3

?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei

?i. A. I. Eii?na?aiea AII Oe?a?ie

IINAIEI Iaae?y Aeieo??aia

OAeE
612.822.43/.45.015.38:

612.6:616003.96

IAOAI?CIE AI?III-IAAe?AOI?IIAI ?II?EIOEIAO IAE?IAIAeIE?EIII?
?AAOEssOe?? ?AI?IAeOEOe??

OA NO?AN-?AAEOEAIINO?

14.01.14 aiaeie?eiieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a a?ieia?/ieo iaoe

Ee?a 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? aiaeie?eiieia?? oa
iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie

Iaoeiaee eiinoeueoaio

Aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio IAI oa AII
Oe?a?ie, caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie ?aci?eia Ieaenaiae?
A?eai?iae/, ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I.
Eii?na?aiea AII Oe?a?ie, caa?aeoaa/ a?aeae?eo aiaeie?eiieia??
?ai?iaeoeoe?? oa aaeaioaoe??

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe I?eioa Ieaen?e Noaiaiiae/, ?inoeooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie,
caa?aeoaa/ eaai?aoi??? ai?iiiaeueii? ?aaoeyoe?? iai?io ?a/iaei

aeieoi? a?ieia?/ieo iaoe, i?ioani? Eeiainueeee TH??e Iao?iae/, ?inoeooo
o?c?ieia?? ?i. I. I. Aiaiiieueoey IAI Oe?a?ie, caa?aeoaa/ a?aeae?eo
o?c?ieia?? noiaao?a iiceo

aeieoi? iaaee/ieo iaoe Oii?inueea C?ia?aea Ai?en?aia, ?inoeooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, caa?aeoth/a
eaai?aoi???th aiaeie?eiieia??

I?ia?aeia onoaiiaa

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo oa?iaeioa?ai?? aiaeie?eiieo
caoai?thaaiue IIC Oe?a?ie, i. Oa?e?a, eaai?aoi??y ?ai?iaeoeoeaii?
aiaeie?eiieia??

Caoeno a?aeaoaeaoueny 7 a?oaeiy 1999 ?. i 13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.558.01 c aiaeie?eiieia?? a ?inoeooo?
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a -114, aoe. Aeoai?iaenueea, 69)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a -114, aoe. Aeoai?iaenueea, 69)

Aaoi?aoa?ao ?ic?neaiee “4” eenoiiaaea 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? a?ieia?/ieo iaoe
E.I.Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aiiiae?? ?iaeea?aeoaeueiiai ?icaeoeo i?aai?cio ?
eiai ie?aieo o?c?ieia?/ieo nenoai, o oiio /ene? ?ai?iaeoeoeaii? oa
aaeaioaoe?eii?, iiaeooue aeieeaoe aiane?aeie iaoiaaiiiai aieeao
ai?iiiaeueiiai oa iae?io?aini?ooa?iiai aeenaaeaino, no?ano oa ?ioeo
/eiiee?a, ui aieeaathoue ia i?aai?ci, yeee ?icaeaa?oueny, oiaoi
aioo??oiueioo?iaii aai iaaaeiac? i?ney ia?iaeaeaiiy [G. Dorner et al.,
1976, 1983; A.I. Aaae/aa, 1981; B. Jarzab et al., 1990; A.A. Iaoiaiei e
ae?., 1990: A.A. Oaeyieia e ae?., 1995; A.A. ?acieeia, 1994, 1998]. Oea
i?ecaiaeeoue aei oi?ioaaiiy iaoieia?/ii? ?aaeoeaiino?, ii?ooaiiy
noaoaai? iiaaae?iee oa aacie?aeaey. Iaeiae ?ii?eioeiaia? iaoai?cie
?iaeea?aeoaeueiiai ?icaeoeo i?aai?cio oa ?o ?ieue o aeieeiaii?
ooieoe?iiaeueieo ?iceaae?a ?ai?iaeoeoeaii? ooieoe?? oa aaeaioaoe?eieo
i?ioean?a aiane?aeie no?ano oa ai?iiiaeueiiai aeenaaeaino a
ia?eiaoaeueiee ia??iae iioiaaiaco, caeeoathoueny iac’yniaaieie.

Inoaii?ie ?ieaie ana i/aaeaei?oei noa? oa, ui a nenoaio i?aai?caoe?eiiai
aieeao noaoaaeo noa?i?ae?a ia ia?aia? no?oeoo?e, ui ?icaeaathoueny,
caeo/athoueny iae?iiaae?aoi?e. Ia?aeii? ii?ooaiiy iae?i-iaae?aoi?ieo
nenoai aieiaiiai iiceo caeaoi? iiaeeo?eoaaoe aieea noaoaaeo noa?i?ae?a ?
ni?e/eieoe no?ee? ?iceaaee iae?iaiaeie?eiii? ?aaoeyoe?? aiiaaeio?iiii?
nae?aoe?? ? noaoaai? iiaaae?iee [P. Sickmoller et al., 1985; C. Wilson
et al., 1986; A.A. ?acieeia, A.I. Aeai/aiei, 1987; B. Jarzab et al.,
1990;]. ? iia?aeiieaiiy i?i iayai?noue iaae?aoi?ieo c?ooaiue, eio??
aeieeathoue ye a?aeaeaeai? iane?aeee ai?iiiaeueieo aieea?a ia iicie, ui
?icaeaa?oueny [I.Ae. Iinaiei e ae?., 1976; E.E. Na?iaa, A.*. Iae, 1986;
I.I. Aeuaaei, A.A. Iaoiaiei, 1988]. ?acii ?c oei, ?ieue
iae?iiaae?aoi?ieo nenoai o ?aiiueiio ai?iiiaeueiiio ?ii?eioeiao
aeine?aeaeaia ae?ae iaaeinoaoiuei. Na?aae iaae?aoi?ieo c?ooaiue,
i?e/aoieo aei ai?iii-iaae?aoi?iiai ?ii?eioeiao, ia?aaaaeathoue ci?ie
eaoaoieai?ia?a?/ii? nenoaie. I?ioa caeeoa?oueny aeeneon?eiei ieoaiiy i?i
?ieue eaoaoieai?i?a (EA) o iaoai?ci? ?aae?caoe?? ai?iiiaeueieo aieea?a
ia iicie, ui ?icaeaa?oueny. Aei e?ioey ia c’yniaaii, /e
iiina?aaeeiaothoue EA aieea noaoaaeo noa?i?ae?a, /e ae?thoue ?acii ?c
ai?iiiaie. ?nio? i?eiouaiiy, ui noaoaaa aeeoa?aioe?aoe?y
iae?iaiaeie?eiieo iaoai?ci?a ?aaoeyoe?? ?ai?iaeoeoeaii? ooieoe??
ni?yiiaaia ia oi?ioaaiiy iaaiiai naen-niaoeeo?/iiai oeio
iiiiai?ia?a?/ii? ?aaoeyoe?? aieiaiiai iiceo. O oie aea /an, iaoai?cie
oi?ioaaiiy noaoaaeo a?aei?iiinoae o iae?iiaae?aoi?ieo nenoaiao iiceo oa
?o no?oeoo?ia eieae?caoe?y caeeoathoueny iaaea/aieie.

Ooiaeaiaioaeueio iniiao noaoaai? aeeoa?aioe?aoe?? iiceo (NAeI)
noaiiaeoue iaoaaie?/ia o?ainoi?iaoe?y noaoaaeo ai?iii?a o
iae?iaiaeie?eiieo no?oeoo?ao, yea cae?enith?oueny ca aeiiiiiaith
a?iiaoaciiai oa?iaioiiai eiiieaeno. Iaeiae ieoaiiy i?i ?ieue ano?iaaiieo
iaoaaie?o?a o iaoai?ciao ai?iii-iaae?aoi?ii? aca?iiae?? a ia??iae NAeI
caeeoa?oueny iaeaea iaaeine?aeaeaiei. Caeeoa?oueny iac’yniaaiith ?ieue
ano?iaaiieo iaoaaie?o?a, cie?aia eaoaoieano?iaai?a (EA), ? EA ye
?iaeoeoi??a aeic??aaiiy iae?iaiaeie?eiii? nenoaie ?aaoeyoe??
?ai?iaeoeoeaii? ooieoe??.

O aaaaoueio aeiaaeeao ii?ooaiiy NAeI iiaeooue aeieeaoe aiane?aeie no?ano
aai ai?iiiaeueiiai aeenaaeaino a ia??iae i?aiaoaeueiiai iioiaaiaco.
A?aeaeaeaieie aoaeoaie i?aiaoaeueiiai no?ano o ethaeeie oa oaa?ei ?
aeaianeoe?i?caoe?y oa/aai oai?i?caoe?y noaoaai? iiaaae?iee o naioe?a [I.
Ward, 1972; 1984; F. Gotz, G. Dorner, 1980] ? ineaaeaiiy oa?oeeueiino? o
naiie [L. Herrenkohl, 1978]. O ?icaeoeo oeeo oaiiiai?a aaaeeeao ?ieue
a?ae?a?athoue ?iaeoeiaai? no?anii ci?ie EA, noaoaaeo ?
aetheiei?oeei?aeieo ai?iii?a iaoa?? ? ieiaea [I. Ward, J. Weisz, 1980;
W. Rohde et al., 1983, 1984; R. Salisburg et al., 1984]. ?acii ?c oei,
ia aea/aia ieoaiiy i?i aieea i?aiaoaeueiiai no?ano oa ?aiiueiai
ai?iiiaeueiiai aeenaaeaino ia oi?ioaaiiy noaoaaiai aeeii?o?cio
iiiiai?ia?a?/ii? nenoaie a aeene?aoieo no?oeoo?ao iiceo, ye? i?e/aoi?
aei ?aaoeyoe?? ?ai?iaeoeoe?? oa ai?iiiaeueieo i?ioean?a aaeaioaoe??, a
ia??iae ?aiiueiai iinoiaoaeueiiai iioiaaiaco.

Oi?ioaaiiy aaeaioaoe?eieo iaoai?ci?a oaeiae cia/iith i??ith caeaaeeoue
a?ae oeo aieea?a, ui ?o cacia? i?aai?ci o ia??iae aioo??oiueioo?iaiiai
?icaeoeo. ? iecea iia?aeiieaiue i?i ?iaeoeiaai? i?aiaoaeueiei no?anii
ii?ooaiiy ia?aa?ao caaaeueiiai aaeaioaoe?eiiai neiae?iio, yeee
noi?iaiaeaeo?oueny ci?iaie ?aaeoeaiino?
a?iioaeaii-a?iio?ca?ii-iaaeie?eiai? nenoaie (AAIN) [A.A. Iaoiaiei, I.I.
Aeuaaei, 1979; E. Naumenko, L. Maslova, 1985; A.A. Iaoiaiei e ae?.,
1990; M. Weinstock et al., 1992; L. Takahashi et al., 1992]. Aea
caaaeai?e i?iaeai? ia iaaeaii iaeaaeii? oaaae c oi/ee ci?o oi?ioaaiiy
noaoaaeo ? a?eiaeo iniaeeainoae no?an-?aaeoeaiino? AAIN o iauaaee?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioo aeeiiaii
a ?inoeooo? aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea AII
Oe?a?ie a ?aieao iaoeiai-aeine?aeieo i?ia?ai IIC oa AII Oe?a?ie (??
aea?ae?a?no?aoe?? 834a, 82a, NI.09.02.0002.85, 155, 182, 278), a oaeiae
iaoeiai-aeine?aeii? i?ia?aie, i?aeo?eiaii? AIIC oa a?aioaie
I?aeia?iaeiiai iaoeiaiai oiiaeo Aeae. Ni?ina (a?aioe UAP000, UAP200)

Iaoa ?iaioe aea/aiiy ?ii?eioeiaiaeo iaoai?ci?a iae?iaiaeie?eiii?
?aaoeyoe?? ?ai?iaeoeoeaii? ooieoe?? oa no?an-?aaeoeaiino? a ii?i? oa ??
iiaeeo?eaoe?e aiane?aeie no?aniaeo oa ai?iiiaeueieo aieea?a ia ie?ae ?
i?aai?ci iiaiia?iaeaeaiiai.

Iniiai? caaaeaiiy aeine?aeaeaiiy:

1. Aea/eoe ?ieue ooieoe?iiaeueiiai iaoaaie?cio oanoinoa?iio
(a?iiaoecaoe?? oa a?ae?ieneethaaiiy) o ?icaeoeo aiae?iaaiicaeaaeii?
iaoieia?? ?ai?iaeoeoeaii? nenoaie.

2. I?iaiae?coaaoe ?ieue ooieoe?iiaeueii? aca?iiae?? ano?iaaiieo
iaoaaie?o?a oa eaoaoieai?i?a ye ?iaeoeoi??a aeic??aaiiy
iae?iaiaeie?eiii? nenoaie ?aaoeyoe?? ?ai?iaeoeoe??.

3. Aeine?aeeoe i?ioean oi?ioaaiiy noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii?
nenoaie iiceo a ii?i? oa ca oiia ii?ooaiiy noaoaai? aeeoa?aioe?aoe??
iiceo aiane?aeie no?ano ? ai?iiiaeueiiai aeenaaeaino a i?a- oa
iinoiaoaeueiiio ia??iae? aeeooy.

4. Aea/eoe a?aeaeaeai? iane?aeee aieeao i?aiaoaeueiiai no?ano ia
iae?i-aiaeie?eiio ?aaoeyoe?th ?ai?iaeoeoeaii? ooieoe?? oa
no?an-?aaeoeaiino? a?iioaeaii-a?iio?ca?ii-iaaeie?eiai? nenoaie.

Iaoeiaa iiaecia ?acoeueoao?a aeine?aeaeaiiy. O aeena?oaoe?ei?e ?iaio?
aia?oa oai?aoe/ii oa aenia?eiaioaeueii iaa?oioiaaii iae?io?i?/io
eiioeaioe?th ai?iii-iaae?aoi?iiai ?ii?eioeiao iae?iaiaeie?eiii?
?aaoeyoe?? ?ai?iaeoeoe?? oa aaeaioaoe??. Aeiaaaeaii, ui i?ioeane
?ii?eioeiao o iiceo a?aeaoaathoueny oeyoii aca?iiae?? eaoaoieai?i?a,
noa?i?aeieo ai?iii?a oa ?o aeoeaieo iaoaaie?o?a (cie?aia,
eaoaoieano?iaai?a), ui ooai?ththoueny aaciina?aaeiuei a oeaieiao
oeaio?aeueii? ia?aiai? nenoaie (i?aiioe/i?e ae?eyioe?, iaae?iaacaeueiiio
a?iioa-eaion?), ca iaoai?ciii ei?iaeoeoe??.

Anoaiiaeaii, ui ii?ooaiiy ?ii?eioeiaiaeo iaoai?ci?a aiane?aeie
ia?eiaoaeueieo no?ani?ieo oa ai?iiiaeueieo aieea?a i?ecaiaeeoue aei
?icaeoeo ooieoe?iiaeueieo ?iceaae?a ?ai?iaeoeoeaii? nenoaie (
aiiaoeyoi?ia iaie?aei?noue) oa no?an-?aaeoeaiino? (neiae?ii
i?aiaoaeueiiai no?ano).

Aeyaeai? iia? iaoiaaiaoe/i? iaoai?cie iae?iaiaeie?eiii? iaoieia??,
coiiaeaii? no?aniaeie e ai?iiiaeueieie /eiieeaie a i?ioean? ?icaeoeo
ieiaea oa i?aai?cio a ia??iae ?aiiueiai iioiaaiaco. Aeiaaaeaii, ui ?aii?
iinoiaoaeuei? ci?ie iiiiai?ia?a?/ii? nenoaie iiceo, ui aeieeathoue
aiane?aeie i?aiaoaeueiiai no?ano oa ia?eiaoaeueiiai ai?iiiaeueiiai
aeenaaeaino, caeo/ai? aei ?ii?eioeiaiaeo iaoai?ci?a ? aeaoa?i?iothoue
a?aeaeaeai? ci?ie iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe?? oa
no?an-?aaeoeaiino? AAIN. Ii?oieia?/iei i?iyaii ooieoe?iiaeueieo
ii?ooaiue ? cieeiaiiy noaoaaeo a?aei?iiinoae uiaei ia’?io yaea?
iae?ioeeo?a o naen-aeeii?oieo ae?eyieao iiceo, cie?aia a
noi?ao?aciaoe/iiio yae?? a?iioaeaiona. Anoaiiaeaii, ui aetheiei?oeei?aee
? iiaeeeaeie ai?iiiaeueieie /eiieeaie, ye? iiina?aaeeiaothoue iaoiaaiiee
aieea no?ano i?ae /an aaa?oiino? ia ?icaeoie iae?iaiaeie?eiii? nenoaie o
iauaaee?a.

Aeiaaaeaii, ui eaoaoieai?ie a?iioaeaiona ? o??th ni?eueiith eaieith a
iaoiaaiac? ii?ooaiue noaoaai? aeeoa?aioe?aoe?? iiceo, ye? aeieeathoue ye
aiane?aeie no?ani?ieo aieea?a o ia??iae aioo??oiueioo?iaiiai ?icaeoeo
i?aai?cio, oae ? ai?iiiaeueiiai aeenaaeaino o iiaiia?iaeaeaieo oaa?ei.

Aia?oa aea/aii iioiaaiaoe/iee i?io?eue (a?ae noaoaaic??eiai a?eo aei
noa?ino?) ci?i no?an-?aaeoeaiino? AAIN o iauaaee?a iaio noaoae, ye?
caciaee aieeao no?ano o ia??iae aioo??oiueioo?iaiiai ?icaeoeo. Aeyaeaii
o?eaaeee oa?aeoa? oeeo ci?i, ye? caa??aathoueny iaa?oue o noa?eo oaa?ei
(neiae?ii i?aiaoaeueiiai no?ano). Aeiaaaeaii, ui i?aiaoaeueiee no?an
caeaoiee iiaeeo?eoaaoe ia?aa?a no?an-a?e-neiae?iio, oiaoi iaaiith i??ith
ci?ithaaoe i?ia?aio iioiaaiaco.

Anoaiiaeaii, ui aieea i?aiaoaeueiiai no?ano ia aaeaioeai? ?aaeoe?? AAIN
o aei?ineeo ? noa?eo oaa?ei ?aae?co?oueny ca ?aooiie iaoai?ci?a, ye?
caeaaeaoue a?ae noao?. Aeyaeaii, ui i?ae aieeaii i?aiaoaeueiiai no?ano
ai?iiiaeueia ?aaeoe?y ei?e iaaeie?eiaeo caeic o aei?ineeo naiie iii??ii
iineeth?oueny, a o naioe?a nooo?ai cieaeo?oueny. C’yniaaii, ui iniiaiith
iaoiaaiaoe/iith eaieith ineaaeaii? no?an-?aaeoeaiino? AAIN o aei?ineeo
i?aiaoaeueii no?aniaaieo naioe?a uo??a ? cia/ia ciaioaiiy aea?eueiaiiy
ii?aae?aiae?io a a?iioaeaion? o a?aeiia?aeue ia no?ania? noeioee.

