IAOe?IIAEUeIEE OI?AA?NEOAO O?CE*IIAI AEOIAAIIss I NII?OO OE?A?IE

OEA*AIEI IAOAE?ss AIEIAeEIE??AIA

OAeE 796. 072.2

EI?AEOe?ss IIAeOETHTH*IAI AIEEAO NA*IAEIE IA NOAI AIOEIENEAeAIOII?
NENOAIE I?AAI?CIO I?E IAI?OAEAI?E I’ssCIA?E Ae?ssEUeIINO?

24.00.0I — Ie?ii?enueeee ? i?ioan?eiee nii?o

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaoe c

o?ce/iiai aeoiaaiiy ? nii?oo

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Iaoe?iiaeueiiio oi?aa?neoao? o?ce/iiai aeoiaaiiy ?
nii?oo Oe?a?ie ? Aea?aeaaiiio iaoeiai-aeine?aeiiio ?inoeooo? o?ce/ii?
eoeueoo?e ? nii?oo, Aea?aeaaiee eii?oao Oe?a?ie c o?ce/ii? eoeueoo?e ?
nii?oo.

Iaoeiaee ea??aiee — aeieoi? iaaeaaia?/ieo iaoe Nioeueneee Aaea??e
Eaii?aeiae/, i?ioani? eaoaae?e iaaeeei-a?ieia?/ieo iniia o?ce/ii?
eoeueoo?e ? nii?oo Iaoe?iiaeueiee oi?aa?neoao o?ce/iiai aeoiaaiiy ?
nii?oo Oe?a?ie, caa?aeoaa/ eaai?aoi??? niaoe?aeueiiai oa?/oaaiiy
Aea?aeaaiee iaoeiai-aeine?aeiee ?inoeooo o?ce/ii? eoeueoo?e ? nii?oo.

Io?oe?ei? iiiiaioe:

— aeieoi? iaaee/ieo iaoe, i?ioani?, Aa?e/ Aai?a?e ?aaaiiae/, caa.
eaoaae?e o?ce/ii? ?aaa?e?oaoe?? Iaoe?iiaeueiiai oi?aa?neoaoo o?ce/iiai
aeoiaaiiy ? nii?oo Oe?a?ie;

— aeieoi? iaaee/ieo iaoe, i?ioani?, A?eoi?ia Ieaen?e Iaaeiae/, caa.
a?aeae?eo ee?i?/ii? oa?iaeieia?? ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.
No?aaeanei Oe?a?ie.

I?ia?aeia i?aai?caoe?y: Euea?anueeee aea?aeaaiee ?inoeooo o?ce/ii?
eoeueoo?e, Aea?aeaaiee eii?oao Oe?a?ie c o?ce/ii? eoeueoo?e ? nii?oo, i.
Euea?a.

Caoeno a?aeaoaeaoueny “ 1  ”  aa?aniy 1999 ?. i 14 aiae. 30 oa. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.829.01 Iaoe?iiaeueiiai
oi?aa?neoaoo o?ce/iiai aeoiaaiiy ? nii?oo Oe?a?ie (252150, Ee?a-150,
aoe. O?ceoeueoo?e, 1).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Iaoe?iiaeueiiai
oi?aa?neoaoo o?ce/iiai aeoiaaiiy ? nii?oo Oe?a?ie (252150, Ee?a-150,
aoe. O?ceoeueoo?e, 1).

Aaoi?aoa?ao ?ic?neaiee “12 ” eeiiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaeaaia?/ieo iaoe, i?ioani?
?aauaiei E.ss.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue. Iiooe oeyo?a i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino?,
i?enei?aiiy i?io?eaiiy a?aeiiaethaaeueieo i?ioean?a i?ney cia/ieo
o?ce/ieo iaaaioaaeaiue caaaeaee aaaaeaeeny iaea?eueo aeooaeueieie
i?iaeaiaie o?c?ieia?? nii?oo. Iniaeeao caoe?eaaeai?noue oe? ieoaiiy
aeeeeeathoue o nii?o? aeueo aeinyaiaiue, o yeiio ii?yae ?c iino?eiei
aaeineiiaeaiiyi iaoiaeeee o?aioaaeueiiai i?ioeano ana a?eueoa oaaaa
i?eae?ey?oueny iiooeo iiaeeeainoae aeei?enoaiiy aeiaeaoeiaeo a?aiaaiieo
cania?a noeioeyoe?? nii?oeaii? i?aoeacaeaoiino?, ye? ia iaeaaeaoue aei
aeii?iao (A.I. Ac?cia, 1998, ?.A. Ai?eniaa, 1989, ?.Ae. Naeooea,
1989-1998, R. Collom, 1992, D.R. Lamb, 1991, M. Wiliams, 1997 ? ?i.).
Aecia/ii? cia/eiino? ?acii c oeei iaaoaa? c’ynoaaiiy ye aeeiai?ee, oae ?
oa?aeoa?o a?ieia?/ii? aeoeaiino? a i?aai?ci? aeayeeo i?ii?aeieo oa
e?ioeaaeo i?iaeoeo?a iaoaaie?cio, ye? a?aeiia?aeii aei caeiiii??iinoae
neeaaeieo i?aenenoaiieo aca?iia?aeiinei iiaeooue a?ae?a?aaaoe ?noioio
?ieue a aaeaioaoe?? i?aai?cio aei cia/ieo i’yciaeo iai?oaeaiue. Na?aae
oaeeo iaoaaie?o?a ia iniaeeao oaaao caneoaiaothoue i?iaeoeoe a?eeiaiai
iai?io, cie?aia, na/iaeia, uiaei aeoeaiino? yei? aei oaia??oiueiai /ano
iaeiie/aia cia/ia e?euee?noue aeaieo (A.TH. Aeiia?aaeia, 1994, I.O.
Eai?y, 1993, A.?. Eoeao, 1993, A.?. Noaa?ianueea, 1983, P. Fild, 1993,
R. Hendler, 1993, F. Wenke, 1995, G. Xingi, 1995).

Iaeiei ?c iii?oieo aoaeo?a na/iaeie ? ?? o/anoue ye aeoeaiiai
ia?aoiiethaa/a a?eueieo ?aaeeeae?a o aiaeyi?e oac? (H.H. Graper, 1993,
E. Niki, 1986, Y. Yamomoto, 1986) o iaoai?ciao aioeieneaeaioiiai caoenoo
a?ae ooeiaeaeoth/iai aieeao a?eueii?aaeeeaeueieo i?ioean?a, ye?
aeoeaothoueny o ee?oeiao aeoeaii ooieoe?iioth/eo i?aai?a i?ae /an
o?ce/ieo iaaaioaaeaiue (?.A. Aie/aai?nueeee, 1996, Ae.A. Aeyoeia, 1996,
P. Foxdahl, 1994, I. Frey, 1994, G. Karlsson, 1997, A. Knutson, 1994).

Oaeei /eiii, ooi/iaiiy oa?aeoa?o aieeao na/iaeie ia ooieoe?iiaeueiee
noai ye ie?aieo aioeieneaeaioieo, oae ? ?ioeo iaoaaie?/ieo ?
ooieoe?iiaeueieo iaoai?ci?a, ye? caaacia/othoue o?ce/io
i?aoeacaeaoi?noue, iiaea a?aee?eoe iia? i?aeoiaee aei iiooeo ?
canoinoaaiiy cania?a, ye? ni?eythoue i?aeaeuaiith iii?o i?aai?cio aei
iai?oaeaii? i’yciai? ae?yeueiino?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?eii? ?iaioe ? ?icae?eii oaie 2.3.7 “Aea/aiiy canoinoaaiiy
i?aia?ao?a i?e?iaeiiai oa neioaoe/iiai iioiaeaeaiiy o i?ioean?
i?aeaioiaee nii?oniai?a ca??ieo eiiaiae Oe?a?ie”, caaaeaiiai ieaio IAe?
c o?ce/ii? eoeueoo?e oa nii?oo ia 1998-2000 ?iee (? aea?ae?a?no?aoe??
096U10536).

Iaoa ?iaioe — aecia/eoe aieea na/iaeie ia ie?ai? iieacieee noaio
aioeieneaeaioii? nenoaie (AI-nenoaie) i?aai?cio i?ae /an iai?oaeaii?
i’yciai? ae?yeueiino? oa c o?aooaaiiyi c’yniaaieo iniaeeainoae ciaeoe
iiaeeea?noue i?aeaeuaiiy aoaeoeaiino? o?aioaaeueii? ? ciaaaeueii?
ae?yeueiino? nii?oniai?a o aeaeao nii?oo, ye? iio?aaothoue aeyao
aeo?eaaeino?.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe aieea iai?oaeaii? i’yciai? ae?yeueiino? ia aeeiai?eo na/iaeie
a e?ia? nii?oniai?a o c?noaaeaii? c aeeiai?eith eiioeaio?aoe??
i?ii?aeieo i?iaeoeo?a iaoaaie?cio aoaeaaiae?a ? aee??a o
a?aeiiaethaaeueiiio ia??iae?, a oaeiae ia iieacieee, ye?
oa?aeoa?ecothoue ye?ni? noi?iie ?ooiai? ae?yeueiino? nii?oniai?a.

2. Aeine?aeeoe ??aaiue aioeieneaeaioii? aeoeaiino? na/iaeie oa ?? aieea
ia noai ie?aieo eaiie AI-nenoaie a i?aai?ci?.

3. Aea/eoe aieea na/iaeie ia i?ioeane ieeniiai oinoi?eethaaiiy a
?cieueiaaieo i?oioiiae??yo.

4. Aecia/eoe aieea aenieeo eiioeaio?aoe?e na/iaeie ia o?ce/io
i?aoeacaeaoi?noue aenia?eiaioaeueieo oaa?ei.

5. Iaa?oiooaaoe aeioe?euei?noue aeei?enoaiiy eiie?aoiiai a?ieia?/ii —
aeoeaiiai caniao ? aeneiaeoe ?aeiiaiaeaoe?? c ei?aeoe?? noaio AI-nenoaie
(c o?aooaaiiyi aieeao ia oeae noai na/iaeie) aeey i?aeaeuaiiy iii?o
i?aai?cio nii?oniai?a aei iai?oaeaii? i’yciai? ae?yeueiino?.

Iaoeiaa iiaecia. Aeiaeaoeiai aei aaea a?aeiieo iaoeiaeo aeaieo i?i
a?ieia?/i? aoaeoe na/iaeie a i?aai?ci? ethaeeie aia?oa anoaiiaeaiee
aieea oeueiai iaoaaie?oo ia noai AI-nenoaie e?ia? nii?oniai?a i?ae /an
iai?oaeaii? i’yciai? ae?yeueiino? oa cai?iiiiiaaiee niin?a eiai
ei?aeoe?? (ca aeiiiiiaith e?ii?ai? eeneioe) aeey i?aeaeuaiiy
aoaeoeaiino? o?aioaaeueii? ae?yeueiino? nii?oniai?a o aeaeao nii?oo, ye?
iio?aaothoue aeyao aeo?eaaeino?.

Oai?aoe/ia ? i?aeoe/ia cia/ei?noue io?eiaieo ?acoeueoao?a. ?acoeueoaoaie
?iaioe, a oaeiae aeniiaeaie, ye? c?iaeai? ia ?o i?aenoaa?, aeiaaaeaii,
ui iaoeiaei iaa?oiooaaiiyi iiooeo cania?a i?aeaeuaiiy aoaeoeaiino?
o?aioaaeueii? ae?yeueiino? nii?oniai?a ca aeiiiiiaith
a?ieia?/ii-aeoeaieo ?a/iaei oa oaeoi??a oa?/oaaiiy ? aeai? i?i
iiaeoethth/ee aieea i?iaeoeo?a noano?aoiiai iaoaaie?cio, cie?aia,
na/iaeie, ia noai AI-nenoaie i?aai?cio i?ae /an cia/ieo o?ce/ieo
iaaaioaaeaiue.

