OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

NA?A??IEI NA?A?E IEEIEAEIAE*

OAeE 618.7-002-08:612.015.11-13-017.1

IAOAAIE?*I?, I?E?IAAIIAeEIAI?*I?OA ?IOIIEIA?*I? II?OOAIIss A IAOIAAIAC?
I?NEssIIEIAIAI? ?IOAEOe??O II?IAe?EUe OA ?O EI?AEOe?ss

14.01.01 – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyeaiaeeaeaoa
iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?, IIC
Oe?a?ie.

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, i?ioani?

*oa A?eoi? Aaneeueiae/

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee eaoaae?e
aeooa?noaa ? a?iaeieia?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

I?ciaa Iaoae?y Ieeiea?aia

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aeooa?noaa oa a?iaeieia?? oaeoeueoaoo oaeineiiaeaiiy e?ea??a

aeieoi? iaaee/ieo iaoe, i?ioani?

Ua?aeia Ieeiea Ieaenaiae?iae/

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aeooa?noaa oa a?iaeieia?? ? 1

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i. I.I. Aiaiiieueoey, eaoaae?a aeooa?noaa ? a?iaeieia?? ? 1, IIC
Oe?a?ie, i. Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny «__25__» eenoiiaaea 1999 ?. i 11
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.01 o
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a,
i?. Eai?ia, 4)

C aeena?oaoe??th iiaeia iciaeiieoeny a iaoeia?e a?ae?ioaoe?
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a,
i?. Eai?ia, 4)

Aaoi?aoa?ao ?ic?neaiee » 25″ aeiaoiy 1999 ?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio _____________ Oaiueei I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. I?ioyaii inoaii?o ?ie?a a Oe?a?i? ia oii?
cieaeaiiy ia?iaeaeoaaiino? niinoa??aa?oueny oaiaeaioe?y aei c?inoaiiy
/anoioe ai?eii-caiaeueieo oneeaaeiaiue (ACO) i?neyiieiaiaiai ia??iaeo,
yea aeinyaa? 11–22% a?ae caaaeueii? e?eueeino? iieia?a
(?.A. Aiaaoe?ueiaa, 1998; ss.I. Nieuenueeee, 1996; A.E. Noaiaie?anueea,
1998). O no?oeoo?? iaoa?einueei? caoai?thaaiino? i?neyiieiaiaa ?ioaeoe?y
(I?) caeia? 1-2 i?noea, a o no?oeoo?? iaoa?einueei? nia?oiino? – 3-4
(A.I. Aaioeeianueeee, 1997; ?.?. Cae, 1997).

Ia?aaoaaiiy o noaoe?iia?? ii?iae?eue c ?ioaeoe?eieie oneeaaeiaiiyie
iio?aao? ?noioieo iaoa??aeueieo aeo?ao (?.A. Aiaaoe?ueiaa, 1997;
A.E. Ao?oiaee, 1995), i?e oeueiio oaeiae iia??oothoueny oiiae oo?eiaiiy
? ?icaeoeo iiaiia?iaeaeaiiai (O.A. Niaeoia, 1995). Oiio a no/anieo
aeiiii?/ieo oa aeaiia?ao?/ieo oiiaao, ui neeaeeny a Oe?a?i?,
i?io?eaeoeea e i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy i?neyiieiaiaeo
naioe/ieo caoai?thaaiue ? ia o?eueee ee?i?/iith, aea ? aaaeeeaith
nioe?aeueii-aeiiii?/iith i?iaeaiith (I.A. Aieaea, 1996).

Aaaaoi aaoi??a i?aee?aneththoue i?ia?aeio ?ieue noaio ?ioi?oaoo oa
nenoaie i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino? (IA?) o ?icaeoeo
I? (A.I. Caii?iaeai, I.A. Oaeo, I.I. I?ciaa, 1992; A.A. *oa oa ni?aaao.,
1997). O ?yae? i?aoeue anoaiiaeaii oi?ioaaiiy o ii?iae?eue, ye?
no?aaeaeathoue ia ACO, ii?ooaiue ?ioiieia?/iiai aiiainoaco
(TH.?. I?eieaiei, I.Ae. Ai?iaeei, 1997). I?ioa, ?ioeii? iaoai?cie
?icaeoeo ?ioiieo ?iceaae?a caeeoathoueny iaaeinoaoiuei aeine?aeaeaieie.
Ieceith aeine?aeiee?a i?aee?aneth?oueny ?noioia cia/aiiy neiae?iio
“iaoaaie?/ii?” ?ioieneeaoe??, aeoeaaoe?? ia?ieneaeaoe?? e?i?ae?a ?
?iceaae?a i?e?iaaiiaeeiai?ee a iaoiaaiac? ?ioaeoe?eiiai i?ioeano
(A.I. Ei?ioeee, A.A. Aanee?i/oe, 1988; E.E. A?iiaoaanueea, 1996). I?ioa
aei ianooiiiai /ano iaaeinoaoiuei aea/aii aca?iica’ycie i?ae
iaoaaie?/ieie, i?e?ioee?eoeyoi?ieie oa ?ioiieia?/ieie ci?iaie i?e
aeooa?nueeeo ai?eii-caiaeueieo caoai?thaaiiyo. ?nioth/? iaoiaee
e?eoaaiiy i?neyiieiaiai? ?ioaeoe?? ia caaaeaee a?aoiaothoue ci?ie
iaoaaie?/ieo, i?e?ioee?eoeyoi?ieo oa ?ioiieo iieaciee?a, a oiio a
aeayeeo aeiaaeeao ? iaaeinoaoiuei aoaeoeaieie ? iio?aaothoue
iiaeaeueoiai oaeineiiaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue a?aeiia?aeii aei ?anioae?eainueei? eiiieaenii?
i?aea?aeii/i? i?ia?aie “I?io?eaeoeea caoai?thaaiue oa oi?ioaaiiy
caei?iaiai niiniao aeeooy ianaeaiiy Oe?a?ie ia ia??iae aei 2000 ?ieo” oa
iniiaiiai ieaio IAe? Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?
? o?aaiaioii IAe? “?ic?iaea nenoaie ?ioiieia?/iiai iii?oi?eiao oa
?ioii?aaa?e?oaoe?? ?ia?oiee?a iniiaieo aaeocae aaeeeiai i?iieneiaiai
ae?iaieoeoaa ? a?oi ?eceeo ianaeaiiy i?iieneiai? ciie Aeiiaano”
(? aea?ae?a?no?aoe?? 019000242).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei aea/aiiy
iaoiaaiaoe/ii? ?ie? iaoaaie?/ieo, i?e?ioee?eoeyoi?ieo oa ?ioiieo
?iceaae?a o ?icaeoeo ai?eii-caiaeueieo caoai?thaaiue ioa?ia??th oa
ee?i?ei-iaoiaaiaoe/ia iaa?oiooaaiiy caniao e?eoaaiiy ii?iae?eue c
i?neyiieiaiaith ?ioaeoe??th c aeeth/aiiyi ia?i?aeeio, oieioa?ieo
aoeaoaoo oa i?aia?ao?a oeiona.

Aeey ?aae?caoe?? aeaii? iaoe aeine?aeaeaiiy iinoaaeai? ianooii?
eiie?aoi? caaea/?:

1. Aeine?aeeoe ae?aaeai?noue neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??,
aeoeai?noue ia?ieneaeaoe?? e?i?ae?a oa noai nenoaie aioeieneaeaioiiai
caoenoo o ii?iae?eue c I?.

2. I?iaiae?coaaoe oa?aeoa? i?e?iaaiiaeeiai?/ieo ?iceaae?a i?e ACO
ioa?ia??th.

3. Aea/eoe noai ?ioi?oaoo oa aeaye? iieacieee i?e?iaeii?
aioe?ioaeoe?eii? ?acenoaioiino? o iaoe??ioie c I?.

4. Aecia/eoe ee?i?/io aoaeoeai?noue eiiieaeno ia?i?aeeio, oieioa?ieo
aoeaoaoo oa i?aia?ao?a oeiona i?e ?o ?iaeea?aeoaeueiiio i?aeai?? a
oanoao ?n v?tro i?e e?eoaaii? ii?iae?eue c i?neyiieiaiaeie ACO.

5. Anoaiiaeoe aieea cai?iiiiiaaiiai caniao e?eoaaiiy ia aeeiai?eo
iaoaaie?/ieo iieaciee?a, noai i?e?iaaiiaeeiai?ee oa ?ioiieia?/iee noaoon
o iaoe??ioie c I?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Io?eiai? aeai? i?i nooi?iue
ae?aaeaiino? neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??,
i?e?iaaiiaeeiai?/ieo ii?ooaiue oa ai?no i?e?iaeiiai ?ia?aoth/iai oaeoi?a
o iaoe??ioie c ACO ioa?ia??th.

Aecia/ai? iniaeeaino? ?iceaae?a ?ioi?oaoo oa i?e?iaeii? aioe?ioaeoe?eii?
?acenoaioiino? o ii?iae?eue c I?.

Aeine?aeaeaii aca?iica’ycie aaee/eie e?iaiao?aoe, oyaeeino?
i?neyiieiaiai? ?ioaeoe?? c ae?aaeai?noth iaoaaie?/ieo, ?ioiieia?/ieo e
i?e?ioee?eoeyoi?ieo ?iceaae?a.

Anoaiiaeaii iaoiaaiaoe/ia cia/aiiy i?e?iaeiiai ?ia?aoth/iai oaeoi?a,
ci?i iaoaaie?/iiai aiiainoaco ? ii?ooaiue i?e?iaaiioee?eoeyoe?? o
oi?ioaaii? aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? o ii?iae?eue c
i?neyiieiaiaeie ?ioaeoe?eieie caoai?thaaiiyie.

Iaoiaaiaoe/ii iaa?oioiaaia aeioe?euei?noue aeeth/aiiy aei eiiieaenii?
oa?ai?? I? cania?a c aioeieneaeaioiith ? aia?ii?ioaeoi?iith ae?yie oa
i?aia?ao?a oeiona (c ?o ?iaeea?aeoaeueiei i?aeai?ii a oanoao in vitro).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? e?eoa??? aeey
i?iaiicoaaiiy ?icaeoeo i?neyiieiaiaeo ACO c aeei?enoaiiyi ?ioiieia?/ieo
oa a?io?i?/ieo aeine?aeaeaiue. Oae, i?e ai?no? “na?aaei?o iieaeoe” a
ne?iaaooe? e?ia? ii?iae?ee? 0,69 a/e e aeua oa cia/aii? ?iaeaeno
?ia?a?oe?? 1,5 ? a?eueoa iiaeia i?iaiicoaaoe c a??ia?aei?noth 85,4±3,2%
aeieeiaiiy i?neyiieiaiaiai caoai?thaaiiy.

Aecia/ai? ?ioiieia?/i? oa a?io?i?/i? iieacieee, aeeiai?ea yeeo aeicaiey?
ioe?ithaaoe aoaeoeai?noue i?iaaaeaiiai e?eoaaiiy ii?iae?eue c I?, a naia
ciaioaiiy ?iaeaeno ?ia?a?oe?? aei 1,1-1,2 oa ciaioaiiy ai?noo “na?aaei?o
iieaeoe” aei 0,58-0,60 a/e.