Aeyaeaii, ui i?ae /an noa??iiy o i?aiaoaeueii no?aniaaieo naioe?a uo??a
caa??aa?oueny caeaoi?noue eaoaoieai?i?a a?iioaeaiona ?aaaoaaoe ia
no?ania? noeioee ia oe? cia/ii? aeoea?caoe?? ooieoe?? ei?e iaaeie?eiaeo
caeic. Aeiaaaeaii, ui i?ae aieeaii i?aiaoaeueiiai no?ano o noa?eo naiie
cieaeothoueny aaeaioeai? iiaeeeaino? eaoaoieai?iiai? nenoaie
a?iioaeaiona, i?ioa caa??aa?oueny aae?aiiei?oeeaeueia ?aaeoe?y ia
no?ania? noeioee, ui na?ae/eoue i?i a?eueo i?ci? caanaiiy aaeaioeaieo
iaoai?ci?a.

I?aeoe/ia cia/aiiy ?iaioe. Oai?aoe/i? iieiaeaiiy, ye? aeieeaathoue ?c
?acoeueoao?a i?iaaaeaii? ?iaioe, ni?eythoue ?icoe?aiith oa ?icaeoeo
i?iaeaie “O?c?ieia?/i? iaoai?cie ae?? ai?iii?a” ?, cie?aia, oaei? ??
/anoeie, ye “Ai?iiie oa iicie”. Iaea?aeai? ?acoeueoaoe ?ice?eaathoue
aaaeeeaa cia/aiiy ?ii?eioeiai-aeo iaoai?ci?a ?icaeoeo iae?iaiaeie?eiii?
iaoieia?? ?ai?iaeoeoe?? oa no?an-?aaeoeaiino?, yea aeieea? aiane?aeie
ia?eiaoaeueii? iiaeeo?eaoe?? i?ia?aie ?iaeea?aeoaeueiiai ?icaeoeo
i?aai?cio, ? aeathoue i?aenoaao cai?iiiioaaoe eiioeaiooaeueio iiaeaeue
ai?iii-iaae?aoi?iiai ?ii?eioeiao iae?iaiaeie?eiii? nenoaie. C iiceoe?e
oe??? eiioeaioe?? io?eiai? aeai? aeicaieythoue ii-iiaiio inieneeoe
caaaeuei? caeiiii??iino? iaoiaaiaco no?an-?aaeoeaiino? AAIN,
aiaeie?eiiiai aacie?aeaey, a oaeiae ii?ooaiue noaoaai? iiaaae?iee.

?acoeueoaoe aeine?aeaeaiue aeaiiino?othoue iioaioe?eio iaaaciaeo
aeiiieiaiaiai no?ano aeey ?ai?iaeoeoeaiiai caei?ia’y oa aaeaioaoe?eiiai
iioaioe?aeo o iauaaee?a ? iiaeooue neoaeeoe oai?aoe/iei iaa?oiooaaiiyi
aeey oe?eani?yiiaaiiai iiooeo cania?a ? iaoiae?a i?io?eaeoeee oa
ei?aeoe?? ii?ooaiue iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoeaii? oa
aaeaioaoe?eii? nenoai. Io?eiai? aeai? uiaei a?aeaeaeaieo iane?aee?a
aieeao no?ano, aetheiei?oeei?aeieo oa noaoaaeo ai?iii?a o ia??iaee
aioo??oiueioo?iaiiai oa ?aiiueiai iinoiaoaeueiiai ?icaeoeo i?aai?cio ia
iae?iaiaeie?eiio nenoaio iiaeooue aooe ei?eni? oe?ieiio eieo
ee?i?oeeno?a: aeooa?ai-a?iaeieiaai, iaae?ao?ai, naeniiaoieiaai oa
aa?iioieiaai. Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ a?aa
aaciina?aaeith o/anoue o ?ic?iaoe? i?ia?aie aeine?aeaeaiue oa aeeiiaii?
an?o aenia?eiaioaeueieo aeine?aeaeaiue, ?acoeueoaoe yeeo aeeeaaeai? a
aeena?oaoe??. Ii?oieia?/ia aeine?aeaeaiiy eaoaoieai?ia?a?/ieo oa?i?iaeae
na?aaeeiiiai ocaeooy i?iaaaeaii ca o/anoth e.a.i. E.O. Ao?/einueei?,
noa?oiai iaoeiaiai ni?a?ia?oieea ?inoeoooo o?c?ieia?? ?i. I.I.
Aiaiiieueoey IAI Oe?a?ie; ?aooa ii?oieia?/ieo aeine?aeaeaiue — ca
o/anoth ae.a.i. O.?. Aiaaeaiiai?, e.a.i. A.A. Eice?eoeueeiai oa
iaoeiaiai ni?a?ia?oieea E.?. Iieyeiai? ia aac? eaai?aoi??? ii?oieia??
aiaeie?eiii? nenoaie oa a?aeae?eo aiaeie?eiieia?? ?ai?iaeoeoe?? oa
aaeaioaoe?? ?inoeoooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I.
Eii?na?aiea AII Oe?a?ie.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue oa iaaiai?thaaeenue ia: I?aeia?iaeiiio neiiic?oi?,
i?enay/aiiio i?iaeaiai iae?iiioiaaiaco (I?aaa, 1985); ??? Ananithci?e
eiioa?aioe?? c i?iaeai iae?i-aiaeie?eiieia?? (Oa?e?a, 1988);
I?aeia?iaei?e eiioa?aioe?? c i?iaeai iae?i-aiaeie?eiieia?? (Othaeiaai,
1989); ??? I?aeia?iaei?e eiioa?aioe?? c i?iaeai naenieia?? (Aa?e?i,
1990); 5-e eiioa?aioe?? ?a?iiaenueeiai oiaa?enoaa iae?i-aiaeie?eiieia?a
(Aoaeaiaoo, 1991); Ananithciiio neiiic?oi? “Iae?ia?ieia?/i? aniaeoe
no/anii? aiaeie?eiieia??” (Iineaa, 1991); ?O I?aeia?iaeiiio eiia?an? c
ai?iiiaeueieo noa?i?ae?a (Aeaean, 1994); 3-io I?aeia?iaeiiio eiia?an? c
iae?i-aiaeie?eiieia?? (Aoaeaiaoo, 1994); O?O c’?cae? Oe?a?inueeiai
o?c?ieia?/iiai oiaa?enoaa ?i. ?.I. Iaaeiaa (Ee?a, 1994); ?O
Ana?in?enuee?e eiioa?aioe?? “Iae?i-aiaeie?eiieia?y-95” (Naieo-Iaoa?ao?a,
1995); ?? Iaoe?iiaeueiiio eiia?an? iaoi-o?c?ieia?a Oe?a?ie (Ee?a, 1996);
I?aeia?iaeiiio neiiic?oi? “Iae?iaiaeie?eii? aniaeoe ?ai?iaeoeoe??”
(Aa?oaaa, 1996); C’?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa
(Aeiiaoeuee, 1998). Aeena?oaoe?y i?ieoea ai?iaaoe?th ia ni?eueiiio
can?aeaii? ai?iaaoe?eii? eii?n?? c aenia?eiaioaeueii? aiaeie?eiieia?? oa
i?io?eueieo a?aeae?e?a ? eaai?aoi??e ?inoeoooo aiaeie?eiieia?? oa iai?io
?a/iaei ?i. A.I. Eii?na?aiea AII Oe?a?ie 4 /a?aiy 1999 ?.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 46 iaoeiaeo ?ia?o,
c yeeo 22 noaoo? o oaoiaeo iaoeiaeo aeaeaiiyo (6 iaeiiin?aieo ? 16 o
ni?aaaoi?noa?) ? 24 ioae?eaoe?? ca iaoa??aeaie i?aeia?iaeieo ?
a?o/eciyieo iaoeiaeo c’?cae?a, neiiic?oi?a, eiioa?aioe?e.

Ia’?i ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?th aeeeaaeaii ia 293
noi??ieao ae?oeiaaiiai oaenoo. ?iaioa neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iaoiaee/iiai ?icae?eo, i’yoe ?icae?e?a aeanieo
aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a, aeniiae?a oa nieneo
e?oa?aoo?e, yeee i?noeoue 570 aeaea?ae. ?iaioo ?ethno?iaaii 35
oaaeeoeyie oa 13 ?enoieaie.

CI?NO ?IAIOE

Iaoa??aee, iaoiaee oa iiaeae? aeine?aeaeaiue

Oaa?eie. Aeine?aeaeaiiy i?iaaaeai? ia 3000 naioeyo ? naieao uo??a e?i??
A?noa? ??ciiai a?eo c aeaoiaaiei aeiai ia?iaeaeaiiy: iiaiia?iaeaeaieo ?
?aiiueiai iinoiaoaeueiiai a?eo (1- 7, 8, 10 ? 12 -aeaiieo),
noaoaaic??eeo (3-6-i?ny/ieo) ? noa?eo (20-22-i?ny/ieo). Aeaiue
ia?iaeaeaiiy iauaaee?a aaaaeaee ca ia?oo aeiao aeeooy. Oaa?ei
oo?eioaaee i?e e?iiaoi?e oaiia?aoo?? oa i?e?iaeiueiio oioiia??iae?. An?
oaa?eie ciaoiaeeeeny ia cae/aeiiio ?aoe?ii? a?aa??th. Aaaaeaiiy
ai?iiiaeueieo oa ?ioeo i?aia?ao?a, no?anoaaiiy, a oaeiae caa?e oaa?ei
cae?enithaaee a iaeei ? oie aea /an aeiae i?ae 10 oa 11 aiaeeiaie ?aieo
aei i?eeiaiiy ?aee. Aenia?eiaioe noaaeee ia?aaaaeii o ceiiai-aaniyiee
ia??iae (ethoee-ea?oaiue). Eiaeia aeine?aeia a?oia oaa?ei aea/aeany
iaeii/anii c a?aeiia?aeiith eiio?ieueiith a?oiith. Oaa?ei caaeaaee
oaeaeeith aeaeai?oaoe??th ca?aeii c oiiaaie aenia?eiaio?a.

Ai?iiiaeuei? i?aia?aoe. Oanoinoa?ii-i?ii?iiao (5% ?ic/ei aeey
aioo??oiueii’yciaeo ?i’?eoe?e a aiioeao), ?ic/eiaiee o e?noi/eia?e aai
neeaia?e ie??, aaiaeeee naieai uo??a i?ae oe??o iaeii?aciai a aeic? 50
iea ia oaa?eio ia ia?oo aai i’yoo aeiao aeeooy, aai a aeic? 250 iea ia
o?ao?e aeaiue aeeooy a ia’?i? 40 iee. Caa?e oaa?ei i?iaiaeeee ia 7, 8,
10 ? 12-oo aeiao aeeooy, a oaeiae o 3-4-i?ny/iiio a?oe?.

2-A?ae?ieneano?ii (2-IIA1), 2-a?ae?ieneano?aae?ie-17 (2-IIA2-17)
(“Steraloids”, NOA), 4-a?ae?ieneano?aae?ie-17 (4-IIA2-17), a oaeiae
4-a?ae?iene-ano?aae?ie-17 (4-IIA2-17) (inoaii? aeaa i?aia?aoe etha’ycii
iaaeai? i?io. R. Knuppen, I?ia//eia) ?ic/eiyee o i?ii?eaiae?eie? c 0,01%
anei?a?iiai? eeneioe ? aaiaeeee naieai uo??a i?ae oe??o iaeii?aciai aai
aaaaoi?aciai a aeic? 5, 10 aai 25 iea ia oaa?eio a ia’?i? 40-100 iee ia
i?ioyc? ?aiiueiai iinoiaoaeueiiai ia??iaeo ?icaeoeo. A ie?aieo
aeine?aeao 5-aeaiiei naieai uo??a i?iaiaeeee i?yi? ?io?aoea?aa?aeuei?
?i’aeoe?? 2-IIA1 ? 2-IIA2-17 a aeic? 5 iea ia oaa?eio a ia’?i? 10 iee
ca iaoiaeii N. Hasegawa et al. (1991). Eiio?ieuei? oaa?eie aiaeia?/iei
/eiii (nenoaiii aai ?io?aoea?aa?aeueii) io?eioaaee aea?aaeaioio
e?euee?noue ?ic/eiieea aeine?aeaeoaaieo i?aia?ao?a. A caeaaeiino? a?ae
iio?aa aenia?eiaioo oaa?ei aeaeai?ooaaee /a?ac 30 oa, 1, 2, 3, 4 oa
24 aiae, a oaeiae /a?ac 2, 5 oa 7 ae?a i?ney inoaiiuei? ?i’?eoe??
a?aeiia?aeiiai i?aia?aoo. ?aooo oaa?ei aeaeai?ooaaee o 3-4-i?ny/iiio
a?oe?.

A?ae?iei?oecii aoeaoao (“Aaaeaii ?eooa?”, Oai?ueia) o aeic? 50 ia/ea
iane o?ea aaiaeeee naieai uo??a i?ae oe??o uiaeaiii ia i?ioyc?
inoaiiueiai oeaeiy aaa?oiino?, oiaoi c 15-i? ii 21-oo aeiao. Iauaaee?a
uo??a iaio noaoae aeaeai?ooaaee ia 10-oo aeiao i?ney ia?iaeaeaiiy aai o
3-4-i?ny/iiio a?oe?.

Oa?iaeieia?/i? i?aia?aoe. ?ia?a?oi?e a?iiaoace oanoinoa?iio
aiae?ino-4-?i-3,6,17-o??ii (AO) o aeic? 0,5 ia ia oaa?eio oa
aiae?ino-1,4,6-o???i-3-17-ae?ii (AOAe) (“Steraloids”, NOA) o aeic? 1 ia
aai 0,1 ia aaiaeeee naieai uo??a iiiaeeioe? aai ?acii c OI ia i?ioyc?
ia?oeo ae?a i?ney ia?iaeaeaiiy. Caa?e oaa?ei i?iaiaeeee ia 7, 8, 10 oa
12-o aeiao iinoiaoaeueiiai ?icaeoeo, a oaeiae o 3-i?ny/iiio a?oe?.

?ia?a?oi? eaoaoie-I-iaoeeo?ainoa?ace o?iiieii (“Sigma“, NOA) ?ic/eiyee a
caaooa?aiiio o?c?ieia?/iiio ?ic/ei? (?I 6,5) ? aaiaeeee naieai uo??a o
aeicao 100, 300 aai 600 iea ia oaa?eio o ??ciee oa?i?i ?aiiueiai
iinoiaoaeueiiai ia??iaeo aeeooy iiiaeeioe? aai ?acii ?c OI aai
2-IIA2-17. Oaa?ei aeaeai?ooaaee /a?ac 3, 6 oa 24 aiae i?ney inoaiiuei?
?i’?eoe?? i?aia?aoo, a oaeiae ia 10-o aeiao iinoiaoaeueiiai ?icaeoeo. A
ie?aieo aeine?aeao oaa?ei aeaeai?ooaaee o 3-i?ny/iiio a?oe?.

Iiia?aaeiee eaoaoieai?i?a L-AeIOA ( L—(3,4-aeea?ae?ieneoai?e)-aeai?i;
“Koch-Light“, Aiae?y) ?ic/eiyee o i?aeeeneaiiio 1i nieyiith eeneioith
o?c?ieia?/iiio ?ic/ei? ? aaiaeeee naieai uo??a o aeic? 1 ia ia
oaa?eio c 4-i? ii 10-o aeiae aai o aeic? 0,2 ia ia 5-o oa 7-o aeiao
aeeooy. Eiio?ieuei? oaa?eie iaea?aeoaaee ?ic/eiiee i?aia?aoo. Caa?e
oaa?ei i?iaiaeeee o 3-i?ny/iiio a?oe?.

6-A?ae?ieneaeioai?i a?ae?ioei?eae (6-II-AeA) (“Serva”, I?ia//eia)
?ic/eiyee o o?c?ieia?/iiio ?ic/ei? c 0,1% anei?a?iiai? eeneioe ?
aaiaeeee naieai uo??a o aeic? 1 ia ia oaa?eio (100 ia/ea iane o?ea) ia
i?ioyc? ia?oeo aeaio ae?a i?ney ia?iaeaeaiiy. Oaa?ei aeaeai?ooaaee o
10-aeaiiiio oa 3-i?ny/iiio a?oe?.

On? oa?iaeieia?/i? i?aia?aoe aaiaeeee iiaiia?iaeaeaiei oaa?eiai i?ae
oe??o a ia’?i? 40 iee.

I?aiaoaeueiee no?an. A iniiao aenia?eiaioaeueii? iiaeae? i?aiaoaeueiiai
no?ano iieeaaeaii oaeo, yea aoea cai?iiiiiaaia I. Ward, J. Weisz
(1984). Naiie o noaae?? ano?ono i?aenaaeaeoaaee aei noaoaaic??eeo
naioe?a (ii aea? naiee ia naioey). Aeniiaie i?i ianoaiiy aaa?oiino?
?iaeee ia i?aenoaa? aeyaeaiiy nia?iaoici?ae?a o aaa?iaeueieo iaceao
ianooiiiai ?aieo. *anoeia naiie c 15-i? ii 21-oo aeiao aaa?oiino?
i?aeaeaaaeanue uiaeaiiiio no?anoaaiith oeyoii ?iiia?e?caoe?? ia niei?
i?ioyaii 1 aiae. Iano?aniaai? aaa?oi? naiee neeaaeaee eiio?ieueio
a?oio.

A?io?i?/i? iaoiaee. Ai?no ii?aae?aiae?io (IA) oa aeioai?io (AeA)
aecia/aee a no?oeoo?ao aieiaiiai iiceo (oe?eiio a?iioaeaion?,
i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion?) oeoi?eiao?e/iei
iaoiaeii [D. Jacobowitz, J. Richardson, 1978]. I?aiioe/io ae?eyieo oa
iaae?iaacaeueiee a?iioaeaion iiaiia?iaeaeaieo uo??a aeae?eyee i?ae
noa?aii?e?ineiiii ca iaoiaeii V. Luine et al. (1975) ia oieiaeo i?e + 4
0 N. C?acee aeine?aeaeoaaieo ae?eyiie iiceo ia’?aeioaaee a?ae 3-4
uo?aiyo a?aeiia?aeii? noao?. Ca noaiaea?oe aeei?enoiaoaaee
L-ii?aae?aiae?i a?oa?o?ao oa nieyiieeneee 3-a?ae?ieneoe?ai?i
(“Koch-Light”, Aiae?y). Oethi?anoeaioe?th aei??thaaee ia
niaeo?ioethi?eiao?? “O?oa/? MPF-2A” (ssiii?y).

Ia?a IA ? AeA o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion?
iiaiia?iaeaeaieo uo??a aeine?aeaeoaaee ca aeiiiiiaith ?ia?a?oi?a
oe?iceia?ae?ieneeace -iaoee-ia?a-oe?iceio (IIO; “Sigma”, NOA), yeee
aaiaeeee iaeii?aciai i?ae oe??o o aeic? 250 iea a?eueii? iniiae ia 1 ea
iane o?ea ca iaeio aai aea? aiaeeie aei aeaeai?oaoe?? oaa?ei. Eiinoaioo
oaeaeeino? ia?ao, oaeaee?noue ia?ao oa /an ia?ao iiiiai?i?a
?ic?aoiaoaaee ca iaoiaeii B. Brodie et al. (1966) ia i?aenoaa?
aecia/aiiy ai?noo iiiiai?i?a aei oa i?ney aaaaeaiiy IIO.

Ai?no na?ioii?io (NO) oa 5-a?ae?iene?iaeieioeoiai? eeneioe (5-A?IE) o
aeene?aoieo no?oeoo?ao iiceo aecia/aee iaoiaeii aenieiaoaeoeaii?
??aeeiii? o?iiaoia?ao?? i?ae aenieei oeneii ?c oethi?eiao?e/iei
aeaoaeoi?ii [A. Krstulovic, C. Matzura, 1972]. Iaoaaie?/iee ia?a
na?ioii?io ?ic?aoiaoaaee ii ni?aa?aeiioaiith eiioeaio?aoe?e eiai
iniiaiiai iaoaaie?oo 5-A?IE oa NO ( 5-A?IE/NO).

