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Метаболічні, мікрогемодинамічні та імунологічні порушення в патогенезі післяпологової інфекції у породіль та їх корекція: Автореф. дис… канд. мед. н

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

NA?A??IEI NA?A?E IEEIEAEIAE*

OAeE 618.7-002-08:612.015.11-13-017.1

IAOAAIE?*I?, I?E?IAAIIAeEIAI?*I?OA ?IOIIEIA?*I? II?OOAIIss A IAOIAAIAC?
I?NEssIIEIAIAI? ?IOAEOe??O II?IAe?EUe OA ?O EI?AEOe?ss

14.01.01 – aeooa?noai ? a?iaeieia?y

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyeaiaeeaeaoa
iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?, IIC
Oe?a?ie.

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, i?ioani?

*oa A?eoi? Aaneeueiae/

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee eaoaae?e
aeooa?noaa ? a?iaeieia?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

I?ciaa Iaoae?y Ieeiea?aia

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aeooa?noaa oa a?iaeieia?? oaeoeueoaoo oaeineiiaeaiiy e?ea??a

aeieoi? iaaee/ieo iaoe, i?ioani?

Ua?aeia Ieeiea Ieaenaiae?iae/

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aeooa?noaa oa a?iaeieia?? ? 1

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i. I.I. Aiaiiieueoey, eaoaae?a aeooa?noaa ? a?iaeieia?? ? 1, IIC
Oe?a?ie, i. Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “__25__” eenoiiaaea 1999 ?. i 11
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.01 o
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a,
i?. Eai?ia, 4)

C aeena?oaoe??th iiaeia iciaeiieoeny a iaoeia?e a?ae?ioaoe?
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a,
i?. Eai?ia, 4)

Aaoi?aoa?ao ?ic?neaiee ” 25″ aeiaoiy 1999 ?ieo

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio _____________ Oaiueei I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. I?ioyaii inoaii?o ?ie?a a Oe?a?i? ia oii?
cieaeaiiy ia?iaeaeoaaiino? niinoa??aa?oueny oaiaeaioe?y aei c?inoaiiy
/anoioe ai?eii-caiaeueieo oneeaaeiaiue (ACO) i?neyiieiaiaiai ia??iaeo,
yea aeinyaa? 11–22% a?ae caaaeueii? e?eueeino? iieia?a
(?.A. Aiaaoe?ueiaa, 1998; ss.I. Nieuenueeee, 1996; A.E. Noaiaie?anueea,
1998). O no?oeoo?? iaoa?einueei? caoai?thaaiino? i?neyiieiaiaa ?ioaeoe?y
(I?) caeia? 1-2 i?noea, a o no?oeoo?? iaoa?einueei? nia?oiino? – 3-4
(A.I. Aaioeeianueeee, 1997; ?.?. Cae, 1997).

Ia?aaoaaiiy o noaoe?iia?? ii?iae?eue c ?ioaeoe?eieie oneeaaeiaiiyie
iio?aao? ?noioieo iaoa??aeueieo aeo?ao (?.A. Aiaaoe?ueiaa, 1997;
A.E. Ao?oiaee, 1995), i?e oeueiio oaeiae iia??oothoueny oiiae oo?eiaiiy
? ?icaeoeo iiaiia?iaeaeaiiai (O.A. Niaeoia, 1995). Oiio a no/anieo
aeiiii?/ieo oa aeaiia?ao?/ieo oiiaao, ui neeaeeny a Oe?a?i?,
i?io?eaeoeea e i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy i?neyiieiaiaeo
naioe/ieo caoai?thaaiue ? ia o?eueee ee?i?/iith, aea ? aaaeeeaith
nioe?aeueii-aeiiii?/iith i?iaeaiith (I.A. Aieaea, 1996).