Cai?iiiiiaaii iaoeiai-iaa?oioiaaiee i?aeo?ae aei aeei?enoaiiy e?ii?ai?
eeneioe, ye i?io?eaeoe/iiai caniao, yeee /eieoue aioeieneaeaioio ?
e?iio?iiio ae?th oa iineaaeth? iani?eyoeeaee aieea aenieeo
eiioeaio?aoe?e na/iaeie a e?ia? nii?oniai?a i?ae /an cia/ieo i’yciaeo
iaaaioaaeaiue.

Io?eiai? aenia?eiaioaeuei? aeai? ?aieiai? aeeiai?ee iieaciee?a, ye?
oa?aeoa?ecothoue ia?aaaaeath/o aeoea?caoe?th aoaeaaiaeiiai, aee?iaiai oa
a?eeiaiai iai?i?a aeey caaacia/aiiy i?ioean?a a?aeiiaeaiiy i?aeaeuothoue
aoaeoeai?noue ea?oaaiiy o?aioaaeueiei i?ioeanii o aeaeao nii?oo, ye?
iia’ycai? ?c ?icaeoeii aeo?eaaeino?.

?aae?caoe?y ?aeiiaiaeaoe?e ai?iaaaeaeaia o i?aeoeeo o?aioaaeueiiai
i?ioeano ca??ii? eiiaiaee Oe?a?ie c eaaei? aoeaoeee (a?a ia na?aaei?
aeenoaioe??) ? no/aniiai i SYMBOL 146 \f «Times New Roman» \s 12 ’
yoeai?noaa, i?i ui na?ae/aoue aeoe ai?iaaaeaeaiiy.

Ai?iaaoe?y ?iaioe ? aeaeea?oaaiiy iniaenoiai aianeo aeena?oaioa a
io?eiaiiy iaoeiaeo ?acoeueoao?a. Iaoa??aee aeena?oaoe?? iia?aeiieai? e
iaaiai?ai? ia III i?aeia?iaei?e eiioa?aioe?? «Sports Science of Young
Scientists, Masters and Ph D Students» (aeiaoaiue 20-21, Oa?oo, 1994),
ia I?aeia?iaei?e eiioa?aioe?? «The Modern Olympic Sports» (o?aaaiue
16-19, Ee?a, 1997), a oaeiae ia can?aeaiiyo eaoaae?e iaaeeei-a?ieia?/ieo
iniia o?ce/ii? eoeueoo?e ? nii?oo IOOAN Oe?a?ie ? can?aeaiiyo
eaai?aoi??? niaoe?ae?ciaaiiai nii?oeaiiai oa?/oaaiiy AeIAe?OAN i?ioyaii
1996 – 1999 ?ie?a.

Aianie aaoi?a iieyaa? o ?ic?iaoe? oai?aoe/iiai i?aea?oioy ? iaoeiaiai
i?aeoiaeo aei ?ica’ycaiiy ieoaiue, ye? iia’ycai? ?c oaiith aeena?oaoe??,
i?aai?caoe??th oa i?iaaaeaiiyi aenia?eiaioaeueieo aeine?aeaeaiue,
io?eiaii? oaeoe/iiai iaoa??aeo, i?iaaaeaii? oai?aoe/iiai aiae?co
io?eiaieo aeaieo, a oaeiae ?ic?iaoe? ia i?aenoaa? iae?eo a?ieia?/ii?
aeoeaiino? na/iaeie ? aeeiai?ee ?? ai?noo a e?ia? i?ae /an iai?oaeaii?
i’yciai? ae?yeueiino? ?aeiiaiaeaoe?e c ei?aeoe?? noaio aioeieneaeaioii?
nenoaie aeey i?aeaeuaiiy iii?o i?aai?cio aei iai?oaeaii? i’yciai?
ae?yeueiino?. Aei ni?eueieo ioae?eaoe?e oa?eoee ?acoeueoaoe aeanieo
aeine?aeaeaiue ? io?eiai? ia ?oi?e i?aenoaa? aeniiaee.

Ioae?eaoe??.

Ca oaiith aeena?oaoe?eii? ?iaioe iioae?eiaaii 10 iaoeiaeo i?aoeue. C ieo
o?noue noaoae iiaeai? o iaoeiaeo aeo?iaeao ca oaoii, ye? caoaa?aeaeai?
AAE Oe?a?ie: o aeo?iae? «Iaoea a ieeiieeneii nii?oa» ? ca??eao iaoeiaeo
i?aoeue, a oaeiae o ca??eao oac i?aeia?iaeieo eiioa?aioe?e ? iaoa??aeao
iaoeiaeo eiioa?aioe?e ani??aio?a.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 180
noi??ieao, neeaaea?oueny c? anooio, /ioe?ueio ?icae?e?a, i?aeoe/ieo
?aeiiaiaeaoe?e, aeniiae?a ? 26 aeiaeaoe?a. O ?iaio? aeei?enoaii 240
e?oa?aoo?ieo aeaea?ae, c ieo 140 a?o/eciyieo oa 100 ?iicaiieo aaoi??a (a
iniiaiiio ?iaioe inoaii?o 10 ?ie?a — 1987–1998). Iaoa??aee
aeine?aeaeaiue ?ethno?iaai? 18 iaethieaie oa 24 oaaeeoeyie.

Iniiai? ?acoeueoaoe aeine?aeaeaiue

1. Ia?oee ?icae?e – “A?ieia?/ia oa?aeoa?enoeea na/iaeie” i?enay/aiee
aiae?co iaoeiai? e?oa?aoo?e, yea noino?oueny ieoaiue a?ieia?/ii? ?ie?
na/iaeie a i?aai?ci? ethaeeie, iniaeeainoae a?eeiaiai iaoaaie?cio,
i?ioean?a aeoea?caoe?? ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) ?
iniaeeainoae aioeieneaeaioiiai caoenoo i?aai?cio ethaeeie i?ae /an
iai?oaeaii? i’yciai? ae?yeueiino?, a oaeiae o ??ci? ia??iaee
a?aeiiaeaiiy. Iniaeeaa oaaaa i?eae?eyeanue ?icaeyaeo ieoaiiy, yea
noino?oueny iaoai?ci?a aioeieneaeaioii? ae?? aeine?aeaeoaaiiai
iaoaaie?oo. Iaeiae o i?iaiae?ciaai?e iaie iaoeia?e e?oa?aoo?? ia
aaeaeinue aeyaeoe /?oei? iiceoe?? aeine?aeiee?a c aeaiiai ieoaiiy. Oae,
?yae aaoi??a (?.A. Aie/aai?nueeee, 1996, Ae.A. Aeyoeia, 1996, I.A.
Eai?y, 1993, A.?. Eoeao, 1993, A.I. Oaaei, 1994, H. H. Draper, 1993, E.
Niki, 1986) a?aeiinyoue na/iaeio aei iecee iecueeiiieaeoey?ieo
aiaei?ic/eiieo aioeieneaeaio?a, ye? i?noyoue acio ? noai?ththoue o
oeaieiao «aooa?io aioeieneaeaioio nenoaio». Iaaaaeai? ??ci? iaoai?cie
aieeao: aeoeaia ia?aoiieaiiy a?eueieo ?aaeeeae?a o aiaeyi?e oac?,
ia?aoeiaeaeaiiy ieeneaiiy Fe2+, a iane?aeie /iai aaeueiothoueny i?ioeane
IIE o aiiiaaiaoao ??cieo oeaiei oaa?ei, ui aeyaey?oueny a cieaeaii?
ooai?aiiy i?iaeoeo?a, ye? ?aaaothoue c o?iaa?a?oo?iaith eeneioith
(iaeiiiaiai ae?aeueaeaa?aeo).

Ii?yae ?c oeei ?niothoue iaoeia? aeai?, ye? na?ae/aoue i?i oa, ui
na/iaeia a eiioeaio?aoe?yo, yea ia aeeeeea? aeaiaoo?aoe?eieo ci?i
a?ee?a, c iaeiiai aieo, ni?ey? «?iceaaeiaiith» a?eeiaeo no?oeoo? c
iaeii/aniei aea?eueiaiiyi aeiaeaoeiai? e?eueeino? SH-a?oi, aea, c ?ioiai
aieo, ni?ey? ?oi?e iiaeaeueo?e iiaeeo?eaoe?? a ae?noeueo?aei? a?oie
(O.N. Eiooiyioe, 1956, A.I. Iaioo?i, 1956). Iaa?yae /e oea iiaea
?icaeyaeaoeny, ye aeya na/iaeiith aioeieneaeaioieo aeanoeainoae, oiio
ui, ii-ia?oa, ae?noeueo?aei? a?oie aeanoaa?e?cothoue a?iiaia?aie
(«no?oeoo?iee i?iieneaeaio»); ii-ae?oaa, iaaeinoaoiy e?euee?noue
a?eueieo SH-a?oi ni?ey? i?enei?aiith i?io?eaiiy i?ioean?a
a?eueii-?aaeeeaeueiiai ieeneaiiy (A?I); ii-o?ao?, ?iaeoeaothoueny
aioeieneaeaioi? oa?iaioe (O.A. Naciiiaa, 1995, TH.A. Iao?ia, 1991, S.B.
Stromme, 1996, K.E. Flaim, 1996).

Ine?eueee AI-nenoaia i?aai?cio ? aeineoue aaaeeeaei ia’?eoii
oe?eani?yiiaaii? oa?iaeieia?/ii? ei?aeoe?? c iaoith i?aeaeuaiiy iii?o
i?aai?cio aei iai?oaeaieo o?ce/ieo iaaaioaaeaiue (A.E. Nioeuenueeee,
1997, G. Karlsson, 1997), oi c’ynoaaiiy oa?aeoa?o o/ano? na/iaeie o
i?ioeanao, ye? iia’ycai? ?c ?aaeoe?yie a?eueii?aaeeeaeueiiai ieeneaiiy
i?ae /an i’yciai? ae?yeueiino? nii?oniai?a, i?aaenoaaey? cia/iee
oai?aoe/iee ? i?aeoe/iee ?ioa?an. Anoaiiaeaiiy oeeo caeiiii??iinoae —
ia’?eoeaia ia?aaeoiiaa aei iaa?oiooaaiiy aeai?o ? canoinoaaiiy cania?a
ei?aeoe?? o?ce/ii? i?aoeacaeaoiino? nii?oniai?a.

2. Ae?oaee ?icae?e — “Iaoiaee oa i?aai?caoe?y aeine?aeaeaiue” —
aena?oeth? i?aai?caoe?th ? iaoiaee aeine?aeaeaiue, ye?
aeei?enoiaoaaeenue aeey ?ica’ycaiiy iinoaaeaieo caaea/.

Oae, aeey ?ica’ycaiiy ia?oi? caaea/? aei aeine?aeaeaiue caeo/aeeny thi?
a?aoie ia na?aaei? aeenoaioe?? a?eii 13…15 ?ie?a, ye? iathoue
nii?oeaiee noaae ia iaioa aeaio ?ie?a ? aeeiioaaee o?aioaaeueio i?ia?aio
aiaa?iaii-aa?iaiiai iai?yio (a?a 8 ?ac 200i c ?ioa?aaeii a?aeii/eieo
2oa. ? c ?ioaineai?noth 80 % a?ae iaeneiaeueii?) i?ioyaii o?ueio aei?a
i?ae?yae. Uiaeiy ?aieii iaouana?oea aecia/aee eiioeaio?aoe?th o e?ia?
na/iaeie, eaeoaoo ? eaoiniieoe ?c ianooiiith ioe?ieith aeyao ?ooiaeo
yeinoae ca ?acoeueoaoaie iaaeaaia?/ieo oanooaaiue — oaeaee?nieo (a?a 30
i c? noa?oo) ? oaeaee?nii-neeiaeo (?acoeueoao o 10-oe ?aciaiio no?eaeo c
i?noey) yeinoae ? oaeaee?nii? aeo?eaaeino? (a?a 300 i).