Aeoeai?noue eaoaoie-I-iaoeeo?ainoa?ace (EIIO) o a?iioaeaion? aecia/aee
o i?e?iniiaeuei?e o?aeoe?? ca iaoiaeii R. McCaman (1965) o iiaeeo?eaoe??
W. Ladosky, H. Schneider (1981). Ca noano?ao aeei?enoiaoaaee
3,4-aeea?ae?ieneaaicieio eeneioo (iaea?aeaia c
3,4-aeea?ae?ieneaaicieiiai aeueaeaa?aeo, E. Merck, a eaai?aoi???
i?aneioaco). Aeiiaoi?ii iaoeeueieo a?oi aoa
S-aaeaiicee-iaoee-[14C]-iaoeii?i (NEN Research Products, NOA). I?ney
cae?i/aiiy ?ieoaaoe?? i?e 27 0 N iaoeeueiaai? i?iaeoeoe aeno?aaoaaee
aoeeaoeaoaoii ? i?iaiaeeee ?aae?iiao??th aeno?aeo?a ia aaoa-niaeo?iiao??
“Beckman” (NOA). Ai?no a?eeo aecia/aee iaoiaeii O. Lowry et al.
(1951).

??aaiue ei?oeeinoa?iio (11-ieneei?oeeinoa?i?ae?a) o ieaci? e?ia?
aecia/aee oethi?eiao?e/iei iaoiaeii [P. De Moor et al., 1960], ai?no
oanoinoa?iio (O) ? ano?aae?ieo o ieaci? e?ia? ?ioiioa?iaioiei iaoiaeii
?c aeei?enoaiiyi noaiaea?oieo iaai??a Testosterone Kit ? Estradiol Kit
o??ie “Bio-Rad “(?oae?y).

No?an-?aaeoeai?noue AAIN o aei?ineeo (3-5-i?ny/ieo) oa noa?eo
(20-22-i?ny/ieo) ?ioaeoieo ? i?aiaoaeueii no?aniaaieo naioe?a ? naiie
uo??a aeine?aeaeoaaee ca ?aaeoe??th eaoaoieai?i?a a?iioaeaiona oa ei?e
iaaeie?eiaeo caeic ia aeiciaaiee ?iiia?e?caoe?eiee no?an. Uo??a eiaeii?
a?eiai? a?oie a?aeiia?aeii? noao? (?ioaeoi? oa i?aiaoaeueii no?aniaai?)
aoei i?aeaeaii ?iiia?e?caoe?? ia niei? i?ioyaii 30 aai 60 oa. Oaa?ei
caaeaaee oaeaeeith aeaeai?oaoe??th a?ae?aco i?ney cae?i/aiiy no?ano aai
/a?ac 30 oa i?ney cae?i/aiiy iaeiiaiaeeiiiai ?iiia?e?caoe?eiiai no?ano.
Eiio?ieuei? a?oie neeaaeaeeny c ?ioaeoieo oa i?aiaoaeueii no?aniaaieo
naioe?a ? naiie uo??a a?aeiia?aeiiai a?eo, ye? ia caciaee aino?iai
no?ano.

Aeine?aeaeaiiy aaeaioaoe?eieo iiaeeeainoae i?aai?cio i?iaiaeeee ca
oanoii aoiie [E.I. O?aooaiaa?a e ae?., 1987] o naioe?a ? naiie uo??a
a?eii 3-5, 11 oa 21 i?n. ?icaeoie o?ce/ii? aoiie i?aai?cio ioe?ithaaee
ca /anii (nae) oo?eiaiiy oaa?ei ia aa?oeeaeuei?e aea?aeei? ae?aiao?ii 2
ni oa aeiaaeeiith 50 ni.

Ooieoe?iiaeueiee noai ?ai?iaeoeoeaii? nenoaie o naiie uo??a ioe?ithaaee
ca oa?i?iii noaoaaiai aeic??aaiiy ?c ?a?no?aoe??th aeiae a?aee?eooy
i?oae oa no?oeoo?ith ? o?eaae?noth ano?aeueieo oeeee?a oeyoii uiaeaiiiai
i?e?ineii?/iiai ianoaaeaiiy i?oa’yieo iace?a i?ioyaii aeaio i?nyoe?a c
aeiae a?aee?eooy i?oae, a oaeiae i?ioyaii ia?oeo aeaio oeaei?a eiaeiiai
ae?oaiai i?nyoey o a?aeaeaeai? ia??iaee aeeooy (3, 4, 6, 8, 10, 12, 14,
16, 18, 20 ? 22- i?n).

Ii?oieia?/i? aeine?aeaeaiiy aaeaiia?iio?ca, ei?e iaaeie?eiaeo caeic, a
oaeiae eaoaoieai?ia?a?/ieo oa?i?iaeae na?aaeeiiiai ocaeooy i?iaiaeeee ca
aeiiiiiaith aeaeo?iiii? oa na?oiai? i?e?ineii??. Aeey oa?aeoa?enoeee
naen-aeeii?oieo yaea? iiceo (noi?ao?aciaoe/ieo yaea? oa a?eoaoiiai yae?a
a?iioaeaiona) aeei?enoiaoaaee ii?oiiao?e/iee aiae?c ia’?io yaea?
iae?ioeeo?a.

Noaoenoe/io ia?iaeo ?acoeueoao?a aeine?aeaeaiue i?iaiaeeee ?c
aeei?enoaiiyi t-e?eoa??th Nothaeaioa, iaia?aiao?e/iiai e?eoa??th U
A?eeieniia — Iaiia — O?oi?, a oaeiae iaoiaeo aeueoa?iaoeaiiai
aa??thaaiiy. ?ic?aooiie na?aaei?o iieaciee?a cae?enithaaee ca i?ia?aiith
aeey AII ia i?e?ieaeueeoeyoi?? “Yeaeo?iieea-IE-61“.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

?ieue ooieoe?iiaeueiiai iaoaaie?cio noaoaaeo ai?iii?a o ?icaeoeo
aiae?iaaiicaeaaeii? iaoieia?? ?ai?iaeoeoeaii? nenoaie

Ii?ooaiiy iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe?? aeine?aeaeoaaee ia
eeane/i?e iiaeae? iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a, yeo
a?aeoai?thaaee ca aeiiiiiaith ?i’?eoe?e aeciaaiiiai oanoinoa?iio
i?ii?iiaoo o e?eoe/iee ia??iae NAeI. A?aeiii, ui aieiaiei i?iyaii oeeo
ii?ooaiue ? ?icaeoie aiiaoeyoi?iiai neiae?iio, yeee oa?aeoa?eco?oueny
a?aenooi?noth oeeee?/ii? nae?aoe?? aiiaaeio?iiieo ai?iii?a. Iaeiae
iaoai?cie, ye? ciaoiaeyoueny o i?aea?oio? ia?aaoaeiae a?iioaeai?/ieo
oeaio??a ca /ieia?/ei oeiii i?ae /an NAeI, caeeoathoueny iac’yniaaieie.
I?e ?ica’ycaii? oe??? i?iaeaie iniiaia oaaaa aoea i?eae?eaia aiae?co
ooieoe?iiaeueii? aca?iiae?? i?ae noaoaaeie noa?i?aeaie oa eaoaoieai?iaie
o a?iioaeaion? iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a.

