16

OE?A?INUeEA AEAAeAI?ss AA?A?IEO IAOE

?INOEOOO CAIEA?IANOAA ? A?IEIA?? OAA?EI

E?AEOOI

Aiaaeai Aaneeueiae/

OAeE
626.2:577.121:591.3:577.17:577.118

IAOAAIE?*IEE ? AIOEIENEAeAIOIEE NOAOON I?AAI?CIO AAEEEI? ?IAAOI? OOAeIAE
A ?AIIUeIIO IINOIAOAEUeIIIO IA??IAe? IIOIAAIACO OA OAEOI?E EIAI
?AAOEssOe??

03.00.04 — a?io?i?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa cieuenueeiainiiaea?nueeeo iaoe

Euea?a — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? caiea?ianoaa ? a?ieia?? oaa?ei OAAI

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani?,
/eai-ei?aniiiaeaio OAAI, Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie
NI?OEINUeEEE A.A.,

Euea?anueeee aea?aeaaiee aa?a?iee oi?aa?neoao, ?aeoi?

Io?oe?ei? iiiiaioe:

aeieoi? a?ieia?/ieo iaoe, i?ioani? NIEIAOA E.?., ?inoeooo caiea?ianoaa
? a?ieia?? oaa?ei, caa?aeoaa/ eaai?aoi??? iai?io ?a/iaei

eaiaeeaeao a?ieia?/ieo iaoe, aeioeaio AAEssN A.E.,
Euea?anueea aea?aeaaia aeaaeai?y aaoa?eia?ii? iaaeeoeeie ?i.
Aaeeoeueeiai N.C., caa?aeoaa/ eaoaae?e a?io?i?? ? a?ioaoiieia??

I?ia?aeia i?aai?caoe?y: Oa?e?anueeee ciiaaoa?eia?iee ?inoeooo,
I?ianoa?noai aa?ii?iieneiaiai eiiieaeno Oe?a?ie, eaoaae?a a?io?i??, i.
Oa?e?a.

Caoeno a?aeaoaeaoueny » 16 » eeiiy 1999 ?. i 14-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.368.01

a ?inoeooo? caiea?ianoaa ? a?ieia?? oaa?ei OAAI (290034, i. Euea?a-34,

aoe. A.Noona,38).

C aeena?oaoe??th iiaeia iciaeiieoenue o iaoeia?e a?ae?ioaoe? ?inoeoooo

caiea?ianoaa ? a?ieia?? oaa?ei OAAI

Aaoi?aoa?ao ?ic?neaiee » 28 » o?aaiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, eaiaeeaeao

a?ieia?/ieo iaoe
A.A. *a?e?i

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie.I?aeaeuaiiy aeeoo?caeaoiino? oa
?ioaineo?eaoe?y ?inoo i?iaeoeoeaieo oaa?ei ia ?aii?o noaae?yo
iinoiaoaeueiiai ?icaeoeo ? aeooaeueiith iaoeiai-i?aeoe/iith i?iaeaiith,
ae??oaiiy yei? iaiiaeeeaa aac aeeaieiai i?ciaiiy a?io?i?/ieo i?ioean?a,
ui aecia/athoue aaeaioaoe?ei? iiaeeeaino? oaa?ei ?aiiueiai a?eo. A
?yae? aeine?aeaeaiue iieacaii, ui caa?aaeaiiy oaa?ei a iaiiaoaeueiee
ia??iae, cia/iith i??ith, caeaaeeoue a?ae oi?ioaaiiy iaoai?ci?a, ye?
caaacia/othoue c iaei??? noi?iie, ?aaoeyoe?th ai?iiiaeueiiai aaeaino ?
i?aeo?eiaiiy noano?aoiiai aiiainoaco a i?aai?ci? iiaiia?iaeaeaieo, a c
?ioi? — a?aeiia?aeiee ??aaiue i?ioean?a ia?aeeniiai ieeniaiiy e?i?ae?a
(IIE) oa ooieoe?iiaeueiiai noaio aioeieneaeaioii? nenoaie ee?oei (Donkin
S. et al., 1997; Egli C. et al., 1998; Hammon H. et al., 1998) A?aeiii,
ui ai?iiiaeuei? oaeoi?e a?ae?a?athoue aaaeeeao ?ieue o iaoai?ciao
iaiiaoaeueii? aaeaioaoe?? oaa?ei o ca’yceo c ?o o/anoth a ?aaoeyoe??
i?ioean?a oa?iiaaiaco, aia?aaoe/iiai iaoaaie?cio, ?aaeoe?e a?ineioaco,
i?ie?oa?aoe?? oa aeeoa?aioe?aoe?? ee?oei (Girard J.R., 1986;
Ni?oeinueeee A.A. ? ni., 1989; Kinsbergen M. et al., 1994 ). Oiio,
iaaeinoaoi?e ?icaeoie ai?iiiaeueieo iaoai?ci?a ?aaoeyoe?? iaoaaie?cio
o iiaiia?iaeaeaieo oaa?ei aai ?o ii?ooaiiy i?ae aieeaii
iaa?aeiia?aeieo oaeoi??a aeeaeaiiy /e oiia ciai?oiueiai na?aaeiaeua
iiaeooue coiiaethaaoe niia?eueiaiiy ?icaeoeo i?aai?cio, ?inoo ?
aeic??aaiiy i?aai?a ? oeaiei oa, a oe?eiio, aooe iaei??th c i?e/ei
iecueei? aeeoo?caeaoiino? iieiaeiyea aaeeei? ?iaaoi? ooaeiae ia ?aii?o
noaae?yo iinoiaoaeueiiai iioiaaiaco (Gutzwiller A. et al. 1996; Kralik
A. et al., 1996)

C ?ioi? noi?iie, aaaeeeaa cia/aiiy o i?ioeanao iinoiaoaeueii?
aaeaioaoe?? ia? i?aeo?eiaiiy a?aeiia?aeiiai ni?aa?aeiioaiiy i?ae
?ioaineai?noth a?eue-ii-?aaeeeaeueieo i?ioean?a oa ooieoe?iiaeueiith
aeoeai?noth aioeieneaeaioii? nenoaie a ee?oeiao. A?aeiii, ui
aeoeaaoe?y eeniaaicaeaaeieo eaiie oeaieiiiai iaoaaie?cio o
iiaiia?iaeaeaieo aaaea aei ?ioaineaiiai ooai?aiiy ?aaeoe?eii-caeaoieo
oi?i eeniaaeo iieaeoe, ui a oiiaao iaaeinoaoiuei? ooieoe?iiaeueii?
aeoeaiino? nenoaie aioeieneaeaioiiai caoenoo iiaea coiiaethaaoe
?ioaineo?eaoe?th i?ioean?a ia?ieneaeaoe?? e?i?ae?a oa ?ioeo
a?iiie?ia??a , ni?e/eiyth/e ?icaeoie a i?aai?ci? ieneaeaoe?eiiai no?ano
(Aa?aaie A.A. 1991; Schmidt H. et al., 1996; Aeoaeieia A.A. e ae?.,
1997). Oiio, c iaoith iiia?aaeaeaiiy ii?ooaiue o ee?oeiiiio
iaoaaie?ci? oa caaacia/aiiy aaeaioaoe?eieo iiaeeeainoae i?aai?cio
iaiao?aeia ?ic?iaea niinia?a i?aeaeuaiiy ooieoe?iiaeueii? aeoeaiino?
aioeieneaeaioii? nenoaie o ee?oeiao oaa?ei a ?aiiueiio ia??iae? i?ney
ia?iaeaeaiiy.

A ?yae? aeine?aeaeaiue iieacaii, ui aeaye? i?e?iaeaiaioe, cie?aia naeai
? oeeie, oa?aeoa?ecothoueny aaeaioiaaieie aeanoeainoyie (Neve J. 1991;
Wendel A. 1992; Kralik A. et al., 1996). Oea coiiaeth?oueny ?o o/anoth,
c iaei??? noi?iie, a iaoai?ciao aioeieneaeaioiiai caoenoo ee?oei ye
eioaeoi?e oa?iaio?a -aioeieneaeaio?a, a c ?ioi? — a ?aaoeyoe??
ai?iiiaeueiiai noaoono i?aai?cio. ?acii c oei, aieea aeacaieo
i?e?iaeaiaio?a ia oi?ioaaiiy ai?iiiaeueii-noano?aoieo iaoai?ci?a oa
ooieoe?iiaeueio aeoeai?noue aioeieneaeaioii? nenoaie a ee?oeiao
aaeeei? ?iaaoi? ooaeiae ia ?aii?o noaae?yo iinoiaoaeueiiai ?icaeoeo ia
aeaiee /an ia c’yniaaiee.

Oiio iaoith ?iaioe aoei aeine?aeeoe ai?iiiaeueiee, noano?aoiee oa
aioeieneaeaioiee noaoon aaeeei? ?iaaoi? ooaeiae a ia??iae? a?ae
ia?iaeaeaiiy aei 20-aeaiiiai a?eo oa c’ynoaaoe aieea oa?i?i?a
niiaeeaaiiy iieiceaa i?e?iaeaiaio?a (Zn, Se) ia aeacai? iieacieee.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiioaaeany ca?aeii ieaio iaoeiai-aeine?aeieo ?ia?o ?inoeoooo
caiea?ianoaa ? a?ieia?? oaa?ei OAAI ia 1995-2000 ?iee ii oai?: ”Aea/eoe
iieaeoey?i? iaoai?cie oi?ioaaiiy nenoaie ?aaoeyoe?? iaoaaie?cio,
aaiiiiaco oa ?ioiii? ooieoe?? o naeiae ? aaeeei? ?iaaoi? ooaeiae ia
?aii?o aoaiao iinoiaoaeueiiai ?icaeoeo” (oeo? UA ?0196EI10486).

Iaoa ?iaioe ? caaea/? aeine?aeaeaiue.Aea/eoe ie?ai? aniaeoe
ai?iiiaeueii? ? noano?aoii? ?aaoeyoe?? iaoaaie?cio, ?ioaineaiino?
i?ioean?a IIE oa ooieoe?i-iaeueiiai noaio aioeieneaeaioii? nenoaie o
oaeyo a ca’yceo c a?eii, oa?i?iaie aeiithaaiiy iieiceaa oa i?e aaaaeaii?
i?e?iaeaiaio?a — naeaio ? oeeieo.

