I?I?NOA?NOAI IOI?IIE CAeI?IA(ss OE?A?IE

OE?A?INUeEEE IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO

?i. I.I.Aiaiiieueoey

Ia i?aaao ?oeiieno

AEAENAIAe?OE Ieaenaiae? Aeieo?iae/

OAeE 616.521-022.7+615.83+615.322+616-08-059

EIIIEAENIA E?EOAAIIss I?E?IAII? AECAIE ?C AEEI?ENOAIIssI
I?E?IOAEEUeIAI? ?ACIIAINII? OA?AI?? OA NI??OE?IE.

14.01.20 – oe??i? oa aaia?e/i? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia a ?aaii-O?aie?anuee?e aea?aeaai?e iaaee/i?e aeaaeai??

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, aeioeaio,

Oea/ Aaneeue ?aoeo?eiae/,

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y, caa?aeoaa/ eo?no
oe??ieo oa aaia?e/ieo oai?ia

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?,

Eyoaiei ?aai Ieeeoi?iae/,

A?iieoeueeee iaaee/iee oi?aa?neoao, eaoaae?a oe??ieo oa aaia?e/ieo
oai?ia

aeieoi? iaaee/ieo iaoe, i?ioani?,

E?aa/aiei Aieiaeeie? A?eai?iae/,

Oe?a?inueea iaaee/ia noiiaoieia?/ia aeaaeai?y, caa?aeoaa/ eaoaae?e
oe??ieo oa aaia?e/ieo oai?ia

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe,
eaoaae?a oe??ieo oa aaia?e/ieo oai?ia, IIC Oe?a?ie, i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 20 “ o?aaiy 1999 ?ieo

i 13.30 aiaeei? ia can?aeaii? Niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.003.02
i?e Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i I.I.Aiaiiieueoey (252012,
i.Ee?a, aoeueaa? O.Oaa/aiea, 17).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. I.I.Aiaiiieueoey (aoe. Ciieia?/ia, 3).

Aaoi?aoa?ao ?ic?neaii “ 16 “ ea?oiy 1999 ?ieo

A/aiee nae?aoa? Niaoe?ae?ciaaii?

a/aii? ?aaee, aeieoi? iaaee/ieo iaoe
N.A.Nae?eae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie

Aeeeeeaia aio?iiiaaiiei aieeaii iia??oaiiy aeieia?/ii? neooaoe?? ?
iaeiith c i?e/ei nooo?aeo ci?i ?ioiieia?/ii? ?aaeoeaiino? ethaeeie. Oea
ni?e/eieei ca?eueoaiiy iioe?aiino? aea?a?/ieo oai?ia, ceiye?nieo
iiaioai?aiue oa iaaeoa, aeeeeeaieo oiiaii-iaoiaaiieie i?e?ii?aai?ciaie
(A.A.Aa?oeai?a,1990; A.?.Nieieia,1998). Ca aeaieie e?oa?aoo?e
(S.J.Yawalkar et al,1989; ?.A.Oac?cia oa ni?aaao.,1991) i?eaeecii
aeanyoa /anoeia ianaeaiiy na?oo oai??? ia aecaio. A ?iaeono??aeueii
?icaeiooeo e?a?iao oeae iieaciee nyaa? 30-40% (J.Venables et al,1995),
neeaaeath/e ii ie?aieo ?aa?iiao aei 53% an?o aea?a?/ieo aea?iaoic?a.
Aecaia ? iaei??th c iaea?eueo /anoeo oai?ia oe??e in?a iioeeiai oa
noa?a/iai a?eo (I.A.Ea?aaacyi oa ni?aaao.,1991). Iaoe??ioe, ui
oai??thoue oe??th iaaeoaith, neeaaeathoue 12-25% an?o aea?iaoieia?/ieo
oai?eo oa 35-45% na?aae oai?eo, ye? aini?oae?cothoueny a aea?iaoieia?/i?
a?aeae?eaiiy noaoe?iia??a (A.?.Ea?oia,1989; J.O.Holm,1994; A.A.Eoeaaa,
E.I.?iiaiaiei, 1997). Na?aae an?o aeiaaee?a aecaie i?e?iaia oi?ia
cono??/a?oueny a?eueo, i?ae o 25% oai?eo (E.A.Oea/aiei,1990). Oeae
iieaciee nooo?ai ca?eueoo?oueny ? ia?aaeuo? /anoioo aeieeiaiiy ?ioeo
oi?i aecaie i?e aiae?c? caoai?thaaiino? in?a noa?oeo a?eiaeo a?oi
(N.N.Oeeaaiie,1993).

A?aei?/aii, ui e?euee?noue aea?a?/ieo aea?iaoic?a acaaae? ? i?e?iaii?
aecaie (IA) cie?aia ia? oaiaeaioe?th aei c?inoaiiy, a na?aaeiueiio ia 5%
a ??e (TH.E.Ne?eieei, ?.A.Iao?iaa,1982; ?.Oieaa,1987; E.Ae.Eaethaeia oa
ni?aaao.,1988; A.A.Eoeaaa oa ni?aaao.,1997). O a?eueoino? oai?eo iaaeoaa
i?io?ea? oi?i?aeii, c /eneaiieie ?aoeeaeeaaie oa ei?ioeio?eaaeeie
?ai?n?yie; a oeeo aeiaaeeao /anoi ia aaea?oueny aeinyaiooe iiaiiai
ee?i?/iiai aeaeoaeaiiy iaa?oue i?e o?eaaeiio e?eoaaii?
(?.I.Eyoaiei,1986). I?iaeaia iaoiaaiaco oa e?eoaaiiy i?e?iaii? aecaie,
ia aeeaey/enue ia /eneaii? aeine?aeaeaiiy, caeeoa?oueny iaei??th c
aeooaeueieo i?iaeai ee?i?/ii? aea?iaoieia?? (A.I.Oaaeioia,1984;
M.Viktirinova et al.,1986,1988; I.TH.Oaeai?i,1990; J.C.Kasteler,1992;
N.N.Oeeaaiie,1993; I.Ae.Io?eoe?ia,1997).

A inoaii? ?iee a/ai? i?iiaaothoue aeei?enoiaoaaoe i?e?ioaeeueiao
?aciiainio oa?ai?th (I?O) a e?eoaaii? aea?a?/ieo aea?iaoic?a
(A.A.Eieyaeaiei oa ni?aaao.,1989; A.A.?aae?iiia,1992; I.N.Aonae,1993;
I.I.?iae?iiia oa ni?aaao, 1998; A.I.Noai?ia oa ni?aaao.,1998). O oai?eo
ia IA iiceoeaiee ee?i?/iee aoaeo niinoa??aaany i?e ii?ii?iaii? aiaieu
(A.I.Noai?ia oa ni?aaao., 1994) oa ii?aeiaii? iaoiaeo c
aieei?aoeaenioa?ai??th (I.Ae.Io?eoe?ia,1997). I?ioa iioe?ai?noue
aeneiaiue o cia/ii? /anoeie oai?eo oa iaiao?aei?noue iaae/ie
aieei?aoeaenioa?ai?? iiaeooue noaoe ia caaaae? oe?ieiio aeei?enoaiith
I?O i?aeoe/ieie aea?iaoieiaaie. Oea iaoiiaeth? aeooaeuei?noue iiooeo
a?eueo aoaeoeaiiai oa i?inoiai o aeeiiaii? iaoiaeo i?e?ioaeeueiai?
oa?ai?? aea?iaoico, eiai iaoiaaiaoe/iiai iaa?oiooaaiiy.

A e?oa?aoo?? a?aenooi? iia?aeiieaiiy i?i a?oioiaia aea/aiiy canoinoaaiiy
i?aia?aoo ni??oe?ie a e?eoaaii? oai?eo ia IA. A?aoiaoth/e ?ioi?iaoe?th
i?i aoaeoeai?noue oeueiai caniao a e?eoaaii? aioo??oiuei? iaoieia??
(M.A.Qureshi.et al, 1996; I.?.?oaei?a oa ni?aaao., 1996), iiaeia
ia?aaeaa/eoe, ui canoinoaaiiy ni??oe?ie oa I?O, yeei i?eoaiaiia
?ioiiiiaeoethth/a ae?y, ni?eyoeia nei?i/aiith o?eaaeino? e?eoaaiiy oa
iiaeiaaeaiith ?ai?n?? iaaeoae, i?aeaeueoue aoaeoeai?noue aaciai? oa?ai??
oai?eo ia i?e?iaio aecaio.

Ia?ae?/ai? aeua ia ae??oai? i?iaeaie e?eoaaiiy i?e?iaii? aecaie e
iaoiiaeee aeooaeuei?noue i?iaaaeaiiai aeine?aeaeaiiy, iaoo ? caaaeaiiy
?iaioe.