Aaaaoi aaoi??a i?aee?aneththoue i?ia?aeio ?ieue noaio ?ioi?oaoo oa
nenoaie i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino? (IA?) o ?icaeoeo
I? (A.I. Caii?iaeai, I.A. Oaeo, I.I. I?ciaa, 1992; A.A. *oa oa ni?aaao.,
1997). O ?yae? i?aoeue anoaiiaeaii oi?ioaaiiy o ii?iae?eue, ye?
no?aaeaeathoue ia ACO, ii?ooaiue ?ioiieia?/iiai aiiainoaco
(TH.?. I?eieaiei, I.Ae. Ai?iaeei, 1997). I?ioa, ?ioeii? iaoai?cie
?icaeoeo ?ioiieo ?iceaae?a caeeoathoueny iaaeinoaoiuei aeine?aeaeaieie.
Ieceith aeine?aeiee?a i?aee?aneth?oueny ?noioia cia/aiiy neiae?iio
“iaoaaie?/ii?” ?ioieneeaoe??, aeoeaaoe?? ia?ieneaeaoe?? e?i?ae?a ?
?iceaae?a i?e?iaaiiaeeiai?ee a iaoiaaiac? ?ioaeoe?eiiai i?ioeano
(A.I. Ei?ioeee, A.A. Aanee?i/oe, 1988; E.E. A?iiaoaanueea, 1996). I?ioa
aei ianooiiiai /ano iaaeinoaoiuei aea/aii aca?iica’ycie i?ae
iaoaaie?/ieie, i?e?ioee?eoeyoi?ieie oa ?ioiieia?/ieie ci?iaie i?e
aeooa?nueeeo ai?eii-caiaeueieo caoai?thaaiiyo. ?nioth/? iaoiaee
e?eoaaiiy i?neyiieiaiai? ?ioaeoe?? ia caaaeaee a?aoiaothoue ci?ie
iaoaaie?/ieo, i?e?ioee?eoeyoi?ieo oa ?ioiieo iieaciee?a, a oiio a
aeayeeo aeiaaeeao ? iaaeinoaoiuei aoaeoeaieie ? iio?aaothoue
iiaeaeueoiai oaeineiiaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue a?aeiia?aeii aei ?anioae?eainueei? eiiieaenii?
i?aea?aeii/i? i?ia?aie “I?io?eaeoeea caoai?thaaiue oa oi?ioaaiiy
caei?iaiai niiniao aeeooy ianaeaiiy Oe?a?ie ia ia??iae aei 2000 ?ieo” oa
iniiaiiai ieaio IAe? Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?
? o?aaiaioii IAe? “?ic?iaea nenoaie ?ioiieia?/iiai iii?oi?eiao oa
?ioii?aaa?e?oaoe?? ?ia?oiee?a iniiaieo aaeocae aaeeeiai i?iieneiaiai
ae?iaieoeoaa ? a?oi ?eceeo ianaeaiiy i?iieneiai? ciie Aeiiaano”
(? aea?ae?a?no?aoe?? 019000242).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei aea/aiiy
iaoiaaiaoe/ii? ?ie? iaoaaie?/ieo, i?e?ioee?eoeyoi?ieo oa ?ioiieo
?iceaae?a o ?icaeoeo ai?eii-caiaeueieo caoai?thaaiue ioa?ia??th oa
ee?i?ei-iaoiaaiaoe/ia iaa?oiooaaiiy caniao e?eoaaiiy ii?iae?eue c
i?neyiieiaiaith ?ioaeoe??th c aeeth/aiiyi ia?i?aeeio, oieioa?ieo
aoeaoaoo oa i?aia?ao?a oeiona.

Aeey ?aae?caoe?? aeaii? iaoe aeine?aeaeaiiy iinoaaeai? ianooii?
eiie?aoi? caaea/?:

1. Aeine?aeeoe ae?aaeai?noue neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??,
aeoeai?noue ia?ieneaeaoe?? e?i?ae?a oa noai nenoaie aioeieneaeaioiiai
caoenoo o ii?iae?eue c I?.

2. I?iaiae?coaaoe oa?aeoa? i?e?iaaiiaeeiai?/ieo ?iceaae?a i?e ACO
ioa?ia??th.

3. Aea/eoe noai ?ioi?oaoo oa aeaye? iieacieee i?e?iaeii?
aioe?ioaeoe?eii? ?acenoaioiino? o iaoe??ioie c I?.

4. Aecia/eoe ee?i?/io aoaeoeai?noue eiiieaeno ia?i?aeeio, oieioa?ieo
aoeaoaoo oa i?aia?ao?a oeiona i?e ?o ?iaeea?aeoaeueiiio i?aeai?? a
oanoao ?n v?tro i?e e?eoaaii? ii?iae?eue c i?neyiieiaiaeie ACO.