?ic?iaeaia ? ii?aoeueiaaia ?aoe?iiaeueia, iaoiaaiaoe/ii iaa?oioiaaia
noaia eiiieaenii? oa?ai?? ACO o ii?iae?eue ?c canoinoaaiiyi oieioa?ieo
aoeaoaoo, ia?i?aeeio oa i?aia?ao?a oeiona c ?o ?iaeea?aeoaeueiei
i?aeai?ii a oanoao ?n v?tro.

Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeai? a ee?i?/io
i?aeoeeo 11 aeooa?nueeeo oa a?iaeieia?/ieo a?aeae?eaiue Eoaainueea oa
iaeano?. Io?eiai? aeai? aeeth/ai? aei o/aiaiai i?ioeano eaoaae?
aeooa?noaa ? a?iaeieia?? oaeoeueoaoo i?neyaeeieiiiiai iaa/aiiy oa
e?eoaaeueiiai oaeoeueoaoo EAeIO.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeaii
caaaeueiiee?i?/ia oa aeooa?nueei-a?iaeieia?/ia ianoaaeaiiy 125
ii?iae?eue, oai?eo ia ACO ioa?ia??th, aeai? i?i yeeo iaaiaeyoueny o
aeena?oaoe??. Caeiaoaa/ i?eeiaa aaciina?aaeith o/anoue o cae?eniaii?
eiiieaenieo aeine?aeaeaiue ?ioiiiai noaoono ? a?io?i?/ieo iieaciee?a oa
ioe?ioe? i?e?iaaiiaeeiai?ee. Naiino?eii aeeiiai? ?ioiieia?/i? oanoe o 85
niinoa??aa?ieo iaoe??ioie, a?io?i?/i? aeine?aeaeaiiy – o 67 oa aea/aiiy
i?e?ioee?eoeyoe?? – o 54 ii?iae?eue. Niiooeoaa/ai aoa ?ic?iaeaiee ?
cai?iaaaeaeaiee a ee?i?/io i?aeoeeo can?a e?eoaaiiy ii?iae?eue c
i?neyiieiaiaith ?ioaeoe??th c aeeth/aiiyi aioeieneaeaioo,
aia?ii?ioaeoi?o oa ?ioiiiiaeoeyoi?a, i?iaaaeaia ioe?iea eiai
aoaeoeaiino? c o?aooaaiiyi aeeiai?ee a?io?i?/ieo oa ?ioiieia?/ieo
iieaciee?a ? noaio i?e?ioee?eoeyoe??. Naiino?eii aeeiiaia noaoenoe/ia
ia?iaea io?eiaieo ee?i?/ieo ? eaai?aoi?ieo aeaieo oa iieaciee?a
niaoe?aeueieo a?io?i?/ieo oa ?ioiieia?/ieo oano?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ? ?acoeueoaoe
aeaii? ?iaioe aeiiia?aeaeenue oa iaaiai?thaaeenue ia ?aa?iiaeuei?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeieia?y i?iieneiaiai ?aa?iio Aeiiaano”
(Eoaainuee, 1995), iaoeiai-i?aeoe/i?e eiioa?aioe?? “A?a??i?/i? i?iaeaie
ioi?iie caei?ia’y ianaeaiiy” (Aei?i?iiao?ianuee, 1997), I?aeia?iaei?e
eiioa?aioe?? “O?c?ieia?y oa iaoieia?y ?ioi?oaoo, aaiinoaco oa
ia?aeeniiai ieeneaiiy e?i?ae?a” (Iieoaaa, 1997), 1-io I?aeia?iaeiiio
iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1997),
ae?ci?e nan?? Oe?a?inueei? aeaaeai?? iaoe iaoe?iiaeueiiai i?ia?ano
(Oa?iii?eue, 1997).

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 148
noi??ieao iaoeiiieno oa aeeth/a? anooi, iaeyae e?oa?aoo?e, 5 ?icae?e?a
aeanieo aeine?aeaeaiue, ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy,
aeniiaee. Nienie aeei?enoaieo aeaea?ae neeaaea? 169 a?o/eciyieo oa 90
?iicaiieo e?oa?aoo?ieo iineeaiue. Iaoa??aee aeena?oaoe?? ?ethno?iaaii 20
oaaeeoeyie, 18 ?enoieaie ? 5 ee?i?/ieie niinoa?aaeaiiyie.

Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaai? a 20 iaoeiaeo
?iaioao, a oiio /ene? a 15 noaooyo (c ieo 9 iaeiiin?aieo) o oaoiaeo
aeaeaiiyo, caoaa?aeaeaieo AAE Oe?a?ie (7 a aeo?iaeao ? 8 o ca??ieeao
iaoeiaeo i?aoeue) oa 5 oacao aeiiia?aeae ia iaoeiaeo eiioa?aioe?yo ?
neiiic?oiao.

INIIAIEE CI?NO

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. I?ae iaaeyaeii ciaoiaeeeinue 125
ii?iae?eue c i?neyiieiaiaeie ai?eii-caiaeueieie caoai?thaaiiyie. A?e
ianoaaeaieo ae?iie aoa o iaaeao a?ae 16 aei 38 ?ie?a. An? niinoa??aa?i?
ii?iae?ee? aoee ?ic?iaeaeai? e??cue i?e?iaei? iieiaia? oeyoe.

C iaoith aecia/aiiy aoaeoeaiino? cai?iiiiiaaiiai eiiieaeno i?aia?ao?a
ii?iae?ee? c ACO ca aeiaaeeiaith iciaeith aoee ?iciiae?eai? ia aea?
a?oie, ye? aoee ni?anoaaeieie ca na?aaei?i a?eii, ia?eoaoii, oiiaaie
iaoeaiiy oa oyaee?noth ia?aa?ao I?. Iaoe??ioee iniiaii? a?oie (62 iniae,
49,6%) ii?yae c o?aaeeoe?eiith oa?ai??th i?ioyaii 10–12 aei?a io?eioaaee
ia?i?aeei, oieioa?ieo aoeaoao oa iaeei c i?aia?ao?a oeiona (oaeoea?i,
oeiae?i, oeiiaai, oeiiioei) i?ney eiai ?iaeea?aeoaeueiiai i?aeai?o a
oanoao ?n v?tro. AE?iee a?oie ni?anoaaeaiiy (63 iniae, 50,4%) io?eioaaee
e?eoaaiiy o?eueee ca ocae/a?iith noaiith.

sse ?aa?iiaeuei? ii?ie ?ioiieia?/ieo, iaoaaie?/ieo iieaciee?a oa noaio
i?e?iaaiiaeeiai?ee o ii?iae?eue aeei?enoiaoaaee aeai? i?aeeaoaae?aeueii?
eaai?aoi??? EAeIO, ui io?eiai? a ?acoeueoao? ianoaaeaiiy 50 caei?iaeo
ae?iie c o?c?ieia?/iei ia?aa?aii i?neyiieiaiaiai ia??iaeo.

An? iaoe??ioee i?aeeyaaee aeeiai?/iiio ianoaaeaiith, yea aeeth/aei o
naaa o?ceeaeueia oa aeooa?nueei-a?iaeieia?/ia ina?ae/aiiy,
caaaeueiii?eeiyo? eaai?aoi?i? aeine?aeaeaiiy, a oaeiae eiiieaen
niaoe?aeueieo a?io?i?/ieo, ?ioiieia?/ieo oano?a ? aea/aiiy noaio
i?e?ioee?eoeyoi?iiai ?onea (IOe?).

Aecia/aiiy ao?ieia?/iiai oaeoi?a i?neyiieiaiaeo caoai?thaaiue
cae?enithaaee caniaii na??eieo ?icaaaeaiue a?aeae?ey?iiai c ina?aaee?a
caiaeaiiy iaoa??aeo, c ianooiiei aen?aii ia aeaeoeai?, naeaeoeai? oa
aeeoa?aioe?eii-ae?aaiinoe/i? na?aaeiaeua. Aeine?aeaeaiiy /ooeeaino?
i?e?ii?aai?ci?a aei aioea?ioee?a i?iaiaeeee iaoiaeii aeeooc?? a aaa? ?c
canoinoaaiiyi noaiaea?oieo iaia?iaeo aeene?a oeyoii na??eieo
?icaaaeaiue. Ao?ieia?/ia ae?aaiinoeea i?iaiaeeeanue c o/anoth oa
iaoiaee/iith aeiiiiiaith ni?a?ia?oiee?a Oa?e?anueeiai IAe? i?e?ia?ieia??
? ?ioiieia?? ?i. ?.?. Ia/ieeiaa (aee?aeoi? – TH.E. Aieyinueeee).

Ai?no o ieaci? “na?aaei?o iieaeoe” (NI) ioe?ithaaee niaeo?ioioiiao?e/iei
iaoiaeii (A.A. I?eieae/ee oa ni?aaao., 1991). I?i ?ioaineai?noue
ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) noaeeee ca eiioeaio?aoe?yie a
ieaci? e?ia? iaeiiiaiai aeeaeueaeaa?aeo (IAeA) ? ae??iiaeo eii’thaao?a
(AeE) oa cia/aiiyi iieacieea ia?aeeniiai aaiie?co a?eo?ioeeo?a (IAA)
(A.I. Ei?iaaeieeiaa, 1989). Aeoeai?noue oa?iaio?a nenoaie
aioeieneaeaioiiai caoenoo (AIC) – eaoaeace (EO) oa noia?ieneaeaeeniooace
(NIAe) aecia/aee niaeo?ioioiiao?e/iei iaoiaeii (N. *aaa?? oa ni?aaao.,
1991). Aeey noaeaeaiiy i?i aca?iia?aeiioaiiy i?ae ci?iaie ?ioaineaiino?
IIE oa eiiiainaoi?ieie cae?aiinoyie AIC ia/enethaaee ?iaeaen O, yeee
aei??aith? aeiaooeo cia/aiue aeoeaiino? NIAe ? EO, iiae?eaiiio ia
eiioeaio?aoe?th IAeA (N. *aaa?? oa ni?aaao., 1991).

Noai i?e?iaaiioee?eoeyoe?? aea/aee caniaaie a?ii?e?ineii?? aoeueaa?ii?
eii’thieoeae (AAE) (c ioe?ieith ii?ooaiue ca aaeueiith nenoaiith
eii’thieoeaaeueieo ?iaeaen?a (E?)), eai?ey?ineii?? oa iooaeueiineii??
(N.A. Naeaciueia oa ni?aaao., 1985).

