I?I?NOA?NOAI INA?OE OE?A?IE

OA?E?ANUeEEE AeA?AEAAIEE OI?AA?NEOAO

Aa?aii?e Oaoyia Aieiaeeie??aia

OAeE 577.151.04:57.044:546(492+732)

IAOAIICIE AeI? OEI?EAeO ?OOOI OA

OEI?EAeO EIAAEUeOO IA AEOEAIINOUe

(-AIIIIEAAOEIIAONEIOACE A IA*IIOeI UO?IA

03.00.04– A?io?i?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien. ?iaioo aeeiiaii ia eaoaae?? a?io?i??
Oa?e?anueeiai aea?aeaaiiai oi?aa?neoaoo I?i?noa?noaa ina?oe Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani?

Eae?iai Iaaei Aaenaio?eiae/,

caa?aeoaa/ eaoaae?ith a?io?i??

Oa?e?anueeiai aea?aeaaiiai oi?aa?neoaoo

I?i?noa?noaa ina?oe Oe?a?ie

Io?oe?ei? iiiiaioe: aeieoi? a?ieia?/ieo iaoe, i?ioani?

*a/ioe?i Ieaen?e Aaneeueiae/,

caa?aeoaa/ eaoaae?ith o?i?? oa a?io?i??

Oa?e?anueeiai ciiaaoa?eia?iiai ?inoeoooo

I?i?noa?noaa ina?oe Oe?a?ie

aeieoi? a?ieia?/ieo iaoe,

noa?oee iaoeiaee ni?a?ia?oiee,

Ia?nueeee ?aaai Ao?i?iiae/, i?ioani? ca eaoaae?ith o?c?ieia?? ethaeeie
oa oaa?ei Oa?e?anueeiai aea?aeaaiiai oi?aa?neoaoo I?i?noa?noaa ina?oe
Oe?a?ie

I?ia?aeia onoaiiaa ?inoeooo a?io?i?? ?i. I.A.Iaeeaae?ia IAI Oe?a?ie
(a?aeae?e a?io?i?? eioa?iaio?a), i.Ee?a.

Caoeno a?aeaoaeaoueny » 07 » ea?oiy 1999 ?. i 1515 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 64.051.17 i?e Oa?e?anueeiio
aea?aeaaiiio oi?aa?neoao? I?i?noa?noaa ina?oe Oe?a?ie ca aae?anith:
310077, Oa?e?a, ie.Naiaiaee, 4, aoae.III-15.

C aeena?oaoe??th iiaeia iciaeiieoenue o Oeaio?aeuei?e iaoeia?e
a?ae?ioaoe? Oa?e?anueeiai aea?aeaaiiai oi?aa?neoaoo I?i?noa?noaa
ina?oe Oe?a?ie ca aae?anith: 310077, Oa?e?a-77, ie.Naiaiaee, 4.

Aaoi?aoa?ao ?ic?neaiee 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee eaiaeeaeao a?ieia?/ieo
iaoe, noa?oee iaoeiaee ni?a?ia?oiee

Iaaeaeei A.?.

