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I?I?NOA?NOAI IOI?IIE CAeI?IAss OE?A?IE

OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO IIEIEIA?? OA ?AAe?IEIA??

Ia i?aao ?oeiieno

Ei?/einueea Ienaia ?aai?aia

OAeE 616.12:612.173.1-085:615.849

Eiiieaenia ?aae?iioee?aeia ioe?iea noaio i?iea?aea

a ae?aaiinoeoe? oa e?eoaaii? caoai?thaaiue

na?oeaai-noaeeiii? nenoaie

14.01.23 –i?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a –1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ?inoeooo? ea?ae?ieia?? ?i. I.Ae. No?aaeanea AII Oe?a?ie
.

Iaoeiaee eiinoeueoaio:aeieoi? iaaee/ieo iaoe, i?ioani? Ia/ia Ae.N.,
caa?aeoth/ee eaoaae?ith iaaee/ii? ?aae?ieia?? Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?,

Oeoe?ia A.A., caa?aeoth/a a?aeae?eaiiyi ?aae?aoe?eii?

iieieia?? ? yaea?ii? iaaeeoeeie Oe?a?inueeiai

IAe? iieieia?? ? ?aae?ieia?? IIC Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?

Neaaiia A.I., i?ia?aeiee iaoeiaee ni?a?ia?oiee eaai?aoi???

?aae?ieia?? IAe? aiaeie?eiieia?? ? iai?io ?a/iaei ?i. A.I. Eii?na?aiea

AII Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?,

Nieiiaiei ?.I., caa?aeoth/ee eaoaae?ith oi?aae?iiy ioi?iiith

caei?iay Oe?a?inueei? aeaaeai?? oi?aae?iiy i?e I?aceaeaioia? Oe?a?ie

I?ia?aeia onoaiiaa — Oa?e?anueeee iaoeiai-aeine?aeiee ?inoeooo
iaaee/ii? ?aae?ieia?? ?i. N.I. A?eai?? aa

Caoeno a?aeaoaeaoueny “ 16“ a?oaeiy 1999 ?. i 10 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.619.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? iieieia?? oa ?aae?ieia?? IIC Oe?a?ie.(
252022 i. Ee?a. Aoe. Eiiiiiniaa 33/43)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo .

Aaoi?aoa?ao ?ic?neaiee “ 12“ eenoiiaaea 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe Aeeeai ?.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue

Na?aae iaeaaaeeea?oeo caaaeaiue i?aeoe/ii? ioi?iie caei?ia’y i?ia?aeia
i?noea iin?aea? nai?/ania ae?aaiinoeea ? aaeaeaaoia e?eoaaiiy oaeeo
iaea?eueo iioe?aieo na?oeaai-noaeeiieo caoai?thaaiue, ye ?oai?/ia
oai?iaa na?oey, a?ia?oii?/ia oai?iaa, eaaaiaaa na?oea. ( Ieaenaiae?ia
I.E.,1992; Ane?aaeyi ?.N.,1994; Aia?ia A.I.,1995; Aiae?ia A.A.,1997;
A?c?? I.Ae.,1998; Borges-Neto S, 1993; Ferreria Montego IJ, 1995; Frank
H,1997).

No/ania iaaeeoeeia aenieeo oaoiieia?e cia/ii ?icoe?eea iiaeeeaino?
?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy. A aeaiee /an, ii?yae c oaeeie
caaaeueiiaeciaieie iaoiaeaie aeine?aeaeaiiy na?oey, ye ?aiaaieiio?ania
aaio?eeoeia?ao?y c ciiaeoaaiiyi iaa?no?aeueieo noaeei ? ii?iaeiei
na?oey (Neglia D,1987; Metcalfe M,1993), ?icaeaa?oueny oe?eee eiiieaen
ia?iaaceaieo iaoiae?a aeine?aeaeaiiy, ye? aeathoue aeinoaoiuei iaae?eio
? o?c?ieia?/ii ei?aeoio ?ioi?iaoe?th i?i ooieoe?iiaeueiee noai na?oey
(Iooa?eyiia I.I.,1981; A?aae?e?n TH.TH.,1987; Ei?ae I.A. 1989; Oae?an
I.A., 1995; Nakashima Y.,1993; Baur J.H.,1996; Gottsauer-Wolf
Michael,1996; E. Subhash,1997). Ca?aae inoaii?o /?eueia i?noea
caeiathoue iaoiaee ?aae?i?iaeeeaoe??, aeei?enoaiiy yeeo a ea?ae?ieia??
eaea ii o?ueio iniiaieo iai?yieao: ioe?iea nei?ioeeai? ooieoe?? na?oey;
cia?aaeaiiy ii?ooaiue ia?ooc?? i?iea?aea c e?euee?niith ?o
oa?aeoa?enoeeith; noeeio?a?ao?/ia aeyaeaiiy iae?ico na?oeaaiai i’yco ?
iino?ioa?eoieo ?oaoeaaeo ci?i oa aiaa?eci na?oey ( Na?a??iei A.A.,1987;

Oeeaaieia A.O.,1988; Ethaeae?n TH, 1989; E?oiaiia TH.A.,1997;Aeaniaa ?
.N., 1998; Iriarte Ezkurdia MM,1995; Moralidis E.,1998).

?aae?iioee?aeia aaio?eeoeia?ao?y, ye ia’?eoeaiee, aeniei?ioi?iaoeaiee
oa ao?aaiaoe/iee niin?a aeine?aeaeaiiy, noaa iaoiaeii aeai?o i?e
ae??oaii? i?iaeai ia?oiai iai?yieo, a naia — ye?niiai ? e?euee?niiai
aea/aiiy nei?ioeeai? ooieoe?? na?oey, ye a noai? niieith, oae ? i?e
??ciiiai?oieo ooieoe?iiaeueieo oa oa?iaeieia?/ieo oanoao (E?aia?
A.I.,1986; Iaeia I.A., 1990; Eoiaiia A.I.,1998; Shishido T,1993;
Takeishi Y,1994; Gunning MG, 1996; Klainman E.,1998). Iaeiae, ia
aeeaey/enue ia oe?iea aeei?enoaiiy aaio?eeoeia?ao??, iiaeeeaino? ??
aeaeaei ia ae/a?iai?.

Aea/aiiy noaio i?iaeaie a e?oa?aoo?? aeaei iiaeeea?noue aeae?eeoe
iaae??oai? ieoaiiy:

— i?aeoe/ii a?aenooi?e eiiieaeniee i?aeo?ae aei ioe?iee ?ioaa?aeueii?
ooieoe?? na?oey ca aeaieie ?IAA, c aeei?enoaiiyi noeoiiino? e?euee?nieo
e?eoa???a, ye? a?aeia?aaeathoue neeia?, ia’?ii?, oaeaee?ni? oa /ania?
eiiiiiaioe na?oeaaiai nei?i/aiiy;

— iaei ?ic?iaeai? niiniae ioe?iee no?oeoo?e ae?anoiee, cia/aiiy
ii?ooaiue yei? noa? ana a?eueo aaaeeeaei i?e aea/aii? iaoai?ci?a
ii?ooaiue i?iea?aea i?e ??cieo na?oeaai-noaeeiieo caoai?thaaiiyo;

— a?aenooi?e ?aeeiee i?aeo?ae aei ioe?iee ?aa?iia?ieo ii?ooaiue
nei?ioeeaino? i?iea?aea. Ia ae??oaia ieoaiiy i?i ae?aaiinoe/io
oe?ii?noue ??cieo e?eoa???a eieaeueii? nei?ioeeaino?, iiaeeea?noue
aeyaeaiiy cii aneia?a??, a oaeiae i?iaaaeaiiy oii?/iiai aiae?co;

— ca aeiyoeii aecia/aiiy caaaeueii? o?aeoe?? aeeeaeo, ?IAA ia
aeei?enoiao?oueny aeey ioe?iee ooieoe?iiaeueiiai noaio i?aaiai oeoii/ea
na?oey;

— iaaeinoaoiuei aeei?enoaiee aeey ?icoe?aiiy iiaeeeainoae ?IAA
iaoaiaoe/iee aiae?c ??cii? neeaaeiino?, a naia iiaeaethaaiiy ia iniia?
eiiieaeno ia?aiao??a noaio i?iea?aea i?e ??cieo caoai?thaaiiyo
na?oeaai-noaeeiii? nenoaie;

— ia caaa?oaia ?ic?iaea ?aae?iioee?aeii? nai?ioeee o?aaeaiue i?iea?aea
i?e na?oeaai-noaeeiieo caoai?thaaiiyo.

Iaaaeyeiai cia/aiiy a no/anieo oiiaao iaaoaa? ? aeiiii?/ia neeaaeiaa
iaoiae?a ianoaaeaiiy a ae?aaiinoe/iiio i?ioean? ( Gal R.A.,1992; Mark
D.B., 1996; Ino?ioiia ?.I.,1998). Aeoiaey/e c aeuaaeacaiiai, ie aaaaeaee
ca aeioe?eueia aeei?enoaoe noai?aiee ? ai?iaiaaiee a eaai?aoi???
?aae?i?cioiiieo iaoiae?a aeine?aeaeaiiy eiiieaen ia?aiao??a
?aae?iioee?aeii? aaio?eeoeia?ao?? aeey ioe?iee ooieoe?iiaeueiiai noaio
i?iea?aea i?e ??cieo na?oeaai-noaeeiieo caoai?thaaiiyo, ?ic?iaee ?
ooi/iaiiy ?aae?iioee?aeii? nai?ioeee o?aaeaiue na?oeaaiai i’yco ?
noai?aiiy iiaeae? aeey eiiieaenii? ioe?iee ea?ae?aeueii? ooieoe??,
?aca?a?a na?oey oa aoaeoeaiino? oa?ai?? eiai caoai?thaaiue.

Ca’ycie ?iaioe c iaoeiaeie oaiaie

Aeeiiaia ?iaioa ? /anoeiith iaoeiai? oaiaoeee eaai?aoi???
?aae?i?cioiiieo iaoiae?a aeine?aeaeaiiy oa a?aeae?eaiue anaioe?aeueii?
a?ia?oaic??, o?ii?/ii? ?oai?/ii? oai?iae ? a?eoi?e na?oey ?inoeoooo
ea?ae?ieia?? ?i. aeaae.I.Ae.No?aaeanea AII Oe?a?ie.I?aaenoaaeai? a
aeai?e ?iaio? aeine?aeaeaiiy aeei?enoai? a iaoeiaeo oaiao eaoaae?e
oa?ai?? noiiaoieia?/iiai oaeoeueoaoo Ee?anueeiai iaoe?iiaeueiiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey, eaoaae?e
iaaee/ii? ?aae?ieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe ?i.I.E.Ooieea, eaoaae?e ?aiaaiieia?? ? ?aae?ieia?? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.I.Ai?ueeiai.

Iaoa ?iaioe

Noai?aiiy iiaiai iaoiaee/iiai i?aeoiaeo aei ioe?iee ?acoeueoao?a
?aae?iioee?aeiiai aeine?aeaeaiiy na?oey ia iniia? ?icoe?aiiy,
iaa?oiooaaiiy oa noaiaea?oecaoe?? iaiao?aeieo ? aeioe?eueieo e?eoa???a
noaio ?ioaa?aeueii? ooieoe?? i?iea?aea, a oaeiae iiaoaeiaa
?aae?iioee?aeii? iiaeae? eiiieaenii? ioe?iee noaio i?iea?aea i?aaeo ?
e?aeo a?aeae?e?a na?oey i?e ??cieo na?oeaai-noaeeiieo caoai?thaaiiyo.

Caaaeaiiy aeine?aeaeaiiy

1. ?ic?iaeoe iia? iaoiaee/i? i?aeoiaee aeey ioe?iee aioo??oiueina?oeaai?
aaiiaeeiai?ee, aeeth/ath/e nenoie?/io ? ae?anoie?/io ooieoe?th
i?iea?aea, ia iniia? ?aae?iioee?aeii? aaio?eeoeia?ao??.

2. Aei?iaoaaoe niin?a ?aae?iioee?aeiiai aeine?aeaeaiiy ooieoe?? i?aaiai
oeoii/ea na?oey.

3. Canoiniaoth/e noai?aiee eiiieaen ia?aiao??a ?aae?iioee?aeii?
aaio?eeoeia?ao??, aea/eoe iniaeeaino? ?aiiaeaethaaiiy ooieoe?? i?iea?aea
o oai?eo ia ?ON aei ? i?ney o??o?a?/ii? ei?aeoe?? a?ioeaaiai
e?iaiieeio, a?ia?oii?/io oai?iao ??cieo noaae?e, o?ii?/ia eaaaiaaa
na?oea c eaaaiaai-na?oeaaith iaaeinoaoi?noth ??cii? aaaeeino?,
?ao?aeoa?ieie oao?a?eoi?yie ??ciiai iioiaeaeaiiy.

4. Ia iniia? ni?anoaaeaiiy aecia/eoe ee?i?/ii-ae?aaiinoe/io oe?ii?noue
oa ?ioi?iaoeai?noue iieaciee?a ?IAA a ii??aiyii? c ?ioeie
?ino?oiaioaeueieie iaoiaeaie aeine?aeaeaiiy i?iea?aea i?e ??cieo
caoai?thaaiiyo na?oeaai-noaeeiii? nenoaie.

5. ?ic?iaeoe ?aae?iioee?aeio nai?ioeeo ooeiaeaeaiue i?iea?aea,
a?aoiaoth/e ii?aeiaiee aiae?c ooieoe?iiaeueiiai noaio i?aaeo ? e?aeo
a?aeae?e?a na?oey, a oaeiae e?eoa??? ioe?iee aoaeoeaiino? e?eoaaiiy.