Aeine?aeaeaiiy iiaeoethth/iai aieeao na/iaeie ia noai AI-nenoaie
ia?aaeaa/aei i?iaaaeaiiy aeine?aeaeaiue ca oiia in vitro. Ia’?eoii
aeine?aeaeaiiy noaea ieacia aai aaiie?cao e?ia? ethaeeie, ye? ?ieoaoaaee
i?ioyaii 10 oa. ?c na/iaeiith a ??cieo eiioeaio?aoe?yo (1,7…17,5
iiieue SYMBOL 215 \f «Symbol» \s 12 * e -1) ca oaiia?aoo?e 370 N. O
eiaei?e na??? aeine?ae?a aoei aeeiiaii a?ae 7 aei 10 aecia/aiue
(caaaeueia e?euee?noue neeaea i?eaeecii 120 i?ia). Aecia/aee
eiioeaio?aoe?th i?iaeoeo?a, ye? ?aaaothoue ?c o?iaa?a?oo?iaith eeneioith
iaoiaeii Noaeueii? ?.Ae. (1977), aeoeai?noue aioeieneaeaioieo oa?iaio?a
— noia?ieneaeaeeniooace (NIAe) ? eaoaeace (Eao) oa ai?no caaaeueieo
SH-a?oi (iaoiaeii aiia?iiao?e/iiai oeo?oaaiiy).

C iaoith aeine?aeaeaiiy aieeao na/iaeie ia i?ioeane ieeniiai
oinoi?eethaaiiy a ?cieueiaaieo i?oioiiae??yo ia/?iee aenia?eiaioaeueieo
oaa?ei aoa aeei?enoaiee iiey?ia?ao?/iee iaoiae (A.I. O?aie,1973).

A?aeiia?aeii aei /aoaa?oi? caaea/? aeine?aeaeaiiy aoei i?iaeiaaeaii a
aeine?aeao in vivo ?c aeei?enoaiiyi aenia?eiaioaeueieo oaa?ei.
Eaai?aoi?i? ieo? aoee ?icae?eai? ia 4 a?oie: eiio?ieueio ? o?e
aeine?aei?, yeei ?iaeee ?i(?eoe?? (i?aeoe??ii) ca 60 oa. ia?aae
ieaaaeueiei iaaaioaaeaiiyi – na/iaeio a aeic? 500ia SYMBOL 215 \f
«Symbol» \s 14 * ea-1 (ui i?eaeecii iiaea a?aeiia?aeaoe ??
eiioeaio?aoe?? a e?ia? i?ney cia/ieo o?ce/ieo iaaaioaaeaiue), e?ii?ao
eeneioo o oa?aiaaoe/i?e aeic? — 50 ia SYMBOL 215 \f «Symbol» \s 14 *
ea-1 ? iaeii/anii e?ii?ao eeneioo ? na/iaeio a oeo aea aeicao, ui e o
iiia?aaei?o a?oiao. Iieacieeii o?ce/ii? i?aoeacaeaoiino?
aenia?eiaioaeueieo oaa?ei neoaeeee ?acoeueoaoe oanoo G.F. Kiplinger
(1967). O aeine?aeaeaii? aoei aeei?enoaii caaaeueiith e?euee?noth 40
oaa?ei.

?ica’ycaiiy i SYMBOL 146 \f «Times New Roman» \s 12 ’ yoi? caaea/?
aeine?aeaeaiiy i?iaaaeaia ca o/anoth aenieieaae?o?eiaaieo nii?oniai?a
(/ieia?e?a) — nooaeaio?a IOOANO a?eii 19–26 ?ie?a, ye? niaoe?ae?coaaeeny
o eaaeiaoeaoe/iiio a?c? ia na?aaei? aeenoaioe?? ? aeeiioaaee 15 ei
i?ia?a ca *NN 160–170 oae SYMBOL 183 \f «Times New Roman» \s 12 · oa-1
(na?aaei?e /an iiaeieaiiy aeenoaioe?? 1 aiae. 15 oa) oa
aaney??a-aeaaeai?no?a, ye? aeeiioaaee 6 oaeeeiio i’yciao ?iaioo
noaiaeneiaeueii? ?ioaineaiino? iiooaei?noth 370 – 400 Ao ia
aaney?nueeiio o?aiaaea??.

Ca aiaeeio aei aeeiiaiiy iaaaioaaeaiue nii?oniaie aeine?aeieo a?oi
i?eeiaee per os eainoeueiaaio e?ii?ao eeneioo aeicith 600 ia
(oa?aiaaoe/ia aeicoaaiiy), a o eiio?ieueieo a?oi — a?aeiia?aeii ieaoeaai
(e?ioiaeue o eainoe?). O e?ia? aei?iaoaaieo o ii/aoeiaiio noai? ia
6-o?e…8-i?e oaeeei? a?aeiiaeaiiy, a oaeiae ia ?aiie ianooiiiai aeiy
aecia/aee eiioeaio?aoe?th caaaeueieo SH-a?oi, a oaeiae ai?no aeayeeo
i?iaeoeo?a noano?aoiiai iaoaaie?cio: eaeoaoo, a?eueieo aee?ieo eeneio
(AAEE), na/iaeie. I?iaiaeeee ?a?no?aoe?th aeayeeo o?c?ieia?/ieo
iieaciee?a: ?iaeaen iai?oae i?iea?aeo (ca ?.I. Aa?anueeei,1984) ?
i?oaeii-a SYMBOL 146 \f «Times New Roman» \s 12 ’ yce? aeanoeaino?
i’yc?a (ca A.I. Oaaei?iaei, 1970). Iaaeaaia?/i? iaoiaee aeine?aeaeaiue
ai?uoaaee ioe?ieo oaeaee?nieo yeinoae ca ?acoeueoaoaie a a?ao ia 60 i ?c
noa?oo ? oaeaee?nii? aeo?eaaeino? — a?a 600i. A?aeiia?aeii aei aeaieo
eaeaiaea?ieo aeeniaina?ieo ianoaaeaiue an? aei?iaoaai? aoee i?aeoe/ii
caei?ia?. Ianoaaeaii caaaeueiith e?euee?noth 90 nii?oniai?a.

Io?eiaiee oeeo?iaee iaoa??ae ?acoeueoao?a i?iaaaeaieo aeine?aeaeaiue
ia?iaeyee iaoiaeaie aa??aoe?eii? noaoenoeee ca aeiiiiiaith noaiaea?oieo
eiii’thoa?ieo i?ia?ai ia ia?niiaeueiiio eiii’thoa?? IBM PC AT-486 DX.

3. O o?aoueiio ?icae?e? — “Ei?aeoe?y o?ce/ii? i?aoeacaeaoiino?
nii?oniai?a c o?aooaaiiyi iiaeoethth/iai aieeao na/iaeie ia noai
aioeieneaeaioii? nenoaie i?aai?cio” iiaeai? ?acoeueoaoe aeanieo
aeine?aeaeaiue.

Ca’ycie ?aieiai? aeeiai?ee eiioeaio?aoe?? na/iaeie c eiioeaio?aoe??th
eaeoaoo, eaoiiiaeo niieoe o e?ia? ? iieacieeaie o?ce/ii?
i?aoeacaeaoiino? nii?oniai?a i?ae /an iai?oaeaii? i’yciai? ae?yeueiino?