Ca(ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Iaoeiaa i?aoey aeeiiaia ca?aeii c ieaiii iaoeiai-aeine?aeieo ?ia?o
?aaii-O?aie?anueei? aea?aeaaii? iaaee/ii? aeaaeai?? ? ? o?aaiaioii
i?aeeaoaae?aeueii? iaoeiai-aeine?aeii? ?iaioe “Iaoiii?oic aea?iaoic?a o
ca(yceo c aieeaaie /eiiee?a aeiae?eey I?eea?iaooy ia i?aai?ci ethaeeie”
(?a?no?aoe?eiee iiia? 01.20/02.13/039-96i).

Iaoa ?iaioe

Iaoith ?iaioe aoei anoaiiaeaiiy iiaeo caeiiii??iinoae iaoiaaiaco
i?e?iaii? aecaie ? ?ic?iaea iia?oi?o oaoiieia?e e?eoaaiiy oaeeo oai?eo.

Caaaeaiiy ?iaioe

Aea/eoe noai ?ioiieia?/ii? ?aaeoeaiino?, ianiaoeeo?/ii? ?acenoaioiino?
oa aooii?e?ioei?e oe??e oai?eo ia i?e?iaio aecaio i?ae /an caaino?aiiy
iaaeoae.

Aeine?aeeoe ee?i?/io aoaeoeai?noue o?aaeeoe?eiiai eiieaeniiai e?eoaaiiy
a oiiaao aea?iaoieia?/iiai noaoe?iia?o ? eiai aieea ia iieacieee
?ioi?oaoo, ianiaoeeo?/ii? ?acenoaioiino? oa aooii?e?ioei?e oe??e.

?ic?iaeoe oa ai?iaoaaoe iaoiae e?eoaaiiy oai?eo ia i?e?iaio aecaio c
aeei?enoaiiyi i?e?ioaeeueiai? ?aciiainii? oa?ai??, ioe?ieoe eiai
ee?i?/io aoaeoeai?noue oa aieea ia noai ?ioiieia?/ii? ?aaeoeaiino?,
ianiaoeeo?/ii? ?acenoaioiino? ? aooii?e?ioei?e oe??e.

I?iaanoe aea/aiiy aieeao eiiieaenii? oa?ai?? ?c canoinoaaiiyi ni??oe?ie
ia aoaeoeai?noue e?eoaaiiy i?e?iaii? aecaie, iieacieee ?ioiii? nenoaie
oa aooii?e?ioei?e oe??e.

Anoaiiaeoe ee?i?/io aoaeoeai?noue oa aieea ia oaeoi?e ?ioiieia?/ii?
?acenoaioiino? ? iieacieee aooii?e?ioei?e oe??e eiiieaeniiai e?eoaaiiy
?c ii?aeiaiei canoinoaaiiyi i?e?ioaeeueiai? ?aciiainii? oa?ai?? oa
ni??oe?ie.

Iaoeiaa iiaecia

Aia?oa, caaaeyee no/aniei iaoiaeai aeine?aeaeaiiy, c(yniaaii iia?
aniaeoe iaoiaaiaco i?e?iaii? aecaie, cie?aia ?ieue ii?ooaiiy i?ioean?a
?aaoeyoe?? oa aeoeaiino? aoaeoi?ii? eaiee i?e ?aae?caoe?? ?ioiii?
a?aeiia?ae? o oai?eo ia IA, cia/aiiy ye?niiai neeaaeo aooii?e?ioei?e
oe??e ??cieo ae?eyiie a ia?aa?c? aea?iaoico. Aia?oa a eiiieaeniiio
e?eoaaii? oai?eo ia i?e?iaio aecaio aeine?aeaeaii ee?i?/io aoaeoeai?noue
aeei?enoaiiy ni??oe?ie, ae?noaa iiaeaeueoee ?icaeoie ? oaeineiiaeaiiy
iaoiae i?e?ioaeeueiai? ?aciianii? oa?ai??. ?ic?iaeaii iiaee aoaeoeaiee
aeeoa?aioe?eiaaiee iaoiae e?eoaaiiy iaaeoae ?c canoinoaaiiyi I?O,
ni??oe?ie aai ?o ii?aeiaiiy. I?iaaaeaii iaa?oiooaaiiy oa aeine?aeaeaii
aieea ?ic?iaeaiiai iaoiaeo e?eoaaiiy ia iieacieee ?ioi?oaoo oa noai
aooii?e?ioei?e oe??e oai?eo ia IA.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a

Aeey caeeaae?a ioi?iie caei?ia(y aea?iaoieia?/iiai i?io?eth
cai?iiiiiaaii aaeineiiaeaiee ? a oie aea /an i?inoee, aacia/iee o
aeei?enoaii?, c a?aenooi?ie iia?/iith ae??th oa oneeaaeiaiiyie iaoiae
e?eoaaiiy oai?eo ia i?e?iaio aecaio. ?ic?iaeaiee iaoiae e?eoaaiiy IA
aeinooiiee aeey oe?ieiai ai?iaaaeaeaiiy a i?aeoeeo ye a noaoe?iia?ieo,
oae ? aiaoeaoi?ieo oiiaao.

I?iaaaeai? aeine?aeaeaiiy aeicaieeee anoaiiaeoe, ui canoinoaaiiy
i?e?ioaeeueiai? ?aciiainii? oa?ai?? oa ni??oe?ie a eiiieaeniiio
e?eoaaii? oai?eo ia i?e?iaio aecaio i?eaiaeyoue aei a?eueo oaeaeei?
iiceoeaii? ee?i?/ii? aeeiai?ee ia?aa?ao caoai?thaaiiy, ii?iae?caoe??
ee?oeiii? ? aoii?aeueii? eaiie ?ioiieia?/ii? ?acenoaioiino? i?aai?cio,
noaio aooii?e?ioei?e oe??e.

I?iaaaeai? aeine?aeaeaiiy aeaaeooue ciiao i?aeoe/iei e?ea?yi iiaeeaeoe
ciaiiy i?i o/anoue ?ioiii? nenoaie oa aooii?e?ioei?e oe??e o oi?ioaaii?
oa ia?aa?ao i?e?iaii? aecaie.

Ai?iaaoe?y ?iaioe

Iaoa??aee aeena?oaoe?? aeiiia?aeaeeny ? iaaiai?thaaeeny ia
iaoeiai-i?aeoe/i?e eiioa?aioe?? aea?iaoi-aaia?ieia?a Cao?aeiiai ?aa?iio
Oe?a?ie (Niyoei, 1998), iaeani?e iaoeiai-i?aeoe/i?e eiioa?aioe??,
iaeaniiio iaoeiaiio oiaa?enoa? aea?iaoiaaia?ieia?a (?aaii-O?aie?anuee,
1998), i?aenoieia?e iaoeia?e eiioa?aioe?? iaaee/ii? aeaaeai??
(?aaii-O?aie?anuee, 1999).

Ioae?eaoe??

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 11 ?ia?o, ?c ieo 3 o
aeo?iaeueieo aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie aeey ioae?eaoe??
?acoeueoao?a aeena?oaoe?eieo aeine?aeaeaiue. Ia?ae?e ?ia?o, eio??
i?noyoue aieiai? iieiaeaiiy aeena?oaoe??, ui aeiinyoueny ia caoeno,
iaaaaeaii a e?ioe? aaoi?aoa?aoo.

?aae?caoe?y ?iaioe

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a e?eoaaeueii-ae?aaiinoe/iee
i?ioean noaoe?iia?iiai a?aeae?eaiiy iaeaniiai aea?iaoi-aaia?ieia?/iiai
aeeniaina?o ? aea?iaoieia?/ieo eaa?iao?a i?nueeeo oa iaeanieo
iie?ee?i?e, canoiniaoaaeenue i?e e?eoaaii? oai?eo ia i?e?iaio aecaio o
?aeiiieo aea?iaoieia?/ieo noaoe?iia?ao oa iie?ee?i?eao. Iaoa??aee
aeena?oaoe?? aeei?enoiaothoueny a iaa/aeueiiio i?ioean? ia eo?nao
oe??ieo oa aaia?e/ieo oai?ia ?aaii-O?aie?anueei? oa Aoeiaeinueei?
aea?aeaaieo iaaee/ieo aeaaeai?e i?e aea/aii? oaie “Aea?a?/i? naa?aey/?
aea?iaoice”.

Ca ?acoeueoaoaie aeena?oaoe?? i?aeaioiaeaii aei ioae?eaoe??
?ioi?iaoe?eiee eeno: “Iaoiae eiiieaenii? oa?ai?? i?e?iaii? aecaie ?c
aeei?enoaiiye ni??oe?ie oa i?e?ioaeeueiai? ?aciiainii? oa?ai??” oa
?ic?iaeaii 1 ?aoe?iiae?caoi?nueeo i?iiiceoe?th: “I?enoinoaaiiy aeey
i?iaaaeaiiy i?e?iiaoiae?a aeine?aeaeaiiy ee?oei e?ia?” (?7/2344 ?OAeIA).