Aieiaiith ia?aaeoiiaith aeey oeueiai iai?yieo aeine?aeaeaiue aoei
aeyaeaiiy i?e/eiiiai ca’yceo i?ae i?aeaeuaiiyi ??aiy IA o a?iioaeaion? o
e?eoe/iee ia??iae NAeI oa ?icaeoeii aiiaoeyoi?ii? iaie?aeiino? o
iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a [A. Reznikov, N. Nosenko,
1983]. Oyaeaiiy i?i ?ieue EA o aiae?iaaiicaeaaei?e NAeI ae?noaei na?e
iiaeaeueoee ?icaeoie i?e aea/aii? noaoaaeo a?aei?iiinoae EA a?iioaeaiona
o ia??iae ?aiiueiai iinoiaoaeueiiai iioiaaiaco. Io?eiai? aeai?
na?ae/aoue i?i aeuee ??aaiue IA o a?iioaeaion? naioe?a, i?ae o naiie, ia
10-oo aeiao i?ney ia?iaeaeaiiy (eiio?ieuei? naioe?: 3,39 0,26 iiieue/a
oeaieie; eiio?ieuei? naiee: 2,56 0,16 iiieue/a oeaieie, P<0,05) (?en. 1). ?en. 1. Ai?no ii?aae?aiae?io a a?iioaeaion? ?ioaeoieo naioe?a oa naiie uo??a o ia??iae ?aiiueiai iinoiaoaeueiiai aeeooy. I?ei?oee. A?aei?iiino? noaoenoe/ii a??ia?aei? *P<0,05 (U-oano) ii??a- iyii c ?ioaeoieie naieaie (na?oe? noiai/eee). Ii in? i?aeeiao - eiioeaio- ?aoe?y ii?aae?aiae?io, iiieue/a oeaieie; ii in? aanoeen - aeiae aeeooy. Iiae?aia ca?eueoaiiy ai?noo IA o a?iioaeaion? 10-aeaiieo naiie aoei aeyaeaii i?ae aieeaii aeciaaiiiai OI, yeee aaiaeeee o aeic? 50 iea ia 5-o aeiao aeeooy (iaiiaoaeueii aiae?iaai?ciaai? naiee: 4,54 0,38 iiieue/a oeaieie; eiio?ieuei? naiee: 3,34 0,33 iiieue/a oeaieie, P<0,05) (?en. 2). ?en. 2. Ai?no ii?aae?aiae?io a a?iioaeaion? iaiiaoaeueii aiae?iaai?- ciaaieo naiie uo??a (OI) o ia??iae ?aiiueiai iinoiaoaeueiiai aeeooy. I?ei?oee. A?aei?iiino? noaoenoe/ii a??ia?aei? *P<0,05 (U-oano) ii??aiyii c eiio?ieueieie naieaie ( na?oe? noiai/eee). Ii in? i?aeeiao - eiioeaio?aoe?y ii?aae?aiae?io, iiieue/a oeaieie; ii in? aanoeen-aeiae aeeooy. ?acoeueoaoe aeine?aeaeaiue aeathoue i?aenoaao i?eionoeoe, ui oi?ioaaiiy noaoaaiai aeeii?o?cio a?iioaeai?/iiai ??aiy IA o e?eoe/iee ia??iae NAeI ia? nei??oa ai?iiiaeueio, i?ae aaiaoe/io iaoiiaeai?noue. Oea oaeiae i?aeoaa?aeaeo?oueny aeaieie, ui na?ae/aoue i?i a?eueoee ??aaiue IA o a?iioaeaion? ieiae?a ethaeeie /ieia?/i? noao? ia 14-16-e oeaeaeaiue aaa?oiino? (e?eoe/iee ia??iae NAeI o ethaeeie) o ia??iae i?aeeiio ??aiy O o e?ia? ii??aiyii ?c ieiaeaie ae?ii/i? noao? [D. Gilmore, C. Wilson, 1983]. Io?eiai? aeai? ?acii ?c ?acoeueoaoaie iiia?aaei?o aeine?aeaeaiue ?c aeei?enoaiiyi ?ia?a?oi?a neioaco EA - -iaoee-i-oe?iceio [A. Reznikov et al., 1979; I.Ae. Iinaiei, 1981] aeiaaee, ui ?iaeoeiaaiee aeciaaiiei OI i?aeeii ??aiy IA o a?iioaeaion? iiaiia?iaeaeaieo naiie ia? i?yia a?aeiioaiiy aei ai?iiiaeueii? ianeoe?i?caoe?? oa/aai aeaoai?i?caoe?? iiceo. Aeoiaey/e c oeueiai, aoei c?iaeaii aeniiaie, ui naia IA ? iiiiai?iii, yeee a?aeiia?aea? ca NAeI ca /ieia?/ei oeiii. Iiaeaeueo? coneeey aoee ni?yiiaai? ia c’ynoaaiiy i?e/eie oeueiai oaiiiaio. ?acoeueoaoe aenia?eiaio?a na?ae/aoue i?i iaaio ?ieue ooieoe?iiaeueiiai iaoaaie?cio aiae?iaai?a, a naia, a?iiaoecaoe?? O oa a?ae?ieneethaaiiy eiai ano?iaaiieo iaoaaie?o?a, o oeeo i?ioeanao. Aeey ioe?iee ?ie? ano?iaaiieo iaoaaie?o?a o aeaoai?i?caoe?? iiceo naiie uo??a i?ae aieeaii O aoee canoiniaai? ?ia?a?oi?e a?iiaoace N19 -noa?i?ae?a. Ca aeiiiiiaith eiia?iiaaiiiai aaaaeaiiy iiaiia?iaeaeaiei naieai uo??a OI ?acii ?c ?ia?a?oi?aie a?iiaoace aeiaaaeaii i?e/eiiee ca’ycie oeeo i?ioean?a ?c aeaoai?i?caoe??th iiceo naiie. Caeaaeii a?ae ni?aa?aeiioaiiy aeic oa o?eaaeino? ae?? i?aia?ao?a aoaeoe iaiiaoaeueii? aiae?iaai?caoe?? iineaaethaaeenue aai iineethaaeenue, aai caeeoaeenue aac ci?i. Cia/ia aaeueioaaiiy aeaoai?i?coth/i? ae?? OI (50 iea ia i’yoo aeiao aeeooy) a?aecia/aeinue i?ney iaeii?aciaiai aaaaeaiiy 1 ia AOAe a aeic? 1 ia aai 0,5 ia AO. E?euee?noue uo??a c ia?nenoaioiei ano?onii cia/ii ciaiooaaeanue ? noaiiaeea 15,7 % o ?ac? aaaaeaiiy OI AOAe ? 17,6 % o ?ac? aaaaeaiiy OI AO i?ioe 93,1 % o a?oi? iaiiaoaeueii aiae?iaai?ciaaieo oaa?ei, ye? io?eioaaee eeoa OI. Io?eiai? ?acoeueoaoe a?aeiinii caiia?aaiiy aeaoai?i?caoe?? iiceo iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a o ?ac? aeei?enoaiiy ?ia?a?oi??a a?iiaoace oe?eeii ocaiaeaeothoueny c aeaieie aeayeeo aaoi??a [P. Ruppert, L. Clemens, 1981; J. Booth, 1978; T. Iguchi et al., 1988]. I?ioa a ?ioiio aeiaaeeo, a naia i?ney iaeii?aciaiai aaaaeaiiy AOAe a aeic? 1 ia ?acii ?c OI (250 iea) ia ii/aoeo e?eoe/iiai ia??iaeo NAeI, a naia ia o?aoth aeiao aeeooy, e?euee?noue iaie?aeieo uo??a ia o?eueee ia ciaiooaaeanue, a iaa?oue i?aeaeuoaaeanue a?eueoa, ye o 2 ?ace ii??aiyii c oaa?eiaie, ye? io?eioaaee eeoa iaeei OI. Oea aeaco? ia oa, ui a inoaiiueiio aeiaaeeo i?eai?/aiiy a?iiaoecaoe?? aoei iaaeinoaoiuei o?eaaeei ? ?ia?a?oi? aeyaea aiae?iaaiio aeoeai?noue, yea iaea?eueo eiia??ii iia’ycaia c eiai iaeaaei?noth aei N19-noa?i?ae?a. Iiaeeeai, ui naia oe??th ianoaaeiith iiaeia iiynieoe noia?a/iee oa?aeoa? aeaieo e?oa?aoo?e a?aeiinii oeueiai ieoaiiy [S. Hayashi, 1979]. Anoaiiaeaii, ui i?ioaeoi?ia ae?y ?ia?a?oi??a a?iiaoace a?aeiinii ?icaeoeo aiiaoeyoi?ii? iaie?aeiino? o iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a iaoiiaeaia ?o caeaoi?noth aeieoaaoe ?iaeoeiaaia OI c?inoaiiy eiioeaio?aoe?? IA oa AeA o a?iioaeaion? a e?eoe/iee ia??iae NAeI. Aaaaeaiiy ?ia?a?oi??a a?iiaoace ia i’yoo oa nueiio aeiae aeeooy i?ney ia?iaeaeaiiy caiia?aaei i?aeeiio ??aiy EA o a?iioaeaion? iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a 10-aeaiiiai a?eo. Oea ni?eyei caa?aaeaiith noaoaai? oeeee?/iino? o aei?ineeo oaa?ei. Io?eiai? aeai? aeathoue i?aenoaao ae?eoe aeniiaeo: 1) a?iiaoe/ia eiiaa?n?y aiae?iaai?a o ano?iaaie ? iaiao?aeiith oiiaith aeey ?aae?caoe?? ianeoe?i?coth/iai aieeao aiae?iaai?a ia aeeoa?aioe?aoe?th a?iioaeai?/ieo oeaio??a ?aaoeyoe?? oeeee?/ii? nae?aoe?? aiiaaeio?ii?i?a; 2) iaoai?ci ?aae?caoe?? oeueiai aieeao iia’ycaiee ?c noeioeyoe??th iaeiie/aiiy EA o a?iioaeaion?. Ianooiiee aoai ?iaioe iieyaaa o c’ynoaaii? ieoaiiy, /e ? oeae ca’ycie i?ae ano?iaaiieie iaoaaie?oaie oa EA i?yiee, aai ae iiina?aaeeiaaiee e?ioeaaeie i?iaeoeoaie iaoaaie?cio O, a naia eaoaoieano?iaaiaie (EA). A?aeiii, ui EA ooai?ththoueny aiane?aeie a?ae?ieneethaaiiy ano?iaaiieo iaoaaie?o?a o OeIN ? caaaeyee nai?i oi?eaeueiei aeanoeainoyi ? iaeieie ?c iaeneeuei?oeo ?ia?a?oi??a iaoaaie?cio EA [P. Ball, R. Knuppen, 1980]. E??i oiai, EA caeo/ai? aei iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe??, a naia aei ?aaoeyoe?? nae?aoe?? aiiaaeio?ii?i?a oa noaoaai? iiaaae?iee [N. MacLusky et al., 1981]. O aeine?aeao ?c aeei?enoaiiyi ??cieo ?ciia??a EA, ye? aaiaeeee iiaiia?iaeaeaiei naieai uo??a eiaeai ie?aii i?ae oe??o a aeic? 10 iea i?ioyaii ia?oeo i’yoe ae?a i?ney ia?iaeaeaiiy, aoei aeyaeaii aeinoia??ia i?aeaeuaiiy eiioeaio?aoe?? IA a a?iioaeaion?, a naia: /a?ac 30 oa i?ney inoaiiuei? ?i’?eoe?? 2-II-A1, /a?ac 1 aiae i?ney aaaaeaiiy 4-II-A2-17, /a?ac 4 aiae i?ney aaaaeaiiy 2-II-A2 oa /a?ac 24 aiae i?ney aaaaeaiiy 4-II-A2-17 (?en. 3). ?en. 3. Aieea eaoaoieano?iaai?a ia eiioeaio?aoe?th ii?aae?aiae?io a a?iioaeaion? iiaiia?iaeaeaieo naiie uo??a. I?ei?oee. Iaaaaeai? aeai? a?aeiia?aeathoue iaeneiaeueiiio i?aeaeuaiith eiioeaio?aoe?? ii?aae?aiae?io. ??cieoey a??ia?aeia *P<0,05 (U-oano) aeey aoae- oo eaoaoieano?iaai?a (oaii? noiai/eee) ii??aiyii c a?aeiia?aeiei eiio?i- eai (na?oe? noiai/eee). Ca?aeii cai?iiiiiaaii? a?iioace i?i i?yiee a?io?i?/iee ca’ycie i?ae iaoaaie?ciii O oa EA, aeyaeaia i?aeaeuaiiy eiioeaio?aoe?? EA o a?iioaeaion? iiaiia?iaeaeaieo naiie uo??a i?ney nenoaiiiai aaaaeaiiy EA aoei nei??oa i/?eoaaiei, i?ae ianiiae?aaiei. Oea aeaaaei iiaeeea?noue iiynieoe aeyaeaiee oaiiiai ?iaeoeiaaiiai O i?aeeiio ??aiy EA o a?iioaeaion? a e?eoe/iee ia??iae NAeI. Aea anoaiiaeaiee oaeo ua ia aeaaaa a?aeiia?ae? ia caieoaiiy, /e caeaoi? EA cae?enithaaoe aeaoai?i?coth/ee aieea ia NAeI oae naii, ye O, ? ye? naia EA ca oea a?aeiia?aeaeuei?. ?ai?oa aoei c?iaeaii i?eiouaiiy [A.A. ?acieeia, 1978-1982; I.Ae. Iinaiei, 1981], ui EA iiaeooue a?ae?a?aaaoe ?ieue i?e?iaeieo ianaiaeaea??a o aeaoai?i?coth/iio aieea? O ia a?iioaeaion, yeee ?icaeaa?oueny. Aea ia ii/aoeo ?iaioe ?nioaaei eeoa ?aeeia iia?aeiieaiiy i?i oa, ui iaiiaoaeueia aaaaeaiiy 2-II-A2-17 naieai uo??a o aeic? 5 iea ni?e/eith? aiiaoeyoi?io iaie?aei?noue ?, oaeei /eiii, a?aeoai?th? aoaeoe O aai ano?aae?ieo [N. Parvizi, F. Naftolin, 1977]. I?ae oei, o i?iaaaeaieo aeine?aeaeaiiyo ia aeyaeaii aoaeue-yeiai aieeao 2-II-A2-17 aai 2-II-A1, ca aeiyoeii cao?eiee ia 5-7 ae?a a?aee?eooy i?oae, i?ney nenoaiiiai iaeii?aciaiai aai aaaaoi?aciaiai aaaaeaiiy naieai uo??a o aeicao 5-25 iea i?ioyaii ia?oeo ae?a i?ney ia?iaeaeaiiy aai i?ney ?io?aoea?aa?aeueieo ?i’?eoe?e EA o aeic? 5 iea ia o?aoth aai i’yoo aeiao aeeooy. Aiaeii/an aoee io?eiai? aeai? i?i aenieo aeaoai?i?coth/o aeoeaiinoue ?ioiai ?ciia?a 4-II-A2-17, yeee iaeaea iiai?noth a?aeoai?thaaa aeaoai?i?coth/ee aoaeo OI a?aeiinii ?icaeoeo aiiaoeyoi?ii? iaie?aeiino? (80% aeiaaee?a). Ia a?aei?io a?ae 4-II-A2-17, eiai 17-?ciia?, yeee ia? iecueeo nii??aeiai?noue aei ?aoeaioi??a ano?iaai?a ? a?aeiia?aeii ieae/o ano?iaaiio aeoeai?noue, ia ii?oooaaa noaoaao oeeee?/i?noue o naiie. Oeae oaeo iiaea ?icaeyaeaoeny ye aeiaeaoeiaee a?aoiaio ia ei?enoue oiai, ui naia 4-II-A2-17 ? iniiaiei ai?iiiaeueiei ?iaeoeoi?ii ianeoe?i?caoe?? iiceo, yeee aeeiio? ?ieue ianaiaeaea?a o aeaoai?i?coth/iio aieea? O ia NAeI naiie uo??a. Ni?anoaaeaiiy io?eiaieo ?acoeueoao?a aea? ciiao c?iaeoe aeniiaie i?i ooieoe?iiaeueiee ca’ycie i?ae ?iaeoeiaaiei 4-II-A2-17 i?aeaeuaiiyi ??aiy IA o a?iioaeaion? iiaiia?iaeaeaieo naiie uo??a oa aeaoai?i?coth/ei aieeaii oeueiai EA ia iicie, ui ?icaeaa?oueny. O iiai?e a?aeiia?aeiino? c aeeeaaeaiith a?iioacith ciaoiaeyoueny niinoa?aaeaiiy i?i i?aeaeuaiiy ai?noo IA o a?iioaeaion? iiaiia?iaeaeaieo naiie /a?ac 24 aiae i?ney inoaiiuei? ?i’?eoe?? 4-II-A2-17, yeee aaiaeeee a aeic? 10 iea ia aeiao i?ioyaii ia?oeo i’yoe ae?a aeeooy (aeea. ?en. 2.). Oie oaeo, ui i?e oeueiio ??aaiue AeA caeeoaany aac ci?i (eiio?ieue: 3,04 0,20 iiieue/a oeaieie; 4-II-A2-17: 2,79 0,16 iiieue/a oeaieie), aeaco? ia ae??oaeueio ?ieue IA o ?aae?caoe?? aeaoai?i?coth/iai aieeao oeueiai ano?iaaiiiai iaoaaie?oo ia iicie, ui ?icaeaa?oueny. Oaeei /eiii, i?aenoiiaoth/e ?acoeueoaoe aeine?aeaeaiue aieeao EA ia NAeI, iiaeia ae?eoe aeniiaeo i?i oa, ui aieiaiei /eiieeii, yeee aaciina?aaeiuei a?aeiia?aea? ca ?iaeoeiaaia O i?aeaeuaiiy a?iioaeai?/ii? eiioeaio?aoe?? IA o e?eoe/iiio ia??iae? NAeI, ? 4-II-A2-17. I?ioean iaeiie/aiiy IA o a?iioaeaion? iiaiia?iaeaeaieo naiie uo??a iiaea a?aeaoaaoeny aiane?aeie eiieo?aioii? aca?iiae?? 4-II-A2-17 ?c EIIO, yeee cae?enith? iaoaaie?/io ?iaeoeaaoe?th EA oeyoii aiceiaoe/iiai iaoeethaaiiy. Oaeei /eiii, i?yiee a?io?i?/iee ca’ycie i?ae noaoaaeie noa?i?aeaie oa EA i?ae /an NAeI eiia??ii iiina?aaeeiaaiee 4-II-A2-17 ca o/anoth EIIO. A?aoiaioii ia ei?enoue i?ia?aeii? ?ie? EIIO o a?io?i?/iiio ca’yceo i?ae iaoaaie?ciii O oa EA o e?eoe/iee ia??iae aiae?iaaiicaeaaeii? NAeI ? cieaeaiiy aeoeaiino? EIIO o a?iioaeaion? naioe?a ii??aiyii c naieaie, ii/eiath/e c 8-i? aeiae iinoiaoaeueiiai ?icaeoeo [W. Ladosky, H. Schneider, 1981]. I?aeeii ??aiy IA o a?iioaeaion? naioe?a uo??a ia 10-oo aeiao aeeooy, a oaeiae i?aeaeuaiiy ai?noo IA o naiie uo??a i?ae aieeaii aeciaaiiiai OI ei?aeth? ?c cieaeaiiyi aeoeaiino? EIIO ? iiaea ?icaeyaeaoeny ye iane?aeie aieeao O o e?eoe/iee ia??iae NAeI. Iiaeaeueo? aeine?aeaeaiiy aoee ni?yiiaai? ia ae??oaiiy ieoaiiy: ui naia ? ae??oaeueiei o ae?? EA ia iicie, ui ?icaeaa?oueny, eiai ai?iiiaeueiee aoaeo /e caeo/aiiy EA-a?a?/iiai eaioethaa. ?ieue ooieoe?iiaeueii? aca?iiae?? noa?i?aeieo iaoaaie?o?a ? eaoaoieai?i?a ye ?iaeoeoi??a aeic??aaiiy iae?iaiaeie?eiii? nenoaie ?aaoeyoe?? ?ai?iaeoeoe?? ?acoeueoaoe aenia?eiaio?a ?c aeei?enoaiiyi ?ia?a?oi?a EIIO o?iiieiio oa iiia?aaeieea neioaco EA L-AeIOA, ye? aaiaeeee iiaiia?iaeaeaiei naieai uo??a iiiaeeioe? aai ?acii ?c OI aai EA, aeiaaee, ui EA iaa?yae /e ? naiino?eiei /eiieeii NAeI. Aaaaeaiiy o?iiieiio oa L-AeIOA o ?aii?e iinoiaoaeueiee ia??iae ia ni?e/eieei ?icaeoie aiiaoeyoi?ii? iaie?aeiino?. Oaeei /eiii, ooo/ia i?aeaeuaiiy ??aiy EA o iiceo iiaiia?iaeaeaieo naiie uo??a i?ae /an NAeI naii ii nia? ua iaaeinoaoiuei aeey ia?aaoaeiae ?icaeoeo iiceo ca /ieia?/ei oeiii, a ioaea EA ia iiaeooue ?icaeyaeaoeny ye aeeeth/i? ?iaeoeoi?e NAeI. C oeueiai aeieeaa?, ui aeey aeaoai?i?caoe?? oa/aai ianeoe?i?caoe?? iiceo iaiao?aeia i?enooi?noue eieaeueii iiaiooai?aieo ano?iaai?a aai EA. Oea i?aeoaa?aeaeo?oueny aeaieie i?i i?enei?aiiy oa?i?io noaoaaiai aeic??aaiiy oa iineeaiiy noa?ee?coth/iai aoaeoo OI ca oiia cieaeaiiy aeoeaiino? EIIO. ?icaeoie aiiaoeyoi?ii? iaie?aeiino? o iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a, ye? io?eioaaee ?i’?eoe?? o?iiieiio a aeic? 100 iea c 4-i? ii 10-oo aeiae aeeooy, niinoa??aaany o 100 % aeiaaee?a i?ioe 66,6 % o ?ac? aaaaeaiiy OI aac o?iiieiio (?<0,05). A?aoiaoth/e aeai? e?oa?aoo?e i?i i?eai?/aiiy aeoeaiino? EIIO o iiaiia?iaeaeaieo naiie uo??a i?ae aieeaii aeciaaiiiai OI [W. Ladosky et al., 1984], iineeaiiy aieeao iaiiaoaeueii? aiae?iaai?caoe?? iiaeia ?icaeyaeaoe ye ?acoeueoao aeiaeaoeiaiai aieeao o?iiieiio ia EIIO, aiane?aeie /iai i?aeaeuo?oueny ??aaiue a?iioaeai?