Caaaeueia oa?aeoa?enoeea ?iaiOE

Aeooaeuei?noue oaie. Oe?iea aeei?enoaiiy aaaeeeo iaoae?a a ae?iaie/eo
oe?eyo, ca?eueoaiiy ia’?io ?o aeiaoaaiiy oa ia?a?iaee ni?e/eieee
inoaii?i /anii cia/ia iaeiie/aiiy aaaeeeo iaoae?a oa ?o niieoe a
iaaeieeoiueiio na?aaeiaeu? [O?aooaiaa?a E.I., Eieanieeia A.N., Eoeiaaiei
A.I., 1994]. Iaaeeeoeiaa iaaeoiaeaeaiiy iaoae?a aei i?aai?cio ethaeeie
oa oaa?ei aeeeeea? ??ciiiai?oi? ooieoe?iiaeuei? oa iaoaaie?/i?
ii?ooaiiy [Iineaeaa TH.E., 1985; A?oia TH.A., Ieaoaiaaa O.A., 1989], o
oiio /ene? iia’ycai? c a?ineioacii aaio oa aaiii?ioa?i?a [Marks G.,
1985]. ?icaeoie oiene/ieo ii?o???e oa cieaeaiiy ai?noo ee?oeiieo
aaiii?ioa?i?a i?ae aieeaii nieae aaaeeeo iaoae?a a cia/i?e i??? ?
iane?aeeii ii?ooaiiy ?aaoeyoe?? eeth/iaiai oa?iaioo a?ineioaco aaio
(-ai?iieaaoe?iaoneioace (EO 2.3.1.37) [Rimington C., 1989]. Anoaiiaeaii,
ui nie? eiaaeueoo, ieaoeie, i?eaeth aai cae?ca aeeeeeathoue aeaiooaci?
ci?ie aeoeaiino? (-ai?iieaaoe?iaoneioace ((-AEE-neioace) a ia/?ioe?
nnaaoe?a: cieaeaiiy a ia?o? aiaeeie ? iiaeaeueoa i?aeaeuaiiy [Maines
M.D., 1984; Eaeeiai I.A., Aaeiaaoeeay E.A., 1986]. Iaeiae iaoai?cie ye
aaeueioaaiiy, oae ? ?iaeoeoe?? ?iiaie iaoae?a eeth/iaiai oa?iaioo
a?ineioaco aaio caeeoathoueny ia i?iyniaieie. Ia aea/aii oaeiae aieea
ia (-AEE-neioacio aeoeai?noue iai?aai?/ieo niieoe ?ooo?, ai?no yeeo a
iaaeieeoiueiio na?aaeiaeu? cia/ii ca?eueoeeinue [O?aooaiaa?a E.I.,
Ei?ooi I.I., 1990].

Ii?yae c i?yiith ?ia?aoth/ith ae??th ia neioac aai aeoeai?noue
(-AEE-neioace, nie? aaaeeeo iaoae?a iiaeooue aeeeeeaoe i?aeaeuaiiy a
ee?oeiao ia/?iee eiioeaio?aoe?? a?eueiiai aaio [Eaeeiai I.A. e ae?.,
1996; Ieeeo/aiei E.A. e ae?., 1998], ui ? iniiaiei ?aaoeyoi?ii
aeoeaiino? (-AEE-neioace [May B.K. et al., 1990; Ades I.Z., 1990;
Lathrop J.T., Timko M.P., 1993], aea aeaea?aea iaeiie/aiiy aaio ia
anoaiiaeai?. Aeooaeueiith i?iaeaiith a oeueiio ieai? iinoa? iiooe
iiaeeeaeo oeyo?a caiia?aaiiy aaiie?co i?ae aieeaii aaaeeeo iaoae?a c
iaoith aeeeth/eoe iaaei??ia iaaeoiaeaeaiiy aaio a ia/?ieo c e?ia’yiiai
?oneo. Aeiaeaoeiaei iaoai?ciii ae?? ?ii?a Co2+, Zn2+, Sn2+ ia
(-AEE-neioaco iiaea c’yaeoenue oi?ioaaiiy iaoaeiii?o??eiiaeo
eiiieaen?a, oei /anii ye ?iie Hg2+, Pb2+, Ni2+, Pt2+ oa ?io? ia
caeaoi? cai?uoaaoe Fe2+ a aaiii?ioa?iao [Maines M.D., 1984]. Aeacai?
?ica?aeiino? aeanoeainoae ?ii?a eiaaeueoo oa ?ooo?, ii?yae c ?o oe?ieei
aeei?enoaiiyi a i?aeoe/i?e ae?yeueiino? ethaeeie oa cia/iei
?iciianthaeaeaiiyi a ciai?oiueiio na?aaeiaeu? [O?aooaiaa?a E.I.,
Eieanieeia A.N., Eoeiaaiei A.I., 1994], iaoiiaeee aea?? oeeo iaoae?a
aeey aeine?aeaeaiiy.