E?euee?nio ioe?ieo noaio ?ioi?oaoo i?iaiaeeee oeyoii i?ae?aooieo /enea
A, O-e?ioioeeo?a oa ?o iniiaieo ?aaoeyoi?ieo noaiiioeyoe?e a
oeeoioiene/iiio oano? c iiiieeiiaeueieie aioeo?eaie (IA) (A.I. O?ieia oa
ni?aaao, 1989). Aeei?enoiaoaaee eiia?oe?ei? IA o??ie “Ortho D?agnost?c
Systems Inc.” (USA) aeey ?aeaioeo?eaoe?? e?ioioeeo?a c oaiioeiii CD3+
(oioaeueia iiioeyoe?y Oee?oei), CD4+ (Ooaeia?e/?iaeoeoi?e), CD8+
(Onoi?ani?e/e?ea?e), CD22+ (Ae?ioioeeoe); ia/enethaaee ?ioii?aaoeyoi?iee
?iaeaen CD4/CD8. Ooieoe?iiaeueio aeoeai?noue e?ioioeeo?a aecia/aee a
?aaeoe?? aeanoo?ainoi?iaoe?? (?AOE), ye niiioaii?e, oae ? c
o?oiaaiaaethoei?iii (OAA). Nooi?iue nainea?e?caoe?? ?ioiioeeo?a aei
oeaiaaeo aooiaioeaai?a aea/aee a ?aaeoe?? aaeueioaaiiy i?a?aoe??
e?ioioeeo?a (?AIE) c e?iii?ioa?aeii ia/?iee (EIE), aioeaaiaie oeiona
(OA), aiaeiiao??th (AiA) oa i?iiao??th (IiA) (A.O. *a?iooaiei, 1988).

?c aoii?aeueieo iieaciee?a ?ioi?oaoo aecia/aee eiioeaio?aoe??
?ioiiaeiaoe?i?a (Ig) eean?a A, M, G o ne?iaaooe? e?ia? iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? (G. Mancini et al., 1965). Ai?no
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) oa ?o o?aeoe?eiee neeaae
aeine?aeaeoaaee iaoiaeii aeeoa?aioe?eii? i?aoeei?oaoe?? o 2%, 3,5% oa 6%
?ic/eiao iie?aoeeaiae?eieth (A.I. O?ieia oa ni?aaao., 1990). ??aaiue o
ieaci? I?O ioe?ithaaee ca cia/aiiyi ?iaeaeno ?ia?a?oe?? (??) ?aaeoe??
?ia?a?thaaiiy aeoeaiino? ne?iaaoeiaeo aioeo?e (??A) (I.A. AEo?aaeueiaa
oa ni?aaao., 1988).

Oaaioeeoa?io aeoeai?noue iiiioeeo?a (OAI) aea/aee /aoa/eiaei iaoiaeii
(A.I. O?ieia oa ni?aaao., 1990), i?e oeueiio ia/enethaaee oaaioeeoa?iee
?iaeaen (O?), oaaioeeoa?ia /enei (O*), ?iaeaen ao?aeoe?? (?A) oa ?iaeaen
ia?ao?aaethaaiiy (?I). Aeoeai?noue e?cioeeio o ne?iaaooe? e?ia? aea/aee
iaoaeiiao?e/iei iaoiaeii, ai?no eiiieaiaioo – aaiie?oe/iei iaoiaeii
oeo?oaaiiy ii 50% aaiie?co (A.N. Eicethe oa ni?aaao., 1987).

Eiiieaen aeuaaeacaieo aeine?aeaeaiue an?i ii?iae?eeyi c I? i?iaiaeeee
i?e iaaeoiaeaeaii? aei noaoe?iia?o ? /a?ac 14–16 ae?a a?ae ii/aoeo
e?eoaaiiy. I?aea?? i?aia?ao?a a oanoao ?n v?tro cae?enithaaee ca
aeiiiiiaith LAI-oanoo (E.O.*a?iooaiei, 1995).

Noaoenoe/iee aiae?c iaea?aeaieo aeaieo aeeiioaaee ia IAII eeano Pentium
?c canoinoaaiiyi i?eeeaaeieo i?ia?ai, ?ic?aoiaaieo ia ia?iaeo
iaaeeei-a?ieia?/ii? ?ioi?iaoe??. Aeey eiaeii? aea??ee ia/enethaaee
na?aaeith a?eoiaoe/io (M) oa iiieeeo ?ai?acaioaoeaiino? (m).
Aeinoia??i?noue ??cieoe? aea??eiaeo na?aaei?o aaee/ei aecia/aee ca
e?eoa???i No’thaeaioa (t). Nooi?iue aca?iica’yceo i?ae e?euee?nieie
iciaeaie aea/aee oeyoii ei?aeyoe?eiiai aiae?co c aecia/aiiyi
eiao?oe??io?a ei?aeyoe?? (r).

Ee?i?/ia oa?aeoa?enoeea ai?eiicaiaeueiex caoai?thaaiue o ianoaaeaieo
ii?iae?eue. Na?aae ianoaaeaieo iaie ii?iae?eue o 73 in?a (58,4%) aoee
anoaiiaeai? oi?ie I?, ui a?aeiia?aeathoue ? aoaio ?iciianthaeaeaiiy
iaoieia?/iiai i?ioeano, a naia aiaeiiao?eoe, i?neyiieiaia? ae?acee (1
a?oia), o 52 in?a (41,6%) – ?? aoaio, oae?, ye iao?eoe, aaeiaeneoe,
o?iiaioeaa?o iaoeiaeo aai, iaeuea?iia?eoii?oe (2 a?oia).

O ee?i?/i?e ea?oei? i?neyiieiaiaeo ACO ia?aaaaeia i?noea caeiaee
neiae?ii ?ioieneeaoe?? oa i?noeaa? i?iyaeaiiy caiaeaiiy. Neiae?ii
?ioieneeaoe?? i?e eaaeiio oa na?aaeiueioyaeeiio ia?aa?ao I?
oa?aeoa?ecoaaany iacaeoaeaiiyi, i?iianieoeath, inooaeith,
a?ia?a?ae?icii, aii?aen??th; a a?eueo oyaeeeo aeiaaeeao niinoa??aaee
oao?ea?ae?th, cieaeaiiy a?oa??aeueiiai oeneo, oeaoaea?th, aeenniii?th,
aeenoi??th. C i?noeaaeo iciae caiaeueiiai i?ioeano i?e aiaeiiao?eo? iaee
i?noea aeae?eaiiy ?c noaoaaeo oeyo?a, oiia?eueiaiiy ?iaiethoe?? iaoee,
i?e iao?eo? – a?aee?eoee iaoeiaee c?a, a?eue aieco aeeaioa oa
aie?ni?noue iaoee i?e iaeueiaoe??, i?e iaeuea?iia?eoii?o? a?aei?/aee
neiioiie iiae?aciaiiy i/a?aaeie.

