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Лікування остеомієлітів нижньої щелепи із застосуванням комбінованого іонофорезу антибіотиків з димексидом та гепарину (експериментально-клінічне досл

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EUeA?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO ?i.AeAIEEA AAEEOeUeEIAI

Iie?ee Ieaa ss?ineaaiae/

OAeE 616.716.4 – 018.44 – 002 – 085.84

E?EOAAIIss INOAII??E?O?A IEAEIUeI? UAEAIE ?C CANOINOAAIIssI
EIIA?IIAAIIAI ?IIIOI?ACO AIOEA?IOEE?A C AeEIAENEAeII

OA AAIA?EIO

(ANIA?EIAIOAEUeII – EE?I?*IA AeINE?AeAEAIIss)

14.01.22 – Noiiaoieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Euea?a -1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
Aeaieea Aaeeoeueeiai

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, i?ioani?

Aioue ?aai Ie?ineaaiae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? noiiaoieia?? Euea?anueeiai aea?aeaaiiai
iaaee/iiai

oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? ?oc?i Aaiaae?e
I?iooniae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? noiiaoieia?? Oa?e?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo

aeieoi? iaaee/ieo iaoe, aeioeaio Aiae TH??e Aieiaeeie?iae/,

caa?aeoaa/ eaoaae?e o??o?a?/ii? oa i?oiiaaee/ii? noiiaoieia??
Euea?anueeiai aea?aeaaiiai

iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai

I?ia?aeia onoaiiaa: Oe?a?inueea iaaee/ia noiiaoieia?/ia aeaaeai?y IIC
Oe?a?ie, eaoaae?a o??o?a?/ii? noiiaoieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny 11 o?aaiy 1999 ?. i 15 aiae. ia
can?aeaii? niaoe?ae?caaii? a/aii? ?aaee Ae35.600.01 o Euea?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (290010, i.Euea?a, aoe Iaea?nueea,
69)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (290010, i.Euea?a, aoe N?/iaeo
no??eueoe?a, 6)

Aaoi?aoa?ao ?ic?neaiee 10 ea?oiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?caaii? a/aii? ?aaee
*oee?i N.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Oai?? c ai?eii-caiaeueieie i?ioeanaie
uaeaiii-eeoeaai? ae?eyiee neeaaeathoue cia/iee a?aenioie a?ae caaaeueii?
e?eueeino? o??o?a?/ieo noiiaoieia?/ieo oai?eo. Niinoa??aa?oueny
oaiaeaioe?y aei ?o c?inoaiiy. Ca aeaieie Oeiioa?aa A.A. (1995), ??no
/enea iaoe??io?a ?c caiaeueieie caoai?thaaiiyie iaee//y e oe? c 1969 ii
1994 ??. noaiiaea a?ae 53.5 aei 68.4%. Oa ae naia a?aei?/a? e Eiceia
A.A. Cie?aia, a 1965 ?. e?euee?noue oai?eo c aino?ith iaeiioiaaiiith
?ioaeoe??th neeaaeaea 25.8% a?ae caaaeueiiai /enea aini?oae?ciaaieo, a a
1994 ?. – aaea 44.8%.

Na?aae caiaeueieo caoai?thaaiue oe??? ae?eyiee /anoioa iaeiioiaaiieo
inoaii??e?o?a uaeai neeaaea? a?ae 15 aei 33% (Oa?ai?iaeneee A.A., 1984;
Iaoeaiia ?.Oe. oa ni?aaao., 1990; Eiceia A.A. oa ni?aaao., 1995;
Ea?i?iaoeue A.A., 1996), o?aaiaoe/ieo – 11,2-33,3% (Aaaeaiia I.I. e
ni?aaao., 1986; Eoeueyiaiei A.E., 1986; O?acaeei AE.A. e ni?aaao.,
1989).

Iaie anoaiiaeaii, ui ca ia??iae c 1990 ii 1996 ??. o a?aeae?eaii?
uaeaiii-eeoeaai? o??o?a?? EIEE iaeiioiaaiiee inoaii??e?o uaeai noaiiaea
18.6% – 24% a?ae caaaeueii? e?eueeino? oai?eo ai?eii-caiaeueieie
i?ioeanaie uaeaiiai-eeoeaai? ae?eyiee, o?aaiaoe/iee o?aieyany o 11.8% –
13% aeiaaee?a ceai?a uaeaiiaeo e?noie.

Iacaaaeath/e ia canoinoaaiiy no/anieo iaoiae?a e?eoaaiiy, eiia??i?noue
?icaeoeo ??ciiiai?oieo oneeaaeiaiue oeueiai caoai?thaaiiy caeeoa?oueny
aeineoue aenieith. Na?aae ieo iaea?eueo /anoei ? ia?ao?ae aino?i? oace
caiaeaiiy a o?ii?/io, yea cono??/a?oueny a 13-25% oai?eo (Oeaiia E.I.,
1982; Ua?aaothe Ae.E., 1987). A aeayeeo aeiaaeeao ooai?aiiy aaeeeeo
naeaano??a i?e iaeiioiaaiiiio inoaii??e?o? ni?e/eith? iaoieia?/iee ceai
ieaeiuei? uaeaie; aeeoociee ai?eii-aeano?oeoeaiee i?ioean i?e
o?aaiaoe/iiio inoaii??e?o? iiaea coiiaeoe ii?ooaiiy eiinie?aeaoe??
a?aeeaie?a uaeaie, ooai?aiiy oeaiiai noaeiao.

Aiane?aeie ii?ooaiiy o aiaieu? caiaeaiiy e?iaiiinoa/aiiy, /a?ac ci?ie a
noaeeiao i?e?ioee?eoeyoi?iiai ?onea, iia??oaiiy ?aieia?/ieo aeanoeainoae
e?ia? (Ieueoaaneee A.A. oa ni?aaao., 1982; Ieiaeen E.N., 1982; Aoaei
I.A., 1987; Eocei I.E., 1990) aeii’ycaaa e aeiaaiia aaaaeaiiy
aioea?ioee?a ia caaaeaee aeicaiey? noai?eoe aeinoaoiuei aenieo ?o
eiioeaio?aoe?th aeey aoaeoeaiiai aieeao ia caoaeiee?a oeueiai
caoai?thaaiiy aaciina?aaeiuei o aiaieu? caiaeaiiy. Ca?eueoaiiy aeice
noai?th? iaaaciaeo ?o caaaeueiioiene/ii? ae??, ?icaeoeo aeenaaeoa??ico,
aea?a?/ieo ?aaeoe?e (Iaaaoei N.I., Oiieia E.I., 1982; Nieiaueaa I,I. oa
ni?aaao., 1984; Saul Z., Bahn etal, 1991).