A?aoiaoth/e aeuaaeeeaaeaia, anoaiiaeaiiy iaoai?ci?a ae?? oei?eaeo ?ooo?
oa oei?eaeo eiaaeueoo ia aeoeai?noue eeth/iaiai oa?iaioo a?ineioaco
aaio, (-AEE-neioace, a ia/?ioe? nnaaoe?a c’yaey?oueny aeooaeueiei oa
ia?niaeoeaiei a ieai? iiaeaeueoi? ?ic?iaee ?aeiiaiaeaoe?e uiaei
e?eoaaiiy aino?eo io?o?iue nieyie aaaeeeo iaoae?a oa oiene/ieo ii?o???e.

Aca?iica’ycie aeaii? ?iaioe c iaoeiaeie i?ia?aiaie. Aeena?oaoe?eia
aeine?aeaeaiiy aoei /anoeiith aea?aeathaeaeaoii? oaie IAe? a?ieia??
Oa?e?anueeiai aea?aeoi?aa?neoaoo «Eeioeiii oa iieaeoey?ii iaoaiicie
aaeaioaoei? iaoaaieicio i?e ieeniiio no?ani» (? Ae? 0197U008188).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei anoaiiaeaiiy
iniiaieo iaoai?ci?a ae?? ?ii?a Hg2+ ? Ni2+ ia aeoeai?noue (-AEE-neioace
a ia/?ioe? ? ?ie? aaiie?co oa ci?i ??aiy a?aeiiaeaiiai aeooao?iio (GSH)
a ?aae?caoe?? oeeo iaoai?ci?a. O ca’yceo c iaoith aeine?aeaeaiiy, a
oaeiae a?aoiaoth/e, ui ??aaiue a?aeiiaeaiiai aeooao?iio a cia/i?e i???
aecia/a?oueny aeoeai?noth aeooao?ii?aaeoeoace ? aaia?aoe??th IAAeOI
[Pinto R.E., Barley W., 1969], aoee iinoaaeai? oae? caaea/?:

Aea/eoe aieea HgCl2 oa CoCl2 ia aeoeai?noue (-AEE-neioace,
aeooao?ii?aaeoeoace, aetheici-6-oinoaoaeaaeae?iaaiace oa ai?no
a?aeiiaeaiiai aeooao?iio a ia/?ioe?, a oaeiae ia ai?no i?iaeoeo?a
aaiie?co ? aai-ca’ycoaaeueiiai a?eeo aaiiiaeneio a ne?iaaooe? e?ia?
uo??a.

Aea/eoe aieea HgCl2, aai?io oa ne?iaaoee e?ia? ?ioaeoieo ? aeine?aeieo
oaa?ei ia aeoeai?noue (-AEE-neioace ia/?ioe? a aeine?aeao in vitro.

A?aoiaoth/e aeai? uiaei aioeaaiie?oe/ii? ae?? (-aae?aiiaeieaoi?o
i?ii?aiieieo [Niieineee A.I. e ae?., 1988] oa aioeieneaeaioii? ae??
a?aeiiaeaiiai aeooao?iio [Meister A., Anderson M.E., 1983], aea/eoe
aieea noi?niiai aaaaeaiiy i?ii?aiieieo ? HgCl2 aai CoCl2, a oaeiae
noi?niiai aaaaeaiiy CoCl2 ? GSH, ia aeuaiaaaaeai? a?io?i?/i? iieacieee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa anoaiiaeaii, ui oei?eae
eiaaeueoo aeeeeea? iaeiie/aiiy a ne?iaaooe? e?ia? iiaeeo?eiaaieo
eiaaeueoii aaiii?ioa?i?a oa a?eueo ae?aaeaia ? o?eaaea, o ii??aiyii? c
oei?eaeii ?ooo?, aaeueioaaiiy aeoeaiino? (-AEE-neioace a ia/?ioe?.