Na?aae oai?eo ii?iae?eue o 110 in?a ?a?no?oaaee aiai?th. I?e oeueiio o
iaoe??ioie 2 a?oie ai?no a?eo?ioeeo?a aoa ieae/ei ia 9,1%, i?ae o
ae?iie 1 a?oie (p<0,05) ? ia 15,2% iaioa, i?ae o caei?iaeo ii?iae?eue (p<0,01). Ai?no eaeeioeeo?a i?aeaeuoaaany a 1,42 oa 2,21 ?ace (a?aeiia?aeii i?e ? oa ?? aoaiao aaia?ae?caoe??) a?ae cia/aiiy o caei?iaeo ii?iae?eue. I??a ci?i ?aooe eaai?aoi?ieo iieaciee?a iaea aiaeia?/io aeeiai?eo – c?inoaea i?e ca?eueoaii? nooiaiy aaia?ae?caoe?? I?. I?e ei?aeyoe?eiiio aiae?c? aoea oaeiae anoaiiaeaia cai?ioia caeaaei?noue ae?aaeaiino? ci?i ee?i?ei-eaai?aoi?ieo iieaciee?a a?ae aaee/eie e?iaiao?aoe o iieiaao oa o?eaaeino? aacaiaeiiai ia??iaeo. Aeai? ao?ieia?/ii? ae?aaiinoeee aeicaieeee eiinoaooaaoe ia?aaaaeia cia/aiiy i?eno-?ioaeoe?? (60,8% niinoa?aaeaiue) o aeieeiaii? ai?eiicaiaeueieo caoai?thaaiue ioa?ia??th. Na?aae iie?i?e?iaieo anioe?aoe?e aeii?ioaaee niieo/aiiy i?iaaiii? i?e?ioei?e c a?aiiaaaoeaieie aaoeeeaie oa oiiaii iaoiaaiieie i?e?ii?aai?ciaie. Aiaa?iaia oei?a oaeiae ?a?no?oaaeanue o ii?aeiaii? ?c aa?iaaie ??cieo aeae?a (9,6%). Na?aae aeiaaee?a iiii?ioaeoe?? i?iaaiia oa oiiaii iaoiaaiia oei?a cono??/aeenue c i?eaeecii iaeiaeiaith /anoioith. Iaoaaie?/i? oa i?e?iaaiiaeeiai?/i? ii?ooaiiy o ii?iae?eue c ai?eiicaiaeueieie oneeaaeiaiiyie. O an?o niinoa??aa?ieo ii?iae?eue ?a?no?oaaee ?icaeoie neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??, i?iyaeaiiyi /iai neoaeeei, cie?aia, i?aeaeuaiiy ai?noo ?a/iaei na?aaeiuei? iieaeoey?ii? iane. Ae?aaeai?noue neiae?iio iaoaaie?/ii? ?ioieneeaoe?? a iaai?e i??? ei?aethaaea c oyaee?noth ia?aa?ao ?ioaeoe?eiiai i?ioeano. Oae o ii?iae?eue c ? aoaiii iioe?aiiy I? ??aaiue NI aeinyaaa 1,07±0,02 a/e (i?e ii?i? 0,62±0,01 a/e), i?e ?? aoai? – 1,37±0,04 a/e. Anoaiiaeaii, ui ee?i?/ia iai?oanoaoe?y I? a?aeaoaa?oueny ia oe? i?aeaeuaii? ?ioaineaiino? i?ioean?a ia?ieneaeaoe?? e?i?ae?a. Oae o ii?iae?eue 1 a?oie eiioeaio?aoe?y a ne?iaaooe? e?ia? IAeA c?inoaea a na?aaeiueiio a 2,14 ?ace, a AeE – a o 1,47 ?ace o ii??aiyii? ?c ii?iith. Na?aae iaoe??ioie 2 a?oie ai?no oeeo niieoe c?inoaa a?aeiia?aeii a 3,02 1,92 ?ace. Aiaeia?/io aeeiai?eo iaa iieaciee IAA, eio?ee i?e oyaeeeo oi?iao I? aei??aithaaa 11-14%. I?e ?iaeea?aeoaeueiiio aiae?c? cia/aiiy aeoeaiino? NIAe aoee anoaiiaeai? ci?ie aeaiiai iieacieea ye o a?e ca?eueoaiiy, oae ? o a?e ciaioaiiy. Oea, ia iaoo aeoieo, aoei iia’ycaia c ??ciei nooiaiai eiiiainaoi?ii-i?enoinoaaeueieo iiaeeeainoae aeaiiai oa?iaioo. Aeoeai?noue EO aoea cieaeaiith o an?o iaoe??ioie c I?, ine?eueee oeae oa?iaio aieiae?? iaioeie eiiiainaoi?ieie aeanoeainoyie. Cia/aiiy iieacieea eaoaeacii? aeoeaiino? na?aae ii?iae?eue 1 a?oie aoei ieae/a ii?ie a na?aaeiueiio a 1,22 ?ace, a 2 a?oi? – a 1,46 ?ace. O an?o oai?eo ia I? ii?iae?eue anoaiiaeai? ii?ooaiiy c aieo IOe?, ye? aoee i?i?iaeuei? na?aae iaoe??ioie c eaaeei ia?aa?aii caoai?thaaiiy (niaci a?oa??ie, oiia?eueiaiiy e?iaiieeio, cieaeaiiy e?eueeino? ooieoe?iioth/eo eai?ey??a, neaaeae-neiae?ii ? no.) ? iaeneiaeuei? i?e oyaeeiio (aeeeyoaoe?? oa caeaeno?noue aaioe, ooai?aiiy aaaneoey?ieo cii, i?e?iaiaa?ecie oa naeoeyoe?? aaioe ? eai?ey??a, neaaeae-neiae?ii ????V no., ia?eaaneoey?iee iaa?ye, i?e?iaaii?aa??). Aiaeia?/i? ci?ie niinoa??aaeenue ? i?e iooaeueiineii??. I?e eai?ey?ineii?? ?a?no?oaaee ciaioaiiy e?eueeino? aeaeeieo eai?ey??a, ?icoe?aiiy aaiicii? a?aio? oa caoaeaiiy a?oa??aeueii?, iineeaiiy iooiino? oiio, i?e/iio oe? ii?ooaiiy aoee iaea?eueo ae?aaeaieie o ii?iae?eue c oyaeeeie oi?iaie I?. Noiae?noue ?iceaae?a o IOe?, ye? aeyaeyeenue ??cieie iaoiaeaie, aeaco? ia aaia?ae?ciaaiee oa?aeoa? ci?i i?e?iaaiiaeeiai?ee i?e i?neyiieiaiaeo ACO. I?e e?euee?ni?e ioe?ioe? noaio i?e?iaaiiaeeiai?ee anoaiiaeaii c?inoaiiy E?caa aei 10,2±0,11 aae?a na?aae ii?iae?eue 1 a?oie (i?e ii?i? 5,8±0,14), ? aei 12,4±0,16 aae?a o ae?iie 2 a?oie. Aeeaeia i?e?iaaiiaeeiai?/ieo ii?ooaiue ? nooi?iue ae?aaeaiino? NI? ciaoiaeeeenue a i?yi?e ei?aeyoe?ei?e aca?iicaeaaeiino?. Noai ?ioi?oaoo oa nenoaie i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino? i?e naioe/ieo oneeaaeiaiiyo ioa?ia??th. O an?o iaoe??ioie c I? a?aecia/aeanue O-e?ioiiai?y. Oae ai?no CD3+ee?oei o ae?iie 1 a?oie aoa ieae/ei o 1,31 ?ace, i?ae o caei?iaeo ii?iae?eue, o 2 a?oi? – a 1,52 ?ace. E?euee?noue CD4+e?ioioeeo?a cieaeoaaeanue na?aae ii?iae?eue c ? aoaiii iioe?aiiy I? aei 25,7±0,33%, na?aae iaoe??ioie c 2 aoaiii – aei 22,4±0,35%. Ai?no CD8+e?ioioeeo?a ?noioii ia a?ae??ciyany a?ae aiaeia?/iiai iieacieea o caei?iaeo ii?iae?eue. A?aeaeca?eaeaiiyi oaeeo ci?i noaiiioeyoe?eiiai neeaaeo Oe?ioioeeo?a aoei cieaeaiiy cia/aiiy ?ioii?aaoeyoi?iiai ?iaeaeno CD4/CD8 a 1,37 ?ace a?ae ii?ie o iaoe??ioie ? a?oie oa a 1,74 ?ace o ii?iae?eue 2 a?oie. Aeuaaeacai? aeai? na?ae/eee i?i oi?ioaaiiy o ii?iae?eue c ACO aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? ia?aaaaeii ca a?aeiiniei noi?ani?iei aa??aioii. Iieaciee niiioaiii? ?AOE o iaoe??ioie c ? aoaiii iioe?aiiy ?ioaeoe?? cieaeaany a 1,35 ?ace ii a?aeiioaiith aei ii?ie, i?e ?? aoai? – a 1,63 ?ace; a ?acoeueoaoe ?aaeoe?? c OAA a?aeiia?aeii ciaiooaaeenue a 1,27 oa 1,45 ?ace. Oea na?ae/eoue i?i cia/ia iaiaaeaiiy ooieoe?iiaeueieo cae?aiinoae ?ioiioeeo?a i?e iinoaii? i?neyiieiaiaeo ACO. I?e i?iaaaeaii? ?AIE c OA ? EI* a?aei?/aee ciaioaiiy i?a?aoe?eiiai ?iaeaeno (I?) a?aeiia?aeii ia 20,4% e 17,3% o ii?iae?eue 1 a?oie, ia 29,6% ? 24,5% o iaoe??ioie 2 a?oie. I? c AiA oaeiae ciaiooaaany i?e iineeaii? oyaeeino? ia?aa?ao I?. I? c IiA na?aae ae?iie c i?neyiieiaiaei aiaeiiao?eoii aeinoia??ii ia a?ae??ciyany a?ae ii?iaeueiiai cia/aiiy, a oie /an, ye o iaoe??ioie c a?eueo aaia?ae?ciaaieie oi?iaie – i?e ?iciianthaeaeaii? caiaeueiiai i?ioeano ia i’yciaee oa? – aoa iaioa 0,75 i?e ii?i? 0,98±0,01. Aeai? ?AIE aeacothoue ia ?noioia cia/aiiy aooi?ioiiiai eiiiiiaioo a ?icaeoeo ACO ioa?ia??th. O iaoe??ioie c I? iaea i?noea aeen- oa a?ii?ioiiaeiaoe?iai?y. I?e ?iaeea?aeoaeueiiio aiae?c? aoei anoaiiaeaii, ui ci?ie ai?noo Ig A o ianoaaeaieo ae?iie aoee ??ciini?yiiaaieie. Oae o ii?iae?eue c eaaeei ia?aa?aii I? ia?aaaaeii iaei i?noea ca?eueoaiiy ai?noo ? iaaiaee. Eiioeaio?aoe?y Ig M o oai?eo ii?iae?eue iaea /?oeo oaiaeaioe?th aei cieaeaiiy i?e c?inoaii? nooiaiy aaia?ae?caoe?? ?ioaeoe?? ? ciaiooaaeanue a 1,34, 1,53 ?ace a?aeiia?aeii a 1 ? 2 a?oiao. Aiaeia?/ii o niinoa??aa?ieo iaoe??ioie ci?ithaaany ? ??aaiue Ig G, niaaeath/e o oyaeeeo aeiaaeeao ieae/a 9 a/e i?e ii?i? aeey ii?iae?eue 17,2±0,19 a/e. O iaoe??ioie c I? niinoa??aaee c?inoaiiy ??aiy Oe?E a ne?iaaooe? e?ia?: na?aae oai?eo c ? aoaiii aaia?ae?caoe?? – a 1,73 ?ace ii a?aeiioaiith aei ii?ie, o ae?iie c ?? aoaiii – a 2,39 ?ace. Ca?eueoaiiy eiioeaio?aoe?? Oe?E o ianoaaeaieo ii?iae?eue a?aeaoaaeinue ia?aaaaeii ca ?aooiie iaea?eueo iaoiaaiieo ae??aii- oa na?aaeiueiiieaeoey?ieo o?aeoe?e, noia?iee ai?no yeeo i?aeaeuoaaany a?aeiia?aeii a 2,96 oa 2,01 ?ace, i?ae o ae?iie c o?c?ieia?/iei ioa?ia???i. Aeai? o?aeoe?? caeaoi? a?aeeeaaeaoenue o ?ioei? noaeei, ui i?ecaiaeeoue aei i?ia?anoaaiiy ii?ooaiue i?e?iaaiiaeeiai?ee. O an?o ii?iae?eue c ACO aoei aeyaeaii cieaeaiiy OAI. Oae, cia/aiiy O? o iaoe??ioie 1 a?oie ciaiooaaeinue a na?aaeiueiio a 1,36 ?ace a?aeiinii ii?iaoeaiiai cia/aiiy, a ae?iie 2 a?oie – a 1,56 ?ace. Aiaeia?