Aeieea? iio?aaa a canoinoaaii? aeiaeaoeiaeo cania?a, ni?eyth/eo
aeaiiioaaiith oeeo e?e?a a ae?eyiee c i?aeaeuaiith eiioeaio?aoe??th
i?e?ii?aai?ci?a.

Ca`ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeeiiaia
aeine?aeaeaiiy ? o?aaiaioii iaoeiai-aeine?aeii? ?iaioe eaoaae?e
o??o?a?/ii? noiiaoieia?? Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo “Aeaoi?iaoe?? eeoeaaiai neaeaoo o ae?oae c a?iaeaeaieie
iac?iuaiiyie aa?oiuei? aoae ? i?aeiaa?iiy aei ? i?ney o??o?a?/iiai
e?eoaaiiy oa iaoiaee ?o ei?aeoe??”. ? aea?ae?a?no?aoe?? 02010793.

Iaoa aeine?aeaeaiiy. I?aeaeueoe aoaeoeai?noue e?eoaaiiy oai?eo c
aino?ei iaeiioiaaiiei oa o?aaiaoe/iei inoaii??e?oii ieaeiuei? uaeaie
oeyoii canoinoaaiiy eiia?iiaaiiai ?iiioi?aco aioea?ioee?a c aeeiaeneaeii
oa aaia?eio.

Caaea/? aeine?aeaeaiiy.

1. Aeine?aeeoe a aenia?eiaio? iiaeeea?noue noai?aiiy cia/ii? oa o?eaaei?
eiioeaio?aoe?? aioea?ioee?a aaciina?aaeiuei o aiaieu? caiaeaiiy i?e ?o
aaaaeaii? a ?ic/ei? aeeiaeneaeo ca aeiiiiiaith ?iiioi?aco.

2. I?inoaaeeoe a aenia?eiaio? ca i?ioeanii iaa?iiaaeaeaiiy aeeiaeneaeo a
caiaeueii-iae?ioe/i?e e?noeia?e oeaiei? a ii??aiyiii? c? caei?iaith.

3. ?ic?iaeoe oa ai?iaoaaoe iaoiaeeeo iaeiiiiiaioiiai canoinoaaiiy
?iiioi?aco aioea?ioee?a a ?ic/ei? aeeiaeneaeo c aioo??oiueioeaieiiei
?iiioi?acii aaia?eio a eiiieaeniiio e?eoaaii? aino?eo iaeiioiaaiieo oa
o?aaiaoe/ieo inoaii??e?o?a ieaeiuei? uaeaie, i?iaanoe ii??aiyeueio
ioe?ieo c io?eiaieie ?acoeueoaoaie i?e o?aaeeoe?eiiio e?eoaaii?.

4. I?ine?aeeoaaoe a aenia?eiaio? ia oaa?eiao (e?ieyo), a ii??aiyeueiiio
aniaeo?, aeeiai?eo iaoiii?oieia?/ieo ci?i ?ioaeoe?eii-caiaeueiiai,
ai?eii-iae?ioe/iiai i?ioeano a e?noeia?e oeaiei? i?ae aieeaii
?ic?iaeaiiai iaoiaeo e?eoaaiiy.