6. Aeei?enoiaoth/e iaoaiaoe/i? niiniae o?c?ieia?/ii? ?ioa?i?aoaoe??
aeaieo ?IAA, noai?eoe ?aae?iioee?aeio iiaeaeue eiiieaenii? ioe?iee noaio
i?iea?aea.

Iaoeiaa iiaecia ?iaioe

Aia?oa ia iniia? noai?aiiai eiiieaeno ia?aiao??a ?aae?iioee?aeii?
aaio?eeoeia?ao?? i?iaaaeaia iaea?eueo iiaia e?euee?nia ioe?iea
nei?ioeeai? ooieoe?? i?iea?aea ? eiai ae?anoie?/iiai
iaiiaiaiiy.Aecia/aia /ooeea?noue, ?ioi?iaoeai?noue oa a?aeoai?thaai?noue
ia?aiao??a ?IAA, i?iaaaeaia aa?eo?eaoe?y iniiaieo iieaciee?a c aeaieie
?aiaaieiio?anii? aaio?eeoeia?ao??. ?ic?iaeaiee niin?a aeine?aeaeaiiy
ia??iaeo ae?anoiee, yeee aeicaiey? iaea?aeoaaoe oaeaee?ni? oa ia’?ii?
iieacieee iaiiaiaiiy. C iaoith ?icoe?aiiy ?ioi?iaoeaiino? ?IAA a
ioe?ioe? ae?anoie?/ii? ooieoe?? i?iea?aea, noai?aiee aeai?eoi aecia/aiiy
o?aeoe?? iaiiaiaiiy ia?oi? ? ae?oai? o?aoeie ae?anoiee c ianooiiei
?ic?aooieii ae?anoie?/ieo ia’?i?a ia?oi? ? ae?oai? o?aoeie ae?anoiee
a?aeiia?aeii.

?icoe?aiee eiiieaen ia?aiao??a ?IAA ai?iaiaaiee i?e aea/aii?
?aiiaeaethaaiiy nei?ioeeai? ooieoe?? i?iea?aea i?e ?ON, a?ia?oii?/i?e
oai?ia?, ii?ooaiiyo ?eoio na?oey. Aia?oa ?IAA aeei?enoaia i?e
aeeiai?/ieo niinoa?aaeaiiyo a i?ioean? o??o?a?/iiai e?eoaaiiy oai?eo ia
?ON.

Noai?aiee eiiieaen ia?aiao??a ?IAA aia?oa canoiniaaiee a iiaiiio
ia’?i? aeey aiae?co aeaieo i?aai? aaio?eeoeia?ao?? ? ii?aeiaii? ioe?iee
ooieoe?iiaeueiiai noaio i?aaiai oa e?aiai oeoii/ea na?oey i?e
eaaaiaai-na?oeaa?e iaaeinoaoiino? ??cii? ae?aaeaiino?. Ooi/iaia, c
a?aooaaiiyi nenoiei-ae?anoie?/ieo oa?aeoa?enoee, ?aae?iioee?aeia
nai?ioeea o?ii?/iiai eaaaiaaiai na?oey.

Aia?oa ia iniia? eiiieaeno iieaciee?a ?IAA noai?aia iaoaiaoe/ia
iiaeaeue aeey ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea i?e iaea?eueo
iioe?aieo caoai?thaaiiyo na?oeaai-noaeeiii? nenoaie.

I?aeoe/ia cia/ei?noue ?iaioe

1.Aeei?enoaiiy ?acoeueoao?a ?iaioe aeicaieeoue a?eueo aeiiiiii,
canoiniaoth/e iaeei iaoiae aeine?aeaeaiiy, ioe?ieoe ooieoe?iiaeueiee
noai i?iea?aea, aeeth/ath/e nenoie?/io oa ae?anoie?/io oa?aeoa?enoeee.

2. Aeicaieeoue a?eueo aeeaiei aea/eoe no?oeoo?o ae?anoiee ia iniia?
aeae?eaiiy ie?aieo ?? oac ? aecia/aiiy neeiaeo oa ia’?iieo ia?aiao??a
ae?anoie?/iiai iaiiaiaiiy.

3. Aeanoue iiaeeea?noue aeae?eeoe ? iaa?oiooaaoe e?eoa??? ioe?iee
aoaeoeaiino? o??o?a?/iiai e?eoaaiiy ?oai?/ii? oai?iae na?oey.

4.?ic?iaeai? iaoiaee/i? i?aeoiaee aeey aea/aiiy ooieoe?iiaeueiiai noaio
i?aaiai na?oey caaacia/eoue iiaeeea?noue ii?aeiaii? ae?aaiinoeee
ii?ooaiue i?iea?aea ia eeoa i?e na?oeaaeo caoai?thaaiiyo, aea ? oaeeo
aaaeeeo noaiao ye eaaaiaai-na?oeaaa iaaeinoaoi?noue.

5. ?acoeueoaoe iiaeaethaaiiy ia iniia? ia?aiao??a ?IAA aeicaieeoue
i?iaiicoaaoe ii?ooaiiy ooieoe?? i?iea?aea i?e iniiaieo
na?oeaai-noaeeiieo caoai?thaaiiyo.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy

?acoeueoaoe ?iaioe ai?iaaaeaeai? a ?aae?i?cioiii?e eaai?aoi??? oa
a?aeae?eaii? ea?ae?ieia?? Aeiiaoeueei? iaeanii? ee?i?/ii? e?ea?i?
?i.Eae?i?ia, ea?ae?ieia?/iiio a?aeae?eaii? i?nueei? e?ea?i? ? 2
i.?aaii-O?aie?anueea, a?aeae?eaiiyo ea?ae?ieia?? oa ioeueiiiieia?? 3-?
ee?i?/ii? e?ea?i? i.Ee?aa, a iaaeaaia?/iee i?ioean a Aeiiaoeueeiio
iaaee/iiio oi?aa?neoao?, ?aaii-O?aie?anuee?e iaaee/i?e aeaaeai??, ia
eaoaae?? oa?ai?? noiiaoieia?/iiai oaeoeueoaoo Ee?anueeiai
iaoe?iiaeueiiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i.I.I.Aiaiiieueoey, ee?i?/ieo a?aeae?eaiiyo ?inoeoooo ea?ae?ieia?? ?i.
aeaae. I.Ae.No?aaeanea.AII Oe?a?ie.

Iniaenoee aianie aaoi?a

Aaoi?ii iniaenoi a eaai?aoi??? ?aae?i?cioiiieo iaoiae?a aeine?aeaeaiiy
?inoeoooo ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea AII Oe?a?ie i?iaaaeai?
?aae?iioee?aei? aaio?eeoeia?ao?? o an?o ianoaaeaieo oai?eo, ui
ciaoiaeeeenue ia noaoe?iia?iiio e?eoaaii? a ee?i?/ieo a?aeae?eaiiyo
?inoeoooo oa a?aeae?eaii? ioeueiiiieia?? 3-? ee?i?/ii? e?ea?i? i.Ee?aa ?
aa?eoee a a?oio niinoa?aaeaiiy. Iniaenoi i?iaaaeai? eiii’thoa?ia ia?iaea
? aiae?c iaea?aeaieo ?acoeueoao?a. Iaoaiaoe/ia iiaeaethaaiiy ia iniia?
eiiieaeno ia?aiao??a ?IAA i?iaaaeai? o a?aeae?e? i?eeeaaeiiai
iae?i?eiiai aiae?co ?inoeoooo i?eeeaaeiiai nenoaiiiai aiae?co AI Oe?a?ie
?acii c? noa?oei iaoeiaei ni?a?ia?oieeii a?aeae?eo, eaiaeeaeaoii
oaoi?/ieo iaoe Aneueiiiaith O.?.

Ai?iaaoe?y ?iaioe

Aeena?oaoe?eia ?iaioa caneooaia ia ?icoe?aiiio can?aeaii? eaoaae?e
iaaee/ii? ?aae?ieia?? EIAII ?i.Ooieea. Iniiai? iieiaeaiiy ? ?acoeueoaoe
?iaioe aeiiia?aeaeenue ? iaaiai?thaaeenue ia O?? Ananithciiio c’?cae?
?aiaaiieia?a ? ?aae?ieia?a ( Eai?ia?aae,1991); Ananithciiio neiiic?oi?
“?aaeeiioeeeaeiua enneaaeiaaiey a ea?aeeieiaee”(Iineaa, 1991);
eiioa?aioe??

?aae?ieia?a Oe?a?ie (Ee?a,1991); iaoeiai-i?aeoe/i?e eiioa?aioe??
“Eo/aaua iaoiaeu aeeaaiinoeee a ea?aeeieiaee” (Oiine,1992), IV Eiia?an?
Na?oiai? Oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa (Oa?e?a,1992);
I?aeia?iaeiiio Neia’yinueeiio eiia?an? ii aeaeo?inoeioeyoe?? ? ee?i?/i?e
aeaeo?io?c?ieia?? na?oey (N.-Iaoa?ao?a, 1993) ?anioae?eainuee?e iaoeia?e
eiioa?aioe?? “Aeooaeuei? ieoaiiy iaoiaaiaco, ae?aaiinoeee ? e?eoaaiiy
aoa?ineea?ico ? ?oai?/ii? oai?iae na?oey” (Oa?e?a,1994);Oe?a?inueeiio
eiia?an? ?aae?ieia?a (Ee?a,1995); ?anioae?eainuee?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Ea?ae?iaaneoey?ia ?aae?ieia?y”(Oa?e?a 1997);
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Ea?ae?iaaneoey?ia oa ?ioa?aaioe?eia
?aae?ieia?y.Eiio?ani? ?a/iaeie”(i.Neia’yinuee, 1998).

No?oeoo?a oa ia’?i aeena?oaoe??

Aeena?oaoe?y aeeeaaeaia ia noi??ieao iaoeiiieno, neeaaea?oueny ?c
anooio, i’yoe ?icae?e?a, iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiiy,
aeniiae?a ? nieneo aeei?enoaieo aeaea?ae e?oa?aoo?e ( ), a oiio
/ene? a?o/eciyieo aaoi??a. ?iaioa ?ethno?iaaia oaaeeoeyie ?
?enoieaie.

Ioae?eaoe??

?acoeueoaoe ?iaioe i?aaenoaaeai? o 25 noaooyo, a iaoeiaeo aeo?iaeao oa
ca??ieeao iaoeiaeo i?aoeue, 27 iaoa??aeao ? oacao oe?a?inueeeo oa
i?aeia?iaeieo eiioa?aioe?e ? eiia?an?a.

CI?NO ?IAIOE

Caaaeueia oa?aeoa?enoeea ianoaaeaieo oai?eo

? iaoiae?a aeine?aeaeaiiy

Aeey aeinyaiaiiy iniiaii? iaoe ?iaioe ianoaaeaii aeae?eueea a?oi oai?eo
caaaeueiith /enaeuei?noth 610 c ??cieie ca iioiaeaeaiiyi ? ae?aaeai?noth
i?iyaaie i?iea?ae?aeueii? iaaeinoaoiino? (oaae. 1).

Oaaeeoey 1

No?oeoo?a a?oie ianoaaeaiiy a caeaaeiino? a?ae

ee?i?/iiai
ae?aaiico

?:A?oie ianoaaeaiiyE?euee?noue oai?eo1Oai?? c ?oai?/iith oai?iaith
na?oey216a oiio /ene?:noaiiea?ae?y ?? o.ee.28??? o.ee.54IV
o.ee.182Oai?? c a?ia?oii?/iith oai?iaith120a oiio /ene?:? no.
A?ia?oii?/ii? oai?iae30?? no.a?ia?oii?/ii? oai?iae903Oai?? c
eaaaiaai-na?oeaaith iaaeinoaoi?noth90a oiio /ene?:ii/aoeiaa noaae?y43?
noaae?y35?? noaae?y124Oai?? c ?ao?aeoa?ieie ii?ooaiiyie ?eoio185Oai?? c
ii?iaeueiith /ooeea?noth i aioea?eoie/ieo
i?aia?ao?a20ia oii? aoa?ineea?ioe/iiai ea?ae?ineea?ico71ia oii?
i?iea?aeeoe/iiai ea?ae?ineea?ico114 Ia?oo a?oio neeaee oai?? c
?oai?/iith oai?iaith na?oey (?ON) ??-IV ooieoe?iiaeueieo eean?a (o.ee.)
ca eeaneo?eaoe??th AEIOe, 1982 ?., ioae/eie a a?oe? a?ae 37 aei 60
?ie?a, ui ia?aianee ai?oi-a?ioeaaa ooiooaaiiy (AAO). Ianoaaeaiiy oai?eo
i?iaiaeeeinue aei ? i?ney o??o?a?/ii? ei?aeoe?? ei?iia?iiai e?iaiieeio.
Na?aae iaoe??io?a noaiiea?ae?y ?? o.ee. ae?aaiinoiaaia o 23,6 % . ???
o.ee. — o 54,7%, IV o.ee. — o 21,7%.

Aei ?aae?iioee?aeii? aaio?eeoeia?ao?? (?IAA) ? i?ae /an ?? i?iaaaeaiiy
oai?? iaea?aeoaaee eeoa i?o?iae?oea?ei noae?iaaaeueii aeey ciyooy
aia?iicieo i?enooi?a. Iiaoi?ia ?IAA i?iaiaeeeanue i?ae /an ianooiii?
aini?oae?caoe?? oai?iai o a?aeae?eaiiy o?ii?/ii? ?oai?/ii? oai?iae
na?oey ?inoeoooo ea?ae?ieia?? /a?ac i?nyoeue i?ney AAO.