?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy na?ae/aoue i?i oa, ui i?ae
aecia/aieie iieacieeaie ?nio? aca?iica’ycie, yeee iieyaa? o oiio, ui c
iiaeeaeaiiyi noaio aoiie i?ney cia/ieo o?aioaaeueieo iaaaioaaeaiue o
nii?oniai?a aecia/a?oueny niaaeei?ii?noue o ia?aaaaeaeueiiio
aeei?enoaii? a i?aai?ci? aia?aaoe/ieo noano?ao?a, ye? caaacia/othoue
i?io?eaiiy a?aeiiaethaaeueieo i?ioean?a. Oaeee «iaoaaie?/iee oii»
oa?aeoa?eco? noeeuei?noue nii?oniai?a aei aeeiiaiiy o?ce/ieo ai?aa o???
aai ?ioi? ni?yiiaaiino?. Oa?aeoa?iei aeey noaio iiaeeaeaiiy aoiie i?ney
o?ueio iine?aeiaieo cia/ieo o?aioaaeueieo iaaaioaaeaiue ? ??cea
ca?eueoaiiy eiioeaio?aoe?? na/iaeie a e?ia? (a?ae 3,0  SYMBOL 177 \f
«Symbol» \s 14 ± 0,16 iiieue SYMBOL 215 \f «Symbol» \s 14 * e-1 aei 6,0 
SYMBOL 177 \f «Symbol» \s 14 ± 0,27 iiieue SYMBOL 215 \f «Symbol» \s
14 * e-1 P < 0,0001) c iaeii/aniei cieaeaiiyi ooee?caoe?? aoaeaaiae?a ? aee??a o a?aeiiaethaaeueiiio ia??iae? (ca iieacieeaie eaeoaoo ? eaoiniieoe, ye? aeinoia??ii ciaioeeeny ieae/a aeo?aeiiai ??aiy, P < 0,05). Oaeee noai noi?iaiaeaeoaaany oaeiae iia??oaiiyi oaeaee?nieo yeinoae ? oaeaee?nii? aeo?eaaeino? (ca ?acoeueoaoaie a?ao ia 30i ? 300i aei /aoaa?oiai aeiy i?e?ioeeeeo, P < 0,05). Oa?aeoa?iith iciaeith aeey iieiaeeo nii?oniai?a ? a?eueo iecueea eiioeaio?aoe?y na/iaeie a e?ia?, yea ciaoiaeeoueny a iaaeao 2,5...3,6 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1. Oeae oaeo iaoiiaeaiee oei, ui a i?aee?oeiaiio a?oe? aiaaie?/i? i?ioeane ia?aaaaeathoue iaae eaoaaie?/ieie, ine?eueee ai?iieeneioe aeei?enoiaothoueny a?eueoith i??ith aeey neioaco a?eea e iaioith – ye aia?aaoe/iee noano?ao. Aeine?aeaeaiiy iiaeoethth/iai aieeao na/iaeie ia noai ie?aieo eaiie aioeieneaeaioii? nenoaie i?aai?cio ethaeeie Aiae?c ?acoeueoao?a a?aeiia?aeiiai aoaio aeine?aeaeaiue iieacaa, ui aeine?aeaeoaaiee iaoaaie?o aeyaey? ye aioeieneaeaioio, oae ? i?iieneaeaioio ae?th. I?e/iio oaeee aieea caeaaeeoue a?ae eiai eiioeaio?aoe??. Oae, aeai? aecia/aiiy caaaeueii? aioeieneaeaioii? aeoeaiino? e?ia? ethaeeie a i?enooiino? na/iaeie na?ae/aoue i?i ?? aioeieneaeaioio aeoeai?noue o aenieeo o?c?ieia?/ieo eiioeaio?aoe?yo. Oaeee oaeo aeyaey?oueny o aeinoia??iiio cieaeaii? eiioeaio?aoe?? i?iaeoeo?a, ye? ?aaaothoue ?c OAE ca oiia ?i?oe?aoe?? i?ioean?a IIE 0,1 iiieue Fe2+ (a?ae 1,00 SYMBOL 177 \f "Symbol" \s 12 ± 0,03 aei 0,72 SYMBOL 177 \f "Symbol" \s 12 ± 0,03 ieiieue SYMBOL 215 \f "Symbol" \s 14 * e-1, ?< 0,001) o aeiaaeeo, eiee eiioeaio?aoe?y na/iaeie neeaaeaea 15 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1. Oa?aeoa?iei ? oa, ui i?e a?aenooiino? oaei? ?i?oe?aoe?? Fe2+ noaoenoe/ii aeinoia??ieo ci?i aecia/aieo iieaciee?a aeyaeaii ia aoei (iae. 1). Ioaea, iiaeia aaaaeaoe, ui aioeieneaeaioiee aoaeo aenieeo eiioeaio?aoe?e na/iaeie aoa iaoiiaeaiee i?eaiiaeaiiyi ?i?oe?aoe?? eao?iiaie Fe2+ ?aaeoe?e a?eueii-?aaeeeaeueiiai ieeneaiiy, /iai ia niinoa??aaeiny ca oiia a?aenooiino? Fe2+. – i?ney 10-oe oaeeeiii? ?ieoaaoe??; – o i?enooiino? 15iiieue SYMBOL 215 \f "Symbol" \s 10 * e-1 na/iaeie. Aenia?eiaioaeuei? aeai? aieeao na/iaeie ia noai o?ie-aeenoeueo?aeii? eaiee AI-nenoaie na?ae/aoue i?i cia/ia i?enei?aiiy ieeneaiiy SH-a?oi e?ia? ethaeeie o i?enooiino? na/iaeie, eiioeaio?aoe?y yei? neeaaeaea 10,0...16,0 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1 (?< 0,05). Oaeei /eiii, ia a?aei?io a?ae ?acoeueoao?a iiia?aaeiueiai aeine?aeaeaiiy, na/iaeia o aenieeo o?c?ieia?/ieo eiioeaio?aoe?yo aeyaeyea i?iieneaeaioio aeanoea?noue noiniaii aeine?aeaeoaaii? eaiee aioeieneaeaioii? nenoaie e?ia? ethaeeie. Caneoaiao? ia oaaao oa, ui ?ieoaaoe?y i?ia o i?enooiino? ?? eiioeaio?aoe?e, ye? a?aeiia?aeathoue ii?i? niieith (3,3...6…6,6 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1), ia aeeeeeaea aeinoia??iiai cieaeaiiy eiioeaio?aoe?? o?ieiaeo a?oi o aaiie?cao? e?ia? (oaae. 1). Oaaeeoey 1 Aieea 10-oe oaeeeiii? ?ieoaaoe?? na/iaeie o ??cieo eiioeaio?aoe?yo ca t 37i N ia caaaeueio eiioeaio?aoe?th SH-a?oi o ieaci? e?ia? ethaeeie (n=7) Eiioeaio?aoe?y na/iaeie, yeo aaiaeeee (iiieue SYMBOL 215 \f "Symbol" \s 11 * e–1) Eiioeaio?aoe?y SH-a?oi (ieiieue SYMBOL 215 \f "Symbol" \s 11 * e–1) Eiio?ieue 95,0 SYMBOL 177 \f "Symbol" \s 11 ± 0,5 3,3 85,5 SYMBOL 177 \f "Symbol" \s 11 ± 0,4 6,6 88,4 SYMBOL 177 \f "Symbol" \s 11 ± 0,6 10,0 78,9 SYMBOL 177 \f "Symbol" \s 11 ± 0,3 * 13,0 67,5 SYMBOL 177 \f "Symbol" \s 11 ± 0,5 * 16,0 40,9 SYMBOL 177 \f "Symbol" \s 11 ± 0,6 * I?ei?oea: * — iicia/ai? ?acoeueoaoe, ??aaiue aeinoia??iino? yeeo ?<0,05. Anoaiiaeaii oaeiae, ui na/iaeia a eiioeaio?aoe?yo aei 10,0 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1 aeinoia??ii ia aieeaa? ia aeoeai?noue oaeeo aioeieneaeaioieo oa?iaio?a, ye NIAe ? Eao (? > 0,05), oiae? ye ??
aenie? eiioeaio?aoe?? ni?eythoue ciaioaiith ?o aeoeaiino? — NIAe aei
13,8 SYMBOL 177 \f «EuroRoman» \s 12 ± 0,56 AA·ie-1 i?e aeo?aei?e 18,2
SYMBOL 177 \f «EuroRoman» \s 12 ± 0,15 AA·ie-1, a aeoeaiino? Eao — aei
10,10 SYMBOL 177 \f «EuroRoman» \s 12 ± 1,2 Ieao·e-1 i?e aeo?aei?e 12,6
SYMBOL 177 \f «EuroRoman» \s 12 ± 0,01 Ieao·e-1, ?< 0,005 (iae. 2). Iae. 2 Aieea ??cieo eiioeaio?aoe?e na/iaeie ia aeoeai?noue aioeieneaeaioieo oa?iaio?a o e?ia? ethaeeie (iiaeaii a % a?aeiinii ii/aoeiaiai ??aiy) ii in? aanoeen – eiioeaio?aoe?y na/iaeie, yeo aaiaeeee (n=7) A – aeoeai?noue noia?ieneaeaeeniooace; A – aeoeai?noue eaoaeace. Oaeei /eiii, ?acoeueoaoaie cacia/aii? na??? aeine?aeaeaiue anoaiiaeai? iniaeeaino? aieeao na/iaeie ia noai aeine?aeaeoaaieo eaiie AI-nenoaie. Ca?aeii c io?eiaieie ?acoeueoaoaie na/iaeio o o?c?ieia?/ieo eiioeaio?aoe?yo, ye? a?aeiia?aeathoue ?? cia/aiiyi niieith (3,3...6,6 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1), ne?ae aaaaeaoe iaeo?aeueiith ?a/iaeiith. I?aeaeuaiiy eiioeaio?aoe?? oeueiai iaoaaie?oo a e?ia?, ui ye a?aeiii, oa?aeoa?eco? iaaaeaeaaoio ?aaeoe?th i?aai?cio ia cia/i? o?ce/i? iaaaioaaeaiiy, cae?enith? iiaeoethth/ee aieea – aioeieneaeaioiee, aai ae i?iieneaeaioiee. Aieea na/iaeie ia i?ioeane aia?aiooai?aiiy ? o?ce/io i?aoeacaeaoi?noue aenia?eiaioaeueieo oaa?ei oa aeioe?euei?noue canoinoaaiiy e?ii?ai? eeneioe Aeyaeaii iani?eyoeeaee aieea na/iaeie o eiioeaio?aoe?? 1,7 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1 ia i?io?eaiiy i?ioean?a ieeniiai oinoi?eethaaiiy a ?cieueiaaieo i?oioiiae??yo ia/?iee aenia?eiaioaeueieo oaa?ei, yeee aeyaeany o ?iceaaeiaii? aeeoaiiy oa oinoi?eethaaiiy, i?i ui na?ae/eoue cieaeaiiy eiao?oe??ioa AAeO/I (ia 33,6%, P <0,05), yeee oa?aeoa?eco? nooi?iue ii?aeiaiiy aeine?aeaeoaaieo i?ioean?a. Aenie? eiioeaio?aoe?? oe??? ?a/iaeie oe?eeii i?eai?/oaaee ooieoe?th i?oioiiae??e. Anoaiiaeaiee aoaeo aieeao na/iaeie aaaaea?oueny iani?eyoeeaei, ine?eueee a?i ii?ooo? i?ioean ii?iaeueiiai i?io?eaiiy i?ioean?a aia?aicaaacia/aiiy i'yciai? ae?yeueiino?. Caneoaiaothoue ia iniaeeao oaaao aeai? i?i oa, ui aeeiiaiiy ieaaaeueieo caaaeaiue oaa?eiaie o oano? G.F. Kiplinger (1967) aoei cia/ii cao?oaeiaia ca oiia i?aeaeuaii? eiioeaio?aoe?? na/iaeie a e?ia?, i?i ui na?ae/eoue aeinoia??ia cieaeaiiy i?aoeacaeaoiino? (P < 0,05) oaa?ei ii??aiyii c eiio?ieueieie caieeaaie. Oae, yeui na?aaei?e /an i?iieeao oaa?eiaie a?ae??ce?a o 16...20 ni?iaao o ae?oaiio oanooaaii? neeaei aeey eiio?ieueii? a?oie 8,48 SYMBOL 177 \f "Symbol" \s 12 ± 0,53n ii??aiyii c a?aeiia?aeiei iieacieeii ia?oiai oanooaaiiy 7,34 SYMBOL 177 \f "Symbol" \s 12 ± 0,45n, oi o aeine?aei?e a?oi? (c ai?noii aeniei? eiioeaio?aoe?? na/iaeie a e?ia?) aiii c?inei c 7,84 SYMBOL 177 \f "Symbol" \s 12 ± 0,58n aei 11,39 SYMBOL 177 \f "Symbol" \s 12 ± 0,62n (P < 0,05). I?i a?eueo oaeaeeee ?icaeoie noiieaiiy i?ae aieeaii na/iaeie na?ae/eoue oaeiae a?eueoee eoo iaoeeo e?i?? ?aa?an??, yeee a?aeia?aaea? caeaaei?noue /ano i?iieeao ieoaie a?ae??ce?a a?ae e?eueeino? ni?ia. Oaeei /eiii, ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aieeao na/iaeie a ?? ??cieo eiioeaio?aoe?yo ye ia noai ie?aieo eaiie AI-nenoaie, oae ? ia i?ioeane aia?aiooai?aiiy ? o?ce/io i?aoeacaeaoi?noue ocaiaeaeothoueny c no/anieie oyaeaiiyie i?i a?ieia?