Aia?oa anoaiiaeaii, ui cieaeaiiy aeoeaiino? (-AEE-neioace a ia/?ioe? ?
iaeiie/aiiy i?iaeoeo?a aaiie?co a ne?iaaooe? e?ia? a ia?o? aiaeeie ae??
HgCl2 oa CoCl2 caiia?aa?oueny i?e iiia?aaeiueiio aaaaeaii?,
a?aeiia?aeii, (-aae?aiiaeieaoi?o i?ii?aiieieo oa a?aeiiaeaiiai
aeooao?iio.

Iieacaii, ui ?iaeoeoth/a ae?y aea/aieo nieae iaoae?a ia (-AEE-neioacio
aeoeai?noue iiaea aooe iineaaeaia iiia?aaei?i aaaaeaiiyi i?ii?aiieieo
aai, ye anoaiiaeaii aeey oei?eaeo eiaaeueoo, aaaaeaiiyi a?aeiiaeaiiai
aeooao?iio.

Anoaiiaeaii, ui ci?ie ai?noo a?aeiiaeaiiai aeooao?iio a ia/?ioe? i?e
ae?? HgCl2 oa CoCl2 a iaai?e i??? caeaaeaoue a?ae iaeiie/aiiy i?iaeoeo?a
aaiie?co a ne?iaaooe? e?ia? ? caiia?aathoueny a oiiaao a?aenooiino?
aaiie?co.

Oai?aoe/ia oa i?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Caeiaoo? a
oe?e ?iaio? aeai? na?ae/aoue i?i caeaaei?noue aeeiai?ee aeoeaiino?
eeth/iaiai oa?iaioo a?ineioaco aaio a?ae iaeiie/aiiy i?iaeoeo?a
aaiie?co ? caeaoiino? ?ii?a iaoaeo oi?ioaaoe iaoaeiii?o??eiiaee
eiiieaen, ui cia/ii ?icoe?th? oyae uiaei ?aaoeyoe?? a?ineioaco aaio a
ia/?ioe? nnaaoe?a.

I?aeoe/ia cia/aiiy ia? anoaiiaeaiiy aaaeeeai? ?ie? aaiie?co a
iaoai?ciao ae?? ?ii?a aaaeeeo iaoae?a ia a?ineioac aaio a ia/?ioe?, a
oaeiae caeaoiino? (-aae?aiiaeieaoi?o i?ii?aiieieo oa a?aeiiaeaiiai
aeooao?iio caiia?aaoe aaiie?co a ia?o? aiaeeie ae??, a?aeiia?aeii, HgCl2
oa CoCl2. Caa??aaiiy aeoeaiino? (-AEE-neioace a ia/?ioe? ia
eiio?ieueiiio ??ai? a ia?o? aiaeeie ? ciaioaiiy aai caiia?aaiiy
iiaeaeueoi? ?iaeoeoe?? oa?iaioo i?ae aieeaii oeeo iaoae?a a oiiaao
a?aenooiino? aaiie?co iiaea aooe aeei?enoaii i?e ?ic?iaoe?
oa?aiaaoe/ieo caoiae?a uiaei e?eoaaiiy io?o?iue nieyie aaaeeeo iaoae?a
oa oiene/ieo ii?oe??e.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia aeine?aeaeaiiy aeeiiaii
i?ae iaoeiaei ea??aieoeoaii aeieo. a?ie. iaoe I.A.Eae?iaia, a
ni?a?ia?oieoeoa? c eaiae. a?ie. iaoe ?.A.I?e?o/aiei, c yeeie aaoi? ia?
ni?euei? ioae?eaoe??. An? ?acoeueoaoe, ui i?eaaaeai? a ?oeiieno,
iaea?aeai? aaoi?ii naiino?eii. Aeena?oaioii iniaenoi i?iaaaeaii
aenia?eiaioe ? aecia/aiiy aea?aieo aeey aeine?aeaeaiiy a?io?i?/ieo
iieaciee?a, i?iaiae?ciaaia e?oa?aoo?a ca oaiith aeine?aeaeaiiy,
iaaiai?aii iaea?aeai? ?acoeueoaoe.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Ca iaoa??aeaie aeena?oaoe??
c?iaeai? aeiiia?ae? ia i?aeia?iaeiiio neiiic?oi? «Aeieiae/aneea
iaoaieciu noa?aiey», Oa?e?a, 1996 ? ., ia VII a?io?i?/iiio c’?cae?,
Ee?a, 1997 ?., ia i?aeia?iaei?e eiioa?aioe?? «Ooiaeaiaioaeueiua e
i?eeeaaeiua aniaeou nia?aiaiiie aeioeiee», N.-Iaoa?ao?a, 1998 ?., ia
iaoeia?e eiioa?aioe?? iieiaeeo a/aieo-a?ieia?a OAeO, Oa?e?a 1996 ?.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 4 noaoo? oa 5 oac
aeiiia?aeae.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, iaoiaee/ii? /anoeie, o?ueio ?icae?e?a ?acoeueoao?a
aeine?aeaeaiue oa ?o iaaiai?aiiy, aeniiae?a ? ia?ae?eo e?oa?aoo?ieo
iineeaiue (260 aeaea?ae). ?iaioa aeeeaaeaia ia 136 noi?. ?acoeueoaoe
aeine?aeaeaiue ?ethno?iaaii 19 ?enoieaie oa 17 oaaeeoeyie.