Aei neeaaeo ?? a?oie oa?eoee 120 oai?eo, ye? ciaoiaeeeenue ia
noaoe?iia?iiio e?eoaaii? o a?aeae?eaii? a?ia?oii?/ii? oai?iae (AO). O
an?o oai?eo ae?aaiinoiaaia AO ?-?? noaae?e. ? noaae?y aoea o 30 oai?eo,
?? — o 90. I?e aecia/aii? noaae?? caoai?thaaiiy ea?oaaeenue
eeaneo?eaoe??th AIIC (1978). Na?aaei?e a?e ianoaaeaieo — 43.3+ 2.1 ?ieo.
O?eaae?noue caoai?thaaiiy eieeaaeanue a?ae 1 ?ieo aei 20. Na?aae
ianoaaeaieo — 21 ae?iea, 99 — ioae/ei.

A ??? a?oio aa?eoei 90 oai?eo ia o?ii?/iee iano?oeoeaiee a?iio?o (OIA).
O a?oe? a?ae 35 aei 45 ?ie?a aoei 10 oai?eo (11,1%), a?ae 46 aei 55
?ie?a — 47 (52,2), a?ae 56 aei 65 — 33 (36.7%). On? oai?? /ieia?/ii?
noao?. O?eaae?noue caoai?thaaiiy a na?aaeiueiio noaiiaeea 8,8+0.62 ?ieo.
A caeaaeiino? a?ae nooiaiy aaaeeino? eaaaiaai-na?oeaai? iaaeinoaoiino?
(ENI) oai?? a ee?i?/i?e a?oi? ?iciiae?eeeenue ia o?e a?oie a?aeiia?aeii
c ii/aoeiaith ENI ( aeeoaeueia iaaeinoaoi?noue ? no. ca eeaneo?eaoe??th
I.?.Aeaiai ? na?oeaaa iaaeinoaoi?noue ?A no. ca eeaneo?eaoe??th
I.I.Iooa?eyiiaa ), ? no.ENI ( aeeoaeueia iaaeinoaoi?noue ?? no. ?
na?oeaaa iaaeinoaoi?noue ?A no.), ?? no.ENI ( aeeoaeueia iaaeinoaoi?noue
??? no. ? na?oeaaa iaaeinoaoi?noue ??A no.).

*aoaa?oo a?oio neeaee oai?? a e?eueeino? 185 in?a, ye? i?ieoee
ianoaaeaiiy ? e?eoaaiiy a a?aeae?eaii? a?eoi?e na?oey ?inoeoooo
ea?ae?ieia??. C ieo 145 ioae/ei ? 40 ae?iie. Ii?oieia?/iei noano?aoii
aeey aeieeiaiiy ii?ooaiiy ?eoio o 71 oai?iai aoea ?ON (
aoa?ineea?ioe/iee ea?ae?ineea?ic) ? o 114 oai?eo — i?iea?aeeoe/iee
ea?ae?ineea?ic. An? iaoe??ioe a?ae??ciyeenue oei, ui aoaeoeai?noue
aioo??oiueiaaiii aaaaeaieo i?aia?ao?a c /anii cieaeoaaeanue ?
?icaeaaeenue yaeua ?ao?aeoa?iino? aei aioea?eoi?/ieo i?aia?ao?a. I?e
ianoaaeaii? o 73 oai?eo aeyaeeanue iecueea /ooeea?noue, a o 112 — iiaia
a?aenooi?noue /ooeeaino? aei iaea?eueo aaeeaaieo aioea?eoi?/ieo
i?aia?ao?a. 185 oai?eo neeaee iniiaio a?oio, aeey ii??aiyeueiiai ae
aiae?co ianoaaeaii ua 20 oai?eo, /ooeeaeo aei aioea?eoi?/ii? oa?ai??,
ye? neeaee a?oio eiio?ieth (EA). Na?aaei?e a?e an?o ianoaaeaieo
a?aeiia?aeaa 41,5+0,98 ?ieo. O?eaae?noue “a?eoi?/iiai aaiaco” a iaio
a?oiao ii??aiyiiy a?aeiia?aeii eieeaaeanue a iaaeao 5.5+3.36 ? 4.27+0.5
?ieo.

Eiio?ieueio a?oio neeaee 20 caei?iaeo in?a /ieia?/i? noao? a a?eii a?ae
18 aei 60 ?ie?a ( na?aaei?e a?e 40.2+2.1 ?ieo).

?IAA i?iaiaeeeanue ca?aeii noaiaea?oii? iaoiaeeee, ?ic?iaeaii? Maddox
WJ et al (1978), ye a aeeiai?/iiio, oae ? noaoe/iiio aa??aioao caeaaeii
a?ae i?ioieieo ianoaaeaiiy. Aeei?enoiaoaaany eiiieaen aaia-eaia?e
LFOV-IV c eiii’thoa?ii PDP11/34a, a yeino? ?aae?ioa?ii?aia?ao?a — 99i
On-ia?oaoiaoao ? 99i On-i??oioao. I?ia?aiia caaacia/aiiy aeeth/aei o?e
i?ia?aie, ye? aeicaieyee iaea?aeoaaoe caaaeueio ? ?aa?iia?i? o?aeoe??
aeeeaeo e?aiai oeoii/eo na?oey. ?icoe?aiee eiiieaen ia?aioa??a ?IAA aeey
ioe?iee aioo??oiueina?oeaai? aaiiaeeiai?ee ? nei?ioeeai? ooieoe??
i?iea?aea noai?thaaany a eaai?aoi??? ?aae?i?cioiiieo iaoiae?a
aeine?aeaeaiiy ?inoeoooo ea?ae?ieia?? ?i.I.Ae.No?aaeanea i?ae
ea??aieoeoaii i?io. A.O.Oeeaaieiaa ca o/anoth aaoi?a aeaii? ?iaioe.
Noai?aiee eiiieaen aeei?enoaiee i?e i?iaaaeaii? ia o?eueee e?ai?, aea ?
i?aai? aaio?eeoeia?ao?? ? ai?iaiaaiee i?e ianoaaeaii? oai?eo c iciaeaie
ii?aaeaiiy i?aaiai oeoii/ea na?oey (?en.1.).

Noaoenoe/iee aiae?c aeaieo i?iaiaeeany c aeei?enoaiiyi oaeeo iaoiae?a:
ii??aiyiiy na?aaei?o aaee/ei, ioe?iea ??cieoe? ii??aithaaeueieo aaee/ei,
ae?aooaaiiy eiao?oe??io?a ei?aeyoe?? ? e?eoa???a t No’thaeaioa,
ii??aiyeueiee, ei?aeyoe?eiee, ?aa?aneaiee aiae?ce. Iiaeaethaaiiy, ui
aeeth/aei a naaa aea?? ??aiyiiy c aaeeeith e?euee?noth ia?aiao??a,
ioe?ieo naieo ia?aiao??a, oiaoi iiaoaeiao ?aa?aneaii? iiaeae?,
i?iaiaeeeinue o a?aeae?e? i?eeeaaeiiai iae?i?eiiai aiae?co ?inoeoooo
i?eeeaaeiiai nenoaiiiai aiae?co AI Oe?a?ie.

?acoeueoaoe aeine?aeaeaiiy

Iniiaith aeey noai?aiiy eiiieaeno ia?aiao??a ?IAA noaei iinooiiaa
?icoe?aiiy ia?ae?eo iieaciee?a ca ?aooiie ?ic?iaee i?ia?aiieo iaoiae?a
aecia/aiiy iniiaieo ooieoe?iiaeueieo oa?aeoa?enoee i?aaiai ? e?aiai
oeoii/e?a na?oey, a naia: na?oeaaeo ia’?i?a, aiie?ooaeieo ? /aniaeo
aaee/ei na?oeaaiai nei?i/aiiy, no?oeoo?e nenoiee ? ae?anoiee /a?ac
?ioaa?aeuei? ? ia’?ii? ia?aiao?e nei?ioeeaino? a ??ci? oace aeaiaiiy ?
iaiiaiaiiy.

Oai?aoe/ieie ia?aaeoiiaaie aeey ?ic?iaee iioeiaeueiiai eiiieaeno
ia?aiao??a ?IAA noaee ianooii? iieiaeaiiy. Ii-ia?oa, i?ia?aeiei
oaeoi?ii, yeee aecia/a? ?iaeea?aeoaeuei? iniaeeaino? ia?aa?ao
caoai?thaaiiy, iniaeeai ?ON, ? aaoa?iaaii?noue ii?ooaiiy nei?ioeeai?
ooieoe?? i?iea?aea e?aiai oeoii/ea na?oey ( ?.?.*acia, I.E.Oo?eaei).
Oea, c iaeiiai aieo, aecia/a? ?ioa?an aei iiaeeeaino? ia?iaaceaii?
ioe?iee ?ioaa?aeueii? ooieoe?? e?aiai oeoii/ea, c ae?oaiai — aei
iiaeeeaino? aiae?co no?oeoo?e oi?ioaaiiy oace aeaiaiiy c aeyaeaiiyi
?aa?iia?ieo aneia?a?e e?aiai oeoii/ea ( ?o eieae?caoe?y, iioe?ai?noue ?
oa?aeoa?). Ii-ae?oaa, ii??aiyeueiee aiae?c ?ioaa?aeueiiai iieacieea
nei?ioeeaino? ? ia’?i?a e?aiai oeoii/ea na?oey aeicaiey? ioe?ieoe oiiae
?aae?caoe?? ea?ae?aeueieo oaeoi??a eiiiainaoe?? a oiiaao ?ON, AO,ENI (
Oeeaaieia A.O.,Naoa?/oe ?.?.,?eueieoeueeee ?.?.). Ii-o?aoa,
aeiaaaeai?noue oiai oaeoo, ui i?aeoe/ii i?e an?o caoai?thaaiiyo
na?oeaai-noaeeiii? nenoaie iiaeooue aooe aeyaeai? ? aeyaeythoueny ?aii?
ci?ie ae?anoie?/ii? ooieoe?? i?iea?aea. A?eueoa oiai, ii?ooaiiy
ae?anoie?/ii? ooieoe?? iiaeooue iiai?noth aai /anoeiai a?aeiia?aeaoe ca
ci?ie nenoie?/ii? ooieoe?? (Ia??nii O.C.). ?, iae?iaoeue,
iaiao?aei?noue aea/aiiy ae?yeueiino? iaio oeoii/e?a na?oey a oiiaao
aoi?eiii? eaaaiaai? a?ia?oaic?? oa i?aeaeuaiiai eaaaiaaiai noaeeiiiai
iii?o i?e eaaaiaai-na?oeaa?e iaaeinoaoiino? (Ieaenaiae?ia I.E.,
Aiae?ia A.?.).

?IAA ia a?aei?io a?ae ?iaaceaieo iaoiae?a aeine?aeaeaiiy i?aeoe/ii ia
ia? iaiaaeaiue a iieacaiiyo aei i?iaaaeaiiy ?, ia onooiath/e ii
?ioi?iaoeaiino?, iiaea aooe aeei?enoaia ia naieo ?aii?o noaae?yo
caoai?thaaiiy, ye aeey ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea, oae ?
eiiiainaoi?ii-i?enoiniaieo iaoai?ci?a.

Ee?i?ei-o?c?ieia?/ii iaa?oioiaaiee, i?ia?aiii caaacia/aiee ?
aa?eo?eiaaiee eiiieaen ia?aiao??a ?IAA a iiaiiio ia’?i? aeeth/ea a naaa
ne?aeoth/? iieacieee:

· caaaeueia o?aeoe?y aeeeaeo oeoii/ea (e?aiai aai i?aaiai) — COA

· ia?aaeiuei-ia?aai?iaeeiaa o?aeoe?y aeeeaeo — IIOA

· caaeiuei-aieiaa o?aeoe?y aeeeaeo — CAOA

· 1-8 o?aeoe?? aeeeaeo naaiaio?a oeoii/ea — OA

· e?ioeaai-ae?anoie?/iee ia’?i — EAeI

· e?ioeaai-nenoie?/iee ia’?i — ENI

· oaea?iee ia’?i -OI

· na?aaeiuei-ii?iae?ciaaia oaeaee?noue nenoie?/iiai aeaiaiiy -NIONA

· iaeneiaeueia oaeaee?noue aeaiaiiy — OAi

· /an aeinyaiaiiy iaeneiaeueii? oaeaeeino? aeaiaiiy -O-OAi

· iaeneiaeueia oaeaee?noue iaiiaiaiiy — OIi

· /an aeinyaiaiiy iaeneiaeueii? oaeaeeino? iaiiaiaiiy -O-OIi

· o?aeoe?y iaiiaiaiiy 1/3 ae?anoiee -OI 1/3

· o?aeoe?y iaiiaiaiiy 2/3 ae?anoiee — OI 2/3

· ae?anoie?/iee ia’?i 1/3 ae?anoiee — AeI 1/3

· ae?anoie?/iee ia’?i 2/3 ae?anoiee — AeI 2/3

· /an aeaiaiiy — O aeai.

· oaeaee?noue aei?i/aiiy oee?eoey?ieo aieieii i?iea?aea- V cf

Ai?iaaoe?y noai?aiiai eiiieaeno ia?aiao?a ?IAA aoea i?iaaaeaia a
i?ioean? ianoaaeaiiy ? e?eoaaiiy oai?eo ia ?oai?/io oai?iao na?oey ( aei
? i?ney o??o?a?/ii? ei?aeoe?? ei?iia?iiai e?iaiieeio), a?ia?oii?/io
oai?iao, eaaaiaaa na?oea oa ?ao?aeoa?i? oao?a?eoi?? ??ciiai
iioiaeaeaiiy.