Aeaeea?aoe?y iniaenoiai aianeo aeena?oaioa a ?ic?iaeo iaoeiaeo
?acoeueoao?a, ui aeiinyoueny ia caoeno

Aaoi? aeeiiaa iiooe e?oa?aoo?ieo aeaea?ae, aea?aa oaio aeine?aeaeaiiy,
aeia?a i?ei??oaoi?noue, aeioe?euei?noue ? iaiao?aei?noue aeaii? iaoeiai?
i?aoe?, aecia/ea iaoo, caaaeaiiy, ia(?i oa iaoiaee aeine?aeaeaiiy, yeeie
aeineiiaei iaieiae?a, i?ieoiaoe eo?ne oa io?eiaaoe a?aeiia?aeiee
na?oeo?eao aei eeanoa?ii? ae?aaiinoeee noaio ?ioiii? ?aaeoeaiino?.
Aeena?oaioii i?iaaaeaii ee?i?ei-?ioiieia?/ia ianoaaeaiiy oai?eo,
iaaeaiiy ?i e?eoaaeueii? aeiiiiiae c i?iaaaeaiiyi i?ioeaaeo? I?O,
aeeiiai? ia?iaea io?eiaieo aeaieo, aiae?c ? ocaaaeueiaiiy ?acoeueoao?a
aeine?aeaeaiiy, iine?aeiaia ai?iaaaeaeaiiy ?o o i?aeoeeo; iaienaiy an?o
?icae?e?a aeena?oaoe?? oa i?aeaioiaea iaoeiaeo i?aoeue aei ae?oeo.

Ianya ? no?oeoo?a aeena?oaoe??

Aeena?oaoe?y iiaoaeiaaia ca caaaeueiii?eeiyoei ieaiii ? neeaaea?oueny c
anooio, iaeyaeo e?oa?aoo?e, iieno ia(?eoo oa iaoiaeee aeine?aeaeaiiy,
?icae?eo aeanieo niinoa?aaeaiue, iaaiai?aiiy ?acoeueoao?a, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, aeac?aieea e?oa?aoo?e oa aeiaeaoe?a.
Iaoa??aee aeena?oaoe?? aeeeaaeaii ia 120 noi??ieao. Aeena?oaoe?y
i?noeoue 19 oaaeeoeue oa 52 ?enoiee. A?ae?ia?ao?/iee aeac?aiee
e?oa?aoo?e aeeth/a? 285 aeaea?ae, c ieo 106 — ?iicaiieo aaoi??a.

CI?NO AeENA?OAOe??

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Aeey ae??oaiiy iinoaaeaieo a ?iaio? caaaeaiue ianoaaeaii 105 oai?eo ia
i?e?iaio aecaio, ye? ia?aaoaaee ia noaoe?iia?iiio e?eoaaii? a iaeaniiio
aea?iaoi-aaia?ieia?/iiio aeeniaina?? (i.?aaii-O?aie?anuee) oa 24
i?aeoe/ii caei?ia? iniae. Na?aae oai?eo /ieia?e?a aoei 76 (72%), ae?iie
– 29 (28%). A?eueoa 2/3 an?o iaoe??io?a aoee a?eii noa?oa 40 ?ie?a. O
iieiaeie oai?eo (49,5%) aea?iaoic iaa o?ii?/iee ia?aa?a, a cia/ii?
/anoeie (20%) niinoa??aaeinue a?eueoa /ioe?ueio iiia?aaei?o caaino?aiue.
Eeoa 17,1% iaoe??io?a caa?ioeenue ca iaaee/iith aeiiiiiaith i?ioyaii
oeaeiy a?ae iiyae aeneiaiue.

Aeey i?iaaaeaiiy e?eoaaiiy an? oai?? aoee ?iciiae?eai? ia 4 a?oie.
Iaoe??ioe ia?oi? (aaciai?) a?oie a e?eueeino? 27 /ieia?e io?eioaaee
aaciaa eiiieaenia e?eoaaiiy: a?iinainea?e?coth/?, aeieaoi?e H1
?aoeaioi??a, caniie?eeea?, iie?oa?iaioi? i?aia?aoe, aeia/aa?ii? oa
aaiaoii?ioaeoi?e, iineaaethth/?, aioa?ini?aaioe.; i?e iciaeao
?iiaoeaai?caoe?? aioeaaeoa??aeuei? i?aia?aoe oe?ieiai niaeo?o ae?? a
na?aaeiueiaeiaiaeo aeicao eo?naie ii 5-7 aei?a; caniae ciai?oiuei?
oa?ai??; oiiioi?ac ?c noa?i?aeieie e?aiaie, ?iaeoeoioa?i?th ae?eyiee
iaaeie?iee?a, oaie? i?noeaa? ? caaaeuei? aaiie ?c cai?aie c e?ea?nueeeo
o?aa.

Oai?ei ae?oai? a?oie a e?eueeino? 26 /ieia?e, ii?yae ?c aaciaei
e?eoaaiiyi, i?ecia/aee i?e?ioaeeueiao ?aciiainio oa?ai?th; 26 iaoe??ioai
o?aouei? – ni??oe?io; 26 oai?ei /aoaa?oi? — i?e?ioaeeueiao ?aciiainio
oa?ai?th ? ni??oe?io.

Aecia/aee ai?no eaeeioeeoa?ieo ee?oei oa eaeeioeeoa?io oi?ioeo
ia?eoa?e/ii? e?ia?, caa?aii? caaaeueiii?eeiyoei iaoiaeii c iaeueoey
eeoeoe? oa ciie, ui aaciina?aaeiuei i?eeyaa? aei aiaieua aecaie.

Aeei?enoiaoth/e iaoiaeeeo ?aaeoe?? ooai?aiiy ?icaoie, i?iaiaeeee
aecia/aiiy e?ioioeeoa?ieo iiioeyoe?e oa noaiiioeyoe?e caaaeueieo O-, A-,
Ae- oa 0-e?ioioeeo?a (O.?.Aaoeiaa, 1978), oaio?e?i/ooeeaeo
O-e?ioioeeo?a-noi?ani??a oa oaio?e?i?acenoaioieo O-e?ioioeeo?a-oaeia??a
(Limatibul et al., 1978), “aeoeaieo” O-e?ioioeeo?a (Kerman et al.,
1976), O-e?ioioeeo?a-noi?ani??a, ye? ?aaoeththoue aooi?ioii? i?ioeane
(Caroux et al., 1979).

Ia?aeaeueii iai?yiei ?ioiioeoi?anoeaioiei iaoiaeii oeyoii oa?aoaaiiy
ee?oei a iiiioa?? (A.O.Oaa?inii oa ni?aaao., 1989) ?c iaoei
aaeineiiaeaiiyi (?7/2344 ?OAeIA) aecia/aee ai?no iiiiioeeaa??a
ia?eoa?e/ii? e?ia? ca ia?ea?aie: CD3, CD4, CD8, CD24, CD56, CD150/IIO3
oa HLA-DR/?II47. A ?iaio? aeei?enoiaoaaee iiiieeiiaeuei? aioeo?ea o??ie
Sigma (NOA) oa ?inoeoooo aenia?eiaioaeueii? iaoieia??, iieieia?? oa
?aae?ia?ieia?? ?i. ?.? Eaaaoeueeiai IAI Oe?a?ie.

Aecia/aee ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a (O.?.Aaoeiaa, 1978),
eiioeaio?aoe?th ?ioiiaeiaoe?i?a A, I, G ne?iaaoee e?ia? ca iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? (G.Mancini et al., 1965) o iiaeeo?eaoe??
Fahey i McKelvey (1987), aeoeai?noue ne?iaaoeiaiai e?cioeeio ca
I.A.Aooa??iei (1986).

Noai aeeaiei? aooii?e?ioei?e oe??e ia iaooeiaeaeai?e ae?eyioe?
caeiaeueii? iiaa?oi? ia?aaeie?//y oa ciie, ui aaciina?aaeiuei i?eeyaaea
aei iniiaiiai aiaieua aeneiaiue, aea/aee ca iaoiaeeeith aiaieuaaeo
a?aeaeoe?a I.I.Eeaiia?nueei? (1978). Eoeueoo?e noao?eieiea
?aeaioeo?eoaaee ca aeaeiaith iaeaaei?noth ca aeiiiiiaith oano-nenoaie
Staphi-Test (Lachema, *anueea ?anioae?ea).

Ia?iaea io?eiaieo aeaieo i?iaiaeeeanue iaoiaeii aa??aoe?eii? noaoenoeee
ca aeiiiiiaith eiiiuethoa?iiai i?ia?aiiiai caaacia/aiiy Statistica for
Windows (Release 4,3; Stat Soft, Inc.)

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy.

