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Механізми розвитку захворювань печінки і нирок у гірників глибоких вугільних шахт Донбасу та можливі шляхи їх профілактики: Автореф. дис… д-ра мед.

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Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?nEoao

?AA?IA AI?EN IEAEN?EIAE*

OAeE 616.12-008-24-63:622.012.2-07.2-477.61/.62

IAOAI?CIE ?ICAEOEO CAOAI?THAAIUe IA*?IEE ? IE?IE

O A??IEE?A AEEAIEEO AOA?EUeIEO OAOO

AeIIAANO OA IIAEEEA? OEssOE ?O I?IO?EAEOEEE

14.01.02 – aioo??oi? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a – 1999

16

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Eoaainueeiio aea?aeaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,
i?ioani? Ieioe?i Aieiaeeie? sseiae/,

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe:

aeaaeai?e AII, /eai-ei?aniiiaeaio IAI Oe?a?ie, caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani?

Ie??a Ethaiie? Aioiiiae/;

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea,
caa?aeoaa/ eaoaae?e iao?ieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

Nai?aeioeueea AEaiia Aeieo???aia

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?2

aeieoi? iaaee/ieo iaoe

Aoaa?a??oe Iaoaey Ai?en?aia

Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aioo??oi?o oai?ia ? 1

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. aeaae.
I.I.Aiaiiieueoey, IIC Oe?a?ie

Caoeno a?aeaoaeaoueny 24 ethoiai1999 ?. i 9 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a, i?. Eai?ia, 4).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee 12 n?/iy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

e. i. i., aeioeaio E.?. Ia/a?aieiCAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?icaeoie a??ie/i?oaeii? i?iieneiaino? Aeiiaano ia
no/aniiio aoai? oa?aeoa?eco?oueny aacia?a?aiei iia??oaiiyi oiia i?aoe?
i?aecaiieo a??iee?a aoa?eueieo oaoo [A.I.Eiaaoe, 1995; E.E.*a?eania,
1998]. C oeei iia’ycaii ca?eueoaiiy caoai?thaaiino? oaooa??a oa
ciaioaiiy o?eaaeino? ?o aeeooy [O.A.Eoaeeiiaa, 1990; ?.A.Oooa?aa, 1997].
Ia i?aai?ci a??iee?a aieeaa? oe?eee eiiieaen oe?aeeeaeo /eiiee?a
ae?iaieoeoaa, a naia: aaaeea o?ce/ia i?aoey, i?e?iee?iao, ui iaa??aa?,
caa?oaeiaiiy iia?o?y, ?ioaineaiee ooi, a?a?aoe?y, i?aeaeuaiee
aa?iiao?e/iee oene, ae?y o?i?/ieo ?a/iaei, a?iien?y oa i?aeaeuaiee
?aae?aoe?eiee oii, ye? aeeeeeathoue ci?ie o ooieoe?iioaaii? iecee nenoai
? i?aai?a c ianooiiei ?icaeoeii o ieo iaoieia?/ieo ci?i [A.A.Iaieiaa,
1995; I.O.Ecia?ia, 1997; E.Hnizdo, 1992; N.L.Lapp, 1994].

Aeeiiaiiy aaaeeeo ?ia?o a oiiaao i?e?iee?iaoo, ui iaa??aa?, aaaea aei
?icaeoeo aino?iai oa o?ii?/iiai ia?aa??aaiiy ?ia?oiee?a [TH.A.Ao?iae,
1996; A.I.Aaeooeeia, 1996], c?inoaiiy e?eueeino? caoai?thaaiue ia/?iee
[I.A.Ea?iaoo, 1993; A.I.Iei?ieia, 1998] oa ie?ie [A.ss.Ieioeei, 1998].
I?ioa iaoiaaiac ooeiaeaeoth/iai aieeao i?aecaiiiai na?aaeiaeua ia
aioo??oi? i?aaie ethaeeie iiai?noth ia anoaiiaeaiee.

Oe?aeeea? /eiieee aeeaiei? aoa?eueii? oaooe iiaeooue ni?e/eiyoe
ii?ooaiiy ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie (?AAN),
aiaeii-nieueiaiai iai?io (ANI) oa nenoaiii? aaiiaeeiai?ee [A.M.Aeaa?nii,
1994; E.A.Ie??a, 1995; J.I.S.Robertson, 1993; B.M.Brenner, 1996], ae?y
yeeo o?nii iia’ycaia c ie?eiaei neioacii i?inoaaeaiaeei?a [N.Awan, 1996;
M.T. Llinas, 1997] ? aacii?aneiii ieacie e?ia? [R.L.Zerbe, 1994; I.Jo,
1995]. Ci?ie, ui a?aeaoaathoueny a i?aai?ci? a??iee?a i?e aeeiiaii?
aaaeeeo o?ce/ieo ?ia?o, i?ecaiaeyoue aei iiyaeaiiy i?ioa?io???
iai?oaeaiiy oa aaiaoo??? i?ney iaaaioaaeaiiy, iaoai?cie yeeo ia
c’yniaai? [E.A.Oa?aaaa, 1995; I.O.Aeoaea?, 1996; R.J.Glassock, 1996].

