I?I?NOA?NOAI IOI?IIE CAeI?IA‘ss OE?A?IE

IAeANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Iaethe A?eoi? A?eoi?iae/

OAeE: 616-085:618.12-002:615.326

EIIIEAENIA OA?AI?ss

O?II?*IEO CAIAEUeIEO CAOAI?THAAIUe

AeIAeAOE?A IAOEE

?C CANOINOAAIIssI IA?AIIE?I?AEO

(aenia?eiaioaeueii-ee?i?/ia aeine?aeaeaiiy)

14.01.01 — aeooa?noai oa a?iaeieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iaeana – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaeanueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

I?i?noa?noaa ioi?iie caei?ia‘y Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Cae?inueeee Ieaenaiae? Ieaen?eiae/,

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e ia?eiaoaeueii? iaaeeoeeie,

aeeoy/i? oa i?aee?oeiai? a?iaeieia??

Iaoeiaee eiinoeueoaio: aeieoi? iaaee/ieo iaoe, noa?oee

iaoeiaee ni?a?ia?oiee

Nioi?eiaa Ieaia Iao??aia,

?inoeooo i/ieo oai?ia ? oeaieiii? oa?ai??

?i. A.I. O?eaoiaa AII Oe?a?ie,

caa. eaai?aoi??? oa?iaeieia??

oeaieiieo i?aia?ao?a

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Nieuenueeee sse?a Ii?oe??eiae/,

?inoeooo IAA AII Oe?a?ie,

caa?aeoaa/ a?aeae?eaiiy a?iaeieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

Aaaei?a TH??e ?aaiiae/,

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e ee?i?/ii? ?ioiieia??,

aaiaoeee oa iaaee/ii? a?ieia??

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. aeaae. I.I. Aiaiiieueoey IIC Oe?a?ie,

eaoaae?a aeooa?noaa oa a?iaeieia?? ?3

Caoeno a?aeaoaeaoueny “25_” _a?oaeiy____ 1998 ?ieo i _15__ aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.600.01 i?e Iaeanueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (270026, i. Iaeana, i?ia.
Aae?oianueeee, 2).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (270026, i. Iaeana, i?ia.
Aae?oianueeee, 3).

Aaoi?aoa?ao ?ic?neaiee “_23_” _eenoiiaaea__ 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiae.iaae.iaoe, aeioeaio ?iaeeianueea I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia caiaeueieo caoai?thaaiue ae?ii/eo noaoaaeo
i?aai?a i?iaeiaaeo? caeeoaoeny iaei??th c naieo aeooaeueieo ye o
ee?i?/iiio, oae ? a iaoeiaiio ieai?, ? ia? aaeeea nioe?aeueia cia/aiiy,
ianaiia?aae aecia/ath/e aeaiia?ao?/io neooaoe?th a Oe?a?i?. O?ii?/i?
caiaeuei? i?ioeane aeiaeaoe?a iaoee (OCIAeI) caeiathoue aaaeo/a i?noea o
no?oeoo?? a?iaeieia?/ii? caoai?thaaiino? ? neeaaeathoue 28-71% a?ae ??
caaaeueiiai ??aiy, aoaeo/e iaei??th ?c aieiaieo i?e/ei ii?ooaiue
niaoeeo?/ieo ooieoe?e ae?ii/iai i?aai?cio ?, a ia?oo /a?ao,
?ai?iaeoeoeaii? ooieoe?? (Aieoaaa A.A, 1986; Nieueneee ss.I., Eaaithoa
E.E., 1988; Aeeaiacyi Y.E., 1991; Eoeaeia A.E, Aeoeyaaa A.I., 1995;
A?euaiei A.E., 1995; Aeoainna?neay C.I. e niaao., 1996; Iaci?/oe A.O.,
1997; Jaffe R.B., 1991; Carr B.R., 1992).

Ia aeeaey/enue ia aeineoue cia/io e?euee?noue ioae?eaoe?e, i?enay/aieo
ieoaiiyi ?ic?iaee cania?a e?eoaaiiy o?ii?/ieo naeuei?iaiioi?eo?a
(Aiaeyaeeia A. E., 1990; Aeoainna?neay C.I., 1989; Ia?e?i E.A.,
Ieoaeeaiei I.O., 1994; Hemsell D.L., Heard B.G., 1993), aoaeoeai?noue ?o
caeeoa?oueny ii??aiyii ia aenieith ? ia aaaea aei ciaioaiiy aeaii?
eaoaai??? oai?eo oa /anoioe ?aoeeaeea?a caiaeueieo i?ioean?a aeiaeaoe?a
iaoee.

Iaaia no?ee?noue o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a iaoee aei
?yaeo oa?aiaaoe/ieo eiiieaen?a i?eaaea aei iiyae aeayeeo iiaeo ee?i?/ieo
oi?i caoai?thaaiiy, na?aae yeeo cia/io ieoiio aaao caeia? o?eaaea
a,yeioaeo/a oi?ia, c /anoeie caaino?aiiyie caoai?thaaiiy oa c
?oaoeaai-nia?/iei i?ioeanii o?ii?/iiai ia?aa?ao (Aeoainna?neay C.I.,
1995; Kneshn A.J., Setter D.B., 1994).

Aeeiiai? aeine?aeaeaiiy ii aea/aiith iaoiaaiaco o?ii?/iiai
naeuei?iaiioi?eoo (Eaooiai I.ss., Iiaecieeiaa I.I., 1993; Ao?oiaie A.E.,
Eoeaeia A.E., 1996) caniiaai?, a oe?eiio, ia aeaieo ca ?ioaa?aeueiith
ioe?ieith o?ii?/iiai caiaeueiiai i?ioeano ? ia caaaeaee iiaeooue
a?aeaeaaoe ?iaeea?aeoaeueio oa?aeoa?enoeeo caoai?thaaiiy. Aeayeeie
aeine?aeieeaie iieacaii, ui i?e o?ii?/iiio naeuei?iaiioi?eo? c? no?eeei
aieth/ei neiae?iiii, ia?aeiiiio o?ii?/iiio caoai?thaaii?, o?ii?/iiio
?aoeeaeeaoth/iio aaeiaeneo? niinoa??aathoueny ??ciiiai?oi? oeie
a?iioaeaii-oe?ai?aeii? ?aaoeyoe??, ui aieeaa? ia ia?aa?a oa o?ii?caoe?th
caiaeueiiai i?ioeano (?aaithoa E.?., 1996; A?ae E.I., 1996; Horsky I.,
1989).

Iiaeeeai, c oeei ? iia’ycaia oa, ui aeei?enoaiiy iaa?oue iiaeo cania?a
oa?ai?? oe??? iaoieia??, a oe?eiio, ? iaei aai iacia/ii aoaeoeaiei. A
oa?aiaaoe/iiio aoaeo? OCIAeI aaeeea cia/aiiy ia? aeo?aeiee noai
?ioiieia?/ii? ?aaeoeaiino? i?aai?cio (Aiae ?.A., 1989; Eiia?ia A.E.,
1993;

?icoiee ?.?., 1997; Abraham G.E., Klaiber E.L., 1993). sseui ia aeaiee
ia??iae /ano aeinoaoiuei oe?iei aea/aii noai e?ioioeeoa?ii? eaiee
o?ii?/ieo aaeiaeneo?a (Iiaecieeiaa I.I., 1993), oi aea/aiiy noaio
ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio i?iaaaeaii eeoa a iiiaeeiieeo
aeine?aeaeaiiyo (O?ai/oe A.A., 1985).

Ia?niaeoeai?noue ?ic?iaie i?aia?ao?a a?iaaiiiai iioiaeaeaiiy, ye? ?ai?oa
oe?iei aeei?enoiaoaaeenue o eiiieaeni?e oa?ai?? caiaeueieo i?ioean?a
aeiaeaoe?a iaoee, aecia/aeanue ?o ni?iiiaei?noth iineethaaoe caoeni? oa
i?enoinoaaeuei? (aaeaioaoe?ei?) noaie ??ciiiai?oieo nenoai i?aai?cio
(Aeaaoy?aiei O. A., Iaeoeueeei ?.O., 1997; Nioieeiaa A.I., 1992;
Ieaa?ine?n A.I., 1994). Iaeiae aeine?aeaeaiiy ii aenia?eiaioaeueiiio oa
ee?i?/iiio iaa?oiooaaiith iiaeeeaiai aeei?enoaiiy aeayeeo iiaeo
i?aia?ao?a i?e?iaeiiai iioiaeaeaiiy a a?iaeieia?/i?e i?aeoeoe? inoaii?
25 ?ie?a ia i?iaiaeeeeny.

Aei /enea iiaeo i?aia?ao?a ?c a?oie a?iaaiieo noeioeyoi??a, ?ic?iaeaieo
a inoaii? ?iee, a?aeiineoueny i?aia?ao aaii?aai?/ii? i?e?iaee –
ia?aiie?i?ae. A?i yaey? niaith i?e?iaeiee eiiieaen iaoaaie?o?a o
aeaeyae? iaoaeii?aai?/ieo niieoe, nieae i?e?iaeaiaio?a ? i?aai?/ieo
?a/iaei (Nieiaueaaa A.I., Nioieeiaa A.I., Eioio O.Ae., 1993). Aeiaaaeaii
eiai aenieo aoaeoeai?noue o oa?ai?? ??ciiiai?oieo iooaeueiieia?/ieo
caoai?thaaiue (Naaei A.A., Ia??oeeia I.I., 1996; Eiaae E.I., 1996),
ooaa?eoeueico eaaaiue (Aaao??ia I.A., 1997), caoai?thaaiiyo noaeei
(Na?aaaaa I.TH., 1995), o iaa?ieia?/i?e i?aeoeoe? (Eo?aei TH.E., 1995,
1996) oa aa??ao??? (Eoi?ao E.I., 1995).

Oaeei /eiii, aea/aiiy iniaeeainoae iaoiaaiaco ?yaeo ee?i?/ieo oi?i
o?ii?/iiai naeuei?iaiioi?eoo ia i?aenoaa? aeaieo i?i noai ianiaoeeo?/ii?
?acenoaioiino? i?aai?cio, a?iioaeaii-a?iio?ca?ii-y?/ieeiai?,
a?iioaeaii-oe?ai?aeii?, a?iio?ca?ii-iaaeie?eiai? ?aaoeyoe?? iiaea aooe
iniiaith aeey aecia/aiiy oeo eaoaai??e ae?iie, ui no?aaeaeathoue
o?ii?/ieie caiaeueieie caoai?thaaiiyie aeiaeaoe?a iaoee, o yeeo
canoinoaaiiy ia?aiie?i?aeo ? oe?eeii ii?aaaeaiei aeey eiai aeeth/aiiy a
eiiieaenio oa?ai?th aeaii? iaoieia?? noaoaaeo i?aai?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeaia ?iaioa ?
o?aaiaioii iaoeiaeo oai, caoaa?aeaeaieo I?i?noa?noaii ioi?iie caei?ia’y
Oe?a?ie, ye i??i?eoaoi? iaoeia? aeine?aeaeaiiy: 1. “Iaoiaaiaoe/i?
iaoai?cie oi?ioaaiiy oaoiieaoeaioa?ii? iaaeinoaoiino? ? ieoaiiy ??
i?io?eaeoeee”, ? aea?aeaaii? ?a?no?aoe?? — 0195 U 022689; 2. “Aea/aiiy
aieeao aaaeeeo iaoae?a ia oi?ioaaiiy o?ii?/ii? oaoiieaoeaioa?ii?
iaaeinoaoiino? ? ?ic?iaea e?eoaaeueii-i?io?eaeoe/ieo caoiae?a”, ?
aea?aeaaii? ?a?no?aoe?? — 0194 U 095698.