Io?eiai? iaie aeai? ni?acao/i? c aeoieith Henstein (1980),
A.E.Iaoe?eaeniia oa ni?aaao. (1982), A.A.Eaeaia?eyia (1982),
E.Ae.Eaethaeii? (1988) i?i oa, ui aea?a?/ia oai?iaa ? ii noo?
aeenaaeainii ?aaoeyoi?ieo iaoai?ci?a ?ioiii? a?aeiia?ae?, ine?eueee
ii?ooaiiy i?ioean?a aeic??aaiiy ? aeeoe?aioe?thaaiiy ie?aieo
noaiiioeyoe?e O-e?ioioeeo?a, ??aiiaaae i?ae noeioeyoi?ieie oa
aaeuei?aieie aieeaaie aaaeooue aei ?icaeoeo aea?a?/ieo ?aaeoe?e, a i?e
o?eaaeiio ia?aa?c? – aei ?icaeoeo aea?a?/ii? oai?iae. Iica caeaaei?noth
a?ae o?eaaeino? inoaiiueiai caaino?aiiy o oai?eo ia IA ia oii?
?icai?iooeo ee?i?/ieo i?iya?a ie niinoa??aaee cia/ii ieae/ee a?aenioie
(32,14(2,18 %; ?(0,05) oa ai?no ii a?aeiioaiith aei an?o eaeeioeeo?a
iiioeyoe?? ?icaoeiooai?thth/eo O-e?ioioeeo?a (ca?eueoaiiy
eaeei-O-ee?oeiiiai ?iaeaeno aei 11,54(0,98, ?(0,05). Aiaeia?/i? aeai?
iaea?aeai? ? i?e i?ae?aooieo CD3+ e?ioioeeo?a. Oea ciaioaiiy coiiaeaii
ae?aaeaiei cieaeaiiyi a?aenioeo (aei 21,18(1,18%, ?(0,001) oa e?eueeino?
(aei 375,29(84,98(106/ie, ?(0,05) noaiiioeyoe?? ?icaoeiooai?thth/eo
O-oaeia?ieo ee?oei, CD4+ ?iaeoeoi?ieo O-e?ioioeeo?a (a?aeiia?aeii aei
32,56(1,78%, ?(0,01; aei 524,30(41,94(106/ie, ?(0,05). Cieaeai? oaeiae
e?euee?ni? iieacieee ee?oei ?icaoeiooai?thth/i? O-noi?ani?ii?
noaiiioeyoe?? (aei 12,04(2,32%, ?(0,01; 189,08(55,08(106/ie, ?(0,05),
aiane?aeie /iai i?e iinooieaii? o oai?eo O-oaeia?ii-noi?ani?iee ?iaeaen
?noioii ia ??cieany a?ae ii?ie (1,96(0,48%, ?(0,05). Ca?eueoaiiy ae
a?aenioeo CD8+ oeeoioiene/ieo e?ioioeeo?a (aei 39,96(1,48%, ?(0,01)
aeeeeeaei i?aeoe/ii iiaeai?iiy ?iaeaeno CD4/CD8 (0,83(0,08, ?(0,01).
I?aeaeuaiith o oai?eo ? e?euee?noue (344,78(24,22(106/ie, ?(0,05) oa
a?aenioie (20,64(1,12%, ?(0,01) aeoeaiaaieo HLA-DR+ O-e?ioioeeo?a.
Aeinoia??ii c?inoa? e?euee?noue oa ai?no O-e?ioioeeo?a-noi?ani??a
aooi?ioiieo i?ioean?a (a?aeiia?aeii 47,33(13,12(106/ie, ?(0,05;
3,02(0,84%, ?(0,05). Ciaioaiiy e?eueeino? a e?ia? (223,87(52,44(106/ie,
?(0,05) ? a caaaeuei?e ian? e?ioioeeo?a (eaeei-A-ee?oeiiee ?iaeaen ae??n
aei 28,16(3,42, ?(0,01) oa?aeoa?ia aeey iiioeyoe?? ?icaoeiooai?thth/eo
A-e?ioioeeo?a. Aeai? aecia/aiiy CD24+ e?ioioeeo?a aena?oeththoue
iiae?ai? ci?ie. A?aenioie aea ? e?euee?noue aeoeaiaaieo (CD150+)
A-e?ioioeeo?a cia/ii c?inee (a?aeiia?aeii 10,72(0,88% ?(0,001;
174,56(16,56(106/ie, ?(0,01). Aeinoia??iei ? ca?eueoaiiy o oai?eo ia IA
ai?noo iiioeyoe?? “ioeueiaeo“ e?ioioeeo?a, ia?aaaaeii ca ?aooiie
i?e?iaeieo e?ea?ieo ee?oei (27,24(1,46% i?ioe 17,42(3,24% o caei?iaeo).

Ia niinoa??aaeinue ae?aaeaieo a?aeoeeaiue a?ae ii?iaeueieo cia/aiue c
aieo ne?iaaoeiaeo ?ioiiaeiaoe?i?a eeano G oa A o a?eueoino? oai?eo
(a?aeiia?aeii o 81% oa 88% iaoe??io?a), i?ioa caeeoaeanue aeinoaoiuei
aenieith eiioeaio?aoe?y ne?iaaoeiaiai e?cioeeio. Oi/ o 89% oai?eo
??aaiue Oe?E ne?iaaoee e?ia? ia aeoiaeea ca iaae? ii?iaeueiiai
ae?aiaciio, o a?eueoino? c ieo a?i ia?aaoaaa ia aa?oi?e iaae? cia/aiue
ii?ie. Aeinoia??ii cieaeaiith o 2/3 aecia/aeanue eiioeaio?aoe?y
ne?iaaoeiaiai ?ioiiaeiaoe?io I.

I?aeaeuaia e?euee?noue i?e?ii?aai?ci?a ia iaeeieoeth ieiu? aeyaeyeanue a
ae?eyieao aaciina?aaeiuei a?ey aiaieu aecaie o 81,9%, ia a?aeaeaeaieo
ciiao — o 65,8% oai?eo. A?eueoee ai?no, i?ae o caei?iaeo in?a, a neeaae?
aeeaiei? aooii?e?ioei?e oe??e (AAIO) caeiaee a?ai-iaaaoeai? aaeoa???
(a?ey aiaieu a 20%, ia a?aeaeaeaieo ciiao a 23,9% i?ioe 8,3% aeiaaee?a o
caei?iaeo) oa noao?eieiee (a?aeiia?aeii a 87,6% oa 80% i?ioe 58,3%
aeiaaee?a o caei?iaeo). Na?aae noao?eieie?a aeii?ioaaa cieioenoee
noao?eieie (a 38,0% a?ey aiaieu oa a 27,4% ia ?ioaeoi?e oe???) ?
aeinoia??ii iaioa, i?ae o caei?iaeo in?a, iioe?ai? eiaaoeaciiaaaoeai?
aeaee Staphylococcus epidermidis (a?aeiia?aeii 18,5% oa 28,6%) oa
Staphylococcus simulans (a?aeiia?aeii 4,3% oa 3,6%). A?aei?ii?noue AAIO
??cieo ae?eyiie o oai?eo ia IA iieyaaea a ?ioaineai?oiio i?e?iaiiio
canaeaii? a iaaeieiaiaieuaaeo ciiao oa ae?aaeaiiio ca?eueoaii? /enea
aeiaaee?a aen?aaiiy noao?eieieo ? eiai cieioenoiai ooaio cie?aia.

Ioaea, o oai?eo ia IA niinoa??aaany ae?aaeaiee aeenaaeain ee?oeiii?
eaiee ?ioi?oaoo oa iaaei??ia i?e?iaia ian?iai?iiy oe??e.

Ia iiiaio ?aa?ano aeaiaio?a aeneiaiue i?ney aaciaiai e?eoaaiiy /anoeia
iieaciee?a ?ioiia?aie oa AAIO caeeoaeenue a?aei?iiith a?ae ii?iaeueieo
cia/aiue. A ae?eyieao a?ey aiaieu aecaie caa??aaeanue e?ioioeeoa?ia
?io?eueo?aoe?y (?iaeaen II/E i?aeoe/ii a 1,5 ?ac?a iaioee, i?ae a
a?aeaeaeaieo ae?eyieao). Eaeei-CD3-ee?oeiiee ?iaeaen (6,01(1,02 i?ioe
4,86(0,98 o caei?iaeo) aeacoaaa ia ieae/ee ii a?aeiioaiith aei ?ioeo
eaeeioeeo?a ai?no O-e?ioioeeo?a. Aeinoia??ii iaioei, oaeiae, caeeoeany
a?aenioie O-ee?oei a caaaeuei?e ian? e?ioioeeo?a (55,92(1,56% i?ioe
70,30(8,66% o caei?iaeo). Iaaiaee, iaaei??ii aenieeie, ye ? aei
e?eoaaiiy, aoee a?aenioie (19,54(1,06% i?ioe 13,10(3,56% o caei?iaeo) ?
e?euee?noue (375,00(76,62(106/ie, o caei?iaeo 245,06(48,28(106/ie)
aeoeaiaaieo (HLA-DR+) O-e?ioioeeo?a.