Aeey ae??oaiiy aeacaii? i?iaeaie aoee iinoaaeai? ianooii? caaaeaiiy:

1. aeine?aeeoe ci?ie eiioeaio?aoe?e ?inoe?io, ei?oecieo, o?eeiaeoe?ii?io
oa oe?ieneio a ieaci? e?ia? oaeyo o ca’yceo c a?eii, oa?i?iaie
aeiithaaiiy iieiceaa oa i?e aaaaeaii? naeai?oo iao??th ? noeueoaoo
oeeieo;

2. aeine?aeeoe aeeiai?eo ai?noo aetheice, IAAEE, a?eueieo ai?iieeneio,
a?ae?iia?aeen?a e?i?ae?a oa iaeiiiaiai ae?aeueaeaa?aeo a ieaci? e?ia?
oaeyo o ca’yceo c a?eii, oa?i?iaie aeiithaaiiy iieiceaa oa i?e aaaaeaii?
naeai?oo iao??th ? noeueoaoo oeeieo;

3. aea/eoe noai aioeieneaeaioii? nenoaie oa iniaeeaino? aia?aaoe/iiai
iai?io a a?eo?ioeeoao oaeyo o ca’yceo c a?eii, oa?i?iaie aeiithaaiiy
iieiceaa oa i?e aaaaeaii? naeai?oo iao??th ? noeueoaoo oeeieo ia
iniia? aecia/aiiy aeoeaiino? aeooao?iiia?ieneaeace, aeooao?ii?aaeoeoace,
noia?ieneaeaeeniooace, aaenie?iace, i??oaaoe?iace,
eaeoaoaeaa?ae?iaaiace, aetheici-6-oinoaoaeaa?ae?iaaiace oa
eiioeaio?aoe?? aetheice ? 2,3-AeOA a a?eo?ioeeoao.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Io?eiai? ?acoeueoaoe
?ice?eaathoue a?ieia?/i? iniaeeaino? ?aaoeyoe?? iai?io ?a/iaei a
i?aai?ci? oaeyo ?aiiueiai a?eo. A i?ioean? aeine?aeaeaiue aeyaeaii ci?ie
ai?noo ai?iii?a, noano?ao?a aia?aaoe/iiai iai?io, ia?aeiieo ? aoi?eiieo
i?iaeoeo?a ia?aeeniiai ieeneaiiy e?i?ae?a a ieaci? e?ia? oa aeoeai?noue
aioeieneaeaioieo oa?iaio?a a a?eo?ioeeoao oaeyo o ca’yceo c a?eii,
no?ieaie aeiithaaiiy iieiceaa ? ??aiai caaacia/aiiy oaa?ei oaeeie
i?e?iaeaiaioaie ye oeeie i naeai. Iieacaii, ui aeiaeaoeiaa aaaaeaiiy no-

eueoaoo oeeieo a ?aoe?ii oaeyo a eiiieaen? c naeai?oii iao??th
iiceoeaii aieeaa? ia ?o ai?iiiaeueiee ? noano?aoiee noaoon, ?
noi?iaiaeaeo?oueny i?aeaeuaiiyi ooeoe?iiaeueii? aeoeaiino?
aioeieneaeaioii? nenoaie a a?eo?ioeeoao ia?eoa??eii? e?ia?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ia iniia?
o?c?ieiai-a?io?i?/-ieo aeine?aeaeaiue nenoai ?aaoeyoe?? oa noano?aoiiai
caaacia/aiiy iaoaaie?/ieo i?ioean?a o iiaiia?iaeaeaieo oaeyo c’yniaaii
iia? aniaeoe a?ieia?/ieo iniia ae?iuoaaiiy ? aiae?ae? aaeeei? ?iaaoi?
ooaeiae ia ?aii?o noaae?yo iinoiaoaeueiiai ?icaeoeo.

Io?eiai? ?acoeueoaoe na?ae/aoue i?i aeioe?euei?noue aaaaeaiiy a ?aoe?ii
oaeyo ?aiiueiai a?eo niieoe oeeieo (aei 80 ia Zn/ ea nooi? iane) ia oii?
?i’?eoe?e naeai?oo iao??th (c ?ic?aooieo 0,075 ia naeaio/ ea iane) c
iaoith i?aeaeuaiiy ooieoe?iiaeueii? aeoeaiino? nenoaie aioeieneaeaioiiai
caoenoo ee?oei, ca?eueoaiiy ??aiy noano?aoiiai caaacia/aiiy iaoaaie?/ieo
i?ioean?a oa ei?aeoe?? ii?ooaiue ai?iiiaeueiiai noaoono a i?aai?ci?
oaa?ei.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?aeaioiaeaii
iaa?oiooaaiiy oaie aeena?oaoe??, ?ic?iaeaii iaoiaee/i? i?aeoiaee aei
ae??oaiiy iinoaaeaieo caaaeaiue, aeeiiaii aenia?eiaioaeueio /anoeio
?iaioe, i?iaaaeaii aiae?c iaea?aeaieo ?acoeueoao?a oa iaienaiiy
aeena?oaoe?eii? ?iaioe.

Ai?iaaoe?y ?iaioe. Iniiai? ?acoeueoaoe aeena?oaoe?eii? ?iaioe
aeiiia?aeaeeny ia VII Oe?.a?io?i?/iiio c’?cae? (Ee?a, 1997),
i?aeia?iaei?e eiioa?aioe?? “A?ieia?/i? iniiae aeeaeaiiy n/a oaa?ei“
(Euea?a, 1998), i?aeia?iaeiiio neiiic?oi? “Aeieiae/aneea iaoaieciu
noa?aiey” (Oa?e?a, 1998), XV c’?cae? Oe?. o?c?ieia?/iiai oiaa?enoaa
(Euea?a, 1998), ?? i?aeia?iaei?e eiioa?aioe?? “I?iaeaie ia?ioaeoe?eii?
iaoieia??”, (A?ea Oea?eaa, 1998), i?aeia?iaeiiio neiiic?oi? “Osterreich
-Ukraine/Landwirschaft” (A?aeaiue, 1998 ).

Ioae?eaoe??. Ca iaoa??aeaie aeine?aeaeaiue iiaeaii cayaeo ia aeiao?ae (
? 99020859, a?ae 16.02.1999), iioae?eiaaii 8 ?ia?o, c ieo 4 noaoo?.

No?oeoo?a ? ia’?i ?iaioe. Aeena?oaoe?y i?noeoue 159 noi??iee
iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e,
iienaiiy iaoiae?a, ?acoeueoao?a aeine?aeaeaiue oa ?o iaaiai?aiiy,
caeeth/aiiy, aeniiae?a, nieneo e?oa?aoo?e, ui aeeth/a? 329 aeaea?ae, ?c
ieo 217 — ?iicaii?.

IAOA??AEE ? IAOIAeE AeINE?AeAEAIUe

Ania?eiaioaeueia /anoeia ?iaioe aeeiiaia a 1995-1998 ?ieao ia
oaa?eiieoeuee?e oa?i? aea?aeainio “Ci?y” Ooinueeiai ?aeiio,
Oa?iii?euenueei? iaeano? oa aeine?aeiiai ainiiaea?noaa “Ia?ioeii”
Ionoiieo?anueeiai ?aeiio, Euea?anueei? iaeano?. I?e oeueiio i?iaaaeaii
aea? na??? aeine?ae?a. A ia?o?e na??? aeine?aeaeaiue, i?ae?a?aii o?e
a?oie oaeyo- aiaeia?a (ii 10 aie. o eiaei?e) /a?aiii? iieuenueei?
ii?iaee, a?eii a?ae ia?iaeaeaiiy aei 2-o aei?a aeeooy ( eiio?ieueia, I,
II aeine?aei? a?oie), aeeaith ianith 30-35 ea. Oaeyoai eiio?ieueii?
a?oie iaoa?einueea iieiceai aeiithaaee a?ae?aco i?ney ia?oiai acyooy
e?ia? oa ia 6, 12 ? 24 aiae i?ney ia?iaeaeaiiy (i?ney acyooy i?ia
e?ia?). Oaeyoa I aeine?aeii? a?oie io?eioaaee 0,5 % ?-i NaCl ca aeua
caaaeaiith noaiith aiae?ae?, a ia?oa caiaeiaoaaiiy iieiceaa i?iaaaeaii
ia 24 aiae. aeeooy (i?ney acyooy i?ia e?ia?). Oaeyoa ?? aeine?aeii?
a?oie i?e ia?iaeaeaii? io?eioaaee 0,5 % ?-i NaCl, a ia?oa
aeiithaaiiy iiei-

ceaa i?iaaaeaii ia 6 aiae. A iiaeaeueoiio aiae?aey oaa?ei i?iaiaeeeanue
ca iaaaaeaiith aeua noaiith.

Ae?oao na??th aeine?aeaeaiue i?iaaaeaii c aeei?enoaiiyi oaeyo
2-20-aeaiiiai a?eo ( eiio?ieueia, ???,IV aeine?aei? a?oie) a oiiaao
Euea?anueei? iaeano?. Oaa?eiai ??? aeine?aeii? a?oie /a?ac 48 aiaeei
i?ney ia?iaeaeaiiy aioo??oiueii’ycaai aaiaeeee 1-1,5 ie ?ic/eio naeai?oo
iao??th ( a caeaaeiino? a?ae aeeai? iane c ?ic?aooieo 0,075 ia naeaio/ea
iane); oaa?eiai IV aeine?aeii? a?oie — /a?ac 48 aiaeei i?ney
ia?iaeaeaiiy aioo??oiueii’ycaai aaiaeeee ?ic/ei naeai?oo iao??th c
?ic?aooieo 0,075 ia naeaio/ea iane, a ca ?aooiie aeiaeaaaiiy aei
iieiceaa ? iieiea ZnSO4 ai?no oeeieo a ?aoe?ii? oaa?ei oe??? a?oie
aeiaiaeeee aei 80 ia/ea noo. ?a/. Oaeyoai eiio?ieueieo a?oi cai?noue
aeuaaeacaieo i?aia?ao?a aaiaeeee a?aeiia?aeiee ia’?i 0,9 % ?ic/eio NaNl.

Iaoa??aeii aeey aeine?aeaeaiue aoea aaiicia e?ia, yeo io?eioaaee oeyoii
ioieoe?? y?aiii? aaie oaeyo /a?ac 0,5 aiae i?ney ia?iaeaeaiiy , ia 1; 3;
6; 12; 24; 48 aiae. aeeooy oa o oaeyo 3-, 5- ,10- , 20- aeaiiiai a?eo.

A ieaci? e?ia? aecia/aee ai?no ?inoe?io, ei?oecieo, o?eeiaeoe?ii?io,
oe?ieneio, aetheice, eaeoaoo, i??oaaoo, IAAEE, a?eueieo ai?iieeneio,
a?ae?iia?aeen?a e?i?ae?a, iaeiiiaiai ae?aeueaeaa?aeo. E?cao a?eo?ioeeo?a
aeei?enoiaoaaee aeey aecia/aiiy aeoeaiino? aeooao?iiia?ieneaeace,
aeooao?ii?aaeoeoace, noia?ieneaeaeeniooace, aaenie?iace,
i??oaaoaeaa?ae?iaaiace, eaeoaoaeaa?ae?iaaiace,
aetheici-6-oinoaoaeaa?ae?i-aaiace oa ai?noo 2,3-AeOA.