Iaoa ?iaioe. I?aeaeueoe aoaeoeai?noue eiiieaenii? oa?ai?? o?ii?/ieo
caiaeueieo caoai?thaaiue aeiaeaoe?a iaoee oeyoii canoinoaaiiy iiaiai
i?aia?aoo a?iaaiii? i?e?iaee – ia?aiie?i?aeo.

Iniiai? caaaeaiiy aeine?aeaeaiiy:

1. A aenia?eiaioaeueieo oiiaao aea/eoe aieea ia?aiie?i?aeo ia noai
?ioiieia?/ii? ?aaeoeaiino? i?aai?cio o i?aeaeine?aeieo oaa?ei.

2. Aea/eoe noai a?iioaeaii-a?iio?ca?ii-y?/ieeiai?,
a?iio?ca?ii-oe?ai?aeii? ?aaoeyoe?? o ae?iie c ??ciiiai?oieie ee?i?/ieie
oi?iaie ia?aa?ao caiaeueieo caoai?thaaiue.

3. Aea/eoe noai ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio i?e
??ciiiai?oieo ee?i?/ieo oi?iao ia?aa?ao caoai?thaaiiy.

4. Aea/eoe ee?i?/io aoaeoeai?noue eiiieaenii? oa?ai?? ?c canoinoaaiiyi
ia?aiie?i?aeo o oai?eo c /anoeie ?aoeeaeeaaie caiaeueiiai i?ioeano, c
o?eaaeei a‘yeioaeo/ei ia?aa?aii, c ?oaoeaai-nia?/iei i?ioeanii oa ??
aieea ia noai aiaeie?eiii? ?aaoeyoe??, ooieoe?th y?/iee?a oa
ianiaoeeo?/io ?acenoaioi?noue i?aai?cio.

5. I?iaanoe ii??aiyeueiee aiae?c aoaeoeaiino? eiiieaenii? oa?ai?? ?c
canoinoaaiiyi ia?aiie?i?aeo o oai?eo c OCIAeI i?e nae?i-aaaeii?iaeueiiio
oa ia?aioa?aeueiiio oeyoao aaaaeaiiy i?aia?aoo.

6. Ai?iaaaeeoe a e?eoaaeueio i?aeoeeo iiaee can?a e?eoaaiiy OCIAeI ?c
canoinoaaiiyi i?aia?aoo aaii?aai?/ii? i?e?iaee – ia?aiie?i?aeo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa anoaiiaeaii, ui
ia?aiie?i?ae aieiae?? ?ioiiiiaeoethth/ei aieeaii ia aoii?aeueio eaieo
?ioi?oaoo, aoaeoeai?noue yeiai caeaaeeoue a?ae aeo?aeiiai ??aiy
aoii?aeueii? eaiee.

Aia?oa anoaiiaeaii, ui ia?aiie?i?ae ni?ey? i?aeaeuaiith
ooieoe?iiaeueiiai noaio eaeeioeeo?a oeyoii i?aeneeaiiy oaaioeeoa?ii?
aeoeaiino?, ui aeinyaa? naiai iaeaeuiai ??aiy ia 14-21 aeaiue
canoinoaaiiy i?aia?aoo.

Aia?oa anoaiiaeaii, ui o ae?iie c ??cieie ee?i?/ieie oi?iaie ia?aa?ao
o?ii?/iiai caiaeueiiai i?ioeano niinoa??aathoueny ??ci? noaie
ianiaoeeo?/ii? ?acenoaioiino?. I?e oeueiio iaea?eueo cieaeaiith aiia ? o
oai?eo c o?eaaeei a‘yeioaeo/ei i?ioeanii aai c /anoeie caaino?aiiyie
caiaeaiiy. O oai?eo c o?ii?/iei ?oaoeaai-nia?/iei i?ioeanii aeiaeaoe?a
iaoee iieacieee, ui oa?aeoa?ecothoue noai ianiaoeeo?/ii? ?acenoaioiino?
i?aai?cio iaeaea ia ci?iththoueny.

Iieacaii, ui i?e ??cieo ee?i?/ieo oi?iao ia?aa?ao caoai?thaaiiy iathoue
i?noea iieacieee, ui ?ic??ciythoueny ??aiai ai?iii?a, a?aecia/ath/e o?
aai ?io? ??ai? ai?iiiaeueii? ?aaoeyoe?? ooieoe?? y?/iee?a, na?aae yeeo
iae/ano?oeie ? a?aeiinia a?ia?i?ieaeoeiai?y, a?aeiini? a?iioe?ai?aei? oa
a?ia?oe?ai?aei? oeie ?aaoeyoe??.

Aoaeoeai?noue oa?aiaaoe/iiai aieeao eiiieaenii? oa?ai?? ?c canoinoaaiiyi
ia?aiie?i?aeo o oai?eo c OCIAeI caeaaeeoue a?ae aeo?aeiiai noaio
ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio oa ?o ai?iiiaeueiiai aaeaino.

Io?eiaii iiceoeaia ??oaiiy ia aeaeaaaiiy iaoaioo Oe?a?ie “Can?a
e?eoaaiiy o?ii?/ieo caiaeueieo caoai?thaaiue aeiaeaoe?a iaoee” ca
cayaith ?98002135.

Aecia/aii, ui iie?ii?oiiyaea?i? eaeeioeeoe (IssE) ? iaei??th c aaaeo/eo
eaiie oi?ioaaiiy nenoaie ?ioiieia?/ii? ?aaeoeaiino? o oai?eo c OCIAeI.
I?e ??ciiiai?oieo ee?i?/ieo oi?iao ia?aa?ao caoai?thaaiiy
niinoa??aa?oueny oa aai ?ioa oa?iaioaoeaia aeoeai?noue eenei? oinoaoace
(EO), ia?ieneaeace (II), neeaae eao?iiieo a?ee?a (EA). Iaea?eueoa
cieaeaiiy oa?iaioaoeaii? aeoeaiino? IssE ia? i?noea o ae?iie c o?eaaeei
a‘yeioaeo/ei o?ii?/iei naeuei?iaiioi?eoii ? o ae?iie c /anoeie
caaino?aiiyie i?ioeano.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aecia/aia /?oea
caeaaei?noue oeo aai ?ioeo noai?a a?iio?ca?ii-y?/ieeiai? ?
a?iio?ca?ii-oe?ai?aeii? ?aaoeyoe?? a?ae ee?i?/ii? oi?ie ia?aa?ao
o?ii?/iiai caiaeueiiai i?ioeano, ui ? i?aeoe/ii iaiao?aeiei aeey
?ic?iaee oa i?iaaaeaiiy eiiieaenii? oa?ai?? aeaiiai caoai?thaaiiy.

Iieacieee NOeE EO, II, EA oa niiioaiiiai ? “noeioeueiaaiiai” NBT-oanoo
iiaeooue aooe aeei?enoai? ye e?eoa??? ooieoe?iiaeueiiai noaio IssE oa
aecia/aoe ?ioaineai?noue ? o?eaae?noue oa?aiaaoe/iiai eiiieaeno ?c
canoinoaaiiyi ia?aiie?i?aeo.

Aeey i?aeaeuaiiy aoaeoeaiino? eiiieaenii? oa?ai?? OCIAeI ?aoe?iiaeueiei
? aeeth/aiiy aei ?? neeaaeo ia?aiie?i?aeo ye a?inoeioeyoi?a oa
aaeaioiaaia.

Canoinoaaiiy cai?iiiiiaaiiai caniao eiiieaenii? oa?ai?? cia/ii iie?auo?
noai oai?eo o a?eueoino? iaoe??io?a oa ni?ey? ?aa?ano ee?i?/ieo i?iya?a
caiaeueiiai i?ioeano. Aoaeoeai?noue oa?ai?? cia/ii ca?eueoo?oueny i?e
i?iaaaeaii? 2-3 eo?n?a e?eoaaiiy.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii i?iaaaeaii iiooe, aiae?c
e?oa?aoo?e ii oai? aeine?aeaeaiiy, caa?? iaoa??aeo aeey i?iaaaeaiiy
a?io?i?/ieo, ?aae?i?ioiieia?/ieo oa ?ioiioa?iaioieo aeine?aeaeaiue.
Naiino?eii aeeiiaii ?yae aeine?aeaeaiue ii aea/aiith ooieoe?iiaeueiiai
noaio IssE e?ia?, ?ioa?i?aoaoe?th ai?iiiaeueieo ? ?ioiieia?/ieo
aeine?aeaeaiue, ?o noaoenoe/io ia?iaeo. I?iaaaeaii e?eoaaiiy i?io?eueieo
oai?eo. Aenia?eiaioaeuei? aeine?aeaeaiiy aeeiiai? ia aac? eaai?aoi???
oa?iaeieia?? oeaieiieo i?aia?ao?a ?inoeoooo i/ieo oai?ia ? oeaieiii?
oa?ai?? ?i. A.I. O?eaoiaa AII Oe?a?ie. ?ioiieia?/i? aniaeoe ?iaioe
i?ieiinoeueoiaai? aeieoi?ii iaaee/ieo iaoe Aeaaoy?aiei O.A.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Aeena?oaoe?y ai?iaiaaia ia
?icoe?aiiio can?aeaii? eaoaae?e ia?eiaoieia??, aeeoy/i? oa i?aee?oeiai?
a?iaeieia?? ni?eueii c ?aaeith ee?i?/iiai iieiaiaiai aoaeeieo ?5 i.
Iaeane oa iaeaniiai ia?eiaoaeueiiai oeaio?o i. Ieeiea?aa. Iniiai?
iieiaeaiiy aeena?oaoe?? aeeeaaeai? ia II iaoeiai-i?aeoe/i?e eiioa?aioe??
aeeoy/i? oa i?aee?oeiai? a?iaeieia?? (Iaeana, 1995), O c’?cae?
aeooa??a-a?iaeieia?a Oe?a?ie (Iaeana, 1996), can?aeaii?
iaoeiai-i?aeoe/iiai oiaa?enoaa aeooa??a-a?iaeieia?a Ieeiea?anueei?
iaeano? (Ieeiea?a, 1996, 1997), can?aeaii? Ieeiea?anueeiai a?aeae?eaiiy
Anioe?aoe?? aeooa??a-a?iaeieia?a Oe?a?ie (Ieeiea?a, 1998) oa
I?aeia?iaei?e ee?i?/i?e iaoeiai-i?aeoe/i?e eiioa?aioe?? ii oeaieii?e
oa?ai?? (Iaeana, 1998).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 8 iaoeiaeo i?aoeue, c
ieo 3 ?iaioe a i?io?eueieo iaaee/ieo aeo?iaeao.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 187
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iieno iaoiae?a aeine?aeaeaiue, i‘yoe ?icae?e?a aeanieo
niinoa?aaeaiue, aiae?co oa ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiue,
aeniiae?a ? i?aeoe/ieo ?aeiiaiaeaoe?e. ?iaioa ?ethno?iaaia 11 ?enoieaie,
53 oaaeeoeyie. A?ae?ia?ao?y neeaaea? 30 noi??iie — 333 ?iaioe, ?c ieo
206 a?o/eciyieo ? 127 ca?oa?aeieo.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Anueiai ianoaaeaii 167 ae?iie ?c
caiaeueieie caoai?thaaiiyie aeiaeaoe?a iaoee (a?eiaee oeaic ianoaaeaieo
ae?iie aoa a?ae 21 aei 39 ?ie?a), ye? aoee ?iciiae?eai? ia 3 a?oie:
ia?oo neeaee 63 ae?iee, ye? io?eioaaee eiiieaenio oa?ai?th ?c
canoinoaaiiyi ia?aiie?i?aeo ia?aioa?aeueii ii 2 ie, uiaeiy c 5 ii 25-27
aeaiue oeeeeo; ae?oao — 59 ae?iie, yeei ia?aiie?i?ae aaiaeeany ca
aeiiiiiaith nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco ia oii? eiiieaenii?
oa?ai?? ? o?aoth — 45 ae?iie (eiio?ieueia a?oia).

