?a?ie, caa. eaai?aoi???th
e?aiaeueieo ?ioaeoe?e

aeieoi? iaaee/ieo iaoe, i?ioani? Eeeiithe Na?a?e ?aaiiae/,
Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss. Ai?aa/aanueeiai,
caa?aeoaa/ eaoaae?e i?e?ia?ieia??, a??onieia?? oa ?ioiieia?? c eo?nii
iaaee/ii? a?ieia??

I?ia?aeia onoaiiaa : Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai IIC
Oe?a?ie, i. Ee?a

Caoeno a?aeaoaeaoueny “20” ea?oiy 1999 ?ieo i 1200 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.618.01 Oa?e?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo i?e?ia?ieia?? oa ?ioiieia?? ?i. ?.?.
Ia/ieeiaa ca aae?anith 310057, i. Oa?e?a, aoe. Iooe?inueea, 14

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oa?e?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo i?e?ia?ieia?? oa ?ioiieia?? ?i.?.?.
Ia/ieeiaa ca aae?anith 310057, i. Oa?e?a, aoe. Iooe?inueea, 14

Aaoi?aoa?ao ?ic?neaiee “____”_________________ 1999 ?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe
O.?. Eieyaea

Aeooaeuei?noue oaieAeooaeuei?noue oaie

A inoaii? ?iee i?iaeaiai caoai?thaaiue, ui ia?aaeathoueny noaoaaei
oeyoii, iaaea?oueny aaeeea cia/aiiy. C?inoa? aaaeeea?noue aea/aiiy
iniaeeainoae iaoieia?/ieo, i?e?ia?ieia?/ieo, ai?aeai?ieia?/ieo oa
?ioiieia?/ieo i?ioean?a, ?ic?iaee iaoiae?a ae?aaiinoeee, e?eoaaiiy oa
i?io?eaeoeee oai?ia, ine?eueee aiie aieeaathoue ia ia?iaeaeoaai?noue,
ia?aa?a aaa?oiino?, noai ieiaeo, iiaiia?iaeaeaieo, ia?eiaoaeueio ?
aeeoy/o eaoaeuei?noue.

O?ii?/iee ?aoeeaeeaoth/ee naeuei?iaiioi?eo (O?N) ca iioe?ai?noth ?
niaeo?ii i?iya?a oneeaaeiaiue iin?aea? i?ia?aeia i?noea na?aae oai?ia
a?iaeieia?/iiai i?io?eth [Aiaeyaeeia A.E., Niaoiee A.I., Ooieeiae/ E.A.,
1990]. O?ii?caoe?y naeuei?iaiioi?eoo ? iane?aeeii iiai?noth
iaaeie?eiaaieo aino?eo oi?i, canoinoaaiiy ia?aoe?iiaeueii? ao?io?iiii?
oa?ai?? oa ?i. [Eoeaeia A.E., Aeoeyaaa A.I., 1995].

Canoinoaaiiy aioea?ioee?a oa aioeaaeoa??aeueieo o?i?ioa?aiaaoe/ieo
i?aia?ao?a i?ecaaei aei ci?ie aeaeiaiai neeaaeo i?e?ioei?e i?oae ?
oea?a?eaeueiiai ai?noo, ?? aioea?ioeei/ooeeaino? oa a??oeaioiino?, ui
ni?eyei aoeiia?e iai?oanoaoe?? caoai?thaaiiy.

E?eoaaiiy oai?eo ia O?N iia’ycaii c ?yaeii o?oaeiiu?a. Aieiaia ?ieue o
e?eoaaii? oe??? iaoieia?? iaeaaeeoue ao?io?iii?e aioea?ioeeioa?ai??.
Iacaaaeath/e ia oa, ui a?naiae o?i?ioa?aiaaoe/ieo i?aia?ao?a iino?eii
iiiiaith?oueny iiaeie aenieiaoaeoeaieie caniaaie, a ee?i?/i?e
a?iaeieia?/i?e i?aeoeoe? niinoa??aa?oueny i?ioean oaeaeeiai ?icaeoeo
?acenoaioiino? aei e?e?a i?ney ei?ioeiai ia??iaeo ?o oni?oiiai
aeei?enoaiiy. Oiio iiooe oeyo?a iiaeieaiiy aioea?ioeei?acenoaioiino? oa
i?aeaeuaiiy aoaeoeaiino? iaoiaaiaoe/ii? oa?ai?? O?N ? iaei??th c
aeooaeueieo i?iaeai iaaeeoeeie. Iaeiae, aac ?icoi?iiy iaoai?ci?a
?icaeoeo oe??? iaoieia?? ?ai?iaeoeoeaieo i?aai?a o ae?iie iaiiaeeeai
ciaeoe i?aeoiaee aei oaeineiiaeaiiy iaoiae?a e?eoaaiiy (Oaiaea?ia A.A.,
1988).

O oie aea /an iaaeinoaoiuei iaoeiai iaa?oioiaai? iaoiaee oa?ai?? O?N
iiaeie ?ioiio?iiieie i?aia?aoaie, a oaeiae ?ioii-eaai?aoi?ia ioe?iea
i?ecia/aiiy iiaeo ?ioiio?iiieo i?aia?ao?a. Aii??e/iee i?aeo?ae iiaea
neiii?iiaooaaoe naio ?aeath aeei?enoaiiy ?ioiio?iiieo i?aia?ao?a ?
i?ecaanoe a ?yae? aeiaaee?a aei iia??oaiiy ee?i?/iiai ia?aa?ao
caoai?thaaiiy.

Aeooaeuei?noue aeine?aeaeaiue aecia/a?oueny oaeeie iioeaaie:
iaie?aei?noue, ui iaoiiaeaia O?N, ci?ie aeaeiaiai neeaaeo caoaeiee?a
caoai?thaaiiy, iecueeee oa?aiaaoe/iee iioaioe?ae canoiniaoaaieo
i?aia?ao?a ? ?acii c oei, iayai?noth aeinyaiaiue o aaeoc? ?ioiieia??,
ye? aeicaieythoue i?iaiaeeoe aea/aiiy iaoai?ci?a ii?ooaiiy nenoaie
ianiaoeeo?/iiai ? niaoeeo?/iiai ?ioiiiai i?ioe?ioaeoe?eiiai caoenoo oa
oe?ieeo iiaeeeainoae, ui a?aee?eaathoueny caaaeyee oeei aeinyaiaiiyi o
ca’yceo c aeei?enoaiiyi no/anieo ?ioiio?iiieo i?aia?ao?a.

Ca’ycie oaie aeena?oaoe?? c aea?aeaaieie /e aaeocaaeie iaoeiaeie
i?ia?aiaie

?iaioa aeeiioaaeanue o eaai?aoi??? ee?i?/ii? i?e?ia?ieia?? eaoaae?e
ee?i?/ii? ?ioiieia??, aea?aieia?? oa aiaeie?eiieia?? Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai?? I?ienoa?noaa ioi?iie caei?ia’y Oe?a?ie a
?aieao oaie «I?e?iaeieia?y oianoi? eeoee o oai?eo ??ciiai a?eo ia
oeoe?iaee ae?aaao oa o?ii?/i? ianiaoeeo?/i? caoai?thaaiiy eaaaiue» ca
ieaiaie iaoeiaeo ?ia?o AAeIA, ?a?no?aoe?eiee ? 0197V015106.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Aea/eoe aeieia?/i? ia?aiao?e
i?e?ia?ioeaiico oea?a?eaeueiiai ai?noo a ae?iie, oai?eo ia O?N a ia??iae
caaino?aiiy, anoaiiaeoe i?ia?aeieo caoaeiee?a caiaeueiiai i?ioeano oa ?o
aioea?ioeei/ooeea?noue caeaaeii a?ae naciiieo o?iii?eoi?a, a oaeiae
aeine?aeeoe iniaeeaino? ooieoe?iioaaiiy nenoaie ?ioi?oaoo caeaaeii a?ae
i?ia?aeieo caoaeiee?a aeey iiaeaeueoi? ?ic?iaee ao?io?iiii? oa?ai?? oa
iiaeeeaino? aeei?enoaiiy ?ioiio?iiieo i?aia?ao?a.

Caaaeaiiy aeine?aeaeaiiy. 1. Aea/eoe aeaeiaee neeaae i?e?ioei?e
oea?a?eaeueiiai ai?noo o oai?eo ia O?N caeaaeii a?ae naciiieo
o?iii?eoi?a.

2. Aeine?aeeoe e?euee?ni? iieacieee anioe?aio?a, ui ia?nenoothoue o
oea?a?eaeueiiio ai?no? oai?eo ia O?N, c iaoith aecia/aiiy i?ia?aeiiai
caoaeieea caiaeueiiai i?ioeano ?ai?iaeoeoeaieo i?aai?a ae?iie
ae?oi?iaeiiai a?eo.

3. I?iaanoe aea/aiiy /ooeeaino? ee?i?/ieo ooai?a-caoaeiee?a O?N aei
aioeaaeoa??aeueieo i?aia?ao?a ? aeoeaiino? inoaii?o caeaaeii a?ae
naciiieo o?iii?eoi?a.

4. Aecia/eoe ooieoe?iiaeueiee noai ianiaoeeo?/iiai i?ioe?ioaeoe?eiiai
caoenoo i?aai?cio oai?eo ia O?N caeaaeii a?ae i?ia?aeiiai caoaeieea
caiaeueiiai i?ioeano.

5. Ioe?ieoe ??aaiue ooieoe?iioaaiiy ?ioiii? nenoaie oai?eo ia O?N a
ia??iae caaino?aiiy caeaaeii a?ae i?ia?aeiiai caoaeieea.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Io?eiai? iia? aeai? na?ae/aoue
i?i oa, ui O?N noi?iaiaeaeo?oueny ia?nenoaioe??th a oea?a?eaeueiiio
ai?no? oa o ai?no? caaeiueiai neeai?iiy i?oae anioe?aoe?e iaoiaaiieo oa
oiiaii iaoiaaiieo aa?iaieo ? aiaa?iaieo aaeoa??e, ae??aeaeaeiiiae?aieo
a?ea?a ?iaeo Candida, aaa?iaeueieo o?eoiiiiaae oa o?aaieaci, ui
iaeaaeaoue aei 25 oaeniiii?/ieo a?oi.