/ieo iiiiai?i?a i?ae /an NAeI. Iaaoaeoeai?noue aeei?enoaiiy o?iiieiio ?acii ?c 2-II-A2-17 noiniaii ?iaeoeoe?? aiiaoeyoi?ii? iaie?aeiino? i?aeoaa?aeaeo? i?eiouaiiy a?aeiinii oiai, ui 2-a?ae?ieneeueiaai? ano?iaaii? iaoaaie?oe ia a?ae?a?athoue ?ieue ?iaeoeoi??a o NAeI. Oaeei /eiii, ?acoeueoaoe aeine?aeaeaiue aeathoue ciiao ae?eoe aeniiaeo, ui NAeI ? ?acoeueoao ii?aeiaiiai aieeao ano?iaaiieo iaoaaie?o?a, cie?aia 4-II-A2-17, oa EA ia iicie, ui ?icaeaa?oueny. Aeiaeaoeia? i?aeoaa?aeaeaiiy iieiaeaiiy i?i caeo/aiiy EA a aiae?iaaiicaeaaeio aeaoai?i?caoe?th iiceo aoee io?eiai? o aeine?aeao ?c aeei?enoaiiyi 6-II-AeA. E?eoa??yie aeey ioe?iee noaio EA-a?a?/ii? nenoaie iiceo iiaiia?iaeaeaieo iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a ca oiia iaiiaoaeueiiai aieeao 6-II-AeA aoee ci?ie o no?oeoo?i?e i?aai?caoe?? EA-a?a?/ieo oa?i?iaeae na?aaeeiiiai ocaeooy oa ai?noo EA o a?iioaeaion? i?ae /an NAeI. ?acoeueoaoe aeine?aeaeaiue na?ae/aoue, ui aaaaeaiiy 6-II-AeA a aeic? 100 ia/ea iane o?ea i?ioyaii ia?oeo aeaio ae?a i?ney ia?iaeaeaiiy ia ni?e/eieei cia/iiai iioeiaeaeaiiy EA-a?a?/ieo no?oeoo? na?aaeeiiiai ocaeooy ye o ?ioaeoieo, oae ? o iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a 10-aeaiiiai a?eo (50 iea OI iaeii?aciai ia i’yoo aeiao aeeooy), ? aeeeeeaei eeoa ieanoe/io ia?aaoaeiao ? aeaaaia?aoe?th o iiiaeeiieeo aeniiieo oa?i?iaeyo na?aaeeiiiai ocaeooy. Oe? niinoa?aaeaiiy oe?eeii ocaiaeaeothoueny ?c aeaieie i?i a?aenooi?noue aeinoia??ieo ci?i ai?noo EA o a?iioaeaion? i?ney iaiiaoaeueiiai aieeao 6-II-AeA. Naia oeae oaeo iiynith? iacaeaoi?noue 6-II-AeA caiia?aaoe ?icaeoeo aiiaoeyoi?ii? iaie?aeiino?, ?iaeoeiaaii? OI. I?aenoiiaoth/e ?acoeueoaoe aeine?aeaeaiue, iiaeia ae?eoe aeniiaeo i?i oa, ui ooieoe?iiaeueia aca?iiae?y ano?iaaiieo iaoaaie?o?a oa EA o i?ioeanao aiae?iaaiicaeaaeii? NAeI cae?enith?oueny ca iaoai?ciii ei?iaeoeoe??, o yeiio ai?iiie oa iaae?aoi?e ni?eueii aenooiathoue o ?ie? ?iaeoeoi??a noaoaai? aeeoa?aioe?aoe?? a?iioaeaiona oa i?aai?caoi??a ?icaeoeo iae?iaiaeie?eiii? nenoaie ?ai?iaeoeoe??. A iiia?aaei? ?iee iaie [A.A. ?acieeia, 1978-1982; I.Ae. Iinaiei, 1981], a oaeiae ?ioeie aeine?aeieeaie [A.A. Aocieeia, 1967; A.A. Aocieeia e ae?., 1997; O.I. O?aoueye, E.A. A?oeiiaa, 1992] aoei aeneiaeaii i?eiouaiiy i?i iiaeeea?noue ?nioaaiiy ia ?aii?o aoaiao iioiaaiaco “aeiia?aiaeo” oi?i iaae?aoi?iiai i?ioeano, a yeiio iae?iiaae?aoi?e iiaeooue ooieoe?iioaaoe ye eieaeuei? oeaieii? ai?iiie. Ca?aeii ?c cai?iiiiiaaiith a?iioacith, IA aa?a o/anoue o oeueiio i?ioean? ia ye neiaioe/iee o?aini?oa?, a nei??oa ye aoii?aeueiee ?iaeoeoi? aeeoa?aioe?thaaiiy ia?aiaeo ee?oei, oiaoi, ye eieaeueiee oeeoiai?iii. Iiaeeeai, ui ?iaeoeoi?ia ae?y IA cae?enith?oueny oeyoii aeoiaeo iaae?aoi?a ?c ianeiaioe/ieo a?ae?inoe?a IA-a?a?/ieo iae?ii?a oa eiioaeoo c ano?iaaii/ooeeaeie AAIE-a?a?/ieie oa ?ioeie iae?iiaie a?iioaeaiona, ye? aa?ooue o/anoue o ?aaoeyoe?? nae?aoe?? aiiaaeio?ii?i?a. Ia ei?enoue ?aea? uiaei ianeiaioe/iiai aoaeoo a?iaaiieo iiiiai?i?a na?ae/aoue aeai? i?i caeaoi?noue EA i?iieeaoe o ia?aia? ee?oeie ? aaciina?aaeiuei aca?iiae?yoe c yaea?iei o?iiaoeiii yae?a [A.O. Aiaeei, 1985] ?, oaeei /eiii, iiaeeo?eoaaoe aaiiiio aeoeai?noue o iae?iiao aieiaiiai iiceo, yea caa??aa?oueny ai?iaeiaae onueiai aeeooy i?aai?cio. Anoaiiaeaiiy ?ie? ano?iaaiieo iaoaaie?o?a oa EA o ?aaoeyoe?? ?icaeoeo iae?iaiaeie?eiii? iaoieia?? ?ai?iaeoeoe?? noai?eei i?aea?oioy aeey iae?io?i?/ii? eiioeaioe?? aiae?iaaiicaeaaeii? NAeI, ca?aeii c yeith iniiaieie aoaiaie aeaoai?i?coth/iai oa/aai ianeoe?i?coth/iai aieeao O ia iaaeeoa?aioe?eiaai? a?iioaeai?/i? oeaio?e, ye? cae?eniththoue eiio?ieue nae?aoe?? aiiaaeio?ii?i?a, ?: 1) a?iiaoecaoe?y O; 2) ooai?aiiy EA, cie?aia 4-II-A2-17; 3) aca?iiae?y EA c ano?iaaiieie ?aoeaioi?aie oa oa?iaioaie neioaco oa iaoaaie?cio IA; 4) ii?aeiaiee aieea ano?iaaiieo iaoaaie?o?a oa IA ia aaiii ee?oeie. Ia?eiaoaeueia no?ani?ia oa ai?iiiaeueia iiaeeo?eaoe?y noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie iiceo uo??a o ia??iae ?aiiueiai iioiaaiaco Aeciaiiy cia/ii? ?ie? EA ?, cie?aia, IA a aiae?iaaiicaeaaei?e NAeI aeicaiey? e?aua c?icoi?oe iaoai?ci iaoiaaiiiai aieeao i?aiaoaeueiiai no?ano oa ai?iiiaeueiiai aeenaaeaino ia iae?iaiaeie?eiio nenoaio oaa?ei. Aeey c’ynoaaiiy iaoai?ci?a ?iaeoeiaaieo i?aiaoaeueiei no?anii iae?io?i?/ieo ci?i aaaeeeaa cia/aiiy ia? aiae?c oaeeo iieaciee?a, ye ai?no oa iaoaaie?/iee ia?a a?iaaiieo ai?i?a o aeene?aoieo no?oeoo?ao iiceo, ye? i?e/aoi? aei ?ai?iaeoeoe?? oa aaeaioaoe??, o ?aiiueiio iioiaaiac?. Iaea?aeai? ?acoeueoaoe na?ae/aoue i?i oa, ui ?iiia?e?caoe?eia no?anoaaiiy aaa?oieo uo??a (15-21 aeiae aaa?oiino?) ni?e/eith? iaai? ci?ie o no?oeoo?i?e oa ooieoe?iiaeuei?e i?aai?caoe?? iniiaieo eaiie iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoeaii? nenoaie o ?oi?o iauaaee?a iaio noaoae. Ianaiia?aae oea noino?oueny i?ioean?a oi?ioaaiiy noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion?, ye? ioioiaeiththoue ?c oeaio?aie ?aaoeyoe?? noaoaai? iiaaae?iee oa nae?aoe?? aiiaaeio?ii?i?a ? iaoeyoe?? [G. Dorner et al., 1968]. ?acoeueoaoe aeine?aeaeaiue aeiaaee ?nioaaiiy noaoaaiai aeeii?o?cio ai?noo IA o i?aiioe/i?e ae?eyioe? oa AeA o iaae?iaacaeueiiio a?iioaeaion? ?ioaeoieo uo??a ia 10-oo aeiao aeeooy. I?e oeueiio ??aaiue IA o i?aiioe/i?e ae?eyioe? aoa a?eueoee o naiie (naiee - 4,39 0,56 iiieue/a oeaieie; naioe? - 2,95 0,18 iiieue/a oeaieie, ?<0.05), a AeA o iaae?iaacaeueiiio a?iioaeaion? - o naioe?a (naiee - 2,43 0,14 iiieue/a oeaieie; naioe? - 4,72 0,75 iiieue/a oeaieie, P<0,05) (?en.4). ?en. 4. Aieea i?aiaoaeueiiai no?ano ia ai?no eaoaoieai?i?a o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? naioe?a ? naiie uo??a 10-aeaiiiai a?eo. I?ei?oee: ??cieoey a??ia?aeia *?<0,05 (U-oano) ii??aiyii: a - c eiio?ieueieie naieaie; b - c eiio?ieueieie naioeyie; n - c i?aiaoaeueii no?aniaaieie naieaie. Na?oe? noiai/eee - naiee; oaii? - naioe?. Aiaeia?/i? aeai? uiaei noaoaaeo ?ica?aeiinoae ai?noo IA o iaae?aeuei?e i?aiioe/i?e ae?eyioe? aoei iaea?aeaii Flugge, Fuchs (1985). O iiai?e a?aeiia?aeiino? ?c ci?iaie ??aiy IA o i?aiioe/i?e ae?eyioe? oaeaee?noue ia?ao ooieoe?iiaeueiiai ioeo iiiiai?io o ia?oo aiaeeio aeieaaee neioaco EA o naioe?a c?inoaea, a o naiie, iaaiaee, cieaeoaaeanue. Ca?eueoaiiy ai?noo AeA o iaae?iaacaeueiiio a?iioaeaion? naioe?a noi?iaiaeaeoaaeinue i?enei?aiiyi ia?ao iiiiai?io. No?anoaaiiy aaa?oieo naiie caeaoii ni?e/eiyoe ?aii? iinoiaoaeuei? ci?ie EA-a?a?/ii? nenoaie o ?oi?o iauaaee?a. Iaoa?einueeee no?an onoaaa noaoaa? a?aei?iiino? ai?noo oa ia?ao iiiiai?i?a o iiceo 10-aeaiieo uo??a, ye? niinoa??aaeeny o ?ioaeoieo oaa?ei (aeea. ?en. 4). Ai?no IA o i?aiioe/i?e ae?eyioe? i?aiaoaeueii no?aniaaieo naioe?a ca?eueooaaany aei ??aiy, i?eoaiaiiiai ii?iaeueiei naieai. I?e oeueiio ia?a ooieoe?iiaeueiiai ioeo iiiiai?io o i?aiioe/i?e ae?eyioe? i?aeaeine?aeieo naioe?a oiia?eueithaaany. I?aeaeuaiiy ai?noo ? a?aeiia?aeii cieaeaiiy ia?ao IA o i?aiioe/i?e ae?eyioe? i?aiaoaeueii no?aniaaieo naioe?a aei ??aiy, i?eoaiaiiiai ii?iaeueiei naieai, iiaea aooe coiiaeaii ciaioaiiyi ??aiy O o e?ia? ieiae?a ? iiaiia?iaeaeaieo naioe?a no?aniaaieo iaoa??a [I. Ward, J. Weisz, 1980, 1984; F. Stahl et al., 1978]. Oe?eeii eiia??ii, ui ?aii? iinoiaoaeuei? ci?ie ??aiy oa ia?ao IA o i?aiioe/i?e ae?eyioe? i?aiaoaeueii no?aniaaieo naioe?a, aea ?icoaoiaaiee oeaio? /ieia?/i? noaoaai? iiaaae?iee, iiaeooue aeaoa?i?ioaaoe iiaeaeueoo aeaianeoe?i?caoe?th oa/aai oai?i?caoe?th /ieia?/i? noaoaai? iiaaae?iee. Io?eiai? aeai? ocaiaeaeothoueny ?c ?acoeueoaoaie aeine?aeaeaiue I. Ward (1972), yeee niinoa??aaa iineaaeaiiy /ieia?/i? noaoaai? iiaaae?iee o i?aiaoaeueii no?aniaaieo naioe?a. Io?eiai? aeai? ? ua iaeiei aeieacii oiai, ui i?aiaoaeueiee no?an o cia/ii a?eueo?e i??? ii?ooo? iae?iaiaeie?eiio nenoaio ieiae?a /ieia?/i? noao?, i?ae ae?ii/i?. Iniaeeaee ?ioa?an uiaei aiae?co a?aeaeaeaieo iane?aee?a i?aiaoaeueiiai no?ano o naiie uo??a iathoue ?aii? iinoiaoaeuei? ci?ie ai?noo oa ia?ao IA oa AeA o iaae?iaacaeueiiio a?iioaeaion?, o yeiio eieae?ciaaiee oeaio? ae?ii/i? noaoaai? iiaaae?iee oa iaoeyoe??. Caa?aaeaiiy ii?iaeueiiai ai?noo oa ia?ao IA o iaae?iaacaeueiiio a?iioaeaion? i?aiaoaeueii no?aniaaieo naiie uo??a oe?eeii ocaiaeaeo?oueny c a?aenooi?noth o ieo nooo?aeo ii?ooaiue iaoeyoi?ieo iaoai?ci?a. C ?ioiai aieo, ca?eueoaiiy ai?noo AeA o iaae?iaacaeueiiio a?iioaeaion? i?aiaoaeueii no?aniaaieo naiie aei ??aiy, i?eoaiaiiiai ii?iaeueiei naioeyi, iiaea aooe a??ia?aeiith i?e/eiith aeayeeo ?iceaae?a ae?ii/i? noaoaai? iiaaae?iee oa ?ioeo ?ai?iaeoeoeaieo i?ioean?a, cie?aia cao?eiee noaoaaiai aeic??aaiiy oa ii?ooaiue oaciai? no?oeoo?e ano?aeueieo oeeee?a, ye? ie niinoa??aaee o aei?ineeo oaa?ei . Caneoaiao? ia oaaao oie oaeo, ui o aeine?aeao, ye? aoee aeeiiai? ia iiaeae? iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a, ai?no oa ia?a IA ? AeA o iaae?iaacaeueiiio a?iioaeaion? iaa?oue ia?aaeuoaaee oaeee o ii?iaeueieo naioe?a, ui, oe?eeii eiia??ii, iiaea a?ae?a?aaaoe /eiaeo ?ieue o ?icaeoeo aiiaoeyoi?ii? iaie?aeiino? oa aeaoai?i?caoe?? oa/aai ianeoe?i?caoe?? ae?ii/i? noaoaai? iiaaae?iee. Oaeei /eiii, ?acoeueoaoe aeine?aeaeaiue aeathoue i?aenoaao c?iaeoe aeaa aeniiaee. Ii-ia?oa, EA aieiaiiai iiceo ? o??th ni?eueiith iae?io?i?/iith eaieith, eio?a coiiaeth? ?iceaaee NAeI o oaa?ei aiane?aeie ye i?aiaoaeueiiai no?ano, oae ? aeenaaeaino noaoaaeo ai?iii?a o iiaiia?iaeaeaieo uo??a. Ii-ae?oaa, ?aii? iinoiaoaeuei? aoaeoe i?aiaoaeueiiai no?ano oa iaiiaoaeueii? aiae?iaai?caoe?? a?ae??ciythoueny ca nai?th no?oeoo?iith eieae?caoe??th ? iathoue naenniaoeeo?/iee oa?aeoa?, a naia: aieea i?aiaoaeueiiai no?ano ?aae?co?oueny ia ??ai? i?aiioe/ii? ae?eyiee ia?aaaaeii o naioe?a, aoaeoe iaiiaoaeueii? aiae?iaai?caoe?? ia ??ai? iaae?iaacaeueiiai a?iioaeaiona o naiie. Aieea i?aiaoaeueiiai no?ano oa ai?iiiaeueiiai aeenaaeaino ia iae?i-aiaeie?eiio nenoaio /anoeiai ?aae?co?oueny ?c caeo/aiiyi NO-a?a?/ii? nenoaie iiceo. A?aeiii, ui NO-a?a?/ia nenoaia iiceo, ui ?icaeaa?oueny, /ooeeaa aei ci?i ??aiy AEOA oa ei?oeeinoa?iio o ieaci? e?ia? [D. Peters, 1990]. Oea aea? ciiao i?eionoeoe, ui ci?ie noaoaai? iiaaae?iee o iauaaee?a no?aniaaieo iaoa??a oaeiae iiaeooue aooe iia’ycai? ?c ci?iaie o oe?e iiiiai?ia?a?/i?e nenoai? i?ae /an NAeI. Io?eiai? aeai? na?ae/aoue i?i iayai? noaoaa? ?ica?aeiino? iaoaaie?/iiai ia?aoai?aiiy NO oa ai?noo eiai iniiaiiai iaoaaie?oo 5-A?IE o i?aiioe/i?e ae?eyioe? (?en. 5). ?en. 5. Aieea i?aiaoaeueiiai no?ano ia ai?no oa ia?a na?ioii?io o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? naioe?a ? naiie uo??a 10-aeaiiiai a?eo. I?ei?oee. ??cieoey a??ia?aeia *P<0,05 (U-oano) ii??aiyii c naieaie. E - eiio?ieuei? oaa?eie, IN - i?aiaoaeueii no?aniaai?. Na?oe? noiai/eee - naiee; oaii? - naioe?. Oe?eeii eiia??ii, ui i?aeaeuaiee ia?a NO o i?aiioe/i?e ae?eyioe? ii?iaeueieo naioe?a i?ae /an NAeI iiaea aeayeith i??ith aecia/aoe ?icaeoie /ieia?/iai oeio noaoaai? iiaaae?iee o aei?ineeo oaa?ei. Aeiaeaoeia? i?aenoaae aeey oeueiai aeniiaeo aeathoue ?acoeueoaoe aeine?aeaeaiiy aieeao no?ano oa aeenaaeaino noa?i?aeieo ai?iii?a o ia?eiaoaeueiee ia??iae ia oi?ioaaiiy noaoaaiai aeeii?o?cio NO-a?a?/ii? nenoaie o ia??iae ?aiiueiai iioiaaiaco. ?acoeueoaoe aeine?aeaeaiue na?ae/aoue i?i iaeiini?yiiaai?noue ooeiaeaeoth/eo aieea?a i?aiaoaeueiiai no?ano oa iaiiaoaeueii? aiae?iaai?caoe?? ia ?icaeoie noaoaaiai aeeii?o?cio iaoaaie?/iiai ia?aoai?aiiy NO o i?aiioe/i?e ae?eyioe?. Oe?eaai a?aei?oeoe, ui ?iaeaen iaoaaie?cio NO, yeee oa?aeoa?eco? ia?a ?iaeieai?io, i?aeaeuoaaany ye o i?aiaoaeueii no?aniaaieo, oae ? iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a, aei ??aiy, i?eoaiaiiiai ii?iaeueiei naioeyi. Aiaeii/an i?aiaoaeueiee no?an aeeeeeaa iiyao noaoaaeo a?aei?iiinoae ai?noo NO oa 5-A?IE o iaae?iaacaeueiiio a?iioaeaion? ca ?aooiie i?aeaeuaiiy ?oiueiai ??aiy o i?aiaoaeueii no?aniaaieo naioe?a (aeea. ?en. 5). A?aoiaoth/e ?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue, iiaeia i?eionoeoe, ui ci?ie NO-a?a?/ii? aeoeaiino? o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? iiaeooue aooe aaaeeeaei aoaiii o ?icaeoeo iaaieo ?iceaae?a o ae?ii/?e oa /ieia?/?e noaoaa?e iiaaae?ioe?, a oaeiae ?aaoeyoe?? nae?aoe?? aiiaaeio?iiieo ai?iii?a. Ca?aeii ?c eiioeaioe??th e?eoe/ieo ia??iae?a, o oa?i?ie iaea?eueo ?ioaineaiiai ?icaeoeo EA nenoaia iiceo ia? i?aeaeuaio /ooeea?noue aei ciai?oi?o oa aioo??oi?o /eiiee?a, ye? iiaeooue i?iyoe ?? iioiaaiac oa ianooiio ooieoe?th. Na?aae /eiiee?a, ui aieeaathoue ia EA-a?a?/io nenoaio, aaaeeeaa ?ieue iaeaaeeoue aetheiei?oeei?aeai. Aaaaeaiiy aetheiei?oeei?ae?a aaa?oiei naieai [E. Naumenko, N. Dygalo, 1984; A.A. Iaoiaiei e ae?., 1990] aai iiaiia?iaeaeaiei uo?ai [E.I. Ianeiaa, A.A. Iaoiaiei, 1990] ni?e/eiythoue aeiaaio?eaaeee aieea ia EA-a?a?