O caeaaeiino? a?ae ee?i?/ii? oi?ie caoai?thaaiiy aoee noi?iiaai? 3
i?aea?oie: c /anoeie caaino?aiiyie i?ioeano — 56 (33,5%), c o?eaaeei
a‘yeioaeo/ei ia?aa?aii — 72 (43,1%) ? c iayai?noth ?oaoeaai-nia?/iiai
i?ioeano — 39 (23,4%) ae?iie. O eiaei?e ?c ieo ?acoeueoaoe
aeine?aeaeaiue ? e?eoaaiiy aiae?coaaeenue o caeaaeiino? a?ae ee?i?/ii?
oi?ie oa o?eaaeino? ia?aa?ao caoai?thaaiiy: aei 3 ?ie?a, aei 5 ?ie?a oa
iiiaae 5 ?ie?a — anueiai, a?aeiia?aeii o 64 (38,3%), 63 (37,7%) ? 40
(24%) ae?iie.

Iaa?oiooaaiiyi aeey ee?i?/iiai canoinoaaiiy ia?aiie?i?aeo a oa?ai??
oai?eo OCIAeI noaee ?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue, ui
aoee aeeiiai? a oa?iaeieia?/i?e eaai?aoi??? oeaieiieo i?aia?ao?a
?inoeoooo i/ieo oai?ia oa oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa AII
Oe?a?ie. Aeine?aeaeaiiy aoee i?iaaaeai? ia 56 aenia?eiaioaeueieo
oaa?eiao (40 ieoao e?i?? NAAoN57A1/6/F1 ? 16 ieoao e?i?? NAWA-16) c
ioe?ieith aieeao ia?aiie?i?aeo ia ia?aeiio aoii?aeueio a?aeiia?aeue, ia
ee?oeiio eaieo ?ioiii? a?aeiia?ae?. Aea/aiiy ooieoe?iiaeueiiai noaio
aoee i?iaaaeai? ia 21 ii?nuee?e naeioe?.

O ianoaaeaieo ae?iie aea/aee aiaiiac aeeooy, caoai?thaaiiy c ?aoaeueiith
oaaaith aei noaio iaino?oaeueii? oa ?ai?iaeoeoeaii? ooieoe??, i?iaiaeeee
ianoaaeaiiy iiei/ieo caeic, ueoiaeaeii? caeice c eiinoeueoaoe??th
aiaeie?eiieiaa (aea/aiiy eiaeiaeiie/oaaeueii? ooieoe?? ueoiaeaeii?
caeice, OCAe), i?iaiaeeee a?iaioaeueia i?oaiaa oa ?aeoaeueia
aeine?aeaeaiiy, aaeoa??ieia?/ia oa aaeoa??ineii?/ia aeine?aeaeaiiy
iace?a ia oei?o, eieueiineii?th, OCAe aai?oae?e, ii iieacaiiyi
iao?inaeuei?iai?ao?th, ?aioaaiineii?th /a?aia, aea/aee eiaaoeia?aio
e?ia?. Aeiaeaoeiai oai?? iaeyaeaeenue oa?aiaaoii, iaa?iiaoieiaii,
ineoioa?aiaaoii, o?ieiaii.

Noai y?/iee?a aea/aany ca oanoaie ooieoe?iiaeueii? ae?aaiinoeee c
ianooiiei aecia/aiiyi a e?ia? y?/ieeiaeo ? a?iio?ca?ieo ai?iii?a.
Ee?i?/i?, eaai?aoi?i? ? ia?aee?i?/i? aeine?aeaeaiiy aoee i?iaaaeai? a
eaai?aoi??yo ?aae?i?ioiieia?/iiai oa ?ioiioa?iaioiiai aiae?co eaoaae?e
ia?eiaoaeueii? iaaeeoeeie, aeeoy/i? oa i?aee?oeiai? a?iaeieia??
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ooieoe?iiaeueio aeoeai?noue noaoaaeo, iaaeie?eiaeo caeic ? noai
aiiaaeio?iiii? ?aaoeyoe?? ioe?ithaaee ca ??aiai noa?i?aeieo ai?iii?a o
ne?iaaooe? e?ia?, aecia/ath/e ?o ?aae?i?ioiieia?/ieie oa
?ioiioa?iaioieie caniaaie c aeei?enoaiiyi noaiaea?oieo iaai??a o??i:
aeey aecia/aiiy eiioeaio?aoe?? ei?oecieo, ano?aae?ieo, i?iaanoa?iio
aeei?enoiaoaaee iaai?e ??ciiiai?oieo o??i: OOA-AOE (Aa?iai?y,
IE-I???E-?r, O?aioe?y), ano?aae?ie-noa?ii-A2-j125 (?in?y), Nis
(O?aioe?y), i?iaanoa?ii — Nis, (O?aioe?y), ei?oecie-noa?ii-E-j125
(?in?y), ano??ie (?in?y). I?ae?aooiie i?iaiaeeee a eaia?? (-12 (?in?y) c
ianooiiei eiii’thoa?iei aiae?cii, a oaeiae ia i?eeaae? Cobas-Core.

Noai ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio ioe?ithaaee ca iieacieeaie
ooieoe?iiaeueiiai noaio iie?ii?oiiyaea?ieo eaeeioeeo?a (IssE).
Oa?iaioaoeaio aeoeai?noue IssE aecia/aee a iaceao ia?eoa?e/ii? e?ia?,
aeei?enoiaoth/e oeeoio?i?/i? iaoiaee. Oeeoio?i?/i? ?aaeoe?? ioe?ithaaee
iai?ae?euee?niei iaoiaeii c ?ic?aooieii na?aaeiueiai oeeoio?i?/iiai
eiao?oe??ioa (NOeE), ca /eneii aeoeaieo ee?oei (AE), ui i?noeee
i?iaeoeoe ?aaeoe?? a iiioeyoe?? aeine?aeaeaieo ee?oei oa a?noia?ai
?iciiae?eo ee?oei ca nooiaiai aeoeaiino?, a naia: ia?ieneaeaco
(aaiceae?iiaei iaoiaeii) ii Eeeee ?. (1969), eao?iii? a?eee (a
iinoaiiaoe? e?ciniiaeueii-eao?iiiiai oanoo) ii Ieaa?aaneiio A. A.
(1981), eeneo oinoaoaco (Eaaiiaa E. A., 1979). Ooieoe?iiaeueiee noai
IssE ioe?ithaaee oaeiae o ?aaeoe?yo niiioaiiiai oa “noeioeueiaaiiai”
NBT-oanoo (Aaaei?a TH. E., 1981).