I?e?ii?aai?cie, ui iathoue e?eoe/io (5,0 lg EOI/ie) eiioeaio?aoe?th a
oea?a?eaeueiiio ai?no?, ne?ae aaaaeaoe i?ia?aeieie caoaeieeaie, ui
oi?iothoue oyaee?noue caiaeueiiai i?ioeano ? aeeeeeathoue iaai? ci?ie a
nenoai? ?ioi?oaoo.

I?iaaaeaii aiae?c aeyaeaiiy iaoiaaiieo oa oiiaii-iaoiaaiieo
i?e?ii?aai?ci?a caeaaeii a?ae naciio, a oaeiae caeaaei?noue aeoeaiino?
aioei?e?iaieo i?aia?ao?a a?aeiinii i?ia?aeieo caoaeiee?a caiaeueiiai
i?ioeano a?ae naciiieo o?iii?eoi?a.

Iniiaieie caoaeieeaie caiaeueiiai i?ioeano a no/anieo oiiaao o ae?iie,
oai?eo ia O?N, ? aiiieie (32,12%), aioa?iaaeoa??? (30,04 %), cieioenoee
noao?eieie (22,93 %), aiaa?iai? anii?iaaii? aaeoa?i?aee ? iaioieie
(13,07%), C. albicans (1,54%) ? i?iaaiiee no?aioieie (0,27%).

Io?eiai? iia? eiiieaeni? aeai?, ye? oa?aeoa?ecothoue noai ianiaoeeo?/ieo
oa niaoeeo?/ieo ?ioiieo oaeoi??a i?ioe?ioaeoe?eiiai caoenoo i?aai?cio
ae?iie, oai?eo ia O?N. O oai?eo oi?io?oueny aoi?eiia ?ioiia
iaaeinoaoi?noue ca ?aooiie ciaioaiiy aaniethoii? oa a?aeiinii?
e?eueeino? O-e?ioioeeo?a, ?ioii?aaoeyoi?ieo ee?oei, a oaeiae ii?ooaiiy
ooieoe?? A-nenoaie e?ioioeeo?a, cieaeaiiy oaaioeeoa?ii? aeoeaiino?,
caeaoiino? aei caoaaoo i?e?ii?aai?ci?a oaaioeeooth/eie ee?oeiaie, a
oaeiae ciaioaiiy oeo?o eiiieaiaioa. Oa?aeoa? ci?i iieaciee?a nenoaie
?ioi?oaoo caeaaeeoue a?ae i?ia?aeiiai caoaeieea caiaeueiiai i?ioeano.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. I?iaaaeaia eiiieaenia ioe?iea
aeaeiaiai oa e?euee?niiai neeaaeo iaoiaaiieo oa oiiaii iaoiaaiieo
aa?iaieo oa aiaa?iaieo aaeoa??e ? C.albicans caeaaeii a?ae naciiieo
o?iii?eoi?a. Anoaiiaeaii, ui aiiieiee /ano?oa ? caoaeieeaie caiaeueiiai
i?ioeano ae?oeo, aaniith oa ainaie; cieioeno? noao?eieiee — ainaie ?
aceieo; aioa?iaaeoa??? (aioa?iiaoiaaii? oa aioa?ioieneaaii? aoa?eo?? oa
?i.) — ae?oeo ? ainaie; aaeoa?i?aee ? iaioieie — aaniith ? ainaie.

I?aia?aoaie aeai?o ao?io?iiii? oa?ai?? o?ii?/ii? aiii?a?, oneeaaeiaii?
O?N, ? aaioai?oeei ? oeaoacie?i, a ie?aieo aeiaaeeao- oeaoaoien?i. Aeey
e?eoaaiiy O?N, iaoiiaeaiiai noao?eieieaie, ainaie aeioe?eueii
aeei?enoiaoaaoe oeaoacie?i ? aaioai?oeei, ceiith — aaioai?oeei,
oeaoacie?i ? oeaoaoien?i.

I?e O?N, coiiaeaiiio aoa?eo?yie, ?aeiiaiaeiaaii i?iaiaeeoe ao?io?iiio
oa?ai?th iie?i?eneiii, aaioai?oeeiii, oo?aa?iii i?ioyaii anueiai ?ieo, a
i?e caiaeueiiio i?ioean?, aeeeeeaiiio aaeoa?i?aeaie aeioe?eueii aei
ao?io?iiii? oa?ai?? aeeth/eoe oei?aioai?eie, ea?aai?oeee?i, oeaoaeio?i,
e?ieii?oeei ? iie?i?enei; eiee i?ia?aeiei caoaeieeii ? iaioieie —
oeaoacie?i, oeaoaoien?i ? e?ieii?oeei.

I?ioea?eaeiaei i?aia?aoii aeai?o aeey e?eoaaiiy O?N, iaoiiaeaiiai C.
albicans, ? aeaeaiaoienei, aiinaio, aioeooia?i ? i?ci?ae.

I?iaaaeaia ioe?iea nenoaie ?ioi?oaoo o oai?eo ia O?N c aecia/aiiyi
ooieoe?iiaeueiiai noaio, aaniethoii? oa a?aeiinii? e?eueeino? O-, A- ?
I-e?ioioeeo?a, ?ioii?aaoeyoi?ieo ee?oei, aeicaiey? aecia/eoe eaiee
nenoaie ?ioi?oaoo, ui iio?aaothoue ?ioii?aaa?e?oaoe??. Aeyaeaia
cieaeaiiy aaniethoieo oa a?aeiinieo iieaciee?a O-eaiee nenoaie ?ioi?oaoo
aeicaiey? ?aeiiaiaeoaaoe aeei?enoaiiy ?ioiio?iiieo cania?a oeaio?aeueii?
ae?? — i?aia?ao?a oeiona.

Ii?ooaiiy ooieoe?? A-e?ioioeeo?a aei nae?aoe?? ?ioiiaeiaoe?i?a iniiaieo
eean?a iio?aao? aeei?enoaiiy i?aia?ao?a, ui aieeaathoue ia A-eaieo
(i??eii?aee oa ?i.)

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeothoueny a i?aeoeeo ?iaioe
e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a i. *a?i?aoe? oa aeei?enoiaothoueny
a eaeoe?yo ? ia i?aeoe/ieo caiyooyo ia eaoaae?? aeooa?noaa ?
a?iaeieia??, eaoaae?? i?e?ia?ieia?? oa a??onieia?? Aoeiaeinueei?
aea?aeaaii? iaaee/ii? aeaaeai??.

Iniaenoee aianie caeiaoaa/a. Aeena?oaio noai?eea iaoiaeieia?/io iniiao
?iaioe, aaeaeaaoio iao? oa caaaeaiith aeena?oaoe??. Naiino?eii
i?iaiaeeea aaeoa??ieia?/ia, i?eieia?/ia oa i?e?ineii?/ia aeine?aeaeaiiy
aeine?aeiiai iaoa??aeo. I?iaaea o an?o aeiaaeeao aecia/aiiy oa
?aeaioeo?eaoe?th aa?iaieo oa aiaa?iaieo aaeoa??e, a?ea?a, o?eoiiiiaae.

?ioii-eaai?aoi?i? aeine?aeaeaiiy (?ioiieia?/i? oanoe ?-?? ??ai?a)
aeeiiaii ni?eueii ?c ni?a?ia?oieeaie ?ioiieia?/ii? eaai?aoi???
*a?i?aaoeueeiai iaeaniiai ae?aaiinoe/iiai oeaio?o (caa. eaai?aoi???th
A.A. Oaa?eianueea) ? eaoaae?e ee?i?/ii? ?ioiieia??, aea?aieia?? oa
aiaeie?eiieia??. Iniaenoi i?iaaaeaia noaoenoe/ia ia?iaea oa aiae?c
io?eiaieo ?acoeueoao?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? ?acoeueoaoe oa iieiaeaiiy
aeena?oaoe?eii? ?iaioe aoee iia?aeiieai? oa iaaiai?ai? ia eiioa?aoe?yo,
c’?caeao oa neiiic?oiao:

— neiiic?oi “Neioac, aenia?eiaioaeueia aea/aiiy oa ee?i?/ia canoinoaaiiy
/aoaa?oeiieo aiii??aeo niieoe” i. *a?i?aoe?, aeiaoaiue, 1995 ?.;

— Oe?a?inueei-oaaaenueeee neiiic?oi “Aeooaeuei? ieoaiiy iaaee/ii?
aeiiiiiae ianaeaiith” i. *a?i?aoe? — Anhelholm (Svirige) aa?anaiue, 1996
?.;

— ia?oa iaoeiai-i?aeoe/ia i?aeia?iaeia eiioa?aioe?y “?ai?iaeoeoeaia
caei?ia’y n?i’?, i?iaeaie oa oeyo ?o ae??oaiiy” i.Ee?a, aa?acaiue, 1997
p.;

— I?aeia?iaeia iaoeiaa eiioa?aioe?y “No?aoaa?y ? oaeoeea ai?ioueae c
?ioaeoe?eieie caoai?thaaiiyie” i. Oa?e?a, aeiaoaiue, 1998 p.;

— ui??/i? iaoeia? eiioa?aioe?? (1996-1998) Aoeiaeinueei? aea?aeaaii?
iaaee/ii? aeaaeai??.

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 10 ?ia?o, o oiio /ene?
o oaoiaeo aeo?iaeao — 4, a iaoa??aeao oa oacao — 6 ?ia?o.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioa aeeeaaeaia ia 183 noi??ieao.
Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, oa?aeoa?enoeee
iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy, 3 ?icae?e?a aeanieo
aeine?aeaeaiue, ?icae?eo aiae?co ? ocaaaeueiaiiy iaea?aeaieo
?acoeueoao?a, aeniiae?a, nieneo aeei?enoaieo aeaea?ae (a?o/eciyieo ?
ca?oa?aeieo aaoi??a). ?iaioa ?ethno?iaaia 30 oaaeeoeyie oa 24 ?enoieaie.

Ci?no ?iaioe

Iaoa??ae oa iaoiaee aeine?aeaeaiiy

I?ioyaii 1994-1998 ?ie?a aoei i?iaaaeaii aea/aiiy aeaeiaiai oa
e?euee?niiai neeaaeo i?e?ii?aai?ci?a — caoaeiee?a caiaeueiiai i?ioeano a
1102 ae?iie, oai?eo ia O?N, a?eii a?ae 19 aei 35 ?ie?a.