/io nenoaio iiceo oaa?ei [L. Takahashi et al., 1992]. Iaeiae ieoaiiy a?aeiinii ?ie? aetheiei?oeei?ae?a iaoa?einueeiai i?aai?cio a ?iaeoeiaaieo i?aiaoaeueiei no?anii ci?iao noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie iiceo uo??a o ia??iae ?aiiueiai iioiaaiaco caeeoa?oueny e aein? iac’yniaaiei. Io?eiai? aeai? na?ae/aoue, ui aetheiei?oeei?aeiee aeenaaeain o i?aiaoaeueiee ia??iae, yeee aeieea? aiane?aeie aaaaeaiiy a?ae?iei?oeciio naieai i?ioyaii inoaiiueiai oeaeiy aaa?oiino?, i?ecaiaeeoue aei cieeiaiiy noaoaaeo a?aei?iiinoae ai?noo oa ia?ao IA o i?aiioe/i?e ae?eyioe? ? aiaeii/an i?enei?th? iaoaaie?/iee ia?a NO o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? ia?aaaaeii o naiie o ia??iae ?aiiueiai iioiaaiaco (oaae. 1). Noeoii?noue iaea?aeaieo aeaieo i?i ?iaeoeiaai? i?aiaoaeueiei no?anii oa aetheiei?oeei?aeiei aeenaaeainii o ia??iae aioo??oiueioo?iaiiai ?icaeoeo ii?ooaiiy noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie iiceo na?ae/eoue i?i oa, ui aiie ?aae?cothoueny ca aeiiiiiaith ni?eueieo, iiina?aaeeiaaieo aetheiei?oeei?aeaie iaoa??, iaoai?ci?a. Aeiaeaoeiao i?aenoaao aeey oeueiai aeniiaeo aea? oie oaeo, ui ?iceaaee noaoaai? iiaaae?iee, ni?e/eiai? i?aiaoaeueiei no?anii, iiaeooue aooe onoiai? aae?aiaeaeoii??th iaoa?? i?ae /an aaa?oiino? [F. Gotz et al., 1986; E.I. Ianeiaa, A.A. Iaoiaiei, 1990]. ?nio? aeae?eueea iiaeeeaeo iaoai?ci?a ia?eiaoaeueii? iiaeeo?eaoe?? iiiiai?ia?a?/ii? nenoaie iiceo o iauaaee?a i?ae aieeaii iaoa?einueeiai no?ano. Iaeei c ieo iia’ycaiee ?c ci?iaie aeoeaiino? eeth/iaiai oa?iaioo neioaco EA oe?iceia?ae?ieneeace, ui aeieeathoue aiane?aeie ca?eueoaiiy ??aiy aetheiei?oeei?ae?a o ieiaea no?aniaaieo aaa?oieo naiie uo??a [I.I. Aeuaaei e ae?., 1991; O.N. Eaeeieia, I.I. Aeuaaei, 1991]. C ?ioiai aieo, ii?ooaiiy noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie iiceo i?ae aieeaii i?aiaoaeueiiai no?ano iiaea aooe ni?e/eiaii cieaeaiiyi ??aiy O o e?ia? ieiaea ? iiaiia?iaeaeaieo naioe?a [F. Stahl et al., 1978; I.Ward, J. Weisz, 1980, 1984], ui a naith /a?ao coiiaeth? ciaioaiiy a?iiaoacii? aeoeaiino? o a?iioaeaion? ieiae?a ? iiaiia?iaeaeaieo iauaaee?a [J. Weisz et al., 1982; I.A. ?aci?eia ? ni?aaao. 1996; A. Reznikov et al., 1997]. Oea oaa?aeaeaiiy ocaiaeaeo?oueny ?c iaoeie niinoa?aaeaiiyie a?aeiinii iayaiino? ca’yceo i?ae ai?noii EA oa a?iiaoecaoe??th aiae?iaai?a o a?iioaeaion?, ui ?icaeaa?oueny. Iaeiei ?c caaaeaiue aeine?aeaeaiue aoei aea/aiiy ii?oieia?/ieo ci?i o naen-aeeii?oieo ae?eyieao iiceo, aea niinoa??aaeeny iae?io?i?/i? ci?ie. Iae/?oe?o? noaoaa? a?aei?iiino? aoee aeyaeai? o noi?ao?aciaoe/ieo yae?ao (NOss) a?iioaeaiona 10-aeaiieo uo??a. O naioe?a ia’?i yaea? iae?ioeeo?a NOss aoa a?eueoee, i?ae o naiie (?en. 6 A). ?en. 6. *anoioiee ?iciiae?e ia’?io yaea? iae?ioeeo?a noi?ao?acia-oe/ieo yaea? a?iioaeaiona o ?ioaeoieo (A) oa i?aiaoaeueii no?ani-aaieo (A) uo??a 10-aeaiiiai a?eo. I?ei?oee. Ii in? i?aeeiao - e?euee?noue iae?ioeeo?a, ii in? aanoeen- ia’?i yaea?, iei3. E?i?y c o?eeooieeaie - naioe?, e?i?y c eaaae?aoaie - naiee. Aeaye? aaoi?e a?aecia/athoue, ui NOss naen-aeeii?oi? ia o?eueee uiaei ia’?io yaea? iae?ioeeo?a, aea e a?aeiinii i?enooiino? iae?io?i?/ieo ?a/iaei o ee?oeiieo o?eao iae?ii?a oeeo yaea?, a oaeiae o aieieiao, ye? ?iia?aothoue yae?a [R. Simerly et al., 1985; S. Breedlove, 1992]. A?aoiaoth/e aeai? e?oa?aoo?e, a oaeiae ?acoeueoaoe iaoeo aeine?aeaeaiue noiniaii oi?ioaaiiy noaoaaeo a?aei?iiinoae ai?noo oa ia?ao IA o i?aiioe/i?e ae?eyioe? o ia??iae ?aiiueiai iioiaaiaco, iiaeia i?eionoeoe iaaiee ca’ycie oeeo ci?i ?c noaoaaei aeeii?o?ciii o no?oeoo?? NOss o oeae ia??iae NAeI. Oea i?eiouaiiy iaea?aeaei nai? i?aeoaa?aeaeaiiy o aeine?aeao ia iiaeae? i?aiaoaeueiiai no?ano. I?ae aieeaii i?aiaoaeueiiai no?ano a?aeaoaa?oueny i?aaethaaiiy noaoaaeo a?aei?iiinoae o NOss ca ?aooiie ciaioaiiy ia’?io yaea? iae?ioeeo?a o i?aiaoaeueii no?aniaaieo naioe?a aei ??aiy, i?eoaiaiiiai naieai (aeea. ?en. 5 A). Oea ei?aeth? c /?oeeie ci?iaie ai?noo oa ia?ao IA o i?aiioe/i?e ae?eyioe? i?aiaoaeueii no?aniaaieo naioe?a. Oaea iaiiaia ianeoe?i?caoe?y naen-aeeii?oii? ae?eyiee iiceo iiaea aooe coiiaeaia aaeuei?aiei aieeaii i?aiaoaeueiiai no?ano ia oanoeeoey?io nae?aoe?th O ieiaea oa iiaiia?iaeaeaiiai. Oyaeaiiy i?i caeaoi?noue i?aiaoaeueiiai no?ano aieeaaoe ia iicie naiie uo??a ia ??ai? iaae?iaacaeueiiai a?iioaeaiona, ye? neeaeeny aiane?aeie iae?io?i?/iiai aiae?co ai?noo oa ia?ao AeA o oe?e ae?eyioe? iiceo, ae?noaee i?aeoaa?aeaeaiiy o iii??ieo ci?iao ia’?io yaea? iae?ioeeo?a a?eoaoiiai yae?a iaae?iaacaeueiiai a?iioaeaiona i?aiaoaeueii no?aniaaieo naiie, ui ocaiaeaeo?oueny ?c iacia/ieie ii?ooaiiyie oaciai? no?oeoo?e ano?aeueieo oeeee?a o aei?ineeo oaa?ei. Oaeei /eiii, ?acoeueoaoe aeine?aeaeaiue aeaiiino?othoue caeo/aiiy iiiiai?ia?a?/ieo nenoai iiceo a ai?iiiaeuei? ?ii?eioeiaia? iaoai?cie iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe??. Aeiaaaeaii, ui ii?ooaiiy noaoaai? aeeoa?aioe?aoe?? iiiiai?ia?a?/ieo nenoai o naen-aeeii?oieo ae?eyieao aieiaiiai iiceo aiane?aeie i?aiaoaeueiiai no?ano oa ai?iiiaeueiiai aeenaaeaino iiaea aeaoa?i?ioaaoe ?icaeoie iae?iaiaeie?eiii? iaoieia?? ?ai?iaeoeoeaii? iiaaae?iee oa nae?aoe?? aiiaaeio?iiieo ai?iii?a o aei?ineeo oaa?ei. ? i?aenoaae aaaaeaoe, ui o i?aea?oio? a?aeaeaeaieo iane?aee?a ia?eiaoaeueieo ai?iiiaeueieo oa no?aniaeo aieea?a ia iae?iaiaeie?eiio nenoaio ?aaoeyoe?? ?ai?iaeoeoe?? eaaeaoue ii?ooaiiy ai?iii-iaae?aoi?ieo aca?iia?aeiinei o ia??iae ?aiiueiai iioiaaiaco. Aieea no?ano iaoa?einueeiai i?aai?cio ia noaoaa? oa a?eia? iniaeeaino? no?an-?aaeoeaiino? a?iioaeaii-a?iio?ca?ii-iaaeie?eiai? nenoaie o iauaaee?a uo??a Aaaeeeaei e?eoa???i o?c?ieia?/ii? cia/eiino? iioiaaiaoe/ieo /eiiee?a o ?ii?eioeiaia?e iiaeeo?eaoe?? ooieoe?e iiceo ? ci?ie aaeaioaoe?eieo i?ioean?a o aei?ineeo oaa?ei. A?aeiii, ui iaei??th c i?e/ei ii?ooaiiy no?an-?aaeoeaiino? AAIN aei?ineeo oaa?ei, ye? caciaee aieeao no?ano aai aetheiei?oeei?aeieo ai?iii?a o ia?eiaoaeueiee ia??iae, ? ci?ie aeoeaiino? oe?iceia?ae?ieneeace o iiceo ieiaea [I.I. Aeuaaei e ae?., 1991]. A?aoiaoth/e ?acoeueoaoe iaoeo aeine?aeaeaiue, ca?aeii c yeeie no?ani?i? oa ai?iiiaeuei? /eiieee o ia?eiaoaeueiee ia??iae aieeaathoue ia aeic??aaiiy EA-a?a?/ii? nenoaie iiceo, oe?eeii i/?eoaaiei aoei aeyaeaiiy ci?i no?an-?aaeoeaiino? AAIN . Iane?aeeii oeeo aeine?aeaeaiue aoei c’ynoaaiiy noaoaaeo iniaeeainoae ?aaeoe?? AAIN ia aino?ee no?an o ii?i? oa i?ney i?aiaoaeueiiai no?ano. Ca?aeii c aeaieie e?oa?aoo?e [R. Handa et al., 1994; C. McCormick et al., 1995; V. Patchev et al., 1995] noaoaa? a?aei?iiino? ?aaeoe?? AAIN ia no?ania? noeioee anioe?eiaai? c iayai?noth noaoaaeo ai?iii?a. Io?eiai? aeai? na?ae/aoue, ui no?an iaoa?? i?ioyaii inoaiiueiai oeaeiy aaa?oiino? ni?e/eith? ci?ie no?aniai? ?aaeoe?? AAIN o iauaaee?a, ye? niinoa??aathoueny ai?iaeiaae anueiai ?oiueiai aeeooy. I?e oeueiio naiee uo??a ?aaaoaaee ia i?aiaoaeueiee no?an iaioith i??ith ii??aiyii c naioeyie. Ia?aeiieeaith ?ethno?aoe??th aei oeueiai iieiaeaiiy ? caa?aaeaiiy ? iaa?oue iii??ia iineeaiiy no?aniai? aae?aiiei?oeeaeueii? ?aaeoe?? o aei?ineeo i?aiaoaeueii no?aniaaieo naiie uo??a (?en. 7). ?en. 7. ??aaiue ei?oeeinoa?iio (11-IEN) o ieaci? e?ia? ?ioaeoieo oa i?aiaoaeueii no?aniaaieo naioe?a ? naiie uo??a 3-i?ny/iiai a?eo, ye? caciaee aino?iai no?ano i?ioyaii 1 aiae. I?ei?oea. ??cieoey a??ia?aeia *P<0,05 ii??aiyii c aacaeueiei ??aiai (na?oe? noiai/eee). Iii??ia iineeaiiy aae?aiiei?oeeaeueii? ?aaeoe?? ia aino?ee no?an o aei?ineeo i?aiaoaeueii no?aniaaieo naiie iiaeia aoei a iiynieoe noeioethth/ei aieeaii ano?iaai?a ia nae?aoe?th AEOA ? EN. I?aeaeuaiiy nae?aoi?ii? aeoeaiino? iaaeie?eiai? eaiee AAIN iiaea aooe iane?aeeii ye i?yii? ae?? ano?iaai?a ia nae?aoe?th ei?oeeio?iiei-?ee?c?ia-ai?iiio [N. Vamvakopoulos, G. Chrousos, 1993], oae ? iineeaiiy /ooeeaino? aaeaiia?iio?ca aei ei?oeeio?iiei-?ee?c?ia-ai?iiio [M. Coyne, J. Kitay, 1971]. Ca ?acoeueoaoaie iaoeo aeine?aeaeaiue, ??aaiue ano?aae?ieo o ieaci? e?ia? i?aiaoaeueii no?aniaaieo naiie, ye? ia?aaoaaee o noaae?? ae??no?ono, ia a?ae??ciyany a?ae eiio?ieueieo iieaciee?a ? neeaaeaa 151, 08 13,18 iiieue/e i?e 124, 7825, 51 iiieue/e o eiio?ieueieo oaa?ei. Ca oeeo ianoaaei aa?oi caa?iooe oaaao ? ia ?io? iiaeeea? iaoai?cie iineeaiiy nae?aoe?? EN. Iaeei ?c ieo iia’ycaiee ?c cieaeaiiyi u?eueiino? EN ?aoeaioi??a o a?iieaii?, ui ca iaoai?ciii iaaaoeaiiai cai?ioiueiai ca’yceo iiaea i?ecaiaeeoue aei iinono?ani?ii? a?ia?nae?aoe?? EN [L. Jacobson, R. Sapolsky, 1991]. Iaaaeyea cia/aiiy iiaea iaoe i?aeaeuaiiy nae?aoe?? i?ieaeoeio a oiiaao no?ano, yeee, ye a?aeiii, iiceoeaii aieeaa? ia ei?oeeinoa?i?aeiaaiac ? iiina?aaeeiao? ae?th ano?iaai?a ia aae?aiiei?oeeioeeoe [TH.TH. Naoo?i oa ni?aaao., 1996; TH.TH. Naoo?i, 1997]. Ia a?aei?io a?ae naiie, o aei?ineeo i?aiaoaeueii no?aniaaieo naioe?a ai?iiiaeueia a?aeiia?aeue iaaeie?eiaeo caeic ia aino?ee ?iiia?e?caoe?eiee no?an aoea cia/ii ineaaeaiith (aeea. ?en. 7), ui iiaea aooe coiiaeaii cieaeaiiyi ?aaeoeai?no? aaeaiia?iio?ca. Oea ocaiaeaeo?oueny ?c ?acoeueoaoaie ii?oieia?/ieo aeine?aeaeaiue, ye? na?ae/aoue i?i cao?eieo aeaaaeaiiy nae?aoi?ieo a?aioe AEOA ?c ei?oeeio?iiioeeo?a aaeaiia?iio?ca o oeeo oaa?ei. Ciaioaiiy aae?aiiei?oeeaeueii? ?aaeoe?? ia no?aniaee noeioe o i?aiaoaeueii no?aniaaieo naioe?a iiaeia iiynieoe ii?ooaiiyi oeaio?aeueieo EA-a?a?/ieo iaoai?ci?a, yea i?iyaeeiny o iiai?e a?aenooiino? ?aaeoe?? IA a?iioaeaiona ia aino?ee no?an (?en. 8). ?en. 8. Ai?no ii?aae?aiae?io a a?iioaeaion? ?ioaeoieo oa i?aiaoaeueii no?aniaaieo naioe?a ? naiie uo??a 3-i?ny/iiai a?eo, ye? caciaee aino?iai no?ano i?ioyaii 1 aiae. I?ei?oea. ??cieoey a??ia?aeia *P<0,05 ii??aiyii c aacaeueiei ??aiai (na?oe? noiai/eee). Cieaeaiiy iinono?ani?ii? nae?aoe?? EN o aei?ineeo naioe?a iiaeia ?icaeyaeaoe ye iane?aeie ?aii?o iinoiaoaeueieo ci?i EA-a?a?/ii? aeoeaiino? a?iioaeaiona, coiiaeaieo no?an-?iaeoeiaaiei aeenaaeainii o i?aiaoaeueiee ia??iae. Oaeei /eiii, io?eiai? aeai? aeathoue ciiao ae?eoe aeniiaeo, ui o aei?ineeo naioe?a ooeiaeaeoth/ee aieea i?aiaoaeueiiai no?ano ?aae?co?oueny ia ??ai? oeaio?aeueieo iaoai?ci?a ?aaoeyoe?? no?an-?aaeoeaiino? AAIN. ?acoeueoaoe iiaeaeueoeo aenia?eiaio?a aeiaaee iaaiee iiaeeo?eoth/ee aieea i?aiaoaeueiiai no?ano ia a?eia? ci?ie no?an-?aaeoeaiino? AAIN o uo??a iaio noaoae (oaae. 2). Oaaeeoey 2 Ai?no eaoaoieai?i?a o a?iioaeaion? oa ??aaiue ei?oeeinoa?iio a ieaci? e?ia? o noa?eo ?ioaeoieo oa i?aiaoaeueii no?aniaaieo naioe?a ? naiie uo??a, ye? caciaee aino?iai no?ano i?ioyaii 1 aiae ( I m, n = 6 ) Aenia?eiaioaeuei? Eaoaoieai?ie, iiieue/a oeaieie Ei?oeeinoa?ii, oiiae Ii?aae?aiae?i Aeioai?i iiieue/eNaioe??ioaeoi?:aei aino?iai no?ano 3,99 0,13 2,74 0,18 817,9 134,5i?ney no?ano2,46 0,22* (a) 2,89 0,36 930,3 171,8I?aiaoaeueii no?aniaai?:aei aino?iai no?ano3,45 0,19* (a) 4,10 0,16* (a) 577,4 103,1i?ney no?ano2,85 0,19* (a) 3,13 0,35 1154,8 153,4* (a)Naiee?ioaeoi?:aei aino?iai no?ano4,28 0,70 3,67 0,48 1336,6 302,9i?ney no?ano3,02 0,11 2,70 0,23 2557,6 259,2* (a)I?aiaoaeueii no?aniaai?:aei aino?iai no?ano3,47 0,24 3,27 0,19 1390,7 155,5i?ney no?ano3,29 0, 29 3,20 0,31 2343,8 252,3* (a)I?ei?oee. ??cieoey aeinoia??ia * P<0,05 (U-oano) ii??aiyii: a - c a?oiith ?ioaeoieo oaa?ei aei aino?iai no?ano; a - c a?oiith i?aiaoaeueii no?aniaaieo oaa?ei aei aino?iai no?ano Io?eiai? aeai? na?ae/aoue i?i iayai?noue cia/ieo noaoaaeo a?aei?iiinoae o /ooeeaino? oeaio?aeueieo oa ia?eoa??eieo eaiie AAIN aei no?aniaeo noeioe?a o noa?eo uo??a o ii?i? oa ca oiia i?aiaoaeueiiai no?ano. I?ae aieeaii i?aiaoaeueiiai no?ano o noa?eo naioe?a caa??aaeanue ai?iiiaeueia a?aeiia?aeue ei?e iaaeie?eiaeo caeic ia aino?ee no?an ia ??ai? aei?ineeo ?ioaeoieo uo??a (aeea. oaae. 2). Io?eiai? aeai? ocaiaeaeothoueny c ?acoeueoaoaie ii?oieia?/ieo aeine?aeaeaiue, ye? na?ae/aoue i?i iciaee iai?oaeaiiy no?oeoo?ii-ooieoe?iiaeueieo ?aca?a?a a?iio?ca?ii-iaaeie?eiai? nenoaie, ui iiaea aooe nei??oa iia’ycaii ?c aeoea?caoe??th nae?aoe?? ai?iii?a, a ia ?c noeioeyoe??th a?ineioaoe/ieo i?ioean?a. Ia a?aei?io a?ae naioe?a, o noa?eo naiie a?aecia/aii cieaeaiiy aaeaioeaieo iiaeeeainoae EA-a?a?/ii? nenoaie a?iioaeaiona (aeea.oaae. 2). A?aenooi?noue no?aniaeo ci?i ??aiy IA o a?iioaeaion? ?ioaeoieo oa i?aiaoaeueii no?aniaaieo oaa?ei niinoa??aaeanue ia oe? cieaeaiiy aeoeaiino? oeaio?aeueii? EA-a?a?/ii? nenoaie o noa?eo naiie ii??aiyii c aei?ineeie oaa?eiaie, ui iiaea ?icaeyaeaoeny ye caoenia ?aaeoe?y ia aeniaaeaiiy ia?aiaeo ee?oei aieiaiiai iiceo a oiiaao no?ano. ?acii ?c oei, o ia??iae noa??iiy o naiie caa??aaeanue caeaoi?noue iaaeie?eiai? eaiee AAIN ?aaaoaaoe ia aino?ee no?an, yea aeanoeaa aei?ineei oaa?eiai (aeea. oaae. 2). I?e oeueiio aenieee ??aaiue no?aniai? ai?iiiaeueii? ?aaeoe?? o noa?eo naiie ia ci?ithaaany i?ae aieeaii i?aiaoaeueiiai no?ano. Aeai? noiniaii i?ci?oiai caanaiiy /ooeeaino? ei?e iaaeie?eiaeo caeic aei no?ano o noa?eo naiie uo??a oe?eeii ocaiaeaeothoueny c ?nioth/ith oi/eith ci?o, ui aaeaioeai? nenoaie o naiie uo??a iathoue a?eueo? ?aca?ae ii??aiyii ?c naioeyie. Oaeei /eiii, ? i?aenoaae aaaaeaoe, ui aieea i?aiaoaeueiiai no?ano ia no?an-?aaeoeai?noue AAIN o naioe?a ? naiie uo??a ?aae?cothoueny ??cieie naen-niaoeeo?