5. Anoaiiaeoe aieea cai?iiiiiaaiiai caniao e?eoaaiiy ia aeeiai?eo
iaoaaie?/ieo iieaciee?a, noai i?e?iaaiiaeeiai?ee oa ?ioiieia?/iee noaoon
o iaoe??ioie c I?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Io?eiai? aeai? i?i nooi?iue
ae?aaeaiino? neiae?iio “iaoaaie?/ii?” ?ioieneeaoe??,
i?e?iaaiiaeeiai?/ieo ii?ooaiue oa ai?no i?e?iaeiiai ?ia?aoth/iai oaeoi?a
o iaoe??ioie c ACO ioa?ia??th.

Aecia/ai? iniaeeaino? ?iceaae?a ?ioi?oaoo oa i?e?iaeii? aioe?ioaeoe?eii?
?acenoaioiino? o ii?iae?eue c I?.

Aeine?aeaeaii aca?iica’ycie aaee/eie e?iaiao?aoe, oyaeeino?
i?neyiieiaiai? ?ioaeoe?? c ae?aaeai?noth iaoaaie?/ieo, ?ioiieia?/ieo e
i?e?ioee?eoeyoi?ieo ?iceaae?a.

Anoaiiaeaii iaoiaaiaoe/ia cia/aiiy i?e?iaeiiai ?ia?aoth/iai oaeoi?a,
ci?i iaoaaie?/iiai aiiainoaco ? ii?ooaiue i?e?iaaiioee?eoeyoe?? o
oi?ioaaii? aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? o ii?iae?eue c
i?neyiieiaiaeie ?ioaeoe?eieie caoai?thaaiiyie.

Iaoiaaiaoe/ii iaa?oioiaaia aeioe?euei?noue aeeth/aiiy aei eiiieaenii?
oa?ai?? I? cania?a c aioeieneaeaioiith ? aia?ii?ioaeoi?iith ae?yie oa
i?aia?ao?a oeiona (c ?o ?iaeea?aeoaeueiei i?aeai?ii a oanoao in vitro).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? e?eoa??? aeey
i?iaiicoaaiiy ?icaeoeo i?neyiieiaiaeo ACO c aeei?enoaiiyi ?ioiieia?/ieo
oa a?io?i?/ieo aeine?aeaeaiue. Oae, i?e ai?no? “na?aaei?o iieaeoe” a
ne?iaaooe? e?ia? ii?iae?ee? 0,69 a/e e aeua oa cia/aii? ?iaeaeno
?ia?a?oe?? 1,5 ? a?eueoa iiaeia i?iaiicoaaoe c a??ia?aei?noth 85,4±3,2%
aeieeiaiiy i?neyiieiaiaiai caoai?thaaiiy.

Aecia/ai? ?ioiieia?/i? oa a?io?i?/i? iieacieee, aeeiai?ea yeeo aeicaiey?
ioe?ithaaoe aoaeoeai?noue i?iaaaeaiiai e?eoaaiiy ii?iae?eue c I?, a naia
ciaioaiiy ?iaeaeno ?ia?a?oe?? aei 1,1-1,2 oa ciaioaiiy ai?noo “na?aaei?o
iieaeoe” aei 0,58-0,60 a/e.

?ic?iaeaia ? ii?aoeueiaaia ?aoe?iiaeueia, iaoiaaiaoe/ii iaa?oioiaaia
noaia eiiieaenii? oa?ai?? ACO o ii?iae?eue ?c canoinoaaiiyi oieioa?ieo
aoeaoaoo, ia?i?aeeio oa i?aia?ao?a oeiona c ?o ?iaeea?aeoaeueiei
i?aeai?ii a oanoao ?n v?tro.

Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeai? a ee?i?/io
i?aeoeeo 11 aeooa?nueeeo oa a?iaeieia?/ieo a?aeae?eaiue Eoaainueea oa
iaeano?. Io?eiai? aeai? aeeth/ai? aei o/aiaiai i?ioeano eaoaae?
aeooa?noaa ? a?iaeieia?? oaeoeueoaoo i?neyaeeieiiiiai iaa/aiiy oa
e?eoaaeueiiai oaeoeueoaoo EAeIO.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeaii
caaaeueiiee?i?/ia oa aeooa?nueei-a?iaeieia?/ia ianoaaeaiiy 125
ii?iae?eue, oai?eo ia ACO ioa?ia??th, aeai? i?i yeeo iaaiaeyoueny o
aeena?oaoe??. Caeiaoaa/ i?eeiaa aaciina?aaeith o/anoue o cae?eniaii?
eiiieaenieo aeine?aeaeaiue ?ioiiiai noaoono ? a?io?i?/ieo iieaciee?a oa
ioe?ioe? i?e?iaaiiaeeiai?ee. Naiino?eii aeeiiai? ?ioiieia?/i? oanoe o 85
niinoa??aa?ieo iaoe??ioie, a?io?i?/i? aeine?aeaeaiiy – o 67 oa aea/aiiy
i?e?ioee?eoeyoe?? – o 54 ii?iae?eue. Niiooeoaa/ai aoa ?ic?iaeaiee ?
cai?iaaaeaeaiee a ee?i?/io i?aeoeeo can?a e?eoaaiiy ii?iae?eue c
i?neyiieiaiaith ?ioaeoe??th c aeeth/aiiyi aioeieneaeaioo,
aia?ii?ioaeoi?o oa ?ioiiiiaeoeyoi?a, i?iaaaeaia ioe?iea eiai
aoaeoeaiino? c o?aooaaiiyi aeeiai?ee a?io?i?/ieo oa ?ioiieia?/ieo
iieaciee?a ? noaio i?e?ioee?eoeyoe??. Naiino?eii aeeiiaia noaoenoe/ia
ia?iaea io?eiaieo ee?i?/ieo ? eaai?aoi?ieo aeaieo oa iieaciee?a
niaoe?aeueieo a?io?i?/ieo oa ?ioiieia?/ieo oano?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ? ?acoeueoaoe
aeaii? ?iaioe aeiiia?aeaeenue oa iaaiai?thaaeenue ia ?aa?iiaeuei?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeieia?y i?iieneiaiai ?aa?iio Aeiiaano”
(Eoaainuee, 1995), iaoeiai-i?aeoe/i?e eiioa?aioe?? “A?a??i?/i? i?iaeaie
ioi?iie caei?ia’y ianaeaiiy” (Aei?i?iiao?ianuee, 1997), I?aeia?iaei?e
eiioa?aioe?? “O?c?ieia?y oa iaoieia?y ?ioi?oaoo, aaiinoaco oa
ia?aeeniiai ieeneaiiy e?i?ae?a” (Iieoaaa, 1997), 1-io I?aeia?iaeiiio
iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1997),
ae?ci?e nan?? Oe?a?inueei? aeaaeai?? iaoe iaoe?iiaeueiiai i?ia?ano
(Oa?iii?eue, 1997).

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 148
noi??ieao iaoeiiieno oa aeeth/a? anooi, iaeyae e?oa?aoo?e, 5 ?icae?e?a
aeanieo aeine?aeaeaiue, ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy,
aeniiaee. Nienie aeei?enoaieo aeaea?ae neeaaea? 169 a?o/eciyieo oa 90
?iicaiieo e?oa?aoo?ieo iineeaiue. Iaoa??aee aeena?oaoe?? ?ethno?iaaii 20
oaaeeoeyie, 18 ?enoieaie ? 5 ee?i?/ieie niinoa?aaeaiiyie.

Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaai? a 20 iaoeiaeo
?iaioao, a oiio /ene? a 15 noaooyo (c ieo 9 iaeiiin?aieo) o oaoiaeo
aeaeaiiyo, caoaa?aeaeaieo AAE Oe?a?ie (7 a aeo?iaeao ? 8 o ca??ieeao
iaoeiaeo i?aoeue) oa 5 oacao aeiiia?aeae ia iaoeiaeo eiioa?aioe?yo ?
neiiic?oiao.

INIIAIEE CI?NO

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. I?ae iaaeyaeii ciaoiaeeeinue 125
ii?iae?eue c i?neyiieiaiaeie ai?eii-caiaeueieie caoai?thaaiiyie. A?e
ianoaaeaieo ae?iie aoa o iaaeao a?ae 16 aei 38 ?ie?a. An? niinoa??aa?i?
ii?iae?ee? aoee ?ic?iaeaeai? e??cue i?e?iaei? iieiaia? oeyoe.