Aeey aeae?eaiiy aa?iaieo i?e?ii?aai?ci?a (noao?eieie?a, no?aioieie?a,
aioa?iaaeoa??e, inaaaeiiiiaae oa C. albicans) noa?eeueieie ieanoianiaeie
i??ieie i?iaoeaie aei ii/aoeo aioeaaeoa??aeueii? oa?ai?? caae?aee ai?no
oea?a?eaeueiiai eaiaeo, ai?uoaaee eiai o i??iee ne?iaaoeiai-oeoe?iaee
IIA. Aaeoa??ieia?/ia aeine?aeaeaiiy i?iaiaeeee ia i?ci?oa 2 aiaeei c
iiiaioo caai?o aeine?aeaeoaaiiai iaoa??aeo.

Aeae?eaiiy oa ?aeaioeo?eaoe?y iae?aaoieo aiaa?iaieo anii?iaaiieo
aaeoa??e cae?enithaaee ca iaoiaeii, ?ic?iaeaiei o Oa?e?anueeiio IAe?
i?e?ia?ieia?? oa ?ioiieia?? ?i ?.?.Ia/ieeiaa. Aaa?iaeuei? o?eoiiiiaaee
aeyaeyee oeyoii aeaioiaeaiiy iace?a-a?aeaeoe?a neeciai? iaieiiee i?oae
aai oeeee iaoee.

Iaoa??ae aeey aeine?aeaeaiiy ia o?aaieacie (U. urealiticum) caae?aee
c?oe?yaoaaiiyi o?ao?aeueiei oiaoaeai ? aiineee o i?ia??eo c ??aeeei
aeeaeeueiei na?aaeiaeuai.

?aeaioeo?eaoe?th i?e?ii?aai?ci?a i?iaiaeeee caaaeueiii?eeiyoeie
iaoiaeaie. A ie?aieo aeiaaeeao aeey ?aeaioeo?eaoe?? aeei?enoiaoaaee
nenoaio API Staph, yeo io?eioaaee c eaai?aoi??? aaiaoeee a??oeaioiino?
aaeoa??e IAe? ai?aeai?ieia?? oa i?e?ia?ieia?? ?i. I.O.Aaiaea? ?AII
(i?ioani? A.I.Aiiaea?aiei).

Aioea?ioeei/ooeea?noue eoeueoo? aecia/aee ca aeenei-aeeooc?eiei iaoiaeii
(Iaaaoei N.I., Oiieia E.I., 1982).

?aeaioeo?eaoe?th no?aioieie?a i?iaiaeeee ca a?ieia?/ieie aeanoeainoyie:
i?iaeoeoe??th aaiie?cei?a, caeaoi?noth aei ?inoo i?e oaiia?aoo?? 10°N oa
45°N, o aeia/? (10% oa 40%), a oaeiae ca oa?iaioaoe??th eaeoice,
iai?oo, naoa?ice, a?aa?iice, ?ioe?ia, a?aei?ia, ae?oea?eia, nae?oeeia.

I?e aeae?eaii? aiiieie?a ea?oaaeeny iaoiaee/ieie aeac?aeaie c
eaai?aoi?ii? ae?aaiinoeee aiii?a? oa o?eoiiii?aco (i?eeiaeaiea 2 e
i?eeaco Ieienoa?noaa cae?aaiio?aiaiey NNN? ? 1570 io 4 aeaeaa?y 1986
aiaea “Ia oeo/oaiee auyaeaiey aieueiuo aiii?aae e o?eoiiiieacii a
aeooa?neeo e aeiaeieiae/aneeo ioaeaeaieyo, aeaineeo eiinoeueoaoeyo e
o?ieiae/aneeo eaaeiaoao iieeeeeiee”).

Aeae?eaiiy oa ?aeaioeo?eaoe?th inaaaeiiiiaae cae?enithaaee ca?aeii
iaeaco I?i?noa?noaa ioi?iie caei?ia’y N?N? ? 535 a?ae 22 ea?oiy 1985
?ieo “Ia oieoeeaoeee iee?iaeieiae/aneeo (aaeoa?eieiae/aneeo) iaoiaeia
enneaaeiaaiey, i?eiaiyaiuo a eeeieei-aeeaaiinoe/aneeo eaai?aoi?eyo
ea/aaii-i?ioeeaeoe/aneeo o/?aaeaeaiee”.

?aeaioeo?eaoe?th /enoeo eoeueoo? aioa?iaaeoa??e i?iaiaeeee ca iaoiaeii
W. Awing. A ie?aieo aeiaaeeao aeei?enoiaoaaee nenoaie “Aioa?ioano 1 ?
2”, NEA, a oaeiae A??-20A. Iaoiaaii? aa??aioe aoa?eo?e aecia/aee ca
caeaoi?noth i?iaeoeoaaoe aaiioieneie oa na?ieia?/iei iaoiaeii (ca
i???ioiaiith oa oeo?iaaiith ?aaeoe?yie aaethoeiaoe??).

Aiaa?iai? anii?iaaii? aaeoa??? ae?iuoaaee o noaoe?iia?iiio aiaa?inoao?
(NI2-incubator O-125) oaaaenueei? o??ie “ASSAB Medicin AB”. ?o
?aeaioeo?eaoe?th cae?enithaaee ca ii?oieia?/ieie, oeieoi??aeueieie,
eoeueoo?aeueieie, a?io?i?/ieie oa a?ieia?/ieie aeanoeainoyie
(Eaeeie/aiei I.O., Ae?theiaa N.A., Enaaaa N.ss., 1985).

O?aaieacie aecia/aee ca aeiiiiiaith niaoe?aeueieo oano-nenoai,
?ic?iaeaieo Oa?e?anueeei IAe? aea?iaoieia?? oa aaia?ieia??.

Aeieia?/iee noai i?e?ia?ioeaiico oea?a?eaeueiiai ai?noo ioe?ithaaee ca
?iaeaenii iino?eiino? (N), iieacieeaie cono??/aiiy (??) oa cia/ouino?
(N.?. Eeeiithe, 1995).

?ioii-eaai?aoi?ia ianoaaeaiiy oai?eo aeeth/aei aecia/aiiy:

1) aaniethoii? e?eueeino? e?ioioeeo?a o X.109/e; 2) a?aeiinii? ?
aaniethoii? e?eueeino? O-, A- ? I-e?ioioeeo?a; 3) aeoeaieo O-e?ioioeeo?a
(Oa); 4) a?aeiinii? e?eueeino? O-noi?ani??a oa O-oaeia??a;5)
?ioii-?aaoeyoi?iiai ?iaeaeno (???); 6) ai?noo ?ioiiaeiaoe?i?a eean?a I,
G, A o ne?iaaooe? e?ia?; 7) oaaioeeoa?ii? aeoeaiino? (OA) iaeo?io?eueieo
a?aioeioeeo?a; 8) oaaioeeoa?iiai ?iaeaeno (O?); 9) ??aiy oee?eoethth/eo
?ioiieo eiiieaen?a (Oe?E); 10) oeo?o eiiieaiaioa; 11) oeo?o i?e?iaei?o
aioeo?e.

Noaoenoe/iee aiae?c io?eiaieo aeaieo i?iaiaeeany ca iaoiaeaie
aa??aoe?eii? noaoenoeee c aecia/aiiyi na?aaei?o aaee/ei (I), na?aaeiuei?
iioeaee (m) oa na?aaeiueieaaae?aoe/iiai a?aeoeeaiiy (d) (Aoia?ei E.I.,
Aaneeueaa I.I., Aia?inia A.A., 1975).

Eiia??i?noue iiaeeeai? iiieeee eiaeiiai iieacieea aecia/aee ca
noaoenoe/iei e?eoa???i No’thaeaioa (Eaaiia TH.E., Iiai?aethe I.I.,
1990).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

C iaoieia?/iiai iaoa??aeo, acyoiai a?ae 1102 ae?iie, oai?eo ia O?N
aeae?eaii oa ?aeaioeo?eiaaii 3913 ooai?a iaoiaaiieo oa
oiiaii-iaoiaaiieo, a oaeiae aooiooiiieo i?e?ii?aai?ci?a.

Aeae?eai? ooaie i?e?ii?aai?ci?a iaeaaeaee aei 25 oaeniiii?/ieo a?oi
aa?iaieo oa aiaa?iaieo aaeoa??e, ae??aeaeaeiiiae?aieo a?ea?a ?iaeo
Candida, iaei?ino?oeo oa o?aaieaci.

Iae/ano?oa a oea?a?eaeueiiio ai?no? a ia??iae caaino?aiiy aeyaeyeeny
noao?eieiee (79,85 % oai?eo), aioa?iaaeoa??? (64,31 %), anii?iaaii?
aiaa?iai? aaeoa??? (66,43 %), o?aaieacia (57,80 %). ??aeoa aeae?eyeenue
aiiieiee (32,12 %), C. albicans (17,42 %), T. vaginalis (14,70 %),
aa?iai? no?aioieiee (13,71 %) oa inaaaeiiiiaaee (1,45 %). O
aeine?aeaeoaaiiio iaoa??ae? ciaoiaeeeenue anioe?aoe?? iaoiaaiieo oa
oiiaii iaoiaaiieo, aa?iaieo oa aiaa?iaieo, a?aiiiceoeaieo ?
a?aiiaaaoeaieo aaeoa??e, a oaeiae ae??aeaeaeiiiae?aieo a?ea?a,
aaa?iaeueieo o?eoiiiiaae ? o?aaieaci. Eeoa o aeaio ae?iie, oai?eo ia
O?N, aeyaeaia iiiieoeueoo?a aioa?iiaoiaaiieo aoa?eo?e 055:E57. O 1100
ianoaaeaieo oai?eo ia O?N, anoaiiaeaii iayai?noue anioe?aoe?e
i?e?ii?aai?ci?a, ye? neeaaeaeeny c 2-5 ??cieo aeae?a aaeoa??e, a?ea?a,
iaei?ino?oeo oa o?aaieaci. O a?eueoino? (82,76%) ae?iie o
oea?a?eaeueiiio ai?no? aai o ai?no? caaeiueiai neeai?iiy i?oae
ia?nenooaaei iaeii/anii 3 (48,0%) aai 4 aeaee (34,76%) iaoiaaiieo oa
oiiaii iaoiaaiieo, aa?iaieo aai aiaa?iaieo i?e?ii?aai?ci?a.