Eiiieaeniee aieea ae?iaie/eo /eiiee?a aaaea aei iineaaeaiiy
aioeieneaeaioiiai caoenoo [A.Ae.Eoeuyi/oe, 1995, S.Nagase, 1997] oa
?ioaineo?eaoe?? ia?aeeniiai ieeneaiiy e?i?ae?a (IIE), ye? eaaeaoue a
iniia? aeanoaa?e?caoe?? iaia?aiieo no?oeoo? ? ?icaeoeo iaoieia?/ieo
i?ioean?a [A.I.Aecoaai, 1997; M.J.Wang, 1995]. A?aecia/a?oueny, ui
?ioaineai?noue IIE o?nii iia’ycaia c? noaiii ?ioiii? ?aaeoeaiino?
i?aai?cio [A.A.Ai?aeiiin, 1993, A.O.I.Naeai, 1995], a ?? cieaeaiiy a
oiiaao ae?? oaeoi??a i?iieneiaiai ae?iaieoeoaa iiaea noaoe i?e/eiith
?icaeoeo iaoieia?? aioo??oi?o i?aai?a [A.I.O?ieia, 1998]. Na?aae
?aaoethth/eo /eiiee?a ?ioi?oaoo aaaeeeaa i?noea caeia? ai?iii oeiono
a1-oeiicei [A.A.ss?eeei, 1996]. A?euei? ?aaeeeaee, ui noai?ththoueny a
?acoeueoao? IIE, yaeythoue niaith aaaeeea? /eiieee, ye? aeeeeeathoue
ooieoe?iiaeuei? oa ii?oieia?/i? ci?ie o aioo??oi?o i?aaiao, iniaeeai a
ia/?ioe? [I.A.Ianyiieeiaa, 1995] ? ie?eao [A.N.Na?ioeeoeueeee, 1995].

Anoaiiaeaii, ui ia/?iea ? iaea?eueo /ooeeaei i?aaiii aei ae??
i?e?iee?iaoo, ui iaa??aa? [O.A.Iaaeiaa, 1995], oa o?i?/ieo ?a/iaei
[I.A.No?i?ei, 1998], cia/ou?noue yeeo i?aeneeth?oueny i?e ii?aeiaii? c
aeeiiaiiyi aaaeeeo ?ia?o, i?aeaeuaii? aa?iiao?e/iiai oeneo oa ?ioeie
/eiieeaie i?aecaiiiai na?aaeiaeua [?.A.Eiiuoeia, 1995]. I?e oeueiio
a?aei?/aii, ui i?e ia?aa??aaii? aeieeathoue no?oeoo?i? ci?ie ia/?iee
[A.I.Iiaaaeueiiiay, 1994], a iniia? yeeo eaaeeoue oieiaa ?aaeoe?y c
nenoaiiei o?aaeaiiyi i?e?ioee?eoeyoi?iiai ?onea, ye? aeyaeythoueny
aoi?eiiei ?oai?/iei ooeiaeaeaiiyi i?aaio a aeaeyae?
aeeno?io?/ii-iae?ioe/ieo ci?i [A.I.Oeoeei, 1995].

A iao /an ae?aaiinoeea ? e?eoaaiiy caoai?thaaiue ia/?iee oa
na/iaeae?eueii? nenoaie o ?ia?oiee?a i?iieneiaeo i?aei?e?inoa
a?aeaoaa?oueny, a iniiaiiio, ia noaae?? ee?i?/ieo i?iya?a oai?iae oa
iaiaaeaiiy i?aoeacaeaoiino? [?.O.Aoaianueaaa, 1997; A.I Aeaieeee.,
1997]. Aeyaeaiiy ?aii?o ii?ooaiue ooieoe?iiaeueiiai noaio aioo??oi?o
i?aai?a ? aea/aiiy iaoai?ci?a ?o ?icaeoeo aeicaieeoue ?ic?iaeoe iaoiaee
?aiiuei? i?io?eaeoeee, e?eoaaiiy oa ?aaa?e?oaoe?? a??iee?a.

Iaeiae ?ia?o, i?enay/aieo eiiieaeniiio aeine?aeaeaiith ?aii?o ii?ooaiue
ooieoe?iiaeueiiai noaio ia/?iee oa na/iaeae?eueii? nenoaie o i?aecaiieo
a??iee?a aeeaieeo aoa?eueieo oaoo, iiooeai iaoiaaiaoe/ieo iaoai?ci?a
oeeo ii?ooaiue, iaia?. I?iaaaeaiiy oaeiai aeine?aeaeaiiy ia? i?aeoe/ia
cia/aiiy, ine?eueee aiii iiaea iioe?eoe iao? oyaeaiiy i?i iaoai?cie
oi?ioaaiiy iaoieia?? ia/?iee oa ie?ie, iiaeeea? oeyoe i?io?eaeoeee,
e?eoaaiiy ? ?aaa?e?oaoe?? a??iee?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oea
aeine?aeaeaiiy (?aa.?01890069866) i?iaiaeeeiny ca ieaiii iaoeiaeo ?ia?o
eaoaae?e oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iaoa aeine?aeaeaiiy. Aeyaeoe ?aii? i?iyae oa anoaiiaeoe iaoai?cie
?icaeoeo caoai?thaaiue ia/?iee ? ie?ie o i?aecaiieo a??iee?a aeeaieeo
aoa?eueieo oaoo, ?ic?iaeoe niiniae ?o i?io?eaeoeee.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe caoai?thaai?noue a??iee?a aeeaiei? aoa?eueii? oaooe.

2. Aeyaeoe a?oio i?aeoe/ii caei?iaeo a??iee?a oa i?iaanoe ?o iiaeeaeaia
ianoaaeaiiy.

3. Aea/eoe ooieoe?iiaeueiee noai ia/?iee a??iee?a ia i?aenoaa?
aeine?aeaeaiiy a?io?i?/ieo iieaciee?a a caeaaeiino? a?ae aaaeeino?
aeeiioaaieo ?ia?o.

4. Aea/eoe noai oeaio?aeueii? aaiiaeeiai?ee a??iee?a ? aecia/eoe ?ieue
?? ci?i a ?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

5. Aecia/eoe ?ieue ?AAN, aacii?aneio, aiaeioae?io-1 ? neioaco
i?inoaaeaiaeei?a a ie?eao o aeieeiaii? ii?ooaiue ANI o i?aecaiieo
a??iee?a aeeaieeo aoa?eueieo oaoo, c’ynoaaoe iaoiaaiaoe/i? iaoai?cie
ii?ooaiue ooieoe?iioaaiiy oeeo nenoai oa ?o ?ieue a o?aaeaii? ie?ie.