C iaoith aecia/aiiy aoaeoeaiino? cai?iiiiiaaiiai eiiieaeno i?aia?ao?a
ii?iae?ee? c ACO ca aeiaaeeiaith iciaeith aoee ?iciiae?eai? ia aea?
a?oie, ye? aoee ni?anoaaeieie ca na?aaei?i a?eii, ia?eoaoii, oiiaaie
iaoeaiiy oa oyaee?noth ia?aa?ao I?. Iaoe??ioee iniiaii? a?oie (62 iniae,
49,6%) ii?yae c o?aaeeoe?eiith oa?ai??th i?ioyaii 10–12 aei?a io?eioaaee
ia?i?aeei, oieioa?ieo aoeaoao oa iaeei c i?aia?ao?a oeiona (oaeoea?i,
oeiae?i, oeiiaai, oeiiioei) i?ney eiai ?iaeea?aeoaeueiiai i?aeai?o a
oanoao ?n v?tro. AE?iee a?oie ni?anoaaeaiiy (63 iniae, 50,4%) io?eioaaee
e?eoaaiiy o?eueee ca ocae/a?iith noaiith.

sse ?aa?iiaeuei? ii?ie ?ioiieia?/ieo, iaoaaie?/ieo iieaciee?a oa noaio
i?e?iaaiiaeeiai?ee o ii?iae?eue aeei?enoiaoaaee aeai? i?aeeaoaae?aeueii?
eaai?aoi??? EAeIO, ui io?eiai? a ?acoeueoao? ianoaaeaiiy 50 caei?iaeo
ae?iie c o?c?ieia?/iei ia?aa?aii i?neyiieiaiaiai ia??iaeo.

An? iaoe??ioee i?aeeyaaee aeeiai?/iiio ianoaaeaiith, yea aeeth/aei o
naaa o?ceeaeueia oa aeooa?nueei-a?iaeieia?/ia ina?ae/aiiy,
caaaeueiii?eeiyo? eaai?aoi?i? aeine?aeaeaiiy, a oaeiae eiiieaen
niaoe?aeueieo a?io?i?/ieo, ?ioiieia?/ieo oano?a ? aea/aiiy noaio
i?e?ioee?eoeyoi?iiai ?onea (IOe?).

Aecia/aiiy ao?ieia?/iiai oaeoi?a i?neyiieiaiaeo caoai?thaaiue
cae?enithaaee caniaii na??eieo ?icaaaeaiue a?aeae?ey?iiai c ina?aaee?a
caiaeaiiy iaoa??aeo, c ianooiiei aen?aii ia aeaeoeai?, naeaeoeai? oa
aeeoa?aioe?eii-ae?aaiinoe/i? na?aaeiaeua. Aeine?aeaeaiiy /ooeeaino?
i?e?ii?aai?ci?a aei aioea?ioee?a i?iaiaeeee iaoiaeii aeeooc?? a aaa? ?c
canoinoaaiiyi noaiaea?oieo iaia?iaeo aeene?a oeyoii na??eieo
?icaaaeaiue. Ao?ieia?/ia ae?aaiinoeea i?iaiaeeeanue c o/anoth oa
iaoiaee/iith aeiiiiiaith ni?a?ia?oiee?a Oa?e?anueeiai IAe? i?e?ia?ieia??
? ?ioiieia?? ?i. ?.?. Ia/ieeiaa (aee?aeoi? – TH.E. Aieyinueeee).