5. I?inoaaeeoe ca aeieeiaiiyi o?ii?/ieo aeano?oeoeaieo oi?i
iaeiioiaaiiiai inoaii??e?oo ieaeiuei? uaeaie i?e canoinoaaii?
eiia?iiaaiiai ?iiioi?aco aioea?ioee?a c aeeiaeneaeii oa aaia?eio i?ae
/an e?eoaaiiy oeueiai caoai?thaaiiy a aino?ee ia??iae c ??ciith
aaaee?noth ia?aa?ao.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa i?e e?eoaaii? aino?eo
iaeiioiaaiieo oa o?aaiaoe/ieo inoaii??e?o?a ieaeiuei? uaeaie canoiniaaii
aioo??oiueioeaieiiee ?iiioi?ac aaia?eio a ii?aeiaii? ?c cae/aeiei
?iiioi?acii aioea?ioee?a c aeeiaeneaeii (“Niin?a e?eoaaiiy inoaii??e?oo
uaeaie”, Iaoaio Oe?a?ie 19647A). A ee?i?/ieo oiiaao i?inoaaeaii ca
aeieeiaiiyi o?ii?/ieo aeano?oeoeaieo oi?i iaeiioiaaiiiai inoaii??e?oo,
ca?aeii ee?i?ei-?aioaaiieia?/ii? eeaneo?eaoe?? Nieiaueaaa I. ?
Ooaeiy?iaa E. (1979), i?e canoinoaaii? ?ic?iaeaii? iaoiaeeee i?ae /an
e?eoaaiiy oeueiai caoai?thaaiiy a aino?ee ia??iae c ??ciith aaaee?noth
ia?aa?ao. Aeine?aeaeaii a aenia?eiaio? aieea aeeiaeneaeo ia i?ioean
aea??eiaiai iaa?iiaaeaeaiiy e?ieii?oeeio a caiaeai?e e?noeia?e oeaiei? o
ii??aiyii? ?c caei?iaith.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeaii oa ai?iaiaaii
niin?a e?eoaaiiy iaeiioiaaiieo oa o?aaiaoe/ieo inoaii??e?o?a ieaeiuei?
uaeaie (Iaoaio Oe?a?ie 19647A – 1998) ?c canoinoaaiiyi eiia?iiaaiiai
?iiioi?aco aioea?ioee?a, aeeiaeneaeo oa aaia?eio. A?i ? caaaeueii
aeinooiiei, aaeaioiaaiei aeey ai?iaaaeaeaiiy ? canoinoaaiiy a ?aaeueieo
oiiaao i?aeoe/ii? eaiee nenoaie ioi?iie caei?ia`y, iie?auo? ?acoeueoaoe
e?eoaaiiy oai?eo c aeaiith iaoieia??th. ?acoeueoaoe aeine?aeaeaiiy
canoiniaothoueny a i?aeoe/i?e ?iaio? ee?i?ee o??o?a?/ii? noiiaoieia??
Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (EAeIO) ?i.
Ae.Aaeeoeueeiai, a oaeiae o a?aeae?eaiiyo uaeaiii-eeoeaai? o??o?a??
Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, e?ea?i? oaeaeei? iaaee/ii?
aeiiiiiae i.Eueaiaa, ee?i?ee o??o?a?/ii? noiiaoieia?? Iaeanueeiai
iaaee/iiai oi?aa?neoaoo, a?aeae?eaiiy o??o?a?/ii? noiiaoieia??
Iaeanueeiai IAe? noiiaoieia?? IIC Oe?a?ie, a?aeae?eaii? o??o?a?/ii?
noiiaoieia?? a?enueeiaiai ie?oaeiiai oieoaeth (i.Iaeana). Iniiai?
iieiaeaiiy aeena?oaoe?? aeei?enoiaothoueny i?e /eoaii? eaeoe?eiiai eo?no
? i?iaaaeaii? i?aeoe/ieo caiyoue oa nai?ia??a c o??o?a?/ii? noiiaoieia??
o EAeIO ?i. Ae.Aaeeoeueeiai.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iiaiiaai? iaiao?aei? iaoiaeeee
aeine?aeaeaiiy, i?iaaaeaia ia`?eoeaia ioe?iea ?ioi?iaoeaiino?
canoiniaaieo iaoiae?a ianoaaeaiiy i?e aino?iio o?aaiaoe/iiio oa
iaeiioiaaiiiio inoaii??e?oao ieaeiuei? uaeaie. Aeena?oaioii cae?eniai?
aiae?c ? ?ioa?i?aoaoe?y aeaieo aenia?eiaioaeueii-ee?i?/ieo
aeine?aeaeaiue ? iaa?oioiaaia e?eoaaeueia oaeoeea. ?aeay ?ic?iaee
eiia?iiaaiiai ?iiioi?aco aioea?ioee?a c aeeiaeneaeii oa aaia?eio
iaeaaeeoue Iie?eeo I.ss. Aaoi?ii aea/aii aoaeoeaiinoue ?ic?iaeaii?
iaoiaeeee a oiiaao aenia?eiaioo oa ee?i?ee. Ca o/anoth aeena?oaioa
i?iaaaeaii eiiieaen aeiee?i?/ieo ? ee?i?/ieo aeine?aeaeaiue aeanoeainoae
aeeiaeneaeo. Na??y aenia?eiaioaeueieo aeine?aeaeaiue aaoi?ii aeeiiaia
naiino?eii. Aeiyoie noaiiaeoue eeoa Iaoaio Oe?a?ie, yeee ? ?acoeueoaoii
ni?eueii? ?iaioe eieaeoeao aaoi??a. Ni?aaaoi?noai ?ioeo aeine?aeiee?a o
iaoeiaeo i?aoeyo, iioae?eiaaieo ca iaoa??aeaie aeena?oaoe??, iieyaa?
caeaa?eueoiai o ?o eiinoeueoaoeai?e aeiiiiic? oa ni?ao/ano? a
ae?aaiinoe/ii-e?eoaaeueiiio i?ioean?.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy
aeena?oaoe?eii? ?iaioe aeeeaaeai? e iaaiai?ai? ia can?aeaiiyo
Euea?anueeiai iaeaniiai oiaa?enoaa noiiaoieia?a o 1996 ?., ni?eueieo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo e?ea??a a?aeae?eaiiy uaeaiii-eeoeaai?
o??o?a?? Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, Euea?anueei? i?nueei?
ee?i?/ii? e?ea?i? oaeaeei? iaaee/ii? aeiiiiiae oa ni?a?ia?oiee?a
eaoaae?e o??o?a?/ii? noiiaoieia?? EAeIO ?i.Ae.Aaeeoeueeiai, aena?oeai? a
iaoa??aeao iaoeiai? eiioa?aioe??, i?enay/aii? 20-??//th eaoaae?e
aeeoy/i? noiiaoieia?? EAeIO (i.Euea?a, 1996 ?.), oa ?anioae?eainueei?
iaoeiai-i?aeoe/ii? eiioa?aioe?? “Aeooaeuei? ieoaiiy noiiaoieia??” a 1997
?., i.Iaeana.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 9 ae?oeiaaieo
i?aoeue, c ieo 3 noaoo? o iaoeiaeo aeo?iaeao, io?eiaii 1 Iaoaio Oe?a?ie.

No?oeoo?a ? ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 151
noi??ieao, neeaaea?oueny c? anooio, 5 ?icae?e?a, aeniiae?a, nieneo
aeei?enoaieo e?oa?aoo?ieo aeaea?ae; aeiiiaiaia aeiaeaoeii ?c eii?yie
aeo?a ai?iaaaeaeaiiy (5). Oaaeeoe? (26), ?enoiee (48) oa aeienee c
?noi??e oai?ia (5), a?ae?ia?ao?/iee iieac/ee (288 aeaea?aea e?oa?aoo?e),
aeiaeaoie (1).

INIIAIEE CI?NO

Iaoa??ae ? iaoiaee aeine?aeaeaiiy

Aenia?eiaioaeueia aeine?aeaeaiiy neeaaeaeinue ?c aeaio /anoei. Ia 68
aacii?iaeieo e?ieyo-naioeyo, o a?oe? 6-8 i?nyoe?a, ye? ciaoiaeeeenue ia
cae/aeiiio oo?eiaii? a?aa??th, a?aeoai?thaaee ?ioaeoe?eii-aea?a?/iee
inoaii??e?o ieaeiuei? uaeaie ca iaoiaeeeith N.I.Aea?eaeaiiaa, 1940.

A ia?o?e /anoei? aenia?eiaioo aecia/aee eiioeaio?aoe?th e?ieii?oeeio
iaoiaeii aeeooc?? a aaa? ca iaoiaeeeith Ae?aaeeiie ?.I. oa Neiaeueieeiaa
A.I., 1951, a caiaeueiiio aenoaeao?, a caei?ia?e e o?aaeai?e
inoaii??e?oii e?noeia?e oeaiei? ieaeiuei? uaeaie. Aeey oeueiai aoei
aeeiiaii aea? na??? aeine?ae?a. Ia 4-5 aeiao aino?iai
aenia?eiaioaeueiiai inoaii??e?oo oaa?ei aoei iiae?eaii ia 3 a?oie. A
ia?o?e – e?ieii?oeei aaiaeeee aeii’ycaai – 0,5 ie 30% ?ic/eio (150 ia).
A ae?oa?e oa o?ao?e a?oiao i?noeaai, ca aeiiiiiaith ?iiioi?aco. Aeey
oeueiai ei?enooaaeenue aia?aoii aeey aaeueaai?caoe?? “Iioie-1”.
Aeine?aeaeaiiy ai?noo aioea?ioeeo i?iaiaeeeinue i?ney aaaaeaiiy 150 ia
(0,5 ie 30% ?ic/eio) e?ieii?oeeio oeei iaoiaeii c aiiaeo. Ia?aae oei, ye
aaanoe aioea?ioee oaa?eiai, ye? neeaaeaee o?aoth a?oio, eiai
iiia?aaeiuei ?ic/eiyee a 20% ?ic/ei? aeeiaeneaeo a ni?aa?aeiioaii? 1:1.
A o?ao?e na??? aeine?ae?a ia?oi? /anoeie aenia?eiaioo aecia/aee
e?euee?noue aeeiaeneaeo a e?noeia?e oeaiei? eiaeiiao?e/iei iaoiaeii ca
I.Aaiao, I.Aeai/oe, 1996.