INIIAIEE CI?NO ?IAIOE

O ia?oiio ?icae?eo ?iaioe iiaeaii iaeyae e?oa?aoo?e ca oaiith
aeena?oaoe??. Iniaeeaa oaaaa i?eae?eaia iniiaiei iaoai?ciai ?aaoeyoe??
(-ai?iieaaoe?iaoneioace a ia/?ioe? nnaaoe?a, a oiio /ene? ?ie? aaio,
aai-ca’ycoaaeueieo a?ee?a oa ai?iiiaeueieo oaeoi??a a ?aaoeyoe??
oa?iaioo, a oaeiae aieeao nieae aaaeeeo iaoae?a oa ci?i ??aith
a?aeiiaeaiiai aeooao?iio a ia/?ioe?. ?icaeyiooe a?ieia?/i? ooieoe?? GSH,
oa oaeoi?e, ui aieeaathoue ia eiai ai?no a ia/?ioe? nnaaoe?a.

O ae?oaiio ?icae?eo iienaii iaoa??aee oa iniiai? iaoiaee aeine?aeaeaiiy.

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

A ?iaio? aeei?enoai? uo?e e?i?? A?noa? 3-o i?ny/iiai a?eo iaio noaoae.
Naiee ciaoiaeeeenue a oac? proestrus [Ee?oaiaeao ss.Ae., 1973].
CoCl2(6H2O oa HgCl2 aoei aaaaeaii a noaeaoaeuei?e aeic?,
a?aeiia?aeii, 3 ia [Maines M.D., 1977; Eaeeiai I.A., Aaeiaaoeeay E.A,
1986] oa 0,7 ia [Maines M.D., 1977] ia 100 a iane o?ea oaa?eie.
I?ii?aiieie (0,025% ?ic/ei) aoei aaaaeaii a aeic? 0,15 ia ia 100 a
iane o?ea [Bassukevitz Y. et al., 1989], a?aeiiaeaiee aeooao?ii (10%
?ic/ei) – a aeic? 50 ia ia 100 a iane o?ea [Eiiaae A.Ae. e ae?.,
1988]. An? niieoee aaaaeaii aioo??oiuei/a?aaeiii. I?e noi?niiio
aaaaeaii? i?ii?aiieie aoei aaaaeaii ca 30 oa aei aaaaeaiiy oei?eaeo
eiaaeueoo aai ?ooo?, a?aeiiaeaiee aeooao?ii – ca 15 oa aei aaaaeaiiy
CoCl2. Oaa?ei a?aee a aeine?ae i?ney aaaaeaiiy HgCl2 aai CoCl2 – /a?ac
30 oa, 2 aiae aai 24 aiae; i?ney aaaaeaiiy o?eueee i?ii?aiieieo – /a?ac
1 aiae, 2,5 aiae aai 24 aiae (eiio?ieue ia aeieaoi?); i?ney aaaaeaiiy
o?eueee a?aeiiaeaiiai aeooao?iio – /a?ac 15 oa, 45 oa oa 2 aiae
(eiio?ieue ia GSH). Ia’?eoii aeine?aeaeaiiy aoee ia/?iea oa e?ia
oaa?ei. A aeine?aeao in vitro aeei?enoaii ia/?ieo ?ioaeoieo
uo??a-naioe?a.