/ia oaiaeaioe?y niinoa??aaeanue ? c aieo O* oa ?A. Iaea?eueoiai i?eai?/aiiy caciaaaea oaca ia?ao?aaeaiiy, i?i ui na?ae/eei iaae?iiy cia/aiiy ?I na?aae iaoe??ioie c ? aoaiii aaia?ae?caoe?? ?ioaeoe?? 1,47 ?ace, a c ae?oaei aoaiii – a 1,66 ?ace. Ai?no e?cioeeio o ne?iaaooe? e?ia? oai?eo ii?iae?eue ciaiooaaany a?aeiia?aeii aei 8,17±0,07 a/e oa 7,21±0,08 a/e, a oeo? eiiieaiaioo – a 2,65, 3,66 ?ace. O ianoaaeaieo iaoe??ioie c ACO ioa?ia??th c?inoaee ?ia?a?oe?ei? ni?iiiaeiino? ne?iaaoee e?ia?. Oae na?aaei? cia/aiiy ?? ??A i?e ? aoai? aaia?ae?caoe?? i?aeaeuoaaeinue aei 2,05±0,03 (i?e ii?i? aeey ii?iae?eue 1,14±0,03), i?e ?? aoai? – aei 2,98±0,09. I?e iaoaiaoe/iiio aiae?c? aoee anoaiiaeai? ei?aeyoeai? caeaaeiino? ai?noo O-e?ioioeeo?a a?ae ??aiy IAeA (r= -0,628), cia/aiiy O (r=+0,539) oa ai?noo NI (r=-0,774), ?iaeaeno CD4/CD8 a?ae aeoeaiino? eaoaeace (r=+0,524), eiioeaio?aoe?? NI (r=-0,738), cia/aiiy ?I a?ae eiioeaio?aoe?? AeE (r=-0,436), ??aiy NI (r=-0,624). Oea aeaco? ia iaaio iaoiaaiaoe/io ?ieue NI? o ?icaeoeo ?ioiieia?/ieo ?iceaae?a i?e I?. Aeyaeai? neeuei? oa na?aaei? cai?ioi? ei?aeyoeai? ca’ycee i?ae ?? ??A ? oaeeie iieacieeaie, ye e?euee?noue CD3 ? CD4 ee?oei, cia/aiiy ?AOE, O? oa ?I, ai?no Ig M oa Ig G na?ae/aoue i?i ?noioiee aieea I?O ia noai ?ioiieia?/ii? ?aaeoeaiino? i?aai?cio oai?eo ia I? ii?iae?eue. Aoaeoeai?noue cai?iiiiiaaiiai eiiieaeno i?aia?ao?a i?e e?eoaaii? i?neyiieiaiai? ?ioaeoe??. Aeey ioe?iee aoaeoeaiino? cai?iiiiiaaiiai eiiieaeno i?aia?ao?a ii?iae?ee? c ACO ca aeiaaeeiaith iciaeith aoee ?iciiae?eai? ia aea? ?aiaeii?ciaai? a?oie. Iaoe??ioee iniiaii? a?oie (62 iniae, 49,6%) ?acii ?c caaaeueiii?eeiyoith oa?ai??th i?ioyaii 12–16 aei?a io?eioaaee ia?i?aeei, oieioa?ieo aoeaoao oa iaeei c i?aia?ao?a oeiona (oaeoea?i, oeiae?i, oeiiaai, oeiiioei) i?ney eiai ?iaeea?aeoaeueiiai i?aeai?o a oanoao ?n v?tro. AE?iee a?oie ni?anoaaeaiiy (63 iniae, 50,4%) iaea?aeoaaee o?eueee o?aaeeoe?eia e?eoaaiiy. Ca ?acoeueoaoaie ?iaeea?aeoaeueiiai i?aeai?o i?aia?ao?a oeiona a oanoao in vitro 21 ii?iae?ee? iniiaii? a?oie (33,9%) aoa i?ecia/aiee oaeoea?i, 17 (27,4%) – oeiiaai, 13 (21,0%) – oeiae?i, 11 (17,7%) – oeiiioei. A ee?i?/iiio ieai? o iaoe??ioie iniiaii? a?oie niinoa??aaee iaioo o?eaae?noue neiioii?a caaaeueii?ioieneeaoe?eiiai neiae?iio ? i?noeaaeo iciae caiaeaiiy. I?iianiee ia??iae o ae?iie iniiaii? a?oie aoa ei?iooa, i?ae o iaoe??ioie a?oie ni?anoaaeaiiy a na?aaeiueiio ia 2,45±0,24 aeiae, oao?ea?ae?y cieeaea ?ai?oa ia 1,99±0,20 aeiy, a?iioii?y – ia 1,84±0,16 aeiy, a?ia?a?ae?ic – ia 2,64±0,27 aeiy. A iniiai?e a?oi? oaeaeoa e?ea?aeoaaeenue ii?ooaiiy nio (ia 3,49±0,29 aeiae), ?iceaaee iano?ith (ia 4,31±0,29 aeiae), a?aeiiaethaaany aiaoeo (ia 3,69±0,25 aeiae). I?ae aieeaii cai?iiiiiaaiiai eiiieaeno i?aia?ao?a ?ai?oa cieeaei ?ici’yeoaiiy iaoee (ia 3,57±0,28 aeiy) oa a?aeaoaaeanue ii?iae?caoe?y i?ioean?a ?iaiethoe?? iaoee (ia 3,33±0,25 aeiy). O?eaae?noue aieth o iaoe??ioie iniiaii? a?oie aoea ia 2,69±0,24 aeiae iaioith, i?ae o ae?iie a?oie ni?anoaaeaiiy, oa?aeoa? aeae?eaiue ?c noaoaaeo oeyo?a ii?iae?coaaany ia 2,56±0,24 aeiy ?ai?oa. A?aeaeca?eaeaiiyi iiceoeaiiai aieeao ia ee?i?/iee ia?aa?a I? oieioa?ieo aoeaoaoo, ia?i?aeeio e i?aia?ao?a oeiona aoei nei?i/aiiy no?ie?a aini?oae?caoe?? iaoe??ioie iniiaii? a?oie – a na?aaeiueiio ia 5,43±1,17 aeiae iaioa, i?ae o ii?iae?eue a?oie ni?anoaaeaiiy. O ii?iae?eue, ye? i?e e?eoaaii? iaea?aeoaaee cai?iiiiiaaiee eiiieaen i?aia?ao?a, oaeaeoa, i?ae o ae?iie a?oie ni?anoaaeaiiy, a?aeiiaethaaeenue iieacieee aaiia?aie, i?ioa?iia?aie ? eiaaoeia?aie. Iiceoeaiee aieea ia ee?i?/iee ia?aa?a ACO cai?iiiiiaaiee eiiieaen i?aia?ao?a /eiea, ia iaoo aeoieo, ca ?aooiie aaeaeaaoiai eoi??oaaiiy iaoaaie?/ieo ?iceaae?a ? a?aeiiaeaiiy i?e?iaaiiaeeiai?ee oa ?ioiiiai noaoono. Oae, na?aaei? cia/aiiy ai?noo NI o iaoe??ioie, ye? io?eioaaee cai?iiiiiaaiee eiiieaen i?aia?ao?a, cieaeoaaeinue ia 39,3% a?ae ii/aoeiaeo aeaieo ? ciaoiaeeeinue ia aa?oi?e iaae? ii?ie. O ii?iae?eue a?oie ni?anoaaeaiiy oaiaeaioe?y aei ii?iae?caoe?? ai?noo NI aoea a?aenooiy – ??aaiue aeaieo niieoe caeeoaany aeua ii?ie a 1,75 ?ace. Eiioeaio?aoe?y IAeA o ae?iie iniiaii? a?oie i?ney e?eoaaiiy cieaeoaaeanue a 1,63 ?ace a?ae ii/aoeiaiai cia/aiiy ? aoea eeoa iacia/ii a?eueoa ii?iaeueiiai iieacieea. A oie aea /an o ii?iae?eue a?oie ni?anoaaeaiiy i?ney cae?i/aiiy o?aaeeoe?eii? oa?ai?? I? ??aaiue IAeA ia iaa ?noioieo ci?i. Ai?no AeE o iaoe??ioie iniiaii? a?oie iai?ee?ioe? e?eoaaiiy aeinoia??ii ia a?ae??ciyany a?ae aiaeia?/iiai iieacieea o caei?iaeo ii?iae?eue. Caaaeueiii?eeiyoa noaia oa?ai?? ACO ioa?ia??th a aeaye?e i??? oaeiae ni?eyea ciaioaiith ??aiy AeE, i?ioa, cia/aiiy aeaiiai iieacieea ni?anoaaeaiiy ia?aaeuoaaei ii?io a 1,48. Aeei?enoaiiy cai?iiiiiaaiiai eiiieaeno ni?eyei noaa?e?caoe?? ee?oeiieo iaia?ai, ui i?aeoaa?aeaeoaaeinue cieaeaiiyi iieacieea IAA na?aae iaoe??ioie iniiaii? a?oie ia 36,6% a?ae aeo?aeiiai cia/aiiy. O iaoe??ioie, ui io?eioaaee i?aia?aoe c aia?ii?ioaeoi?ieie, aioeieneaeaioieie oa ?ioiio?iiieie aeanoeainoyie, i?ney caaa?oaiiy e?eoaaiiy cia/aiiy aeoeaiino? NIAe aeinoia??ii ia a?ae??ciyeinue a?ae aiaeia?/iiai iieacieea o ii?iae?eue c o?c?ieia?/iei ioa?ia???i. Na?aae iaoe??ioie a?oie ni?anoaaeaiiy cia/aiiy aeoeaiino? NIAe i?e aeienoe? aoei a 1,32 ?ace ieae/a ii?ie. A iniiai?e a?oi? aeoeai?noue EO o ae?iie c eaaeei oa na?aaeiueioyaeeei ia?aa?aii ACO aeinyaaea ieaeiuei? iaae? ii?ie, a i?e oyaeeiio ia?aa?ao – iaea /?oei ae?aaeaio oaiaeaioe?th aei ii?iae?caoe??. A a?oi? ni?anoaaeaiiy i?e aeienoe? eaoaeacia aeoeai?noue caa??aaeanue ieae/a ii?ie a 1,22 ?ace. Cia/aiiy ?ioaa?aeueiiai ?iaeaeno O i?ney canoinoaaiiy cai?iiiiiaaiiai eiiieaeno iaei /?oei ae?aaeaio oaiaeaioe?th aei ii?iae?caoe??, a oie aea /an o iaoe??ioie a?oie ni?anoaaeaiiy ?a?no?oaaee iiaeaeueoa cieaeaiiy ?iaeaeno O ia 15,6% a?ae ii/aoeiaiai cia/aiiy. I?e aeeth/aii? aei eiiieaenii? oa?ai?? I? ia?i?aeeio, a?oai?io A oa i?aia?ao?a oeiona a?aecia/aee i?aeaeuaiiy e?eueeino? ooieoe?iioth/eo eai?ey??a, cieeiaiiy caeaenoino? i?e?inoaeei oa ia??aiii??iino? ?o eae?a?o, a?aeiiaeaiiy o?c?ieia?/iiai ni?aa?aeiioaiiy ae?aiao??a a?oa??ie ? aaioe, cieeiaiiy aiioeiiiae?aieo ?icoe?aiue ? e?ea?aeaoe?th cii ?oai??. O ii?iae?eue iniiaii? a?oie ?a?no?oaaee iineeaiiy oaeaeeino? e?iaiieeio, cieeiaiiy aioo??oiueinoaeeiii? aa?aaaoe??, ?icniieooaaiiy ia?eaaneoey?iiai iaa?yeo ? i?e?iaaii?aa?e. Na?aae ii?iae?eue a?oie ni?anoaaeaiiy i?ney caaa?oaiiy o?aaeeoe?eiiai e?eoaaiiy oaiaeaioe?? aei ii?iae?caoe?? iieaciee?a i?e?iaaiiia?ooc?? ia niinoa??aaee. A iniiai?e a?oi? na?aaei? cia/aiiy E? ia iaee aeinoia??ii? ??cieoe? c aiaeia?/ieie iieacieeaie o caei?iaeo ii?iae?eue. O ae?iie a?oie ni?anoaaeaiiy E? aeinoia??ii ia a?ae??ciyeenue a?ae ii/aoeiaeo. Oaeei /eiii, aeei?enoaiiy eiiieaeno i?aia?ao?a c aioeieneaeaioieie, aia?ii?ioaeoi?ieie oa ?ioiiei?eaoth/eie aeanoeainoyie i?e e?eoaaii? ACO i?neyiieiaiaiai ia??iaeo ni?eyei ciaioaiith ae?aaeaiino? neiae?iio “iaoaaie?