A ae?oa?e /anoei? aenia?eiaioo i?inoaaeoaaee aeeiai?eo ia?aa?ao
aenia?eiaioaeueiiai inoaii??e?oo ieaeiuei? uaeaie a 28 i?aeaeine?aeieo
oaa?ei. A eiio?ieuei?e a?oi? (8 oaa?ei) e?eoaaiiy ia i?iaiaeeeinue. A
ia?oo i?aeaeine?aeio a?oio aoiaeeei 10 e?ie?a. ?i i?ney ?ice?eooy
aiiye?a i?iaiaeeeinue ?o i?ioaiiy ?ic/eiaie aioenaioee?a (oo?aoeee?iii,
i?e?ioeeaeii), a oaeiae ?iiioi?ac e?ieii?oeeio – 0,5 ie 30% ?ic/eio.
Caaaeueii canoiniaoaaee aeanainea?e?coth/? oa aieaaoaiiaoth/? i?aia?aoe
(0,2 ie ?ic/eio 1% aeeiaae?ieo c 0,2 ie 5% ?ic/eio aiaeuea?io). E??i
oiai, ia i?ioyc? 8-10 aei?a caaaeueii oaa?eie io?eioaaee ?i`?eoe??
e?ieii?oeeio – 0,5 ie 30% ?ic/eio aeii’ycaai 3 ?ace ia aeaiue. A ae?oa?e
i?aeaeine?aei?e a?oi? (10 e?ie?a) aeiiiaithaaee aeacai? oa?aiaaoe/i?
caoiaee aeaui ci?iaiith iaoiaeeeith ?iiioi?aco: e?ieii?oeei – 0,5 ie 30%
?ic/eio (150 ia) ?ic/eiyee o 20% ?ic/ei? aeeiaeneaeo (AeINI), o
ni?aa?aeiioaii? 1:1 oa i?eeeaaeaee cii/aio iei i?ieeaaeeo ia ae?eyieo
caiaeaiiy. Iaeii/anii aaiaeeee aaia?ei (1500 IAe) – a e?aeiao aaio aooa,
ia eo?n 7-8 i?ioeaaeo?. Eo?n aaeueaai?caoe?? ?icii/eiaee /a?ac 4 aei?
i?ney ?ice?eooy aiiye?a. Ioe?ithaaee aoaeoeai?noue canoiniaaiiai
e?eoaaiiy, aea/aee iaoiii?oieia?/i? ci?ie a e?nooe?. Aeey oeueiai e?ie?a
aeaiaeeee c aenia?eiaioo aeiaaiiei aaaaeaiiyi iia?o?yiiai aiaieo ia
7-ee, 14-ee, 21-ee, 30-ee aei?, /a?ac 1,5 oa 2 i?nyoe? a?ae ii/aoeo ?o
e?eoaaiiy. I?aia?aoe oa?aoaaee aaiaoienee?i-aiceiii ca Aai-A?ciiii. O
an?o aeine?aeao ?iaeee na??ei? c??ce c o?ea ieaeiuei? uaeaie, o?aaeaii?
inoaii??e?oe/iei i?ioeanii.

Ee?i?/i? aeine?aeaeaiiy oa ai?iaaoe?y ?ic?iaeaii? iaoiaeeee e?eoaaiiy
inoaii??e?o?a uaeai i?iaiaeeeenue ia aac? a?aeae?eaiiy uaeaiiai-eeoeaai?
o??o?a?? Euea?anueei? iaeanii? ee?i?/ii? e?ea?i? (EIEE) ii/eiath/e c
1994 ?ieo.

A aeaiue aini?oae?caoe?? oa a aeeiai?oe? oai?ei ?iaeany ?icai?iooee
aiae?c e?ia? oa i?iaiaeeeinue ?aioaaiieia?/ia aeine?aeaeaiiy ieaeiuei?
uaeaie. Aea/aeenue iieacieee, oa?aeoa?ecoth/? cn?aeath/o nenoaio e?ia?:
/an cn?aeaiiy e?ia?, oiea?aioi?noue ieacie aei aaia?eio, i?io?iia?iiaee
?iaeaen, /an ?aeaeueoeeo?eaoe??, o?a?eiiaai e?ia?, o?a?eiie?oe/io
aeoeai?noue. E?euee?noue O-e?ioioeeo?a aecia/aee ca aeiiiiiaith
A-?icaoeiooai?aiiy, A-e?ioioeeo?a – ii niiioaiiiio ?IE c ieoa/eie
a?eo?ioeeoaie. Ai?no ?ioiiaeiaoe?i?a A, G, M o ne?iaaooe? e?ia? oa neei?
aecia/aee ca iaoiaeii Mancini G. et al, 1965. E?euee?noue e?cioeeio a
neei? aecia/aee iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a aaa?iaiio aae? ca
iaoiaeeeith Eaa?aiiiiai? E.A., ??iieue?ai? C.A., 1966. Iaoa??aeii aeey
i?e?ia?ieia?/iiai aeine?aeaeaiiy neoaeea ai?no ai?eieo ?ai. Aiii
aeeth/aei ?aeaioeo?eaoe?th caoaeieea, aecia/aiiy /ooeeaino? i?e?ioei?e
aei aioea?ioee?a, i?ae?aooiie e?eueeino? i?e?iaieo o?e a 1 ie aenoaeaoo,
yeee a?aee ia aeine?aeaeaiiy c?aco i?ney ?ice?eooy aiiye?a, /a?ac 3, 6,
9 aei?a i?ney ?icii/aoi? aioea?ioeeioa?ai??.

Aea/aiiy aaiiaeeiai?ee o aiaieu? caiaeaiiy i?iaiaeeee ca aeiiiiiaith
?aia?aoa ?A-4-01, ii caaaeueiii?eeiyoiio niiniao ?a?no?aoe?? ?aia?ai ii
a?iiey?i?e iaoiaeeoe? c iica?ioiaei iaeeaaeaiiyi aeaeo?iae?a neiao?e/ii
a ae?eyioe? iaioaeueieo ioai??a, aeio?eioth/enue ?aeiiaiaeaoe?e
A.A.I?ioii/oeiaa, 1980. Aecia/aeenue cia/aiiy aiie?ooaeieo oa?aeoa?enoee
?aia?aie oa ?o iio?aei?.