Ia/?ieo ia?oocoaaee oieiaeiei o?c?ieia?/iei ?ic/eiii in situ.
Iinoi?oioiiae??aeueio o?aeoe?th io?eioaaee aeeoa?aioe?aeueiei
oeaio?eooaoaaiiyi a 0,1 I E-Na-oinoaoiii aooa??, pH 7,5 [Auaiei I.Ae.,
1982].

Aecia/aiiy (-AEE-neioacii? aeoeaiino? i?iaaaeaii a aiiiaaiao? ia/?iee
ca iaoiaeii [Marver H.S. et al., 1966]. (-AEE, ui ooai?thaaeanue, aoei
ia?aaaaeaii aei oi?ie i??ieo eei’yo?iiyi a i?enooiino? aoeaoeeaoeaoiio
[Granick S., 1966]. I??ieueio oi?io (-AEE a?aeae?eyee a?ae
ai?iiaoeaoiio [Sassa S. et al., 1975] oa ?? ai?no aecia/aee i?ney
caaa?aethaaiiy ?aaeoeaii Y?e?oa. Ieoiio aeoeai?noue oa?iaioo ae?aaeaee
a iiieue (-AEE/ ia a?eeo ca 1 aiae.

Ai?no GSH aecia/aee a aiiiaaiao? ia/?iee niaeo?ioioiiao?e/ii ii
iiaeeiaiith eiiieaeno c aeeienaiii i?e 305 ii [Iooeeeia O.A., 1982] oa
ae?aaeaee a ieiieue/a ne?i? oeaieie. Aeoeai?noue aeooao?ii?aaeoeoacu
[*a?iia I.I., 1979] oa aetheici-6-oinoaoaeaaeae?iaaiace [Bottomley R.H.
et al., 1963] aecia/aee a iinoi?oioiiae??aeuei?e o?aeoe??
niaeo?ioioiiao?e/ii ii ci?i? iiaeeiaiiy IAAeOI (340 ii) i?e 37oC a
i?enooiino? a?aeiia?aeieo noano?ao?a. Aeoeai?noue oa?iaio?a ae?aaeaee a
iiieue IAAeOI/ia a?eeo ca 1 oa.

Niaeo? iiaeeiaiiy ne?iaaoee e?ia? ?a?no?oaaee ia aeaioi?iiaiaaiio
niaeo?ioioiiao?? Specord UV-VIZ i?e 37oC a 0,1 I Na-oinoaoiiio aooa??,
?I 7,1 [Hrkal Z., Muller-Eberhard U., 1971]. Ia i?aenoaa? ci?i
iioe/ii? aonoeie ne?iaaoee e?ia? a Soret-cii? (ciia iiaeeiaiiy
aaiii?ioa?i?a: 380-450 ii) oa i?e 280 ii ?iaeee aeniiaie i?i ai?no,
a?aeiia?aeii, aaio oa aaiii?ioa?i?a [Smith A., 1993; Yonetani T. et al.,
1974] (i?iaeoeoe aaiie?co), oa aaiiiaeneio [Takahashi N. et al., 1985].
Iioe/io aonoeio ?ic?aoiaoaaee ii ??cieoe? iaeneioio oa i?i?ioio
iiaeeiaiiy a a?aeiia?aei?e cii? [Perkampus H.-H., 1992] oa ae?aaeaee a
( A/ia a?eeo.