Noaoenoe/io ia?iaeo io?eiaieo ?acoeueoao?a i?iaiaeeee iaoiaeii
aa??aoe?eii? noaoenoeee. ?ic?aoiaoaaee na?aaei? cia/aiiy (I), iiieeeo
na?aaeiuei? a?eoiaoe/ii? aaee/eie (m) oa eaaae?aoe/ia a?aeoeeaiiy
ie?aiiai aeiaaeeo ((). E?eoa??e a??ia?aeiino? (?) ia/enethaaee ca
ia?aiao?e/iei e?eoa???i No‘thaeaioa (t). A?aei?ii?noue iieaciee?a
aaaaeaeany a??ia?aeiith i?e ?<0,05. ?acoeueoaoe aeine?aeaeaiue Aenia?eiaioaeueia /anoeia ?iaioe. Aeeiiaii 3 na??? aiaeia?/ieo aenia?eiaio?a ca aeiiaaie Oa?ieii?oaoa IIC Oe?a?ie aei iiaeo e?ea?nueeeo cania?a. Ii??aiyiiy ?iaeaeno a?aei?iiinoae ii ?aaeoe?? a?ia?/ooeeaino? niia?eueithaaiiai oeio ? oeo?o aaethoei?i?a o ne?iaaooe? e?ia? anoaiiaeaii, ui a?i a??ia?aeii cieaeo?oueny i?e aaaaeaii? ia?aiie?i?aeo, a na?aaei?e ??aaiue lg2 oeo?a aaethoei?i?a o aenia?eiaioaeueieo oaa?ei /a?ac 7 aei?a i?ney ?ioi?caoe?? neeaa 5,90±0,48 i?ioe 9,4±0,08 (?<0,001) a eiio?ieuei?e a?oi?. ?iaeaene noeioeyoe?? aeoeaii ooai?thth/eo ee?oei aeey ia?aiie?i?aeo a caeaaeiino? a?ae aeo?aeiiai ??aiy noaio ?ioiii? a?aeiia?ae? aoee a 3-8 ?ac aeu? a ii??aiyii? c eiio?ieai. Anoaiiaeaii oaeiae, ui c 10 aeiy aaaaeaiiy ia?aiie?i?aeo a??ia?aeii i?aeaeuo?oueny oaaioeeoa?ia aeoeai?noue oa ca?eueoo?oueny oaaioeeoa?ia /enei c iaeneiaeueieie ?o iieacieeaie ia 14 ? 21 aeaiue. Oaeei /eiii iieacaii, ui ia?aiie?i?ae ia? ?ioiiiiaeoethth/ee aieea ye ia ee?oeiio aoii?aeueio eaieo ?ioiii? a?aeiia?ae?, oae ? iiceoeaiee aieea ia noai ianiaoeeo?/ieo oaeoi??a caoenoo i?aai?cio aenia?eiaioaeueieo oaa?ei. Ee?i?/ia /anoeia ?iaioe. Aea/aiiy noaio iaino?oaeueii? ooieoe?? o ae?iie ?c caiaeueieie caoai?thaaiiyie aeiaeaoe?a iaoee iieacaei, ui ia?aaaaeiei aoei o ieo ii?ooaiiy ooieoe?iiaeueiiai noaio y?/iee?a ii oeio a?iiano?iaai?? c aiiaoeyoi?iei oeeeeii – o 67 (40,1%) ae?iie. A?iiano?iaai?y c iaoeyoi?iei oeeeeii aeyaeaia o 20 (12%), ii?iiano?iaai?y c? caa?aaeaiiyi iaoeyoi?iiai oeeeeo o 30 (17,9%) aeiaaeeao. Ia?aeiiei ? aoi?eiiei aacie?aeaeyi no?aaeaeaee 50 (29,9%) ae?iie, i?e oeueiio o 38 (76%) aiii niinoa??aaeinue i?ney iieia?a aai aai?o?a. O?eaae?noue aoi?eiiiai aacie?aeaey eieeaaeanue a?ae 3 aei 11 ?ie?a (24,1%), ia?aeiiiai – a?ae 2 aei 7 ?ie?a (19,6%). Iaaeiiooaaiiy aaa?oiino? eiinoaoiaaii o 15 (9%) ae?iie. Anoaiiaeaii, ui ??aaiue ii?ooaiue iaino?oaeueii? oa ?ai?iaeoeoeaii? ooieoe?e o?nii iia‘ycaiee c o?eaae?noth ia?aa?ao o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a iaoee. Aea/aiiy ooieoe?iiaeueii? aeoeaiino? IssE e?ia? ye o caei?iaeo ae?iie, oae ? o oai?eo i?iaiaeeeiny i?ioyaii iaino?oaeueiiai oeeeeo aei, a i?ioean? oa ii cae?i/aii? e?eoaaiiy c aeei?enoaiiyi iiaiai i?aia?aoo aaii?aai?/ii? i?e?iaee – ia?aiie?i?aeo. Ca iaoeie aeaieie, ooieoe?iiaeueia aeoeai?noue eenei? oinoaoace (EO) ye iaeiiai c a?ae?ie?oe/ieo oa?iaio?a IssE iiaea aooe iaei??th c iaea?eueo cia/oueo iieaciee?a noaio eaeeioeeo?a. O ae?iie c OCIAeI, a oe?eiio ii a?oi?, NOeE EO o IssE aei??aithaaa 0,76±0,011, ui a??ia?aeii a?ae??ciy?oueny a?ae oaeiai iieacieea o caei?iaeo ae?iie o 2 oaco iaino?oaeueiiai oeeeeo (0,83±0,011). A?eueo i?ae o 2/3 ianoaaeaieo aei e?eoaaiiy aoa anoaiiaeaiee a?iiethoa?i?ci ?c nei?i/aiiyi 2 oace aai aiiaoeyoi?iee oei iaino?oaeueiiai oeeeeo. I?e aiae?c? iieaciee?a NOeE EO o IssE ii a?aeiioaiith aei o?eaaeino? caoai?thaaiiy c‘yniaaia /?oea oaiaeaioe?y ciaioaiiy eiai aei a?eueo iecueeeo /eneiaeo cia/aiue i?e o?eaaeino? caoai?thaaiiy 5 oa a?eueoa ?ie?a. Oae, o ae?iie c o?eaae?noth caoai?thaaiiy aei 3 ?ie?a a?i noaiiaea 0,79±0,017, a a a?oi? aei 5 ?ie?a - 0,81±0,016 ? aeua 5 ?ie?a a?i aei??aithaaa 0,77±0,020 (i?e 0,83±0,011 o i?aeoe/ii caei?iaeo ae?iie). O an?o ae?iie c OCIAeI iaei i?noea cieaeaiiy ooieoe?iiaeueii? aeoeaiino? IssE iacaeaaeii a?ae ee?i?/ii? oi?ie ia?aa?ao i?ioeano, aea /?oei aca?iica’ycaia c o?eaae?noth caoai?thaaiiy oa c? nooiaiai ii?ooaiue aiaeie?eiii? ?aaoeyoe?? ooieoe?? y?/iee?a. Iaea?eueo iecuee? cia/aiiy NOeE EO o IssE iaee i?noea o ae?iie c ee?i?/ieie a‘yeioaeo/eie oa ?aoeeaeeaoth/eie oi?iaie o?ii?/iiai naeuei?iaiioi?eoo (0,68±0,014 ? 0,71±0,012). A?noia?aie ?iciiae?eo ee?oei ca ??aiai aeoeaiino? EO o ae?iie c o?ii?/ieie naeuei?iaiioi?eoaie iieacaee, ui a ii??aiyii? c? caei?iaeie ae?ieaie a?eueoa /anoeia c ieo iecueeiaeoeaia (1 nooi?iue). A ii?i? o i?aeoe/ii caei?iaeo ae?iie ??aaiue ee?oei 2 ? 3 nooiaiy aeoeaiino? iaee oaiaeaioe?th aei ca?eueoaiiy o 2 oaco iaino?oaeueiiai oeeeeo, ui ia aeyaeyeinue o oai?eo. Ia aeyaeaii ?noioii? ??cieoe? i?ae aeeiai?eith ii?iae?caoe?? NOeE EO o IssE o caeaaeiino? a?ae ia?aioa?aeueiiai aaaaeaiiy ia?aiie?i?aeo aai canoinoaaiiy eiai ca aeiiiiiaith nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco (0,81±0,010 i?ioe 0,82±0,011, ?>0,05). O oie aea /an o?eueee a a?oi?
ae?iie, aea ia?aiie?i?ae aaiaeeany ca aeiiiiiaith nae?i-aaaeii?iaeueiiai
aeaeo?ioi?aco, niinoa??aaeanue a??ia?aeia ??cieoey iieaciee?a EO o
ii??aiyii? c aiaeia?/ieie a a?oi? eiio?ieth.

?ioii-aiaeie?eii? aca?iia?aeiioaiiy iaee ?noioia cia/aiiy aeey
ooieoe?iiaeueiiai noaio IssE ca aeoeai?noth a ieo eenei? oinoaoace. Oae,
o a?oi? ae?iie c a?iiano?iaai??th ? a?iiethoa?i?ciii, aeei?enoaiiy
ia?aiie?i?aeo ia i?eaiaeeei aei aeoea?caoe?? a?ae?ie?oe/ii? aeoeaiino?
EO o IssE (0,77±0,011 aei ? 0,76±0,010 i?ney e?eoaaiiy, ?>0,05).
Aeiyoeii aoea a?oia ae?iie c o?eaae?noth caoai?thaaiiy aei 3 ?ie?a
(0,79±0,017 aei ? 0,84±0,012 i?ney e?eoaaiiy, ?<0,05) ? ae?iee c ii?iiano?iaai??th aai aeaui c? cieaeaiei ??aiai ano?iaai?a a I oac? oeeeeo oa c a?aeiiniei a?iiethoa?i?ciii (c? caa?aaeaiiyi iaoeyoi?iiai oeeeeo) – 0,74±0,011 aei ? 0,80±0,010 i?ney e?eoaaiiy, ?<0,05. NEOe aeoeaiino? II o IssE, a oe?eiio ii a?oi?, aei e?eoaaiiy aei??aithaaa 2,78±0,03, ui a??ia?aeii ieae/a a ii??aiyii? c a?oiith i?aeoe/ii caei?iaeo ae?iie (3,01±0,01). O ae?iie c OCIAeI (c a‘yeioaeo/ei ee?i?/iei ia?aa?aii caoai?thaaiiy) ai?no NOeE II o IssE cieaeo?oueny (?<0,05). Iaea?eueo iecuee? eiai cia/aiiy oa?aeoa?i? aeey a?oie ae?iie c ia?aa?aii caoai?thaaiiy a?eueoa 5 ?ie?a i?e nia?/ieo oi?iao (2,69±0,04), c /anoeie caaino?aiiyie i?ioeano (2,63±0,02) oa c a‘yeioaeo/ei ia?aa?aii (2,64±0,03) naeuei?iaiioi?eoo. Ca aeaieie a?noia?ai ?iciiae?eo aeoeaiino? II aoei aeyaeaii cieaeaiiy e?eueeino? aeoeaieo ee?oei 1 ? 2 nooiaiy, a i?e o?eaaeiio ia?aa?ao caoai?thaaiue - 2 ? 3 nooiaiy. I?ney i?iaaaeaiiy eiiieaenii? oa?ai?? NOeE II o IssE a a?oi? ae?iie c o?eaae?noth caoai?thaaiiy aei 3 ?ie?a c?inoaa aei 2,97±0,03 i?ioe 2,78±0,03 aei e?eoaaiiy (?<0,05). Iaeiae ii?iae?caoe?y NOeE II o IssE ii a?aeiioaiith aei ??aiy oaeiai a a?oi? i?aeoe/ii caei?iaeo ae?iie, a i?ioeeaaei?noue a?ae aeneiaeaiiai ca?eueoaiiy aeoeaiino? NOeE EO o IssE ia aoei. Oaeei /eiii, i?ae aieeaii eiiieaenii? oa?ai?? o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a iaoee ??aaiue II o IssE ia ii?iae?co?oueny i?ioe /?oeiai eiai ca?eueoaiiy ii a?aeiioaiith aei aeo?aeiiai ??aiy aei e?eoaaiiy (?<0,05). O noeioeyoe?? ia?ieneaeacii? aeoeaiino? iaeo?io?e?a iaea cia/aiiy ia o?eueee eiiieaenia oa?ai?y c canoinoaaiiyi ia?aiie?i?aeo, aea ? niin?a aaaaeaiiy i?aia?aoo (nae?i-aaaeii?iaeueiee aeaeo?ioi?ac). Aeai? a?aeaeaeaieo niinoa?aaeaiue (a?ae 1 i?nyoey aei 1 ?ieo) iieacothoue, ui ?aoeeaeea o?ii?/iiai naeuei?iaiioi?eoo i?e nae?i-aaaeii?iaeueiiio oeyoo aaaaeaiiy i?aia?aoo niinoa??aaany cia/ii ??aeoa. O a?oi? ae?iie c? no?eeith ia?iaiaioiith a?iiano?iaai??th NOeE II o IssE i?ney e?eoaaiiy neeaa o?eueee 2,83±0,02, a a oe?eiio ii a?oi? a?i aei??aithaaa 2,86±0,02 i?e ia?aioa?aeueiiio aaaaeaii? i?aia?aoo ? 2,87±0,02 i?e aaaaeaii? ia?aiie?i?aeo ca aeiiiiiaith aeaeo?ioi?aco. Iiae?aia oaiaeaioe?y caa??aa?oueny ? aeey /eneiaeo cia/aiue NOeE o caeaaeiino? a?ae o?eaaeino? caoai?thaaiiy. Oae, a a?oi? ae?iie c o?eaae?noth aei 3 ?ie?a a?i neeaaeaa 2,91±0,02, i?e o?eaaeino? caoai?thaaiiy aei 5 ?ie?a - 2,88±0,01 ? iiiaae 5 ?ie?a - 2,77±0,03 (?<0,01). I?e ii?iiano?iaai?? oa a?iiethoa?i?ci? NOeE aeoeaiino? oa?iaioo ii cae?i/aii? e?eoaaiiy aoa aeua (2,88±0,03) ye a oe?eiio, oae ? o ae?iie c o?eaae?noth caoai?thaaiiy iiiaae 5 ?ie?a (2,78±0,03, ?<0,05). Ai?no EA o IssE ??ciee ii a?aeiioaiith aei o?eaaeino? ia?aa?ao caoai?thaaiiy ? iacaeaaeiee a?ae ee?i?/ii? oi?ie o?ii?/iiai caiaeueiiai i?ioeano aeiaeaoe?a iaoee. O ae?iie c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a eiai iieaciee aoa iaeiaioei (2,44±0,02), a aei 3 ?ie?a iaeaeuei (2,56±0,02). A??ia?aeia ??cieoey NOeE EA o IssE niinoa??aa?oueny o?eueee o oai?eo c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a (?<0,05). O a?oi? ae?iie c a‘yeioaeo/ei i?ioeanii oeae iieaciee aoa iaeiaioei (2,37±0,03). Aeey a?noia?ai ?iciiae?eo EA o IssE a ii?i? oa?aeoa?ia i?enooi?noue ee?oei 2 ? 3 nooiaiy aeoeaiino? ? i?aeoe/ia a?aenooi?noue ee?oei c 0, 1 ? 5 nooiai?a. O a?oiao ae?iie c o?eaae?noth caoai?thaaiiy aei 3 ? aei 5 ?ie?a iiae?aia ni?aa?aeiioaiiy caa??aa?oueny. A a a?oi? ae?iie ?c o?eaae?noth caoai?thaaiiy iiiaae 5 ?ie?a ciaioo?oueny /enei ee?oei 3 ? 4 nooiaiy c? ca?eueoaiiyi /enea ee?oei 2 nooiaiy aeoeaiino?, ui iiaea na?ae/eoe i?i cieaeaiiy aaeoa?eoeeaeii? ni?iiiaeiino? IssE a oe?eiio. I?ae aieeaii eiiieaenii? oa?ai?? ?c canoinoaaiiyi ia?aiie?i?aeo ai?no EA o IssE ia?eoa?e/ii? e?ia? ianoaaeaieo a oe?eiio i?aeaeuo?oueny (?<0,05). NOeE EA o a?oi? oai?eo c ia?aioa?aeueiei aaaaeaiiyi ia?aiie?i?aeo neeaa 2,62±0,02 i?ioe 2,55±0,02 aei e?eoaaiiy (?<0,01). Ia a?aei?io a?ae oa?iaioaoeaii? aeoeaiino? EO, a a?eueo?e i??? ? II a iaio?e, aeeiai?ea ai?noo EA o IssE ia a?ae??ciyeany a a?oi? oai?eo, ui iaea?aeoaaee ia?aiie?i?ae ia?aioa?aeueiei oeyoii (2,62±0,02) aai ca aeiiiiiaith nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco (2,61±0,02). I?e iayaiino? o oai?eo ii?iaeueiiai aai iacia/iiai cieaeaiiy ??aiy ano?iaai?a ? i?iaanoa?iia (i?e aeaioaciiio iaino?oaeueiiio oeeee?) ai?no EA o IssE ia?eoa?e/ii? e?ia? aei??aithaaa 2,61±0,02 i?ioe 2,55±0,02 aei e?eoaaiiy ? ia caeaaeaa a?ae o?eaaeino? ia?aa?ao caoai?thaaiiy. A oie aea /an o oai?eo c aiiaoeyoi?iei iaino?oaeueiei oeeeeii a?i aei??aithaaa 2,58±0,02 i?ioe 2,55±0,02 aei e?eoaaiiy (?>0,05).