6. Anoaiiaeoe iaoai?cie ?icaeoeo i?ioa?io??? iai?oaeaiiy.

7. Anoaiiaeoe iaoai?cie ?icaeoeo aaiaoo??? i?ney iaaaioaaeoaaiiy.

8. Aecia/eoe ?ieue i?e?iee?iaoo, ui iaa??aa?, a ?icaeoeo ii?oieia?/ieo
ci?i ? ii?ooaiue ooieoe?iiaeueiiai noaio ia/?iee oa ie?ie
(ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy).

9. Aeine?aeeoe noai IIE ? nenoaie aioeieneaeaioiiai caoenoo, aeyaeoe
oa?aeoa? ci?i oa aecia/eoe ?o ?ieue a ?icaeoeo caoai?thaaiue ia/?iee oa
ie?ie o a??iee?a.

10. Aea/eoe noai ?ioiiiai noaoono o i?aecaiieo a??iee?a aeeaieeo
aoa?eueieo oaoo, c’ynoaaoe oa?aeoa? ci?i oa aecia/eoe ?o ?ieue a
?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

11. ?ic?iaeoe ? i?iaanoe ai?iaaoe?th iaoiae?a i?io?eaeoeee caoai?thaaiue
aioo??oi?o i?aai?a o a??iee?a aeeaieeo aoa?eueieo oaoo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa o i?aeoe/ii caei?iaeo
a??iee?a aeeaieeo aoa?eueieo oaoo i?iaaaeaii eiiieaenia aea/aiiy ?aii?o
ii?ooaiue ooieoe?iiaeueiiai noaio ia/?iee oa ie?ie, a oaeiae noaio
ia?aeeniiai ieeneaiiy e?i?ae?a, nenoaie aioeieneaeaioiiai caoenoo oa
?ioiiiai noaoono.

Aia?oa aecia/ai? ii?ooaiiy ooieoe?? ia/?iee, ye? aeyaeythoueny a
cieaeaii? ai?noo aeueaoi?i?a o ne?iaaooe? e?ia?, iniaeeai cia/iiio o
iieiaeeo a??iee?a oa a??iee?a c i?aecaiiei noaaeai aei 5 ?ie?a;
a?aeiiniiio i?aeaeuaii? ??ai?a o?ainai?iac, ??aiy oieanoa?eio oa
-e?iii?ioa?ae?a a ne?iaaooe? e?ia?, ia?aaaaeii o ?ia?oiee?a iniiaieo
i?ioan?e.

Aeyaeaii, ui a?oiith ?eceeo ?icaeoeo caoai?thaaiue ia/?iee ? iieiae?
?ia?oieee (20-30 ?ie?a) oa iniae c iaaaeeeei i?aecaiiei noaaeai (aei 5
?ie?a), ye? iaea?eueo noeeuei? aei ae?? oe?aeeeaeo /eiiee?a aeeaiei?
aoa?eueii? oaooe.

Aia?oa aeyaeaii cia/ia cieaeaiiy ??aiy ai?iiio oeiona a1-oeiiceio o
a??iee?a aeeaieeo aoa?eueieo oaoo.

Aecia/aii, ui a ?icaeoeo ?ioiiaeao?oeeoiiai noaio o a??iee?a aa?a
o/anoue aeao?oeeo ai?iiio oeiona – a1-oeiiceio.

Anoaiiaeaii, ui oaeoi?aie ?eceeo ?icaeoeo caoai?thaaiue ie?ie ? cia/i?
ii?ooaiiy aiaeii-nieueiaiai iai?io, ye? noi?iaiaeaeothoueny ci?iith
aeoeaiino? ?AAN, aacii?aneio ieacie e?ia?, neioaco i?inoaii?ae?a, ?
oeaio?aeueii? aaiiaeeiai?ee a caeaaeiino? a?ae aaaeeino? aeeiioaaieo
?ia?o, a?eo oa noaaeo ?iaioe.

Aecia/aii i?aeaeuaiiy ??aiy aiaeioae?io-1 a ieaci? e?ia? o a??iee?a a
caeaaeiino? a?ae aaaeeino? aeeiioaaieo ?ia?o.

Aia?oa cai?iiiiiaaia a?iioaca ?icaeoeo i?ioa?io??? iai?oaeaiiy o
a??iee?a aeeaieeo aoa?eueieo oaoo.

Aia?oa c’yniaai? iaoai?cie ?icaeoeo aaiaoo??? i?ney iaaaioaaeaiiy, yea
aeieea? i?e ci?i? ANI, i?aeaeuaii? aeoeaiino? ?AAN ? neioaco o?iiaienaio
a ie?eao, i?e iiaiiio ii?ooaii? aca?iica’yceo iii?ae aeine?aeaeoaaieie
?aaoeyoi?ieie nenoaiaie.

Aia?oa iieacai? oeueo?ano?oeoo?i? ?ic??ciaiiy a ?aaeoe?? ee?oei ia/?iee
oa i?ieneiaeueieo eaiaeueoe?a ie?ie ia ia?aa??aaiiy ? iaaaaeai?
aeaeo?iiii-i?e?ineii?/i? oa aeaeo?iiiia?noio?i?/i? e?eoa??? ?o
?ici?ciaaaiiy.

Aia?oa iieacaia aeeiai?ea ii?ooaiue IIE ? nenoaie aioeieneaeaioiiai
caoenoo, a oaeiae ?icaeoeo aoi?eiiiai ?ioiiaeao?oeeoiiai noaio a
caeaaeiino? a?ae aaaeeino? i?aoe? ? noaaeo ?iaioe a??iee?a oa ?o ?ieue a
?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

Cai?iiiiiaaia noaia iaoiaaiaco ?icaeoeo caoai?thaaiue ia/?iee o a??iee?a
aeeaieeo aoa?eueieo oaoo.