Eiioeaio?aoe?th ai?iii?a a ieaci? e?ia? aecia/aee ?aae?i?ioiieia?/iei
iaoiaeii c aeei?enoaiiyi iaai??a o??ie “OIIIAIO-IAINE” (Aaea?onue). Aeey
aecia/aiiy ai?noo ?inoe?io a e?ia? aeei?enoiaoaaee ?EI-EIN-IA-125I,
ai?no ei?oecieo aecia/aee ca aeiiiiiaith iaai?o NOA?II-E-125I-I, ai?no
3,3’,5 o?eeiaeoe?ii?i aecia/aee ca aeiiiiiaith iaai?o ?EI-O3-IA, ai?no
oe?ieneio aecia/aee ca aeiiiiiaith iaai?o ?EI-O4-IA. Eiioeaio?aoe?th
ai?iii?a a e?ia? aecia/aee ia e?/eeueieeo aaia-aei?ii?ithaaiiy “COMPI
-GAMA 1282”. ?ic?aooiee i?iaiaeeee a eii?aeeiaoao “logit-log”.

Aeoeai?noue aeooao?iiia?ieneaeace (AI) ( EO 1.11.1.9) aecia/aee
iaoiaeii Ii?ia A.I. ( 1986) a iiaeeo?eaoe?? Aioiiye A.E., Ao/ei I.I. (
1998) ca oaeaee?noth ieeniaiiy aeooao?iio a i?enooiino? a?ae?iia?aeeno
o?aoeiiiai aooeeo. Aeoeai?noue aeooao?ii?aaeoeoace ( EO 1.6.4.3)
aecia/aee ca oaeaee?noth a?aeiiaeaiiy aeooao?iio a i?enooiino? NADPH (
Aeaniaa N. e ae?. 1990; Aioiiye A.E., 1998 ). Aeoeai?noue
noia?ieneaeaeeniooace aecia/aee ca?aeii aei iaoiaeo Aeoa?i?ii? A.A. oa
?i., (1983).

Aeoeai?noue aaenie?iace (EO 2.7.1.1), i??oaaoe?iace (EO 2.7.1.40),
eaeoaoaeaa?ae?iaaiace (EO 1.1.1.27), aetheici-6-oinoaoaeaa?ae?iaaiace
(EO 1.1.1.49) aecia/aee niaeo?ioioiiao?e/ieie iaoiaeaie, ye? aacothoueny
ia aeei?enoaii? ni?yaeaieo nenoai ieeneaiiy ? a?aeiiaeaiiy
i?eioeiai?aeieo eioa?iaio?a ( Chapman R. et al. 1962;
Bergmeyer H.Y. 1974).

Eiioeaio?aoe?th a?eea a aaiie?caoao aecia/aee ca iaoiaeii Eio?? (1951).
Eiioeaio?aoe?th iaeiiiaiai ae?aeueaeaa?aeo a ieaci? e?ia? aecia/aee
iaoiaeii Ei?iaaeieeiai? A.I. (1989), a?ae?iia?aeen?a e?i?ae?a- iaoiaeii
Ie?ii/eea I.I. e ae?., (1984). A ieaci? e?ia? aecia/aee ai?no aetheice
aetheiciieneaeaciei iaoiaeii (Hanson R.W., 1981), i??oaaoo (Bergmeyr
H.Y., 1974), eaeoaoo (Bergmeyer H.Y,1974), iaaoa?eo?eiaai? aee?i?
eeneioe (IAAEE) (I?ioi?iaa I.E. e ae?. 1982). Eiioeaio?aoe?th a?eueieo
ai?iieeneio a ieaci? e?ia? oaeyo aecia/aee ia ai?iieeneioiiio
aiae?caoi?? AAA- 339 I.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss.

Aieea oa?i?i?a niiaeeaaiiy iieiceaa oa aaaaeaiiy naeai?oo iao??th ?
noeueoaoo oeeieo ia eiioeaio?aoe?th ai?iii?a a ieaci? e?ia? oaeyo. A
i?ioean? aeine?aeaeaiue anoaiiaeaii, ui aaaeeeaa ?ieue o oi?ioaaii? a
i?aai?ci? iiaiia?iaeaeaieo oaa?ei a?aeiia?aeieo ?aaoeyoi?ieo iaoai?ci?a
iaeaaeeoue ni?aa?ae-iioaiith ie?aieo ai?iii?a, ye? ? ?aaoeyoi?aie
oa?iiaaiaco ? ae?eai??, a oaeiae i?ioean?a ?inoo ? ?icaeoeo i?aai?cio
oaa?ei a ?aiiueiio iinoiaoaeueiiio ia??iae?.