/io aeoeai?noue na/iaeie a i?aai?ci? ? ?ice?eaathoue iaoai?cie ?? iiaeeeai? o/ano? (o aenieeo eiioeaio?aoe?yo) o i?ioeanao ?icaeoeo noiieaiiy i?ae /an iai?oaeaii? i'yciai? ae?yeueiino?. Ine?eueee iaeiei ?c iaoai?ci?a iani?eyoeeaiai aieeao na/iaeie o aenie?e eiioeaio?aoe?? ia noai AI-nenoaie e?ia? ? o?ce/ii? i?aoeacaeaoiino? ? ?? ni?iiiaei?noue i?enei?thaaoe ieeneaiiy SH-a?oi, ye? aaaeeea?, ye a?aeiii, ia eeoa aeey ii?iaeueiiai i?io?eaiiy i?ioean?a ieeniiai oinoi?eethaaiiy, aea ? aeey ae?eie?co (A.A. Nieieianueeee, 1988), oi ia?aaeaa/aeiny, ui canoinoaaiiy o?ieiaeo i?aia?ao?a ?, cie?aia, e?ii?ai? eeneioe (EE) caiia?aaoeia ?icaeoeo aeyaeaieo iani?eyoeeaeo iane?aee?a i?aeaeuaiiy eiioeaio?aoe?? na/iaeie o e?ia?. C iaeyaeo ia iiaeai? aeua ?acoeueoaoe i?i oa, ui cia/ia i?aeaeuaiiy eiioeaio?aoe?? na/iaeie a?aeaoaa?oueny o ii?aeiaii? c? cieaeaiiyi aeei?enoaiiy aoaeaaiae?a ? aee??a ye noano?ao?a aeey aia?aicaaacia/aiiy, oi noeioeyoe?y e?iie?co ? iaeiei ?c cania?a iiia?aaeaeaiiy iaaaaeaiiai iineeaiiai ooai?aiiy oeueiai iaoaaie?oo i?ae /an iai?oaeaii? i'yciai? ae?yeueiino?. O ca'yceo c oei, ui EE ia? oaeiae ? e?iio?iiio ae?th, oeae i?aia?ao aoa ia?aiee aeey cae?eniaiiy ei?aeoe?? o?ce/ii? i?aoeacaeaoiino? o aeaeao nii?oo, ye? iio?aaothoue aeyao aeo?eaaeino?. Ia iniaeeao oaaao caneoaiaothoue aeai?, ye? na?ae/aoue i?i oa, ui iiia?aaei? aaaaeaiiy eeii?ai? eeneioe oaa?eiai noaoenoe/ii aeinoia??ii noaei ia ia?aoeiae? cia/iiio ciaioaiith o?ce/ii? i?aoeacaeaoiino? ca ?acoeueoaoaie oanoo G.F. Kiplinger (1967). Aieea e?ii?ai? eeneioe ia aeaye? iaoaaie?/i? oa o?c?ieia?/i? iieacieee nii?oniai?a i?ae /an iai?oaeaii? i'yciai? ae?yeueiino? Aeyaeaiee iiaeoethth/ee aieea aenieeo eiioeaio?aoe?e na/iaeie ia noai AI-nenoaie e?ia?, a oaeiae iiceoeaiee aieea canoinoaaiiy EE ia o?ce/io i?aoeacaeaoi?noue aenia?eiaioaeueieo oaa?ei noaee ia?aaeoiiaith aeey i?iaeiaaeaiiy aeine?aeaeaiue ca o/anoth nii?oniai?a c aea/aiiy aoaeo?a aaeeaaiiy oeueiai i?aia?aoo. I?iaaaeaieie aeine?aeaeaiiyie anoaiiaeaii, ui iiia?aaei? (ca 60oa.) aaeeaaiiy EE ye aenieieaae?o?eiaaieie aaneoaaeueieeaie-aeaaeai?noaie, oae ? eaaeiaoeaoaie aeicith 600 ia ni?ey? oo?eiaiith SH-a?oi o e?ia? o nii?oniai?a aeine?aeieo a?oi ia ii/aoeiaiio ??ai? (iaaeinoia??i? ci?ie), ia a?aei?io a?ae aeinoia??iiai cieaeaiiy (?< 0,05) o eiio?ieuei?e a?oi?, i?ney aeeiiaiiy nii?oniaiaie iaaaioaaeaiue ye aa?iaii-aiaa?iaiiai, oae ? aa?iaiiai oa?aeoa?o, ui aa?oi ?icaeyaeaoe ye iiceoeaiee aieea oeueiai i?aia?aoo ia noai o?ie-aeenoeueo?aeii? eaiee AI-nenoaie (iae. 3). Iieaciee Aa?iaii-aiaa?iaia iaaaioaaeaiiy (aaneoaaeueieee-aeaaeai?noe) Aa?iaia iaaaioaaeaiiy (a?aoie ia na?aaei? aeenoaioe??) Eiio?ieueia a?oia (c ieaoeaai) Aeine?aeia a?oia (c eeii?aith eeneioith) Eiio?ieueia a?oia (c ieaoeaai) Aeine?aeia a?oia (c eeii?aith eeneioith) Eiioeaio?aoe?y caaaeueieo SH-a?oi o aaiie?cao? e?ia? Ai?no eaeoaoo a e?ia? Ai?no AAEE a e?ia? Iieaciee i?oaeii-a’yceeo yeinoae ia?aaeiuei? a?oie i’yc?a noaaia Iae. 3 Aieea aaeeaaiiy (per os) e?ii?ai? eeneioe aeicith 600ie aaneoaaeueieeaie-aeaaeai?noaie ca aiaeeio aei 6-oe oaeeeiiiai o?ce/iiai iaaaioaaeaiiy ia aaneoaaeueiiio o?aiaaea?? (iiooaei?noue 370-400 Ao) oa eaaeiaoeaoaie aei i?ia?ao aeenoaioe?? 15 ei oa i?ney iueiai ia aeaye? a?io?i?/i? oa o?c?ieia?/i? iieacieee (n=7) aea: – oanooaaiiy ia 6-?e – 8-?e oaeeei? a?aeiiaeaiiy; – oanooaaiiy ianooiiiai ?aieo i?ney iaaaioaaeaiiy. Canoinoaaiiy EE oaeiae ni?ey? iaio?e "iai?oaeaiino?" aiaa?iaieo iaoai?ci?a aia?aicaaacia/aiiy, ui aeyaeeiny a iaioiio iaeiie/aii? eaeoaoo a e?ia? ii??aiyii c aei?iaoaaieie eiio?ieueieo a?oi. Oae, o aaneoaaeueiee?a-aeaaeai?no?a ii/aoeiaee ??aaiue eaeoaoo a e?ia? aei?iaoaaieo eiio?ieueii? ? aeine?aeii? a?oi neeaa a?aeiia?aeii 1,51 SYMBOL 177 \f "Symbol" \s 12 ± 0,14 ? 1,84 SYMBOL 177 \f "Symbol" \s 12 ± 0,11 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1. I?ney 6-oe oaeeeiiiai iaaaioaaeaiiy noaiaeneiaeueiiai oa?aeoa?o oeae iieaciee c??n a?aeiia?aeii aei 25,00 SYMBOL 177 \f "Symbol" \s 12 ± 0,34 ? 18, 3 SYMBOL 177 \f "Symbol" \s 12 ± 1,08 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1(? < 0,0001). Aaaeeeai a?aecia/eoe, ui aeacaiee aoaeo i?ioiaeea ia oii? noeioethth/iai aieeao EE ia e?iie?c, ui aeyaeeiny a a?eueoiio i?aeaeuaii? a e?ia? nii?oniai?a aeine?aeieo a?oi eiioeaio?aoe?? AAEE. Oae, yeui a aeine?aeieo a?oiao aaneoaaeueiee?a ? a?aoi?a ii/aoeiaee ??aaiue AAEE neeaa 0,56 SYMBOL 177 \f "Symbol" \s 12 ± 0,08 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1 ? 0,60 SYMBOL 177 \f "Symbol" \s 12 ± 0,03 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1, oi i?ney i'yciai? ?iaioe a?i c??n a?aeiia?aeii aei 0,79 SYMBOL 177 \f "Symbol" \s 12 ± 0,07 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1(P < 0,05) ? 0,95 SYMBOL 177 \f "Symbol" \s 12 ± 0,03 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1(P < 0,001). O eiio?ieueieo aea a?oiao aei?iaoaaieo ci?ia aeine?aeaeoaaiiai iieacieea aeyaeeany noaoenoe/ii iaaeinoia??iith. Canoinoaaiiy e?ii?ai? eeneioe ? noiooi? oeueiio ca?eueoaiiy eiioeaio?aoe?? AAEE o e?ia? i?eioneaei aeya caoeniiai aoaeoo inoaii?o noiniaii aeei?enoaiiy ai?iieeneio ye aia?aaoe/ieo noano?ao?a, ui ni?eyei a iaioiio iaeiie/aiith na/iaeie o e?ia?. Iaeiae o aeeiiaiiio iaie aeine?aeaeaii? ia aenieieaae?o?eiaaieo nii?oniaiao aenoiooa i?eiouaiiy caeeoeeiny iaaeiaaaeaiei, ine?eueee eiioeaio?aoe?y na/iaeie a e?ia? aei?iaoaaieo ye aeine?aeii?, oae ? eiio?ieueii? a?oi aei ? i?ney o?ce/iiai iaaaioaaeaiiy a??ia?aeii ia ci?ithaaeany ? ia ia?aaeuoaaea o?c?ieia?/ii? ii?ie (iae. 3). Oaeee ?acoeueoao ne?ae aaaaeaoe caeiiii??iei o aeiaaeeo, eiee aeeiioaaia i'yciaa ?iaioa a?aeiia?aea? ooieoe?iiaeueiei iiaeeeainoyi nii?oniai?a, a iniiaieie aeaea?aeaie aia?aicaaacia/aiiy neoaeaoue aoaeaaiaee ? e?i?aee, aeei?enoaiiy yeeo ia e?i?oiaaia, ui ie e niinoa??aaee i?ae /an o/ano? o aeine?aeaeaii? aenieieaae?o?eiaaieo nii?oniai?a. I?ioa aiae?c ie?aieo iaoeo niinoa?aaeaiue, a oaeiae aeaieo, ye? iaaaaeai? o ?iaio? A.E. Nioeuenueeiai (1997), na?ae/eoue ia ei?enoue iiaeeeaino? ii?iae?caoe?? ??aiy na/iaeie ca oiia iai?oaeaii? i SYMBOL 146 \f "Times New Roman" \s 12 ’ yciai? ae?yeueiino? ca aeiiiiiaith o?ieiaeo niieoe. I?i ni?eyoeeaee aieea e?ii?ai? eeneioe ia noai ii??ii-?ooiaiai aia?aoo i?ae /an i?ieiiaiaaieo o?ce/ieo iaaaioaaeaiue na?ae/aoue ?acoeueoaoe aecia/aiiy i?oaeii-a SYMBOL 146 \f "Times New Roman" \s 12 ’ yceeo aeanoeainoae i'yc?a ia?aaeiuei? a?oie noaaia a?aoi?a ia na?aaei? aeenoaioe??. Oae, yeui a eiio?ieuei?e a?oi? nii?oniai?a ii/aoeiaee iieaciee a'yceino? ?icneaaeaiiai i'yca (nooi?iue caaanaiiy naeniioaee? — a?aeiioaiiy aiie?ooaee ia?oiai eieeaaiiy aei aiie?ooaee ae?oaiai), o na?aaeiueiio aei??aithaaa 5,41 SYMBOL 177 \f "Symbol" \s 12 ± 0,44 oi.iae., a i?ney a?ao – 5,56 SYMBOL 177 \f "Symbol" \s 12 ± 0,21 oi.iae., oi o aeine?aei?e a?oi? aei?iaoaaieo oeae iieaciee a??ia?aeii ca?eueoeany (a?aeiia?aeii 5,20 SYMBOL 177 \f "Symbol" \s 12 ± 0,45 oi.iae., 6,49 SYMBOL 177 \f "Symbol" \s 12 ± 0,05 oi.iae., ? < 0,05), ui na?ae/eoue i?i ieae/ee nooi?iue ?icaeoeo iai?oaeaiiy i'yc?a ia?aaeiuei? a?oie noaaia o nii?oniai?a aeine?aeii? a?oie i?ney iiaeieaiiy ieie 15-oe e?eiiao?iai? aeenoaioe?? (iae. 3). Aaaeeeaei aoaeoii ia?i?aeueiiai aaeeaaiiy EE ia?aae i?ieiiaiaaiei o?ce/iei iaaaioaaeaiiyi aa?iaii? ni?yiiaaiino? ? a?eueo oaeaeea i?io?eaiiy a?aeiiaethaaeueieo i?ioean?a, ui aeyaey?oueny, cie?aia, o a?eueo aoaeoeaiiio a?aeiiaeaii? iieacieea oaeaee?nieo iiaeeeainoae. Oae, ?acoeueoao c a?ao ia 60i o aeine?aei?e a?oi? iia??oeany a na?aaeiueiio ia 0,23 SYMBOL 177 \f "Symbol" \s 12 ± 0,05 n, a a eiio?ieuei?e — ia 0,47 SYMBOL 177 \f "Symbol" \s 12 ± 0,06n (? < 0,05) (iae. 4). 