Ai?no o ieaci? “na?aaei?o iieaeoe” (NI) ioe?ithaaee niaeo?ioioiiao?e/iei
iaoiaeii (A.A. I?eieae/ee oa ni?aaao., 1991). I?i ?ioaineai?noue
ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) noaeeee ca eiioeaio?aoe?yie a
ieaci? e?ia? iaeiiiaiai aeeaeueaeaa?aeo (IAeA) ? ae??iiaeo eii’thaao?a
(AeE) oa cia/aiiyi iieacieea ia?aeeniiai aaiie?co a?eo?ioeeo?a (IAA)
(A.I. Ei?iaaeieeiaa, 1989). Aeoeai?noue oa?iaio?a nenoaie
aioeieneaeaioiiai caoenoo (AIC) – eaoaeace (EO) oa noia?ieneaeaeeniooace
(NIAe) aecia/aee niaeo?ioioiiao?e/iei iaoiaeii (N. *aaa?? oa ni?aaao.,
1991). Aeey noaeaeaiiy i?i aca?iia?aeiioaiiy i?ae ci?iaie ?ioaineaiino?
IIE oa eiiiainaoi?ieie cae?aiinoyie AIC ia/enethaaee ?iaeaen O, yeee
aei??aith? aeiaooeo cia/aiue aeoeaiino? NIAe ? EO, iiae?eaiiio ia
eiioeaio?aoe?th IAeA (N. *aaa?? oa ni?aaao., 1991).

Noai i?e?iaaiioee?eoeyoe?? aea/aee caniaaie a?ii?e?ineii?? aoeueaa?ii?
eii’thieoeae (AAE) (c ioe?ieith ii?ooaiue ca aaeueiith nenoaiith
eii’thieoeaaeueieo ?iaeaen?a (E?)), eai?ey?ineii?? oa iooaeueiineii??
(N.A. Naeaciueia oa ni?aaao., 1985).

E?euee?nio ioe?ieo noaio ?ioi?oaoo i?iaiaeeee oeyoii i?ae?aooieo /enea
A, O-e?ioioeeo?a oa ?o iniiaieo ?aaoeyoi?ieo noaiiioeyoe?e a
oeeoioiene/iiio oano? c iiiieeiiaeueieie aioeo?eaie (IA) (A.I. O?ieia oa
ni?aaao, 1989). Aeei?enoiaoaaee eiia?oe?ei? IA o??ie “Ortho D?agnost?c
Systems Inc.” (USA) aeey ?aeaioeo?eaoe?? e?ioioeeo?a c oaiioeiii CD3+
(oioaeueia iiioeyoe?y Oee?oei), CD4+ (Ooaeia?e/?iaeoeoi?e), CD8+
(Onoi?ani?e/e?ea?e), CD22+ (Ae?ioioeeoe); ia/enethaaee ?ioii?aaoeyoi?iee
?iaeaen CD4/CD8. Ooieoe?iiaeueio aeoeai?noue e?ioioeeo?a aecia/aee a
?aaeoe?? aeanoo?ainoi?iaoe?? (?AOE), ye niiioaii?e, oae ? c
o?oiaaiaaethoei?iii (OAA). Nooi?iue nainea?e?caoe?? ?ioiioeeo?a aei
oeaiaaeo aooiaioeaai?a aea/aee a ?aaeoe?? aaeueioaaiiy i?a?aoe??
e?ioioeeo?a (?AIE) c e?iii?ioa?aeii ia/?iee (EIE), aioeaaiaie oeiona
(OA), aiaeiiao??th (AiA) oa i?iiao??th (IiA) (A.O. *a?iooaiei, 1988).

?c aoii?aeueieo iieaciee?a ?ioi?oaoo aecia/aee eiioeaio?aoe??
?ioiiaeiaoe?i?a (Ig) eean?a A, M, G o ne?iaaooe? e?ia? iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? (G. Mancini et al., 1965). Ai?no
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) oa ?o o?aeoe?eiee neeaae
aeine?aeaeoaaee iaoiaeii aeeoa?aioe?eii? i?aoeei?oaoe?? o 2%, 3,5% oa 6%
?ic/eiao iie?aoeeaiae?eieth (A.I. O?ieia oa ni?aaao., 1990). ??aaiue o
ieaci? I?O ioe?ithaaee ca cia/aiiyi ?iaeaeno ?ia?a?oe?? (??) ?aaeoe??
?ia?a?thaaiiy aeoeaiino? ne?iaaoeiaeo aioeo?e (??A) (I.A. AEo?aaeueiaa
oa ni?aaao., 1988).