Oae, ca?aeii aei io?eiaieo aeaieo (Oaae.1; Oaae. 2), iiaiia?iaeaeai?
oaeyoa oa?aeoa?ecothoueny iecueeei ai?noii ?inoe?io a e?ia?. Aeiithaaiiy
iieiceaa oaeyoai eiio?ieueii? a?oie ni?eyei i?aeaeuaiith
ooieoe?iiaeueii? aeoeaiino? i?ae-oeoieiai? caeice, aiane?aeie /iai aaea
/a?ac 1 aiae i?ney ia?oi? aiae?ae? eiioeaio?aoe?y ?inoe?io a ieaci?
e?ia? oaa?ei c?inoaea a?eueo i?ae o 3 ?ace (? < 0,001). Cao?eiea aeiithaaiiy iieiceaa aei 6-?, a iniaeeai aei 24-? aiaeeie i?ney ia?iaeaeaiiy coiiaethaaea o oaa?ei ?? ? ? a?oi ?icaeoie a?ii?inoe?iai?? (? < 0,01; ? < 0,001). A oie naiee /an eiioeaio?aoe?? ei?oecieo oa ?ioeo eaoaaie?/ieo ai?iii?a a ieaci? e?ia? aoee aenieeie. Iaeaeuiai ??aiy eiioeaio?aoe?y ei?oecieo o e?ia? oaeyo aeinyaaea i?ioyaii ia?oeo oaeeei i?ney ia?iaeaeaiiy. Iacaaaeath/e ia oa, ui ooieoe?iiaeueia aeoeai?noue ei?e iaaeie?iee?a o oaeyo an?o aeine?aeieo a?oi i?ioyaii ia?oeo aiaeei aeeooy nooo?ai cieaeo?oueny, o oaa?ei ? ? ?? aeine?aeieo a?oi oea cieaeaiiy ? iaio ae?aciei. Aeyaeai? ci?ie eiioeaio?aoe?? ei?oecieo o oaeyo oeeo a?oi iiaeooue na?ae/eoe i?i i?aeaeuaiiy no?aniai? ?aaeoe?? ei?e iaaeie?iee?a i?ae aieeaii aiae?aaeueieo oaeoi??a. A i?ioean? aeine?aeaeaiue anoaiiaeaii, ui ??ci? oa?i?ie aeiithaaiiy iieiceaa cia/iith i??ith aieeaathoue ia ooieoe?iiaeueio aeoeai?noue ueoiaeaeii? caeice ? aaaeooue aei ci?i eiioeaio?aoe?e oe?ieneio (O4) ? o?eeiaeoe?ii?io (O3) a ieaci? e?ia? oaeyo ?aiiueiai a?eo. Ca?aeii aei io?eiaieo ?acoeueoao?a, i?ioyaii ia?oeo aiaeei i?ney ia?iaeaeaiiy ai?no oe?ieneio a e?ia? oaeyo c?inoa? a 1,9 ?ace. Iaeneiaeuei? eiioeaio?aoe?? oeueiai ai?iiio a ieaci? e?ia? oaa?ei eiio?ieueii? a?oie niinoa??aaeenue ia 3-?e ? 6-?e aiaeeiao i?ney ia?oiai aeiithaaiiy iieiceaa, ui ni?aiaaeaei c iaea?eueoei c?inoaiiyi ai?noo o?eeiaeoe?ii?io. Oaaeeoey 1.- Aieea oa?i?i?a niiaeeaaiiy iieiceaa ia eiioeaio?aoe?th ai?iii?a a ieaci? e?ia? oaeyo (Im; n= 5-6) A?e A?oiaoaa?eieiio?ieue? a?oia?? a?oia?inoe?i (ieiae/ie)0,5 aiae8,75 0,767,35 0,618,9 0,531 aiae29,82,47c4,10,8***3,91,2***3 aiae11,82,05b3,80,6**3,50,8**6 aiae10,7 1,83,20,45**3,40,6**12 aiae16,6 2,42,90,5***11,01,824 aiae8,301,4a3,00,4**7,21,048 aiae6,631,05,81,14,90,6Ei?oecie (iiieue/e)0,5 aiae241,324,0261,338,1248,433,71 aiae139,612,3b185,726,4176,325,43 aiae130,617,76163,119,3153,917,26 aiae123,48,0148,89,1144,59,612 aiae80,55,7b110,46,7*99,85,2*24 aiae 83,06,299,55,8*97,56,248 aiae58,24,9a70,66,264,35,1Oe?ienei (iiieue/e) 0,5 aiae95,911,990,59,689,310,21 aiae187,217,7b174,916,94182,418,33 aiae270,540,5a197,820,6210,726,56 aiae276,214,7202,622,8*200,325,1*12 aiae179,320,2b123,79,1*138,417,924 aiae 153,1720,6131,212,3135,815,648 aiae126,987,8107,49,595,48,1O?eeiaeoe?ii?i (iiieue/e)0,5 aiae7,10,987,20,647,30,591 aiae9,5 0,6b8,70,89,30,753 aiae12,10,85a9,11,09,50,846 aiae12,30,948,51,2*8,721,112 aiae10,31,07,10,82*9,22,0324 aiae 10,81,357,20,6*8.31,1848 aiae8,160,77,40,97,150,4 I?ei?oea: a oe?e ? a ianooiieo oaaeeoeyo a??ia?aei?noue a?aei?iiinoae o cia/aiiyo iieaciee?a i?ae a?eiaeie a?oiaie oaa?ei iicia/aii ye a, b, c- (a -p<0,05; b -p<0,01; c -p<0,001); a??ia?aei?noue a?aei?iiinoae o cia/aiiyo iieaciee?a i?ae eiio?ieueiith ? aeine?aeiith a?oiaie iicia/aii ye *, **-, *** (*-p<0,05; **-p<0,01; ***-p<0,001). I?ioa, aaea ia 12-?e aiaeei? i?ney ia?iaeaeaiiy a?aeaoaa?oueny cia/ia cieaeaiiy eiioeaio?aoe?? oe?ieneio a ieaci?, oiae? ye ??aaiue O3 caeeoa?oueny aenieei i?ioyaii ia?oeo aeaio aei?a aeeooy. I?e a?aeno?i/aii? aeiithaaiiy iieiceaa eiioeaio?aoe?y oe?ieneio ? o?eeiaeoe?ii?io a ieaci? e?ia? oaeyo ? ? I? aeine?aeieo a?oi caeeoaeeny nooo?ai ieae/eie o ii??aiyii? c oaeeie o oaeyo eiio?ieueii? a?oie. Oaaeeoey 2. - Aieea naeai?oo iao??th oa noeueoaoo oeeieo ia eiioeaio?aoe?th ai?iii?a a ieaci? e?ia? oaeyo (Im; n= 5-6) A?e A?oiaoaa?eieiio?ieue ??? a?oia?V a?oia?inoe?i (ieiae/ie) 3-aeaii?6,850,467,470,558,00,75-aeaii?5,65 0,477,33 0,51*8,120,78*10-aeaii?5,960,548,610,92*12,11,05**20-aeaii?16,32,05a20,5 1,323,11,8* Ei?oecie (iiieue/e)3-aeaii?69,75 5,258,35,1 54,83,95-aeaii?88,766,7564,95,8*59,55,25*10-aeaii?37,203,8c34,53,732,52, 920-aeaii?35,7 5,532,34,931,73,4Oe?ienei (iiieue/e)3-aeaii?82,47,81b62,45,4*63,15,1*5-aeaii?67,95,253,13,05*52,43 ,5*10-aeaii?66,92,3059,65,868,53,620-aeaii?68,45,3654,33,265,23,1O?eeiae oe?ii?i (iiieue/e)3-aeaii?4,060,35b6,170,48**5,980,42**5-aeaii?3,80,294,940,34*4 ,790,28*10-aeaii?3,660,323,830,413,90,3720-aeaii?2,760,31a 3,20,343,060,39 ?acoeueoaoe aeine?aeaeaiue aeacothoue ia oa, ui i?ney aaaaeaiiy i?e?iaeaiaio?a a?aeaoaathoueny a??ia?aei? ci?ie ai?noo ie?aieo ai?iii?a o ieaci? oaeyo (Taae. 2). Oae, i?ney aaaaeaiiy naeai?oo iao??th, a ieaci? oaa?ei ci?ithaaeinue ni?aa?aeiioaiiy i?ae ai?noii oe?ieneio ? o?eeiaeoe?ii?io, aiane?aeie a??ia?aeiiai i?aeaeuaiiy eiioeaio?aoe?? O3 oa ciaioaiiy ??aiy O4 a ieaci? 3-5-aeaiieo oaeyo ??? ? ?V aeine?aeieo a?oi ( Oaae.2). I/aaeaeii, oea ca’ycaia c ?ioaineo?eaoe??th i?ioeano O4 O3 eiiaa?n?? a ee?oeiao ueoiaeaeii? caeice oa i?aai?a iicaoe?ai?aeaeueiiai ooai?aiiy o?eeiaeoe?ii?io, iiina?aaeeiaaii? nenoaiith naeaiiai?nieo aeaei- aeeiac (Larsen P., Berry M.,1995). ?acii c oei, i?ney aaaaeaiiy naeai?oo iao??th niinoa??aa?oueny i?aeaeuaiiy ai?noo ?inoe?io a e?ia? oaeyo 5- ? 10-aeaiiiai a?eo oa cieaeaiiy eiioeaio?aoe?? ei?oecieo o 5-aeaiieo oaeyo ( Oaae.2). Aeiaeaaaiiy aei ?aoe?iio oaeyo noeueoaoo oeeieo ia oii? ?i’?eoe?? naeai?oo iao??th ni?eyei cia/iiio c?inoaiith ai?noo ?inoe?io a e?ia?, ui aoei iniaeeai ae?aciei o 10- ? 20-aeaiieo oaa?ei, ? noi?iaiaeaeoaaeiny ciaioaiiyi eiioeaio?aoe?? ei?oecieo a ieaci? ( Oaae. 2). Oaea yaeua iiaea aeacoaaoe ia ciaioaiiy i?ae aieeaii oeeo i?e?iaeaiaio?a aeeaeie, oa?aeoa?iiai aeey i?aai?cio iiaiia?iaeaeaieo oaa?ei, iaoaaie?/iiai no?ano oa ni?eyoe ?ioaineo?eaoe?? aiaaie?/ieo i?ioean?a o ee?oeiao oaa?ei. Aieea oa?i?i?a niiaeeaaiiy iieiceaa oa aaaaeaiiy naeai?oo iao??th ? noeueoaoo oeeieo ia oi?ioaaiiy noano?aoiiai noaoono oaeyo. A i?ioean? iino-iaoaeueii? aaeaioaoe?? a e?ia? ? oeaieiao aaeeei? ?iaaoi? ooaeiae a?aeaoaa?oueny anoaiiaeaiiy a?aeiia?aeieo ni?aa?aeiioaiue i?ae ai?noii noano?ao?a oa ?ioa?iaae?ao?a iai?io ?a/iaei. sse iieacothoue ?acoeueoaoe iaoeo aeine?aeaeaiue, oaeyoa ia?iaeaeothoueny ?c a?aeiinii iecueeei ai?noii iniiaieo aia?aaoe/ieo noano?ao?a- aetheice oa IAAEE a ieaci? e?ia?. A oie naiee /an, a ?o e?ia? aeyaeythoueny aenie? eiioeaio?aoe?? eaeoaoo ? i??oaaoo. I?ioyaii ia?oi? aiaeeie aeeooy eiioeaio?aoe?y IAAEE a ieaci? oaeyo c?inoa? o 2,5 ?ace ( ?<0,001). I?e/eiith oeueiai yaeua, i/aaeaeii, ? ?ioaineo?eaoe?y e?iie?co o aee?ia?e oeaiei? iiaiia?iaeaeaieo, yea coiiaeth?oueny i?aeaeuaiiyi eiioeaio?aoe?? eaoaoieai?i?a a e?ia? (Wintour E., Marelyn F., 1984; Girard J.R., 1986). ?acii c oei, aeuee ai?no IAAEE o eiio?ieuei?e a?oi? oaa?ei ii??aiyii c oaa?eiaie ? oa ?? aeine?aeieo a?oi, iiaea coiiaethaaoeny iaaeoiaeaeaiyi a e?ia i?iaeoeo?a a?ae?ie?co o?eaoeeeae?oea?ie?a iieiceaa oa aeuith caeaoi?noth ?aaoeyoi?ieo nenoai i?aai?cio oaa?ei oe??? a?oie aei iia?e?caoe?? noano?ao?a aia?aaoe/iiai iai?io. ?acii c i?aeaeuaiiyi eiioeaio?aoe?? aetheice i?ioyaii ia?oeo 48 aiae. aeeooy, a ieaci? e?ia? oaeyo eiio?ieueii? a?oie cia/ii cieaeothoueny eiioeaio?aoe?? eaeoaoo ? i??oaaoo. I?ioa, o iaaiaeiaaieo oaeyo i?ioyaii ia?oeo 6-e aiae aeeooy ai?no aetheice a ieaci? e?ia? aoa a??ia?aeii ieae/ei ii??aiyii c oaa?eiaie eiio?ieueii? a?oie (?0,01 ? ?0,001). Iacaaaeath/e ia oa, ui ia 6-?e aiae. aeeooy a?aeaoaaeiny i?aeaeuaiiy ai?noo oeueiai iiiinaoa?eaeo a ieaci? e?ia? oaeyo I i II a?oi ii??aiyii c eiio?ieueieie oaa?eiaie, eiioeaio?aoe?y aetheice caeeoaeany a??ia?aeii ieae/ith(?0,05).Ai?no eaeoaoo a e?ia? oaeyo, yeei ia aeiithaaee iieiceai, ia?aaeuoaaa aiaeia?