Aaeeea cia/aiiy iiaea iaoe aeaoaeueia e?euee?nia oa?aeoa?enoeea eiaeiiai
aeaeo i?e?ii?aai?ci?a, ui aoiaeyoue aei anioe?aoe??. Oea aea?
iiaeeea?noue aecia/eoe iioaioe?eia cia/aiiy eiaeiiai anioe?aioa, ui aa?a
o/anoue o oi?ioaaii? caiaeueiiai i?ioeano. Oiio ie i?eae?eeee oaaao
aecia/aiith ?iaeaeno iino?eiino?, iieacieea cono??/aiiy oa ?iaeaeno
cia/ouino? eiaeiiai aeaeo i?e?ii?aai?ci?a o ?icaeoeo caiaeueiiai
i?ioeano ?ai?iaeoeoeaieo i?aai?a. E?euee?niee iieaciee ai?noo iaaiiai
aeaeo i?e?ii?aai?ci?a aoa acyoee iaie ca iniiao i?e aecia/aii?
i?ia?aeiiai caoaeieea caiaeueiiai i?ioeano ?ai?iaeoeoeaieo i?aai?a.
Caoaeieeaie caiaeueiiai i?ioeano aaaaeaeeny o? i?e?ii?aai?cie, ai?no
yeeo o iaoa??ae? ia?aaeuoaaa 5,0 lg EOI ia 1 ie. Anioe?aioe, ye?
aeyaeai? a iaio?e eiioeaio?aoe?? ia aaaaeaeeny i?ia?aeieie caoaeieeaie,
aiie o?eueee iiaee i?aeneethaaoe aaaee?noue ia?aa?ao oai?iae.

?aoaeueiee aiae?c aeaeiaiai oa iiioeyoe?eiiai ??aiy i?e?ii?aai?ci?a, ui
ia?nenoothoue o oea?a?eaeueiiio ai?no? ae?iie, oai?eo ia O?N a ia??iae
caaino?aiiy, iieacaa, ui iniiaieie i?e?ii?aai?ciaie, ye? iathoue
i?ia?aeia cia/aiiy a ao?ieia?? caiaeueiiai i?ioeano ? iaoiaaii? oa
oiiaii iaoiaaii? i?e?ii?aai?cie, ui iaeaaeaoue aei ??cieo oaeniiii?/ieo
a?oi (oaaeeoey 1).

Oaaeeoey I

I?ia?aei? caoaeieee caiaeueiiai i?ioeano o ae?iie, oai?eo ia O?N, a
ia??iae caaino?aiiy

Iniiaiei caoaeieeii caiaeueiiai i?ioeano o ae?iie, oai?eo ia O?N, ?
aiiieie. Ae?oaa i?noea iin?aeathoue aioa?iaaeoa???: aoa?eo??, a oiio
/ene? aioa?iiaoiaaii? oa aioa?ioieneaaii? ooaie, eeaan??ee. O?ao? i?noea
caeiathoue noao?eieiee.

Aiaa?iai? anii?iaiii? aaeoa??? (aaeoa?i?aee ? iaioieie) iniiaieie
caoaeieeaie aoee o 144 ae?iie, oai?eo ia O?N, ? iin?aeaee ca
ao?ieia?/iei cia/aiiyi /aoaa?oa i?noea.

Na?aae aioa?iaaeoa??e i?ia?aeia cia/aiiy o oi?ioaaii? caiaeueiiai
i?ioeano ?ai?iaeoeoeaieo i?aai?a iathoue aoa?eo?? (29,95%).

I?ia?aeieie caoaeieeaie na?aae ooai?a aiaa?iaieo anii?iaaiieo aaeoa??e
aoee B. fragilis (8,08%), P. niger (3,36%) ? B. melaninogenicus (1,63%
oai?eo).

Anioe?aioaie ia?a?aoiaaieo aeua i?e?ii?aai?ci?a ? iaoiaaii? oa oiiaii
iaoiaaii? noao?eieiee (S. aureus, S. epidermidis, S.saprophyticum),
no?aioieiee (S. pyogenes, S. faecalis), aioa?iaaeoa??? (E. coli, E.
aerogenes, E. tarda, P. vulgaris, K. pneumoniae), inaaaeiiiiaaee
(P. aeruginosa), aiaa?iai? anii?iaaii? aaeoa??? (B. fragilis,
B. melaninogenicus, B. assacharalytica, B. urealyticus, P. niger,
P. productus, P. anaerobius), C. albicans, T. vaginalis oa U.
urealyticum.

??aaiue aeae?eaiiy ye i?ia?aeieo caoaeiee?a, oae ? ?o anioe?aio?a
caeaaeaa a?ae naciiieo o?iii?eoi?a. Aiiieiee /ano?oa aeyaeyeeny ae?oeo,
aaniith oa ainaie, a noao?eieiee — ainaie ? ceiith.

Aioa?iaaeoa??? /ano?oa aen?aaeeny ae?oeo ? ainaie, cia/ii ??aeoa —
ceiith oa ?aiiueith aaniith (aa?acaiue i?nyoeue). Aeey aiaa?iaieo
anii?iaaiieo aaeoa??e oa?aeoa?iei ? aen?aaiiy ?o aaniith oa ainaie.

C. albicans /ano?oa ? a a?eueoeo e?eueeinoyo aeyaeyeeny aaniith,
o?aaieacie — aaniith oa ainaie. Aaa?iaeuei? o?eoiiiiaaee ciaoiaeeee o
oea?a?eaeueiiio ai?no? i?ioyaii an?o ia??iae?a ?ieo c iaeiaeiaith
/anoioith.

I?iaaaeai? aeine?aeaeaiiy aioea?ioeei/ooeeaino? aiiieiea aei 25 no/anieo
aioea?ioee?a iieacaee, ui i?aia?aoaie aeai?o aeey ao?io?iiii? oa?ai??
o?ii?/ii? aiii?a?, oneeaaeiaii? O?N, ? aaioai?oeei (88,42% /ooeeaeo
ooai?a) ? oeaoacie?i (62,43%). O ceiiaee ia??iae iaeaoaeoeai?oeie
i?aia?aoaie ii a?aeiioaiith aei aiiieiea aoee aaioai?oeei (79,52%) ?
oeaoaoien?i (75,90%). Aaniith aeioe?eueii i?ecia/aoe aaioai?oeei (95,65%
/ooeeaeo ooai?a), oeaoacie?i (76,09%), oeaoaeio?i (63,77%) ? eaiai?oeei
(55,80%). Aaioai?oeei (96,15%), oeaoacie?i (94,23 %), oeaoaeio?i
(65,38%) ? i?aia?aoaie aeai?o e?eoaaiiy o?ii?/ii? aiii?a?, oneeaaeiaii?
O?N, o e?oi?e ia??iae ?ieo. A in?ii?e ia??iae aioei?e?iaieie
i?aia?aoaie, ui i?iyaeythoue aenieo aeoeai?noue a?aeiinii aiiieie?a ?
aaioai?oeei (80,25%), a a ie?aieo aeiaaeeao — oeaoacie?i (51,85%).

Ceiith iaeaeoeai?oei aei noao?eieie?a ? oeaoacie?i (98,05%),
aaioai?oeei (91,80%), a oaeiae oeaoaoien?i (64,06%). O aaniyiee ia??iae
— aaioai?oeei (96,12%), oeaoacie?i (85,76%), ae?oeo — aaioai?oeei,
oeaoacie?i ? oeaoaeioei.

Aeoeaieie a?aeiinii aei noao?eieie?a, ui aeeeeeathoue caiaeueiee i?ioean
?ai?iaeoeoeaieo i?aai?a ? ia?nenoothoue o oea?a?eaeueiiio ai?no? ainaie
? oeaoacie?i (96,88%) ? aaioai?oeei (95,98%). Iaeaea oaea?/?
iinooia?oueny nai?th aeoeai?noth oeaoaeio?i.

Aioa?iiaoiaaii?, aioa?ioieneaaii? oa aeiooiii? ooaie aoa?eo?e a no/anieo
oiiaao iathoue aenieee nooi?iue ?acenoaioiino? aei a?eueoino?
aioea?ioee?a. Iaeaeoeai?oeie ca no/anieo ee?i?/ieo oiia aoa iie?i?enei
(76,37%), aaioai?oeei (55,79%), oo?aa?i (50,30%) ? eaiai?oeei (46,49%).
O ceiiaee ia??iae aoa?eo?? aoee /ooeea? aei iie?i?eneio (79,77%),
aaioai?oeeio (63,58%) ? oo?aa?io (50,29%).

Aioei?e?iaieie i?aia?aoaie aeai?o aeey oa?ai?? aoa?eo?icii? ?ioaeoe??
aaniith aoee iie?i?enei, eaiai?oeei, oo?aa?i. O e?oith ii?o ?ieo —
iie?i?enei, oeaoaeaenei, ainaie — iie?i?enei, aaioai?oeei, oo?aa?i.

Aiaa?iai? anii?iaaii? i?e?ii?aai?cie ca /ooeea?noth aei aioea?ioee?a
a?ae??ciyeenue a?ae aa?iaieo aaeoa??e. ?c aeae?eaieo 276 ooai?a
aaeoa?i?ae?a (B. fragilis, B. melaninogenicus) o?eueee 64,49% — 86,96%
aoee /ooeea? a?aeiinii oei?aioai?eieo, ea?aai?oeee?io, oeaoaeio?io,
e?ieii?oeeio, iie?i?eneio ? oo?aa?io. A?eueoa iieiaeie aeae?eaieo ooai?a
aaeoa?i?ae?a aoee no?eeeie aei aii?oeee?io (73,19%), aaiceeiai?oeee?io
(88,77%), aeieneoeeee?io (54,35%), a?eo?ii?oeeio (75,36%), ienaoeee?io
(88,04%), ?eoaii?oeeio (81,52%), oao?aoeeee?io (59,06%) ? oeaoia?aeo
(55,43%).

Aeae?eaiee 151 ooai aiaa?iaieo anii?iaaiieo eie?a (P. niger) aeyaeany
/ooeeaei aei oeaoacie?io (60,26%), oeaoaoien?io (58,28%), oeaoaeaeneio ?
e?ieii?oeeio (57,62%), oeaoaeio?io (54,97%) ? ea?aai?oeee?io (53,64%) oa
no?eeei aei aaioai?oeeio, eaiai?oeeio, iie?i?eneio, ?enoii?oeeio,
iaoaoeeee?io, ienaoeee?io, ieaaiaeii?oeeio ? no?aioii?oeeio.