Aoiinoaiiao??th i?iaiaeeee ca aeiiiiiaith i?eeaaeo “Yoiinoaiiao?”
YII-01oe iaoiaeii aaniethoieo aei???a ca ?aeiiaiaeaoe?yie Eiaeiiaie
I.E., 1989. Aeine?aeaeaiiy i?iaiaeeee ye ia aioe? uaeaie c iaoieia?/ieie
ci?iaie, oae ? ia caei?iaiio.

O??o?a?/ia ao?o/aiiy i?e e?eoaaii? aino?iai iaeiioiaaiiiai oa
o?aaiaoe/iiai inoaii??e?oo ieaeiuei? uaeaie aeeth/aei: aeaeaeaiiy coaa,
yeee aoa aeaea?aeii ?ioaeoe?? /e ia?aoeiaeaeaa ?aiiceoe?? a?aeeaie?a i?e
ceai?, ?icoei i’yeeo oeaiei a ?ac? aeieeiaiiy aanoeano /e oeaaiiie oa
i?iaaaeaiiy ae?ae?co ?aie. Iaia’yceiai ?iaeee ia??inoioii?th a i?noeyo c
ae?aaeaiith ?io?eueo?aoe??th ie?noy. E??i oiai, i?ecia/aee
aeanainea?e?coth/o, i?ioeiaa?yeiao, caaaeueiici?oeithth/o (a?oai?ie A,
N) oa aioeaaeoa??aeueio oa?ai?th. Aioea?ioeee i?ecia/aeenue ia i?ioyc?
8-10 aei?a aei ii?iae?caoe?? oaiia?aoo?e o?ea e i?eieiaiiy aeae?eaiiy
aiith. Oai?? c aaaeeei ia?aa?aii aino?iai iaeiioiaaiiiai inoaii??e?oo
io?eioaaee aeii`ycaai oeiae?i, i?ae eiio?ieai ?ioiia?aie, aeiaaiii
aaiaeeee e?iaicai?iieee (?aiiie?aethe?i, ?ic/ei ??iaa?a-Eieea).

A eiiieaeniiio e?eoaaii? oai?eo iniiaii? a?oie (47 /ie.) c aino?ei
iaeiioiaaiiei oa o?aaiaoe/iei inoaii??e?oii ieaeiuei? uaeaie canoiniaaii
?ic?iaeaio iaoiaeeeo. Nooue ?? iieyaa? a ii?aeiaii? eeane/iiai
?iiioi?aco aioea?ioee?a o ?ic/ei? 20% aeeiaeneaeo c iaeiiiiiaioiei
aioo??oiueioeaieiiei ?iiioi?acii aaia?eio, a iniia? yeiai eaaeeoue
i?eioeei aeaeo?iae?i?iaoe?? – iinooieaiiy a oeaieie i?aai?cio
oee?eoethth/eo a noaeeiiiio ?one? e?e?a i?ae aieeaii aeaeo?e/iiai iiey
iino?eiiai no?oio. Iaoiaeeea cae?enith?oueny ianooiiei /eiii: iaoe??io
ciaoiaeeoueny a eaaea/iio iieiaeaii? ia eooaooe?. Ia no?oiiiano/ee
aeaeo?iae, i?ae’?aeiaiee aei iiceoeaiiai iiethno (aiiaeo)
aaeueaaiiaia?aoo “Iioie-1” iaeeaaeathoue, c?iaeaio c 4-o oa??a ia?e?,
i?ieeaaeeo ieiuath 60 ni2, yea iiia?aaeiuei cii/o?oueny a 5-6 ie 20%
?ic/eio aeeiaeneaeo c ?aciaith aeicith aioea?ioeeo (1:1), u?eueii
i?eeeaaeathoue aei oe??e, aaciina?aaeiuei ia aioe? ai?eii-caiaeueiiai
aiaieua, oa o?enothoue aeioiaith iia’yceith. Ia aeaeo?iae, i?ae’?aeiaiee
aei iaaaoeaiiai iiethno aaeueaaiiaia?aoo, iaeeaaeathoue i?ieeaaeeo,
cii/aio a aeenoeeueiaai?e aiae? e o?enothoue ia caei?iaiio aioe?. Oai?ei
aaiaeyoue aeiaaiii, e?aiaeueii 10 000 IAe aaia?eio a 200-150 ie
?cioii?/iiai ?ic/eio oei?eaeo iao??th. I?ney iinooieaiiy a i?aai?ci
iaoe??ioa i?eaeecii 2/3 ia’?io ?ic/eio, ?icii/eia?oueny aaeueaai?caoe?y
i?e u?eueiino? aeaeo?e/iiai no?oio 0,05-0,2 ieA/ni2. O?eaae?noue naaino
30-35 oaeeei. Iaeii/anii i?iaiaeeoueny aaaaeaiiy oai?iio caeeoeiaiai
ia’?io o?c?ic/eio c aaia?eiii. Eo?n e?eoaaiiy neeaaea? a?ae 7 aei 10
i?ioeaaeo?; eiai i?ecia/aee /a?ac 4 aei? i?ney ?ice?eooy aiiye?a, i?e
ii?iaeuei?e oaiia?aoo?? o?ea.

Io?eiai? oeeo?ia? aeai? i?iaaaeaieo aeine?aeaeaiue aoee i?aeaeai?
noaoenoe/i?e ia?iaoe?. Aecia/aiiy aeinoia??iino? ??cieoe? io?eiaieo
?acoeueoao?a i?iaiaeeee ca oanoaie Nouethaeaioa oa O?oa?a /a?ac
eii`thoa?io i?ia?aio iaaeeei-noaoenoe/ieo ia/eneaiue InStat GraphPad
Software, 1993.