A oe?eiio ii a?oi? o ae?iie c OCIAeI iieaciee niiioaiiiai NBT-oanoo
a??ia?aeii cieaeoth?oueny (?<0,05) ? a caeaaeiino? a?ae o?eaaeino? ia?aa?ao caoai?thaaiiy iaaeoi a?ae??ciy?oueny. Iaea?eueo iecuee? eiai cia/aiiy aoee a a?oi? ae?iie ?c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a (1,59±0,05) ?, ye i?aaeei, ia caeaaeaee a?ae ee?i?/iiai aa??aioo ia?aa?ao caoai?thaaiiy. Aeei?enoaiiy aeiaeaoeiai? noeioeyoe?? eaeeioeeo?a in vitro iieaco?, ui e?euee?noue ee?oei niiioaiii ?aaeoeoth/eo NBT-aa?aiee, ui a?aeia?aaea? oaaioeeoa?iee ?aca?a o a?oi? ae?iie c a?eueo o?eaaeei ia?aa?aii caiaeueiiai i?ioeano aeiaeaoe?a iaoee, ?noioii ia ciaioo?oueny. Oae, yeui iieaciee “noeioeueiaaiiai” NBT-oanoo a oe?eiio ii a?oi? oai?eo neeaaeaa 1,80±0,02, oi a a?oi? ae?iie c o?eaae?noth caoai?thaaiiy iiiaae 5 ?ie?a a?i aei??aithaaa 1,77±0,03. Iieaciee oaaioeeoa?iiai ?aca?ao (aei 2,80±0,18) ia a?aei?io a?ae oaeiai a a?oi? i?aeoe/ii caei?iaeo ae?iie ciaioo?oueny (3,14±019, p<0,05). Ii??aiyeueia ioe?iea canoinoaaiiy ia?aiie?i?aeo a eiiieaeni?e oa?ai?? oai?eo c eiai ia?aioa?aeueiei aaaaeaiiyi (1,76±0,04 aei ? 1,89±0,02 i?ney e?eoaaiiy) ? ca aeiiiiiaith nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco (1,77±0,03 ? 1,90±0,03) iieacaea, ui a??ia?aeieo a?aei?iiinoae o iieacieeao niiioaiiiai ? “noeioeueiaaiiai” NBT-oanoo i?e oiio aai ?ioiio iaoiae? canoinoaaiiy ia ciaeaeaii (?>0,05).

?acoeueoaoe aeine?aeaeaiue eiioeaio?aoe?? ai?iii?a ia?eoa?e/ii? e?ia? o
oai?eo OCIAeI na?ae/aoue i?i ci?io ?o ??aiy o caeaaeiino? a?ae nooiaiy
i?iyao caiaeueiiai i?ioeano, ee?i?/ii? oi?ie oa o?eaaeino? ia?aa?ao
caoai?thaaiiy.

I?e /anoi ?aoeeaeeaoth/?e ee?i?/i?e oi?i? ia?aa?ao o?ii?/iiai
naeuei?iaiioi?eoo o 39% ae?iie niinoa??aaeiny cieaeaiiy ONA ? EA i?e
iaeeo aa??aoe?eieo ci?iao i?ieaeoeio. Eiao?oe??io ONA:EA aei??aithaaa
1:45 (o caei?iaeo ae?iie 1:98). O oai?eo OCIAeI, ye? noi?iaiaeaeoaaeenue
a?iiano?iaai??th oa cieaeaiiyi ??aiy ano?aae?ieo o e?ia?, aoei iia’ycaia
c ii?ooaiiyi iaoeyoi?iiai aeeeaeo EA, a o a?eueoino? ae?iie aoei
aeyaeaii cieaeaiiy i?iaanoa?iio o ae?oao oaco iaino?oaeueiiai oeeeeo.
Oaiaeaioe?y aei ca?eueoaiiy ai?noo oanoinoa?iio aoea a a?oi? ae?iie c
ia?aa?aii caoai?thaaiiy iiiaae 5 ?ie?a. Ca ai?noii ano?aae?ieo
a??ia?aei?noue a?aei?iiinoae niinoa??aaeanue o ia?eiaoeyoi?iee ia??iae.

O ae?iie OCIAeI ?c a‘yeioaeo/ei ia?aa?aii i?ioeano o ia?eiaoeyoi?iee
ia??iae ??aaiue ONA aoa cia/ii iaioei, i?ae o oai?eo c ?ioeie ee?i?/ieie
oi?iaie o?ii?/iiai naeuei?iaiioi?eoa. I?e i?aeaeuaiiio ??ai? EA o I ? II
oac? iaino?oaeueiiai oeeeeo ? a ia?eiaoeyoi?iee ia??iae, ui oa?aeoa?ii
aeey neiae?iio IEss, ??aaiue ano?aae?ieo, i?iaanoa?iio ? ei?oecieo aoa
oaeiae cieaeaiee, oi/a ??aaiue oanoinoa?iio aoa i?aeaeuaiee
(a?ia?aiae?iaai?y). Oaeiae ?noioii ca?eueooaaany ??aaiue i?ieaeoeio, ui
na?ae/eoue i?i oaiaeaioe?th aei a?ia?i?ieaeoeiai??.

O ae?iie c ?oaoeaai-nia?/iei i?ioeanii niinoa??aaeiny iiieaeaiiy ??aiy
ONA ? EA /ano?oa i?e ii?iaeueiiio ??ai? i?ieaeoeio. Iaeiae
ni?aa?aeiioaiiy ONA/EA aoei a iaaeao 1:1 – 1:1,5 ? o aeaieo aeiaaeeao
niinoa??aaeiny iaea?eueo cia/ia cieaeaiiy ??aiy i?iaanoa?iio,
ano?aae?ieo, ui na?ae/eoue i?i no?eea o?aaeaiiy caiaeueiei i?ioeanii
oie?eoey?iiai aia?aoo y?/iee?a.

Oaeei /eiii, aeey eiaeiiai ee?i?/iiai aa??aioo OCIAeI ?nio? oa?aeoa?iee
oei a?iioaeaii-a?iio?ca?ii-y?/ieeiai? ?aaoeyoe??, ui iaiao?aeii
a?aoiaoaaoe i?e i?ecia/aii? oiai /e ?ioiai oa?aiaaoe/iiai eiiieaeno.

Aecia/aiiy ai?noo ai?iii?a o ae?oao oaco iaino?oaeueiiai oeeeeo i?ney
i?iaaaeaiiy cai?iiiiiaaii? iaie eiiieaenii? oa?ai?? ?c canoinoaaiiyi
ia?aiie?i?aeo (oaae. 1) iieacaei eeoa ca?eueoaiiy ai?noo i?iaanoa?iio o
a?oi? ae?iie c ?oaoeaai-nia?/iei i?ioeanii, a oaeiae ii?iae?caoe?th
??aiy ei?oecieo o a?oi? ae?iie c /anoeie caaino?aiiyie caoai?thaaiiy.
A??ia?aei?noue a?aei?iiinoae ?nio? aeey a?eueoino? iieaciee?a
ooieoe?iiaeueiiai noaio a?iio?ca?ii-y?/ieeiai? ?aaoeyoe?? o ae?iie c
o?eaae?noth ia?aa?ao caoai?thaaiiy aei 3 ?ie?a ? o 49,3% niinoa?aaeaiue
– i?e o?eaaeino? caoai?thaaiiy iiiaae 5 ?ie?a. Oea ? iieacieeii aeey
i?ecia/aiiy iiaoi?iiai eo?no oa?ai?? ?c canoinoaaiiyi ia?aiie?i?aeo.