Aeae?eai? 192 ooaie C. albicans aoee /ooeeaeie aei aeaeaiaoieneio
(ooia?noaoe/ia eiioeaio?aoe?y a?ae 0,97 aei 15,6 iea/ie, ooia?oeeaeia —
a?ae 1,95 aei 250 iea/ie). Aiinaio, aioeooia?i ? i?ci?ae ?ia?aoaaee
??no oa ?iciiiaeaiiy C. albicans a eiioeaio?aoe?yo a?ae 1,95 aei 125
iea/ie. Ooia?oeeaeia aeoeai?noue oeeo i?aia?ao?a i?iyaeyeany a aeicao
a?ae 3,9 aei 500 iea/ie. Iacia/ia /ooeea?noue ee?i?/ieo ooai?a C.
albicans anoaiiaeaia aei i?noaoeio, aoii?th, o?ii?th ? aeaeai?io.

Ca aeiiiiiaith noaiaea?oieo ?ioiieia?/ieo oano?a ianoaaeaii 129 ae?iie,
oai?eo ia O?N oa 17 caei?iaeo aeiii??a-ae?iie. A?e ae?iie iniiaii? oa
eiio?ieueii? a?oi aoa iaeiaeiaee — a?ae 19 aei 29 ?ie?a.

Iniaeeaee ?ioa?an noaiiaeee aeai? aea/aiiy O-eaioethaa nenoaie
?ioi?oaoo, a oiio /ene? ?ioii?aaoeyoi?ieo ee?oei. O oai?eo oi?io?oueny
aoi?eiia ?ioiia iaaeinoaoi?noue ca ?aooiie cieaeaiiy aaniethoii? oa
a?aeiinii? e?eueeino? O-e?ioioeeo?a, a oaeiae a?aeiinii? e?eueeino?
O-oaeia??a, O-noi?ani??a ? ?ioii?aaoeyoi?iiai ?iaeaena (1,89±0,07 i?ioe
2,09±0,041 a eiio?ie?).

?acii c oei, niinoa??aa?oueny ii?ooaiiy A-eaioethaa nenoaie ?ioi?oaoo. O
ae?iie, oai?eo ia O?N, anoaiiaeaii cia/ia ca?eueoaiiy aaniethoii?
(0,580±0,016.109/e i?ioe 0,331±0,004.109/e a eiio?ie?) oa a?aeiinii?
(25,20±1,13% i?ioe 14,71±0,22% a eiio?ie?) e?eueeino? A-e?ioioeeo?a.
C?inoaiiy aaniethoii? oa a?aeiinii? e?eueeino? A-e?ioioeeo?a —
i?iaeooeaio?a ?ioiiaeiaoe?i?a ia ni?ey? i?aeaeuaiith eiioeaio?aoe?? Ig
M, Ig G, a o?eueee naeaeoeaii ca?eueoo?oueny eiioeaio?aoe?y
ne?iaaoeiaiai ?ioiiaeiaoe?ia A (4,02±0,11 a/e i?ioe 2,12±0,13 a/e o
eiio?ie?). Ana oea cana?ae/o?, ui a i?ioean? caaino?aiiy O?N
ii?ooothoueny ia o?eueee ee?oeii?, a oaeiae ? aoii?aeuei? iaoai?cie
nenoaie ?ioi?oaoo, ye? iaoiiaeai? cieaeaiiyi ?ioiiaeiaoe?inae?aoi?ii?
ooieoe?? A-e?ioioeeo?a. Aeey i?aeoaa?aeaeaiiy oeueiai iaie i?iaaaeaiee
aiae?c ooieoe?iiaeueii? caeaoiino? A-e?ioioeeo?a oeyoii anoaiiaeaiiy
?iaeaenieo iieaciee?a, ui oa?aeoa?ecothoue a?aeiioaiiy eiioeaio?aoe??
?ioiiaeiaoe?i?a ie?aieo eean?a aei aaniethoii? e?eueeino? A-ee?oei o
ia?eoa?e/i?e e?ia?. Oe? iieacieee iai/ii na?ae/aoue i?i cia/ia cieaeaiiy
caeaoiino? A-e?ioioeeo?a aei neioaco Ig M, Ig G oa i?aeaeuaiiy nae?aoe??
Ig A A-ee?oeiaie o oai?eo ia O?N.

Eieii?caoe?y neeciaeo iaieiiie ?ai?iaeoeoeaieo i?aai?a o oai?eo
anioe?aoe?yie iaoiaaiieo oa oiiaii iaoiaaiieo i?e?ii?aai?ci?a ni?ey?, ia
iaoo aeoieo, i?iieeiaiith i?e?iaieo aioeaai?a a e?ia, aea aiie
aca?iiae?thoue ?c niaoeeo?/ieie ?ioiiaeiaoe?iaie ? ooai?ththoue Oe?E o
i?aeaeuaieo eiioeaio?aoe?yo (148,68±1,39 o.i. i?ioe 89,24±0,71 o.i. a
eiio?ie?).

O ae?iie, oai?eo ia O?N, niinoa??aathoueny oaeiae ci?ie ? a nenoai?
I-e?ioioeeo?a. I?e oeueiio anoaiiaeaia cia/ia ca?eueoaiiy a?aeiinii?
(31,90±1,37% i?ioe 19,71±0,24% a eiio?ie?) oa aaniethoii?
(0,734±0,013.109/e i?ioe 0,443±0,003.109/e a eiio?ie?) e?eueeino?
I-e?ioioeeo?a.

Ia?aa?a oa caaino?aiiy O?N, coiiaeaiiai iaoiaaiieie oa oiiaii
iaoiaaiieie i?e?ii?aai?ciaie noi?iaiaeaeo?oueny ooieoe?iiaeueiith
aeanoaa?e?caoe??th iaoai?ci?a ianiaoeeo?/iiai i?ioe?ioaeoe?eiiai
caoenoo. O ia?oo /a?ao oea noino?oueny oaaioeeoa?ii? aeoeaiino?
iie?ii?oiyaea?ieo eaeeioeeo?a (IIssE). OA oaaioeeooth/eo ee?oei
ia?eoa?e/ii? e?ia? o oai?eo ia O?N cieaeaia aei 69,05±3,17% i?ioe
83,24±0,62% a eiio?ie?, iiieaeaia ? caoiiethth/a caeaoi?noue (O?
4,41±0,27 i?ioe 7,00±0,15 a eiio?ie?). Iaeii/anii ?icaeaa?oueny
iaaeinoaoi?noue nenoaie eiiieaiaioa (oeo? 0,058±0,003 ie i?ioe
0,031±0,001 ie a eiio?ie?).

Oaeei /eiii, o ae?iie, oai?eo ia O?N, oi?io?oueny eiia?iiaaia ?ioiia
iaaeinoaoi?noue, yea iia’ycaia c aeao?oeeoii ee?oeiiiai ? aoii?aeueiiai
eaioetha?a nenoaie ?ioi?oaoo, a oaeiae iaaeinoaoi?noth nenoaie
eiiieaiaioa ? oaaioeeoica.

Aioeaaie eiaeiiai aeaeo i?e?ii?aai?cio a?aeiinii i?aai?cio ethaeeie ?
eiai ?ioiii? nenoaie iathoue na?e ??aaiue /oaea??aeiino?, aioeaaiiino?,
?ioiiaaiiino? oiui. Oiio ?ioiia a?aeiia?aeue i?aai?cio ethaeeie ia
eiaeai aeae i?e?ii?aai?cio iiaea a?ae??ciyoenue ie?aieie iieacieeaie, ui
iiaeia aeei?enoaoe ia o?eueee a ae?aaiinoeoe? caiaeueiiai i?ioeano, a
oaeiae aeey ?ic?iaee oa?aiaaoe/ii? oaeoeee c aeei?enoaiiyi ?ioiio?iiieo
i?aia?ao?a.

Oa?aeoa?iith iniaeea?noth ia?aa?ao oa caaino?aiiy O?N aiiieieiai?
ao?ieia?? aoei ae?aaeaia ciaioaiiy a ia?eoa?e/i?e e?ia? aaniethoii?
(1,72±0,023o109/e i?ioe 2,25±0,07o109/e a eiio?ie?) e?eueeino?
e?ioioeeo?a.Oea ciaioaiiy iaoiiaeaia cia/iei cieaeaiiyi aaniethoii?
(0,656±0,017o109/e i?ioe 1,467±0,02o109/e a eiio?ie?) oa a?aeiinii?
(38,14±1,26% i?ioe 65,20±0,48% a eiio?ie?) e?eueeino? O-e?ioioeeo?a, ia
caaaeath/e ia aeinoia??ia ca?eueoaiiy a?aeiinii? oa aaniethoii?
e?eueeino? A- oa I-e?ioioeeo?a. I?e oeueiio iaei i?noea cieaeaiiy
a?aeiinii? e?eueeino? O-oaeia??a ? O-noi?ani??a, a oaeiae ???
(1,87±0,013 i?ioe 2,09±0,041 a eiio?ie?).

Aiae?c ?ioiiiai noaoono o oai?eo ia O?N, coiiaeaiee S. aureus, oaeiae
iieacaa cia/ia cieaeaiiy aaniethoii? (1,68±0,04.109/e i?ioe
2,25±0,07.109/e a eiio?ie?) e?eueeino? e?ioioeeo?a, ca ?aooiie ciaioaiiy
aaniethoii? (0,622±0,018.109/e i?ioe 1,467±0,02.109/e a eiio?ie?)
e?eueeino? O-e?ioioeeo?a, iacaaaeath/e ia ca?eueoaiiy aaniethoii?
(0,700±0,015.109/e i?ioe 0,443±0,003.109/e a eiio?ie?) e?eueeino?
I-e?ioioeeo?a. Oa?aeoa?iei i?e oeueiio ? a?aeiia?aei?noue aaniethoii?
e?eueeino? A-e?ioioeeo?a eiio?ieuei?e a?oi?. Iniaeea?noth noao?eieieiai?
?ioaeoe?? ?ai?iaeoeoeaieo i?aai?a ? e?eoe/ia cieaeaiiy oeo?o
eiiieaiaioo ao?e/? ii??aiyii c eiio?ieai.