?ACOEUeOAOE AENIA?EIAIOAEUeIEO AeINE?AeAEAIUe

I?e aeii’ycaaiio aaaaeaii? e?ieii?oeeio, aeyaeoe eiai a
aeine?aeaeoaaiiio iaoa??ae? (caiaeueiiio aenoaeao?) aaeaaaeinue ia
i?ioyc? 6 aiaeei: 1.83(0.04 iea/ie – /a?ac 1 aiae., 0.74(0.06 iea/ie –
/a?ac 3 aiae., /a?ac 6 aiaeei ia aeciaany. A?eueo o?eaaei ciaoiaeeany
aioea?ioee a iueiio i?e eiai i?noeaaiio canoinoaaii? ca aeiiiiiaith
?iiioi?aco, aea eiioeaio?aoe?y i?e oeueiio aoea aeaui iaioith: 0.85(0.03
iea/ie – /a?ac 1 aiae., 1.76(0.9 iea/ie – /a?ac 3 aiae., 1.44(0.07
iea/ie – /a?ac 6 aiae. Cia/ii ??cieany ai?no i?aia?aoo i?e eiai
i?noeaaiio aaaaeaii? c 20% ?ic/eiii aeeiaeneaeo. Niinoa??aaeinue cia/ia
c?inoaiiy aioea?ioeeo a ?aiaaeo aeae?eaiiyo. E?ieii?oeei aeinyaaa
iaeneiaeueii? eiioeaio?aoe?? a aeine?aeaeoaaiiio iaoa??ae? /a?ac 1 aiae.
i?ney cae?i/aiiy naaino ?iiioi?aco -2.59(0.07 iea/ie e caeeoaany ia
aecia/eiiio ??ai? ia i?ioyc? 12 aiaeei: /a?ac 3 aiae. – 1.94(0.08
iea/ie, /a?ac 6 aiae. – 1.62(0.05 iea/ie (?0.5).

I?iaaaeai? aaeoa??ieia?/i? aeine?aeaeaiiy aeicaieeee aeyaeoe a 48
(96,3%) oai?eo aa?iaieo caoaeiee?a caoai?thaaiiy, eeoa a 2 (3,7%) iin?a
i?aeaeine?aeiiai iaoa??aeo a cae/aeieo oiiaao aeaa a?ae’?iiee
?acoeueoao, ui aoei iia’ycaii c aiaa?iaiei oa?aeoa?ii ?inoo i?e?ia?a.
Aei e?eoaaiiy e?euee?ni? iieacieee ian?iai?iiy ai?eieo ?ai aa?iaieie
i?e?ii?aai?ciaie a iaoe??io?a eiio?ieueii? e iniiaii? a?oi aoee
i?eaeecii iaeiaeiaeie e neeaaeaee 107-108 i?e?ii?aai?ci?a a iaeiiio
a?ai? ?aiaaeo aeae?eaiue. *a?ac 3 aei? a?ae ii/aoeo aaaaeaiiy oai?ei
iaio a?oi caaaeueii e?ieii?oeeio oeae iieaciee cieceany aei 105-106. Ia
4 aeaiue i?ney ?ice?eooy aiiye?a e?eoaaiiy oai?eo iniiaii? a?oie aoei
aeiiiaiaii eiia?iiaaiei ?iiioi?acii e?ieii?oeeio c aeeiaeneaeii oa
aaia?eio. *a?ac 6 ? 9 ae?a aeyaeyeanue nooo?aa ??cieoey a e?euee?no?
i?e?ia?a a 1 a?ai? ?aiaaeo aeae?eaiue a eiio?ieuei?e oa iniiai?e a?oiao:
105, 103-104 e 102-103, 100-101 a 1 a?ai? aenoaeaoo a?aeiia?aeii.

Ia?ao?ae caoai?thaaiiy a o?ii?/ii-aeano?oeoeaio oi?io aoa iaieio/ei i?e
aaaeeiio ia?aa?ao caoai?thaaiiy. Aoaeo a?ae eiiieaeniiai e?eoaaiiy i?e
oeueiio iieyaaa o iiia?aaeaeaii? cia/iiai iioe?aiiy inoaiiae?ico,
ooai?aiiy aaeeeeo naeaano??a oa o oaeaeo?e e?ea?aeaoe?? ee?i?/ieo
neiioii?a caoai?thaaiiy. A iniiai?e a?oi? o?ii?/iee aeano?oeoeaiee
inoaii??e?o ?icaeioany a 7 iaoe??io?a – 30,4%. A ieo niinoa??aaany a
aino??e oac? inoaii??e?oo aaaeeee ia?aa?a caoai?thaaiiy. A 4 aeiaaeeao
(17,4%) o?ii?/iee i?ioean iaa aiaieuaaee oa?aeoa? c ooai?aiiyi ae??aieo
naeaano??a, ye? aeoiaeeee c a?aioeyoe?yie /a?ac ii?eoeaaee o?ae,
e?coaaee aai aeaeaeyeenue o??o?a?/iei oeyoii. A 3 (13,0%) oai?eo
c`yaeeenue iciaee e?oe/ii? oi?ie o?ii?/iiai aeano?oeoeaiiai caiaeaiiy a
e?noeia?e oeaiei?, aeey e?eoaaiiy yeiai ia iio?aaoaaeinue iia?aoeaiiai
ao?o/aiiy. A 16 oai?eo (69,5%), ye? aoee c eaaeei oa na?aaeiuei?
aaaeeino? ia?aa?aii caoai?thaaiiy, niinoa??aaeinue iaeoaeaiiy, oiaoi
ee?i?ei-?aioaaiieia?/ieo iciae o?ii?/iiai inoaii??e?oo a ieo ia
aeyaeaii.

O oai?eo eiio?ieueii? a?oie ia?ao?ae caoai?thaaiiy a o?ii?/io oaco
a?aei?/aany /ano?oa – a 63.6% oai?eo. I?e/iio iaeiioiaaiiee inoaii??e?o
a oe?e oac? ia??aeei noi?iaiaeaeoaaany cia/iith aeano?oeoe??th oa
ae?aaeaiith naeaano?aoe??th o?aaeaii? e?noee – a 18,1% oai?eo. A ieo,
i?ney aeaeaeaiiy cia?oa?ei? e?noee, aeieeea iio?aaa ieanoe/iiai
cai?uaiiy ooai?aieo e?noeiaeo aeaoaeo?a. Oae? oai?? a aino??e oac? iaee
aaaeeee ia?aa?a caoai?thaaiiy. O 2 c 5 oai?eo c na?aaeiueith aaaee?noth
aino?iai i?ioeano a?aeaoaaany ia?ao?ae inoaii??e?oo a o?ii?/io oaco aac
ooai?aiiy naeaano??a. A 3 iaoe??io?a a?eii aei 6 ?ie?a (13,6%) ii?yae c
aeano?oeoeaieie yaeuaie a e?noeia?e oeaiei? niinoa??aaeinue ?ic?inoaiiy
ia??inoo c iiyaith aeaoi?iaoe?? eiioo??a ieaeiuei? uaeaie. A iaeiiai
oai?iai (4,5%) c eiio?ieueii? a?oie noaany iaoieia?/iee ceai. O an?o
aeiaaeeao iiyae o?ii?/iiai aeano?oeoeaiiai inoaii??e?oo (e?oe/ia oi?ia)
i?e e?eoaaii? ia iio?aaoaaeinue o??o?a?/iiai ao?o/aiiy, aoei canoiniaaii
eiina?aaoeaio oa?ai?th.