Ai?no a?eeo aecia/aee ca iaoiaeii Eio?? a iiaeeo?eaoe?? I?eea?a
[Miller G.L., 1959]. Noaoenoe/io ia?iaeo i?iaaaeaii ca iaoiaeii
Nouethaeaioa-O?oa?a.

O o?aoueiio, /aoaa?oiio oa i’yoiio ?icae?eao aeena?oaoe?? iaaaaeaii
iniiai? ?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

Aieea oei?eaeo ?ooo? oa oei?eaeo eiaaeueoo ia aeoeai?noue
(-ai?iieaaoe?iaoneioace oa ai?no a?aeiiaeaiiai aeooao?iio a ia/?ioe?
uo??a. Oei?eae ?ooo? oa oei?eae eiaaeueoo aeeeeeathoue aeaiooacio ci?io
(-AEE-neioacii? aeoeaiino? a ia/?ioe? uo??a iaio noaoae a ia?oo aeiao
i?ney aaaaeaiiy: cieaeaiiy a ia?o? aiaeeie c ianooiiei i?aeaeuaiiyi ia
24 aiaeeio (oaae.1,2).

Oaaeeoey 1

Aeoeai?noue (-AEE-neioace, aeooao?ii?aaeoeoace,
aetheici-6-oinoaoaeaaeae?iaaiace (Ae-6-OAeA) oa ai?no GSH a ia/?ioe? ?
iioe/ia aonoeia ne?iaaoee e?ia? uo??a-naioe?a a ??ci? no?iee i?ney
aaaaeaiiy HgCl2 aai CoCl2 (M±m, n=6-8)

*an i?ney ae??

Ae?y Eiio?ieue 30 oa 2 aiae 24 aiae

Aeoeai?noue (-AEE-neioace, iiieue AEE/ia a?eeo ca 1 aiae

HgCl2 0,098±0,003 0,067±0,006(p3) 0,096±0,007 0,168±0,009(p3)

CoCl2 0,085±0,007 0,025±0,004(p3) 0,036±0,004(p3) 0,141±0,010(p2)

Iioe/ia aonoeia ne?iaaoee e?ia? a Soret-cii?, (A/ia a?eeo

HgCl2 0,045±0,002 0,064±0,004(p2) – –

CoCl2 0,045±0,002 0,052±0,003(t) 0,060±0,002(p2) 0,036±0,002(p1)

Iioe/ia aonoeia ne?iaaoee e?ia? i?e 280 ii, (A/ia a?eeo

HgCl2 0,69±0,06 0,52±0,03(p1) – –

CoCl2 0,71±0,05 0,60±0,06 0,55±0,02(p1) 0,69±0,03

Ai?no a?aeiiaeaiiai aeooao?iio, ieiieue/a oeaieie

HgCl2 4,81±0,24 4,19±0,2(t) 3,47±0,14(p3) 5,34±0,23

CoCl2 4,41±0,22 3,64±0,3(t) 3,88±0,3 5,08±0,26(t)

Aeoeai?noue aeooao?ii?aaeoeoace, iiieue IAAeOI/ia a?eeo ca 1 oa

HgCl2 73,9±5,8 70,3±4,1 55,2±4,9(p1) 75,9±5,2

CoCl2 69,9±5,4 82,9±5,1 53,7±7,1(p1) 66,8±4,2

Aeoeai?noue Ae-6-OAeA, iiieue IAAeOI/ia a?eeo ca 1 oa

HgCl2 27,3±2,5 30,2±2,4 20,8±1,2(p1) 32,3±2,6

CoCl2 31,3±2,4 37,7±3,0 42,5±3,2(p1) 53,2±5,1(p2)

I?ei?oee: p1 – p<0,05 a?aeiinii aei eiio?ieth; p2 – p<0,01 a?aeiinii aei eiio?ieth; p3 – p<0,001 a?aeiinii aei eiio?ieth; t – 0,05

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