4. *aoaa?oee ?icae?e - “Iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiue”. Ine?eueee i?aai?ci ethaeeie - neeaaeia niii?aaoethth/a nenoaia, oi aa?o/e aei oaaae aeyaeai? aioeieneaeaioi? aeanoeaino? na/iaeie, i?i ye? oaeiae na?ae/aoue ?.A. Aie/aai?nueeee (1996), Ae.A. Aeyoeia (1996), I.A. Eai?y (1993), A.?.Eoeao (1993), A.I.Oaaei (1994), H. H. Draper (1993), E. Niki (1986), oi ca?eueoaiiy ?? eiioeaio?aoe?? a e?ia? i?ney cia/ieo o?ce/ieo iaaaioaaeaiue aeiionoeii ?icoe?ithaaoe ye aeya caoenieo ooieoe?e i?aai?cio. A?aeiii, ui a aeeaiio i?aai?ci? cae?ci ciaoiaeeoueny a iia SYMBOL 146 \f "Times New Roman" \s 12 ’ ycaiiio noai? (c a?eeaie e ai?iieeneioaie). I?ioa i?ae /an cia/ieo i'yciaeo iaaaioaaeaiue oeae ca'ycie oei/aniai iiaea ii?oooaaoeny aiane?aeie aaiie?co a?eo?ioeeo?a, aeenioe?aoe?? cae?ciai?nieo a?ee?a i?e ci?i? pI ( E. R. Eicner, 1986, J. M. Metzger, 1992). O oeueiio aeiaaeeo aeieea? iiaeeea?noue aca?iiae?? na/iaeie c Fe2+, ui i?eai?/o? ae?th cae?ca ye aieiaiiai noeioeyoi?a ia?aieeneaiiy. Iaeiae iaa?yae /e oea iiaeia aaaaeaoe, ui a nenoai? aioeieneaeaioiiai caoenoo oeae iaoai?ci ? i?ia?aeiei. Iae. 4. Aieea aaeeaaiiy (per os) e?ii?ai? eeneioe aeicith 600 ia eaaeiaoeaoaie ca aiaeeio aei 15-oe e?eiiao?iaiai i?ia?ao ia ?acoeueoao o a?c? ia 60i (n) (n=7), aea A – eiio?ieueia a?oia, A – aeine?aeia a?oia; – oanooaaiiy ianooiiiai ?aieo i?ney iaaaioaaeaiiy. O aaeoc? o?c?ieia?? oa a?io?i?? i'yciai? ae?yeueiino? ooaa?aeeeany aeoiea i?i oa, ui ??cea ca?eueoaiiy eiioeaio?aoe?? na/iaeie a e?ia? a?aeaoaa?oueny aiane?aeie cia/ii? iai?oae aaeaioaoe?eieo iaoai?ci?a ? ? iieacieeii aeoea?caoe?? eaoaaie?/ieo i?ioean?a. Ia aeiaeaoie aaaeeeai oaeiae caoaaaeeoe, ui ca ?acoeueoaoaie aenia?eiaioaeueieo aeaieo i?aeaeuaiiy eiioeaio?aoe?? na/iaeie a e?ia? noi?iaiaeaeo?oueny cieaeaiiyi ooee?caoe?? aoaeaaiae?a ? aee??a ye noano?ao?a aeey aia?aicaaacia/aiiy i?ioean?a a?aeiiaeaiiy, ui ne?ae aaaaeaoe ae?ae iani?eyoeeaei aeey i?aai?cio nii?oniai?a. O ca'yceo c oeei ia iniaeeao oaaao caneoaiaothoue aeai?, ye? na?ae/aoue i?i i?iieneaeaioiee aieea na/iaeie a ?? aenieeo eiioeaio?aoe?yo noiniaii o?ie-ae?noeueo?aeii? eaiee AI-nenoaie, ine?eueee ?? noai a?ae?a?a? aaaeeeao ?ieue a aeoeaiino? i?ia?aeieo oa?iaioaoeaieo nenoai aia?icaaacia/aiiy (I.A. Ao?eaeiaa, 1982, O.O. ?aaiaiei, 1982, N.M. Alessio, 1988, D.D. Hackley, 1995, P. M. Jareman,1996). Ia aeoieo I.A. Eaae?iie (1976) ? Ae.I. Oa?anueyioe (1976) eiioeaio?aoe?y SH-a?oi a e?ia? ? iieacieeii ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio nii?oniai?a ia aeeiiaia iaaaioaaeaiiy. Oaeiae oa?aeoa?ia oa, ui na/iaeia a eiioeaio?aoe?yo aeueo ca 10 iiieue SYMBOL 215 \f "Symbol" \s 14 * e-1 cieaeo? aeoeai?noue aioeieneaeaioieo oa?iaio?a (NIAe ? Eao). Oaeee aieea iiaeia iiynieoe, c iaeiiai aieo, eiiieaeniooai?thth/eie aeanoeainoyie na/iaeie ?, cie?aia, ?? aca?iiae??th c i?aeaeth ? oeeieii, ye? aoiaeyoue aei aeoeaiiai oeaio?o NIAe. Oe?eeii ?aaeueii, ui ooai?aiiy oaeiai eiiieaeno iiaea noaoe i?e/eiith cieaeaiiy aeoeaiino? aiceia. C ?ioiai ae aieo, na/iaeia aieeaa? ia no?oeoo?o a?eeiaeo iieaeoe, ye? ooai?ththoue oa?iaio. ?acii c oeei na/iaeia aenooia? a ?ie? iaeiieo?aioiiai ?ia?a?oi?a. Aeoiaey/e c aeuaaeeeaaeaiiai, iiaeia c?iaeoe aeniiaie, ui io?eiai? iaie ?acoeueoaoe aeine?aeaeaiue aeayeith i??ith ?ice?eaathoue iaoai?cie iiaeeeai? o/ano? oeueiai iaoaaie?oo o i?ioeanao noiieaiiy. O oeueiio aeiaaeeo ia i?aenoaa? io?eiaieo aeaieo iiooe oeyo?a caiia?aaiiy iaaaeaeaaoi?e ?aaeoe?? i?aai?cio i?ae /an iai?oaeaii? i'yciai? ae?yeueiino?, yea ae?aaea?oueny o cia/iiio ca?eueoaii? eiioeaio?aoe?? na/iaeie a e?ia?, ne?ae aaaaeaoe iaoeiai iaa?oioiaaiei i?aeoiaeii aei aeai?o cania?a oa?iaeieia?/ii? ei?aeoe?? c iaoith i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino? nii?oniai?a, ye? aeeiiothoue o?ce/i? ai?aae, ni?yiiaai? ia ?icaeoie aeo?eaaeino?. Iaeiei ?c niinia?a ei?aeoe?? iiaeoethth/iai aieeao na/iaeie ia noai AI-nenoaie ? iiia?aaei? (ca 60...90oa) aaeeaaiiy e?ii?ai? eeneioe o ia??iae aeeiiaiiy "oaea?ieo i?e?ioeeee?a". A aenia?eiaioaeuei?e /anoei? aeine?aeaeaiue ie niinoa??aaee caoenio ae?th oeueiai i?aia?aoo noiniaii aeoaea aaaeeeaeo o ooieoe?iiaeueiiio a?aeiioaii? SH-a?oi a?ee?a ? oa?iaio?a, ye?, ye a?aeiii, a ia?oo /a?ao i?aeaeathoueny ieeneaiith i?ae /an no?aniaeo aieea?a ia i?aai?ci ethaeeie (P.M. Jareman, 1996, R.J. Maxwells, 1996). O oeueiio aeiaaeeo EE aeeiio? ?ieue aeiii?a oeieiaeo a?oi - ca?eueoo? ?oi?e caaaeueiee ioe, ui, o naith /a?ao, caiia?aa? ieeneaiith aiaeiaaiieo SH-a?oi a?ee?a ? oa?iaio?a i?ae /an iai?oaeaii? i'yciai? ae?yeueiino?. Iiceoeaiei aa?oi aaaaeaoe oaeiae noeioethth/ee aieea EE ia e?i?aeiee iai?i, ine?eueee ca oiia iai?oaeaii? i SYMBOL 146 \f "Times New Roman" \s 12 ’ yciai? ae?yeueiino?, i?ae /an yeeo caiane i'yciaiai ae?eiaaio ? iaeiei ?c aieiaieo /eiiee?a, ye? iaiaaeothoue o?ce/io i?aoeacaeaoi?noue, a?eueo aoaeoeaia aeei?enoaiiy ye aia?aaoe/iiai aeaea?aea aee??a aeyaey? aeiiii?coth/ee aoaeo noiniaii caian?a ae?eiaaio (M.S. El-Saed, 1995, J.U. Hill, 1996, J.O. Hollizy, 1996, S.M. Phillips, 1997, A.J. Ratty, 1995). Oea noai?th? a?eueo aea?aei? oiiae aeey caa??aaiiy aeniei? niaoe?aeueii? i?aoeacaeaoiino? ? a?aeaeaeaiiy i?ioean?a noiieaiiy i?ae /an cia/ieo ? o?eaaeeo i'yciaeo iaaaioaaeaiue. Oa?aeoa?ii, ui canoinoaaiiy e?ii?ai? eeneioe nii?oniaiaie i?ae /an iaaaioaaeaiue ??cii? ni?yiiaaiino? ni?ey? iaio?e "iai?oaeaiino?" aiaa?iaieo iaoai?ci?a aia?aicaaacia/aiiy, ui aeyaeeiny a iaioiio iaeiie/aii? eaeoaoo, yea oaeiae ? iaeiei ?c /eiiee?a noiieaiiy (M. De Groot, 1993, G.W. Mainwood, 1995, J.M. Metzger, 1992), a e?ia? aeine?aeieo a?oi ii??aiyii c aei?iaoaaieie eiio?ieueieo a?oi (iae. 3). A?aeiia?aeii aei inoaii?o oyaeaiue i?e/eie ooeiaeaeaiiy ee?oeiieo ? noaee?oeiieo iaia?aiieo no?oeoo?, ye? i?ecaiaeyoue aei ii?ooaiiy aeoo iai?oaeaiiy ? ?icneaaeaiiy i'yciaiai aieieia, iia'ycothoue ?c iaaei??iith aeoea?caoe??th i?ioean?a ia?aeeneiai ieeneaiiy e?i?ae?a (IIE) (S. K. Donaldson, 1990, G. Karlsson, 1997). Aei 80-o ??. oe? ooeiaeaeaiiy iia'ycoaaee c aenieiaia?aaoe/iei oinoaoiei iaoai?ciii aia?aicaaacia/aiiy, iaeiie/aiiyi eaeoaoo, cieaeaiiyi pH (M. Hiller, 1972). Caaaeueiith iciaeith aeey oeeo ooeiaeaeaiue ? iaa?yeaiiy i?oioiiae??e. O oeueiio aeiaaeeo, ye na?ae/aoue ?acoeueoaoe iaoeo aeine?aeaeaiue, canoinoaaiiy ia?aae cia/ieie o?ce/ieie iaaaioaaeaiiyie e?ii?ai? eeneioe, yea ia? aeanoeaino? o?ieiaiai aioeieneaeaioa, ni?ey? iiia?aaeaeaiith iani?eyoeeaeo ci?i o i'yciaeo aieieiao ?, cie?aia, ?icaeoeo "iai?oaeaiiino?" i'yc?a, a, ioaea, cae?enith? ni?eyoeeaee aieea ia noai ii??ii-?ooiaiai aia?aoo. A?aeiii, ui oaeaee?ni? yeino? i?ae /an noiieaiiy (aai ia oii? iaiiaiiai caaa?oaiiy i?ioean?a a?aeiiaeaiiy) i?eai?/othoueny iaea?eueoith i??ith, a ?oiy aeeiai?ea caeaoia /?oei a?aeia?aaeaoe aoaeoeai?noue a?aeiiaethaaeueieo i?ioean?a (?.TH. Aiiaea?/oe, 1982). ?acoeueoaoe a?ao ia 60 i, ye? aecia/aeenue aei ? ianooiiiai aeiy i?ney 15-oe e?eiiao?iaiai i?ia?ao, na?ae/aoue i?i iaioee nooi?iue cieaeaiiy oeeo yeinoae o aeine?aei?e a?oi? nii?oniai?a, ui aeiaiaeeoue a??i?noue ia?aiiai i?aeoiaeo aei aeai?o caniao ei?aeoe?? iiaeoethth/iai aieeao na/iaeie ia noai aioeieneaeaioii? nenoaie i?ae /an iai?oaeaii? i'yciai? ae?yeueiino?. Iaaaaeai? o aeena?oaoe?ei?e ?iaio? ?acoeueoaoe aeine?aeaeaiue ua ?ac na?ae/aoue i?i oa, ui aea?? cania?a aeey i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino? o eiie?aoieo aeaeao nii?oo aaaeeeai cae?enithaaoe c o?aooaaiiyi niaoeeo?