Ia?aa?a oa caaino?aiiy O?N, aeeeeeaiiai aioa?iaaeoa??yie, ui
ia?nenoothoue o oea?a?eaeueiiio ai?no? oaeiae noi?iaiaeaeothoueny
cia/ieie ci?iaie nenoaie ?ioi?oaoo. Niinoa??aaeinue ca?eueoaiiy
aaniethoii? (3,02±0,03.109/e i?ioe 2,25±0,07.109/e o eiio?ie?)
e?eueeino? e?ioioeeo?a, coiiaeaia ??ceei c?inoaiiyi aaniethoii?
(0,824±0,024.109/e i?ioe 0,331±0,004.109/e) e?eueeino? A-e?ioioeeo?a, a
oaeiae I-e?ioioeeo?a (0,728±0,021.109/e i?ioe 0,443±0,003.109/e).

I?e aoa?eo?ici?e ?ioaeoe?? aaniethoia e?euee?noue O-e?ioioeeo?a o
ia?eoa?e/i?e e?ia? a?aeiia?aea? oaeiio iieacieeo caei?iaeo ae?iie
(1,470±0,029.109/e ? 1,467±0,02.109/e a?aeiia?aeii), aea a?aeaoaa?oueny
ciaioaiiy a?aeiinii? (31,67±0,98% i?ioe 43,35±0,57%) e?eueeino?
O-oaeia??a oa O-noi?ani??a (12,33±2,24% i?ioe 20,76±0,32%). I?e oeueiio
??? ci?uo?oueny ai?aai, ui iiaea na?ae/eoe i?i iiaeeea?noue oaiaeaioe??
aei ?icaeoeo aea?a?/iiai aai aooi?ioiiiai i?ioeano.

Ae?aaeaia ca?eueoaiiy aaniethoii? oa a?aeiinii? e?eueeino? A-e?ioioeeo?a
i?e oeueiio aeae? iaoieia?? ia ni?ey? i?aeaeuaiith eiioeaio?aoe??
?ioiiaeiaoe?i?a eeano Ig M, a o?eueee cia/ii ca?eueoo?oueny
eiioeaio?aoe?y (4,40±0,03 a/e i?ioe 2,12±0,13 a/e) ne?iaaoeiaiai
?ioiiaeiaoe?io A. ?acii c oei, ?ioiiaeiaoe?inae?aooth/a caeaoi?noue
A-e?ioioeeo?a cia/ii cieaeaia a?aeiinii aei i?iaeoeoe?? ?ioiiaeiaoe?i?a
iniiaieo eean?a (Ig M, Ig G ? Ig A). ?iaeaene a?aeiioaiue eiioeaio?aoe??
?ioiieo aeiaoe?i?a eean?a Ig M, Ig G ? Ig A aei A-ee?oei (aaniethoii?
e?eueeino?) noaiiaeyoue 1,77±0,07, 19,42±0,26 ? 5,34±0,12 a?aeiia?aeii
aei eiio?ieueieo iieaciee?a — 4,02±0,01, 49,03±0,21 ? 6,40±0,03.

Oa?aeoa?iith iniaeea?noth aoa?eo?icii? ?ioaeoe?? ?ai?iaeoeoeaieo i?aai?a
? i?aeaeuaiiy eiioeaio?aoe?? i?e?iaeieo aioeo?e (9,22±0,91 i?ioe
5,27±0,07 a eiio?ie?).

Iaiaaeai?noue e?oa?aoo?ieo aeaieo i?i ?ieue aaeoa?i?ae?a o caiaeueiiio
i?ioean? ?ai?iaeoeoeaieo i?aai?a, a oaeiae i?i aieea anii?iaaiieo
aiaa?iaieo aaeoa??e ia oaeoi?e ? iaoai?cie ianiaoeeo?/iiai oa
niaoeeo?/iiai ?ioiiiai i?ioe?ioaeoe?eiiai caoenoo i?aai?cio ethaeeie,
aaeueio? aoaeoeaio ?ic?iaeo ao?io?iiii? oa iaoiaaiaoe/ii? oa?ai??
aioei?e?iaieie oa ?ioiio?iiieie i?aia?aoaie.