?ic?iaeai? oa ai?iaiaai? iia?, iaoiaaiaoe/ii iaa?oioiaai? iaoiaee
i?io?eaeoeee caoai?thaaiue ia/?iee oa ie?ie o a??iee?a, ye? iieyaathoue
o aeei?enoaii? i?aia?ao?a “Ni??oe?ia”, “Ai?cii” ? “Aio?aeue”.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe aeine?aeaeaiue
iiaeia oe?iei aeei?enoiaoaaoe a i?aeoeoe? ioi?iie caei?ia’y.

Ai?iaaaeaeaiiy eiiieaeniiai aeine?aeaeaiiy ooieoe?iiaeueiiai noaio
ia/?iee, na?oeaai-noaeeiii? oa na/iaeae?eueii? nenoai i?ae /an
i?io?eaeoe/ieo iaeyae?a a??iee?a aeeaieeo aoa?eueieo oaoo aeicaiey?
aeyaeoe a?oio ?ia?oiee?a c i?aeaeuaiei ?eceeii ?icaeoeo iaoieia?? oeeo
i?aai?a, ?ic?iaeoe i?ia?aio aeeniaina?iiai niinoa?aaeaiiy,
i?io?eaeoe/iiai e?eoaaiiy oa ?aoe?iiaeueiiai i?aoeaaeaoooaaiiy.

?aii? aeyaeaiiy ?ia?oiee?a c iiyaith i?ioa?io??? iai?oaeaiiy oa
iinoiaaaioaaeoaaeueii? aaiaoo??? ? ei?aeoe?y oeeo noai?a aeicaiey?
caiia?aoe ?icaeoeo caoai?thaaiue na/iaeae?eueii? nenoaie.

I?eaa?iaiiy oaaae e?ea??a aei caei?ia’y iieiaeeo a??iee?a (a?eii 20-30
?ie?a) oa ?ia?oiee?a c iaaaeeeei i?aecaiiei noaaeai (aei 5 ?ie?a), ye?
ua ia aaeaioiaai? aei oiia aeeaiei? aoa?eueii? oaooe, aeicaieeoue
cieceoe caoai?thaai?noue oa cia/ii i?aeaeueoe ?o i?aoeacaeaoi?noue.

Aeei?enoaiiy io?eiaieo aeaieo i?i ?ieue aeanoaa?e?caoe?? e?ciniiaeueieo
iaia?ai ye i?e/eie ?icaeoeo iae?ic?a a ee?oeiao ia/?iee ? ie?ie,
ii?ooaiiyo IIE, aioeieneaeaioii? nenoaie oa ?ioiiiai noaoono aeicaiey?
aeeth/eoe aei eiiieaeno i?io?eaeoe/ieo caoiae?a i?aia?aoe “Ni??oe?ia”,
“Aio?aeue” ? “Ai?cii”, ye? iathoue iaia?aiinoaa?e?coth/o,
aioeieneaeaioio oa ?ioiiiiaeoethth/o ae?th.

I?aeoe/ia canoinoaaiiy iiaiai niiniao ?aiiuei? i?io?eaeoeee
caoai?thaaiue ia/?iee ? ie?ie o i?aecaiieo a??iee?a aeeaieeo aoa?eueieo
oaoo oa ?aoe?iiaeueia i?aoeaaeaoooaaiiy caiia?aa? ?icaeoeo ii?ooaiue
ooieoe?iiaeueieo noai?a oeeo i?aai?a ? ni?ey? niia?eueiaiith oaii?a
?icaeoeo caoai?thaaiue (Iaoaio Oe?a?ie ?21063 A a?ae 04. 11. 97 ?. oa
Ooaaeueia ??oaiiy ia aeiao?ae ? 98010098/A a?ae 8.01.98 ?.).

Io?eiai? aeai? aeei?enoiaothoueny a eaeoe?eiiio eo?n? aeey nooaeaio?a,
e?ea??a-?ioa?i?a oa neooa/?a oaeoeueoaoo i?neyaeeieiiii? ina?oe
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ca ?acoeueoaoaie aeine?aeaeaiue i?aeaioiaeai? iaoiaee/i? ?aeiiaiaeaoe??.
Ioi?ieai? oa io?eiai? na?ae/aiiy ia 9 ?aoe?iiae?caoi?nueeeo i?iiiceoe?e.

Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeai? a i?aeoe/io
?iaioo Eoaainueei? iaeanii? ee?i?/ii? e?ea?i?, Aeiiaoeueeiai iaeaniiai
ee?i?/iiai oa?eoi??aeueiiai iaaee/iiai ia’?aeiaiiy, iaaeeei-nai?oa?ieo
/anoei i.E?aniiaeii, i.Noaoaiia, i.Ae/aanuee, i.E?aniee Eo/,
i.Aio?aoeeo, i.Iao?ianueea, i.Naa?aeeianuee, i.?iaaiueee.