/ieo aeey ?oiuei? ae?yeueiino? a?ieia?/ieo i?ioean?a (?.Ae. Naeooea, 1998, A.I. Ac?cia 1998, M. Wiliams, 1997). A ia?aiiio aeiaaeeo aeey aeae?a nii?oo, ye? iio?aaothoue aeyao aeo?eaaeino?, aea/aiiy a?ieia?/ieo aoaeo?a na/iaeie ?, cie?aia, ?? aieea ia noai AI-nenoaie ?ice?eaa? iia? i?aeoiaee aeey iiooeo cania?a ? iaoiae?a i?aeaeuaiiy aoaeoeaiino? o?aioaaeueii? oa ciaaaeueii? ae?yeueiino?. Iaeiei ?c oaeeo cania?a, ye na?ae/aoue i?iaaaeai? aeine?aeaeaiiy, ? e?ii?aa eeneioa. Aeniiaee 1. Iiaeoethth/ee aieea na/iaeie (in vitro) ia noai aioeieneaeaioii? nenoaie caeaaeeoue a?ae ?? eiioeaio?aoe?? a e?ia?. 1.1 Na/iaeia o o?c?ieia?/ieo eiioeaio?aoe?yo, ye? a?aeiia?aeathoue ii?i? (a?ae 3,3 aei 7,5 iiieue SYMBOL 215 \f "Symbol" \s 12 * e-1), aeinoia??ii ia aieeaa? ia noai aioeieneaeaioii? nenoaie. 1.2 Iiaeoethth/ee aieea na/iaeie ia noai aioeieneaeaioii? nenoaie aeyaey?oueny o aeiaaeeao i?aeaeuaiiy ?? eiioeaio?aoe?? a e?ia?, ii/eiath/e c 10 iiieue SYMBOL 215 \f "Symbol" \s 12 * e-1. 1.3 I?iieneaeaioia ae?y na/iaeie ?aae?co?oueny /a?ac o?ie-aeenoeueo?aeio eaieo aioeieneaeaioii? nenoaie ca ?aooiie cieaeaiiy ai?noo caaaeueieo SH-a?oi a?ee?a oa oa?iaio?a, a oaeiae /a?ac cieaeaiiy aeoeaiino? noia?ieneaeaeeniooace oa eaoaeace. Aioeieneaeaioia ae?y – /a?ac i?eai?/aiiy ?i?oe?aoe?? eao?iiaie Fe2+ i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a. 2. Na/iaeia (in vitro) ?iceaaeith? i?io?eaiiy i?ioean?a aeeoaiiy oa oinoi?eethaaiiy a ?cieueiaaieo i?oioiiae??yo, iaa?oue o a?aeiinii iacia/ieo o?c?ieia?/ieo eiioeaio?aoe?yo (1,7 iiieue SYMBOL 215 \f "Symbol" \s 12 * e-1). Cia/i? ?? eiioeaio?aoe?? iiai?noth i?eai?/othoue ooieoe?th i?oioiiae??e. 3. I?e?iaeiee o?ieiaee aioeieneaeaio – e?ii?aa eeneioa – caiia?aa? i?iieneaeaioi?e ae?? na/iaeie. Iaa?oiooaaiiyi aeioe?eueiino? aaeeaaiiy aenieieaae?o?eiaaieie nii?oniaiaie e?ii?ai? eeneioe c iaoith i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino? i?ae /an cia/ieo iaaaioaaeaiue ye aa?iaiiai, oae ? aa?iaii-aiaa?iaiiai oa?aeoa?o iiaeooue aooe oae? ?? aoaeoe: caiia?aaiiy cieaeaiith a e?ia? eiioeaio?aoe?? caaaeueieo SH-a?oi; cieaeaiiy "iaoyaeaiino?" ae?eie?oe/ieo i?ioean?a, i?aeaeuaiiy aoaeoeaiino? aeei?enoaiiy aee??a ye aia?aaoe/iiai aeaea?aea aeey caaacia/aiiy i'yciai? ae?yeueiino?; aeya caoeniiai aoaeoo uiaei ooeiaeaeoth/iai aieeao i?iaeoeo?a ia?aeeneiai ieeneaiiy e?i?ae?a ia iii?ii-?ooiaee aiia?ao. 4. Ia?i?aeueia aaeeaaiiy e?ii?ai? eeneioe aeicith 600 ia a?aoiaie ia na?aaei? aeenoaioe?? aei i?ieiiaiaaiiai o?ce/iiai iaaaioaaeaiiy aa?iaii? ni?yiiaaiino? ni?ey? a?eueo oaeaeeiio i?io?eaiith a?aeiiaethaaeueieo i?ioean?a, ui aeyaey?oueny a a?eueo aoaeoeaiiio a?aeiiaeaii? iieacieea, yeee oa?aeoa?eco? aeya nii?oniaiaie oaeaee?nieo iiaeeeainoae. 5. C iiaeeaeaiiyi noaio iaaeia?aeiiaeaiiy i?ney cia/ieo o?aioaaeueieo iaaaioaaeaiue o a?aeiiaethaaeueiiio ia??iae? o a?aoi?a ia na?aaei? aeenoaioe?? a?aecia/a?oueny niaaeei?ii?noue o ia?aaaaeaeueiiio aeei?enoaii? aia?aaoe/ieo noano?ao?a – nii/aoeo aoaeaaiae?a, iio?i aee??a ? aiaeiaaiieo a?ee?a, ui ciaoiaeeoue a?aeia?aaeaiiy o iine?aeiai?e ci?i? eiioeaio?aoe?? iai?yieo iieaciee?a aeei?enoaiiy oeeo noano?ao?a (a?aeiia?aeii eaeoaoo, eaoiniieoe, na/iaeie). 6. Iae?e ?aieiai? aeeiai?ee eiioeaio?aoe?? a e?ia? oa?aeoa?eco? "iaoaaie?/iee oii a?aeiiaeaiiy", ui aena?oeth? noeeuei?noue nii?oniai?a aei aeeiiaiiy o?ce/ieo iaaaioaaeaiue aecia/aii? ni?yiiaaiino? oa iaa?oioiao? aea?? iioeiaeueiiai aa??aioo ei?aeoe?? o?ce/ii? i?aoeacaeaoiino?. 7. Io?eiaii? aeai? aeicaieythoue ?aeiiaiaeoaaoe e?ii?ao eeneioo aeey ei?aeoe?? noaio aioeieneaeaioii? nenoaie i?aai?cio nii?oniai?a, ui niaoe?ae?cothoueny o aeaeao nii?oo, ye? aeiaaathoue aeyao aeo?eaaeino?. I?aeoe/i? ?aeiiaiaeaoe?? Ia i?aenoaa? ?acoeueoao?a aeine?aeaeaiue c iaoith i?aeaeuaiiy o?ce/ii? i?aoeacaeaoiino? nii?oniai?a, ye? aeeiiothoue o?ce/i? iaaaioaaeaiiy ye aa?iaii-aiaa?iaiiai, oae ? aa?iaiiai oa?aeoa?o ?ic?iaeai? oae? ?aeiiaiaeaoe??: – c o?aooaaiiyi iniaeeainoae aeeiai?ee na/iaeie o e?ia? ?, cie?aia, i?ae /an cieaeaiiy /e i?aeaeuaiiy ?? ai?noo o eiiieaen? oa?iaeieia?/ieo cania?a ?aeiiaiaeo?oueny aeiaeaaaoe i?aia?ao ESPA–LIPON 600,300 (e?ii?ao eeneioo) aeicith 600ia per os ca 60–90 oaeeei aei cia/ieo o?ce/ieo iaaaioaaeaiue; – aaeeaaiiy i?ia?aei-a?oai?iieo eiiiiiaio?a, a?aoiaoth/e ia eiiieaeniooai?thth/? yeino? e?ii?ai? eeneioe, ?aeiiaiaeo?oueny i?eaeecii /a?ac 6–7 aiaeei i?ney ?? i?eeiio; – e?ii?aa eeneioa, ye o?ieiaee aioeieneaeaio, ?aeiiaiaeo?oueny aei aaeeaaiiy ca aeuacaaaeaiith noaiith c iaoith caiia?aaiiy ?icaeoeo oe?aeeeaeo iane?aee?a a?ae aeoea?caoe?? i?ioean?a IIE, a ia?oo /a?ao, ia na?oea oa i’yce; – aaeeaaiiy e?ii?ai? eeneioe ?aeiiaiaeo?oueny o aeaeao nii?oo, aea aeniaaeaiiy caian?a i’yciaiai ae?eiaaio ? oaeoi?ii cieaeaiiy ?o o?ce/ii? i?aoeacaeaoiino?, ine?eueee aiia /eieoue e?iio?iiio ae?th; – o aeiaaeeao ?iaeea?aeoaeueiiai iani?eeiyooy e?ii?ai? eeneioe ?aeiiaiaeo?oueny aaeeaaiiy ?? ai?aeo (e?iai?ae); – ?aeiiaiaeaoe?? c ei?aeoe?? noaio AI-nenoaie aeeiioaaoe ia i?ioyaii anueiai o?aioaaeueiiai i?ioeano, a eeoa i?ae /an aeeiiaiiy “oaea?ieo i?e?ioeeee?a” a i?aeaioia/iio oa ciaaaeueiiio ia??iaeao; – aeeiai?ea eiioeaio?aoe?? na/iaeie o e?ia? o aei?ineeo ? thieo nii?oniai?a ia? nai? iniaeeaino?, ye? aeyaeythoueny a a?eueo iecueeiio ii/aoeiaiio ??ai? (2,3–3,3 iiieue SYMBOL 215 \f "Symbol" \s 12 * e-1) ? a?eueo ae?aaeaieo aaniethoieo c?ooaiiyo ?? eiioeaio?aoe?? i?ney cia/ieo o?ce/ieo iaaaioaaeaiue o iieiaeeo nii?oniai?a, ui ?aeiiaiaeo?oueny a?aoiaoaaoe ye i?ae /an ae?aaiinoeee, oae ? i?ae /an aeai?o niiniao ei?aeoe?? aioeieneaeaioii? nenoaie. Ia?ae?e iaae?oeiaaieo i?aoeue 1. Oea/aiei I.A. Yooaeoeaiinoue i?eiaiaiey eeiiaaie eeneiou n o/aoii iiaeoee?othuaai aeeyiey ii/aaeiu ia ninoiyiea aioeieneaeaioiie nenoaiu aeey iiauoaiey oece/aneie ?aaioiniiniaiinoe nii?oniaiia a aeaeao nii?oa, o?aaothueo i?iyaeaiey auiineeainoe // Iaoea a ieeiieeneii nii?oa. – 1999. – ? 1. – N. 97-102. 2. Oea/aiei I.A. ?acoeueoaou enneaaeiaaiey iiaeoee?othuaai aeeyiey ii/aaeiu ia ninoiyiea aioeieneaeaioiie nenoaiu – eae i?aaeiinueea aeey auai?a n?aaenoa oeaeaiai?aaeaiiie ei??aeoeee oece/aneie ?aaioiniiniaiinoe nii?oniaiia // Na. iao/iuo o?oaeia “Oece/aneia ainieoaiea nooaeaioia oai?/aneeo niaoeeaeueiinoae” iiae ?aae. A?iaeiaa N.N.– Oa?ueeia: OOIE, 1999.– ? 3.– N. 4 –10. 3. Oea/aiei I.A. Aeeyiea ii/aaeiu ia ninoiyiea oeie-aeenoeueoeaeiiai caaia aioeieneaeaioiie nenoaiu e niinia ei??aeoeee oece/aneie ?aaioiniiniaiinoe nii?oniaiia n iiiiuueth oeieiaiai i?aia?aoa // Na. iao/iuo o?oaeia “Oece/aneia ainieoaiea nooaeaioia oai?/aneeo niaoeeaeueiinoae” iiae ?aae. A?iaeiaa N.N.– Oa?ueeia: OOIE, 1999.– ? 4.– N. 30 – 38. 4. Nioeueneee A.E., Caioeiaa E.E., Nooeiaie Ae.A., Aiaa/aaa E.A., Eiaueei A.E., Oea/aiei I.A. Iiauoaiea onoie/eainoe i?aaiecia e iai?yaeaiiie iuoa/iie aeayoaeueiinoe iooai ei??aeoeee ninoiyiey aai aioeieneaeaioiie nenoaiu // Iaoea a ieeiieeneii nii?oa. – 1999. – Niaoe. auione.– N. 87-92. 5. Oea/aiei I.A. Aeeyiea eeiiaaie eeneiou ia aeoeaecaoeeth eeieaeiiai iaiaia ai a?aiy i?iaeieaeeoaeueiie iuoa/iie aeayoaeueiinoe // Ca??. iaoe. i?aoeue “Iaaeaaia?ea, ineoieia?y oa iaaeeei-a?ieia?/i? i?iaeaie o?ce/iiai aeoiaaiiy ? nii?oo” i?ae ?aae. ??iaeiaa N.N.– Oa?e?a, 1998.– ? 5.– N. 24 – 25. 6. Oea/aiei I.A. Oa?iaeieiae/aneay ei??aeoeey oeie-aeenoeueoeaeiiai caaia aioeieneaeaioiie nenoaiu eae niinia iiauoaiey oece/aneie ?aaioiniiniaiinoe // Ca??. iaoe. i?aoeue “Iaaeaaia?ea, ineoieia?y oa iaaeeei-a?ieia?/i? i?iaeaie o?ce/iiai aeoiaaiiy ? nii?oo” i?ae ?aae. ??iaeiaa N.N.– Oa?e?a, 1998.– ? 6.– N.14 –15. 7. Oea/aiei I.A. Aeei?enoaiiy iieacieea eiioeaio?aoe?? na/iaeie a e?ia? oa neei? aeey ei?aeoe?? o?aioaaeueii? i?ia?aie a?aoi?a ia na?aaei? aeenoaioe?? // Iaoa?. ae?oai? Anaoe?. iaoe. eiioa?aioe?? ani??aio?a “Iieiaea nii?oeaia iaoea Oe?a?ie” 11-13 aa?aciy 1998 ?. – Euea?a: EAeOOAE. – 1998. – II /.