/ieie iaoai?ciaie. O aeine?aeao ?c aeei?enoaiiyi oanoo aoiie anoaiiaeaii, ui i?ae aieeaii i?aiaoaeueiiai no?ano o aei?ineeo oaa?ei cieaeothoueny o?ce/i? ?aca?ae i?aai?cio, oi/a e caa??aathoueny noaoaa? a?aei?iiino? (?en. 9). ?en. 9. Aieea i?aiaoaeueiiai no?ano ia ?icaeoie o?ce/ii? aoiie o naioe?a ? naiie uo??a ??ciiai a?eo. I?ei?oee. ??cieoey a??ia?aeia *P<0,05 ii??aiyii c naioeyie (oaii? noiai/eee). ?icaeoie o?ce/ii? aoiie ioe?ithaaee ca /anii (nae) oo?eiaiiy oaa?ei ia aa?oeeaeuei?e aea?aeei?. O ii?i? o?ce/ia aeo?eaae?noue ca oanoii noiieaiiy o aei?ineeo naiie cia/ii aeua, i?ae o naioe?a. Ca oiia caa?aaeaiiy noaoaaeo a?aei?iiinoae i?aiaoaeueiee no?an ni?e/eith? i?aeaeuaio noiiethaaii?noue o aei?ineeo naiie uo??a. A i?ioean? noa??iiy o uo??a ia oe? oaeaeeiai ?icaeoeo o?c?/ii? aoiie a?aeaoaa?oueny i?aaethaaiiy ye noaoaaeo a?aei?iiinoae, oae ? aoaeo?a i?aiaoaeueiiai no?ano. A?aeaeaeai? iane?aeee aieeao i?aiaoaeueiiai no?ano ia ?ai?iaeoeoeaio ooieoe?th naiie uo??a C e?oa?aoo?e a?aeiii, ui a ia??iae aioo??oiueioo?iaiiai ?icaeoeo ieiaee ae?ii/i? noao? iaio o?aceea? aei no?aniaeo aieea?a, i?ae naioe?. I?ioa, ye iieacaee aeine?aeaeaiiy, ? o naiie uo??a, no?aniaaieo o i?aiaoaeueiee ia??iae, caiaeii niinoa??aathoueny iciaee iaoieia?? ?ai?iaeoeoeaii? nenoaie. O i?aiaoaeueii no?aniaaieo uo??a a?aee?eooy i?oae a?aeaoaaeinue a na?aaeiueiio ia 7 ae?a i?ci?oa, i?ae o ?ioaeoieo oaa?ei ( ?ioaeoi?: 42,4 0,4 aeiae; i?aiaoaeueii no?aniaai?: 49,7 1,1 aeiae; ?<0,001). I?e aeinyaiaii? 3-i?ny/iiai a?eo o oeeo oaa?ei niinoa??aaee ia?aaoey?i? oeeeee c ii?ooaiiyie oaciai? no?oeoo?e oa ca?eueoaiiyi o?eaaeino? ano?aeueieo oeeee?a. Oae, yeui o ?ioaeoieo uo??a o?eaae?noue noaae?? ano?ono noaiiaeea 15,8 %, a ae?ano?ono - 40,6 %, oi o noaoaaic??eeo i?aiaoaeueii no?aniaaieo naiie niinoa??aaeeny ci?ie oaciai? no?oeoo?e oeeeeo ia?aaaaeii ca ?aooiie ca?eueoaiiy o?eaaeino? noaae?? ae?ano?ono (58,2 %) ? iaioith i??ith ca ?aooiie ca?eueoaiiy o?eaaeino? noaae?? ano?ono (26,5 % ). O i?aiaoaeueii no?aniaaieo naiie a?eii 3 i?n o noaae?? ae?ano?ono a?aeiinia iana y?/iee?a ia ci?ithaaeanue, a iaoee - ciaiooaaeanue ii??aiyii c eiio?ieai. ??aaiue ano?aae?ieo o oeeo i?aeaeine?aeieo uo??a aoa ia ??ai? eiio?ieueieo aaee/ei. O i?aiaoaeueii no?aniaaieo naiie uo??a 5-, 7- ? 9-i?ny/iiai a?eo ci?ie oaciai? no?oeoo?e ano?aeueieo oeeee?a a?aeiinii aiaeia?/ieo iieaciee?a o ?ioaeoieo oaa?ei a?aeiia?aeiiai a?eo aoee iaio ae?aaeaieie. Aeine?aeaeaiiy noaoaai? oeeee?/iino? o naiie uo??a o a?eueo a?aeaeaeai? ia??iaee aeeooy (12-, 14-, 16- , 18-, 20 -, 22-i?n ia aeyaeei ?noioieo a?aeoeeaiue o no?oeoo?? oa o?eaaeino? ano?aeueieo oeeee?a ii??aiyii c a?aeiia?aeieie a?eiaeie a?oiaie ?ioaeoieo oaa?ei. O i?aiaoaeueii no?aniaaieo naiie o noaae?? ae?ano?ono a?eii 21 i?n a?aeiinia iana y?/iee?a oa iaoee ?noioii ia ci?ithaaeanue ii??aiyii c eiio?ieueieie oaa?eiaie oiai ae a?eo . Oaeei /eiii, i?aenoiiaoth/e ?acoeueoaoe aeine?aeaeaiue, iiaeia ae?eoe aeniiaeo, ui ii?ooaiiy ?ii?eioeiaiaeo iaoai?ci?a aiane?aeie ia?eiaoaeueieo no?ani?ieo oa ai?iiiaeueieo ae?yiue aeaoa?i?io? o?eaae? ci?ie iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe?? oa no?an-?aaeoeaiino? AAIN. Oe? ooieoe?iiaeuei? ?iceaaee iathoue aeiaaino?ieiaee oa?aeoa?, a ?oiy ni?yiiaai?noue oa ae?aci?noue caeaaeaoue a?ae noao? oaa?ei. AENIIAEE 1. Aecia/aii ?ieue noa?i?aeieo ai?iii?a ? a?iaaiieo iiiiai?i?a iiceo a oi?ioaaii? ooieoe?iiaeueieo ?iceaae?a ?ai?iaeoeoe?? (aiiaoeyoi?ia iaie?aei?noue) oa no?an-?aaeoeaiino? (neiae?ii i?aiaoaeueiiai no?ano), ye? aeieeathoue aiane?aeie ai?iiiaeueieo oa no?ani?ieo aieea?a ia aieiaiee iicie o ia?eiaoaeueiee ia??iae ?iaeea?aeoaeueiiai ?icaeoeo. 2. ?aii?ie i?iyaaie ii?ooaiue ai?iiiaeueiiai ?ii?eioeiao aieiaiiai iiceo o iaiiaoaeueii aiae?iaai?ciaaieo naiie uo??a ? i?aeaeuaiiy ai?noo oa ia?ao eaoaoieai?i?a o iaae?iaacaeueiiio a?iioaeaion? oa iineeaiiy iaoaaie?cio na?ioii?io o i?aiioe/i?e ae?eyioe?. Oe? ci?ie ? iiaeeeaeie /eiieeaie ii?ooaiue oeeee?/ii? nae?aoe?? aiiaaeio?iiieo ai?iii?a oa noaoaai? iiaaae?iee o aei?ineeo aiae?iaai?ciaaieo oaa?ei. 3. Iaoiaaiia (aeaoai?i?coth/a oa/aai ianeoe?i?coth/a) ae?y aeciaaiieo aiae?iaai?a ia iae?iaiaeie?eii? no?oeoo?e, ye? ?aaoeththoue noaoaao oeeee?/i?noue o naiie uo??a, iiina?aaeeiao?oueny i?iaeoeoaie a?iiaoecaoe?? oanoinoa?iio oa a?ae?ieneethaaiiy eiai ano?iaaiieo iaoaaie?o?a - eaoaoieano?iaaiaie. Iaoai?ci ?aae?caoe?? oeueiai aieeao iia’ycaiee ?c noeioeyoe??th iaeiie/aiiy ii?aae?aiae?io o a?iioaeaion? o e?eoe/iee ia??iae noaoaai? aeeoa?aioe?aoe?? iiceo. 4. Eaoaoieano?iaaie, ? ianaiia?aae 4-a?ae?ieneano?aae?ie-17 - i?e?iaei?e iaoaaie?o oanoinoa?iio o aieiaiiio iiceo - ? oeie noa?i?aeieie /eiieeaie, ui ni?e/eiththoue c?inoaiiy eiioeaio?aoe?? ii?aae?aiae?io o a?iioaeaion? i?ae aieeaii iaiiaoaeueii? aiae?iaai?caoe?? i?ae /an noaoaai? aeeoa?aioe?aoe?? iiceo. Oeae aoaeo cae?enith?oueny /a?ac aaeueioaaiiy iaoaaie?/ii? ?iaeoeaaoe?? eaoaoieai?i?a ca o/anoth eaoaoie-I-iaoeeo?ainoa?ace ? ei?aeth? ?c caeaoi?noth 4-a?ae?ieneano?aae?ieo-17 a?aeoai?thaaoe aoaeoe iaiiaoaeueii? aiae?iaai?caoe?? uiaei ?icaeoeo aiiaoeyoi?ii? iaie?aeiino? o aei?ineeo oaa?ei. 5. Aiae?iaaicaeaaeia aeeooa?aioe?aoe?y a?iioaeai?/iiai eiio?ieth nae?aoe?? aiiaaeio?iiieo ai?iii?a cae?enith?oueny aiane?aeie ii?aeiaiiai aieeao eaoaoieai?i?a oa ano?iaaiieo iaoaaie?o?a ca iaoai?ciii ei?iaeoeoe??. 6. ?iiia?e?caoe?eia no?anoaaiiy naiie uo??a i?ioyaii inoaiiueiai oeaeiy aaa?oiino? ia?aoeiaeaea? oi?ioaaiith noaoaaiai aeeii?o?cio ai?noo oa ia?ao eaoaoieai?i?a o i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? 10-aeaiieo iauaaee?a ca ?aooiie cieaeaiiy ia?ao ii?aae?aiae?io o i?aiioe/i?e ae?eyioe? naioe?a ? i?aeaeuaiiy ai?noo oa ia?ao aeioai?io o iaae?iaacaeueiiio a?iioaeaion? naiie. I?ae aieeaii i?aiaoaeueiiai no?ano iineeth?oueny iaoaaie?ci na?ioii?io o i?aiioe/i?e ae?eyioe? naiie ? iaae?iaacaeueiiio a?iioaeaion? naioe?a. 7. Ii?oieia?/iei i?iyaii aieeao i?aiaoaeueiiai no?ano ia i?ioean noaoaai? aeeoa?aioe?aoe?? iiceo ? cieeiaiiy noaoaaeo a?aei?iiinoae ia’?io yaea? iae?ioeeo?a noi?ao?aciaoe/ieo yaea? a?iioaeaiona ca ?aooiie ?o ciaioaiiy o naioe?a. Oe? ci?ie, ?acii ?c ii?ooaiiyi noaoaaiai aeeii?o?cio iiiiai?ia?a?/ii? nenoaie iiceo aiane?aeie i?aiaoaeueiiai no?ano, iiaeooue aooe ?aii?ie i?iyaaie aeaianeoe?i?caoe?? oa/aai oai?i?caoe?? noaoaai? iiaaae?iee o naioe?a oa ?iceaae?a noaoaai? oeeee?/iino? o naiie i?e aeinyaiaii? noaoaaic??eiai a?eo. 8. Aaaaeaiiy a?ae?iei?oeciio aaa?oiei naieai a?aeoai?th? aoaeoe i?aiaoaeueiiai no?ano noiniaii ?aii?o iinoiaoaeueieo ci?i ai?noo oa ia?ao ii?aae?aiae?io ? na?ioii?io o i?aiioe/i?e ae?eyioe?, ui na?ae/eoue i?i iiina?aaeeiaai? aetheiei?oeei?aeaie iaoa?? iaoai?cie ?icaeoeo ii?ooaiue iiiiai?ia?a?/ieo nenoai aieiaiiai iiceo a ia??iae ?aiiueiai iioiaaiaco. 9. Aieea i?aiaoaeueiiai no?ano ia no?an-?aaeoeai?noue AAIN o aei?ineeo ? noa?eo oaa?ei ?aae?co?oueny ca ?aooiie iaoai?ci?a, ye? caeaaeaoue a?ae noao?. I?aiaoaeueiee no?an iineaaeth? no?ani?io ?aaeoe?th a?iio?ca?ii-iaaeie?eiai? eaiee AAIN o aei?ineeo naioe?a, ui coiiaeaii ii?ooaiiyi i?ioeano aea?eueiaiiy ii?aae?aiae?io o a?iioaeaion? o a?aeiia?aeue ia aino?ee no?an. O i?aiaoaeueii no?aniaaieo naiie ca oiia caa?aaeaiiy ?aaeoe?? ii?aae?aiae?io a?iioaeaiona ia aino?ee no?an iii??ii iineeth?oueny ai?iiiaeueia a?aeiia?aeue ei?e iaaeie?eiaeo caeic . 10. I?ae /an noa??iiy o i?aiaoaeueii no?aniaaieo naiie uo??a cieaeo?oueny no?an-?aaeoeai?noue eaoaoieai?iiai? nenoaie a?iioaeaiona, i?ioa caa??aa?oueny aae?aiiei?oeeaeueia ?aaeoe?y ia no?ania? noeioee, ui na?ae/eoue i?i a?eueo i?ci? caanaiiy aaeaioeaieo iaoai?ci?a. O noa?eo i?aiaoaeueii no?aniaaieo naioe?a caa??aa?oueny caeaoi?noue eaoaoieai?i?a a?iioaeaiona oa ei?e iaaeie?eiaeo caeic ?aaaoaaoe ia aino?ee no?an ia ??ai? ii?iaeueieo aei?ineeo oaa?ei. 11. O ii?i? o?ce/ia aeo?eaae?noue ca oanoii noiieaiiy o aei?ineeo naiie cia/ii aeua, i?ae o naioe?a. Ca oiia caa?aaeaiiy noaoaaeo a?aei?iiinoae i?aiaoaeueiee no?an ni?e/eith? i?aeaeuaio noiiethaaii?noue o aei?ineeo naiie uo??a. I?ae /an noa??iiy o ii?iaeueieo ? i?aiaoaeueii no?aniaaieo uo??a oe? noaoaa? ?ica?aeiino? cieeathoue ia oe? a?eueo cia/iiai cieaeaiiy o?ce/iiai ?aca?ao o naiie. 12. Eaoaoieai?ie a?iioaeaiona ? ni?eueiith eaieith a iaoiaaiac? ii?ooaiue noaoaai? aeeoa?aioe?aoe?? iiceo, ye? aeieeathoue ye aiane?aeie no?ani?ieo aieea?a o ia??iae aioo??oiueioo?iaiiai ?icaeoeo i?aai?cio (neiae?ii i?aiaoaeueiiai no?ano), oae ? ai?iiiaeueiiai aeenaaeaino o iiaiia?iaeaeaieo oaa?ei (aiiaoeyoi?ia iaie?aei?noue). IA?AE?E INIIAIEO IOAE?EAOe?E II OAI? AeENA?OAOe?? 1. Iinaiei I.Ae. Aeeyiea eiaeaeoi?ia N19-noa?ieaeia ia aicieeiiaaiea aiiaoeyoi?iie noa?eeueiinoe o iaiiaoaeueii aiae?iaaiece?iaaiiuo naiie e?un // Aeieeaaeu AI ONN?. - 1982. - ?8. - N.76-79. 2. Reznikov A.G., Nosenko N.D. It is possible noradrenaline the biogenic monoamine responsible for androgen-dependent sexual brain differentiation // Endokrinologie. - 1983. - B. 81, H. 1. - S. 91-93. 3. Iinaiei I.Ae., ?acieeia A.A. Aeeyiea nenoaiiiai e eio?aoea?aa?aeueiiai aaaaeaiey eciia?ia eaoaoieano?iaaiia ia iieiaoth aeeooa?aioeeaoeeth iicaa // Aeieeaaeu AI ONN?. - 1986. - ?8. - N.71-73. 4. Iinaiei I.Ae., ?acieeia A.A. Aeeyiea eiaeaeoi?ia a?iiaoacu N19-noa?ieaeia ia niaea?aeaiea eaoaoieaieiia a aeiioaeaiona iaiiaoaeueii aiae?iaaiece?iaaiiuo e?un // Athe. yenia?ei. aeie. iaae. - 1987. - ?5. - N.546-548. 5. Reznikov A.G., Nosenko N.D. Prevention of the anovulatory syndrome and testosterone - induced rise in catecholamine level in the hypothalamus of newborn rats with steroid aromatase inhibitors // Exp. Clin. Endocrinol. - 1987. - Vol. 90, N.2. - P.185-189. 6. Iinaiei I.Ae. Iae?iyiaeie?eiiua yooaeou iaiiaoaeueiiai aicaeaenoaey eiaeaeoi?a eaoaoie-I-iaoeeo?ainoa?acu e iieiauo noa?ieaeia // I?iae. yiaeie?eiieiaee. - 1989. - O. 35, ?5. - N. 64-68. 7. Iinaiei I.Ae., ?acieeia A.A. Iiauoaiea niaea?aeaiey ii?aae?aiaeeia a aeiioaeaiona iiai?iaeaeaiiuo naiie e?un iiae aicaeaenoaeai 4-aeae?ieneyno?aaeeiea-17 // Athe. yenia?ei. aeie. iaae. - 1990. - ?6. - N. 555-556. 8. Reznikov A.G., Nosenko N.D. Some considerations on interrelation between catecholestrogens and catecholamines in androgen-dependent differentiation of the hypothalamuss // Neuroendocrinology: The New Frontiers. - Tubingen:Brain Research Production, 1990. - C. 97-103. 9. Reznikov A.G., Nosenko N.D., Tarasenko L.V. Augmentation of sterilizing effect of neonatal androgenization with tropolone, catechol-O-methyltransferase inhibitor, in female rats // Neuroendocrinology. - 1990. - Vol. 55. - P.455-459. 10. Iinaiei I.Ae., Ao?/eineay E.O., ?acieeia A.A. Yooaeou iaiiaoaeueiiai aicaeaenoaey 6-aeae?ieneaeioaieia e aiae?iaaicaaeneiay aeaoaieiecaoeey iicaa naiie e?un // Oeceie. aeo?i. - 1993. - O. 39, ?4. - N. 3-9. 11. ?acieeia A.A., Aa?aa N.A., Iinaiei I.Ae., Neieoeui I.A., Oa?anaiei E.A. Iaoioeceieiae/aneea iaoaieciu ia?ooaiee iae?iai?iiiaeueiie ?aaoeyoeee ?ai?iaeoeoeee i?e aiiaoeyoi?iii neiae?iia // Iae?iaoii?aeueiay ?aaoeyoeey a iaoieiaee. - Oa?ueeia:OAIO, 1994. - N. 108-111. 12. Reznikov A.G., Nosenko N.D. Catecholamines in steroid-dependent brain development // J. Steroid Biochem. Molec. Biol. - 1995. - Vol. 53, N 1-6. - P.349-353. 13. Iinaiei I.Ae. Iieiaie aeeii?oeci iiiiaieia?ae/aneie nenoaiu iicaa: yooaeou i?aiaoaeueiiai no?anna e iaiiaoaeueiie aiae?iaaiecoeee // Oeceie. aeo?i. ei. E.I. Na/aiiaa. - 1996. - O.82, ?4. - N.46-53. 14. Reznikov A.G., Nosenko N.D. Early postnatal changes in sexual dimorphism of catecholamine and indoleamine contents in the brain of prenatally stressed rats // Neuroscience. - 1996. - Vol. 70, N 2. - P.547-551. 15. ?aci?eia I.A., Iinaiei I.Ae., Oa?anaiei E.A N?i?oeei I.A., Iieyeiaa E.?. Iaoio?c?ieia?/i? iaoai?cie ii?ooaiue ?aaoeyoe?? ?ai?iaeoeoe?? oa aaeaioaoe?? aiane?aeie i?aiaoaeueiiai no?ano // Aiaeie?eiieia?y. - 1996. - O.1, ? 1. - N. 14-24. 16. ?acieeia A.A., Iinaiei I.Ae., Oa?anaiei E.A., Neieoeui I.A. Iae?iyiaeie?eiiua iaoaieciu iaoiaaiiiai aeeyiey i?aiaoaeueiiai no?anna ia nenoaiu ?ai?iaeoeoeee e aaeaioaoeee o e?un a oiaea iioiaaiaca // Iae?iaoii?aeueiua iaoaieciu iaoieiae/aneeo i?ioeannia. - Oa?ueeia:Oaeo, 1996. - N. 76-81. 17. Iinaiei I.Ae. Aeeyiea no?anna iaoa?eineiai i?aaiecia ia iai?io eaoaoieaieiia a iicao aeaoaiuoae e?un // Iae?ioeceieiaey. - 1997. - O. 29, ? 2. - N. 124-130. 18. Iinaiei I.Ae. Aeiaaino?ieia? ci?ie no?an-?aaeoeaiino? eaoaoieai?iiai? nenoaie a?iioaeaiona ? ei?e iaaeie?eiaeo caeic o i?aiaoaeueii no?aniaaieo naiie uo??a // Aiaeie?eiieia?y. - 1997. - O. 2, ? 1. - N.114-119. 