Caeeoeeenue cieaeaieie aaniethoia e?euee?noue oa a?aenioie ee?oei
O-oaeia?ii?, ?iaeoeoi?ii? ? noi?ani?ii? (oaio?e?i-/ooeeai?)
noaiiioeyoe?e. A?aenioie oeeoioiene/ieo (CD8+) O-e?ioioeeo?a caeeoeany
i?aeaeuaiei (39,04(5,01% i?ioe 32,14(2,41% o caei?iaeo, ?(0,01).
Ni?a?aeiioaiiy Ooaeia??a/Onoi?ani??a ca?eueoeeinue aei 8,90(0,81 (o
caei?iaeo 8,68(0,92), aeacoth/e ia iiaeeaeaiiy iaaeinoaoiino?
aaeuei?aiiai aieeao ia iaaei??ii aeoeaiaai? ee?oeie. Caa??aaeanue
aeeni?iii?oe?ei?noue CD4+ oa CD8+ e?ioioeeoa?ieo e?i?e (CD4/CD8 ?iaeaen
aaea?/? iaioa ca ii?io). Ii a?aeiioaiith aei caaaeueii? eaeeioeeoa?ii?
iane e?euee?noue A-e?ioioeeo?a a aaiioee?eoeyoe?? ? ia aeae? aoea
cieaeaiith (eaeei-A-ee?oeiiee ?iaeaen 25,00(1,48 i?ioe 16,33(2,04 o
caei?iaeo). *enei ? a?aenioie aeoeaiaaieo (CD150+) A-e?ioioeeo?a
caeeoeeenue aaea?/? i?aeaeuaieie.

AO ni?eyea ciaioaiith a?aenioeo “ioeueiaeo” ee?oei oa i?e?iaeieo
e?ea??a, iaeiae ii?iae?caoe?? oeeo iieaciee?a ia a?aei?/aii, caa?aaeinue
a?aeiinia ca?eueoaiiy e?eueeino? “ioeueiaeo” ii a?aeiioaiith aei O- ?
A-e?ioioeeo?a (?iaeaen O+A/0 aoa 1,09(0,12 i?ioe 1,71(0,11 o caei?iaeo),
i?e?iaeieo e?ea??a aei CD3+ ? CD24+ ee?oei (?iaeaen CD3+CD24/iE
3,21(0,56 i?e 4,81(0,95 o caei?iaeo). Na?aaei?e ??aaiue ne?iaaoeiaiai
IgM caeeoaany cieaeaiei (1,01(0,08 i?e 1,58(0,12 o caei?iaeo).

Caaaeueia e?euee?noue eieii?e AAIO ia ci?ithaaeanue ? oo?eioaaeanue a
cia/ii? /anoeie oai?eo i?aeaeuaiith. A ye?niiio a?aeiioaii? i?ney
aaciaiai e?eoaaiiy nooo?aeo ci?i ia a?aeaoaaeinue.

C iaoith aea/aiiy aieeao ia ee?i?/io aoaeoeai?noue e?eoaaiiy ? aeeiai?eo
iieaciee?a ?ioi?oaoo oa aooii?e?ioei?e iaoiae?a oa?ai?? ?c
?ioiiiiaeoethth/eie aeanoeainoyie oai?ei ia IA ?ioeo a?oi aei aaciaiai
e?eoaaiiy aeiaeaaaee I?O, ni??oe?io aai ?o ii?aeiaiiy.

Iieacieee ?ioiia?aie oa noaio AAIO i?ney e?eoaaiiy ?c aeeth/aiiyi
cai?iiiiiaaieo iaie iaoiae?a a?ae??ciyeenue a?ae iieaciee?a, io?eiaieo
i?ney aaciaiai e?eoaaiiy, ? aoee iai/iei i?aeoaa?aeaeaiiyi
?ioiiiiaeoethth/eo aeanoeainoae I?O oa ni??oe?ie. I?e ii?aeiaii?
e?eoaaiiy ?c I?O a ia?eoa?e/i?e e?ia? ca?eueoeeinue /enei oa ai?no
e?ioioeeo?a ii a?aeiioaiith aei naaiaioiyaea?ieo ? iiiioeeoa?ieo ee?oei
(?iaeaen II/e ciaioeany aei 2,01(0,07 i?ioe 2,26(0,09 aei e?eoaaiiy).
A?ey aiaieu aecaie a e?ia? ciaiooaaany ai?no e?ioioeeo?a ye a
aaniethoieo /eneao, oae ? ii a?aeiioaiith aei oaaioeeoa?ieo ee?oei
(?iaeaen II/E c??aiyany c iieacieeii ia iaooeiaeaeaieo ae?eyieao).
Aeinoia??ii c?inoaea e?euee?noue ?icaoeiooai?thth/eo caaaeueieo
O-e?ioioeeo?a (eaeei-O-ee?oeiiee ?iaeaen ii?iae?coaaany), a oaeiae ?o
a?aenioie a caaaeuei?e ian? eaeeioeeo?a. *enei HLA-DR ee?oei
ii?iae?coaaeinue, ?o a?aenioie nooo?ai ciaioeany (c 21,27(5,61% aei
16,77(0,44%, ?(0,01). Iieacieee O-oaeia??a i?ney eo?n?a I?O aeinoia??ii
(?(0,01) c?inee ? aeinyaioee na?aaei?o cia/aiue a caei?iaeo ethaeae.
Ii?iae?coaaeanue aaniethoia e?euee?noue O-noi?ani??a, cia/ii (?(0,01)
c??n ?o a?aenioie. Aeinya ii?ie oaeia?ii-noi?ani?iee ?iaeaen, ui
aeacoaaei ia ae??aithaaiiy ?ioaineaiino? i?ioean?a
aaeueioaaiiy-caoaeaeaiiy. A?aenioie oeeoioiene/ieo (CD8+) e?ioioeeo?a
ciaioeany (?(0,05). Cieceeanue e?euee?noue aooi?icaoeiooai?thth/eo
O-e?ioioeeo?a (?(0,01). I?ney naain?a I?O i?aeoe/ii ii?iae?coaaeenue
iieacieee aeoeaiaaieo (CD150+) A-e?ioioeeo?a, ui na?ae/eoue i?i noeoaiiy
aino?ioe i?ioeano. ?ioaineai?oa, i?ae i?ney AO, ciaiooaaany a?aenioie
“ioeueiaeo” e?ioioeeo?a (?(0,01), i?e?iaeieo e?ea??a (?(0,01) oa
c?inoaee ?iaeaene O+A/I ? CD3+CD24/IE (?(0,05). Ia ne?iaaoeia? oaeoi?e
(IgG, IgM, IgA, Oe?E, e?cioeei) ii?aeiaia c I?O aaciaa e?eoaaiiy nooo?ai
ia aieeaaei.

I?ney e?eoaaiiy c aeei?enoaiiyi I?O ciaiooaaeinue /enei oai?eo ?c
iaaei??iei (a?ey aiaieu ia 28%, ?(0,05) ? nooe?eueiei (a?ey aiaieu ia
34%, ?(0,01) ?inoii eieii?e ia ieanoeieao-a?aeaeoeao. Aeinoia??ii
cieaeoaaeanue (ia 20% ia ?ioaeoi?e oe???, ?(0,05; ia 43% a?ey aiaieu,
?(0,01) /anoioa aeyaeaiiy noao?eieie?a. Aeaui ??aeoa (??cieoey
iaaeinoia??ia) aen?aaee a?ai-iaaaoeai? aaeoa???. Iioe?ai?noue
cieioenoiai noao?eieieo cieceeanue ia 5-7% (?(0,05), a iaea?eueo /anoei,
ye ? o caei?iaeo ethaeae, noaa ai?aea?iaeueiee noao?eieie (a 27-29%
aeiaaee?a). A?ey aiaieu aeneiaiue i?ney I?O aeuaiacaai? ci?ie aoee
ae?aaeai? cia/ii ?ioaineai?oa: canaeaiiy oe??e i?e?ii?aai?ciaie oa
ye?niee neeaae AAIO iaea?eueoa iii?ae on?o a?oi iaaeeceeenue aei
ii?iaeueieo cia/aiue.

Canoinoaaiiy ni??oe?ie a eiiieaen? e?eoaaiiy ni?eyei a?eueo oaeaeeiio
c?inoaiith /enea O-e?ioioeeo?a a aaiioee?eoeyoe??, ?o a?aenioeo iii?ae
e?ioioeeoaie (??0,05). *enei aeoeaiaaieo O-e?ioioeeo?a (HLA-DR+)
aeinoia??ii ciaioeeinue ? aeinyaei ii?ie. Aei ii?ie iaaeeceeinue oaeiae
aaniethoia /enei oa c??n a?aenioie O-oaeia?ieo (?(0,01), ?iaeoeoi?ieo
(?(0,05), noi?ani?ieo (?(0,05) e?ioioeeo?a. Iie?aueeenue iieacieee
?aaoeyoi?ieo i?ioean?a: O-oaeia?ii-noi?ani?iee ?iaeaen cieceany aei
ii?ie, a ?iaeaen CD4/CD8 ca?eueoeany ia 14% (?(0,05), ui na?ae/eei i?i
a?aeiiaeaiiy ??aiiaaae i?ae ?aaoeyoi?ieie oa aoaeoi?ieie O-ee?oeiaie.
A?aenioie aooi?icaoeiooai?thth/eo e?ioioeeo?a oaeiae iiaa?ioany aei
ii?iaeueieo cia/aiue.