Ca aeaieie ?IAA aei ai?oi-a?ioeaaiai ooiooaaiiy o an?o ianoaaeaieo
oai?eo aaiiaeeiai?/ia i?iaeoeoeai?noue na?oey a noai? niieith aoea
caaeia?eueiith, ca aeiyoeii ae?anoie?/ieo iieaciee?a, aeinoia??ii
ci?iaieo o oai?eo c? noaiiea?ae??th niieith, ui aeacoaaei ia nooo?a?
ii?ooaiiy ea?ae?iaeeiai?ee ia aeiiia?aoe?eiiio aoai? (oaae.2).

Oaaeeoey 2

Ooieoe?iiaeueia oa?aeoa?enoeea aioo??oiueina?oeaai? aaiiaeeiai?ee
o ianoaaeaieo oai?eo c ?ON aei AAO ca aeaieie ?IAA

____________________________________________________________________

Iieacieee Oai?? c aneiioiiiei Oai?? c aieyie a
a?oaei?e

ia?aa?aii ?ON
ee?oei?

n = 36
n = 64______________

COA % 41,2 + 1,9 39,9 + 2,6

EAeI ni3 126,4+5,0 128,1+4,3

ENI ni3 75,2 +5,9 79,9+6,8

O I ni3 55,6+3,0 54,2+2,5

NIONA n-1 1,3 +0,15 1,26+0,1

OAi n-1 3,7+0,5 3,42
+0,4

O-OAi in 149,3+12,1 158,2+14,6

OIi n-1 2,32+0,11 1,16+0,13*

O-OIi in 176,1+12,8 228,2+16,7*

O aeai. in 286,0+14,7 298,3+12,6

V cf n-1 0,72+0,03
0,68+0,05

__________________________________________________________________

· — aeinoia??i?noue ??cieoe? ( P< 0.05) Aeey ia’?eoea?caoe?? ioe?iee i?iea?ae?aeueii? ooieoe?? an? ia?aiao?e aoee ?icaeyioo? a caeaaeiino? a?ae aaaeeino? caoai?thaaiiy ii i??? ?? ia?inoaiiy ( oaae.3). Oaaeeoey 3 Iniiai? iieacieee ea?ae?iaeeiai?ee o oai?eo c ?ON a caeaaeiino? a?ae aaaeeino? noaiiea?ae?? aei AAO ___________________________________________________________ Ia?aiao?e ?? o.ee. ??? o.ee. IV o.ee. n = 28 n = 54 n = 18__ CAO, % 51,2+1,9 49,1 +2,4 37,3 +5,6 P 2 <0.05 EAeI, ni 3 125+ 12,3 136+10,4 171 +11,7 P 2 < 0.05 ENI, ni 3 56,8+5,6 71,0+8,2 102 +12,9 P 1 < 0.05 P 2 < 0.05 OI, ni 3 74,7+4,9 65,0+6,4 59,6+5,8 P 1 < 0.05 ? 2 > 0.05

NIONA n -1 1,97+0,2 1,6+0.06
1,3+0.2

I?iaeiaaeaiiy oaae.3

P 1 > 0.05

P 2 > 0.05

Oai n-1 3,7+0,34 3,65+0,42
3,41+0,53

P 1 > 0.05

P 2 > 0.05

O-OAi nae 159,0+12,6 171,4+13,0
190,0+11,8

P 1 > 0.05

P 2 > 0.05

Oii n-1 1,9+0,4 1,74+0,6
1,62 +0,3

P 2 < 0.05 O-OIi inae 210,1+16,8 226,0+18,1 260,0+16,1 P 1 > 0.05

P 2 > 0.05

V cf c-1 1.29+ 0.07 1.09+0.06
0.64 +0.08

P 1 < 0.05 P 2 < 0.05 O aeai inae 318.0+ 20.1 321.0+18.7 362.0+16.9 P 1 > 0.05

P 2 > 0.05

___________________________________________________________

aea ? 1 — aeinoia??i?noue ??cieoe? ? ? ?? a?oi, ? 2 — aeinoia??i?noue
??cieoe? ?? ? ??? a?oi

O oai?eo ?-i? a?oie COA aeaui ia?aaeuoaaea 50%, a ??-e a?oi?
niinoa??aaeinue noaoenoe/ii cia/eia ciaioaiiy ?? na?aaeiuei? aaee/eie.
I?e oeueiio o 12 oai?eo c 54 ianoaaeaieo COA ciaoiaeeeanue a iaaeao a?ae
35 aei 45%. A o?ao?e a?oi? ia?inoaea ae?aaeai?noue oaiaeaioe?? aei
aeaeuei?oiai cieaeaiiy COA. A oe?e a?oi? o 12 iaoe??io?a aaee/eia COA
eieeaaeanue a i?ii?aeeo a?ae 25,3 aei 45% ? eeoa o 4 oai?eo — a iaaeao
aeua 45%. A?aei?/ai? aiaeia?/i? ci?ie oaeaee?nieo iieaciee?a nei?i/aiiy
— NIONA, V cf, Oai. I?e oeueiio,caa?oa? ia naaa oaaao, ia no?eueee
noaoenoe/ii cia/eia ca?eueoaiiy ??aiy ae?aaeaiino? ci?i, ne?eueee
c?inoaiiy e?eueeino? oai?eo c? cieaeaieie iieacieeaie o ae?oa?e ? o?ao?e
a?oiao a ii??aiyii? c ia?oith. Ne?ae oaeiae a?aei?oeoe, ui a aeayeeo
aeiaaeeao ( o 9 iaoe??io?a ia?oi? ? 16 — ae?oai? a?oi) niia?eueiaiiy
NIONA ? V cf ii?aeioaaeinue c aaee/eiaie COA, ui a?aeiia?aeaee
ii?iaeueiei. Oaea ni?aa?aeiioaiiy iiaeia ?icaeyaeaoe ye /anoeiaee aeieac
iayaiino? ii/aoeiaeo ci?i i?ioeano nenoie?/iiai aei?i/aiiy ?
i?aeoaa?aeaeaiiy oyaeaiiy i?i oa, ui oaeaee?ni? iieacieee ? /ooeeaeie
ia?ea?aie ii?ooaiue ooieoe?? e?aiai oeoii/ea. Aiie iiaeooue aooe ?aii?ie
iciaeaie ii?ooaiiy ooieoe?? i?iea?aea a ?acoeueoao? iaaeinoaoiino? eiai
e?iaiiinoa/aiiy.

Ci?ie EAeI ? ENI iineee a?eueo caeiiii??iee oa?aeoa?. Aaee/eie EAeI a
ia?o?e ? ae?oa?e a?oiao caa??aaeenue ia iaeiiio ??ai? ? nooo?ai ia
a?ae??ciyeenue a?ae ii?iaeueieo, a oie /an, eiee a o?ao?e a?oi? EAeI aoa
cia/ii a?eueoee a ii??aiyii? c iiia?aaei?ie aeaiia ( ? 1 <0.05, P 2 < 0.05).Oaiaeaioe?y aei c?inoaiiy aeyaeeanue a?eueo oa?aeoa?iith aeey ENI, oae ye o an?o a?oiao ianoaaeaieo niinoa??aaeenue a?eueo aenie?, a ii??aiyii? c eiio?ieai ? i?ae niaith, aaee/eie. A caaaeueiiio, aeeiai?ea ci?i na?oeaaeo ia’?i?a na?ae/eea i?i caa?aaeaiiy iaiao?aeii? aaiiaeeiai?/ii? i?iaeoeoeaiino? na?oey a noai? niieith o oai?eo ia?oi? ? ae?oai? oa i?i iiyao iciae iia??oaiiy ianinii? ? nei?ioeeai? ooieoe?? a o?ao?e a?oi?. Aeai? ?IAA, ye? oa?aeoa?ecothoue ae?anoie?/io ooieoe?th i?iea?aea, na?ae/aoue i?i aeinoia??ia ?? iia??oaiiy o an?o ianoaaeaieo.Ine?eueee, aeeiai?ea ?icneaaeaiiy /eieoue cia/iee aieea ia neeo iine?aeoth/iai nei?i/aiiy, oi a oiiaao iaoieia?? ?acoeueoaoii iaiiaiiai ?icneaaeaiiy i?iea?aea ( oaiiiai iacaaa?oaii? ae?anoiee ) ? i?aeaeuaiiy iai?oaeaiiy niieith ? ci?ie ae?anoie?/ieo aeanoeainoae i?iea?aea ( ia’?iii? i?aeaeaoeeaino? e?aiai oeoii/ea ). A ca’yceo c oeei, iniaeeaiai cia/aiiy iaaoaa? aeei?enoaiiy ?IAA aeey ioe?iee ae?anoie?/iiai iaiiaiaiiy /a?ac aecia/aiiy o?aeoe?e iaiiaiaiiy a ia?oo ? ae?oao o?aoeie ae?anoiee ? a?aeiia?aeieo ?i ia’?i?a. Ne?ae cacia/eoe, ui c iia??oaiiyi nei?ioeeai? ooieoe?? i?iea?aea ia?inoaee ci?ie ae?anoiee - a?aei?/aeinue cieaeaiiy OI 1/3 (oaae.4) Oaaeeoey 4 No?oeoo?a ae?anoiee o oai?eo c ?ON aei AAO _______________________________________________________________________ Ia?aiao?e : Eiio?ieue : Oai?? c ?ON c aieueiaei neiae?iiii (n =100) : n = 20 ?? o.ee. ??? o.ee. IV o.ee._____ OI 1/3 % 49.0+2.2 49.4+1.9 40.3+1.8* 36.9+1.3* OI 2/3 % 76.0+6.3 72.8+1.3 71.5+2.7 77.1+2.1* AeI 1/3 ni 3 89.4+4.1 85.8+3.1 97.6+2.14* 126.8+2.7* AeI 2/3 ni 3 105.6+3.8 106.3+2.8 117.1+2.3 * 155.6+2.9* *- aeinoia??i?noue ??cieoe? ?< 0.05 _________________________________________________________ . O?aeoe?y iaiiaiaiiy ae?oai? o?aoeie i?e oeueiio cia/eii ia ci?ithaaeanue, ui na?ae/eoue i?i ia?a?iciiae?e iaiiaiaiiy e?aiai oeoii/ea a iai?yieo a?eueo i?ciueiai iaiiaiaiiy ( ae?anoaceno). Aeacai? ci?ie a no?oeoo?? iaiiaiaiiy ii?aeiothoueny c? ciaioaiiyi iaeneiaeueii? oaeaeeino? iaiiaiaiiy ? iinyoue iaeiiiai?aaeaiee oa?aeoa?. Aiae?c AeI 1/3 ? AeI 2/3 iieacaa , ui aaee/eie oeeo iieaciee?a o an?o ianoaaeaieo cia/eii ia a?ae??ciythoueny i?ae niaith, aea ? cieaeaieie ii a?aeiioaiith aei eiio?ieueiiai ??aiy. E??i oiai, noaea i/aaeaeiith iaea ?ioi?iaoeai?noue oeeo ia?aiao??a, ye naiino?eieo iieaciee?a ae?anoie?/ii? ooieoe??. Aeey aeyaeaiiy ?o ?ie? a ii?ooaii? no?oeoo?e ae?anoiee a?eueo eia?/iei oyaey?oueny ni?anoaaeaiiy ia’?i?a iaiiaiaiiy c ENI oa EAeI a iine?aeiaiino?: ENI- AeI1/3-AeI 2/3- EAeI ( oaae. 5) Oaaeeoey 5 Ia’?ii? oa?aeoa?enoeee ae?anoiee o oai?eo c ?ON aei AAO ca aeaieie ?IAA ____________________________________________________________________ Ianoaaeai? ENI AeI 1/3 AeI 2/3 EAeI oai?? ni 3 ni 3 ni 3 ni 3 __________________________________________________________________ II o.ee. n=28 56.8+5.6 85.8+3.1 106.3+2.8 125.0+12.3 ??I o.ee. n=54 71.0+8.2 97.60+2.14 117.1+2.3 136.0+10.4 P 1 < 0.05 P 1 < 0.05 P 1 < 0.05 P 1 > 0.05