O o?niiio aca?iica’yceo c ee?i?/iei aoaeoii eiiieaeniiai e?eoaaiiy
ciaoiaeyoueny ?acoeueoaoe aecia/aiiy ??aiy ai?iii?a ueoiaeaeii? caeice.
Oae, ?? a?iiooieoe?y, o a?oi? c /anoeie caaino?aiiyie, eiinoaoiaaia o 11
ae?iie, a?ia?ooeoe?y o 20, a aooi?ioiiee oe?ai?aeeo o 4 ae?iie. O a?oi?
c a‘yeioaeo/ei i?ioeanii a?iiooieoe?y niinoa??aaeany o 14 ae?iie,
a?ia?ooieoe?y o 19 oa aooi?ioiiee o??ai?aeeo o 9 ae?iie. O a?oi? c
?oaoeaai-nia?/iei i?ioeanii a?iiooieoe?y eiinoaoiaaia o 14 ae?iie,
a?ia?ooieoe?y o 7, a aooi?ioiiee oe?ai?aeeo i? o aeiaeii? ae?iee. I?ae
aieeaii eiiieaenii? oa?ai?? ?c canoinoaaiiyi ia?aiie?i?aeo
ooieoe?iiaeueiee noai ueoiaeaeii? caeice o a?eueoino? oai?eo OCIAeI
ii?iae?co?oueny, ui na?ae/eoue i?i o?niee ca‘ycie aeo?aeieo ii?ooaiue ??
ooieoe?? c? noaiii aioo??oi?o noaoaaeo i?aai?a ae?iee (oaae. 2).

Oaeei /eiii, eiiieaenia oa?ai?y OCIAeI ?c canoinoaaiiyi ia?aiie?i?aeo ye
?ioiiiiaeoeyoi?a oa aaeaioiaaia iiaea aooe ?aeiiaiaeiaaia aeey
ai?iaaaeaeaiiy a a?iaeieia?/io i?aeoeeo, oae ye aiia iiceoeaii aieeaa?
ia iie?auaiiy noaio ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio ? ii?iae?co?
a?iio?ca?ii-oe?ai?aei? aca?iia?aeiineie i?e iiceoeaiiio ee?i?/iiio
aoaeo? i?ney 1-3 eo?n?a e?eoaaiiy (a 93,3% aeiaaee?a).

Oaaeeoey 1

Ai?no ai?iii?a e?ia? o oai?eo o?ii?/ieie caiaeueieie i?ioeanaie
aeiaeaoe?a iaoee

aei oa i?ney eiiieaenii? oa?ai?? c canoinoaaiiyi ia?aiie?i?aeo (M SYMBOL
177 \f «Kino MT» \s 13 ± m)

Ai?iii E e ? i ? / i ? a ? o i e

c /anoei caaino?aiiyi

caoai?thaaiiy (n=41 ) c a`yeioaeo/ee ia?aa?a

i?ioeano (n=53) c ?oaoeaai-nia?/iei

i?ioeanii (n=28)

aei e?eoaaiiy i?ney e?eoaaiiy aei e?eoaaiiy i?ney e?eoaaiiy aei
e?eoaaiiy i?ney e?eoaaiiy

ONA, iea/e 2,4 SYMBOL 177 \f «Kino MT» \s 13 ± 0,4 2,64 SYMBOL 177 \f
«Kino MT» \s 13 ± 0,5 2,4 SYMBOL 177 \f «Kino MT» \s 13 ± 0,6 3,01
SYMBOL 177 \f «Kino MT» \s 13 ± 0,5 2,6 SYMBOL 177 \f «Kino MT» \s 13 ±
0,8 2,99 SYMBOL 177 \f «Kino MT» \s 13 ± 0,3

EA, iea/e 2,4 SYMBOL 177 \f «Kino MT» \s 13 ± 1,1 4,1 SYMBOL 177 \f
«Kino MT» \s 13 ± 0,8 5,95 SYMBOL 177 \f «Kino MT» \s 13 ± 0,8 5,7
SYMBOL 177 \f «Kino MT» \s 13 ± 0,6 4,11 SYMBOL 177 \f «Kino MT» \s 13 ±
0,7 5,0 SYMBOL 177 \f «Kino MT» \s 13 ± 0,4

I?ieaeoei, iea/e 262,3 SYMBOL 177 \f «Kino MT» \s 13 ± 35,5 269,0 SYMBOL
177 \f «Kino MT» \s 13 ± 31,2 371,0 SYMBOL 177 \f «Kino MT» \s 13 ± 78,6
292,3 SYMBOL 177 \f «Kino MT» \s 13 ± 14,9 295,7 SYMBOL 177 \f «Kino MT»
\s 13 ± 17,4 252,4 SYMBOL 177 \f «Kino MT» \s 13 ± 8,9

Ano?aae?ie, iiieue/e 430,0 SYMBOL 177 \f «Kino MT» \s 13 ± 68,3 463,3
SYMBOL 177 \f «Kino MT» \s 13 ± 52,2 485,6 SYMBOL 177 \f «Kino MT» \s 13
± 54,5 478,3 SYMBOL 177 \f «Kino MT» \s 13 ± 42,3 303,7 SYMBOL 177 \f
«Kino MT» \s 13 ± 39,6 362,3 SYMBOL 177 \f «Kino MT» \s 13 ± 24,1

I?iaanoa?ii, iiieue/e 29,1 SYMBOL 177 \f «Kino MT» \s 13 ± 9,4 34,3
SYMBOL 177 \f «Kino MT» \s 13 ± 8,2 20,2 SYMBOL 177 \f «Kino MT» \s 13 ±
8,6 30,3 SYMBOL 177 \f «Kino MT» \s 13 ± 5,4 11,9 SYMBOL 177 \f «Kino
MT» \s 13 ± 1,4 21,4 SYMBOL 177 \f «Kino MT» \s 13 ± 1,7*

Oanoinoa?ii, iiieue/e 3,39 SYMBOL 177 \f «Kino MT» \s 13 ± 2,1 2,5
SYMBOL 177 \f «Kino MT» \s 13 ± 1,8 2,09 SYMBOL 177 \f «Kino MT» \s 13 ±
0,1 2,01 SYMBOL 177 \f «Kino MT» \s 13 ± 0,15 2,0 SYMBOL 177 \f «Kino
MT» \s 13 ± 0,09 1,9 SYMBOL 177 \f «Kino MT» \s 13 ± 0,08

Ei?oecie, iiieue/e 341,6 SYMBOL 177 \f «Kino MT» \s 13 ± 16,5 298,72
SYMBOL 177 \f «Kino MT» \s 13 ± 14,3* 271,3 SYMBOL 177 \f «Kino MT» \s
13 ± 15,9 249,3 SYMBOL 177 \f «Kino MT» \s 13 ± 13,4 260,4 SYMBOL 177 \f
«Kino MT» \s 13 ± 19,8 240,1 SYMBOL 177 \f «Kino MT» \s 13 ± 11,8

Oaaeeoey 2

??aaiue ai?iii?a ueoiaeaeii? caeice o oai?eo o?ii?/ieie caiaeueieie
i?ioeanaie aeiaeaoe?a iaoee

aei oa i?ney oa?ai?? c canoinoaaiiyi ia?aiie?i?aeo (I SYMBOL 177 \f
«Kino MT» \s 13 ± m)

Ooieoe?iiaeueiee noai

ueoiaeaeii? caeice E e ? i ? / i ? a ? o i e

c /anoei caaino?aiiyi

caoai?thaaiiy c a`yeioaeo/ei ia?aa?aii

i?ioeano c ?oaoeaai-nia?/iei

i?ioeanii

aei e?eoaaiiy i?ney e?eoaaiiy aei e?eoaaiiy i?ney e?eoaaiiy aei
e?eoaaiiy i?ney e?eoaaiiy

A?iiooieoe?y caeice n=11 n=14 n=14

OOA(iA/e)

O3 (iiieue/e)

O4 (iiieue/e) 8,22 SYMBOL 177 \f «Kino MT» \s 13 ± 2,4

1,49 SYMBOL 177 \f «Kino MT» \s 13 ± 0,21

61,75 SYMBOL 177 \f «Kino MT» \s 13 ± 19,4 2,79 SYMBOL 177 \f «Kino MT»
\s 13 ± 1,1*

1,98 SYMBOL 177 \f «Kino MT» \s 13 ± 0,25

92,43 SYMBOL 177 \f «Kino MT» \s 13 ± 20,3 2,29 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,9

2,45 SYMBOL 177 \f «Kino MT» \s 13 ± 0,08

114,3 SYMBOL 177 \f «Kino MT» \s 13 ± 0,63 2,06 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,7

2,19 SYMBOL 177 \f «Kino MT» \s 13 ± 0,04*

106,5 SYMBOL 177 \f «Kino MT» \s 13 ± 0,59 0,85 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,08

2,98 SYMBOL 177 \f «Kino MT» \s 13 ± 0,44

160,3 SYMBOL 177 \f «Kino MT» \s 13 ± 1,3 1,39 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,04*

2,24 SYMBOL 177 \f «Kino MT» \s 13 ± 0,56

102,6 SYMBOL 177 \f «Kino MT» \s 13 ± 1,5*

A?ia?ooieoe?y caeice n=20 n=19 n=7

OOA(iA/e)

O3 (iiieue/e)

O4 (iiieue/e) 0,58 SYMBOL 177 \f «Kino MT» \s 13 ± 0,12

2,34 SYMBOL 177 \f «Kino MT» \s 13 ± 0,52

152,4 SYMBOL 177 \f «Kino MT» \s 13 ± 14,1 1,32 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,11*

2,16 SYMBOL 177 \f «Kino MT» \s 13 ± 0,48

109,2 SYMBOL 177 \f «Kino MT» \s 13 ± 16,3* 1,32 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,05

0,84 SYMBOL 177 \f «Kino MT» \s 13 ± 0,06

74,5 SYMBOL 177 \f «Kino MT» \s 13 ± 0,78 1,84 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,06*

1,67 SYMBOL 177 \f «Kino MT» \s 13 ± 0,08*

62,4 SYMBOL 177 \f «Kino MT» \s 13 ± 0,92* 6,63 SYMBOL 177 \f «Kino MT»
\s 13 ± 1,7

1,42 SYMBOL 177 \f «Kino MT» \s 13 ± 0,5

71,7 SYMBOL 177 \f «Kino MT» \s 13 ± 12,3 2,1 SYMBOL 177 \f «Kino MT» \s
13 ± 1,06*

1,84 SYMBOL 177 \f «Kino MT» \s 13 ± 0,8

91,35 SYMBOL 177 \f «Kino MT» \s 13 ± 14,4

Aooi?ioiiee oe?ai?aeeo n=4 n=9 n=0

OOA(iA/e)

O3 (iiieue/e)

O4 (iiieue/e) 7,05 SYMBOL 177 \f «Kino MT» \s 13 ± 1,85

1,3 SYMBOL 177 \f «Kino MT» \s 13 ± 0,2

47,5 SYMBOL 177 \f «Kino MT» \s 13 ± 9,8 3,02 SYMBOL 177 \f «Kino MT» \s
13 ± 2,04

1,74 SYMBOL 177 \f «Kino MT» \s 13 ± 0,19

89,5 SYMBOL 177 \f «Kino MT» \s 13 ± 8,8* 2,95 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,03

2,48 SYMBOL 177 \f «Kino MT» \s 13 ± 0,16

99,4 SYMBOL 177 \f «Kino MT» \s 13 ± 10,5 2,20 SYMBOL 177 \f «Kino MT»
\s 13 ± 0,05*

2,23 SYMBOL 177 \f «Kino MT» \s 13 ± 0,18

100,3 SYMBOL 177 \f «Kino MT» \s 13 ± 14,2 — —

I?ei?oea. *- ??cieoey a??ia?aeia a?aeiinii iieaciee?a aei e?eoaaiiy.