I?e o?aaeeoe?eiiio e?eoaaii? o?aaiaoe/iiai inoaii??e?oo ia caaaeaee
aaeaaaeinue oaeaeei e?ea?aeoaaoe neiioiie caiaeaiiy oa iiia?aaeeoe
?oei?ai? i?ioeane a nai?e e?nooe? (32.1%), a 53.6% aeiaaee?a a?aei?/aii
niia?eueiaiiy eiinie?aeaoe?? oeaie?a ieaeiuei? uaeaie. A 7 (25%) c 28
aeine?aeaeaieo aeieeei iaaii?iiy ioi/oth/eo uaeaio i’yeeo oeaiei. O an?o
oai?eo iniiaii? a?oie aoei iiia?aaeaeaii iae?ic ua iao?aaeaii?
ai?eii-iae?ioe/iei i?ioeanii e?noee. Eeoa a 25% aeiaaee?a iaei i?noea
niia?eueiaia ooai?aiiy e?noeiai? iicie?. I?e/eio oeueiai ie iia’yco?ii c
iayai?noth a e?i?? ceaio a oaeeo oai?eo cia/ieo ca ianyaii oeaie?a
(a?eueoeo 2 ni), ye? a ieo ooai?eeenue ia iiiaio o?aaie. Ii?yae ?c
cieeiaiiyi neiioii?a caoai?thaaiiy ci?ithaaeenue oaeiae aeai?
ia’?eoeaieo iaoiae?a aeine?aeaeaiiy. Aiie i?aeoaa?aeaeothoue aoaeo
?ic?iaeaii? iaoiaeeee.