I?ney i?eeiio ni??oe?ie ai?no A-e?ioioeeo?a (CD24-iiceoeaieo) o oai?eo
c??n ? aeinya ii?iaeueieo aaee/ei, ii?yae ?c ii?iae?caoe??th e?eueeino?
Ae-ee?oei. Ca?eueoeeinue /enei O- ? A-e?ioioeeo?a ii a?aeiioaiith aei
i?e?iaeieo e?ea??a (?iaeaen CD3+CD24/IE ae??n ia 26%, ?(0,05). I?ney
eo?no e?eoaaiiy c aeei?enoaiiyi ni??oe?ie o oai?eo aeinoia??ii c?inea
eiioeaio?aoe?y ne?iaaoeiaiai IgM (c 0,81(0,07 aei 1,05(0,08, ?(0,05).

Iiina?aaeeiaai? aioei?e?iai? aeanoeaino? ni??oe?ie yne?aa?oa iii?oi? ia
?ioaeoi?e oe???. A oeeo ciiao ia 27% (?(0,05) /ano?oa, i?ae i?ney
aaciaiai e?eoaaiiy, aei ii?ie cieceeinue i?e?iaia canaeaiiy oe??e ? ia
16% (??0,05) — /enei aeiaaee?a aeyaeaiiy a?ai-iaaaoeaieo aaeoa??e.
Iaaeeceeenue aei ii?iaeueieo iieacieee ooaiiai? iaeaaeiino?
noao?eieie?a. Aeuaiacaai? iiceoeai? ci?ie niinoa??aaeenue ? a?ey aiaieu
aecaie, i?ioa ?o ae?aaeai?noue aoea iaioith.

I?e ii?aeiaii? aieeao I?O ? ni??oe?ie a oi?ioe? ia?eoa?e/ii? e?ia?
niinooa??aaeenue iaea?eueo ae?aaeaia c?inoaiiy /enea e?ioioeeo?a ?
cieaeaiiy ?iaeaeno II/E (?(0,05), a?ey aiaieu aecaie iaea?eueo iii?oii
iii?ae on?o a?oi ciaiooaaeanue ?ioiii-caiaeueia ?io?eueo?aoe?y.
E?euee?noue oa ai?no O-ee?oei iii?ae eaeeioeeo?a oa e?ioioeeo?a c?inoaee
?ioaineai?oa, i?ae i?ney AO. Aei ii?ie iaaeeceeanue (?(0,01)
eiioeaio?aoe?y oa ciaioeany a?aenioie aeoeaiaaieo HLA-DR+ O-e?ioioeeo?a.
*enei oaeia?ieo, ?iaeoeoi?ieo e?ioioeeo?a aeinoia??ii c?inei ? aeinyaei
ii?ie, nooo?ai ca?eueoeany oaeiae ?o ai?no (a?aeiia?aeii i?e ?(0,01,
?(0,05). Ii?iae?coaaeenue iieacieee aaniethoii? e?eueeino? oa ai?noo
O-noi?ani??a. A oie aea /an a?aenioie O-oeeoioiene/ieo e?ioioeeo?a o
oai?eo oe??? a?oie ciaiooaaany (?(0,05). Na?ae/aiiyi a?aeiiaeaiiy
aeeiai?/ii? ??aiiaaae i?ae ?aaoeyoi?ieie oa aoaeoi?ieie ee?oeiaie,
aaeuei?aieie oa noeioethth/eie aieeaaie aoea ii?iae?caoe?y
O-oaeia?ii-noi?ani?iiai ?iaeaeno, ?noioia (ia 22%, ?(0,05) c?inoaiiy
?iaeaeno CD4/CD8. sse iane?aeie ?aa?ano aooiaa?aneaiiai eiiiiiaioo
aea?a?/iiai caiaeaiiy i?e IA iiaa?ioany aei ii?ie ai?no
aooi?icaoeiooai?thth/eo O-e?ioioeeo?a. Ciaioeany oaeiae a?aenioie
aeoeaiaaieo (CD150+) A-e?ioioeeo?a (?(0,01), “ioeueiaeo” e?ioioeeo?a
(?(0,05), i?e?iaei?o e?ea??a (?(0.01). Iii?oi?oei, i?ae i?ney AO, aoei
i?aeaeuaiiy ?iaeaen?a O+A/I ? O3+A24/IE . Cia/ii ca?eueoeeanue (?(0,01)
eiioeaio?aoe?y ne?iaaoeiaiai IgM.

?noioii (ia 39% a?ey aiaieu oa 23% ia a?aeaeaeaieo ae?eyieao) cieceeinue
/enei aeiaaee?a nooe?eueiiai ?inoo eieii?e, ? a “i?e?iaiiio
ni?aoiaa?enoa?” aeinoia??ii iaioith noaea ieoiia aaaa noao?eieie?a (ia
32%, ?(0,01) ? a?ai-iaaaoeaieo iaee/eiaeaeieo aaeoa??e (ia 20%,
?(0,05). A?aeaoany ia?a?iciiae?e iioe?aiino? ??cieo ooai?a noao?eieieo:
ye a caei?iaeo ethaeae, oae ? i?ney e?eoaaiiy o oai?eo ia IA aeii?ioaaa
ai?aea?iaeueiee noao?eieie.

Aiae?c ?acoeueoao?a e?eoaaiiy cana?ae/ea, ui canoinoaaiiy a eiiieaeniiio
e?eoaaii? IA ni??oe?ie, I?O oa ?o ii?aeiaia aeei?enoaiiy coiiaeei
i?enei?aiiy ?aa?ano ee?i?/ieo i?iya?a aea?iaoico, iie?auaiiy yeino?
e?eoaaiiy. I?e na?aaei?e o?eaaeino? e?aeeiaeiy i?ney aaciai? oa?ai??
23,00(1,43 aei?, oai??, yeei i?ecia/aee aeiaeaoeiai I?O, cae?i/oaaee
noaoe?iia?ia e?eoaaiiy ia 4-5 aei?a nei??oa, i?ney i?ecia/aiiy ni??oe?ie
– ia 6 aei?a, ?o ii?aeiaiiai i?ecia/aiiy – ia 5-6 aei?a. E?euee?noue
iaoe??io?a, ye? aoee aeienai? a noai? ee?i?/iiai iaeoaeaiiy, i?ney
e?eoaaiiy ?c I?O ia 24%, ?c ni??oe?iith – ia 32%, ?o ii?aeiaiiy – ia 40%
ia?aaeuoaaea aeai? aaciai? a?oie (33% oai?eo). I?ae aieeaii e?eoaaiiy ?c
I?O ? ni??oe?iith naa?a?iiy oe??e cieeaei a na?aaeiueiio ia 3 aei?, ?c
I?O – ia 4 nei??oa, i?ae a aacia?e a?oi?. Oaeiae anoaiiaeaii, ui
canoinoaaiiy a eiiieaeniiio e?eoaaii? I?O coiiaeei ?ai?n?th i?ioyaii
?ieo o 96,2% iaoe??io?a, ni??oe?ie oa ?o ii?aeiaiiy – o an?o
i?ie?eiaaieo (i?ney aaciaiai eiiieaeno oa?ai?? iiaa caaino?aiiy
?icaeioeinue o 22,2% oai?eo).

AENIIAEE

O an?o oai?eo ia i?e?iaio aecaio niinoa??aa?oueny ae?aaeaiee aeenaaeain
?ioiii? a?aeiia?ae? c aieo O-nenoaie ?ioi?oaoo, yeee iiaeia
eeaneo?eoaaoe ye neiae?ii aoi?eiiiai ?ioiiaeao?oeeoo ca O-ee?oeiiei
oeiii.

O oai?eo ia i?e?iaio aecaio aeinoia??ii cieaeaia eiioeaio?aoe?y
ne?iaaoeiaiai ?ioiiaeiaoe?io I, ui ? na?ae/aiiyi iai?oaeaiino? A-nenoaie
?ioi?oaoo.

Aaciina?aaeiuei a?ey aiaieu aecaie, a oaeiae ia a?aeaeaeaieo ae?eyieao
i?ae /an caaino?aiiy i?aeaeuo?oueny e?euee?noue i?e?ii?aai?ci?a ia
iaeeieoeth ieiu?. A neeaae? aeeaiei? aooii?e?ioei?e oe??e ia 15-30%
a?eueoee ai?no caeiathoue a?ai-iaaaoeai? aaeoa??? oa noao?eieiee,
na?aae yeeo aeii?io? cieioenoee ooai.

Ii?yae ?c ?aa?anii aeneiaiue ia oe??? a i?ioean? eiiieaeniiai aaciaiai
e?eoaaiiy a noaoe?iia?ieo oiiaao iieacieee ?ioiieia?/ii? ?aaeoeaiino?
oai?eo ia i?e?iaio aecaio iacia/ii iie?auothoueny. O 62-82% iaoe??io?a
oo?eio?oueny iaaei??ia canaeai?noue oe??e i?e?ii?aai?ciaie, aeii?ioaaiiy
“aa?aneai?oeo” oa iaoa?aeoa?ieo aeey ii?iaeueiiai i?e?ia?ioeaiico
i?e?ii?aai?ci?a. Eeoa o?aoeia oai?eo, ui io?eioaaee aaciao oa?ai?th,
aeienaii c ee?i?/iei iaeoaeaiiyi. Caaino?aiiy aea?iaoico i?ioyaii
ia?oiai ?ieo i?ney e?eoaaiiy niinoa??aaeinue o 22% iaoe??io?a.