/i? iieacieee o oaa?ei eiio?ieueii? a?oie, i?ioa a?eia? ci?ie eiioeaio?aoe?? oeueiai iaoaaie?oo a e?ia? oaeyo aoee iaio ae?acieie. Eiioeaio?aoe?y i??oaaoo a ieaci? e?ia? oaa?ei a??ia?aeii cieaeoaaeanue i?ae e?iaoeue ia?oi? aeiae aeeooy (?<0,05). Oaeei /eiii aiae?c iaaaaeaieo aeaieo na?ae/eoue i?i oa, ui ci?ie ai?noo e?ioeaaeo iaoaaie?o?a ae?eie?co ? iane?aeeii neeaaeieo aaeaioaoe?eieo i?ioean?a, ye?, i/aaeaeii, ia?aaoaathoue o aca?iica’yceo c i?ioeanii noaiiaeaiiy aetheiiaiaaiaco a ia/?ioe? iiaiia?iaeaeaieo oaa?ei ? ciaoiaeyoueny i?ae ?aaoeyoi?iei eiio?ieai caeic aioo??oiuei? nae?aoe?? oa oaeoi??a aiae?ae?. Oaaeeoey 3- Aieea oa?i?i?a niiaeeaaiiy iieiceaa ia eiioeaio?aoe?th noano?ao?a aia?aaoe/iiai iai?io o oaeyo. (Im; n= 5-6) A?e A?oiaoaa?eieiio?ieue? a?oia?? a?oiaAetheice (ieiieue/ie)0,5 aiae2,220,242,430,312,580,291 aiae3,680,3b2,150,27**2,250,24**3 aiae3,560,352,010,21**2,110,22**6 aiae4,140,232,980,2*2,870,28*12 aiae4,350,243,240,25*3,580,2824 aiae 4,690,332,950,26**3,640,27*48 aiae4,870,273,70,25*4,00,22*Eaeoao (iiieue/ie)0,5 aiae4,470,174,660,154,710,191 aiae2,240,12c2,580,142,480,133 aiae2,380,232,40,182,550,236 aiae2,470,182,50,202,380,1712 aiae2,050,112,440,12*2,250,1424 aiae 1,90,132,190,13*2,10,1548 aiae1,880,182,070,121,980,15I??oaao (iiieue/ie)0,5 aiae0,1880,0340,2060,040,2110,0311 aiae0,1980,0380,2020,020,2010,0313 aiae0,1680,0260,1910,0280,2070,0216 aiae0,1770,01380,1580,0140,1880,01812 aiae0,1860,0110,1910,0150,1900,01524 aiae 0,1860,0110,1850,0140,1910,01248 aiae0,1470,011a0,1580,010,1600,009IAAEE ( ieaea / e)0,5 aiae290,223,1261,128,1303,430,41 aiae725,468,9c546,251,9594,544,13 aiae710,763,0528,051,4547,352,86 aiae698,554,2540,9 42,5590,145,512 aiae696,156,3535,941,1589,341,524 aiae 652,241,0522,232,3*578,739,148 aiae630,436,2506,927,3*560,029,0 Ii?yae c? anoaiiaeaiiyi a?aeiia?aeieo ni?aa?aeiioaiue i?ae ai?noii noano?ao?a ? iaoaaie?o?a iai?io aoaeaaiae?a oa e?i?ae?a i?ioean iaiiaoaeueii? aaeaioaoe?? o oaeyo iia’ycaiee c? cia/ieie ci?iaie eiioeaio?aoe?e a?eueieo ai?iieeneio a e?ia?. A i?ioean? aeine?aeaeaiue anoaiiaeaii, ui i?ioyaii ia?oeo aiaeei i?ney ia?iaeaeaiiy nooo?ai cieaeo?oueny ??aaiue aetheiaaiieo ai?iieeneio - aeai?io, aeooai?io ?, a iaio?e i???, na?eio a ieaci? e?ia? ye o oaa?ei eiio?ieueii? a?oie, oae ? a oaa?ei, ye? ia io?eioaaee iaoa?einueeiai iieiceaa. Caaaeii, ai?no cai?iieo ai?iieeneio a e?ia? oaeyo eiio?ieueii? ? ? aeine?aeii? a?oi i?ioyaii ia?oi? aeiae aeeooy nooo?ai ia a?ae??ciy?oueny. ?acii c oei, o ia?o? aiaeeie i?ney ia?iaeaeaiiy a?aeaoaa?oueny cia/ia c?inoaiiy eiioeaio?aoe?e ?icaaeoaeaieo ai?iieeneio o oaa?ei eiio?ieueii? a?oie, oiae? ye o aieiaeoth/eo oaeyo oea i?aeaeuaiiy ? iaio ae?aciei. I/aaeaeii, i?e/eiaie cieaeaiiy ai?noo oeeo ai?iieeneio o aieiaeoth/eo oaa?ei ? ?ioaineo?eaoe?y ?o eaoaaie?cio a oeaieiao, ui a?ae?a?a? aaaeeeao ?ieue a caaacia/aii? aia?aaoe/ieo iio?aa i?aai?cio. Ca?aeii c ?acoeueoaoaie aeine?aeaeaiue, aaaaeaiiy ?ii?a naeaio ? oeeieo ye? ? eiiiiiaioaie aaaaoueio ?aaoeyoi?ieo nenoai, cia/iith i??ith aecia/a? nea?iaai?noue a?io?i?/ieo ?aaeoe?e o ee?oeiao oa oa?aeoa? ooee?caoe?? noano?ao?a a aiaaie?/ieo oa eaoaaie?/ieo i?ioeanao ? noi?iaiaeaeo?oueny a?aeiia?aeieie ci?iaie eiioeaio?aoe?? noano?ao?a ? iaoaaie?o?a aia?aaoe/iiai iai?io. C io?eiaieo ?acoeueoao?a aeaeii, ui i?e aaaaeaii? oaeyoai 2-aeaiiiai a?eo naeai?oo iao??th ? noeueoaoo oeeieo eiioeaio?aoe?y aetheice oa i??oaaoo a e?ia? oaa?ei nooo?ai ia a?ae??ciythoueny a?ae oaeeo o oaeyo eiio?ieueii? a?oie. ?acii c oei, a ieaci? e?ia? 10-? 20-aeaiieo oaa?ei aeine?aeieo a?oi cia/ii ciaioo-?oueny eiioeaio?aoe?y eaeoaoo. I?ae aieeaii niieoe naeaio oa oeeieo o oaeyo iaio aeine?aeieo a?oi niinoa??aa?oueny c?inoaiiy ai?noo IAAEE a ieaci? e?ia?, ui ? iniaeeai oa?aeoa?iei aeey 3- ? 5-aeaiieo oaa?ei. Ci?ie ai?noo a?eueieo ai?iieeneio a ieaci? e?ia? oaa?ei i?ney aaaaeaiiy i?e?iaeaiaio?a noinothoueny, a iniiaiiio, ai?iieeneio c ?icaaeoaeaiei aoaeaoeaaei eaioethaii oa aeayeeo iacai?iieo ai?iieeneio. Cie?aia, aeyaeaii a??ia?aeia i?aeaeuaiiy eiioeaio?aoe?e aae?io, eaeoeeio, ?cieaeoeeio oa a?noeaeeio a ieaci? e?ia? 3-5- aeaiieo oaeyo iaio aeine?aeieo a?oi oa cieaeaiiy ai?noo oeeo ai?iieeneio o oaeyo 10- ? 20- aeaiiiai a?eo IV a?oie. ?acii c oei, a ieaci? e?ia? oaeyo 3- ? 5-aeaiiiai a?eo a??ia?aeii cieaeothoueny eiioeaio?aoe?? oe?iceio, iao?ii?io, o?aii?io. Oaeei /eiii, io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui a ia?o? aiaeeie aeeooy a ieaci? e?ia? oaeyo nooo?ai ci?ith?oueny ni?aa?aeiioaiiy i?ae noano?aoaie aia?aaoe/iiai iai?io. I?e oeueiio noai?ththoueny oiiae aeey aeoeaaoe?? iaoaaie?cio aetheice ae?eie?oe/iei oeyoii, aeniei? aeinooiiino? IAAEE aeey ieenethaaeueiiai iaoaaie?cio. Aieea oa?i?i?a niiaeeaaiiy iieiceaa oa aaaaeaiiy naeai?oo iao??th ? noeueoaoo oeeieo ia ?ioaineai?noue i?ioean?a ia?aeeniiai ieeniaiiy e?i?ae?a o oaeyo. ?ioaineo?eaoe?y ieenieo i?ioean?a o ee?oeiao oaa?ei i?ney ia?iaeaeaiiy, ye a?aeiii, coiiaeth? i?aeaeuaiiy eiioeaio?aoe?e eeniaaeo ? a?ae?ieneeueieo ?aaeeeae?a, ye? ? aeoeaaoi?aie i?ioean?a ia?aeeniiai ieeniaiiy e?i?ae?a a oeaieiao. Aaaeeeaeie iieacieeaie ?ioaineaiino? oeueiai i?ioeano ? ai?no ia?aeiieo oa aoi?eiieo i?iaeoeo?a ia?aeeniiai ieeniaiiy e?i?ae?a a ieaci? e?ia?. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aeacothoue ia oa, ui aeey iiaiia?iaeaeaieo oaeyo oa?aeoa?iei ? aenieee ai?no ia?aeiieo ? aoi?eiieo i?iaeoeo?a IIE. Eiioeaio?aoe?? oeeo niieoe a ieaci? e?ia? oaa?ei nooo?ai c?inoathoue i?ioyaii ia?oeo aiaeei aeeooy. Oea ii?aeio?oueny ?c i?aeaeuaiiyi ia?oe?aeueiiai oeneo eenith a e?ia? iiaiia?iaeaeaieo oa aenieith ?ioaineai?noth i?ioean?a i?e?iniiaeueiiai ieeniaiiy i?aai?/ieo noano?ao?a ( Aaa?eeia I.E. e ae?. 1985). Oae, ca?aeii aei ?acoeueoao?a iaoeo aeine?aeaeaiue, o oaeyo ? oa ?? aeine?aeieo a?oi iieacieee eiioeaio?aoe?e a?ae?iia?aeen?a e?i?ae?a oa iaeiiiai-ai ae?aeueaeaa?aeo aoee aeueie, i?ae o oaa?ei eiio?ieueii? a?oie. Iniaeeai oea aeyaeyeiny o oaa?ei aeine?aeieo a?oi i?ney ia?oiai aeiithaaiiy iieiceaa. Oea iiaea na?ae/eoe i?i ?icaeoie a i?aai?ci? oaa?ei aeine?aeieo a?oi ieneaeaoe?eiiai no?ano. Ine?eueee ??aaiue caaacia/aiiy i?aai?cio oaa?ei ?iiaie naeaio oa oeeieo ? aaaeeeaei oaeoi?ii ?aaoeyoe?? aioeieneaeaioiiai noaoono, a ai?no oeeo i?e?iaeaiaio?a a i?aai?ci? oaa?ei cieaeo?oueny i?ney ia?iaeaeaiiy, canoinoaaiiy niieoe Se oa Zn iiaea aooe iaeiei c? niinia?a iaiaaeaiiy ?ioaineaiino? a?eueii?aaeeeaeueieo i?ioean?a o oaa?ei ?aiiueiai a?eo ( Bostedt H., Schramel P., 1990). A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue anoaiiaeaii, ui ?i’?eoe?? naeai?oo iao??th oa eiia?iiaaia aaaaeaiiy oe??? niieoee ?acii ?c noeueoaoii oeeieo 2-aeaiiei oaa?eiai a?aeiia?aeii ?II ? ?V a?oi ni?eyee a??ia?aeiiio ciaioaiith eiioeaio?aoe?? a?ae?iia?aeen?a e?i?ae?a oa iaeiiiaiai ae?aeueaeaa?aeo (IAeA) a ieaci? e?ia? oaeyo ?aiiueiai a?eo (?