AENIIAEE

1. Aenia?eiaioaeuei? aeine?aeaeaiiy iieacaee, ui i?aia?ao aaii?aai?/ii?
i?e?iaee ia?aiie?i?ae aieiae?? ?ioiiiiaeoethth/ei aieeaii ia aeaye?
eaiee nenoaie ?ioi?oaoo, ui iaoiiaeth? aeioe?euei?noue eiai canoinoaaiiy
o eiiieaeni?e oa?ai?? o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a iaoee.
Iaeneiaeuei? cia/aiiy iieaciee?a oaaioeeoa?ii? aeoeaiino? oa
oaaioeeoa?iiai /enea ianooiaee ia 14-21 aeaiue a?ae ii/aoeo eiai
canoinoaaiiy.

2. O?ii?/iee caiaeueiee i?ioean aeiaeaoe?a iaoee noi?iaiaeaeo?oueny
ci?iith ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio, ui i?iyaey?oueny
cieaeaiiyi ooieoe?iiaeueiiai noaio iie?ii?oiiyaea?ieo eaeeioeeo?a e?ia?.
Iaea?eueo? ci?ie iieaciee?a, ui oa?aeoa?ecothoue ooieoe?iiaeueiee noai
IssE (eenea oinoaoaca, ia?ieneaeaca, ai?no eao?iiieo a?ee?a, ??aaiue
niiioaiiiai oa “noeioeueiaaiiai” NBT-oanoo) iathoue i?noea o oai?eo c
/anoeie caaino?aiiyie caiaeueiiai i?ioeano ? o ae?iie c o?eaaeei
a`yeioaeo/ei naeuei?iaiioi?eoii. Iaio cia/ia cieaeaiiy eiinoaoiaaii o
ae?iie c o?ii?/iei ?oaoeaai-nia?/iei i?ioeanii aeiaeaoe?a iaoee.

3. O?eaaeee ia?aa?a o?ii?/iiai caiaeueiiai i?ioeano aeiaeaoe?a iaoee
noi?iaiaeaeo?oueny ii?ooaiiyi noa?i?aeiaaiaco y?/iee?a. I?e oeueiio
a?iiethoa?i?ci, ia?iaiaioia a?ia?ano?iaai?y ? aiiaoeyoe?y oa?aeoa?i?
aeey a?eueo o?eaaeiai a‘yeioaeo/iai i?ioeano. A?aeiinia a?ia?ano?iaai?y,
a?iiethoa?i?ci ? a?aeiinia a?ia?i?ieaeoeiai?y iathoue i?noea i?e
caoai?thaaiiyo, ui noi?iaiaeaeothoueny /anoeie caaino?aiiyie caiaeueiiai
i?ioeano ? a?ii – (/ano?oa) aai a?ia? – (??aeoa) oe?ai?aeeciii. Aeey
?oaoeaai-nia?/ii? ee?i?/ii? oi?ie o?ii?/iiai naeuei?iaiioi?eoo a?eueo
oa?aeoa?ia a?ia?i?ieaeoeiai?y, a?iiethoa?i?ci ? a?iioe?ai?aeiee noai
ueoiaeaeii? caeice.

4. ??ciiieaiia? ci?ie ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio a
caeaaeiino? a?ae ee?i?/ii? oi?ie ia?aa?ao caoai?thaaiiy, ii?ooaiiy
a?iio?ca?ii-y?/ieeiai? oa a?iio?ca?ii-oe?ai?aeii? ?aaoeyoe?? aeiaaathoue
aeeth/aiiy o noaie eiiieaenii? oa?ai?? e?eoaaeueieo cania?a, ui
aieiae?thoue ?ioiiiiaeoethth/ei aoaeoii ? ni?eythoue i?aeaeuaiith
aaeaioaoe?eii-i?enoinoaaeueieo ?aaeoe?e. Naia oaeei aeiiaai iiai?noth
a?aeiia?aea? i?aia?ao aaii?aai?/ii? i?e?iaee – ia?aiie?i?ae.

5. Eiiieaenia oa?ai?y o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a iaoee ?c
canoinoaaiiyi ia?aiie?i?aeo ni?ey? iie?ioaiith ooieoe?iiaeueiiai noaio
IssE e?ia?, ui iaea?eueo /?oei niinoa??aa?oueny a e?ioe? eiai eo?niaiai
aaaaeaiiy. Ia?aiie?i?ae iiaea canoiniaoaaoeny ye ia?aioa?aeueii, oae ?
ca aeiiiiiaith nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco (c 5 ii 25-27 aeaiue
iaino?oaeueiiai oeeeeo, uiaeiy, a iino?eiiio ?aaeei?). Aoaeoeai?noue
eiiieaenii? oa?ai?? ?c canoinoaaiiyi ia?aiie?i?aeo iii?oii c?inoa? ca
oiiae i?ecia/aiiy 2-3 eo?n?a e?eoaaiiy c ?ioa?aaeii 1-2 i?nyoe?.

6. Iiceoeaia aeeiai?ea ci?i iieaciee?a, oa?aeoa?ecoth/eo
ooieoe?iiaeueiee noai IssE (ia?ieneaeace, eenei? oinoaoace, ai?noo
eao?iiieo a?ee?a, ??aiy NBT-oanoo) oa iie?ioaiiy ooieoe?? y?/iee?a,
ueoiaeaeii? caeice ? cieaeaiiy ??aiy i?ieaeoeio (i?e iiia?aaeiueiio eiai
ca?eueoaii?), a on?o aeiaaeeao noi?iaiaeaeo?oueny ee?i?/iei aeaeoaeaiiyi
aai cia/iei iie?auaiiyi noaio oai?eo c o?ii?/ieie caiaeueieie
caoai?thaaiiyie aeiaeaoe?a iaoee. I?e oeueiio iaea?eueo aeioe?eueiei ?
i?ecia/aiiy iaoo?aeueieo aaeaioiaai?a ca aeiiiiiaith
nae?i-aaaeii?iaeueiiai aeaeo?ioi?aco, iniaeeai i?e iayaiino?
?oaoeaai-nia?/iiai o?ii?/iiai naeuei?iaiioi?eoo.

NIENIE IAOEIAEO ?IA?O

IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

1. Iaethe A.A. A?iioaeaii-a?iio?ca?ii-y?/ieeiaa ?aaoeyoe?y o oai?eo
o?ii?/ieie naeuei?iaiioi?eoaie o eiiieaeni?e oa?ai?? ?c aeayeeie iiaeie
oeaieiieie i?aia?aoaie. // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. —
1998. — ?11. — N. 135 — 142.

2. Iaethe A.A. Iniaaiiinoe aeeiaieee eeneie oinoaoacu a
iieeii?oiiyaea?iuo eaeeioeeoao o aieueiuo o?iie/aneeie ainiaeeoaeueiuie

caaieaaaieyie i?eaeaoeia iaoee n i?eiaiaieai ia?aiieeieyea. // Aanoiee
i?iaeai aeieiaee e iaaeeoeeiu. — 1998. — ?12. — N. 14 — 19.

3. Iaethe A.A. NBT-oano i?e ioe?ithaaii? ooieoe?iiaeueiiai noaio
iie?ii?oiiyaea?ieo eaeeioeeo?a o oai?eo ia caiaeuei? i?ioeane i?eaeaoe?a
iaoee c canoinoaaiiyi o eiiieaeni?e oa?ai?? ia?aiie?i??eo. // Iaeanueeee
iaaee/iee aeo?iae. — 1998. — ?5. — N. 34 — 36.

4. Iaethe A.A. I?eiaiaiea ia?aiieeieyea a eiiieaeniie oa?aiee
o?iie/aneeo ainiaeeoaeueiuo caaieaaaiee i?eaeaoeia iaoee. // Oace
iaoeiai? eiioa?aioe?? iooaeueiieia?a (c i?aeaeoia?iaeiith
o/anoth).-Iaeana, 1998.-N.270-271.

5. Iaethe A.A. Ee?i?/ia canoinoaaiiy ia?aiie?i?aea a oa?ai??
aeenooieoe?iiaeueieo iaoeiaeo e?iaioa/. // Oace ?ia?o O c‘?caeo
aeooa??a-a?iaeieia?a Oe?a?ie. — Iaeana. — 1996. — N. 53 — 54.

6. Iaethe A.A., E?eaeaiianeee A.O., Nioi?eiaa I.I. Canoinoaaiiy
aaeaioiaai?a aaii?aai?/ii? no?oeoo?e a eiiieaeni?e oa?ai?? o?ii?/ieo
caiaeueieo i?ioean?a aeiaeaoe?a iaoee. // Oace ?ia?o O c‘?caeo
aeooa??a-a?iaeieia?a Oe?a?ie. — Iaeana. — 1996. — N. 54 — 55.

7. Iaethe A.A. E aii?ino i oa/aiee aa?aiaiiinoe, oaeoeea aa aaaeaiey e
?iaei?ac?aoaiey i?e o?iie/aneeo ainiaeeoaeueiuo caaieaaaieyo i?eaeaoeia
iaoee. // Iaoa??aee iaoeiaeo ?ic?iaie. — Iaeana. — 1995. — N. 52 — 55.

8. Iaethe A.A. Iiaua aiciiaeiinoe eiiieaeniie oa?aiee naeueieiaiioi?eoia
a iiae?inoeiaii aic?anoa. // Oace 2-i? iaoeiai-i?aeoe/ii? eiioa?aioe??
e?ea??a aeooa??a-a?iaeieia?a Oe?a?ie aeeoy/iai oa i?aee?oeiaiai a?eo. —
Iaeana. — 1995. — N. 36 — 37.

AIIOAOe??

Iaethe A.A. Eiiieaeniay oa?aiey o?iie/aneeo ainiaeeoaeueiuo caaieaaaiee
i?eaeaoeia iaoee n i?eiaiaieai ia?aiieeieyea
(yenia?eiaioaeueii-eeeie/aneia enneaaeiaaiea) — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.01 — aeooa?noai e aeiaeieiaey — Iaeanneee
ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao IC Oe?aeiu. — Iaeanna, 1998.