IV o.ee.n=18 102+12.9 117.1+2.3 155.6+2.9 171 +11.7

P 2 < 0.05 P 2 < 0.05 P 2 < 0.05 P 2 < 0.05 ___________________________________________________________ I?e ii??aiyii? ia’?i?a o ianoaaeaieo ? a?oie ? oai?eo c? noaiiea?ae??th ??? OE aeinoia??ii? ??cieoe? ia ciaeaeaii. Iaeiae, ii i??? ia?inoaiiy aaaeeino? caoai?thaaiiy, niinoa??aaeinue ca?eueoaiiy ia’?i?a, c iaeiiai aieo, a caeaaeiino? a?ae ooieoe?iiaeueiiai eeano, c ae?oaiai aieo, oea ca?eueoaiiy oa?aeoa?ecoaaeinue i?eaeecii iaeiaeiaei i?e?inoii eiaeiiai ia’?iiiai iieacieea ae?anoiee. Ci?ie ea?ae?iaeeiai?ee ii i??? ia?inoaiiy aaaeeino? caoai?thaaiiy iiaeia oyaeoe ne?aeoth/ei /eiii. Cieaeaiiy nei?ioeeai? caeaoiino? i?iea?aea aiane?aeie iaaeinoaoiueiai caaacia/aiiy eiai aia?aio?ao, ca’ycaiiai c iaiaaeaiiyi i?eoieo e?ia?, i?eaiaeeoue aei iaaeinoaoiueiai aeaiaiiy e?ia? c ii?iaeieie e?aiai oeoii/ea a ia??iae nenoiee ? ca?eueoaiiy caeeoeiaiai ia’?io a e?aiio oeoii/eo (ENI). Ana oea i?e iaci?iiiio aaiiciiio iiaa?iaii? aeeeeea? ca?eueoaiiy EAeI ? ca caeiiii O?aiea-Noa?e?iaa i?eaiaeeoue aei i?aeneeaiiy neee nei?i/aiiy e?aiai oeoii/ea ? i?aeo?eiaiiy oaea?iiai aeeeaeo oa o?aeoe?? aeeeaeo a ii?iaeueieo iaaeao. Iienaia noaae?y iia?e?caoe?? eiiiainaoi?ieo iaoai?ci?a iiaea oa?aeoa?ecoaaoeny ??ciei ii?aeiaiiyi e?euee?nieo oa?aeoa?enoee ooieoe?iiaeueieo ia’?i?a na?oey ( ca?eueoaiiy EAeI c iaci?iiei aai aeaui i?aeaeuaiei ENI) aea c ii?iaeueieie aaee/eiaie ianinii? ooieoe?? na?oey ? o?aeoe?? aeaiaiiy. Iiaeaeueoa cieaeaiiy nei?ioeeai? ooieoe?? na?oey aiane?aeie aeeaiei? ? o?eaaei? ?oai?? i?iea?aea, a?eueo iaoe?iiai o?aaeaiiy a?ioeaaeo noaeei cieaeo? ?aca?ai? iiaeeeaino? i?iea?aea ? cao?oaeith? ?aae?caoe?th iaeiiai c iniiaieo iaoai?ci?a eiiiainaoe?? - iaoai?cio O?aiea-Noa?e?iaa. Oaeei /eiii, aiae?c ni?aa?aeiioaiiy i?ae ooieoe?iiaeueieie ia’?iaie na?oey ? iieacieeaie ?ioaa?aeueii? nei?ioeeai? ooieoe?? i?iea?aea aeicaiey? ioe?ieoe nooi?iue o/ano? iniiaieo eiiiainaoi?ii-i?enoiniaieo iaoai?ci?a. Caaaeueii a?aeiii, ui a?ioeaaa e?iaiiinoa/aiiy ? iaei??th c iaeaaaeeea?oeo aeaoa?i?iaio nei?ioeeai? caeaoiino? i?iea?aea . Ciaioaiiy a?ioeaai? ia?ooc?? iaia’yceiai i?eaiaeeoue ia o?eueee aei noia?iiai cieaeaiiy ooieoe?iiaeueii? aeoeaiino? na?oey, aea ? aei aaoa?iaaiiiai ia?a?iciiae?eo ooieoe?? a i?iea?ae? . Aeoiaey/e c oeueiai, ioe?iea ?aa?iia?ii? aeenooieoe?? i?iea?aea e?aiai oeoii/ea iaaoaa? i?eioeeiiaiai cia/aiiy. sse aeaeii c ?enoiea 2, noai ?aa?iia?ii? nei?ioeeaino? ia oii? iica?/iiai o?aaeaiiy i?iea?aea aecia/a?oueny ia?a?iciiae?eii, coiiaeaiei iaiao?aei?noth noai?aiiy a eiaeiiio naaiaio? iaea?eueo iioeiaeueiiai noaio o aeaeyae? ooieoe?iiaeueii iaiao?aeiiai a?ia?- /e a?iie?iaco. Inoaiia na?ae/eoue i?i oa, ui eieaeuei? naaiaioe i?iea?aea ? aeniei/ooeeaeie ? oaeaeei ?aaaoth/eie no?oeoo?aie a oiiaao ci?iaii? ia?ooc?? i?iea?aea. Aiae?c nei?ioeeai? ooieoe?? ii o?ueio aiaoii?/ieo iaeanoyo aeyaea oaiaeaioe?th aei cieaeaiiy o?aeoe?? aeeeaeo ii i??? ia?inoaiiy aaaeeino? caoai?thaaiiy. ?icaeooy ia a?n?i cii aeicaieeei i?aeoaa?aeeoe oaiaeaioe?th aei i?ia?aneaiiai cieaeaiiy OA ii i??? ia?inoaiiy aaaeeino? caoai?thaaiiy c a?eueo oi/iith oa?aeoa?enoeeith eieae?caoe?? ? iioe?aiino? aeenneia?a?e. sseui i?eeiyoe a yeino? aeene?ei?iaoe?eiiai cia/aiiy 60 % aeey aa?o?aeiai? ciie ? 50 % - aeey ia?aaeiuei-ia?aai?iaeeiai? ? caaeiuei-aieiai?, oi a ianoaaeaieo oai?eo c?inoaea ye noai?iue ae?aaeaiino? ci?i aaee/ei o?aeoe?e aeeeaeo, oae ? e?euee?noue in?a, o yeeo aeyaeyeenue aaee/eie ieae/? aeacaieo cia/aiue ( a ae?oa?e ? o?ao?e a?oiao a ii??aiyii? c ia?oith P< 0.01). Iaeiae, ioe?iea e?eueeino? cii n ii?ooaiith nei?ioeeaith ooieoe??th, ?o eieae?caoe?? ? oa?aeoa?o ( a?ia?- a?ii- ? aeene?iac?? ) noaea iiaeeeaith eeoa i?e ii??aiyii? ie?aieo ?iaeea?aeoaeueieo aeiaaee?a. I?e oeueiio, eieae?caoe?y ii?ooaiue nei?ioeeai? ooieoe?? i?iea?aea ii ciiao, ia iineea caeiiii??iiai oa?aeoa?o, a?aeia?aaeath/e ?iaeea?aeoaeuei? iniaeeaino? o?aaeaiiy a?ioeaaeo noaeei ? aca?iica’ycie i?ae eieae?caoe??th inoaii?o ? noai?iith ?o ae?aaeaiino?. Ii??aithth/e iieacieee aioo??oiueina?oeaai? aaiiaeeiai?ee ? nei?ioeeaino? i?iea?aea aei ? i?ney AAO ne?ae a?aei?oeoe, ui aeinoia??ia iie?auaiiy ia?ooc?? i?iea?aea ia iiiaio aeine?aeaeaiiy, i/?eoaaiiai iioei?coth/iai aieeao ia nei?ioeea? ia?aiao?e ia iaei. Iaea?eueo ?iaeeeaoeaieie aeyaeeenue ia?aiao?e ae?anoie?/ii? oace na?oeaaiai nei?i/aiiy. Oae, cia/ii ca?eueoeeanue iaeneiaeueia oaeaee?noue iaiiaiaiiy e?aiai oeoii/ea, a oea, a naith /a?ao, i?eaaei aei nei?i/aiiy ia??iaeo ?? aeinyaiaiiy. Ci?ie ae?anoie?/ii? ooieoe?? oi?eioeenue ia eeoa aiie?ooaeieo ? /aniaeo iciae ae?anoiee, aea i?iyaeeenue ? a ia?aaoaeia? ?? no?oeoo?e ( oaae.6). Ii?yae c i?aeaeuaiiyi oaeaeeino? iaiiaiaiiy e?aiai oeoii/ea, yea a?aei?/aeinue i?ney AAO, aeinoia??ii c?inea o?aeoe?y iaiiaiaiiy ia?oi? o?aoeie ae?anoiee. Iioei?caoe?y oace oaeaeeiai iaiiaiaiiy noi?iaiaeaeoaaeanue ca?eueoaiiyi ia’?io iaiiaiaiiy a ia?oo o?aoeio ae?anoiee. Aiaeia?/ia iai?aaeai?noue ci?i aeyaeaia ? ii a?aeiioaiith aei oa?aeoa?enoee oace iia?eueiiai iaiiaiaiiy, a naia - OI 2/3 ? AeI 2/3. Caaaeii, oea na?ae/eoue i?i iayai?noue /?oei? oaiaeaioe?? aei iie?auaiiy i?ioean?a ?aeaenaoe?? ? iaiiaiaiiy ca ?aooiie i?aeneeaiiy iiaiioe ?icneaaeaiiy i?iea?aea, ca?eueoaiiy oaeaeeino? ? noaiai? iaiiaiaiiy ii?iaeieie e?aiai oeoii/ea, a oaeiae ii?iae?caoe?? ni?aa?aeiioaiiy “oene-ia’?i”. Oaaeeoey 6 Ia?aaoaeiaa no?oeoo?e ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea o oai?eo ?ON i?ae aieeaii AAO ____________________________________________________________________ Ia?aiao?e Aei AAO I?ney AAO ____________________________________________________________________ OI 1/3 % 44.7+2.0 56.1+1.8* OI 2/3 % 73.4+1.9 78.6+2.1 AeI 1/3 ni 3 86.3+2.7 94.3+1.6* AeI 2/3 ni3 105.6+2.9 122.7+3.4* OIi n-1 1.87+0.08 2.9 +0.05* O-OIi in 221.5+13.7 184.7+12.6* * - aeinoia??i?noue ??cieoe? ( P < 0.05) ________________________________________________________________________ _ Uiaei a ieeao AAO ia noai ?aa?iia?ii? nei?ioeeaino? e?aiai oeoii/ea, oi iaeii/anii c? c?inoaiiyi aaee/ei OA ie?aieo cii a?eueoa, i?ae ia 5%, a?aeaoaaany ia?a?iciiae?e i?ae niaith cii c a?eueo /e iaio aenieei cia/aiiyi OA. Oae? ci?ie iiae?ai? aei oeo, ye? aaea a?aei?/aeenue i?e ii??aiyii? iieaciee?a ?aa?iia?ii? nei?ioeeaino? o oai?eo ia ?ON ? in?a eiio?ieueii? a?oie. Iaeiae, oai oea na?ae/eei i?i aaoa?iaaii?noue o?aaeaiiy i?iea?aea i?e ?oai?/i?e oai?ia?, a aeaiiio ae aeiaaeeo ie ia?ii ni?aao c? ci?iith no?oeoo?e ?aa?iia?ii? nei?ioeeaino?, yea iineoue /?oei eiiiainaoi?iee oa?aeoa? ? ni?yiiaaia ia onoiaiiy aeene?iac?e ca ?aooiie aeinyaaiiy ooieoe?iiaeueii iaiao?aeiiai a?ii- /e a?ia?e?iaco. I?iaiae?coaaaoe oaeei /eiii noai nei?ioeeai? ooieoe?? i?iea?aea e?aiai oeoii/ea, iiaeia c?iaeoe aeniiaie, ui iioei?caoe?y ea?ae?iaeeiai?ee i?ney AAO a aaeee?e i??? caeaaeeoue a?ae aca?iica’yceo oa noaiai? a?aeiia?aeiino? iaeei iaeiiio ei?iia?iiai oa i?iea?ae?aeueiiai ?aca?a?a. Naia inoaii?e oaeoi? ? aecia/a? ??aaiue ooieoe?iioaaiiy i?iea?aea ia ??cieo aoaiao a?ae no?eei? eiiiainaoe?? /a?ac iaeneiaeueia iai?oaeaiiy i?enoiniaieo iaoai?ci?a aei aeniaaeaiiy ea?ae?aeueieo ooieoe?e. A?aoiaoth/e oe?ieee niaeo? ea?ae?aeueieo oaeoi??a, ye? oi?iothoue nooue neiae?iii-eiiieaeno “a?ia?oaiceaia na?oea”, eiiieaen ia?aiao??a ?IAA aoa aeei?enoaiee aeey iaii?aiii? ioe?iee noaio i?iea?aea o oai?eo c AO ??cieo noaae?e. O oai?eo c ? no.AO (oaae.7) caaaeueia ? eieaeuei? o?aeoe?? aeeeaeo e?aiai oeoii/ea, a oaeiae na?oeaa? ia’?ie nooo?ai ia a?ae??ciyeenue a?ae aaee/ei eiio?ieueii? a?oie. Oaaeeoey 7 Ooieoe?iiaeueiee noai i?iea?aea e?aiai oeoii/ea na?oey o oai?eo AO ??cieo noaae?e ____________________________________________________________________ Iieacieee Eiio?ieue: Oai?? AO________________ : ? noaae?y : ?? noaae?y n=10 : n=30 : n = 90_____ COA % 61.0+ 6.1 57.5+4.9 55.9+2.4 IIOA % 57.9+1.4 47.8+1.8 52.0+1.4 AOA % 75.8+4.8 74.+4.6 67.1+4.1 CAOA % 61.9+5.9 52.4+6.9 52.5+5.9 EAeI ni 3 121.0+5.3 110.0+10.3 131.0+7.4* ENI ni 3 45.0 +6.9 44.0+4.1 59.0+6.2* O I ni 3 77.3+ 6.4 71.3+7.2 67.0+6.1 V cf n-1 1.5+0.08 1.72+0.08* 1.02+0.03* OAi n-1 5.33+0.27 5.9+1.3* 4.42+0.9* O-OAi in 187+24 160+11.3 192+14.2 OI i n-1 3.33+0.8 4.0+0.6* 2.6+0.6* O-OI i in 166+23 150.6+11.2 189+ 10.5* O aeai.in 346+16.1 325+10.8 357+16.2 ___________________________________________________________ * - aeinoia??i?noue ??cieoe? ? < 0.05 Oaeaee?ni? iieacieee aeaiaiiy iaee oaiaeaioe?th aei i?aeaeuaiiy. O oai?eo ?? no.AO caaaeueia ? ?aa?iia?i? OA iaee iaeiiiai?aaeaio oaiaeaioe?th aei cieaeaiiy, aea na?aaei? cia/aiiy aaee/ei oeeo iieaciee?a ia aeinyaaee noaoenoe/ii? aeinoia??iino? i?e ii??aiyii? c eiio?ieai ? ianoaaeaieie c ? noaae??th. Ioe?iea e?eueeino? cii c ii?ooaiith nei?ioeea?noth aeyaeeanue iiaeeeaith eeoa i?e ni?anoaaeaii? ?iaeea?aeoaeueieo aaee/ei. I?e oeueiio, a?iie?iaoe/i? ciie aeyaeyeenue iaa?oue o oai?eo c ii?iaeueiith COA. Caaaeueieo aea caeiiii??iinoae ? noaoenoe/ii-aeinoia??ieo a?aei?iiinoae na?aaei?o aaee/ei OA anoaiiaeoe ia aaeaeinue. Iaea?eueo /?oe? ci?ie, ui iai?oeeenue ii a?aeiioaiith aei aa?o?aeiai? ciie e?aiai oeoii/ea, iaea??ia?aei?oa, iiyniththoueny oeiii a?ia?o?io?? i?iea?aea i?e AO ? oa?aeoa?ii ?? iioe?aiiy. ?acii c oei, ??cii??aei?noue aaee/ei nei?ioeeaino? aeaio ae?oaeo ?aa?ii?a e?aiai oeoii/ea ? ca’ycie ?o c COA na?ae/eoue i?i ia??aiioe?iiee ieoiiee aianie cii e?aiai oeoii/ea a caaaeueio eiai nei?ioeea?noue i?e noaa?e?caoe?? AO. A?eueo aeeiai?