19. Reznikov A.G., Nosenko N.D., Tarasenko L.V. Prenatal stress effects on catecholamine content and androgen metabolism in discrete brain regions of newborn rats // Aeiiia?ae? IAI Oe?a?ie. - 1997. - ? 4. - N.172-175. 20. ?aci?eia I.A., Iinaiei I.Ae., Oa?anaiei E.A., N?i?oeei I.A., Iieyeiaa E.?. Ii?oieia?/i? oa ooieoe?iiaeuei? ci?ie iae?iaiaeie?eiii? nenoaie o i?aiaoaeueii no?aniaaieo uo??a // Aoeiaeinueeee iaae. a?niee. - 1998. - O.2, ? 2. - N.47-51. 21. Reznikov A.G., Nosenko N.D., Tarasenko L.V. Prenatal stress and glucocorticoid effects on the developing gender-related brain // J. Steroid Biochem. Molec. Biol. - 1999. - Vol.69, N.1-6. - P.109-115. 22. Iinaiei I.Ae. Oi?ioaaiiy noaoaaiai aeeii?o?cio ai?noo oa ia?ao a?iaaiieo iiiiai?i?a o uo??a, ye? caciaee aieeao a?ae?iei?oeciio a i?aiaoaeueiee ia??iae iioiaaiaco // Aiaeie?eiieia?y. - 1999. - O.4, ?1. - N. 106-110. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii oaeiae 24 oace aeiiia?aeae ia i?aeia?iaeieo oa ?anioae?eainueeeo c’?caeao, eiioa?aioe?yo oa neiiic?oiao. Aiioaoe?y Iinaiei I.Ae. Iaoai?cie ai?iii-iaae?aoi?iiai ?ii?eioeiao iae?iaiaei-e?eiii? ?aaoeyoe?? ?ai?iaeoeoe?? oa no?an-?aaeoeaiino?. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a a?ieia?/ieo iaoe ca niaoe?aeuei?noth 14.01.14 aiaeie?eiieia?y. ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii aea/aiith ?ie? noa?i?aeieo ai?iii?a ? a?iaaiieo iiiiai?i?a iiceo a oi?ioaaii? ooieoe?iiaeueieo ?iceaae?a ?ai?iaeoeoe?? (aiiaoeyoi?ia iaie?aei?noue) oa no?an-?aaeoeaiino? (neiae?ii i?aiaoaeueiiai no?ano), ye? aeieeathoue aiane?aeie ai?iiiaeueieo oa no?ani?ieo aieea?a ia iicie, ui ?icaeaa?oueny, o ia?eiaoaeueiee ia??iae ?iaeea?aeoaeueiiai ?icaeoeo. A aeena?oaoe?? ?ic?iaeaii iiaee iai?yiie a iae?iaiaeie?eiieia??, yeee a?oioo?oueny ia iae?io?i?/i?e eiioeaioe?? ai?iii-iaae?aoi?iiai ?ii?eioeiao iae?iaiaeie?eiii? nenoaie. Aeiaaaeaii, ui i?ioeane ?ii?eioeiao o iiceo a?aeaoaathoueny ca iaoai?ciii ei?iaeoeoe?? oeyoii aca?iiae?? eaoaoieai?i?a, noa?i?aeieo ai?iii?a oa ?o aeoeaieo iaoaaie?o?a (cie?aia, eaoaoieano?iaai?a), ye? ooai?ththoueny aaciina?aaeiuei a oeaieiao oeaio?aeueii? ia?aiai? nenoaie. Ii?ooaiiy ?ii?eioeiaiaeo iaoai?ci?a aeaoa?i?iothoue o?eaae? ci?ie iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoe?? oa no?an-?aaeoeaiino? a?iioaeaii-a?iio?ca?ii-iaaeie?eiai? nenoaie, ni?yiiaai?noue oa ae?aci?noue eio?eo caeaaeeoue a?ae noao? oaa?ei. ?acoeueoaoe aeine?aeaeaiue iiaeooue neoaeeoe oai?aoe/iei iaa?oiooaaiiyi aeey oe?eani?yiiaaiiai iiooeo cania?a ? iaoiae?a i?io?eaeoeee oa ei?aeoe?? ii?ooaiue iae?iaiaeie?eiii? ?aaoeyoe?? ?ai?iaeoeoeaii? oa aaeaioaoe?eii? nenoai. Eeth/ia? neiaa: noaoaaa aeeoa?aioe?aoe?y iiceo, noaoaaee aeeii?o?ci, i?aiaoaeueiee no?an, noa?i?aei? ai?iiie, a?iaaii? iiiiai?ie, ?ai?iaeoeoe?y, no?an-?aaeoeai?noue, iioiaaiac. Annotation Nosenko N.D. Mechanisms of hormone-mediator imprinting of neuroendocrine regulation of reproduction and stress-reactivity. - Manuscript. Thesis for the degree of Doctor of Biological Sciences by speciality 14.01.14 - Endocrinology. V.P. Komisarenko Institute of Endocrinology and Metabolism, Academy of Medical Science of Ukraine, Kyiv, 1999. The dissertation is devoted to study of the role of steroid hormones and brain biogenic monoamines in forming of functional disturbances of reproductive function (anovulatory sterility) and stress-reactivity (syndrome of prenatal stress), which occur as a result of hormonal and stress effects on the developing brain in perinatal ontogenesis. A new trend in neuroendocrinology is developed in this work, which is based on a neurochemical conception of hormone-mediator imprinting of neuroendocrine system. It has been established that the processes of imprinting in the brain are realized by an interaction between catecholamines, steroid hormones and their active metabolites, in particular, catecholestrogens, by the mechanism of coinduction. Disturbances of imprinting mechanisms determine long-term changes in neuroendocrine regulation of reproduction and stress-reactivity of hypothalamo-pituitary-adrenal system, the direction and degree of which depend on the sex of the animals. The result of these investigations represent a theoretical ground for a purposeful search of means and methods of prevention and correction of neuroendocrine regulation disturbances of reproductive and adaptation systems. Key words: brain sexual differentiation, sexual dimorphism, prenatal stress, steroid hormone, biogenic monoamines, reproduction, stress-reactivity, ontogenesis. Aiiioaoeey Iinaiei I.Ae. Iaoaieciu ai?iii-iaaeeaoi?iiai eii?eioeiaa iae?iyiaei-e?eiiie ?aaoeyoeee ?ai?iaeoeoeee e no?ann-?aaeoeaiinoe. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a aeieiae/aneeo iaoe ii niaoeeaeueiinoe 14.01.14 - yiaeie?eiieiaey. Einoeooo yiaeie?eiieiaee e iaiaia aauanoa ei. A.I. Eiienna?aiei AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia eco/aieth ?iee noa?ieaeiuo ai?iiiia e aeiaaiiuo iiiiaieiia iicaa a oi?ie?iaaiee ooieoeeiiaeueiuo ?anno?ienoa ?ai?iaeoeoeaiie nenoaiu (aiiaoeyoi?iay noa?eeueiinoue) e no?ann-?aaeoeaiinoe (neiae?ii i?aiaoaeueiiai no?anna), eioi?ua aicieeatho aneaaenoaea ai?iiiaeueiuo e no?anni?iuo aicaeaenoaee ia ?acaeaathueeny iica a ia?eiaoaeueiii ia?eiaea eiaeeaeaeoaeueiiai ?acaeoey. Iieacaii, /oi a iniiaa iaoaieciia iaoiaaiiiai aeeyiey i?aiaoaeueiiai no?anna e ai?iiiaeueiiai aeenaaeaina ia nenoaiu ?ai?iaeoeoeee e aaeaioaoeee eaaeao ia?ooaiey ai?iii-iaaeeaoi?iiai eii?eioeiaa iae?iyiaeie?eiiie nenoaiu. ?aiieie i?iyaeaieyie ia?ooaiee ai?iiiaeueiiai eii?eioeiaa aieiaiiai iicaa o iaiiaoaeueii aiae?iaaiece?iaaiiuo naiie e?un yaeyaony iiauoaiea niaea?aeaiey e iai?ioa eaoaoieaieiia a iaaeeiaacaeueiii aeiioaeaiona e oneeaiea iaoaaieecia na?ioiieia a i?aiioe/aneie iaeanoe. Onoaiiaeaii, /oi iaoiaaiiia (aeaoaieiece?othuaa e/eee ianeoeeiece?othuaa) aeaenoaea oanoinoa?iia ia oeaio?u ?aaoeyoeee iieiaie oeeeee/iinoe o naiie e?un iiin?aaeoaony noa?ieaeiuie i?iaeoeoaie a?iiaoecaoeee oanoinoa?iia e aeae?ieneee?iaaiey aai yno?iaaiiuo iaoaaieeoia - eaoaoieyno?iaaiaie. Iaoaieci ?aaeecaoeee yoiai aeeyiey naycai ni noeioeyoeeae iaeiieaiey ii?aae?aiaeeia a aeiioaeaiona a e?eoe/aneii ia?eiaea iieiaie aeeooa?aioeeaoeee iicaa. A iiuoao n aaaaeaieai eiaeaeoi?ia a?iiaoacu N19-noa?ieaeia, iae?ioieneia 6-aeae?ieneaeioaieia, i?aaeoanoaaiieea neioaca eaoaoieaieiia L-AeIOA, a oaeaea 2- e 4-aeae?ieneee?iaaiiuo eciia?ia eaoaoieyno?iaaiia, eioi?ua aaiaeeee iiai?iaeaeaiiui e?unai nenoaiii eee eio?aoea?aa?aeueii, aeieacaii, /oi ii?aae?aiaeei yaeyaony iaeiei ec eiaeoeoi?ia aiae?iaaicaaeneiie iieiaie aeeooa?aioeeaoeee iicaa. Onoaiiaeaii, /oi eaoaoieyno?iaaiu, e i?aaeaea anaai 4-aeae?ieneyno?aaeeie-17, yaeythony oaie noa?ieaeiuie iaoaaieeoaie, eioi?ua niinianoaotho oaaee/aieth eiioeaio?aoeee ii?aae?aiaeeia a aeiioaeaiona iiae aeeyieai iaiiaoaeueiie aiae?iaaiecaoeee a ia?eiae iieiaie aeeooa?aioeeaoeee iicaa. Yoio yooaeo inouanoaeyaony /a?ac oaiaoaiea iaoaaiee/aneie eiaeoeaaoeee eaoaoieaieiia i?e o/anoee eaoaoie-I-iaoeeo?ainoa?acu e ei??aee?oao ni niiniaiinoueth 4-aeae?ieneyno?aaeeiea-17 aini?iecaiaeeoue yooaeou iaiiaoaeueiie aiae?iaaiecaoeee a ioiioaiee ?acaeoey aiiaoeyoi?iie noa?eeueiinoe o ac?ineuo aeeaioiuo. Naeaeaii caeeth/aiea, /oi aiae?iaaicaaeneiay aeeooa?aioeeaoeey aeiioaeaie/aneiai eiio?iey nae?aoeee aiiaaeio?iiiuo ai?iiiia yaeyaony ?acoeueoaoii niaianoiiai aeeyiey eaoaoieaieiia e yno?iaaiiuo iaoaaieeoia, eioi?ua aunooiatho a ?iee eiaeoeoi?ia nic?aaaiey iae?iyiaeie?eiiie nenoaiu ?aaoeyoeee ?ai?iaeoeoeee. Iieacaii, /oi no?ann iaoa?eineiai i?aaiecia a oa/aiea iineaaeiae iaaeaee aa?aiaiiinoe i?aiyonoaoao oi?ie?iaaieth iieiaiai aeeii?oecia niaea?aeaiey e iai?ioa eaoaoieaieiia a i?aiioe/aneie iaeanoe e iaaeeiaacaeueiii aeiioaeaiona o iioiieia a ?aiiai iinoiaoaeueiii ia?eiaea aeecie. Yoi inouanoaeyaony aneaaenoaea iiauoaiey niaea?aeaiey e, niioaaonoaaiii, nieaeaiey iai?ioa ii?aae?aiaeeia a i?aiioe/aneie iaeanoe naioeia aei o?iaiy, i?enouaai ii?iaeueiui naieai, e iiauoaiey niaea?aeaiey e iai?ioa aeioaieia a iaaeeiaacaeueiii aeiioaeaiona naiie aei o?iaiy, oa?aeoa?iiai aeey ii?iaeueiuo naioeia. Iiae aeeyieai i?aiaoaeueiiai no?anna oneeeaaaony iaoaaieeci na?ioiieia a i?aiioe/aneie iaeanoe naiie e iaaeeiaacaeueiii aeiioaeaiona naioeia. Ii?oieiae/aneei i?iyaeaieai iaoiaaiiiai aeeyiey i?aiaoaeueiiai no?anna ia iieiaoth aeeooa?aioeeaoeeth iicaa yaeyaony en/aciiaaiea iieiauo ?acee/ee a iauaia yaea? iae?ioeeoia noi?aoeaciaoe/aneeo yaea? ia?aaeiaai aeiioaeaiona. Aaaaeaiea aeae?iei?oeciia aa?aiaiiui naieai aini?iecaiaeeo yooaeou i?aiaoaeueiiai no?anna a ioiioaiee ?aiieo iinoiaoaeueiuo eciaiaiee niaea?aeaiey e iai?ioa ii?aae?aiaeeia e na?ioiieia a i?aiioe/aneie iaeanoe, /oi naeaeaoaeuenoaoao ia iiin?aaeiaaiiuo aetheiei?oeeieaeaie iaoa?eineiai i?aaiecia iaoaieciao ?acaeoey iiiiaieia?ae/aneeo nenoai aieiaiiai iicaa a ?aiiai iioiaaiaca. Auyaeaiu iieiaua e aic?anoiua iniaaiiinoe yooaeoia i?aiaoaeueiiai no?anna ia no?ann-?aaeoeaiinoue aeiioaeaii-aeiioeca?ii-iaaeii/a/ieeiaie nenoaiu o e?un. Iiae aeeyieai i?aiaoaeueiiai no?anna ai?iiiaeueiay ?aaeoeey ei?u iaaeii/a/iuo aeaeac ia ino?ue eiiiaeeecaoeeiiiue no?ann o ac?ineuo naiie oia?aiii oneeeaaaony, a o naioeia nouanoaaiii nieaeaaony. Iniiaiui iaoiaaiaoe/aneei caaiii ineaaeaiiie no?ann-?aaeoeaiinoe aeiioeca?ii-iaaeii/a/ieeiaie nenoaiu o ac?ineuo i?aiaoaeueii no?anne?iaaiiuo naioeia e?un yaeyaony cia/eoaeueiia oiaiueoaiea inaiaiaeaeaiey ii?aae?aiaeeia a aeiioaeaiona a ioaao ia ino?ue no?ann. Iieacaii, /oi a ia?eiae noa?aiey o i?aiaoaeueii no?anne?iaaiiuo naioeia e?un nio?aiyaony niiniaiinoue eaoaoieaieiia aeiioaeaiona ?aaae?iaaoue ia no?anni?iua noeioeu ia oiia cia/eoaeueiie aeoeaaoeee ooieoeee ei?u iaaeii/a/iuo aeaeac. Iiae aeeyieai i?aiaoaeueiiai no?anna o noa?uo naiie nieaeathony aaeaioeaiua aiciiaeiinoe eaoaoieaieiiaie nenoaiu aeiioaeaiona, iaeiaei nio?aiyaony aae?aiiei?oeeaeueiay ?aaeoeey ia ino?ue no?ann. ?aaioa iainiiauaaao iae?ioeie/aneoth eiioeaioeeth ai?iii-iaaeeaoi?iiai eii?eioeiaa iae?iyiaeie?eiiie nenoaiu, niaeanii eioi?ie ioaeaeaiiua yooaeou ia?eiaoaeueiuo ai?iiiaeueiuo e no?anni?iuo aicaeaenoaee ia iae?iyiaeie?eiioth nenoaio ?aaoeyoeee ?ai?iaeoeoeee e no?ann-?aaeoeaiinoe aeaoa?ieie?iaaiu ?aiieie iinoiaoaeueiuie eciaiaieyie niaea?aeaiey e iaoaaieecia aeiaaiiuo iiiiaieiia e noa?ieaeiuo ai?iiiia. Eeth/aaua neiaa: iieiaay aeeooa?aioeeaoeey iicaa, iieiaie aeeii?oeci, i?aiaoaeueiue no?ann, noa?ieaeiua ai?iiiu, aeiaaiiua iiiiaieiu, ?ai?iaeoeoeey, no?ann-?aaeoeaiinoue, iioiaaiac. Ii?aae?aiae?i wmetafile8? ??H?? ????????? ???????yyy???????????? „i??? ????'yy??? ??????? ????yyy???? ???????uoy??????1/4???I???"Arial Cyr?I????-?????uoy?????? 2-II-A1 4-II-A2-17 2-II-A2 4-II-A2-17 (30 oa) (1 aiae) (4 aiae) (24 aiae) Eiio?ieue I?aiaoaeueiee no?an wmetafile8? ??c??????????? ???????yyy???????????? „i??? ????'yy??? ??????? ????yyy???? ???????uoy??????1/4???I???"Arial Cyr?I????-?????uoy?????? wmetafile8? ??oe??????????? ???????yyy???????????? _I??? ????'yy??? ??????? ????yyy???? ???????uoy??????1/4???I???"Arial Cyr?I????-?????uoy?????? 5 11 21 A?e oaa?ei (i?n) Naiee Naioe? Naioe? Naiee wmetafile8? ???? ????????? ???????yyy???????????? ‰+??? ????'yy??? ??????? ????yyy???? ???????uoy??????1/4???I???"Arial Cyr?I????-?????uoy?????? Eiio?ieue I?aiaoaeueiee Eiio?ieue I?aiaoaeueiee no?an no?an Aacaeueiee ??aaiue 1aiae ?iiia?e?caoe?y Oaaeeoey 1 Ai?no oa ia?a eaoaoieai?i?a ? na?ioii?io a i?aiioe/i?e ae?eyioe? oa iaae?iaacaeueiiio a?iioaeaion? uo??a 10-aeaiiiai a?eo, ye? caciaee aieeao a?ae?iei?oeciio a i?aiaoaeueiee ia??iae aeeooy (Im, n=6-11) IieacieeEiio?ieueA?ae?iei?oeciinaieenaioe?naieenaioe?I?aiioe/ia ae?eyieaIA, iiieue/a oeaieie4,22 0,48 2,74 0,38 (a) 2,64 0,37 (a) 2,16 0,31AeA, iiieue/a oeaieie3,45 0,68 4,12 0,36 2,54 0,23 3,24 0,22Oaeaee?noue ia?ao IA, iiieue/a/aiae.0,99 0,21 1,89 0,45 0,45 0,20 0,33 0,09 (b)Oaeaee?noue ia?ao AeA, iiieue/a/aiae0,33 0,11 0,73 0,19 0,69 0,12 (a) 1,13 0,27NO, ia/ia oeaieie0,43 0,03 0,35 0,02 0,43 0,04 0,52 0,03 (b)5-A?IE, ia/ia oeaieie0,73 0,14 0,87 0,08 1,71 0,09 (a) 1,42 0,07 (a, b, c)5-A?IE/NO1,80 0,36 2,49 0.23 4,22 0,58 (a) 2,76 0,15 (a, c)Iaae?iaacaeueiee a?iioaeaionIA, iiieue/a oeaieie3,76 0,33 3,35 0,23 4,32 0,24 3,86 0,19AeA, iiieue/a oeaieie3,59 0,24 3,21 0,22 2,63 0,67 3,51 0,19Oaeaee?noue ia?ao IA, iiieue/a/ aiae.0,53 0,09 0,78 0,13 0,72 0,12 0,62 0,17Oaeaee?noue ia?ao AeA, iiieue/a/ aiae0,42 0,11 0,69 0,12 0,61 0,19 0,62 0,29NO, ia/ia oeaieie0,44 0,05 0,64 0,15 0,36 0,02 0,33 0,045-A?IE, ia/ia oeaieie0,74 0,08 1,03 0,14 1,51 0,14 (a, b) 1,11 0,06 (a, c)5-A?IE/NO1,85 0,31 2,23 0,57 4,19 0,39 (a, b) 3,57 0,59 (a)I?ei?oea: ??cieoey aeinoia??ia P<0,05 (iaia?aiao?e/iee U-oano) ii a?aeiioaiith: (a) - aei eiio?ieueieo naiie, (b) - aei eiio?ieueieo naioe?a, (c) - aei naiie, ye? caciaee aieeao a?ae?iei?oeciio a i?aiaoaeueiee ia??iae

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