<0,05; ?<0,01). I?e oeueiio noaoenoe/ii a??ia?aeieo a?aei?iiinoae o ai?no? a?ae?iia?aeen?a ? iaeiiiaiai ae?aeueaeaa?aeo a ieaci? e?ia? oaeyo aeine?aeieo a?oi ii??aiyii aei eiio?ieueii?, o 3- ? 5-aeaiiiio a?oe? ia aeyaeaii. I?ioa, a??ia?aei? ci?ie ai?noo a?ae?iia?aeen?a e?i?ae?a a e?ia? niinoa??aathoueny o 10-aeaiieo oaeyo iaio aeine?aeieo a?oi. A ieaci? e?ia? oaa?ei IV aeine?aeii? a?oie ai?no a?ae?iia?aeen?a e?i?ae?a a??ia?aeii ciaioo?oueny ? ia 20-ee aeaiue aeeooy (?<0,05). ?acii c oei, aeyaeaii nooo?a? a?aei?iiino? i?ae iieacieeaie eiioeaio?aoe?? aoi?eiiiai i?iaeoeoo IIE- iaeiiiaiai ae?aeueaeaa?aeo a ieaci? e?ia? oaeyo II? aeine?aeii? ? eiio?ieueii? a?oi, ui iieyaathoue o a??ia?aeiiio cieaeaii? ai?noo oeueiai iaoaaie?oo a ?o e?ia? i?ae e?iaoeue ia?oi? aeaeaaee aeeooy (?<0,05). A oie naiee /an, ci?ie ai?noo IAeA, ui a?aeaoaathoueny a ieaci? e?ia? oaeyo ?V aeine?aeii? a?oie oeueiai a?eo ? a?eueo ae?acieie. Na?ae/aiiyi oeueiai ? cieaeaiiy eiioeaio?aoe?? IAeA a e?ia? oaa?ei 10- aeaiiiai a?eo aei 3,930,17 iiieue/e (?<0,01). Iacaaaeath/e ia oa, ui ai?no iaeiiiaiai ae?aeueaeaa?aeo o ieaci? e?ia? aeine?aeieo a?oi ia 20-ee aeaiue aeeooy aoa ieae/ei, ii??aiyii c oaa?eiaie eiio?ieueii? a?oie, oey ??cieoey aeyaeeany a??ia?aeiith o oaeyo, yeei, ii?yae c ?i’?eoe??th naeai?oo iao??th, ia?i?aeueii aaiaeeee noeueoao oeeieo. Oaaeeoey 4 - Aieea naeai?oo iao??th ? noeueoaoo oeeieo ia eiioeaio?aoe?th i?iaeoeo?a IIE a ieaci? e?ia? oaeyo? (Mm; n=5-6) A?e A?oieoaa?eieiio?ieue? a?oia?? a?oiaA?ae?iia?aeene e?i?ae?a D/ieeiio?ieueIII a?oiaIV a?oia3-aeaii?0,3250,020,2950,0190,2410,0185-aeaii?0,3180,0230,2270,0170, 2200,01510-aeaii?0,3210,0180,2320,019*0,2240,018**20- aeaii?0,2620,016a0,2210,0170,2130,015*Iaeiiiaee ae?aeueaeaa?ae (iiieue/ie)eiio?ieueIII a?oiaIV a?oia3-aeaii?5,14 0,294,890,194,810,25-aeaii?4,850,214,620,174,450,1910-aeaii?4,980,204,28 0,15*3,930,17**20-aeaii?4,380,15a3,910,12*3,880,13* Oaeei /eiii, o oaeyo ?aiiueiai a?eo niinoa??aa?oueny c?inoaiiy ?ioaineaiino? IIE, ui, i/aaeaeii, a?aeaoaa?oueny ca ?aooiie aeoeaaoe?? eaioethaiaeo a?eueii?aaeeeaeueieo ?aaeoe?e. A oe?eiio, iaea?aeai? ?acoeueoaoe na?ae/aoue i?i aieea ia ?ioaineai?noue i?ioean?a IIE a i?aai?ci? oaa?ei ye a?eiaeo oaeoi??a oae ? oaeoi??a aiae?ae? oa i?e?iaeaiaio?a, cie?aia ?ii?a naeaio oa oeeieo. Aieea oa?i?i?a niiaeeaaiiy iieiceaa oa aaaaeaiiy naeai?oo iao??th ? noeueoaoo oeeieo ia aioeieneaeaioiee noaoon oa iniaeeaino? aia?aaoe/iiai iaoaaie?cio a a?eo?ioeeoao oaeyo. A oiiaao aeoeaaoe?? aa?iaieo iaoaaie?/ieo i?ioean?a a i?aai?ci? iiaiia?iaeaeaieo aaaeeeao ?ieue o caoeno? aioo??oiueiee?oeiieo ? ieaciaoe/ieo iaia?ai a?ae i?iaeoeo?a a?eueii?aaeeeaeueieo i?ioean?a iaeaaeeoue nenoai? aioeieneaeaioiiai caoenoo ee?oei noia?ieneaeaeeniooac?, aeooao?iiia?ieneaeac? (AI) ? aeooao?ii?aaeoeoac? (A?) ( Fairharts S. et al., 1983) . Ca?aeii aei ?acoeueoao?a aeine?aeaeaiue, ??aaiue eaoae?oe/ii? aeoeaiino? oa?iaio?a- aioeieneaeaioii? nenoaie ? iecueeei a a?eo?ioeeoao iiaiia?iaeaeaieo oaa?ei, i?ioa, i?ney ia?iaeaeaiiy aeoeai?noue noia?ieneaeaeeniooace a ee?oeiao oaeyo cia/ii c?inoa? ( Oaae. 5). Aeoeai?noue aeooao?ii?aaeoeoace ? AI a a?eo?ioeeoao oaa?ei aeyaey? oaiaeaioe?th aei c?inoaiiy aaea i?ioyaii ia?oeo 48 aiae i?ney ia?iaeaeaiiy, i?ioa a??ia?aeia ca?eueoaiiy aeoeaiino? oeeo oa?iaio?a niinoa??aa?oueny o 5-aeaiiiio a?oe?.I?e a?aeno?i/aii? aeiithaaiiy iieiceaa aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie a a?eo?ioeeoao oaeyo cieaeo?oueny ( Oaae. 5 ). Cie?aia, oaiaeaioe?th aei cieaeaiiy aeyaey? aeoeai?noue AI ? A? a a?eo?ioeeoao aieiaeoth/eo oaeyo, ui na?ae/eoue i?i i?aeaeuaio iio?aao ?o i?aai?cio a oeae ia??iae o Se2+. Oea iiaea coiiaethaaoenue, c iaei??? noi?iie, cieaeaiiyi ?ioaineaiino? iaaeoiaeaeaiiy naeaio, ui o aaeeeeo e?eueeinoyo i?enooi?e o iieicea? ia?oeo aei?a eaeoaoe??, a c ?ioi? - aeuei ai?noii a i?aai?ci? oaa?ei aeine?aeieo a?oi aetheiei?oeei?ae?a - ?ia?a?oi??a aeoeaiino? - aioeieneaeaioieo oa?iaio?a. A?aeiii, ui noaa?euei?noue iaia?ai ee?oei ? i?aaiae caeaaeeoue a?ae noaio aioeieneaeaioii? nenoaie oa ??aiy caaacia/aiiy i?aai?cio oaa?ei ?iiaie naeaio oa oeeieo (Wendel A., 1992). C iaeyaeo ia oea, iioei?caoe?y aeeaeaiiy oaeyo ca ai?noii Se i Zn - eioaeoi??a oa?iaio?a- aioeieneaeaio?a naeaicaeaaeii? aeooao?iiia?ieneaeace oa Cu, Zn-noia?ieneaeaeeniooace ? iniaeeai aeooaeueieie. Anoaiiaeaii, ui i?e canoinoaaii? naeai?oo iao??th a?aeaoaa?oueny i?ae-aeuaiiy aeoeaiino? oa?iaio?a aeooao?iiiai? nenoaie a?eo?ioeeo?a oaeyo 10- aeaiiiai a?eo. I?e oeueiio, iaeaeuee ??aaiue aeoeaiino? aeooao?iiia?ieneaeace a ii??aiyii? ?c oaa?eiaie eiio?ieueii? a?oie niinoa??aa?oueny ia 20-ee aeaiue aeeooy. ?acii c oei, i?e eiiieaeniiio canoinoaaii? oeeo i?e?iaeaiaio?a a a?eo?ioeeoao oaeyo i?aeaeuaiiy ooieoe?iiaeueii? caeaoiino? aioeieneaeaioii? nenoaie ae?aaeaia a a?eueo?e i???. Iniaeeai oa?aeoa?iei ? aeuee ??aaiue eaoae?oe/ii? aeoeaiino? noia?ieneaeaeeniooace, aeooao?iiia?ieneaeace oa aeooao?ii?aaeoeoace a a?eo?ioeeoao oaa?ei o ii??aiyii? c iieacieeaie, io?eiaieie iai?ee?ioe? ia?oi? oa ae?oai? aeaeaaee i?ney aaaaeaiiy naeai?oo iao??th. Aeacai? ci?ie ? oe?eeii eia?/ieie, ine?eueee iaiao?aeiee aeey eaoae?oe/ii? aeoeaiino? aeooao?iiia?ieneaeace aenieee ??aaiue a?aeiiaeaiiai aeooao?iio caaacia/o?oueny aeooao?ii?aaeoeoacith, eioaeoi?aie yei? ? IAAeI i IAAeOI ( Allen W.M., 1975; Agar N.S. et al., 1975). Ooai?aiiy iae?ia?a?/-ieo niieoe ? a?aeiiaeaieo oi?i i?eioeiai?aeieo eioa?iaio?a, iaio?aeieo aeey a?aeiiaeaiiy aeooao?iio, a a?eo?ioeeoao oaa?ei a?aeaoaa?oueny a i?ioean? ae?eie?oe/iiai oa aiioii?/iiai ?iciaaeo aoaeaaiae?a (Aaa?eeia I.E. e ae?. 1985). A i?ioean? aeine?aeaeaiue anoaiiaeaii, ui aeey a?eo?ioeeo?a iiaiia?iaeaeaieo oaeyo oa?aeoa?iith ? aeniea aeoeai?noue oa?iaio?a ae?eie?co ? iaioicioinoaoiiai ooioo. I?ioyaii 1-? aeiae i?ney ia?iaeaeaiiy aeoeai?noue aaenie?iace a a?eo?ioeeoao oaeyo a??ia?aeii c?inoa? (p<0,05) ? caeeoa?oueny aenieith aei10-aeaiiiai a?eo. Ooai?aiee a aaenie?iaci?e ?aaeoe?? aetheici-6-oinoao cia/iith i??ith ooee?co?oueny a ?aaeoe?yo iaioicioinoaoiiai ooioo, ia ui aeaco? aeoeaaoe?y aetheici-6-oinoaoaeaa?ae?iaaiace a a?eo?ioeeoao oaeyo eiio?ieueii? a?oie a ia??iae? c 1-? ii 10-o aeiae i?ney ia?iaeaeaiiy. Aaaeeeao ?ieue a caaacia/aii? a?aeiia?aeiiai ??aiy iaoaaie?