Iniaenoee aianie caeiaoaa/a. Aaoi?o iaeaaeeoue aea?? oaie, aecia/aiiy
aaeaeaaoii? iaoe ? caaaeaiue aeine?aeaeaiiy, iaoiaeieia?/ieo iniia ??
aeeiiaiiy. Aeena?oaioii naiino?eii i?iaiaeeeenue ?aae?i?ioiieia?/i?
aeine?aeaeaiiy aeoeaiino? ?ai?io ieacie e?ia?, ??aiy aeueaeinoa?iio a
e?ia? oa na/?, ??aiy aacii?aneio oa aiaeioae?io-1 a ieaci? e?ia?, ??ai?a
o?iiaienaio A2 ? i?inoaoeeee?io a na/?, ??aiy i?inoaaeaiaeeio F2 a na/?,
aeine?aeaeaiiy aaiiaeeiai?ee, a oaeiae i?aeaioiaea iaoa??aeo a?ieia?/ieo
??aeei aeey aecia/aiiy aeaeo?ie?o?a ? e?aaoei?io, iieaciee?a IIE,
?ioiiiai noaoono, oa?iaio?a aioeia?aeeniiai caoenoo, aecia/aiiy yeeo
i?iaiaeeeiny o a?aeiia?aeieo eaai?aoi??yo. Caeiaoaa/ai naiino?eii
i?iaaaeaii aenia?eiaioaeueia aeine?aeaeaiiy. Aaoi?ii aoei i?iaiae?ciaaii
io?eiai? ?acoeueoaoe ca aeiiiiiaith eiii’thoa?ii? i?ia?aie, yeo a?i
naiino?eii aaeaiooaaa aeey i?iaaaeaiiy oe??? ?iaioe. Aaoi?ii naiino?eii
i?iaiaeeany aea?? i?aia?ao?a aeey ei?aeoe?? aeyaeaieo ci?i oa ?ic?iaea
noai ?o canoinoaaiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeeny ia IX i?aeia?iaeiiio eieiea?oi? AN?AI ii iao?ieia??
(Naoe, Ei?ay, 1992), onoaiia/?e eiioa?aioe?? iaoeiaiai oiaa?enoaa
iao?ieia?a ?in?? (Iineaa, 1992), III ?aa?iiaeuei?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? iieiaeeo a/aieo “Yeieiaey i?iiuoeaiiiai ?aaeiia Aeiiaanna”
(Eoaainuee, 1993), III i?aeia?iaei?e eiioa?aioe?? c i?aaaioeaii?
ea?ae?ieia?? (Inei, Ii?aaa?y, 1993), XIII i?aeia?iaeiiio iao?ieia?/iiio
eiia?an? (Iaae?eae, ?niai?y, 1995), ?aa?iiaeuei?e eiioa?aioe?? “I?iaeaiu
iaia?aiiie iaoieiaee a iaaeeoeeia” (Aeiiaoeuee, 1995), neiiic?oi?
“Oeceieiaey ii/ee e aiaeii-nieaaiai iaiaia” (Iiainea??nuee, 1995),
?aa?iiaeuei?e eiioa?aioe?? “I?iaeaiu iaia?aiiie iaoieiaee a iaaeeoeeia”
(Aeiai?iiao?ianuee, 1995), anana?oi?e eiioa?aioe?? ii eiio?ieth ca
a?ia?oaic??th (Iooaaa, Eaiaaea, 1995), ?anioae?eainuee?e eiioa?aioe??
“Ia?aeiiee i??eiiao?eo. ?ioa?noeoe?aeueiee iao?eo” (Oa?iii?eue, 1995),
III Naieo-Iaoa?ao?cueeiio nai?ia?? (Naieo-Iaoa?ao?a, 1995),
?aa?iiaeuei?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Nia?aiaiiua oaoiieiaee:
iienee, i?iaeaiu e iooe iiauoaiey yooaeoeaiinoe niaoeeaeece?iaaiiie
iaaeeoeeineie iiiiue ianaeaieth i?iiuoeaiiiai ?aaeiia” (Eoaainuee,
1995), XXXII i?aeia?iaeiiio eiia?an? ?a?iiaenei? Ie?eiai? Anioe?aoe??
(Ao?ie, A?aoe?y, 1995), ?aa?iiaeuei?e eiioa?aioe?? “100-eaoea iniiaaiey
4-e ai?iaeneie aieueieoeu” (Eoaainuee, 1996), ?anioae?eainuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “?ieue caaaeueiii?aeoeeoth/iai e?ea?y o
?ica’ycaii? i?iaeai i?io?eaeoeee ia?ioaeoe?eieo caoai?thaaiue” (Oa?e?a,
1997), Oino?e anaoe?a?inuee?e ia?aae? c ieoaiue iie?ee?i?/ii? ni?aae
(Euea?a, 1997), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeinyaiaiiy oa iaae??oai? ieoaiiy aano?iaioa?ieia??” (Oa?e?a, 1998), I
iaoe?iiaeueiiio eiia?an? Oe?a?ie ii ?ioiieia??, aea?aieia?? oa
?ioii?aaa?e?oaoe??. (Aeoooa, E?ei, 1998), XIV c’?cae? oa?aiaao?a Oe?a?ie
(Ee?a, 1998).

Aeena?oaoe?y aoea ai?iaiaaia ia ni?eueiiio can?aeaii? oanoe eaoaae?
oa?ai??, eaoaae?e caaaeueii? a?a??ie oa aeieia?? ? eaoaae?e
i?e?ia?ieia?? Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 40 ?ia?o, a oiio
/ene? 1 iiiia?ao?y, 8 aeaa o iiiia?ao?yo oa 17 noaoae o ia??iaee/ieo
aeo?iaeao. Cai?iiiiiaai? 2 niiniae i?io?eaeoeee ?ioiiaeao?oeeoiiai noaio
(Iaoaio Oe?a?ie ?21063 A a?ae 4. 11. 97 ?., oa Ooaaeueia ??oaiiy ia
aeiao?ae ? 98010098/A a?ae 8.01.98 ?.).

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 355
noi??ieao ae?oeiaaiiai oaenoo ? neeaaea?oueny ?c anooio, 4 ?icae?e?a
(iaeyae e?oa?aoo?e, aea? aeaae iniaenoeo aeine?aeaeaiue oa iaaiai?aiiy),
aeniiae?a, nieneo aeei?enoaieo aeaea?ae oa aeiaeaoe?a. ?iaioa ia? 52
iaethiea ? 29 oaaeeoeue. Nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae
aeeth/a? 599 iaeiaioaaiue.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeine?aeaeaiiy i?iaiaeeeenue ia
oaoo? “Iieiaeiaaa?ae?enueea” AeOE “E?aniiaeiiaoa?eey” ? oaoo? “I?eaii?”
AeOE “Eoaainueeaoa?eey”. Iaeaea? oaooe ? oeiiaeie aoaeaaeiaoaieie
i?aei?e?inoaaie Aeiiaano. Anueiai ianoaaeaii 1600 i?aecaiieo a??iee?a, c
yeeo aoei a?ae?a?aii 238 i?aeoe/ii caei?iaeo i?aecaiieo ?ia?oieea c
iaaaoeaiith ?aaeoe??th ia HBsAg. 90% ianoaaeaieo neeaaeaee iniae a?eii
a?ae 20 aei 50 ?ie?a. A?eueo?noue ianoaaeaieo (70%) iaee i?aecaiiee
noaae ?iaioe a?ae 5 aei 20 ?ie?a. ?ia?oieee oae caaieo “iniiaieo”
oaooa?nueeeo i?ioan?e (A?AC, i?io?aeieee), ye? aeeiiothoue aaaeeo ?iaioo
a iaeiani?eyoeea?oeo oiiaao i?aecaiiiai i?e?iee?iaoo neeaee 125 /ieia?e,
aai 54% a?ae caaaeueii? e?eueeino? ianoaaeaieo.