I?e?ioaeeueiaa ?aciiainia oa?ai?y ni?ey? ii?iae?caoe?? e?euee?nieo
iieaciee?a ia?eoa?e/ieo e?ioioeeo?a, aaeueio? iaaei??ii aeoeaiaai?
ee?oeiio ? aoii?aeueio eaiee ?ioi?oaoo, i?eai?/o? i?a?aoe?th ee?oei
?ioiiiai caiaeaiiy a ciio aecaiaoicieo aeneiaiue, cieaeo? aeoeai?noue
aooiaa?aneaieo i?ioean?a. O a?eueoi? /anoeie oai?eo ia i?e?iaio aecaio
i?ae aieeaii i?e?ioaeeueiaiai aei?ii?iaiiy ianoa? ii?iae?caoe?y
e?euee?niiai oa ye?niiai noaio aeeaiei? aooii?e?ioei?e. Ia 24%
ca?eueoo?oueny /enei oai?eo ?c iiaiei ?aa?anii ee?i?/ieo iciae, ia 4-5
aei?a nei?i/o?oueny oa?i?i e?eoaaiiy.

?ioiiiiaeoethth/a ae?y ni??oe?ie i?enei?th? a?aeiiaeaiiy e?eueeino?
?ioiieo ?aaoeyoi?ieo ee?oei, aaeueio? iaaei??io aeoeai?noue O- ? A-
ee?oeiieo eaiie, ni?ey? ii?iae?caoe?? iieaciee?a aoii?aeueieo oaeoi??a
?ioi?oaoo. A?ey aiaieu aeneiaiue a?aeiiaeth?oueny aaeain ?ioiieo ?
oaaioeeoa?ieo ee?oei, iie?auothoueny, iniaeeai ia a?aeaeaeaieo
ae?eyieao, iieacieee aooii?e?ioei?e. Aeecueei 65% oai?eo cae?i/othoue
e?eoaaiiy c iiaiei ee?i?/iei aeaeoaeaiiyi, ia 6 aei?a nei?i/o?oueny
oa?i?i e?eoaaiiy.

Ii?aeiaia canoinoaaiiy a eiiieaeni?e oa?ai?? i?aia?aoo ni??oe?ie oa
i?e?ioaeeueiaiai ?aciiainiiai aei?ii?iaiiy i?enei?th? a?aeiiaeaiiy
aaeaino e?ioioeeoa?ieo iiioeyoe?e, aaeueio? aeoeai?noue aoaeoi?ieo
?ioiieo ee?oei, iie?auo? iieacieee aoii?aeueiiai ?ioi?oaoo oa noaio
aooii?e?ioei?e oe??e. Iiaia cieeiaiiy ee?i?/ieo iciae i?e?iaii? aecaie
niinoa??aa?oueny o 73% oai?eo. Ee?i?/ia ?ai?n?y i?ioyaii ?ieo
niinoa??aa?oueny o 96% oai?eo.

I?AEOE*I? ?AEIIAIAeAOe??

O oai?eo ia i?e?iaio aecaio i?e ?ioaineaiiio naa?a?ii? oe??e, iaaei??i?e
aeoeaaoe?? aoaeoi?ii? eaiee ?ioiii? nenoaie, ui a?eueo aeanoeai
iaoe??ioai iieiaeoeo oa na?aaei?o a?eiaeo a?oi, ?aoe?iiaeueii a eiiieaen
e?eoaaiiy aeeth/aoe eo?n i?e?ioaeeueiai? ?aciiainii? oa?ai??: 10-14
uiaeaiieo i?ioeaaeo? ii 10-15 oaeeei ia a?ieia?/ii aeoeai? oi/ee
(?7,?9,GI4,GI11,R7,VB41,VB38,F2) ?c aeiaaeeiith oaee? 7,1 ii (?iai/a
/anoioa 42194 ( 10 IAoe) a ?aaeei? iiaeoeyoe?? /anoioe (40-100IAoe) ?c
u?euei?noth iiooaeiino? aei?ii?iaiiy 10 iAo/ni2.

O oai?eo ia i?e?iaio aecaio ca iayaiino? aeao?oeeoo ii ee?oeiieo
oaeoi?ao ?ioi?oaoo, ui /ano?oa niinoa??aa?oueny o oai?eo iioeeiai oa
noa?a/iai a?eo, ?aoe?iiaeueii a eiiieaenia noaiaea?oia e?eoaaiiy
aeeth/aoe i?aia?ao ni??oe?io: ii 0,5 a o?e ?ace ia aeaiue ca 30 oaeeei
aei ?aee, eo?nii 14-16 aei?a.

O oai?eo ia i?e?iaio aecaio ca iayaiino? ae?aaeaiiai O-e?ioioeeoa?iiai
?ioiiaeao?oeeoo, i?aeaeuaiiai i?e?iaiiai canaeaiiy oe??e, yea
i?iyaey?oueny ?icaeoeii aoi?eiii? i?iaea?i??, ?ioaineaiiai oa o?eaaeiai
naa?a?iiy oe??e ?aoe?iiaeueii a eiiieaenia e?eoaaiiy aeeth/eoe i?aia?ao
ni??oe?io a ii?aeiaii? ?c eo?nii i?e?ioaeeueiai? ?aciiainii? oa?ai??
ca?aeii iaoiaeee, iienaieo a ioieoao 1-2.

Ia?ae?e ?ia?o, iioae?eiaaieo ca iaoa??aeaie aeena?oaoe??

Aeaenaiae?oe I.Ae. I?i no/ani? aeai? a na?oe? iaoiaaiaco i?e?iaii?
aecaie // Aaeeoeueeee e?ea?nueeee a?niee.- 1995.-O.2,/enei 3-4.-N.56-58.

Aeaenaiae?oe I.Ae. No/ani? iiaeyaee ia iaoiaaiac i?e?iaii? aecaie.
I?e?iaiee oaeoi? // Aaeeoeueeee e?ea?nueeee a?niee.-
1997.-O.4,/enei3.-N.107-108.

Aeaenaiae?oe I.Ae. Aieea ni??oe?ie a eiiieaeniiio e?eoaaii? ia iieacieee
?ioi?oaoo o oai?eo i?e?iaiith aecaiith // Aaeeoeueeee e?ea?nueeee
a?niee.- 1998.-O.5,/enei2.-N.7-9.

Aeaenaiae?oe I.Ae. Noao?eieiee oa i?e?iaia aecaia: iia? aniaeoe
iaoiaaiaco//Aaeeoeueeee e?ea?nueeee a?niee.- 1998.-O.5,/enei3.-N.7-8.

Oea/ A.?., Aeaenaiae?oe I.Ae. Aea/aiiy aooioei?e oe??e iiaeeo?eiaaiei
iaie iaoiaeii a?aeaeoe?a i?e aea?iaoicao // ?a?no? iaaeeei-a?ieia?/ieo
iiaiaaaaeaiue o i?aeoeeo ioi?iie
caei?ia’y.-?aaii-O?aie?anuee.-1998.-N.62.

Oea/ A.?., Aeaenaiae?oe I.Ae. Eiiieaenia aecia/aiiy i?eeeiath/eo ee?oei,
iiaeeiaeueii? caeaoiino? iie?ioeeaa??a oa i?iaaaeaiiy INO oanoo a
i?e?iaeicao ia?eoa?e/ii? e?ia? // ?a?no? iaaeeei-a?ieia?/ieo
iiaiaaaaeaiue o i?aeoeeo ioi?iie
caei?ia’y.-?aaii-O?aie?anuee.-1998.-N.64.

Aeaenaiae?oe I.Ae. Eiiieaeni? i?aia?aoe a oa?ai?? i?e?iaii?
ia?ao?aaiaoe/ii? aecaie // Aeooaeueiua aii?inu aea?iaoiaaia?ieiaee
(Iao/ii-i?aeoe/aneee nai?iee noaoae). Aui. 10.
Aeiai?iiao?iane-Oiaeueieoeeee, 1997.- N.117.

Aeaenaiae?oe I.Ae. Aieea ia ?ioiiee noaoon oai?eo i?e?iaiith aecaiith
eiiieaeniiai e?eoaaiiy c aeei?enoaiiyi ni??oe?ie oa I?O // Iaoa??aee ??
c’?caeo ooec?ao??a ? ioeueiiiieia?a Oe?a?ie.- Ee?a.- 1998.- N.209.

Aeaenaiae?oe I.Ae. Aeni?an?y aioeaai?a aeeoa?aioe?thaaiiy ee?oeiaie
e?ia? o oai?eo i?e?iaiith aecaiith a i?ioean? aaciai? oa?ai?? //
Iaoa??aee XIV c’?caeo oa?aiaao?a Oe?a?ie.- Ee?a.- 1998.- N.523-524.