A oai?eo iaio ii??aiyeueieo a?oi, i?ney cae?i/aiiy e?eoaaiiy,
ii?iae?coaaeinue caaaeueia /enei eaeeioeeo?a. Iaeiae e?euee?noue
e?ioioeeo?a a e?ia? oa ie?ai? oaeoi?e i?noeaai? ?acenoaioiino? a neei?
oeeo oai?eo aeaui ??cieeenue (Oaae. 1). I?ney cae?i/aiiy eo?no
eiia?iiaaiiai ?iiioi?aco, i?ae aieeaii aaia?eio ii?iae?coaaeanue
cn?aeath/a aeanoea?noue e?ia? oa i?enei?eany o?a?eiie?c. A eiio?ieuei?e
a?oi? i?ney caaa?oaiiy e?eoaaiiy eiioeaio?aoe?y caaaeueiiai o?a?eiiaaio
e?ia? aoea aeaui caaeuaiith – 5.2(0.2 a/e (?Oaaeeoey 1. Aeeiai?ea ci?i iieaciee?a ?ioi?oaoo a oai?eo c aino?ei inoaii??e?oii ieaeiuei? uaeaie. Iieacieee A ?iciae aino?iai I?ney caaa?oaiiy iniiaiiai eo?no e?eoaaiiy ?1 ?ioi?oaoo inoaii??e?oo Iniiaia a?oia (i=47) M(m Eiio?ieueia a?oia (i=50) M(m E?ia O-e?ioioeeoe% 52(1.54 55 (1.36 47 (0.91 ?1AIIOAOe?ss Iie?ee I.ss. E?eoaaiiy inoaii??e?o?a ieaeiuei? uaeaie ?c canoinoaaiiyi eiia?iiaaiiai ?iiioi?aco aioea?ioee?a c aeeiaeneaeii oa aaia?eio. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.22. - Noiiaoieia?y. - Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Ae.Aaeeoeueeiai, i.Euea?a, 1999. Aenia?eiaioaeueii ia aacii?iaeieo e?ieyo aea/aii aieea aeeiaeneaeo (AeINI) ia i?ioean iaeiie/aiiy aioea?ioee?a o aiaieu? ai?eii-iae?ioe/iiai caiaeaiiy, i?aeoaa?aeaeaii aeioe?euei?noue ii?yae ?c caaaeueiei i?noeaaiai canoinoaaiiy aioea?ioee?a aeey caaacia/aiiy iioeiaeueii? ?o eiioeaio?aoe?? a o?aaeai?e uaeai?. I?inoaaeaii ia oaa?eiao ii?oieia?/i? ci?ie a e?noeia?e oeaiei? a oiiaao ai?eii-iae?ioe/iiai caiaeaiiy i?e aeei?enoaii? eiia?iiaaiiai ?iiioi?aco, nooue yeiai iieyaa? a ii?aeiaii? eeane/iiai ?iiioi?aco aioea?ioeeo a ?ic/ei? 20% aeeiaeneaeo c iaeiiiiiaioiei aioo??oiueioeaieiiei ?iiioi?acii aaia?eio. Aoaeoeai?noue ?ic?iaeaii? iaoiaeeee i?aeoaa?aeaeaii i?e ?? aeei?enoaii? i?ae /an e?eoaaiiy 47 oai?eo c aino?eie inoaii??e?oaie ieaeiuei? uaeaie c ??ciith aaaee?noth ia?aa?ao. Nei?ioeany oa?i?i e?eoaaiiy oai?eo oa a?aenioie oneeaaeiaiue. Iniiai? ?acoeueoaoe i?aoe? ciaeoee i?aeoe/ia ai?iaaaeaeaiiy. Eeth/ia? neiaa: inoaii??e?o ieaeiuei? uaeaie, aeeiaeneae, aioea?ioee, aaia?ei, eiia?iiaaiee ?iiioi?ac. AIIIOAOeEss Iie?ee I.ss. Ea/aiea inoaiieaeeoia ieaeiae /aethnoe n eniieueciaaieai eiiaeie?iaaiiiai eiiioi?aca aioeaeioeeia n aeeiaeneaeii e aaia?eia. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.22. - Noiiaoieiaey. - Eueaianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. Ae.Aaeeoeeiai, a.Eueaia, 1999. Aeenna?oaoeey iinayuaia aii?ino oniaa?oainoaiaaiey ea/aiey iaeiioiaaiiuo e o?aaiaoe/aneeo inoaiieaeeoia ieaeiae /aethnoe. A yenia?eiaioa, ia iiaeaee eioaeoeeiiii-aeea?ae/aneiai inoaiieaeeoa ieaeiae /aethnoe o e?ieeeia, eco/aii aeeyiea aeeiaeneaea (AeINI) ia i?ioeann iinooieaiey aioeaeioeeia a i/aa aiieii-iae?ioe/aneiai ainiaeaiey. I?e ianoiii aaaaeaiee, n iiiiuueth eiiioi?aca, eeieiieoeeia, ?anoai?aiiiai a AeINI, iaaethaeaeinue cia/eoaeueiia iaeiieaiea i?aia?aoa a ii?aaeaiiie inoaiieaeeoii /aethnoiie einoe n aeinoiaa?iie ?acieoeae eiioeaio?aoeee a i/aaa ainiaeaiey a n?aaiaiee n iaiia?aaeaeaiiie oeaiueth. Iiaeoaa?aeaeaaony aeeyiea aeeiaeneaea ia yoio i?ioeann. A iia?aaeaeaiiie einoe iaaethaeaeanue aai caaea?aeea e aieaa aeeeoaeueiia auaaaeaiea a n?aaiaiee ni caei?iaie. I?ineaaeaiu ii?oieiae/aneea eciaiaiey a einoiie oeaie aeeaioiuo a oneiaeyo aiieii-iae?ioe/aneiai ainiaeaiey i?e eniieueciaaiee eiiaeie?iaaiiiai eiiioi?aca, nouiinoue eioi?iai ninoieo a ni/aoaiee eeanne/aneiai eiiioi?aca aioeaeioeea a ?anoai?a 20% aeeiaeneaea n iaeiia?aiaiiui aioo?eoeaiaaui eiiioi?acii aaia?eia, eioi?ue aaiaeeee aioo?eaaiii Iiae aeeyieai ?ac?aaioaiiie iaoiaeeee auno?aa eeeaeaee?iaaeenue eeeie/aneea neiioiiu caaieaaaiey, oeo/oaeenue iieacaoaee e?iae, noeioee?iaaeanue ?aia?aoeaiay ?aaaia?aoeey einoe, i?aaeioa?auaeenue a iae au?aaeaiiua aeano?oeoeaiua i?ioeannu. Aooaeoeaiinoue yoie iaoiaeeee iiaeoaa?aeaeaia i?e aa eniieueciaaiee ai a?aiy ea/aiey 47 aieueiuo n ino?uie iaeiioiaaiiuie e o?aaiaoe/aneeie inoaiieaeeoaie ieaeiae /aethnoe. Oniaoiua ?acoeueoaou iieo/aiu i?e i?eiaiaiee eiiaeie?iaaiiiai eiiioi?aca a ia/aea caaieaaaiey. Ia?aoiae ino?iai iaeiioiaaiiiai inoaiieaeeoa a o?iie/aneoth aeano?oeoeaioth oaco iaaethaeaeny i?e oyaeaeii i?ioaeaiee ainiaeeoaeueiiai i?ioeanna. Yooaeo io ea/aiey, aeiiieiaiiiai ?ac?aaioaiiie iaoiaeeeie eiiaeie?iaaiiiai eiiioi?aca, caeeth/aeny a i?aaeioa?auaiee cia/eoaeueiiai ?ani?ino?aiaiey iae?ica ieaeiae /aethnoe, a auno?aeoae eeeaeaeaoeee eeeie/aneeo neiioiiia. Ai anao neo/ayo eaaeie e n?aaeiae oyaeanoe i?ioaeaiey caaieaaaiey oaeaeinue i?aaeioa?aoeoue aai ia?aoiae a o?iie/aneoth noaaeeth. Oaeaea iieo/aiu iieiaeeoaeueiua ?acoeueoaou a eeeieea i?e ea/aiee aieueiuo o?aaiaoe/aneei inoaiieaeeoii, iieo/aaoei a i?aaeeiaeaiiie eiiaeiaoeee aioeaeioeee, aeeiaeneae e aaia?ei. A n?aaiaiee n eiio?ieueiie a?oiiie auee auno?aa eeeaeaee?iaaiu eeeie/aneea neiioiiu caaieaaaiey, i?aaeioa?auaia naeaano?aoeey einoe. A 75% neo/aaa oaeaeinue iaania/eoue naiaa?aiaiioth eiinieeaeaoeeth ioeiieia. O aieueiuo iniiaiie a?oiiu nie?aoeeenue n?iee noaoeeiia?iiai ea/aiey. Iniiaiua ?acoeueoaou ?aaiou iaoee i?aeoe/aneia aiaae?aiea. Eeth/aaua neiaa: inoaiieaeeo ieaeiae /aethnoe, aeeiaeneae, aioeaeioee, aaia?ei, eiiaeie?iaaiiue eiiioi?ac. SUMMARY Mokryk O.Y. Treatment of osteomyelitis of the lower jaw with the employment of the combined antibiotics ionophoresis with dimexide and heparin. - Manuscript. Thesis for a degree of Candidate of medical science with speciality 14.01.22. - stomatology. - Lviv State Medical University, Lviv, 1999. On unblooded rabbits the influence of dimexide (DMSO) was experimentally studied to be upon the process of antibiotics accumulation in the focus of purulent inflammation. The necessity of both general and local antibiotics usage was confirmed to be for their optimal concentration in the injuried jaw. On animals the morphological changes were retraced to be in the bone tissue in the conditions of purulent inflammation using combined ionophoresis in 20% dimexide solution with single-moment intrafibrous ionophoresis of heparin. The effectiveness of the worked out methods was confirmed during the treatment of 47 patients with osteomyelitis of the lower jaw. Both the duration of treatment and the percentage of complications were reduced. The principal findings were put into practice. Key words: osteomyelitis of the lower jaw, dimexide, antibiotic, heparin, combined ionophoresis. PAGE PAGE 10 ?en. 1. Aeeiai?ea iaa?iiaaeaeaiiy e?ieii?oeeio a caei?ia?e oa o?aaeai?e ai?eii-iae?ioe/iei i?ioeanii e?nooe? i?e eiai aaaaeaii? ca aeiiiiiaith ?iiioi?aco c ?ic/eio 20% aeeiaeneaeo. E?eaa A - caei?iaa e?noea, e?eaa A - e?noea, o?aaeaia ai?eii-iae?ioe/iei i?ioeanii ?en. 2 Aeeiai?ea iaa?iiaaeaeaiiy aeeiaeneaeo a caei?ia?e oa caiaeai?e e?nooe?. Ii in? aanoeen - /an i?ney aaaaeaiiy a i?aai?ci aeeiaeneaeo (aiae). E?eaa A - caei?iaa e?noea, e?eaa A - e?noea, o?aaeaia ai?eii-iae?ioe/iei i?ioeanii. A A

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