/ii?” ?ioieneeaoe?? oa a?aeiiaeaiith i?e?iaaiiaeeiai?ee. A i?e e?eoaaii? eeoa o?aaeeoe?eieie caniaaie, ia caaaeath/e ia ee?i?/ia iaeoaeaiiy, o iaoe??ioie caeeoaany ae?aaeaiee NI? oa aaia?ae?ciaaiee aia?iniaci. I?e aeiaeaoeiaiio aeei?enoaii? ia?i?aeeio, a?oai?io A oa ?ioiiei?aeoi??a i?e e?eoaaii? ii?iae?eue c ACO ie niinoa??aaee ciaioaiiy cia/aiiy ?? ??A aei 1,33±0,04, ui aoei ia aa?oi?e iaae? ii?ie. Oea na?ae/eoue, ui cai?iiiiiaaiee eiiieaen i?aia?ao?a aaaea aei cieaeaiiy ai?noo I?O o e?ia?. A a?oi? ni?anoaaeaiiy ?? ??A oaea?/? ia?aaeuoaaa aiaeia?/iee iieaciee o caei?iaeo ii?iae?eue, a i?e ii??aiyii? c aeo?aeieie aeaieie aeyaeyeinue iiaeaeueoa iineeaiiy ?ia?a?oe?eieo ni?iiiaeiinoae ne?iaaoee. A iniiai?e a?oi? ii?iae?eue i?ney caaa?oaiiy e?eoaaiiy a?aeiiniee ??aaiue CD3+ee?oei iaa /?oei ae?aaeaio oaiaeaioe?th aei ii?iae?caoe?? ? c?inoaa a 1,27 ?ace ii a?aeiioaiith aei ii/aoeiaiai cia/aiiy. O ae?iie, ui io?eioaaee o?eueee caaaeueiii?eeiyoa e?eoaaiiy, e?euee?noue Oe?ioioeeo?a caeeoaeanue cieaeaiith a 1,84 ?ace a?aeiinii ii?ie. Iaoe??ioee, ye? io?eioaaee ia?i?aeei, a?oai?i A ? i?aia?ao oeiona e?euee?noue CD4+e?ioioeeo?a c?inoaea aei ii?iaeueiiai cia/aiiy, ui na?ae/eei i?i a?aeiiaeaiiy oaeia?ii? aeoeaiino?. A?aeaeca?eaeaiiyi oeeo iiceoeaieo ci?i aoea ii?iae?caoe?y ?ioii?aaoeyoi?iiai eiao?oe??ioa CD4/CD8. O ii?iae?eue a?oie ni?anoaaeaiiy e?euee?noue Ooaeia??a/?iaeoeoi??a i?e aeienoe? aoea ieae/a ii?ie a 1,41 ?ace, a ?iaeaen CD4/CD8 – a 1,37 ?ace. O ii?iae?eue, ye? aeiaeaoeiai io?eioaaee ia?i?aeei, a?oai?i A oa ?ioiiei?eaoth/? i?aia?aoe, iieaciee niiioaiii? ?AOE aeinyaaa ii?iaeueiiai cia/aiiy o an?o iaoe??ioie c eaaeei ia?aa?aii I? oa o a?eueoino? c na?aaeiueioyaeeei e oyaeeei ia?aa?aii. Na?aaei? a?eoiaoe/ia iieacieea ?AOE c OAA iaaeeaeaeinue aei ieaeiuei? iaae? ii?ie. I?ney cae?i/aiiy o?aaeeoe?eiiai e?eoaaiiy ACO iieacieee ?AOE o niinoa??aa?ieo ae?iie iacia/ii i?aeaeuoaaeenue, aea a aeiaeii? ae?iee ia iaaeeaeaeenue aei iaae ii?ie. Oea na?ae/eei i?i iiceoeaiee aieea cai?iiiiiaaiiai eiiieaeno ooieoe?iiaeueieo ni?iiiaeiinoae Oe?ioioeeo?a. I?e i?iaaaeaii? ?AIE o iaoe??ioie, ye? io?eioaaee cai?iiiiiaaiee eiiieaen i?aia?ao?a, ?a?no?oaaee /?oeo oaiaeaioe?th aei ii?iae?caoe?? cia/aiue I?, ui aeacoaaei ia ciaioaiiy nainea?e?caoe?? e?ioioeeo?a aei aooiaioeaai?a. O ii?iae?eue, ui io?eioaaee eeoa ocaaaeueiaia e?eoaaiiy, cia/aiiy I? ia iaee ?noioii? iiceoeaii? aeeiai?ee, a a iaeeie/ieo aeiaaeeao aoee iaioeie, i?ae ii/aoeia?. O iaoe??ioie, ye? aeiaeaoeiai iaea?aeoaaee cai?iiiiiaaiee eiiieaen i?aia?ao?a, na?aaei? cia/aiiy ai?noo a ne?iaaooe? e?ia? Ig A ciaoiaeeeinue a ?aieao i?eionoeieo a?aeoeeaiue ii?ie, a ??aaiue Ig M iaaeeaeaany aei ieaeiuei? iaae?. O ae?iie iniiaii? a?oie i?ney cae?i/aiiy e?eoaaiiy eiioeaio?aoe?y Ig G iaea /?oei ae?aaeaio oaiaeaioe?th aei ii?iae?caoe??. O ii?iae?eue a?oie ni?anoaaeaiiy iaa?oue i?e e?ea?aeaoe?? ee?i?/ieo i?iyaeaiue I? caa??aaeanue a?ii- ? aeen?ioiiaeiaoe?iai?y. Aeeth/aiiy aei oa?ai?? ACO ioa?ia??th cai?iiiiiaaiiai eiiieaeno ni?eyei i?enei?aiith ae?i?iaoe?? c e?ia’yiiai ?onea Oe?E, i?i ui na?ae/eei cieaeaiiy o ae?iie iniiaii? a?oie i?ney e?eoaaiiy ai?noo oeeo niieoe aei aa?oiuei? iaae? ii?iaeueiiai cia/aiiy, a oie aea /an o iaoe??ioie a?oie ni?anoaaeaiiy ??aaiue Oe?E caeeoaany a 1,78 ?ace aeua ii?ie. A iniiai?e a?oi? niinoa??aaee oaeiae a?eueo oaeaeea a?aeiiaeaiiy o?aeoe?eiiai neeaaeo Oe?E, i?i ui na?ae/eea /?oea oaiaeaioe?y aei ii?iae?caoe?? ai?noo na?aaeiuei oa ae??aiiiieaeoey?ieo ?ioiieo eiiieaen?a. O ii?iae?eue a?oie ni?anoaaeaiiy i?ney caaa?oaiiy e?eoaaiiy ai?no oeeo o?aeoe?e cia/ii ia?aaeuoaaa ii?iaoeai? cia/aiiy. C iaaaaeaieo aeaieo aeoiaeeoue, ui aeei?enoaiiy cai?iiiiiaaiiai eiiieaeno i?aia?ao?a ni?eyei aaeueioaaiith ?ioiieiiieaenieo ?aaeoe?e. O niinoa??aa?ieo iaoe??ioie c I?, ye? iaea?aeoaaee oieioa?ieo aoeaoao, ia?i?aeei ? i?aia?ao oeiona, i?ney caaa?oaiiy e?eoaaiiy ca?a?no?iaaii i?aeaeuaiiy oaaioeeoa?ii? aeoeaiino? iiiioeeo?a, ui aeieoiaiooaaeinue c?inoaiiyi cia/aiue O? oa O* aei ieaei?o iaae ii?ie, c aieo ?A ? ?I ?a?no?oaaeanue /?oei ae?aaeaia oaiaeaioe?y aei ii?iae?caoe??. O iaoe??ioie a?oie ni?anoaaeaiiy c aieo iieaciee?a OAI a?aecia/aeanue eeoa neaaea iiceoeaia aeeiai?ea. Na?aaei? cia/aiiy ai?noo e?cioeeio o iaoe??ioie iniiaii? a?oie i?ney e?eoaaiiy i?aeaeuoaaeinue a 1,29 ?ace a?ae ii/aoeiaiai ??aiy ? aeinoia??ii ia a?ae??ciyeanue a?ae iieacieea o caei?iaeo ii?iae?eue, a i?e aeienoe? o iaoe??ioie a?oie ni?anoaaeaiiy aeaiee iieaciee caeeoaany a 1,37 ?ace iaioei ii?iaeueiiai cia/aiiy. Oe?eeii aiaeia?/i? oaiaeaioe?? ?a?no?oaaeenue ? c aieo ai?noo eiiieaiaioo. Oaeei /eiii, aeeth/aiiy aei oa?ai?? I? i?aia?ao?a oeiona, oieioa?ieo aoeaoaoo ? ia?i?aeeio ni?ey? e?ea?aeaoe?? e?ioiiai??, a?aeiiaeaiith ni?aa?aeiioaiiy ?aaoeyoi?ieo noaiiioeyoe?e, aeoeaaoe?? ooieoe?iiaeueieo ni?iiiaeiinoae e?ioioeeo?a, i?eai?/aiith aooi?ioiieo ? ?ioiieiiieaenieo ?aaeoe?e, i?aeaeuaiith ai?noo ne?iaaoeiaeo ?ioiiaeiaoe?i?a, aeoeaaoe?? nenoaie IA?. AENIIAEE 1. ?icaeoie i?neyiieiaiai? ?ioaeoe?? oa?aeoa?eco?oueny iayai?noth neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??, ui i?iyaey?oueny ca?eueoaiiyi ai?noo o ne?iaaooe? e?ia? ?a/iaei na?aaeiuei? iieaeoey?ii? iane ? noi?iaiaeaeo?oueny i?aeaeuaiiyi ?ioaineaiino? i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a, i?eai?/aiiyi aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo. 2. O ii?iae?eue c ai?eii-caiaeueieie oneeaaeiaiiyie ioa?ia??th iathoue i?noea ?iceaaee i?e?iaaiiaeeiai?ee, ye? iieyaathoue o aaia?ae?ciaaiiio aia?iniaci?, ci?iao ?aieia?/ieo aeanoeainoae e?ia? oa i?iieeiino? noaeeiii? no?iee. 3. ?icaeoie i?neyiieiaiai? ?ioaeoe?? a?aeaoaa?oueny ia oii? aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? ia?aaaaeii ca a?aeiiniei noi?ani?iei aa??aioii c aeoeaaoe??th aooi?ioiieo oa ?ioiieiiieaenieo ?aaeoe?e, i?eaiiaeaiiyi nenoaie i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino? oa i?aeaeuaiiyi ?ia?a?oe?eieo aeanoeainoae ne?iaaoee e?ia?. 4. Aeeth/aiiy aei eiiieaenii? oa?ai?? i?neyiieiaiai? ?ioaeoe?? oa?iaeieia?/ieo cania?a c aia?ii?ioaeoi?iith (ia?i?aeei), aioeieneaeaioiith (oieioa?ieo aoeaoao) ae??th oa ?ioiiiiaeoethth/eo i?aia?ao?a oeiona (oaeoea?i, oeiiaai, oeiae?i, oeiiioei) c ?o ?iaeea?aeoaeueiei i?aeai?ii a oanoao in vitro ni?ey? ciaioaiith ae?aaeaiino? neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??, ii?iae?caoe?? i?e?iaaiioee?eoeyoe??, a?aeiiaeaiith ?ioiiiai aiiainoaco ? aeoeaaoe?? i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino?. 5. Cai?iiiiiaaiee eiiieaen i?aia?ao?a ca ?aooiie aaeaeaaoii? ei?aeoe?? ?iceaae?a iaoaaie?cio, i?e?iaaiiaeeiai?ee oa ?ioi?oaoo ni?ey? ciaioaiith o?eaaeino? iaoieia?/ieo neiioii?a i?neyiieiaiaeo ?ioaeoe?eieo caoai?thaaiue ? nei?i/aiith no?ie?a aini?oae?caoe??, ui aeicaiey? aaaaeaoe aeioe?eueiei aeei?enoaiiy aeacaieo cania?a aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy ii?iae?eue c ai?eiicaiaeueieie oneeaaeiaiiyie ioa?ia??th. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Na?a??iei N.I., *oa A.A., O?ieia A.I. Aeoeai?noue ia?aeeniiai ieeneaiiy e?i?ae?a oa ?ioii? ii?ooaiiy o ii?iae?eue c i?neyiieiaiaith ?ioaeoe??th ia oii? iaoieia?/ii? e?iaiao?aoe o iieiaao // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.- 1997.- ? 3.- N. 72-74. 2. Na?aeaiei N.I. Eiioiiua ia?ooaiey o ?iaeeeueieoe n iaoieiae/aneie e?iaiiioa?ae a ?iaeao // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.- 1997.- O. 2, ? 1.- N. 45-47. 3. Na?aeaiei N.I. Iaoiaaiaoe/aneay ?ieue anoanoaaiiiai eiaeae?othuaai oaeoi?a a eiioiiuo ia?ooaieyo o ?iaeeeueieoe n iaoieiae/aneie e?iaiiioa?ae // Iaaeeei-nioeeaeueiua i?iaeaiu naiuee.- 1997.- O. 2, ? 2.- N. 147-149. 4. Na?aeaiei N.I. Iaoiaaiaoe/aneay ?ieue eiioiiuo e iee?ioee?eoeyoi?iuo ia?ooaiee i?e o?iie/aneeo caaieaaaieyo aaiaoiaeeea?iie nenoaiu o aeaiuei aeaoi?iaeiiai aic?anoa, i?iaeeaathueo a eiaeono?eaeueiii ?aaeiia Aeiiaanna // E?ea?nueea ni?aaa.- 1997.- ? 6.- N. 45-48. 5. Aa?eeye E.?., Na?aeaiei C.I., Oaeiaeea I.A., Oa?aoei A.A., A?aaeiaaa TH.A. Eiioiiua iieacaoaee o aeaiuei aeaoi?iaeiiai aic?anoa, i?iaeeaathueo a oneiaeyo e?oiiiai eiaeono?eaeueiiai ?aaeiia Aeiiaanna // E?ea?nueea ni?aaa.- 1998.- ? 2.- N. 36-38. 6. Na?a??iei N.I.  Iaoiaaiaoe/ia ?ieue neiae?iio iaoaaie?/ii? ?ioieneeaoe?? a ?icaeoeo ?ioiiaeao?oeeoo i?e i?neyiieiaiaeo ?ioaeoe?eieo caoai?thaaiiyo // Oe?a?inueeee iaaee/iee aeueiaiao.- 1999.- O. 2, ? 1.- N. 127-130. 7. Oaeiaeea I.A., Na?aeaiei N.I. Eiioiieiae/aneea iieacaoaee o aeaiuei aeaoi?iaeiiai aic?anoa, ceioiio?aaeythueo aeeiaieai // A?o?a ineo?ao???. - 1998. - ? 2, 3 (17, 18). - N. 92-95. 8. Na?aeaiei N.I. Yooaeoeaiinoue i?eiaiaiey eiioiiiiaeoeyoi?ia e aioeieneaeaioia aeey ei??aeoeee oeeoiaaiaoe/aneeo e eiioiiuo naeaeaia o ?iaeeeueieoe, i?iaeeaathueo a iaaeaaii?eyoiuo yeieiae/aneeo oneiaeyo // I?iaeaie iaaee/ii? oa aeieia?/ii? aaiaoeee: Ca??iee iaoeiaeo i?aoeue.- Ee?a-Eoaainuee, 1996.- C. 179-183. 9. Na?aeaiei N.I. Iieacaoaee eiioiiiai e iaoaaiee/aneiai aiiainoaca, iee?iaaiiaeeiaieee e eo ei??aeoeey o ?iaeeeueieoe n iinea?iaeiaie eioaeoeeae // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee, 1997.- Aeione 2 (10) - C. 169-175. 10. Na?a??iei N.I. ?ioii? ii?ooaiiy oa ?iceaaee i?e?ioee?eoeyoe?? o ii?iae?eue c i?neyiieiaiaith ?ioaeoe??th.- Aeooaeuei? ieoaiiy aeooa?noaa ? a?iaeieia??, ee?i?/ii? ?ioiieia?? oa iaaee/ii? aaiaoeee: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee, 1998. - Aeione 2 - C. 165-169. 11. Na?a??iei N. I. Aieea i?aia?ao?a oeiona, ia?i?aeeio ? oieioa?ieo ia iieacieee ?ioi?oaoo oa ia?aeeniiai ieeneaiiy e?i?ae?a o ii?iae?eue c ai?eii-caiaeueieie oneeaaeiaiiyie // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee, 1998.- Aeione 2 (16).- C. 145-155. 12. *oa A.A., Na?a??iei N.I., Aieyinueeee TH.E. Ao?ieia?/ia no?oeoo?a i?neyiieiaiaeo ?ioaeoe?eieo caoai?thaaiue a no/anieo oiiaao // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee, 1998. - Aeione 3 (17). - C. 293-309. 13. Na?a??iei N.I. Aeeiai?ea ee?oeiieo oaeoi??a ?ioi?oaoo o ii?iae?eue c i?neyiieiaiaeie ai?eii-caiaeueieie oneeaaeiaiiyie // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee-Oa?e?a, 1998. - Aeione 4 (18).- C. 133-139. 14. *oa A.A., Na?a??iei N.I. Ii?ooaiiy ?ioiieia?/iiai oa iaoaaie?/iiai aiiainoaco o ii?iae?eue c i?neyiieiaiaith ?ioaeoe??th // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee, 1999. - Aeione 2 (22).- C. 124-132. 15. *oa A.A., Na?a??iei N.I. Noai ianiaoeeo?/ii? aioe?ioaeoe?eii? ?acenoaioiino? oa ei?aeoe?y ?? ?iceaae?a o ii?iae?eue c i?neyiieiaiaith ?ioaeoe??th // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca??iee iaoeiaeo i?aoeue. - Ee?a-Eoaainuee-Oa?e?a, 1999.- Aeione 3 (23). - C. 146-159. 16. *oa A.A., Na?a??iei N.I. Canoinoaaiiy ?ioiiei?aeoi??a o oa?ai?? i?neyiieiaiai? ?ioaeoe?? // ?ioaeoe?ei? oai?iae: ca??iee iaoeiaeo ?iaio.- Aeione V.- Euea?a: "Aneoeai", 1997.- N. 42-43. 17. *oa A.A., Na?a??iei N.I. Noai ?ioiieia?/iiai noaoono o ii?iae?eue c ai?eii-naioe/ieie oneeaaeiaiiyie // Iaoeia? caienee (ca iaoa??aeaie ae?cii? nan?? Oe?a?inueei? aeaaeai?? iaoe iaoe?iiaeueiiai i?ia?ano).- Ee?a, 1997.- Aei. 1, /anoeia II.- N. 537-538. 18. Na?aeaiei N.I, Ieeieaaa Ae.A. I ?iee anoanoaaiiiai eiaeae?othuaai oaeoi?a e ia?aeeniiai ieeneaiey eeieaeia a iaoiaaiaca iinea?iaeiaie eioaeoeee ia oiia iaoieiae/aneie e?iaiiioa?e a ?iaeao.- Iao/iua o?oaeu nio?oaeieeia iaaeeoeeineiai oieaa?neoaoa e a?a/ae i?aeoe/aneiai cae?aaio?aiaiey.- Eoaaine, 1997.- N. 105-106. 19. Na?a??iei N.I. Canoinoaaiiy ?ioiiei?aeoi??a o oa?ai?? ai?eii-caiaeueieo caoai?thaaiue ii?iae?eue // O?c?ieia?y oa iaoieia?y ?ioi?oaoo, aaiinoaco oa ia?aeeniiai ieeneaiiy e?i?ae?a: Oace aeiiia?aeae I?aeia?iaeii? eiioa?aioe??.- Iieoaaa, 1997.- N. 78. 20. Na?aeaiei N.I., Oaeiaeea I.A., Oa?aoei A.A., A?aaeiaaa TH.A. Eiioiiua oanou a oa?aeoa?enoeea aeeyiey oeie/anee a?aaeiuo oaeoi?ia ie?oaeathuae n?aaeu ia ninoiyiea caei?iauey aeaiuei aeaoi?iaeiiai aic?anoa, i?iaeeaathueo a oneiaeyo e?oiiiai i?iiuoeaiiiai ?aaeiia // A?a??i?/i? i?iaeaie ioi?iie caei?ia’y ianaeaiiy: Iaoa?. tha?eaeii? iaoeiai-i?aeoe/. eiio. - Aei?i?iiao?ianuee, 1997. - N. 166-167. AIIOAOe?ss Na?a??iei N.I. Iaoaaie?/i?, i?e?iaaiiaeeiai?/i? oa ?ioiieia?/i? ii?ooaiiy a iaoiaaiac? i?neyiieiaiai? ?ioaeoe?? o ii?iae?eue oa ?o ei?aeoe?y. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 - aeooa?noai ? a?iaeieia?y. - Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. A aeena?oaoe?? aeeeaaeaii ?acoeueoaoe aea/aiiy o 125 ii?iae?eue c i?neyiieiaiaith ?ioaeoe??th iaoaaie?/ieo iieaciee?a, noaio i?e?iaaiioee?eoeyoe?? oa ?ioiieia?/iiai noaoono. O an?o iaoe??ioie anoaiiaeaii ?icaeoie aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? ia?aaaaeii ca a?aeiiniei noi?ani?iei aa??aioii c aeoeaaoe??th aooi?ioiieo oa ?ioiieiiieaenieo ?aaeoe?e ? i?eaiiaeaiiyi nenoaie i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino?. Cia/io iaoiaaiaoe/io ?ieue o iinoaii? ?ioiieo ii?ooaiue i?e caiaeueieo oneeaaeiaiiyo ioa?ia??th a?ae?a?athoue iaoaaie?/i? ci?ie (iaeiie/aiiy ?a/iaei na?aaeiuei? iieaeoey?ii? iane, aeoeaaoe?y ia?ieneaeaoe?? e?i?ae?a, i?eaiiaeaiiy aioeieneaeaioiiai caoenoo) oa aaia?ae?ciaai? ?iceaaee i?e?iaaiiaeeiai?ee. Aeeth/aiiy aei eiiieaenii? oa?ai?? i?neyiieiaiai? ?ioaeoe?? ia?i?aeeio, oieioa?ieo aoeaoaoo oa i?aia?ao?a oeiona (c ?o ?iaeea?aeoaeueiei i?aeai?ii) ca ?aooiie aaeaeaaoii? ei?aeoe?? ?iceaae?a iaoaaie?cio, i?e?iaaiioee?eoeyoe?? oa ?ioi?oaoo ni?ey? i?aeaeuaiith aoaeoeaiino? e?eoaaiiy ii?iae?eue c ai?eii-caiaeueieie oneeaaeiaiiyie. Eeth/ia? neiaa: i?neyiieiaiaa ?ioaeoe?y, ia?aeenia ieeneaiiy e?i?ae?a, neiae?ii “iaoaaie?/ii?” ?ioieneeaoe??, ?ioiieia?/ia iaaeinoaoi?noue, ?ioiiei?aeoe?y. AIIIOAOeEss Na?aeaiei N. I. Iaoaaiee/aneea, iee?iaaiiaeeiaie/aneea e eiioiieiae/aneea ia?ooaiey a iaoiaaiaca iinea?iaeiaie eioaeoe?? o ?iaeeeueieoe e eo ei??aeoeey. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 - aeooa?noai e aeiaeieiaey. - Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia eco/aieth iaoaaiee/aneeo, iee?iaaiiaeeiaie/aneeo, eiioiieiae/aneeo ?anno?ienoa, enneaaeiaaieth iaoiaaiaca ia?ooaiee eiioiiiai noaoona i?e iinea?iaeiauo eioaeoeeiiiuo caaieaaaieyo e ?ac?aaioea ?aoeeiiaeueiiai iaoiaea ea/aiey aeaiiie iaoieiaee n i?eiaiaieai ia?ieaeeia, oieioa?iea aoeaoaoa e i?aia?aoia oeiona (oaeoeaei, oeiiaai, oeiaeei, oeiiioei) n eo eiaeeaeaeoaeueiui iiaeai?ii a oanoao in vitro. Iiae iaaethaeaieai iaoiaeeeinue 125 ?iaeeeueieoe n iinea?iaeiaie eioaeoeeae (IE) a aic?anoa io 16 aei 38 eao. Ana iaoeeaioee auee ?iaei?ac?aoaiu /a?ac anoanoaaiiua ?iaeiaua iooe. Ianeaaeoaiua aeaiueiu, iiieii iauai?eiyouo eeeieei-eaai?aoi?iuo iaoiaeia enneaaeiaaiee, iiaeaa?aaeenue niaoeeaeueiui oanoai aeey ii?aaeaeaiey eioaineaiinoe i?ioeannia ia?aeeniiai ieeneaiey eeieaeia (IIE), aeoeaiinoe oa?iaioia aioeieneaeaioiie caueou (AIC), eiioeaio?aoeee aauanoa n?aaeiaiieaeoey?iie iannu (NI), eco/aiey iee?iaaiiaeeiaie/aneeo ia?ooaiee, ninoiyiey eiioieoaoa e nenoaiu anoanoaaiiie aioeeioaeoeeiiiie ?acenoaioiinoe (AA?). N?aaee ianeaaeiaaiiuo iaoeeaioie ? yoai aaia?aeecaoeee eioaeoeee (yiaeiiao?eo, iinea?iaeiaay ycaa) aeeaaiinoe?iaai o 73 eeoe (58,4%), ?? aoai (iao?eo, aaeiaeneo, o?iiaioeaaeo iaoi/iuo aai, iaeueaeiia?eoiieo) 52 (41,6%). Onoaiiaeaii, /oi o iaoeeaioie n iinea?iaeiauie aiieiiainiaeeoaeueiuie ineiaeiaieyie (AAI) cia/eoaeueii iiauoathony eiioeaio?aoeee a nuai?ioea e?iae eiia/iiai e i?iiaaeooi/iiai iaoaaieeoia IIE (iaeiiiaiai aeeaeueaeaaeaea e aeeaiiauo eiiuthaaoia niioaaonoaaiii). I?e yoii nieaeaaony iieacaoaeue ia?aeeniie ?acenoaioiinoe y?eo?ioeeoia, /oi oeacuaaao ia ?acaeoea aeanoaaeeecaoeee eeaoi/iuo iaia?ai. Oaeaea ca?aaeno?e?iaaii oiaiueoaiea aeoeaiinoe oa?iaioia AIC – eaoaeacu e noia?ieneaeaeeniooacu, /oi auei i?iyaeaieai enoiuaiey aioeieeneeoaeueiie caueou. Eiaei ianoi cia/eoaeueii iiauoaiea niaea?aeaiey a e?iae NI, /oi iicaieyei eiinoaoe?iaaoue ?acaeoea i?e iinea?iaeiauo eioaeoeeiiiuo caaieaaaieyo neiae?iia “iaoaaiee/aneie” eioieneeaoeee (NIE). Oeacaiiua eciaiaiey auee ieieiaeueiuie o ?iaeeeueieoe n yiaeiiao?eoaie e iaeaieaa au?aaeaiiuie i?e iaeueaeiia?eoaieoao e iao?io?iiaioeaaeoa. A iee?ioee?eoeyoi?iii ?onea o aeaiuei n IE onoaiiaeaiu caiaaeeaiea e?iaioiea a iee?ioee?eoeyoi?iii ?onea, ?acaeoea neaaeaeoaiiiaia, oiaiueoaiea /enea ooieoeeiie?othueo eaieeey?ia, ioeeiiaiey a?oa?eiei-aaioey?iiai niioiioaiey, ia?eaaneoey?iua ioaee e iee?iaaii??aaee. Yoe naeaeae naeaeaoaeuenoaiaaee i aaia?aeeciaaiiii aiaeiniacia e iiauoaiee i?iieoeaaiinoe ninoaeenoie noaiee, a eo au?aaeaiiinoue i?ia?anne?iaaea i?e oneeaiee oyaeanoe IE. O anao iaoeeaioie n AAI iinea?iaeiaiai ia?eiaea onoaiiaeaii ?acaeoea Oeeioiiaiee. I?e yoii eiaei ianoi cia/eoaeueiia nieaeaiea /enea Ooaeia?ia i?e i?aeoe/anee iaeciaiiii o?iaia Onoi?anni?ia. Ia?yaeo n eiee/anoaaiiuie eciaiaieyie, a eeaoi/iii caaia eiioieoaoa ?aaeno?e?iaaeinue oaiaoaiea ooieoeeiiaeueiuo naienoa eiioiioeeoia – aeanoo?ainoi?iaoeeiiiie aeoeaiinoe. Onoaiiaeaii oi?ie?iaaiea aooinaineaeeecaoeee eeioioeeoia e aeoeaaoeey aooieiioiiuo ?aaeoeee. I?e ?acaeoee iinea?iaeiaie eioaeoeee o iaoeeaioie iaaethaeaee aeii e aeeneiioiiaeiaoeeiaieth. I?e/ai iaeaieaa au?aaeaii nieaeaeenue eiioeaio?aoeee nuai?ioi/iuo eiioiiaeiaoeeiia eeannia M e G. Oaeaea eiaei ianoi iiauoaiea niaea?aeaiey oee?eoee?othueo eiioiiuo eiiieaenia i?aeiouanoaaiii ca n/ao iaeaieaa iaoiaaiiuo n?aaeia- e iaeeiiieaeoey?iuo o?aeoeee. Ni noi?iiu nenoaiu AA? onoaiiaeaii, /oi i?e IE i?ienoiaeeo nouanoaaiiia oaiaoaiea eae aoii?aeueiuo, oae e eeaoi/iuo oaeoi?ia ianiaoeeoe/aneie ?aaeoeaiinoe. O iaoeeaioie n AAI iinea?iaeiaiai ia?eiaea ioia/aii iiauoaiea eiaeae?othueo naienoa nuai?ioee e?iae, /oi io?aaeaao iaeiieaiea a e?iayiii ?onea anoanoaaiiiai eiaeae?othuaai oaeoi?a (AEO). Onoaiiaeaii nouanoaaiiia cia/aiea ?acaeoey NIE e iaeiieaiey AEO a iaoiaaiaca eiioiieiae/aneeo ia?ooaiee i?e IE. A eeeie/aneii ieaia oi?ie?iaaiea aieaa aeoaieie aoi?e/iie eiioiieiae/aneie iaaeinoaoi/iinoe nii?iaiaeaeaeinue aieueoae oyaeanoueth oa/aiey AAI. Aeeth/aiea a eiiieaenioth oa?aieth iinea?iaeiaie eioaeoeee ia?ieaeeia, oieioa?iea aoeaoaoa e i?aia?aoia oeiona (n eo eiaeeaeaeoaeueiui iiaeai?ii) niinianoaiaaei aeoeaaoeee oa?iaioia AIC e nieaeaieth eioaineaiinoe i?ioeannia IIE. I?e yoii oiaiueoaeinue niaea?aeaiea a nuai?ioea e?iae aauanoa n?aaeiae iieaeoey?iie iannu e eeeaeaee?iaaeenue ?anno?ienoaa iee?iaaiiaeeiaieee. O ?iaeeeueieoe n AAI, eioi?ua iieo/aee i?aaeeiaeaiiue iaie eiiieaen i?aia?aoia, i?e auienea ca?aaeno?e?iaaiu ii?iaeecaoeey eiee/anoaaiiuo e ooieoeeiiaeueiuo oa?aeoa?enoee eeioioeeoia n ainnoaiiaeaieai ii?iaeueiiai niioiioaiey ?aaoeyoi?iuo noaiiioeyoeee Oeeioioeeoia, iiauoaiea niaea?aeaiey nuai?ioi/iuo eiioiiaeiaoeeiia, oaiaoaiea eiioiieiiieaeniuo e aooieiioiiuo ?aaeoeee. Oae aea eiaei ianoi iiauoaiea aeoeaiinoe eeaoi/iuo e aoii?aeueiuo oaeoi?ia AA?. I?e ea/aiee IE n eniieueciaaieai ia?ieaeeia, oieioa?iea aoeaoaoa e i?aia?aoia oeiona, ca n/ao aaeaeaaoiie ei??aeoeee ?anno?ienoa iaoaaiee/aneiai e eiioiiiai aiiainoaca, eiaea ianoi aieaa auno?ay eeeaeaeaoeey eae iauaeioieneeaoeeiiiiai neiae?iia, oae e ianoiuo i?iyaeaiee aeaiiie iaoieiaee. A ?acoeueoaoa i?eiaiaiey i?aaeeiaeaiiiai eiiieaena n?ie ainieoaeecaoeee ?iaeeeueieoe n AAI nie?auaeny. O aeaiuei n IE iinea caaa?oaiey ea/aiey ii iauai?eiyoie noaia, ianiio?y ia en/aciiaaiea neiioiiia caaieaaaiey, nio?aiyeenue iaoaaiee/aneea, iee?iaaiiaeeiaie/aneea e eiioiiua ?anno?ienoaa. Eeth/aaua neiaa: iinea?iaeiaay eioaeoeey, ia?aeeniia ieeneaiea eeieaeia, neiae?ii “iaoaaiee/aneie” eioieneeaoeee, eiioiieiae/aneay iaaeinoaoi/iinoue, eiioiiei??aeoeey. SUMMARY Sergiyenko S.N. Metabolic, microhemodynamic and immune disorders in pathogenesis of postpartum infection at puerperas and them correction. - Manuscript. Thesis for a candidat's degree by speciality 14.01.01 - obstetric and gynecology. - Kharkov state medical university, Kharkov, 1999. In the dissertation the results of study of metabolic parameters, condition of microhemocirculation and immune homeostasis at 125 puerperas with puerperal infection are stated. The development of secondary immune insufficiency mainly on relative suppressive variant with activation of autoimmune and immunocomplex reactions and depression of nonspecific antiinfectious resistance is established at all patients. Metabolic changes (accumulation of average molecular weight substances, activation of lipid peroxidation, oppression of antiperoxid protection) and distributed microhemodynamic infringements play significant pathogenetic role in formation of immune disorders at postpartum inflammatory complications. Inclusion of parmidin, tocoferoli acetas and thymus preparations (with them individual selection) in complex therapy of puerperal infection promotes increase of efficiency of treatment puerperas with purulent complications at the expense of adequate correction of metabolic, microhemocirculation and immune disorders. Key words: puerperal infection, lipid peroxidation, immune infringements, “metabolic” intoxication syndrome, immune insufficiency, immunocorrection.

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