Aea/aiiy iieaciee?a nenoaie ?ioi?oaoo o 27 ae?iie, oai?eo ia O?N,
iaoiiaeaiee aaeoa?i?aeaie iieacaei, ui niinoa??aa?oueny ca?eueoaiiy
aaniethoii? e?eueeino? e?ioioeeo?a o ia?eoa?e/i?e e?ia? ca ?aooiie
c?inoaiiy oaeiai iieacieea ye o A- oae ? I-ee?oei. A?aeiinia
(47,77±1,49% i?ioe 65,20±0,48%) e?euee?noue O-e?ioioeeo?a cia/ii
(P<0,001) ciaioaia, a a?aeiinia e?euee?noue A-e?ioioeeo?a (28,29±0,72% i?ioe 14,71±0,22%) oa I-e?ioioeeo?a (24,00±0,47% i?ioe 19,71±0,24%) ca?eueoaia. A?aeiinia e?euee?noue O-aeoeaieo e?ioioeeo?a o ia?eoa?e/i?e e?ia? o oai?eo ia O?N, coiiaeaiee aaeoa?i?aeaie, a?aeiia?aea? oaeiio iieacieeo o i?aeoe/ii caei?iaeo ae?iie (P>0,05), aea aaniethoia
e?euee?noue O-aeoeaieo e?ioioeeo?a o oai?eo ciaioaia (P<0,05). C?inoaiiy aaniethoii? oa a?aeiinii? e?eueeino? A-e?ioioeeo?a o oai?eo ia O?N, iaoiiaeaiee aaeoa?i?aeaie, ia ni?ey? i?aeaeuaiith eiioeaio?aoe?? ?ioiiaeiaoe?i?a iniiaieo eean?a. Oae, eiioeaio?aoe?y ne?iaaoeiaiai Ig M ciaioo?oueny, Ig G - a?aeiia?aea? eiio?ieueiiio iieacieeo. Eeoa eiioeaio?aoe?y ne?iaaoeiaiai Ig A - ca?eueoaia (P<0,001), aea caeaoi?noue A-e?ioioeeo?a aei nae?aoe?? ?ioiiaeiaoe?i?a iniiaieo eean?a cia/ii cieaeaia. Ia oii? ci?i niaoeeo?/iiai ?ioiiiai i?ioe?ioaeoe?eiiai caoenoo o oai?eo ia O?N, iaoiiaeaiiai aaeoa?i?aeaie, a?aeaoaa?oueny cieaeaiiy OA (70,86±0,78% i?ioe 83,24±0,62%), O? (4,45±0,07 i?ioe 7,00±0,15), a oaeiae oeo?o eiiieaiaioa (0,04±0,002 ie i?ioe 0,031±0,001 ie). Oaeei /eiii, o oai?eo ia O?N aaeoa?i?aeii? ao?ieia??, oaeiae oi?io?oueny aoi?eiiee ?ioiiaeao?oeeoiee noai c ii?ooaiiyi ia o?eueee ee?oeiieo, aea ? aoii?aeueieo iaoai?ci?a ?ioiii? a?aeiia?ae?. Iaea?aeai? ?acoeueoaoe aea/aiiy iieaciee?a nenoaie ?ioi?oaoo o ae?iie, oai?eo ia O?N, iaoiiaeaiee ??cieie caoaeieeaie, iieacothoue, ui ci?ie aeayeeo iieaciee?a nenoaie ?ioi?oaoo ? caaaeueieie, aiie ia caeaaeaoue a?ae aeaeo i?e?iaa-caoaeieea.Iaeiae, aeaye? c ieo (aaniethoia e?euee?noue e?ioioeeo?a, O-e?ioioeeo?a ? ?o noaiiioeyoe??, nae?aoi?ii? caeaoiino? A-e?ioioeeo?a, nenoaie eiiieaiaioa) caeaaeaoue a?ae i?ia?aeiiai caoaeieea caiaeueiiai i?ioeano. AENIIAEE ?. I?e O?N c ai?noo oea?a?eaeueiiai eaiaeo aeae?eythoueny anioe?aoe?? iaoiaaiieo oa oiiaii iaoiaaiieo aa?iaieo oa aiaa?iaieeo aaeoa??e, o?aaieaci, ae??aeaeiiiae?aieo a?ea?a ?iaeo Candida, aaa?iaeueieo o?eoiiiiaae. Ia?aaaaeathoue /ioe?ueioeiiiiiaioi? (48,0%) oa o?ueioeiiiiiaioi? (34,75%) anioe?aoe??. 2. I?ia?aeieie caoaeieeaie caiaeueiiai i?ioeano ? aiiieiee (32,12%), aoa?eo?? (29,95%), cieioenoee noao?eieie (22,96%), aaeoa?i?aee (9,71%), iaioieie (3,36%), i?iaaiiee no?aioieie (0,27%) i K. pneumoniae (0,09%). 3. *anoioa aeae?eaiiy i?ia?aeieo caoaeiee?a ?c oea?a?eaeueiiai ai?noo i?aeii?yaeeiaaia naciiiei o?iii?eoiai. Aaniith ? ainaie ia?aaaaeii aeae?eythoueny aoa?eo??, aaeoa?i?aee, iaioieie ? iaioino?aioieiee, e?oii - aiiieiee, noao?eieiee. 4. Aeae?eai? ooaie aa?iaieo ? aiaa?iaieo, a?aiiiceoeaieo ? a?aiiaaaoeaieo aaeoa??e iathoue aenieee nooi?iue iie??acenoaioiino? aei a?eueoino? aioea?ioee?a. A?eueo?noue ooai?a aiiieiea /ooeeaa o?eueee ii a?aeiioaiith aei aaioai?oeeio (88,42%) ? oeaoacie?io (62,43%); noao?eieiea - aei aaioai?oeeio (94,77%) ? oeaoacie?io (92,95%); aoa?eo?e - aei iie?i?en?io (76,37%); aaeoa?i?ae?a - aei ea?aai?oeee?io (76,45%), oei?aioai?eieo (86,96%), oeaoacie?io (85,87%), oeaoaoien?io (82,25%) ? oeaoaeio?io (75,00%); iaioieiea - aei oeaoacie?io (60,23%) ? oeaoaoien?io (58,29%). Aeoeai?noue aioeaaeoa??aeueieo i?aia?ao?a aei eiaeiiai aeaeo i?e?ii?aai?cio caeaaeeoue a?ae naciiieo o?iii?eoi?a. 5. O ae?iie, oai?eo ia O?N, oi?io?oueny aoi?eiia ?ioiia iaaeinoaoi?noue, iaoiiaeaia cieaeaiiyi o ia?eoa?e/i?e e?ia? a?aeiinii? oa aaniethoii? e?eueeino? O-e?ioioeeo?a oa ?ioii?aaoeyoi?ieo ee?oei, ???, a oaeiae nae?aoi?ii? ooieoe?? A-e?ioioeeo?a uiaei i?iaeoeoe?? Ig M i Ig G. Niinoa??aa?oueny cieaeaiiy ooieoe?iiaeueii? aeoeaiino? nenoaie ianiaoeeo?/ii? ?acenoaioiino? oai?eo. 6. Noai nenoaie ?ioi?oaoo o oai?eo ia O?N, aei aeayei? i??e caeaaeeoue a?ae aeaeo i?ia?aeiiai caoaeieea. O oai?eo ia O?N, aiiieieiai? oa noao?eieieiai? ao?ieia??, aoi?eiia ?ioiia iaaeinoaoi?noue iaoiiaeaia cieaeaiiyi a ia?eoa?e/i?e e?ia? aaniethoii? e?eueeino? e?ioioeeo?a, aaniethoii? oa a?aeiinii? e?eueeino? O-e?ioioeeo?a ? O-aeoeaieo e?ioioeeo?a, aoaeoi?iiai ?iaeaeno O-e?ioioeeo?a, ?ioii?aaoeyoi?ieo O-e?ioioeeo?a, nae?aoi?ii? ooieoe?? Ig M i Ig G, oaaioeeoa?ii? aeoeaiino? oaaioeeooth/eo ee?oei ? oeo?o nenoaie eiiieaiaioa. 7. O iaoe??io?a c O?N, iaoiiaeaiei ia?nenoaioe??th aoa??o?e oa aaeoa?i?ae?a, oaeiae oi?io?oueny aoi?eiia ?ioiia iaaeinoaoi?noue, a?aei?iia a?ae iiia?aaeiuei? a?oie. O ia?eoa??ei?e e?ia? oi?io?oueny e?ioioeeoic ca ?aooiie ca?eueoaiiy aaniethoii? oa a?aeiinii? e?eueeino? A- ? 0- e?ioioeeo?a, i?aeaeuaiiy eiioeaio?aoe?? Ig A. I?e oeueiio aaniethoia oa a?aeiinia e?euee?noue O-e?ioioeeo?a ia ci?ith?oueny, niinoa??aa?oueny cieaeaiiy nae?aoi?ii? aeoeaiino? A-e?ioioeeo?a a?aeiinii aei ?ioiiaeiaoe?i?a iniiaieo eean?a, oaaioeeoa?ii? aeoeaiino? oaaioeeooth/eo ee?oei, aeoeaiino? nenoaie eiiieaiaioo oa ii?ooaiiy ?ioii?aaoeyoi?ii? ooieoe?? O-e?ioioeeo?a. I?AEOE*I? ?AEIIAIAeAOe?? 1. I?ia?aeieie caoaeieeaie o?ii?/iiai ?aoeeaeeaoth/ai naeuei?iaiioi?eoo o *a?i?aaoeueeiio ?aa?ii? ? aiiieiee (32,12%), aioa?iiaoiaaii?, aioa?ioieneaaii? ? aeiooiii? aoa?eo?? (29,95%), cieioeno? noao?eieiee (22,96%), aaeoa?i?aee (9,71%), iaioieie (3,36%), C. albicans (1,54%), i?iaaii? no?aioiee (0,27%), ye? ciaoiaeyoueny a anioe?aoe?yo c ?ioeie oiiaii iaoiaaiieie aaeoa??yie, o?aaieaciaie, a?eaaie ? o?eoiiiiaaeaie. *anoioa aen?aaiiy caoaeiee?a i?aeii?yaeeiaaia naciiiei o?iii?eoiai. 2. Aeey ao?io?iiiiai e?eoaaiiy ?aeiiaiaeiaaii aeei?enoiaoaaoe i?aia?ao ?c a?oie oeaoaeinii?ei?a - oeaoacie?i, oeaoaoien?i, oeaoaeio?i aei yeeo /ooeea? a?eueo?noue caoaeiee?a. 3. C iaoith i?aeaeuaiiy aoaeoeaiino? ao?io?iiii? oa iaoiaaiaoe/ii? oa?ai?? O?N ?aeiiaiaeo?oueny i?ecia/aiiy ca iiia?aaei?i oanooaaiiyi oa i?iaiicoaaiiyi aoaeoo ?ioiio?iiieo i?aia?ao?a oeaio?aeueii? ?aaoeyoe?? nenoaie ?ioi?oaoo (oeiicei?a, oeiiio?io, O-aeoea?io, o?iie?io, nieai?io oa ?i.), a oaeiae i?aia?ao?a aeey ei?aeoe?? eiia?iiaaii? iaaeinoaoiino? (?ioa?eaee?ie, ?ioa?oa?iie oa ?i.), iaaeinoaoiino? oaaioeeoico (a?oai?ie, ceiicai, i?iae?a?cai oa ?i.), oa nenoaie eiiieaiaioa (ia?aeeaaiiy na?aei? iaoeaii? ieacie e?ia?, i??iaaiae oa ?i.). Nienie ?ia?o, ui iioae?eiaai? ca oaiith aeena?oaoe?? 1. N?aeae E.A. *ooeea?noue aei aioeaaeoa??aeueieo i?aia?ao?a caoaeiee?a caiaeueiiai i?ioeano o ae?iie, oai?eo ia o?ii?/iee ?aoeeaeeaoth/ee naeuei?iaiioi?eo //Aoeiaeinueeee iaaee/iee a?niee. - 1998. - Oii 2, ? 3-4. - N.142-145. 2. N?aeae E.A., Neaei?/oe ?.E. Candida albicans - iii?ooi?noe/ia ?ioaeoe?y i?e o?ii?/ieo caoai?thaaiiyo ?ai?iaeoeoeaieo i?aai?a o ae?iie// ?ioaeoe?ei? oai?iae. - 1997. - ? 4. - N.45-46. 3. Neaei?/oe ?.E., N?aeae E.A. ?ioiiee noaoon i?aai?cio ae?iie, oai?eo ia o?ii?/iee ?aoeeaeeaoth/ee naeuei?iaiioi?eo, iaoiiaeaiee aiiieieii //Aoeiaeinueeee iaaee/iee a?niee. - 1998. - Oii 2, ? 34. - N.53-56. 4. N?aeae E.A., Neaei?/oe ?.E. Cia/aiiy anii?iaaiii? aiaa?iaii? i?e?ioei?e a caaino?aii? o?ii?/iiai naeuei?iaiioi?eoo oa ?? naciii? o?iii?eoie //Oeno. - 1997. - ?1. - N.185-189. 5. Oeiiuoe E.A. I?e?ioei?a aeae?eaiue oeeee iaoee i?e caiaeueieo i?ioeanao y?/ieea o ae?iie ae?oi?iaeiiai a?eo ? ?? /ooeea?noue aei aoii?th //Iaoa??aee neiiic?oio "Neioac, aenia?eiaioaeueia aea/aiiy oa ee?i?/ia canoinoaaiiy /aoaa?oeiieo aiii??aeo niieoe. - *a?i?aoe?, 1995. - N.75. 6. Oeiiuoe E.A. ?ieue noao?eieie?a a ao?ieia?? caiaeueieo i?ioean?a y?/iee?a //Iaoa??aee Oe?a?inueei-Oaaaenueeiai neiiic?oio "Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith. - *a?i?aoe?, 1996. - N.72-74. 7. Oeiiuoe E.A., Ieoanueei O.O. Cia/aiiy iaeeino?eae?aeueii? aia??iaii? i?e?ioei?e a ao?ieia?/i?e no?oeoo?? o?ii?