An? ianoaaeai? aoee ?iciiae?eai? ia a?oie: I – an? ianoaaeai? a??ieee;
II – iniae, ui i?aoethaaee a iaeiani?eyoeea?oeo i?aecaiieo oiiaao oa
aeeiioaaee ?iaioe aaeeei? aaaeeino?; III – iniae, ye? aeeiioaaee ?iaioe
na?aaeiuei? aaaeeino?; IY – iniae, a yeeo c’yaeyeanue i?ioa?io??y i?ney
?iai/i? ci?ie (aeueaoi?io??y 0,1-0,2 a/e); Y – iniae, a yeeo c’yaeyeanue
i?e?iaaiaoo??y i?ney ?iai/i? ci?ie (a?eo?ioeeoe a na/? 5-15·106/e).
Eiio?ieueio a?oio neeaee 80 caei?iaeo in?a. Aeey anoaiiaeaiiy aieeao
a?eo oa noaaeo ?iaioe a i?aecaiieo oiiaao ia aeine?aeaeoaai? iieacieee
on? ianoaaeai? aoee ?iciiae?eai? ia a?oie ca a?eii: 20-30 ?ie?a; 31-40
?ie?a; 41-50 ?ie?a oa 51-60 ?ie?a; oa ca noaaeai: aei 5 ?ie?a ; 5-10
?ie?a; 11-15 ?ie?a;16-20 ?ie?a oa 21-25 ?ie?a.

Aeine?aeaeaiiy a?e??oa?io, caaaeueiiai a?eeo, aeueaoi?i?a, aeiaoe?i?a,
oieanoa?eio, ?-e?iii?ioa?ae?a, oeiieiai? i?iae, aeai?iiai?
ai?iio?ainoa?ace (AeAO) oa ania?aa?iiai? ai?iio?ainoa?ace (AnAO) o
ieaci? e?ia? i?iaiaeeeinue ca caaaeueiii?eeiyoeie iaoiaeeeaie
(A.A.Ia?aaea??e, 1993).

Aea/aiiy noaio oeaio?aeueii? aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii
oao?aiiey?ii? ?aia?ao?? (O.N.Aeiia?aaeiaa, 1986; I.N.Eooaeianeee, 1995).
?a?no?aoe?th ?aiieaoeciia?ai aeeiioaaee ca aeiiiiiaith ?aia?aoa “?IA
2-02” oa ?a?no?aoe?eiiai i?eno?ith “Cardimax FX-326U (Fukuda Denshi,
ssiii?y).

I?e aeine?aeaeaii? noaio ANI oa ?AAN a??ieee aoee ianoaaeai? aea?/?:
aei oa i?ney ?iai/i? ci?ie (aacaeueiee oa noeioeueiaaiee ia??iaee
a?aeiia?aeii). O an?o ianoaaeaieo aecia/aany ai?no aeaeo?ie?o?a ?
e?aaoei?io a ne?iaaooe? e?ia? oa na/? (ca cae/aeieie iaoiaeeeaie), a
oaeiae aeoeai?noue ?ai?io ieacie (A?I), ??aaiue aeueaeinoa?iio a ieaci?
e?ia? (?A), ??aaiue aene?aoe?? aeueaeinoa?iio c na/ath (UA), ??aaiue
aacii?aneio (Vas) a ieaci? e?ia?, ??aaiue neioaco a ie?eao o?iiaienaio
OoA2 (ii aene?aoe?? iaoaaie?oo OoA2), i?inoaoeeee?io PgI2 (ii aene?aoe??
iaoaaie?oo 6-eaoiPgF1), i?inoaaeaiaeeio PgF2 aea/aany ca aeiiiiiaith
iaai??a ?aaeoea?a ?aae?i?ioiieia?/iei iaoiaeii (B.M.Jaffe, 1979):
“SB-REN-2”, “SB-ALDO-2” (ae?iaieoeoaa o??ie CIS, O?aioe?y),
“VASOPRESSIN-RAPID” (Buhlman Lab. AG, Oaaeoea??y), “6-eaoiPgF1”, “PgF2”
? “OoA2” (?inoeooo ?cioii?a Oai?nueei? aeaaeai?? iaoe). ?aae?iiao??th
c?ace?a ? inoaoi/iee ?ic?aooiie cae?enithaaee ia onoaiiaoe? “AAIIA-12” a
aaoiiaoe/iiio ?aaeei? ca niaoe?aeueiith i?ia?aiith EN-8072019.

Ai?no aiaeioae?io-1 (A-1) a ieaci? e?ia? aecia/aany ?ioiioa?iaioiei
iaoiaeii c aeei?enoaiiyi noaiaea?oieo iaai??a “The Biotrak TM
endotelin-1 ELISA system” o??ie Amersham ca?aeii ?aeiiaiaeaoe?e o
i?ioieie?. I?e i?iaaaeaii? ?ioiioethi?anoeaioiiai aiae?co
aeei?enoiaoaaee niaeo?ioioiiao? PR-2100 (O?aioe?y).