/ieie a i?ioean? i?ia?anoaaiiy caoai?thaaiiy aeyaeeenue na?oeaa? ia’?ie. Oae, EAeI c??n ia 8.3%, ui neeaei aeinoia??io ??cieoeth a ii??aiyii? c aiaeia?/iei iieacieeii i?e ? noaae?? AO. Ua a?eueo ae?aaeaieo ci?i caciaa ENI, i?e??no yeiai aei??aithaaa 31.1%. Naia inoaii? ? coiiaeei nooo?aa cieaeaiiy OI o oeeo oai?eo. O e?euee?niiio ae?aaeaii? ??cieoey i?e ii??aiyii? iaio a?oi neeaaeaea 13% ? aoea aeinoia??iith. ?acoeueoaoe aeine?aeaeaiiy nenoie?/ii? ? ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea na?ae/aoue i?i oa, ui i?e ? no.AO niinoa??aa?oueny i?aeneeaiiy i?ioeano aeaiaiiy, yea i?iyaey?oueny, a iniiaiiio, c?inoaiiyi oaeaee?nieo iieaciee?a ( Vcf ? OAi). *ania? oa?aeoa?enoeee nenoiee oaae aeaui ci?ithaaeenue, aea o?eueee a iaaeao oaiaeaioe?? aei aei?i/aiiy. O oai?eo c ?? no.AO niinoa??aaeinue noaoenoe/ii aeinoia??ia cieaeaiiy an?o oaeaeeinoae aeaiaiiy, ye a ii??aiyii? c eiio?ieai, oae ? a a?eueo?e i???, c oai?eie ? no. Ciiao ae oaee, ia ??ai? oaiaeaioe?? caeeoeeinue iiaeiaaeaiiy /ano aeinyaiaiiy iaeneioio oaeaeeino? aeaiaiiy.Nooo?ai ciaioeeenue ? oae? iieacieee ye NIONA ? V cf, iaeiae, a?eueo no??ieiai cieaeaiiy caciaea oaeaee?noue aei?i/aiiy oee?eoey?ieo aieieii i?iea?aea.Oae? ae?aaeai? ci?ie oa?aeoa?enoee nenoiee i?e i?aeoe/ii iaci?iiiio /an? aeaiaiiy, iiaeooue na?ae/eoe ia eeoa i?i iia??oaiiy nenoie?/ii? ooieoe??, aea e i?i ia?aaoaeiao no?oeoo?e nenoiee. A?aoiaoth/e oie oaeo, ui o oai?eo c ?? no.AO aeyaeany cieaeaiei ? OI, iiaeia c?iaeoe aeniiaie, ui a noeoiiino? an? aeuaa?aei?/ai? oaeoi?e aeacothoue ia iia??oaiiy nei?ioeeai? ooieoe?? i?iea?aea ia noaae??, caaaeii, ua no?eei? ea?ae?aeueii? eiiiainaoe??. Inoaii?i /anii cia/ii i?aeaeueany ?ioa?an aei ae?anoie?/ieo aeanoeainoae e?aiai oeoii/ea na?oey i?e AO . Oai?aoe/ieie ia?aaeoiiaaie aeey oeueiai noaea aeiaaaeai?noue oiai oaeoo, ui niia?eueiaiiy ?aiiueiai e?aioeoii/ei-aiai iaiiaiaiiy ?icaeaa?oueny ?ai?oa a?ae ci?i o?aeoe?? aeeeaeo, oaea?iiai ia’?io ? oaeaeeinoae aeaiaiiy, a oaeiae i?aeoaa?aeaeaiiy iacaeaaeiino? i?ioean?a nei?i/aiiy ? ?icneaaeaiiy uiaei ?o aia?aicaaacia/aiiy. Aeiaaaeaii a?eueoo /ooeea?noue i?iea?ae?aeueiiai ?icneaaeaiiy aei aeao?oeeoo eenith, /a?ac ui ii?ooaiiy ae?anoie?/ii? ooieoe?? ia?aaeothoue ci?iai nei?ioeeaino? . Iaea?aeai? aeai? na?ae/aoue, ui i?e ?? no.AO ae?anoie?/ia ooieoe?y ii?ooaia ye a ii??aiyii? c eiio?ieai, oae ? c ? noaae??th caoai?thaaiiy. Oea i?iyaeeinue cieaeaiiyi iaeneiaeueii? oaeaeeino? iaiiaiaiiy ? iiaeiaaeaiiyi /ano ?? aeinyaiaiiy. Iath/e ia oaac?, ui o oai?eo ?? no.AO iaee i?noea ci?ie no?oeoo?e nenoiee, eiiieaen ia?aiao??a ?IAA aoa aeei?enoaiee aeey aea/aiiy no?oeoo?e ae?anoiee ( oaae.8). Oaaeeoey 8 No?oeoo?a ae?anoiee o oai?eo AO ??cieo noaae?e ____________________________________________________________________ Iieacieee Eiio?ieue : ? no.AO : ?? no. AO n =10 n=30 n=90 ______________ OI 1/3 % 48.3+2.1 56.4+3.0 * 38.2+1.9* OI 2/3 % 60.1+4.0 47.1+2.7 * 63.4+3.9 AeI 1/3 ni 3 89.4+4.1 83.7+3.6 84.4+4.0 AeI 2/3 ni 3 105.6+3.8 77.3+2.8 101.2+3.1 OIi n-1 3.3 +0.8 4.0 +0.6* 2.6+0.6 * O-OIi in 136.1+2.2 150.6+11.2 189.0+10.5 * - aeinoia??i?noue ??cieoe? (? <0.05) ________________________________________________________________________ Aeine?aeaeaiiy caeaaeiino? na?oeaaiai aeeeaeo a?ae ae?anoie?/iiai iaiiaiaiiy ?icaeaaeenue a oe?ieeo iaaeao: aoea iieacaia, ye caeaaei?noue ae?anoie?/iiai iaiiaiaiiy a?ae ??aiy nei?ioeeai? aeoeaiino? na?oey, oae ? aeiaaaeaia iiaeeea?noue i?aeaeuaiiy nei?ioeeaeo aeanoeainoae aac ci?i aeo?aeiiai ae?anoie?/iiai iaiiaiaiiy, a i?ae aieeaii oaeeo oaeoi??a, ye eaoaoieai?ie, o?ce/ia iaaaioaaeaiiy ? i?aeaeuaiiy oeneo a ea?ioeaeiiio neion?. Iao? aeai? aeeaaeathoueny a oae? oyaeaiiy, ine?eueee, naia i?e ? no.AO, aoei iaea?aeaia aeinoia??ia c?inoaiiy o?aeoe?? iaiiaiaiiy ia?oi? o?aoeie ae?anoiee, yea ii?aeioaaeinue c? ca?eueoaiiyi iaeneiaeueii? oaeaeeino? iaiiaiaiiy. Nooo?ai cia/ei? ci?ie oeeo aea iieaciee?a, aea i?ioeeaaeii? iai?aaeaiino?, niinoa??aaeenue i?e ?? no.AO - cieaeoaaeanue OIi ? OI 1/3 ae?anoiee. O?aeoe?? iaiiaiaiiy ae?oai? o?aoeie ae?anoiee ocaiaeaeoaaeenue c? ci?iaie OI 1/3, aea a oie aea /an, na?ae/eee i?i ia?a?iciiae?e iaiiaiaiiy e?aiai oeoii/ea o oai?eo c ? no.OA a iai?yieo a?eueo ?aiiueiai iaiiaiaiiy, a i?e ?? no. - a iai?yieo a?eueo i?ciueiai ae?anoaceno. Aeoiaey/e c oiai, ui o an?o ianoaaeaieo ye c ia?oith, oae ? ae?oaith noaae??th AO, a?aei?/aany eiiiainiaaiee noai aioo??oiueina?oeaai? aaiiaeeiai?ee ? nei?ioeeaino? i?iea?aea, eiiieaen ia?aiao??a ?IAA aoa aeei?enoaiee a ii?aeiaii? c aeiciaaiei o?ce/iei iaaaioaaeaiiyi aeey ioe?iee i?iea?ae?aeueiiai ?aca?ao e?aiai oeoii/ea oa nooiaiy eiai aeinoaoiino?. I?ae aieeaii AeOI o oai?eo c ? no.AO niinoa??aaeenue iaeiiiai?aaeai? ci?ie caaaeueii? ? ?aa?iia?ii? nei?ioeeaino? a iai?yieo i?aeaeuaiiy an?o o?aeoe?e aeeeaeo. Na?oeaa? ia’?ie aeinoia??ii cieaeoaaeenue, oaea?iee ia’?i caeeoeany iaci?iiei. A?aei?/aii i?enei?aiiy oaeaeeinoae nenoie?/iiai aeaiaiiy oa aei?i/aiiy /ano aeinyaiaiiy iaeneiaeueii? oaeaeeino?. Ci?ie ae?anoie?/ii? ooieoe?? i?iyaeeenue i?aeaeuaiiyi iaeneiaeueii? oaeaeeino? iaiiaiaiiy ? oaiaeaioe??th aei aei?i/aiiy /ano ?? aeinyaiaiiy. Oiaoi, iaea?aeai? aeai? na?ae/eee i?i aaeaeaaoia aaiiaeeiai?/ia caaacia/aiiy o?ce/iiai iaaaioaaeaiiy i?e ? no.caoai?thaaiiy . O?ce/iee oano o oai?eo c ?? no.AO ( oaae.9 ) noi?iaiaeaeoaaany i?aeaeuaiiyi COA ia 12.2% (? < 0.05), ca?eueoaiiyi OI ia 12.8% ? Vcf ia 50 %. Oaeaee?ni? iieacieee nei?i/aiiy NIONA ? OAi ca?eueoeeenue ia 36.8% ? 36.2% a?aeiia?aeii. Iieacieee ae?anoie?/iiai iaiiaiaiiy OIi ? O-OIi ia ci?ithaaeenue. Iiae?ai? ?acoeueoaoe aeacothoue ia oa, ui o?ce/iee oano i?e ?? no.AO oa?aeoa?eco?oueny ae?aaeaiith aeoeaaoe??th nei?ioeeai? ooieoe?? i?iea?aea, ui i?iyaeeinue o i?aeaeuaii? oaeaeeinoae aeaiaiiy, ca?eueoaii? caaaeueii? o?aeoe?? aeeeaeo, oaea?iiai ia’?io ? V cf. I?ioa, oea ia ii?aeioaaeinue c? ci?iaie iieaciee?a, ui oa?aeoa?ecothoue oaeaee?noue ?aiiueiai ae?anoie?/iiai iaiiaiaiiy: OI i ? O-OI i i?ae /an iaa?ocee ia ci?ithaaeenue. Ioaea, o ianoaaeaieo oai?eo a oiiaao iaaaioaaeaiiy aeyaeaia iaaeinoaoi?noue ae?anoie?/ii? ooieoe??, yea i?iyaeeanue a?aenooi?noth ?aaeoe?? iieaciee?a iaiiaiaiiy ia oano. I?aenoiiaoth/e, iiaeia noaa?aeaeoaaoe, ui ia aoai? noaa?e?caoe?? a?oa??aeueii? a?ia?oaic?? ca aeaieie ?IAA iaea?eueo ?iaeeeaoeaieie ia?aiao?aie aeyaeeenue iieacieee nenoie?/ii? oa ae?anoie?/ii? ooieoe??, a oaeiae no?oeoo?e oac aeaiaiiy ? iaiiaiaiiy na?oeaaiai nei?i/aiiy. Aaaeeea?noue ?ie? aioo??oiueina?oeaai? aaiiaeeiai?ee a i?iaeai? o?ii?/iiai eaaaiaaiai na?oey iaoiiaeth? iaiao?aei?noue aea/aiiy ae?yeueiino? iaio oeoii/e?a ? ?o aca?iiae?? a oiiaao aoi?eiii? eaaaiaai? a?ia?oaic??. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue noiniaii ii/aoeiai? ENI aeyaeee nooo?aa i?eai?/aiiy nei?ioeeai? ooieoe?? i?iea?aea iaio oeoii/e?a na?oey ca ?aooiie caaaeueii? oa ?aa?iia?ieo o?aeoe?e aeeeaeo, ye? aoee aeinoia??ii ieae/eie, i?ae o in?a eiio?ieueii? a?oie. Caaaeueia o?aeoe?y aeeeaeo neeaea a?aeiia?aeii 48,13+1,48% ? 62,0+6,1% (p < 0,05), ia?aaeiuei-ia?aai?iaeeiaa o?aeoe?y - 41,63+2,43% ? 63,0+10,3% (p< 0.05), aa?o?aeiaa o?aeoe?y -61,5+3,22% ? 70,0+15,2% (p<0.05), caaeiuei-aieiaa - 51,7+3,25% ? 71,0+10,3% (p < 0.05). Ia iaio nooo?aa ??cieoey iieaciee?a ii??aithaaeueieo a?oi aoea a?aei?/aia uiaei ooieoe?iiaeueieo ia’?i?a e?aiai oeoii/ea. Oae, o oai?eo c ii/aoeiaith ENI EAeI aoa 132,23+3,19 ni3, a o in?a eiio?ieueii? a?oie - 121,0+5,3 ni 3 ( p> 0.05), ENI a?aeiia?aeii — 71,03+3,28 ni 3 ?
45,0+ 6,9 ( p < 0.05) , OI - 60,8+2,09 ni 3 ? 77,3+6,4 ni 3 (p < 0.05). Iiae?ai? ci?ie na?ae/aoue i?i aaeaeaaoia i?aeneeaiiy ?iio?iiii? ooieoe?? i?iea?aea, oae ye naia aaee/eia ENI aecia/a? noai ?iio?ii?cio, a oie /an, ye EAeI ? iio?aeiith aaiiciiai iiaa?iaiiy ? ae?anoie?/ieo aeanoeainoae i?iea?aea. Oaaeeoey 9 Iieacieee ooieoe?? e?aiai oeoii/ea o oai?eo c ?? no. AO oa ?o aeeiai?ea i?ae aieeaii AeOI ________________________________________________________________________ __________ A?oia IOA IIOA AOA CAOA EAeI ENI O I V cf NIONA OAi O-OAi OIi O-OIi % % % % ni 3 ni 3 ni 3 n -1 n-1 n -1 in n -1 in ________________________________________________________________________ __________________________________ Oai?? AO I 58.1 55.7 73.4 57.6 108.1 44.1 63.9 0.8 1.9 4.1 161 2.8 165 a niiei? + i 1.52 2.7 1.8 1.4 1.8 1.75 2.1 0.02 0.07 0.3 13.7 0.24 10 Iaa?ocea I 65.2 57.0 79.3 65.5 111.7 45 72.1 1.2 2.6 5.6 163 2.9 143.8 + i 1.0 1.6 2.0 1.9 3.1 1.9 2.3 0.05 0.1 0.47 8.6 0.15 7.9 P <0.05 >0.05 <0.05 <0.01 >0.05 >0.05
<0.01 <0.001 <0.001 <0.02 >0.05 >0.05 >0.05