– N. 123-128. 8. Oea/aiei I.A. Nioeueneee A.E. Ei??aeoeey ninoiyiey aioeieneaeaioiie nenoaiu eae niinia iiauoaiey onoie/eainoe i?aaiecia e iai?yaeaiiie iuoa/iie aeayoaeueiinoe (aiae) // The proceeding of “ The Modern Olympic Sports ” International scientific congress May 16-19, 1997 Kiev. – K., 1997. – P.48-49. 9. Oea/aiei I.A. Aieea na/iaeie ia ai?no noeueoa?ae?eeueieo a?oi a e?ia? ? o?ce/io i?aoeacaeaoi?noue aenia?eiaioaeueieo oaa?ei // Iaoa?. ia?oi? Anaoe?. iaoe. eiioa?aioe?? ani??aio?a aaeoc? o?ce/ia eoeueoo?a oa nii?o “Iieiaea nii?oeaia iaoea Oe?a?ie” 12-14 aa?aciy 1997 ? Euea?a. – Euea?a: EAe?OE. – 1997. – N. 145-146. 10. Oea/aiei I.A. Nioeueneee A.E. Aeeyiea ii/aaeiu ia i?ioeannu ieeneeoaeueiiai oinoi?eee?iaaiey a eciee?iaaiiuo ieoioiiae?eyo ia/aie yenia?eiaioaeueiuo aeeaioiuo // Oac. aeiee. Iaaeaeoia?. eiioa?. “ I?iaeaiu i?iaeoe?iaaiey ?aaeiia?iuo nenoai oece/aneiai ainieoaiey ” 27-29 ieoya?y 1997 a Ooea. – Ooea, 1997. – N. 89-91. Oea/aiei Iaoae?y Aieiaeeie??aia. Ei?aeoe?y iiaeoethth/iai aieeao na/iaeie ia noai aioeieneaeaioii? nenoaie i?aai?cio i?e iai?oaeai?e i’ycia?e ae?yeueiino?. Aeena?oaoe?y (?oeiien) ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaoe c o?ce/iiai aeoiaaiiy ? nii?oo c? niaoe?aeueiino? 24.00.01 – Ie?ii?enueeee ? i?ioan?eiee nii?o, Iaoe?iiaeueiee oi?aa?neoao o?ce/iiai aeoiaaiiy ? nii?oo Oe?a?ie, Ee?a, 1999. O aeena?oaoe?ei?e ?iaio? iaaaaeai? ?acoeueoaoe aeine?aeaeaiue, ye? a?aeia?aaeathoue iiaeoethth/ee aieea na/iaeie ia noai aioeieneaeaioii? nenoaie i?aai?cio ethaeeie. Iieacaii, ui na/iaeia o eiioeaio?aoe?yo, ye? a?aeiia?aeathoue noaio niieith (3,3 iiieue·e–1…6,6 iiieue·e–1), ia aieeaa? ia noai aioeieneaeaioii? nenoaie i?aai?cio. Iaeiae o eiioeaio?aoe?yo aeueo ca 10,0 iiieue·e–1 , ui ? oa?aeoa?iei aeey niaoeeo?/ii? ?aaeoe?? i?aai?cio ia cia/i? o?ce/i? iaaaioaaeaiiy, na/iaeia aeyaey? i?iieneaeaioiie aieea a?aeiinii aei o?ie-aeenoeueo?aeii? oa oa?iaioaoeaii? eaiie aioeieneaeaioii? nenoaie. Iaa?oioiaaii aea?? oa aeiaaaeaii aoaeoeai?noue aaeeaaiiy i?e?iaeiiai i?aia?aoo – e?ii?ai? eeneioe (ESPA-Lipon 600), yea ? o?ieiaei aioeieneaeaioii ? iiia?aaeaeo? i?iieneaeaioiee aieea na/iaeie, a oaeiae noeioeth? aeei?enoaiiy e?i?ae?a ye noano?ao?a aeey aia?aicaaacia/aiiy aeiaaio?eaaeeo o?ce/ieo iaaaioaaeaiue, ui iiceoeaii aieeaa? ia o?ce/io i?aoeacaeaoi?noue nii?oniai?a c aeae?a nii?oo, ye? iio?aaothoue aeyao aeo?eaaeino?. Eeth/ia? neiaa: aioeieneaeaioia nenoaia, iai?oaeaia i’yciaa ae?yeuei?noue, na/iaeia, e?ii?aa eeneioa (ESPA-Lipon 600), o?ce/ia i?aoeacaeaoi?noue. Oea/aiei Iaoaeuey Aeaaeeie?iaia. Ei??aeoeey iiaeoee?othuaai aeeyiey ii/aaeiu ia ninoiyiea aioeieneaeaioiie nenoaiu i?aaiecia i?e iai?yaeaiiie iuoa/iie aeayoaeueiinoe. Aeenna?oaoeey (?oeiienue) ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaoe ii oece/aneiio ainieoaieth e nii?oo ii niaoeeaeueiinoe 24.00.0I - Ieeiieeneee e i?ioanneiiaeueiue nii?o, Iaoeeiiaeueiue oieaa?neoao oece/aneiai ainieoaiey e nii?oa Oe?aeiu, Eeaa, 1999a. Enneaaeiaaii iiaeoee?othuaa aeeyiea ii/aaeiu a oeceieiae/aneeo eiioeaio?aoeee oa?aeoa?iuo aeey iai?yaeaiiie iuoa/iie aeayoaeueiinoe, ia ninoiyiea aioeieneaeaioiie nenoaiu e?iae. Iieacai eae aa aioeieneaeaioiue yooaeo, eioi?ue i?iyaeyaony a i?aiyonoaee eieoeeaoeee eaoeiiaie Fe2+ naiaiaeii–?aaeeeaeueiiai ieeneaiey (nieaeaao iaeiieaiea i?iaeoeoia, ?aaae?othueo n oeiaa?aeoo?iaie eeneioie), oae e i?iieneaeaioiia aeaenoaea ii ioiioaieth e oeie-aeenoeueoeaeiiio caaio, i?iyaeythuaany a iiauoaiee ieeneyaiinoe /?acau/aeii aaaeiuo a ooieoeeiiaeueiii ioiioaiee iaueo SH-a?oii e?iae e oa?iaioai aioeieneaeaioiie nenoaiu (noia?ieneaeaeeniooacu e eaoaeacu) a eiioeaio?aoeeyo auoa 10,0 iiieue·e–1. Ii/aaeia a oeceieiae/aneeo eiioeaio?aoeeyo niioaaonoaothueo ninoiyieth iieiy ( 3,3…6,6 iiieue·e–1) ia ieacuaaao nouanoaaiiiai aeeyiey ia enneaaeoaiua caaiuey aioeieneaeaioiie nenoaiu. A ?aaioa iieacaii oaeaea ?aciauathuaa aeaenoaea ii/aaeiu ia i?ioeannu ieeneeoaeueiiai oinoi?eee?iaaiey e oaiaoathuaa aeaenoaea aa aunieeo eiioeaio?aoeee ia oece/aneoth ?aaioiniiniaiinoue yenia?eiaioaeueiuo aeeaioiuo a oanoa G.F. Kiplinger (1967). Ia iniiaaiee iieo/aiiuo yenia?eiaioaeueiuo aeaiiuo i?aaeeiaeai niinia ei??aeoeee ninoiyiey aioeieneaeaioiie nenoaiu n iiiiuueth eeiiaaie eeneiou, eioi?ay i?aiyonoaoao i?iyaeaieth iaeioi?uo i?iieneaeaioiuo yooaeoia ii/aaeiu, e a /anoiinoe: – ieacuaaao aeaaii?eyoiia aeeyiea ia ninoiyiea oeie-aeenoeueoeaeiiai caaia aioeieneaeaioiie nenoaiu, eioi?ia i?iyaeyaony a i?aaeioa?auaiee nieaeaiey eiioeaio?aoeee SH-a?oii a e?iae, aucaaiiia auiieiaieai cia/eoaeueiuo oece/aneeo iaa?ocie; – nieaeaao "ioyaiu?iiinoue" aeeeieeoe/aneeo i?ioeannia ai a?aiy iai?yae?iiie iuoa/iie aeayoaeueiinoe; – noeioee?oao eniieueciaaiea aee?ia eae noano?aoia aeey yia?aiiaania/aiey, /oi n iaeiie noi?iiu, i?iyaeyao yeiiiiece?othuee yooaeo ii ioiioaieth e caianai aeeeiaaia e yaeyaony aeaaii?eyoiui i?e auiieiaiee ni?aaiiaaoaeueiuo e oi?aaeiaiee i?e eioi?uo caianu iuoa/iiai aeeeiaaia yaeythony iaeiei ec aaaeoueo oaeoi?ia, ia?aie/eaathueo oece/aneoth ?aaioiniiniaiinoue, a n ae?oaie noi?iiu, i?aaeioa?auaao iaaeaeaoaeueiiio cia/eoaeueiiio oaaee/aieth eiioeaio?aoeee ii/aaeiu a e?iae; – i?iyaeyao caueoiue yooaeo ii ioiioaieth e iia?aaeaeathuaio aicaeaenoaeth i?iaeoeoia IIE ia iii?ii-aeaeaaoaeueiue aiia?ao i?e iai?yaeaiiuo oece/aneeo iaa?oceao. – niinianoaoao aieaa auno?iio i?ioaeaieth ainnoaiiaeoaeueiuo i?ioeannia iinea i?ieiiae?iaaiiie oece/aneie iaa?ocee ay?iaiie iai?aaeaiiinoe, /oi i?iyaeyaony a aieaa yooaeoeaiii ainnoaiiaeaiee iieacaoaey, io?aaeathuaai i?iyaeaiea nii?oniaiaie nei?inoiuo aiciiaeiinoae. Iieo/aiiua aeaiiua iainiiauaatho oeaeaniia?aciinoue i?eiaiaiey eeiiaaie eeneiou ia?aae cia/eoaeueiuie iuoa/iuie iai?yaeaieyie, /oi iiauoaao yooaeoeaiinoue o?aie?iai/iie e ni?aaiiaaoaeueiie aeayoaeueiinoe nii?oniaiia niaoeeaeece?othueony a aeaeao nii?oa naycaiiuo n i?iyaeaieai auiineeainoe. Eeth/aaua neiaa: aioeieneaeaioiay nenoaia, iai?yaeaiiay iuoa/iay aeayoaeueiinoue, ii/aaeia, eeiiaaay eeneioa (ESPA-Lipon 600), oece/aneay ?aaioiniiniaiinoue nii?oniaiia. Tkachenko Natalia. Correction of the urea modulating influence on the state of athletes antioxidative system under the strain muscular activity. The thesis for the degree of Candidate of Science in speciality 24.00.01 - Olympic and Professional Sport, the National University of Physical Education and Sport of Ukraine, Kiev, 1999. The results of investigations reflect the process of the modulating influence of urea on the state of the antioxidative system in the body. As it has been shown the urea in the physiological concentrations (3.3...6.6 mmol SYMBOL 183 \f "Times New Roman" \s 12 · l-1) does not influence on the state of the antioxidative system. The urea concentrations which are more than 10 mmol SYMBOL 183 \f "Times New Roman" \s 12 · l-1 (natural concentrations under strain muscular activity) act as the prooxidant that is conditioned by the influence on the state of the thiol-disulphide and enzyme links of the antioxidative system. In the work the recommendations for using the ESPA-Lipton 600 as the thiol antioxidant for correction of prooxidant influence of the urea and as the substance which has lipotropic effect for improving the efficiency of the training and competitiv activity of the athletes in the kinds of sport connecting with the development of endurance are presented. Key words: antioxidative system, strain physical exercises, urea, ESPA-Lipon, physical performance of the athletes. PAGE 5

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