Iaoa??aeii aeey aenia?eiaioaeueiiai aeine?aeaeaiiy aoee 85 a?eeo uo??a,
yeeo ?ici?uoaaee a oaieia?e eaia?? c oaiia?aoo?ith iia?o?y 45iN oa
a?aeiiniith aieia?noth 65%. Eiio?ieueio a?oio neeaee 10 oaa?ei. An?
oaa?eie caciaee ii?oieia?/iiai aeine?aeaeaiiy, yea aeeth/aei na?oeiao
i?e?ineii?th, aeaeo?iiio i?e?ineii?th (“JEM-7A”, ssiii?y), e?euee?nia
ii?oiiao?e/ia (A.A.Aaoaiae?eia, 1984), oa aeaeo?iiiia?noio?i?/ia
aeine?aeaeaiiy eenei? oinoaoace (EO) – ia?ea?iiai oa?iaioo
e?ciniiaeueii-aaeoiey?iiai aia?aoo ee?oei (A.ss.Ieioe?i, 1992).

?ioaineai?noue i?ioean?a IIE aecia/aeanue ii ai?noo a ieaci? e?ia?
ae??iiaeo eii’thaao?a (AeE) ? iaeiiiaiai ae?aeueaeaa?aeo (IAeA).
Aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie – noia?ieneaeaeeniooace
(NIAe) a a?eo?ioeeoao e?ia? ? eaoaeace (EO) a ne?iaaooe? e?ia?
aeyaeyeany niaeo?ioioiiao?e/iei iaoiaeii ca oa?aeoa?iei iaeneioiai
iiaeeiaiiy a oeueo?ao?ieaoiaiio niaeo?? (?.A.Iaea?aiei, 1988;
I.A.Ei?iethe, 1988).

Aecia/aiiy O-e?ioioeeo?a, noaiiioeyoe?e O-oaeia?ia/?iaeoeoi??a ?
O-noi?ani??a/e?ea??a, A-e?ioioeeo?a cae?enithaaeinue c aeei?enoaiiyi
iaiae? iiiieeiiaeueieo aioeo?e CD3, CD4, CD8, CD22 (Orho Diagnostic
Systems Inc., NOA; A.I.O?ieia, 1989). ?ioiiaeiaoe?ie ne?iaaoee eean?a A,
I, G aecia/aee iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? (G.Mancini, 1965).

Aecia/aiiy ai?noo a ne?iaaooe? e?ia? a1-oeiiceio (a1O) i?iaiaeeeiny
?aae?i-?ioiieia?/iei iaoiaeii a eaai?aoi??? ?ioiia?ioaoiieia?? IAe?
oaoiieia?? e?iaicai?ithaa/?a oa ai?iiiaeueieo i?aia?ao?a, i. Iineaa.

Oa?/iaa aeiaaaea “Ni??oe?ia” i?ecia/aeanue 20 a??ieeai ii 1/2 /. e.
(1-1,25 a) o?e/? ia aeiao, i?ae /an ?ae?, i?ioyaii 10 aei?a. I?aia?ao
“Ai?cii” i?ecia/aany 18 a??ieeai ii 1 oaa. (0,25 a) – o?e/? ia aeiao
i?ioyaii 5 aei?a. I?aia?ao “Aio?aeue” i?ecia/aany 15 a??ieeai ii 1 oaa.
(0,2 a) o?e/? ia aeiao i?ioyaii 10 aei?a.

Iaea?aeai? aeai? ia?iaeyeeny ca aeiiiiiaith niaoe?aeueiiai iaeaoo
i?eeeaaeieo i?ia?ai ia AII IBM PC-486 AT.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aiae?c caoai?thaaiino? ia
oaoo? “I?eaii?” iieacaa, ui caoai?thaai?noue oai?iaaie ia/?iee oa
aeia/iaea?aeieo oeyo?a c?inoaea c 1993 ii 1996 ??e. Aei oiai ae, o 1996
?ioe? a?aeaoeiny iaeneiaeueia ca?eueoaiiy iieaciee?a: a aeiaaeeao ia 1,3
(92,8%) oa a aeiyo iai?aoeacaeaoiino? ia 38,2 (100,3%), i?e oeueiio,
caoai?thaai?noue neeaea 34 aeiaaeee oa 948 aei?a oei/aniai? ao?aoe
i?aoeacaeaoiino? oa iaeaea aaea?/? ia?aaeueea na?aaei? iieacieee ii
Eoaainuee?e iaeano?.

I?ney eiiieaeniiai i?io?eaeoe/iiai iaeyaeo 850 a??iee?a aoee a?ae?a?ai?
77 i?aeoe/ii caei?iaeo oaooa??a. Aiae?c nea?a a??iee?a iieacaa, ui
iaea?eueo ?iciianthaeaeaieie na?aae a??iee?a aoee: anoaiiaaaaoaoeaiee
neiae?ii (3,2%), aeeniaine/iee neiae?ii (2,9%), a?ae/oooy aaaeeino? oa
aie? a i?aaiio i?ae?aaa?’? (1,8%), aie? a noaeiaao (1,2%). I?e oeueiio o
21,5% a??iee?a ca aeaieie oeueo?acaoeiaiai aeine?aeaeaiiy aecia/ai?
??ciiiai?oi? ci?ie.

Aeey ooi/iaiiy oa?aeoa?o aeyaeaieo ci?i aoei ?icii/aoa a?io?i?/ia
aeine?aeaeaiiy e?ia? a??iee?a. Iieacieee aiae?coaaeenue a caeaaeiino?
a?ae aaaeeino? ?ia?o, a?eo oa noaaeo a??iee?a. Aeyaeeiny, ui ai?no
caaaeueiiai a?eeo a e?ia? a??iee?a neeaa 68,69-73,0 a/e. I?e ii??aiyii?
c eiio?ieueiith a?oiith (74,6±2,8 a/e), o ?ia?oiee?a ?? a?oie
anoaiiaeaii cieaeaiiy caaaeueiiai a?eeo a e?ia?. Ai?no aeueaoi?i?a o
?ia?oiee?a on?o a?oi aoa cia/ii ieae/ee, i?ae o eiio?ieuei?e a?oi?. I?e
oeueiio iaea?eueo iecueeee ??aaiue aeueaoi?i?a a e?ia? (37,16±1,8%, ui
a?aeiia?aeii aei 25,53±1,2 a/e) a?aecia/aiee o ?ia?oiee?a ?? a?oie.
Ni?aa?aeiioaiiy aeueaoi?i?a oa aeiaoe?i?a (A/A) o ?ia?oiee?a on?o a?oi
aoei o iaaeao a?ae 0,59±0,14 aei 0,69±0,11 oa cia/ii ieae/ei iieaciee?a
eiio?ieueii? a?oie. Anoaiiaeaia o oaooa??a a?iiaeueaoi?iai?y iiaea aooe
iia’ycaia c aaaeeith o?ce/iith i?aoeath a oiiaao a?ia?oa?i??, yea
aeeeeea? aaeeea niiaeeaaiiy a?eeo neaeaoiith ioneoeaoo?ith, aai
ii?ooaiiyi aeueaoi?ineioacoth/i? ooieoe?? ia/?iee (N.Ae. Iiaeuiiaa,
1995).