/iiai ?aoeeaeeaoth/iai caiaeaiiy y?/iee?a //Iaoa??aee Oe?a?inueei-Oaaaenueeiai neiiic?oio "Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith. - *a?i?aoe?, 1996. - N.74-75. 8. Oeiiuoe E.A., Neaei?/oe ?.?., Neaei?/oe E.I., Neaei?/oe ?.E. Ao?ieia?y o?ii?/ieo caiaeaiue y?/iee?a o ae?iie ?ai?iaeoeoeaiiai a?eo //Iaoa??aee Oe?a?inueei-Oaaaenueeiai neiiic?oio "Aeooaeuei? ieoaiiy iaaee/ii? aeiiiiiae ianaeaiith. - *a?i?aoe?, 1996. - N.180-181. 9. N?aeae E.A., Neaei?/oe ?.E. O?ii?/iee ?aoeeaeeaoth/ee naeuei?iaiioi?eo - aieiaia i?e/eia iaie?aeiino? o oetha? //Iaoa??aee ia?oi? iaoeiai-i?aeoe/ii? i?aeia?iaeii? eiioa?aioe?? ia oaio "?ai?iaeoeoaaia caei?ia'y n?i'?, i?iaeaie oa oeyoe ?o ae??oaiiy". - Ee?a, 1997. - N.19. 10. N?aeae E.A., Neaei?/oe ?.E. Iieacieee ?ioi?oaoo o oai?eo ia o?ii?/iee naeuei?ia?o ? iioi?eo, iaoiiaeaiee aiiieieii //Iaoa??aee ?anioae?eainueei? iaoeiai-i?aeoe/ii? eiioa?aioe??, i?enay/aii? 50-??//th Oiaeueieoeueei? iaeanii? ee?i?/ii? e?ea?i?. - Oiaeueieoeueeee, 1998. - N.175-176. AIIOAOe?ss N?aeae E.A. I?e?ia?ieia?/i? oa ?ioiieia?/i? aniaeoe o?ii?/iiai ?aoeeaeeaoth/iai naeuei?iaiioi?eoo. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 03.00.07 - i?e?ia?ieia?y. - Oa?e?anueeee iaoeiai-aeine?aeiee ?inoeooo i?e?ia?ieia?? oa ?ioiieia?? ?i. ?.?. Ia/ieeiaa IIC Oe?a?ie. Oa?e?a, 1999. Aea/aiee aeaeiaee oa e?euee?niee neeaae aa?iaieo ? aiaa?iaieo aooiooiiieo ? aeiooiiieo i?e?ii?aai?ci?a ai?noo oea?a?eaeueiiai eaiaeo o 1102 ae?iie, oai?eo ia o?ii?/iee ?aoeeaeeaoth/ee naeuei?iaiioi?eo a ia??iae caaino?aiiy. I?ia?aeieie caoaeieeaie caiaeueiiai i?ioeano ? aiiieie (32,12%), aioa?iiaoiaaii? aoa?eo?? (29,95%), cieioenoee noao?eieie (22,98%), aaeoa?i?aee (9,71%), iaioieie (3,36%), C. Albicans (1,54%) oa ?io? i?e?iiaai?cie (0,36%). Aeae?eaiiy caoaeiee?a ? ?o /ooeea?noue aei aioea?ioee?a i?aeii?yaeeiaai? naciiiei o?iii?eoiai. O iaoe??io?a oi?io?oueny aoi?eiia ?ioiia iaaeinoaoi?noue ca ?aooiie cieaeaiiy aaniethoii? oa a?aeiinii? e?eueeino? O-e?ioioeeo?a, a oiio /ene? ?ioii?aaoeyoi?ieo O-e?ioioeeo?a, ???, nae?aoi?ii? ooieoe?? A-e?ioioeeo?a uiaei i?iaeoeoe?? Ig M ? Ig G, oaaioeeoa?ii? aeoeaiino? ? oeo?o eiiieaiaioa. Nooi?iue ci?i iieaciee?a nenoaie ?ioi?oaoo caeaaeeoue a?ae i?e?iaee i?ia?aeiiai caoaeieea, ui ia?nenoo? a oea?a?eaeueiiio ai?no?. Eeth/ia? neiaa: o?ii?/iee naeuei?iaiioi?eo, i?e?ioei?a, aioea?ioeei/ooeea?noue, ?ioiiiaoiaaiac. AIIIOAOeEss Neaeae E.A. Iee?iaeieiae/aneea e eiioiieiae/aneea aniaeou o?iie/aneiai ?aoeeaeeae?othuaai naeueieiaiioi?eoa. ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 03.00.07 - iee?iaeieiaey. Oa?ueeianueeee iao/ii-enneaaeiaaoaeueneee einoeooo iee?iaeieiaee e eiioiieiaee ei. E.E. Ia/ieeiaa, IIC Oe?aeiu. Oa?ueeia, 1999. I?iaaaeaii eiiieaeniia iee?iaeieiae/aneia ianeaaeiaaiea 1102 aeaiuei a aic?anoa io 19 aei 35 eao, aieueiuo o?iie/aneei ?aoeeaeeae?othuei naeueieiaiioi?eoii a ia?eiae iaino?aiey. Eco/aiea iee?ioei?u niaea?aeeiiai oea?aeeaeueiiai eaiaea i?iaiaeeee iooai iinaaa ia na?eth ieoaoaeueiuo n?aae aeey eoeueoeae?iaaiey aa?iaiuo e aiaa?iaiuo iee?ii?aaieciia. Auaeaeaiiua eoeueoo?u eaeaioeoeoee?iaaiu ii ii?oieiae/aneei, oeieoi?eaeueiui, eoeueoo?aeueiui, aeioeie/aneei e aioeaaiiui naienoaai. *oanoaeoaeueiinoue auaeaeaiiuo eoeueoo? e aioeaaeoa?eaeueiui i?aia?aoai ii?aaeaeyee aeenei-aeeoooceiiiui iaoiaeii. N iaoieiae/aneiai iaoa?eaea auaeaeaii e eaeaioeoeoee?iaaii 3913 ooaiia iaoiaaiiuo, oneiaii iaoiaaiiuo, a oaeaea aooiooiiiuo iee?ii?aaieciia. Auaeaeaiiua iee?ii?aaieciu i?eiaaeeaaeaee e 25 oaeniiiie/aneei a?oiiai aa?iaiuo e aiaa?iaiuo aaeoa?ee, ae?iaeaeaiiaeiaiuo a?eaia ?iaea Candida, i?inoaeoei e o?aaieaciai. Iaeaieaa /anoi a oea?aeeaeueiii niaea?aeeiii a ia?eiae iaino?aiey aunaaaeenue noaoeeieieee, aioa?iaaeoa?ee, anii?iaaiiua aiaa?iaiua aaeoa?ee, o?aaieacia. A enneaaeoaiii iaoa?eaea iaoiaeeeenue annioeeaoeee iaoiaaiiuo e oneiaii iaoiaaiiuo iee?ii?aaieciia, ninoiyuea ec 2-5 aeaeia aaeoa?ee, a?eaia, i?inoaeoeo e o?aaieaci. I?aiaeaaeaee /aou?ao eiiiiiaioiua e o?aoeiiiiiaioiua annioeeaoeee. Ii iiioeyoeeiiiiio o?iaith eaaeaeiai aeaea iee?ii?aaiecia ii?aaeaeyee aaaeouaai aicaoaeeoaey. Ei yaeyeny aiiieiee (32,12%), aoa?eoee (29,95%), cieioenoue noaoeeieiee (22,96%), aaeoa?ieaeu (9,71%), iaioieiee (3,36%), ieiaaiiue no?aioieiee (0,27%). *anoioa auaeaeaiey aaaeoueo aicaoaeeoaeae caaenaea io naciiiuo o?iii?eoiia. Inaiueth e aaniie i?aeiouanoaaiii auaeaeyeenue aoa?eoee, aaeoa?ieaeu, iaioieiee e iaioino?aioieieee. Eaoii - aiiieieee e noaoeeieieee. *oanoaeoaeueiinoue auaeaeaiiuo aicaoaeeoaeae e aioeaaeoa?eaeueiui e oeieioa?aiaaoe/aneei i?aia?aoai caaenaea io naciiiuo o?iii?eoiia. O iaoeeaioia oi?ie?oaony aoi?e/iay eiioiiay iaaeinoaoi/iinoue ca n/ao nieaeaiey aaniethoiiai e ioiineoaeueiiai eiee/anoaa O-eeioioeeoia, a oii /enea eiioii?aaoeyoi?iuo O-eeioioeeoia, E?E, nae?aoi?iie ooieoeee A-eeioioeeoia e i?iaeoeoeee Ig M e Ig G, oaaioeeoa?iie aeoeaiinoe, oeo?a eiiieaiaioa. Noaiaiue eciaiaiee iieacaoaeae nenoaiu eiioieoaoa caaeneo io aaaeouaai aicaoaeeoaey, ia?nenoe?othuaai a oea?aeeaeueiii eaiaea. O aieueiuo O?N aiiieieeiaie e noaoeeieieeiaie yoeieiaee aoi?e/iay eiioiiay iaaeinoaoi/iinoue iaoneiaeaia nieaeaieai a ia?eoa?e/aneie e?iae aaniethoiiai eiee/anoaa eeioioeeoia, aaniethoiiai e ioiineoaeueiiai eiee/anoaa O- eeioioeeoia e O- aeoeaiuo eeioioeeoia, yooaeoi?iiai eiaeaena O- eeioioeeoia, eiioiii?aaoeyoi?iuo O- eeioioeeoia, nae?aoi?iie ooieoeee Ig M e Ig G, oaaioeeoa?iie aeoeaiinoe e oeo?a nenoaiu eiiieaiaioa. O aieueiuo O?N, iaoneiaeaiiui ia?nenoaioeeae aoa?eoee e aaeoa?ieaeia, oaeaea oi?ie?oaony aoi?e/iay eiioiiay iaaeinoaoi/iinoue. Iaaethaeaeinue oaaee/aiea aaniethoiiai e ioiineoaeueiiai eiee/anoaa A- e 0- eeioioeeoia, iiauoaiea eiioeaio?aoeee Ig A. I?e yoii, aaniethoiia e ioiineoaeueiia eiee/anoai O- eeioioeeoia ia iaiyeinue. E?iia oiai iaaethaeaeinue nieaeaiea nae?aoi?iie aeoeaiinoe A- eeioioeeoia, oaaioeeoa?iie aeoeaiinoe, aeoeaiinoe nenoaiu eiiieaiaioa e ia?ooaiea eiioiii?aaoeyoi?iie ooieoeee O- eeioioeeoia. I?iaaaeaiiay ioeaiea ninoiyiey eiioiiie nenoaiu o aieueiuo O?N, iicaieeo ii?aaeaeeoue caaiuey nenoaiu eiioieoaoa, o?aaothuea eiioiii?aaaeeeoaoeee. Eeth/aaua neiaa: o?iie/aneee naeueieiaiioi?eo, iee?ioei?a, aioeaeioeei/oanoaeoaeueiinoue, eiioiiiaoiaaiac. SUMMARY Sidei L.V. Microbiologic and Immunologic Aspects of Chronic Relapsing Salpingooophoritis. – Manuscript. Dissertation for an academic degree of a Candidate of medical Science in speciality 03.00.07 – Microbiology. Kharkiv Research Institute of Microbiology and Immunology named after I.I. Mechnikov. Ministry of Public Health of Ukraine, Kharkiv, 1999. They have investigated the species – specific and quantitative composition of aerobic and anaerobic, autochthonous and allochthonous microorganisms, of the contents of the cervical channel in 1102 women, afflicted with chronic relapsing salpingo-oophoritis during the period of exacerbaion. The chief pathogens of the inflammatory process are gonococcus (32,12%), enteropathogenic escherichia (29,95%), staphylococcus aureus (22,98%), bacteroids (9,71%), peptococcus (3,36%), C. albicans (1,54%) and ather microorganisms (0,36%). Isolation of pathogens and their sensitivity to antibiotics depend on seasonal chronorhythmus. The patients develop secondary immune insufficiency at the expense of a decrease of the absolute and relative number of T-lymphocytes, including immunoregulatory T- lymphocytes, I.R.I., the secretory function of B- lymphocytes as to the production of Ig M and G, the phagocytic activity and the complement titer. The degree of indices changes of the immune system depends on the nature of the chief pathogen which persists in the cervical contens. Key words: chronic salpingooophoritis, microflora, antibioticosensitivity, immunopathogenesis.

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