Aeenna?oaoeey iicayuaia ea/aieth o?iie/aneeo ainiaeeoaeueiuo caaieaaaiee
i?eaeaoeia iaoee n i?eiaiaieai iiaiai i?aia?aoa aai?aaie/aneie no?oeoo?u
— ia?aiieeieyea. Ia iniiaaiee na?ee yenia?eiaioaeueiuo enneaaeiaaiee
onoaiiaeaii, /oi ii iaeaaeaao eiioiiiiaeoee?othuei aeeyieai ia
aoii?aeueiia caaii eiioieoaoa, yooaeoeaiinoue eioi?iai caaeneo io
enoiaeiiai o?iaiy aoii?aeueiiai caaia. Ia?aiieeieye niinianoaoao
iiauoaieth ooieoeeiiaeueiiai ninoiyiey eaeeioeeoia iooai oneeaiey
oaaioeeoa?iie aeoeaiinoe, eioi?ay aeinoeaaao naiaai iaeaunoaai o?iaiy e
14-21 aeith i?eiaiaiey i?aia?aoa.

O 122 aieueiuo o?iie/aneeie ainiaeeoaeueiuie caaieaaaieyie i?eaeaoeia
iaoee, a caaeneiinoe io aeeeoaeueiinoe e eeeie/aneie oi?iu oa/aiey, a
eiiieanioth oa?aieeth aue aeeth/ai ia?aiieeieye, eniieuecoaiue n
iiiiuueth nae?i-aaaeiieiaeueiiai yeaeo?ioi?aca (59 /aeiaae) e n
ia?aioa?aeueiui iooai aaaaeaiey i?aia?aoa (63 /aeiaaea). A eiio?ieueiie
a?oiia (45 /aeiaae) ia oiia eaeaioe/iie eiiieaeniie oa?aiee aue
eniieueciaai aeinoeioeyoi? iaeieaeiaeenoeeeyo. N ia?aiieeieyeii eo
iauaaeeiyao i?eioeei aeiaaiiiai i?ienoiaeaeaiey (ii?neay aiaea —
eeiaiiay a?ycue, niaea?aeauea eaeaioe/iua aeieiae/anee aeoeaiua
niaaeeiaiey, aoiaeyuea a eo ninoaa).

A ?acoeueoaoa eco/aiey ooieoeeiiaeueiiai ninoiyiey iieeii?oiiyaea?iuo
eaeeioeeoia n iiiiuueth oeeoioeie/aneeo iaoiaeia onoaiiaeaii
iieiaeeoaeueiia aeeyiea eiiieaeniie oa?aiee n i?eiaiaieai ia?aiieeieyea
ia ianiaoeeoe/aneoth ?acenoaioiinoue i?aaiecia i?e ?acee/iuo eeeie/aneeo
oi?iao ainiaeeoaeueiiai i?ioeanna. Iaeaieaa au?aaeaiiie iia auea o
aieueiuo n aeeeoaeueiui ayeioaeouei oa/aieai eee n /anouie iaino?aieyie
o?iie/aneiai ainiaeeoaeueiiai i?ioeanna i?eaeaoeia iaoee. O aieueiuo n
o?iie/aneei ?oaoeiai-niaa/iui i?ioeannii iieacaoaee, oa?aeoa?ecothuea
ninoiyiea ianiaoeeoe/aneie ?acenoaioiinoe i?aaiecia i?aeoe/anee ia
eciaiyeenue.

Iieacaoaee n?aaeiaai oeeoioeie/aneiai eiyooeoeeaioa (NOeE) eeneie
oinoaoacu, ia?ieneaeacu, o?iaiy eaoeiiiuo aaeeia, niiioaiiiai e
“noeioee?iaaiiiai” NBT-oanoa iiaoo auoue eniieueciaaiu, eae e?eoa?ee
ooieoeeiiaeueiiai ninoiyiey iieeii?oiiyaea?iuo eaeeioeeoia e
ii?aaeaeyoue eioaineaiinoue e i?iaeieaeeoaeueiinoue i?aaeeiaeaiiiai
oa?aiaaoe/aneiai eiiieaena n i?eiaiaieai ia?aiieeieyea.

Ii?aaeaeaia /aoeay caaeneiinoue ninoiyiee aeiioeca?ii-ye/ieeiaie e
aeiioeca?ii-oe?aieaeiie ?aaoeyoeee io eeeie/aneie oi?iu oa/aiey
o?iie/aneiai ainiaeeoaeueiiai i?ioeanna, /oi yaeyaony i?aeoe/anee
iaiaoiaeeiui aeey ?ac?aaioee e i?iaaaeaiey eiiieaeniie oa?aiee aeaiiiai
caaieaaaiey.

Enneaaeiaaieyie aeiioeca?ii-oe?aieaeiie ?aaoeyoeee onoaiiaeaii, /oi i?e
?acee/iuo eeeie/aneeo oi?iao oa/aiey o?iie/aneiai naeueieiaiioi?eoa
iaia?oaeaii ?acee/iia niaea?aeaiea aeiioeca?ii-ye/ieeiai-oe?aieaeiuo
ai?iiiia e ei?oeciea. Iaeaieaa /anouie auee ioiineoaeueiay
aeia?i?ieaeoeiaiey, ioiineoaeueiua aeiioe?aieaeiua e aeia?oe?aieaeiua
oeiu ?aaoeyoeee.

Yooaeoeaiinoue oa?aiaaoe/aneiai aeeyiey eiiieaeniie oa?aiee n
i?eiaiaieai ia?aiieeieyea o aieueiuo n o?iie/aneeie ainiaeeoaeueiuie
caaieaaaieyie i?eaeaoeia iaoee caaeneo io enoiaeiiai ninoiyiey
ianiaoeeoe/aneie ?acenoaioiinoe i?aaiecia e niinianoaoao ii?iaeecaoeee
ai?iiiaeueiuo acaeiiioiioaiee o aieueoeinoaa aieueiuo. Iieiaeeoaeueiue
eeeie/aneee yooaeo ea/aiey iinea i?iaaaeaiiuo eo?nia oa?aiee
iaaethaeaeny a 93,3% neo/aaa. ?acoeueoaou enneaaeiaaiee aiaae?aiu a
?aaioo ea/aaiuo o/?aaeaeaiee thaa Oe?aeiu.

Eeth/aaua neiaa: o?iie/aneee naeueieiaiioi?eo, iieeii?oiiyaea?iua
eaeeioeeou, oeaiaaay oa?aiey, aaeaioiaaiu, ia?aiieeieye, oeeoioeie/aneea
iaoiaeu enneaaeiaaiey, ai?iiiu ia?eoa?e/aneie e?iae, aanieiaeea.

Iaethe A.A. Eiiieaenia oa?ai?y o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a
iaoee ?c canoinoaaiiyi ia?aiie?i?aeo (aenia?eiaioaeueii-ee?i?/ia
aeine?aeaeaiiy) — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.01 — aeooa?noai oa a?iaeieia?y — Iaeanueeee
aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie. — Iaeana, 1998.

Aeena?oaoe?y i?enay/aia e?eoaaiith o?ii?/ieo caiaeueieo i?ioean?a
aeiaeaoe?a iaoee ?c canoinoaaiiyi aaeaioiaaia aaii?aai?/ii? i?e?iaee
ia?aiie?i?aeo. Ia i?aenoaa? na???? aenia?eiaioaeueieo aeine?aeaeaiue oa
aea/aiiy ooieoe?iiaeueiiai noaio iie?ii?oiiyaea?ieo eaeeioeeo?a ca
aeiiiiiaith oeeoio?i?/ieo iaoiae?a anoaiiaeaii iiceoeaiee aieea
eiiieaenii? oa?ai?? ?c canoinoaaiiyi ia?aiie?i?aeo c iie?auaiiyi
ianiaoeeo?/iiai caoenoo i?aai?cio i?e ??cieo ee?i?/ieo oi?iao
caiaeueiiai i?ioeano. A ?acoeueoao? aeine?aeaeaiiy
a?iio?ca?ii-oe?ai?aeii? ?aaoeyoe?? anoaiiaeaii, ui i?e oeo /e ?ioeo
ee?i?/ieo oi?iao ia?aa?ao o?ii?/ieo caiaeueieo i?ioean?a aeiaeaoe?a
iaoee niinoa??aa?oueny ??ciee ai?no a?iio?ca?ii-y?/ieeiai-oe?ai?aeieo
ai?iii?a oa ei?oecieo. Aeeth/aiiy aei eiiieaeno e?eoaaeueieo cania?a
ia?aiie?i?aeo ni?ey? ii?iae?caoe?? ai?iiiaeueieo aca?iia?aeiioaiue o
a?eueoino? oai?eo. Iiceoeaiee ee?i?/iee aoaeo e?eoaaiiy i?ney
i?iaaaeaieo eo?n?a niinoa??aaany o 93,3% aeiaaee?a. ?acoeueoaoe
aeine?aeaeaiue ai?iaaaeaeai? a ?iaioo e?eoaaeueieo caeeaae?a i?aaeiy
Oe?a?ie.

Eeth/ia? neiaa: o?ii?/iee naeuei?iaiioi?eo, iie?ii?oiiyaea?i?
eaeeioeeoe, aaeaioiaaie, oeaieiia oa?ai?y, ia?aiie?i?ae, oeeoio?i?/i?
iaoiaee aeine?aeaeaiiy, ai?iiie ia?eoa?e/ii? e?ia?, aacie?aeaey.

V.V. Malyuk. Complex therapy of chronic inflammation diseases, of the
uterus appendages (experimental-clinical research). – Manuscript.

Thesis for scientific degree of the candidate of medical sciences in
speciality 14.01.01 – Obstetrics and Gynaecology. — Odessa State Medical
University, Ministry of Health Case of Ukraine. — Odessa, 1998.

The dissertation is dedicated to the chronic inflammation desenses of
the uterus appendages. The treatment is based on the usage of
marepolimiel.

Based on the series of tests and studying of the functional
?olymorphicneucleous leukocytes with the help of citochemical methods,
we can state the positive influence of the complex therapy with the
usage of marepolimiel on nouspecific resistance of an organism under the
different clinical forms of inflammation process. As a result of the
research of the pituitary thyroadenite regulation it is ascertained that
the different cousistences of the pituitary – ovary – thyroadenite
hormone and cortisole are seen in different clinical forms of the course
of chronic salpingoophoritis.

Most Patients show the normalisation of the normal interactions, with
the introduction of marepolimiel info their treatment. The positive
clinical effect of the treatment after the course of therapy was
observed in 93,3 percent of cases. The results of the research were
included into the work of hospitals/medical centres in the South
Ukraine.

Key words: chronic salpingoophoritis, polymorphicneucleous leukocyte,
tela therapy, adoptivegene, marepolimiel, citochemical methods of
research, peripheral blood hormone, sterility.

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