% 12.2 2.3 8.0 13.7 3.3
2.0 12.8 50 36.8 36.2 1.8 3.5
-14.7

P — aeinoia??i?noue ??cieoe? a niiei? ? i?e
iaaaioaaeaii?

Aiie?ooaeii-/ania? iieacieee ?IAA, ye? oa?aeoa?ecothoue i?ioeane
aeaiaiiy ? iaiiaiaiiy e?aiai oeoii/ea, cana?ae/eee, ui o oai?eo c
ii/aoeiaith ENI a ii??aiyii? c iniaaie eiio?ieueii? a?oie ii?ooaiiy
oi?eioeenue, a iniiaiiio, nenoie?/ii? ooieoe?? i?iea?aea. NIONA aoea
a?aeiia?aeii 1.77+0.1 n-1 ? 2.81+ 0.3 n-1 (P < 0.001), OAi - 3.28+0.3 n-1 ? 5.33+0.27 n-1 (? < 0.001), V cf - 0.82+0.06 c-1 ? 1.56+0.05n-1 ( P < 0.001). Iieacieee ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea i?e ii/aoeia?e ENI oaae ci?ithaaeenue ii a?aeiioaiith aei eiio?ieueiiai ??aiy ? neeaee a?aeiia?aeii OIi - 1.59+0.18 n-1 ? 3.33+0.8 n-1 O-OIi - 211.5+18.6 in ? 136.1+23.0. I?e aiae?c? i?aaeo aaio?eeoeia?ai c’ynoaaeinue, ui o oai?eo c ii/aoeiaith ENI ci?ie nei?ioeeai? ooieoe?? oa aaiiaeeiai?ee i?aaiai oeoii/ea na?oey iaee oaeo ae ni?yiiaai?noue ? ae?aaeai?noue, ye a?aeiia?aei? ci?ie e?aiai oeoii/ea. Iiae?aia aiaeia?/i?noue caa??aaeanue ? i?e ni?anoaaeaii? ia?aiao??a a?oie oai?eo ? eiio?ieueii? a?oie. *eneia? iieacieee caaaeueii? ? ?aa?iia?ii? nei?ioeeaino?, nenoiei-ae?anoie?/ii? ooieoe?? i?aaiai oeoii/ea ? eiai ia’?i?a noaiiaeee : COA - 42.8+ 1.67, IIOA - 37.8+3.0, AOA - 48.5+3.0, CAOA - 48.7+3.16, EAeI - 131.8+ 3.18, ENI - 74.4+2.85, OI - 57.4+2.36, NIONA - 1.74+0.13, OAi - 2.93+0.04, O-OAi -154.5+8.4, OIi -1.66+0.21, O-OIi - 188.2+14.9, V cf - 1.32+0.09, Oaeai.301.1+24.7. Cieaeaiiy nei?ioeeai? ooieoe?? i?iea?aea oa ?iceaaee aioo??oiuei-na?oeaai? aaiiaeeiai?ee o oai?eo ia o?ii?/iee iano?oeoeaiee a?iio?o c ii/aoeiaeie ii?ooaiiyie ooieoe?? aeeoaiiy ? e?iaiia?ao a?aeaoaathoueny iaeii/anii ? a iaeiiio iai?yieo a iaio oeoii/eao na?oey. Ca aeaieie e?oa?aoo?e /A.O. Eenaeueiaa,1985; A.N.Naeioeeoeueeee, 1987, ?.?.?eueieoeueeee ,1994) oeae oaeo iiynith?oueny ?ioaeoe?eii-oiene/ieie ? ?ioaeoe?eii-aea?a?/ieie aieeaaie ia i?iea?ae iaio oeoii/e?a, eio?? aeeeeeathoue eiai aeeno?io?/ia o?aaeaiiy. I?e ia?o?e noaae?? ENI (oaae.10) a?aei?/aeenue a?eueo ae?aaeai? ii?ooaiiy nei?ioeeai? ooieoe?? a ii??aiyii? c ii/aoeiaeie i?iyaaie iaaeinoaoiino?. O oeeo oai?eo ii?oooaaeanue ia o?eueee nenoie?/ia, aea ? ae?anoie?/ia ooieoe?y i?iea?aea. Ii?ooaiiy ae?anoie?/ii? ooieoe?? i?iea?aeo i?iyaeeinue ciaioaiiyi iaeneiaeueii? oaeaeeino? iaiiaiaiiy c 1,66+0,21 n-1 o oai?eo c ii/aoeiaith ENI aei 1,09+0,09 n-1 (? <0.05) o oai?eo c ENI ? no., a oaeiae oaiaeaioe??th aei ca?eueoaiiy /ano aeinyaiaiiy iaeneiaeueii? oaeaeeino? a?aeiia?aeii c 188,28+14,9 in aei 233,2+17,4 in (? >0.05).
I?iyaii ii?ooaiiy nenoie?/ii? ooieoe?? i?iea?aea noaei cieaeaiiy NIONA c
1,74+0,14 n-1 o oai?eo c ii/aoeiaith ENI aei 1,33+0,1 n-1 (? <0.05) o oai?eo c ENI ? no., a oaeiae oaiaeaioe?y aei cieaeaiiy oaeaeeino? aei?i/aiiy e?oaiaeo aieieii i?iea?aeo a?aeiia?aeii c 0,74+0,07 n-1 aei 0,67+0,05 n-1 ( ? > 0.05 ).