Oaaioeeoa?io aeoeai?noue iiiioeeo?a (OAI) aea/aee /aoa/eiaei iaoiaeii
(A.I. O?ieia oa ni?aaao., 1990), i?e oeueiio ia/enethaaee oaaioeeoa?iee
?iaeaen (O?), oaaioeeoa?ia /enei (O*), ?iaeaen ao?aeoe?? (?A) oa ?iaeaen
ia?ao?aaethaaiiy (?I). Aeoeai?noue e?cioeeio o ne?iaaooe? e?ia? aea/aee
iaoaeiiao?e/iei iaoiaeii, ai?no eiiieaiaioo – aaiie?oe/iei iaoiaeii
oeo?oaaiiy ii 50% aaiie?co (A.N. Eicethe oa ni?aaao., 1987).

Eiiieaen aeuaaeacaieo aeine?aeaeaiue an?i ii?iae?eeyi c I? i?iaiaeeee
i?e iaaeoiaeaeaii? aei noaoe?iia?o ? /a?ac 14–16 ae?a a?ae ii/aoeo
e?eoaaiiy. I?aea?? i?aia?ao?a a oanoao ?n v?tro cae?enithaaee ca
aeiiiiiaith LAI-oanoo (E.O.*a?iooaiei, 1995).

Noaoenoe/iee aiae?c iaea?aeaieo aeaieo aeeiioaaee ia IAII eeano Pentium
?c canoinoaaiiyi i?eeeaaeieo i?ia?ai, ?ic?aoiaaieo ia ia?iaeo
iaaeeei-a?ieia?/ii? ?ioi?iaoe??. Aeey eiaeii? aea??ee ia/enethaaee
na?aaeith a?eoiaoe/io (M) oa iiieeeo ?ai?acaioaoeaiino? (m).
Aeinoia??i?noue ??cieoe? aea??eiaeo na?aaei?o aaee/ei aecia/aee ca
e?eoa???i No’thaeaioa (t). Nooi?iue aca?iica’yceo i?ae e?euee?nieie
iciaeaie aea/aee oeyoii ei?aeyoe?eiiai aiae?co c aecia/aiiyi
eiao?oe??io?a ei?aeyoe?? (r).

Ee?i?/ia oa?aeoa?enoeea ai?eiicaiaeueiex caoai?thaaiue o ianoaaeaieo
ii?iae?eue. Na?aae ianoaaeaieo iaie ii?iae?eue o 73 in?a (58,4%) aoee
anoaiiaeai? oi?ie I?, ui a?aeiia?aeathoue ? aoaio ?iciianthaeaeaiiy
iaoieia?/iiai i?ioeano, a naia aiaeiiao?eoe, i?neyiieiaia? ae?acee (1
a?oia), o 52 in?a (41,6%) – ?? aoaio, oae?, ye iao?eoe, aaeiaeneoe,
o?iiaioeaa?o iaoeiaeo aai, iaeuea?iia?eoii?oe (2 a?oia).

O ee?i?/i?e ea?oei? i?neyiieiaiaeo ACO ia?aaaaeia i?noea caeiaee
neiae?ii ?ioieneeaoe?? oa i?noeaa? i?iyaeaiiy caiaeaiiy. Neiae?ii
?ioieneeaoe?? i?e eaaeiio oa na?aaeiueioyaeeiio ia?aa?ao I?
oa?aeoa?ecoaaany iacaeoaeaiiyi, i?iianieoeath, inooaeith,
a?ia?a?ae?icii, aii?aen??th; a a?eueo oyaeeeo aeiaaeeao niinoa??aaee
oao?ea?ae?th, cieaeaiiy a?oa??aeueiiai oeneo, oeaoaea?th, aeenniii?th,
aeenoi??th. C i?noeaaeo iciae caiaeueiiai i?ioeano i?e aiaeiiao?eo? iaee
i?noea aeae?eaiiy ?c noaoaaeo oeyo?a, oiia?eueiaiiy ?iaiethoe?? iaoee,
i?e iao?eo? – a?aee?eoee iaoeiaee c?a, a?eue aieco aeeaioa oa
aie?ni?noue iaoee i?e iaeueiaoe??, i?e iaeuea?iia?eoii?o? a?aei?/aee
neiioiie iiae?aciaiiy i/a?aaeie.

Na?aae oai?eo ii?iae?eue o 110 in?a ?a?no?oaaee aiai?th. I?e oeueiio o
iaoe??ioie 2 a?oie ai?no a?eo?ioeeo?a aoa ieae/ei ia 9,1%, i?ae o
ae?iie 1 a?oie (p

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