Aeaenaiae?oe I.Ae. Aeaye? aeai? i?i i?e?ioei?o iiaa?oi? oe??e o oai?eo
i?e?iaiith aecaiith // Oace aeiiia?aeae 65-? eiioa?aioe??
nooaeaionueeiai iaoeiaiai oiaa?enoaa. – ?aaii-O?aie?anuee. – 1996. –
N.10.

Ea??i N.E., Aeaenaiae?oe I.Ae. Aiae?c aeaieo i?i noai aoii?aeueieo
oaeoi??a ?ioi?oaoo o oai?eo aecaiith // Oace aeiiia?aeae 65-?
eiioa?aioe?? nooaeaionueeiai iaoeiaiai oiaa?enoaa. – ?aaii-O?aie?anuee.
– 1996. – N.33.

Aiiioaoeey

Aeaenaiae?oe A.Ae. Eiiieaeniia ea/aiea iee?iaiie yecaiu n
eniieueciaaieai iee?iaieiiaie ?aciiainiie oa?aiee e nie?oeeiu
(eeeie/aneia enneaaeiaaiea) – ?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.01.20 – “Eiaeiua e aaia?e/aneea aieacie”. –
Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. A.A.Aiaiiieueoea, Eeaa,
1999.

I?aaenoaaeaiiay e caueoa aeenna?oaoeey ia i?aaao ?oeiiene inaauaao
ia?ooaiea eeaoi/iiai e aoii?aeueiiai caaiueaa eiioiieiae/aneie
?aaeoeaiinoe, ninoiyiea aeoaieie aooiiee?ioei?u eiaee o aieueiuo
iee?iaiie yecaiie, ei??aeoeeth iaia?oaeaiiuo eciaiaiee a i?ioeanna
i?aaeeaaaaiiai eiiieaeniiai ea/aiey n eniieueciaaieai iee?iaieiiaie
?aciiainiie oa?aiee, nie?oeeiu e eo ni/aoaiiiai i?eiaiaiey.

I?e eco/aiee eiioiiiai noaoona aieueiuo enneaaeiaaee eeioioeeoa?iua
iiioeyoeee e noaiiioeyoeee iaoiaeii eiioiioaiioeie?iaaiey n
eniieueciaaieai iiiieeiiaeueiuo aioeoae e eeaoi/iui ?aoeaioi?ai CD3,
CD4, CD8, CD24, CD56 (“Sigma”, NOA) e ioa/anoaaiiuo na?ee EII3, EII47;
ia?aeeaeueii noaaeee ?aaeoeee ?icaoeiia?aciaaiey aeey ii?aaeaeaiey
niaea?aeaiey O-, O-oaeia?iuo, O-noi?anni?iuo, O-aeoeaiuo,
O-aooi?icaoeiia?acothueo, A-, Ae- e “ioeaauo” eeoioeeoia; iieacaoaee
nuai?ioi/iiai eecioeeia enneaaeiaaee ii iaoiaeo I.A.Aooa?eia,
eiioeaio?aoeeth eiioiiaeiaoeeiia nuai?ioee e?iae iaoiaeii ?aaeeaeueiie
eiioiiaeeooocee ii G.Mancini, oee?eoee?othueo eiioiiuo eiiieaenia ii
O.E.Aaoeiaie; ninoiyiea aeoaieie aooiiee?ioei?u eiaee eco/aee ii iaoiaeo
i/aaiauo ioia/aoeia I.I. Eeaiia?neie; eaeaioeoeoee?iaaee aeaeiaoth
i?eiaaeeaaeiinoue noaoeeieieia.

I?iaaae?iiuie enneaaeiaaieyie o aieueiuo iee?iaiie yecaiie eco/aii
ninoiyiea eiioiiie ?aaeoeaiinoe e aooiiee?ioei?u eiaee ai a?aiy
iaino?aiey aea?iaoica, aeeiaieea iieacaoaeae iiae aeeyieai
o?aaeeoeeiiiiai eiiieaeniiai ea/aiey. Onoaiiaeaii, /oi i?e iinooieaiee a
noaoeeiia? o aieueiuo iee?iaiie yecaiie iaaethaeaaony O-eeaoi/iue
eiioiiaeaoeoeeo ?aciie noaiaie au?aaeaiiinoe, /?acia?iia iee?iaiia
canaeaiea iia?aaeae?iiie e eioaeoiie eiaee n i?aiaeaaeaieai
noaoeeieieeiaie e a?aiio?eoeaoaeueiie iaei/eiaeaeiie oei?u. Iiae
aeeyieai aaciaiai eiiieaeniiai ea/aiey ia iiiaio auienee aieueiuo ec
noaoeeiia?a aieueoeinoai iieacaoaeae eiioieoaoa e aooiiee?ioei?u eiaee
ia aica?auathony e ii?ia.

Onoaiiaeaii, /oi eniieueciaaiea iee?iaieiiaie ?aciiainiie oa?aiee,
nie?oeeiu e eo ni/aoaiey aneaaenoaea eiioiiiiaeoee?othuaai aeeyiey
nii?iaiaeaeaaony aeinoiaa?iui oeo/oaieai iieacaoaeae eeaoi/iiai e
aoii?aeueiiai eiioieoaoa: iiauoaieai a aaiioee?eoeyoeee aei ii?iaeueiuo
aaee/ei eiee/anoaa eeioioeeoa?iuo iiioeyoeee e noaiiioeyoeee, nieaeaieai
eo /?acia?iie aeoeaiinoe e iea?aoeee e i/aaai aunuiaiee. Iiae aeeyieai
i?aaeeiaeaiiuo noai oa?aiee e ii?iaeueiui iieacaoaeyi ea/anoaaiiiai e
eiee/anoaaiiiai ninoaaa aica?auaaony aeoaieay aooiiee?ioei?a eiaee.
Iiauoaaony ea/anoai noaoeeiia?iiai ea/aiey aieueiuo iee?iaiie yecaiie,
oiaiueoaaony aai aeeeoaeueiinoue. Iaania/eaaaony noieeinoue eeeie/aneie
?aiennee ia i?ioyaeaiee aiaea.

Ii iaoa?eaeai aeenna?oaoeee ?ac?aaioaiu iaoiaeeee eiiieaeniiai ea/aiey
aieueiuo iee?iaiie yecaiie n eniieueciaaieai iee?iaieiiaie ?aciiainiie
oa?aiee, nie?oeeiu e eo ni/aoaiey.

Eeth/aaua neiaa: iee?iaiay yecaia, iee?iaieiiaay ?aciiainiay oa?aiey,
nie?oeeia, eiioiiay nenoaia, aooiiee?ioei?a.

Aiioaoe?y

Aeaenaiae?oe I.Ae. Eiiieaenia e?eoaaiiy i?e?iaii? aecaie ?c
aeei?enoaiiyi iee?ioaeeueiai? ?aciiainii? oa?ai?? oa ni??oe?ie (ee?i?/ia
aeine?aeaeaiiy) – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ii niaoeeaeueiino? 14.01.20 – oe??i? oa aaia?e/i? oai?iae. –
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey, Ee?a, 1999.

Aeena?oaoe?y i?enay/aia ieoaiith aea/aiiy ii?ooaiue ee?oeiii? oa
aoii?aeueii? eaiie ?ioiieia?/ii? ?aaeoeaiino?, noaio aooii?e?ioei?e
oe??e o oai?eo ia i?e?iaio aecaio, a oaeiae aeeiai?ee iieaciee?a i?ae
aieeaii o?aaee?eiiai eiiieaeniiai e?eoaaiiy. Aeiaaaeaii aeioe?euei?noue
canoinoaaiiy a eiiieaen? e?eoaaiiy oai?eo ia i?e?iaio aecaio
i?e?ioaeeueiai? ?aciiainii? oa?ai??, ni??oe?ie oa ?o ii?aeiaiiy, ui
ni?ey? iie?auaiith aoaeoeaiino? e?eoaaiiy, nei?i/aiith eiai oa?i?i?a,
ii?iae?caoe?? iieaciee?a ?ioi?oaoo oa aooii?e?ioei?e oe??e a a?eueo
?aii? oa?i?ie.

Eeth/ia? neiaa: i?e?iaia aecaia, i?e?ioaeeueiaa ?aciiainia oa?ai?y,
ni??oe?ia, ?ioiia nenoaia, aooii?e?ioei?a.

Abstract

Alexandruk O.D. The complex treatment of patients suffering from
microbial eczema with microwave resonance therapy and Spirulina
(clinical study). – Manuscript.

Thesis for the degree of Candidate of Medical science in speciality
14.01.20 – Skin and Venereal diseases. – A.A.Bogomolets National medical
university, Kyiv, 1999.

The dissertation is devoted to the problems of cellular and humoral
immunity, skin microflora in patients with microbial eczema and changes
that take place under traditional complex treatment. It was illuminated
and proved that additional prescribtion of microwave resonance therapy
and Spirulina in the complex treatment of eczema patients helps to
increase treatment effectiveness, shortener its terms and normalise
immune and skin microflora data. It prolonges remission period in
patients with eczema and has no side effects.

Key words: microbial eczema, microwave resonance therapy, Spirulina,
immune system, automicroflora.

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