/ieo i?ioea-n?a a a?eo?ioeeoao oaa?ei a?ae?a?athoue ie?ai? iacai?ii? i?e?iaeaiaioe, cie?aia, oeeie ? naeai. Oae, i?ney aaaaeaiiy naeaio ? oeeieo a a?eo?i?aeieo ee?oeiao 10-aeaiieo oaeyo c?inoa? ?ioaineai?noue ?icuaieaiiy aetheice ae?eie?oe/iei oeyoii, i?i ui na?ae/eoue a??ia?aeia i?aeaeuaiiy aeoeaiino? eeth/iaiai oa?iaioo oeueiai i?ioeano - aaenie?iace (p<0,05). ??aaiue ieeniaiiy iiiinaoa?eaeo a ?aaeoe?yo iaioicioinoaoiiai oeyoo, i/aaeaeii, nooo?ai ia ci?ith?oueny , ia ui aeaco? a?aeiinii noaa?eueia aeoeai?noue aetheici-6-oinoaoaeaa?ae?iaaiace. Oaaeeoey 5. - Aieea naeai?oo iao??th ? noeueoaoo oeeieo ia aeoeai?noue aioeieneaeaioieo oa?iaio?a a a?eo?ioeeoao oaeyo. (Mm; n=5-6) A?e A?oiaoaa?eieiio?ieue??? a?oia?V a?oiaNoia?ieneaeaeeniooaca oi. iae./ oa. ia a?eeo3-aeaii?18,61,8518,91,419,11,25-aeaii?16,81,316,51,318,11,210-aeaii ?13,040,8a15,61,116,960,92*20-aeaiue13,10,8514,10,6316,380,95*Aeooao?iii a?ieneaeaca ASSA / oa. ia a?eeo3-aeaii?23,12,325,62,824,92.05-aeaii?34,52,2b30,12,129,82,310-aeaii ?34,2 1,842,4 2,0*43,5 2,1*20-aeaii?34,0 1,746,92,3**49,21,9***Aeooao?i?aaeoeoaca ASH / oa. ia a?eeo3- aeaii?3,82 0,24a4,15 0,304,210,285-aeaii?3,6 0,263,84 0,274,080,2510-aeaii?3,37 0,163,99 0,21*4,120,22*20-aeaii?3,52 0,183,93 0,224,110,20* Oaeei /eiii i?aaenoaaeai? aeai? aeathoue i?aenoaao i?iaiicoaaoe ni?eyoeeaee aieea ?i’?eoe?e naeai?oo iao??th oa aaaaeaiiy oe??? niieoee a eiiieaen? ?c noeueoaoii oeeieo ia aeeoo?caeaoi?noue oa aioeieneaeaioiee noaoon oaeyo o iaiiaoaeueiiio ia??iae?. Oeae aieea cia/iith i??ith aeyaey?oueny o i?aeaeuaii? ooieoe?iiaeueii? aeoeaiino? aioeieneaeaioii? nenoaie oa ??aiy aia?aaoe/ieo i?ioean?a a a?eo?i?aeieo ee?oeiao, a a oe?eiio, ni?ey? i?aeaeuaiith ??aiy aaeaioaoe?eieo i?ioean?a a i?aai?ci? oaa?ei a iaiiaoaeueiiio ia??iae? ?icaeoeo. AENIIAEE 1. I?ioean aaeaioaoe?? i?aai?cio iiaiia?iaeaeaieo oaeyo aei iiaeo oiia ?nioaaiiy i?e ??cieo oa?i?iao aeiithaaiiy iieiceaa ca’ycaiee c oi?ioaaiiyi ai?iiiaeueii-noano?aoieo iaoai?ci?a ?aaoeyoe?? iaoaaie?cio. Aaaeeeao o/anoue o ooieoe?iioaaii? oeeo iaoai?ci?a a?ae?a?athoue niieoee oeeieo ? naeaio. Io?eiaii iia? aeai?, ye? iiaeooue aooe oai?aoe/iith iniiaith aeey ?ic?iaee no/anieo nenoai aiae?ae? ? oo?eiaiiy iiaiia?iaeaeaieo oaeyo c iaoith i?aeaeuaiiy ?o aeeoo?caeaoiino? ? caa?aaeaiiy a ?aiiueiio a?oe?. 2. Iiaiia?iaeaeai? oaeyoa (aei i?eeiio iieiceaa) oa?aeoa?ecothoueny iecueeei ai?noii ?inoe?io oa aenieeie eiioeaio?aoe?yie ei?oecieo ? oe?ai?aeieo ai?iii?a a ieaci? e?ia?, iecueeei ai?noii aetheice ? IAAEE. 3. I?e aieiaeoaaii? o oaa?ei niinoa??aa?oueny a?ii?inoe?iai?y oa ieae/ee, ii??aiyii c eiio?ieueiith a?oiith oaa?ei, ??aaiue oe?ai?aeieo ai?iii?a a e?ia? ( p<0,05). 4. Aeiithaaiiy iieiceaa aeoeao? ?ie?aoi?io ae?yeuei?noue - ee?oei i?aeoeoieiai? caeice ? i?aeaeuo? ooieoe?iiaeueio aeoeai?noue ueoiaeaeii? caeice o iiaiia?iaeaeaieo oaeyo, ia ui aeaco? i?aeaeuaiiy eiioeaio?aoe?e ?inoe?io (p<0,001) ? oe?ieneio ( p<0,05) a ieaci? oaa?ei. 5. I?ioyaii ia?oeo aei?a i?ney ia?iaeaeaiiy a ieaci? oaeyo niinoa??aa?oueny cia/ia ciaioaiiy eiioeaio?aoe?e ei?oecieo ( p<0,001) ? oe?ieneio (p<0,05) oa c?inoaiiy ai?noo ?inoe?io ( p<0,001) ? o?eeiaeoe?ii?io (p<0,05), yea a?aeaoaa?oueny iaeii/anii c? ci?iaie eiioeaio?aoe?e aetheice, IAAEE, a?eueieo ai?iieeneio, eaeoaoo ? i??oaaoo a e?ia?. 6. I?ney aaaaeaiiy naeai?oo iao??th o oaeyo ci?ith?oueny ni?aa?aeiioaiiy i?ae ai?noii oe?ai?aeieo ai?iii?a a ieaci?, ui coiiaeth?oueny c?inoaiiyi ai?noo o?eeiaeoe?ii?io ( p<0,05; p<0,001) oa cieaeaiiyi eiioeaio?aoe?? oe?ieneio ( p<0,05). 7. A ia??iae? a?ae ia?iaeaeaiiy aei 10-aeaiiiai a?eo a a?eo?ioeeoao oaeyo niinoa??aa?oueny ?ioaineo?eaoe?y ?icuaieaiiy aetheice a ?aaeoe?yo ae?eie?co ? iaioicioinoaoiiai oeyoo; i?aeaeuaiiy eiioeaio?aoe?? 2,3-AeOA (p<0,05); aeoeaaoe?y oa?iaio?a aioeieneaeaioii? nenoaie: noia?ieneaeaeeniooace, aeooao?iiia?ieneaeace ? aeooao?ii?aaeoeoace (p<0,05) 8. I?ae aieeaii ?ii?a naeaio a ieaci? oaa?ei i?aeaeuo?oueny eiioeaio?aoe?y ?inoe?io (p<0,05; p<0,001) oa ciaioo?oueny ai?no ei?oecieo (p<0,05). Canoinoaaiiy naeai?oo iao??th a eiiieaen? c noeueoaoii oeeieo aaaea aei i?aeaeuaiiy eiioeaio?aoe?e o?eeiaeoe?ii?io (p<0,05; p<0,001) oa ?inoe?io (p<0,05; p<0,001) ? cieaeaiiy ai?noo ei?oecieo (p<0,05; p<0,001) a ieaci? oaeyo, ni?ey? i?aeaeuaiith ooieoe?iiaeueii? aeoeaiino? oa?iaioieo aioeieneaeaio?a - aeooao?iiia?ieneaeace ? noia?ieneaeaeeniooace a a?eo?ioeeoao (p<0,05; p<0,001; p<0,0001). 9. I?ney aioo??oiueii'ycaaiai aaaaeaiiy naeai?oo iao??th o oaeyo 10- 20- aeaiiiai a?eo cieaeo?oueny ai?no a?ae?iia?aeen?a e?i?ae?a oa iaeiiiaiai ae?aeueaeaa?aeo a ieaci? (p<0,05; p<0,001) ? i?aeaeuo?oueny aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie (p<0,05; p<0,01; p<0,0001). I?aeoe/i? ?aeiiaiaeaoe??: C iaoith i?aeaeuaiiy ooieoe?iiaeueii? aeoeaiino? nenoaie aioeieneaeaioiiai caoenoo ee?oei, aeoeaaoe?? iaoai?ci?a ?aaoeyoe?? noano?aoiiai caaacia/aiiy iaoaaie?/ieo i?ioean?a oa ei?aeoe?? ii?ooaiue ai?iiiaeueiiai noaoono a i?aai?ci? ?aeiiaiaeo?oueny aaaaeaiiy a ?aoe?ii oaeyo ?aiiueiai a?eo niieoe oeeieo ( aei 80 ia Zn/ ea nooi? iane) ia oii? ?i’?eoe?e naeai?oo iao??th (c ?ic?aooieo 0,075 ia naeaio/ ea iane). NIENIE ?IA?O IIOAE?EIAAIEO II OAI? AeENA?OAOe?? 1. E?aeooi A.A., Aeai/oe A.A., Ni?oeinueeee A.A.Ai?iiiaeueiee noaoon aaeeei? ?iaaoi? ooaeiae o ?aii?e iinoiaoaeueiee ia??iae iioiaaiaco.// Iaoeiai-oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1997. - 19, ? 1.- n. 35-38. ( Aeena?oaioii i?iaaaeaii aenia?eiaioaeuei? aeine?aeaeaiiy, noaoenoe/io ia?iaeo, aiae?c ? iienaiiy io?eiaieo ?acoeueoao?a). 2. E?aeooi A.A., Ni?oeinueeee A.A. Aeeiai?ea ai?noo ?inoe?io, ei?oecieo oa noano?ao?a aia?aaoe/iiai iai?io a e?ia? oaeyo.// Iaoeiai-oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1997. - 19, ? 1. - n. 43-45. ( Aeena?oaioii i?iaaaeaii aenia?eiaioaeuei? aeine?aeaeaiiy, noaoenoe/io ia?iaeo, aiae?c ? iienaiiy io?eiaieo ?acoeueoao?a) 3. E?aeooi A.A., Aiaaeaiia I.A., Ni?oeinueeee A.A. Ai?iiiaeueiee ? noano?aoiee noaoon iiaiia?iaeaeaieo oaeyo a ia??iae iiei/iiai aeeaeaiiy.// A?niee aa?a?ii? iaoee.- 1998.- ? 10.- 34-37. ( Aeena?oaioii i?iaaaeaii aenia?eiaioaeuei? aeine?aeaeaiiy, noaoenoe/io ia?iaeo, aiae?c ? iienaiiy io?eiaieo ?acoeueoao?a) 4. Ni?oeinueeee A.A., E?aeooi A.A., Aioiiye A.E. Iniaeeaino? aia?aaoe/iiai iaoaaie?cio a a?eo?ioeeoao aaeeei? ?iaaoi? ooaeiae ia ie?aieo noaae?yo iinoiaoaeueiiai iioiaaiaco. // Iaoe.-oao. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i??- 1996,-18, ?1,- n. 24-27. ( Aeena?oaio i?eeiaa o/anoue o iinoaiiaoe? aeine?aeo, a?aeai?? iaoa??aeo, aeine?aeaeaii? aeoeaiino? oa?iaio?a ? eiioeaio?aoe?? iaoaaie?o?a ae?eie?co a a?eo?ioeeoao oaeyo, aiae?c? io?eiaieo ?acoeueoao?a) 5. E?aeooi A.A., Ni?oeinueeee A.A.Oi?ioaaiiy noano?aoii-ai?iiiaeueieo iaoai?ci?a ?aaoeyoe?? o aaeeei? ?iaaoi? ooaeiae a ia??iae iiaiia?iaeaeaiiino?.// Oace aeiiia?aeae VII Oe?a?inueeee a?io?i?/iee c’cae.- 1997. n.71-72. 6. Ni?oeinueeee A.A., Aioiiye A.E., E?aeooi A.A., ?ne?a ?.ss., Ao/ei I.I., Aaeueeianueeee A.A. Aeaye? aniaeoe i?ia?aeueiiai aeeaeaiiy oaa?ei o iaiiaoaeueiiio ia??iae?. //Oace aeiiia?aeae i?aeia?iaeii? eiioa?aioe?? “ A?ieia?/i? iniiae aeeaeaiiy n?euenueeiainiiaea?nueeeo oaa?ei “ 15-18 aa?aniy 1998 ?., n.21 7. Aeai/oe A.A., E?aeooi A.A., Ee/oi ?.A., A?uo? I.?., ss?aiei ?.I., Niieyi?iia E.A. ?ieue ai?iiiaeueieo oaeoi??a a ?aaoeyoe?? i?ioean?a a?eueii?aaeeeaeueiiai ieeniaiiy a ia??iae iaiiaoaeueii? aaeaioaoe??.// Oacu ??? iaaeaeoia?. neiiic. “ Aeieiae/aneea iaoaieciu noa?aiey”, Oa?ueeia 19-21 iay 1998 a.- Oa?ueeia.- 1998 -n.62. 8. Ni?oeinueeee A.A., Aioiiye A.E., ?ne?a ?.ss., Ao/ei I.I., E?aeooi A.A., Aeai/oe A.A., Aaeueeianueeee A.A. Aeaeia? iniaeeaino? ai?iiiaeueiiai noaoono aaeeei? ?iaaoi? ooaeiae ? naeiae a ia??iae iaiiaoaeueii? aaeaioaoe??.// XV c’?cae Oe?. o?c?ie. o-aa.: Oace aeii.- O?c?ie. aeo?i.-1998.-44, ? 33.-n. 239. AIIOAOe?? E?aeooi A.A. Iaoaaie?/iee ? aioeieneaeaioiee noaoon i?aai?cio aaeeei? ?iaaoi? ooaeiae a ?aiiueiio iinoiaoaeueiiio ia??iae? iioiaaiaco oa oaeoi?e eiai ?aaoeyoe??. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa n?euenueeiainiiaea?nueeeo iaoe ca niaoe?aeuei?noth 03.00.04 - a?io?i?y. ?inoeooo caiea?ianoaa ? a?ieia?? oaa?ei OAAI, Euea?a, 1999 Aeena?oaoe?y i?enay/aia c'ynoaaiith a?ieia?/ieo iniia i?iaeoeoeaiino? ? aeeoo?caeaoiino? aaeeei? ?iaaoi? ooaeiae ia ?aii?o noaae?yo iinoiaoaeueiiai ?icaeoeo. Iieacaii, ui i?ioyaii ia?oeo aei?a i?ney ia?iaeaeaiiy a i?aai?ci? aaeeei? ?iaaoi? ooaeiae a?aeaoaathoueny nooo?a? ci?ie a eiioeaio?aoe?yo ai?iii?a, ye? iieyaathoue o ciaioaii? eiioeaio?aoe?? ei?oecieo ? oe?ieneio oa c?inoaii? ai?noo ?inoe?io ? o?eeiaeoe?ii?io. Anoaiiaeaiiy a?aeiia?aeieo ni?aa?aeiioaiue i?ae ai?noii ai?iii?a a?aeaoaa?oueny iaeii/anii c? ci?iaie eiioeaio?aoe?? aetheice, IAAEE, a?eueieo ai?iieeneio, eaeoaoo oa i??oaaoo a e?ia?. Oi?ioaaiith ai?iiiaeueii-noano?aoieo iaoai?ci?a ?aaoeyoe?? aioo??oiueiee?oeiiiai iaoaaie?cio oa noaa?e?caoe?? aioeieneaeaioiiai noaoono ee?oei ni?ey? a/ania io?eiaiiy oaa?eiaie iaoa?einueeiai iieiceaa. C’yniaaii aaaeeeao ?ieue i?e?iaeaiaio?a Se ? Zn o ?aaoeyoe?? iaoaaie?/iiai oa aioeieneaeaioiiai noaoono oaeyo. Iieacaii, ui aaaaeaiiy noeueoaoo oeeieo a ?aoe?ii oaeyo o eiiieaen? c naeai?oii iao??th iiceoeaii aieeaa? ia ?o ai?iiiaeueiee ? noano?aoiee noaoon ? noi?iaiaeaeo?oueny aaeaeaaoiith ?aaeoe??th aioeieneaeaioii? nenoaie a?eo?ioeeo?a ia?eoa??eii? e?ia?. Eeth/ia? neiaa: aaeeea ?iaaoa ooaeiaa, ai?iiie, iaoaaie?ci, aioe-ieneaeaioia nenoaia, i?e?iaeaiaioe, aeeaeaiiy, iioiaaiac. E?aeooi A.A. Iaoaaiee/aneee e aioeieneaeaioiue noaoon i?aaiecia e?oiiiai ?iaaoiai neioa a ?aiiai iinoiaoaeueiii ia?eiaea iioiaaiaca e oaeoi?u aai ?aaoeyoeee. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa naeueneioicyenoaaiiuo iaoe ii niaoeeaeueiinoe 03.00.04 - aeioeiey. Einoeooo caiaeaaeaeey e aeieiaee aeeaioiuo OAAI, Eueaia, 1999 Aeenna?oaoeey iinayuaia eco/aieth aeieiae/aneeo iniia i?iaeoeoeaiinoe e?oiiiai ?iaaoiai neioa ia ?aiieo noaaeeyo iinoiaoaeueiiai ?acaeoey. A i?ioeanna enneaaeiaaiee onoaiiaeaii, /oi iieaeoey?iua iaoaieciu iaiiaoaeueiie aaeaioaoeee aeeth/atho ia?ano?ieeo iiiaeo caaiueaa iaoaaieecia a i?aaiecia e a cia/eoaeueiie noaiaie caaenyo io no?ieia auiaeaaiey iieiceaa e o?iaiy iaania/aiiinoe aeeaioiuo ?aiiaai aic?anoa eiiaie naeaia e oeeiea. I?eaaaeaiiua aeaiiua naeaeaoaeuenoaotho i oii, /oi iiai?iaeaeaiiua oaeyoa ( aei i?eaia iieiceaa) oa?aeoa?ecothony ieceei niaea?aeaieai einoeeia i?e aunieeo eiioeaio?aoeeyo ei?oeciea e oe?aieaeiuo ai?iiiia a ieacia e?iae. I?e yoii iaaethaeaaony ieceia niaea?aeaiea iniiaiuo noano?aoia yia?aaoe/aneiai iaiaia - aetheicu e IYAEE, a oaeaea aunieea eiioeaio?aoeee eaeoaoa, ie?oaaoa e aetheiaaiiuo aieiieeneio. Auiaeaaiea iieiceaa aeoeae?oao eie?aoi?ioth aeayoaeueiinoue -eeaoie iiaeaeaeoaei/iie aeaeacu e iiauoaao ooieoeeiiaeueioth aeoeaiinoue ueoiaeaeiie aeaeacu, i /ai naeaeaoaeuenoaoao iiauoaiea o?iaiy einoeeia e oe?aieaeiuo ai?iiiia. I?e yoii, ia i?ioyaeaiee ia?auo aeiae iinea ?iaeaeaiey, aianoa n iiauoaieai eiioeaio?aoeee aetheicu e ?acaaoaeaiiuo aieiieeneio cia/eoaeueii nieaeaaony niaea?aeaiea eaeoaoa e ie?oaaoa (? 0,05- 0,001). Ia i?ioyaeaiee ia?auo /ania iinea ?iaeaeaiey i?ienoiaeeo eioaineaiia ia?anoaiea niaea?aeaiey aeae?iia?aeenae eeieaeia e iaeiiiaiai aeeaeueaeaaeaea, oiaaea eae ooieoeeiiaeueiay aeoeaiinoue aioeieneaeaioiuo oa?iaioia a y?eo?ioeeoao oaeyo aeinoeaaao iaeaunoeo iieacaoaeae ia 3-e e 5-a nooee iinoiaoaeueiie aeecie. Oi?ie?iaaiea ai?iiiaeueii- noano?aoiuo iaoaieciia ?aaoeyoeee aioo?eeeaoi/iiai iaoaaieecia e noaaeeecaoeee aioeieneaeaioiiai noaoona eeaoie niinianoaoao naiaa?aiaiiia iieo/aiea aeeaioiuie iaoa?eineiai iieiceaa. Caaea?aeea auiaeaaiey oaeyoai iieiceaa iaaeaaii?eyoii aeeyao ia ai?iiiaeueiue noaoon aeeaioiuo e aaaeao, n iaeiie noi?iiu, e oiaiueoaieth o?iaiy noano?aoiiai iaania/aiey eeaoi/iuo ooieoeee, a n ae?oaie - e nieaeaieth aeoeaiinoe oa?iaioia aioe-ieneaeaioiie nenoaiu, aucuaay ?acaeoea a i?aaiecia ieneaeaoeeiiiiai no?anna. I?e eco/aiee aeeyiey eiiia naeaia e oeeiea ia iieacaoaee iaoaaieecia iieacaii, /oi aeeyiea yoeo iee?iyeaiaioia naycaii n eciaiaieyie ai?iiiaeueiiai e noano?aoiiai noaoona oaeyo, a iaoaaiee/aneea yooaeou yoeo iee?iyeaiaioia iiaoo ea?aoue aaaeioth ?ieue a iaoaieciao iinoiaoaeueiie aaeaioaoeee aeeaioiuo. Onoaiiaeaii, /oi iinea aaaaeaiey naeaieoa iao?ey o oaeyo eciaiyaony niioiioaiea iaaeaeo niaea?aeaieai oe?aieaeiuo ai?iiiia a i?aaiecia, /oi nii?iaiaeaeaaony aic?anoaieai niaea?aeaiey o?eeiaeoe?iieia e nieaeaieai eiioeaio?aoeee oe?ieneia a ieacia e?iae. I?eaaaeaiiua aeaiiua naeaeaoaeuenoaotho i oii, /oi iiae aeeyieai eiiia naeaia a ieacia e?iae aeeaioiuo aic?anoaao eiioeaio?aoeey einoeeia e oiaioaaony eiioeaio?aoeey ei?oeciea. Iinea aioo?eiuoa/iiai aaaaeaiey naeaieoa iao?ey o oaeyo 10- aeiaaiiai aic?anoa nieaeaaony niaea?aeaiea aeae?iia?aeenae eeieaeia e iaeiiiaiai aeeaeueaeaaeaea a ieacia, aic?anoaao aeoeaiinoue oa?iaioia aioeieneaeaioiie nenoaiu a y?eo?ioeeoao. Aaaaeaiea noeueoaoa oeeiea a ?aoeeii oaeyo a eiieaena n eiaeoeeae naeaieoa iao?ey iieiaeeoaeueii aeeyao ia eo ai?iiiaeueiue noaoon, /oi nii?iaiaeaeaaony aaeaeaaoiie ?aaeoeeae aioeieneaeaioiie nenoaiu y?eo?ioeeoia ia?eoa?e/aneie e?iae. Iieo/aiiua ?acoeueoaou naeaeaoaeuenoaotho i oeaeaniia?aciinoe aaaaeaiey a ?aoeeii oaeyo ?aiiaai aic?anoa niaaeeiaiee oeeiea ( aei 80 ia Zn / ea nooiai aauanoaa) ia oiia eiuaeoeee naeaieoa iao?ey ( ec ?an/aoa 0,075 ia Se / ea ianu ) n oeaeueth iiauoaiey ooieoeeiiaeueiie aeoeaiinoe nenoaiu aioeieneaeaioiie caueou eeaoie e ei??aeoeee ia?ooaiee ai?iiiaeueiiai noaoona a i?aaiecia aeeaioiuo. Eeth/aaua neiaa: e?oiiue ?iaaoue neio, ai?iiiu, iaoaaieeci, aioeieneaeaioiay nenoaia, iee?iyeaiaiou, ieoaiea, iioiaaiac. Krektun B.V. Metabolic and antioxidant status of cattle organism in early postnatal period of ontogenesis and factors of its regulation. Manuscript. Candidate’s thesis of agricultural science by speciality 03.00.04 - biochemistry.- Institute of Agriculture and Animal Biology of UAAS, Lviv, 1999. Candidate’s thesis is dedicated to elucidation of biological basis of cattle productivity in early postnatal period of ontogenesis. It was established, that significant changes in concentrations of hormones consist in decrease in cortisol and thyroxine concentrations and increase in insulin and triiodothyronine concentrations in blood plasma of cattle during early period after the birth. The changes in hormonal status and alterations in glucose, NEFA, free amino acids concentrations in blood are greatly connected. The processes of formation of hormonal-substrate mechanism of metabolism regulation and antioxidant status stabilization are conditioned by receiving maternal colostrum in time. The favourable influence of trace elements (selenium and zinc) on metabolic and antioxidant status of calves was established. It was demonstrated, that administration of zinc sulfate potentiated effects of sodium selenite on hormonal and substrate status of calves and provided increase in functional activity of antioxidant systems. Key words: cattle, hormone, metabolism, antioxidant system, trace elements, nutrition, ontogenesis.

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