??aaiue oieanoa?eio o a??iee?a ? oa ?? a?oi ia?aaeuoaaa eiio?ieuei?
iieacieee. Ai?no a-e?iii?ioa?ae?a ?ia?oiee?a ?? a?oie aeyaeany aeuei ca
aeai? eiio?ieueii? a?oie. A?aei?/ai? ii?ooaiiy e?i?aeiiai iai?io
iaea?eueo ae?aaeai? o ?ia?oiee?a, ui aeeiiothoue aaaee? ?iaioe a
iaeiani?eyoeeaeo i?e?i-ee?iaoe/ieo oiiaao, iiaeeeai, aeieeee i?ae
aieeaii aaaeei? o?ce/ii? i?aoe? (I.A.No?i?ei, 1997). Iaeiae, ci?ie
e?i?aeiiai iai?io iiaee aooe ? aoi?eiieie, aiane?aeie a?iiaeueaoi?iai??
(A.A.*e?eei, 1994). E??i oiai, anoaiiaeai? o oaooa??a ci?ie e?i?aeiiai
iai?io iiaee ?icaeiooeny i?e ii?ooaiiyo a ia/?ioe?, aeeeeeaieo
ia?aa??aaiiyi (A.I.Iiaaaeueiiiay, 1994).

Ai?no AeAO o a??iee?a ?? a?oie aoa aeuee, i?ae o eiio?ieuei?e a?oi?.
Eiao?oe??io aea ??o?na (AnAO/AeAO) o oeeo ?ia?oiee?a neeaa 0,77±0,12, ui
oaeiae aoei ieae/a eiio?ieueieo iieaciee?a. I?aeaeuaiiy AeAO, cieaeaiiy
eiao?oe??ioo aea ??o?na o a??iee?a, ui aeeiiothoue aaaee? ?iaioe a
iaeiani?eyoeeaeo oiiaao i?aecaiieo ae?iaie, iiaea na?ae/eoe ia ei?enoue
oeeoie?co aaiaoioeeo?a (I.A.Aoaa?a?eoe, 1999), yeee iia’ycaiee c
ia?aa??aii (A.Iaaeiaa, 1993).

I?e ?iciiae?eaii? a??iee?a ia a?eia? a?oie aeyaeeinue, ui ai?no
caaaeueiiai a?eeo aoa iaeieae/ei o a??iee?a 20-30 ?ie?a. A oe?e aea
a?eia?e a?oi? ai?no aeueaoi?i?a aeyaeany iaeiaioei ? neeaa 35,77±1,92% ,
ui nooo?ai a?ae??ciyeinue a?ae ??aiy aeueaoi?i?a o oaooa??a 41-50 ?ie?a
(41,98±1,5%).

I?i?iaeueiee ??aaiue oieanoa?eio (4,44±0,37 iiieue/e) aecia/aany o
iieiaeeo ?ia?oiee?a, a iaeneiaeueiee (6,1±0,2 iiieue/e) – a noa?o?e
a?eia?e a?oi?, c a?aei?iaie iii?ae ieie. ??aaiue a-e?iii?ioa?ae?a oaeiae
ca?eueooaaany o a??iee?a noa?oi? a?eiai? a?oie o ii??aiyii? c iniaaie
20-30 ?ie?a. ??aaiue AnAO iaa iaea?eueoa cia/aiiy o a?eia?e a?oi? 20-30
?ie?a (0,22±0.05 iiieue/e a), oa cieaeoaaany aei 0,15±0,02 iiieue/e a a
a?oi? 51-60 ?ie?a.

Aiae?c ci?i a caeaaeiino? a?ae noaaeo ?iaioe iieacaa, ui ai?no
caaaeueiiai a?eeo aoa i?i?iaeueiei i?e noaae? ?iaioe aei 5 ?ie?a
(66,15±2,1 a/e) oa c?inoaa aei iaeneioio i?e noaae? 21-25 ?ie?a
(73,61±2,0 a/e). Ai?no aeueaoi?i?a aoa oaeiae iaeiaioei o ?ia?oiee?a c?
noaaeai aei 5 ?ie?a (34,55±2,8) oa aeyaeyany ieae/ei iieaciee?a
noaaeiaeo a?oi 16-20 oa 21-25 ?ie?a. A/A eiao?oe??io o oaooa??a c?
noaaeai aei 5 ?ie?a, 5-10 ?ie?a oa 11-15 ?ie?a aoa ieae/a, i?ae i?e
noaae? 16-20 oa 21-25 ?ie?a. Oe? ci?ie iiaeooue aooe iia’ycai? c oei, ui
i?aai?ci iieiaeeo ?ia?oiee?a ua ia anoea aaeaiooaaoeny aei aaaeeeo oiia
i?aoe?. ??aaiue a-e?iii?ioa?ae?a c?inoaa c i?i?ioio i?e noaae? aei 5
?ie?a (20,4±2,3 iae.) aei iaeneioio i?e noaae? 21-25 ?ie?a (26,1±3,12
iae.; ?

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