Oaaeeoey 10

I?aaee ? e?aee oeoii/ee na?oey o oai?eo c ia?oith noaae??th ENI

ca aeaieie ?IAA

________________________________________________________________________

Ia?aiao?e I?aaee oeoii/ie
E?aee oeoii/ie

COA % 40.8+1.73
45.6+1.62

IIOA % 38.7+2.8
37.5+3.3

AOA % 51.1+3.27
57.0+2.9

CAOA % 54.8+4.3
51.6+3.7

EAeI ni3 145.4+4.4.
145.0+3.9

ENI ni3 83.4+2.8
80.1+2.9

OI ni 3 61.1+3.7
65.0+3.0

NIONA n-1 1.33+0.1
1.8+0.12

V cf c-1 0.67+ 0.07
0.71+0.04

OAi n-1 2.9+0.24
3.3+0.4

O-OAi in 166.2+15.9
182.4+15.9

OIi n-1 1.09+0.09
1.96+0.32

O-OIi in 233.2+17.4
192.2+21.8

O aeai. in 264.8+17.9
299.7+18.4

_______________________________________________________________

Ne?ae a?aei?oeoe, ui ??cieoey a ii??aithaaieo a?oiao oai?eo noiniaii
e?aiai oeoii/ea a?aeiineeanue, a iniiaiiio, aei ooieoe?iiaeueieo ia’?i?a
oa aeayeeo aiie?ooaeii-/aniaeo oa?aeoa?enoee aeii?iaeiaiiy ? iaiiaiaiiy.
Oae, EAeI o oai?eo c ENI ? no. aoa 145,04+3,94 ni 3, a o oai?eo c
ii/aoeiaith ENI — 132,2+3,19 ni 3, (? < 0.05). ENI neeaa a?aeiia?aeii 80,1+2,92 ni3 ? 71,03+3,28 ni3 (? < 0.05). Aa?oee oaaae ? oie oaeo, ui oaea?iee ia’?i iaio oeoii/e?a na?oey o oai?eo c ENI ? no.a ii??aiyii? c oai?eie, ye? iaee iciaee ii/aoeiai? ENI,nooo?ai ia ci?ithaaany, caeeoath/enue ia ??ai? (57-65ni3 ), aaeaeaaoiiio aeey caaeiaieaiiy eaaaiaaiai oa ia?eoa?e/iiai e?iaiia?ao. Ioaea, iaoai?cie eiiiainaoe?? aioo??oiueina?oeaai? aaiiaeeiai?ee o oai?eo c ENI ? no. ?aae?cothoueny oeyoii ca?eueoaiiy EAeI ? ENI iaio oeoii/e?a na?oey iaeii/anii c? ci?iaie aiie?ooaeii-/aniaeo oa?aeoa?enoee i?ioean?a iaiiaiaiiy ? aeaiaiiy.Aeey e?aiai oeoii/ea oe? ci?ie i?iyaeeenue o ca?eueoaii? iaeneiaeueii? oaeaeeino? iaiiaiaiiy ? nei?i/aiiy /ano ?? aeinyaiaiiy. Aeey i?aaiai oeoii/ea a?eueo oa?aeoa?ieie aoee ciaioaiiy na?aaeiuei-ii?iae?ciaaii? oaeaeeino? nenoie?/iiai aeaiaiiy, cieaeaiiy oaeaeeino? nei?i/aiiy e?oaiaeo aieieii i?iea?aeo, ciaioaiiy oaeaeeino? iaiiaiaiiy ? iiaeiaaeaiiy /ano ?? aeinyaiaiiy. Iaioee nooi?iue ii?ooaiue aiie?ooaeii-/aniaeo ia?aiao??a aeii?iaeiaiiy ? iaiiaiaiiy e?aiai oeoii/ea iiaeia iiynieoe oei, ui eiai ae?yeueiino?, ia a?aei?io a?ae i?aaiai oeoii/ea, ia ia?aoeiaeaeaee oae? oaeoi?e, ye eaaaiaaa a?ia?oaic?y ? i?aeaeuaiee eaaaiaaee noaeeiiee ii??. O iaea?eueo aaaeeeo oai?eo ia OIA c ENI ?? no. a?aei?/aeenue cia/i? ii?ooaiiy aioo??oiueina?oeaai? aaiiaeeiai?ee. I?e oeueiio iniaeeao oaaao i?eaa?oaee ?iceaaee ae?yeueiino? e?aiai oeoii/ea na?oey. Aeyaeeinue, ui caaaeueia oa ?aa?iia?i? o?aeoe?? aeeeaeo e?aiai oeoii/ea o oai?eo c ENI ?? no. aoee nooo?ai iaioeie, i?ae o oai?eo c ENI ? no. Oae, COA a?aeiia?aeii neeaea 32,5+1,91 % ? 45,6+1,62 % ( ? <0.001),IIOA - 24,3+2,61% ? 37,5+3,3 % ( ? <0.01), AOA - 46,30+6,71% ? 57,08+2,91% ( ? < 0.05), CAOA - 31,67+5,33 ? 51,6+3,70 % ( ? < 0.01). Oaea?iee ia’?i ciaioeany c 65,0+3,05 ni3 aei 53,0+4,53 ni3 (? < 0.05), niaaeo caciaea oaeaee?noue nei?i/aiiy oee?eoey?ieo aieieii i?iea?aea - 0,71+0,04 n-1 aei 0.53+0.05 n-1 ( ? < 0.01). Iii?/aia oaeiae oaiaeaioe?y aei cieaeaiiy iaeneiaeueii? oaeaeeino? aeii?iaeiaiiy e?aiai oeoii/ea c 3,3+0,44 n-1 aei 3,14+0,54 n-1 ( ? >0.05) ?acii c aeinoia??iei ca?eueoaiiyi /ano ??
aeinyaiaiiy c 130,5+18,1 inae aei 182,4+15,9 inae ( ? <0.05). Oe? aeai? cana?ae/othoue oie oaeo, ui aeaeiiiainaoe?y OEN o oai?eo ia OIA noi?iaiaeaeo?oueny cieaeaiiyi caaaeueii? oa ?aa?iia?ii? nei?ioeeaino? i?iea?aea e?aiai oeoii/ea, a oaeiae cia/iei ii?ooaiiyi eiai nenoie?/ii? ooieoe??. Ooieoe?iiaeueiee noai i?aaiai oeoii/ea o oai?eo c ENI ?? no. a ii??aiyii? c oai?eie, ye? iaee iciaee ENI ? no. nooo?ai ia ci?ithaaany. Ioaea, iiaeia c?iaeoe aeniiaie, ui a ioe?ioe? oa?aeoa?o ia?aa?ao oa i?iaiico caoai?thaaiiy i?e aaaee?e ENI ia? cia/aiiy noai ia o?eueee i?aaiai, aea ? e?aiai oeoii/ea na?oey. I?e/iio, oe? ii?ooaiiy oi?eathoueny ia o?eueee nenoie?/ii?, aea ? ae?anoie?/ii? ooieoe??. C?ea eiiiainaoi?iiai iaoai?cio i?eaiaeeoue aei cieaeaiiy aoaeoeaiino? ?iaioe e?aiai oeoii/ea na?oey, yeee aaea ia caaacia/o? iaoaaie?/i? iio?aae i?aai?cio. sseui i?e aea/aii? nei?ioeeai? ooieoe?? e?aiai oeoii/ea na?oey ia oii? ?oai?/ii? oai?iae na?oey oa a?ia?oii?/ii? oai?iae, ?IAA aeei?enoiaoaaeanue, oi iaeaea ia aea/aeenue nei?ioeea?noue iaio oeoii/e?a i?e ii?ooaiiyo ?eoio na?oey, iaa?aeiiee oa?aeoa? ci?i ?aa?iia?ii? nei?ioeeaino? i?iea?aea, eieae?caoe?? cii c i?aeaeuaiith ooieoe?iiaeueiith aeoeai?noth i?e oae caaiiio “ a?eoi?/iiio” na?oe? o oai?eo c ?OA. A oiae? aiae?co aeyaeaii, ui nei?ioeeaa ooieoe?y e?aiai oeoii/ea ii?ooaia o an?o oai?eo, ye /ooeeaeo aei aioea?eoi?/ieo i?aia?ao?a, oae ? c /?oeeie iciaeaie ?ao?aeoa?iino?. A naia, COA cieaeoaaeanue ia 25 % - i?e ?OA a ii??aiyii? c? caei?iaeie (p < 0.05) ? ia 14 % - c eiio?ieueieie aaee/eiaie oeueiai iieacieea. E?euee?nia ioe?iea ?aa?iia?ii? nei?ioeeaino? aeyaeea ia??aiii??i?noue ieoiiiai aianeo ??cieo cii a caaaeueio i?iaeoeoeai?noue e?aiai oeoii/ea, ui no?oeoo?ii i?iyaeeinue a cieaeaii? OA ia?aaeiuei-ia?aai?iaeeiai? iaeano?. I?e a?aenooiino? iciae na?oeaai? iaaeinoaoiino? o oai?eo c ?OA cao?eniaai? ci?ie ianinii? ooieoe??, aioo??oiueina?oeaai? aaiiaeeiai?ee, no?oeoo?e nei?i/aiiy ? ?icneaaeaiiy e?aiai oeoii/ea. Oae, o oai?eo (57 %) c oao?a?eoi??th, ?ao?aeoa?iith aei aioea?eoi?/ieo i?aia?ao?a, COA aoea ieae/ith 50 %, a oie /an, ye a eiio?ieuei?e a?oi? oae? aeiaaeee neeaee eeoa 31 %. Eieaeuei? aneia?a?? no?iee e?aiai oeoii/ea aeyaeai? o 70 % iaoe??io?a c ?OA, 36 % EA. Ia?aeaeueii ca?eueoeeanue ? e?euee?noue naaiaio?a c? cieaeaiith OA ( aei 3,9 o oai?eo c ?OA ? 2,3 a EA). A oeeo oiiaao aaiiaeeiai?/ia caaacia/aiiy ooieoe?? e?aiai oeoii/ea cae?enithaaeinue ca ?aooiie ia’?iieo ci?i, ye? aoee noaoenoe/ii aeinoia??i? o ?ao?aeoa?ieo oai?eo ? eeoa oaiaeaioe?ei? a eiio?ieuei?e a?oi?. sse aeieac, EAeI ca?eueooaaany ia 17% a ii??aiyii? c? caei?iaeie ( ? < 0.01) i?e noaoenoe/ii iaaeinoia??ii ca?eueoaiiio OI ( aei 64+1,7 ni 2) a eiio?ieueieo oai?eo. Aaee/eie oaeaee?nieo iieaciee?a aeaiaiiy aeacothoue ia iia??oaiiy nei?ioeeaino? e?aiai oeoii/ea. Oae, NIONA ? OAi a oaeiae o?nii ca’ycaiee c iath /aniaee iieaciee nooo?ai ci?ithaaeenue. NIONA, iaioa 2 n -1 , niinoa??aaeanue o 59 % iaoe??io?a, ?ao?aeoa?ieo aei AAI ? o 40 % iaoe??io?a EA. ?iaeeeaoeaiee iieaciee ianinii? ooieoe?? - Vcf ciaioeany a?eueo, i?ae a 2 ?ace a ii??aiyii? c? caei?iaeie ethaeueie ? ia 18 % a ii??aiyii? c eiio?ieueiei ??aiai.Iaio ae?aaeaieo ci?i caciaee iieacieee ae?anoiee. Aecia/eeanue oaiaeaioe?y aei ciaioaiiy oaeaeeino? iaiiaiaiiy ? iiaeiaaeaiiy /ano ?? aeinyaiaiiy a ii??aiyii? c? caei?iaeie ethaeueie, aea oe? aaee/eie ia a?ae??ciyeenue i?ae niaith o aeiaaeeo ii??aiyiiy ?ao?aeoa?ieo oai?eo ? iaoe??io?a eiio?ieueii? a?oie. Aeyaeaii oaeiae niia?eueiaiiy iaiiaiaiiy ia?oi? o?aoeie ae?anoiee ( ? < 0.05). Aeacai? ci?ie a?aeaoaaeenue ia oii? c?inoaiiy EAeI, ui na?ae/eoue i?i i?aeaeuaiiy ae?anoie?/iiai iai?oaeaiiy no?iee e?aiai oeoii/ea, ciaioaiiy aoaeoeaiino? ?iaioe eiai ? ca?eueoaiiy aia?aio?ao. Caaaeueia nei?ioeea?noue i?aaiai oeoii/ea, ye ? e?aiai, oa?aeoa?ecoaaeenue ciaioaiiyi COA. O 66 % ?ao?aeoa?ieo oai?eo aiia aoea ieae/ith 50 % ? eieeaaeanue a?ae 29 aei 69 %, a oie /an, ye a eiio?ie? aiia aoea ieae/ith a?ae aeene?ei?iaoe?eiiai ??aiy o 25 % ianoaaeaieo i?e eieeaaii? a?ae 34 aei 74 %. O oai?eo c ?OA oaeiae aeyaeai? no?oeoo?i? ci?ie nenoiee i?aaiai oeoii/ea, a naia a?iie?iac?y ie?aieo eiai naaiaio?a. An? oa?aeoa?enoeee nenoie?/iiai aeaiaiiy ? ae?anoie?/iiai iaiiaiaiiy aiaeia?/ii ci?ithaaeenue. Oae, yeui NIONA ieae/a 1,8 n -1 aaaaeaee ca iciaeo a?iiaeeiai?? i?aaiai oeoii/ea, oi na?aae ?ao?aeoa?ieo oai?eo oaea ea?oeia niinoa??aa?oueny o 47 iaoe??io?a (71 %), a oie /an, ye a EA aiia aoea ieae/ith o 21 oai?iai ( 60 %). Aecia/eeanue no?oeoo?ia ia?aaoaeiaa ae?anoiee, ui i?iyaeeanue ciaioaiiyi o?aeoe?? i?ciueiai iaiiaiaiiy oeoii/ea ( OI 2/3) ia 23 % ( ?<0,05 ) a ii??aiyii? c ii?iith, c? caa?aaeaiiyi ii?iaeueii? aaee/eie o?aeoe?? iaiiaiaiiy ia?oi? o?aoeie ae?anoiee. Noai ianinii? ooieoe?? i?aaiai oeoii/ea oa?aeoa?ecoaaany ca?eueoaiiyi ooieoe?iiaeueieo ia’?i?a, a naia EAeI ? ENI c? caa?aaeaiiyi ia ii?iaeueiiio ??ai? oaea?iiai ia’?io. Ioaea, o oai?eo c ?OA ooieoe?iiaeueiee noaoon i?aaiai oeoii/ea oaeiae cacia? cia/ieo ci?i, ye? noinothoueny ye i?ioean?a nei?i/aiiy, oae ? ae?anoie?/iiai ?icneaaeaiiy. E??i oiai, aeyaeai? iciaee ii?ooaiiy aaiiaeeiai?/ii? i?iaeoeoeaiino? i?aaeo a?aeae?e?a na?oey ca ?aooiie aeei?enoaiiy a?eueo cao?aoeeaeo iaoai?ci?a caaacia/aiiy caaaeueii? nei?ioeeaino?. Iiaeia aaaaeaoe, ui IO o oai?eo c ?OA i?aeaea?oueny a?eueo ae?aaeaiiei ci?iai, i?ae e?aee. A i?aei?enooiiee ia??iae no?oeoo?ii-ooieoe?iiaeuei? ia?aiao?e oeoii/e?a caeaaeaee a?ae iniiaiiai caoai?thaaiiy. O oai?eo c i?iea?aeeoe/iei ea?ae?ineea?icii a?eueoa cii aneia?a?e o i?aaiio oeoii/eo ( aeaea?aei a?eoiiaaiiino? ), i?ae o oai?eo ?ON, a oie /an, ye aeey e?aiai oeoii/ea a?aei?/aia caeaaei?noue i?ioeeaaeii? iai?aaeaiino?. A?eueoa eiie?aoecoth/e oea iieiaeaiiy, ne?ae a?aei?oeoe, ui i?aaee oeoii/ie o oai?eo c ?OA i?iyaey? iciaee a?iie?iac?? ie?aieo naaiaio?a, a?iiaeeiai??, ii?ooaiue ?aeaenaoe?? ?ai?oa, i?ae aiie aeyaeythoueny a e?aiio. Iia??oaiiy nei?ioeeai? ooieoe?? ie?aieo cii, a ??aii ? ?o aeeaae a COA ciaoiaeeoueny a i?yi?e caeaaeiino? a?ae noaiai? ae?aaeaiino? aeeeyoaoe?? oeoii/ea ? ia ca’ycaia c? ci?iaie a i?ia?aei?e nenoai? na?oey . Oaeei /eiii, o oai?eo c “a?eoi?/iei” na?oeai a?aei?/ai? caaaeuei? caeiiii??iino? i?e aea/aii? nei?ioeeaino? i?iea?aeo: aeieeiaiiy cii a?ia?- ? a?iie?iac?? EO ? IO, ciaioaiiy oaeaee?nieo iieaciee?a aeaiaiiy ? iaiiaiaiiy, c?inoaiiy /aniaeo iieaciee?a. Iaei??th c aieiaieo i?iaeai, ye? noiyoue ia?aae ea?ae?ieiaii ? i?iaeaia i?iaiicoaaiiy ?icaeoeo ci?i a i?iea?ae?. A?ae oni?oiiai ?? ae??oaiiy aaaaoi a /iio caeaaeeoue oaeoeea e?ea?y ? aoaeoeai?noue oa?ai??. No/ani? iaoiaee aeine?aeaeaiiy na?oeaai-noaeeiii? nenoaie aeicaieythoue aeineoue iiaii oa?aeoa?coaaoe noai oai?iai ia aeaiee iiiaio, iaeiae, a ye?e i??? iaea?aeaia ?ioi?iaoe?y iiaea aooe aeei?enoaia a ia?aaeaa/aii? iiaeaeueoiai ?icaeoeo oai?iae ? ?? oneeaaeiaiue - ieoaiiy, ui aeiaaa? iiaeaeueoiai aea/aiiy. Aeey ae??oaiiy caaea/? aeai?o iioeiaeueii? no?oeoo?e iiaeae? a ?inoeooo? e?aa?iaoeee AI Oe?a?ie noai?aiee iaoiae a?oiiaiai iae?eo a?aoiaio?a ( IAIA ). Iaeei c aeai?eoi?a oeueiai iaoiaeo ( eiia?iaoi?iee) aeei?enoaiee i?e ae??oaii? caaaeaiue oe??? ?iaioe. Eiie?aoii, a iaoiio aeiaaeeo, a yeino? e?eoa??th aeai?o iaee?aui? ?aa?an?? aeei?enoaiee iaea?eueo iiioey?iee a aeaiee /an e?eoa??e ia?ao?aniiai iieooaaiiy ( Cross Validation). Inoaii?e iiaoaeiaaiee ne?aeoth/ei /eiii: aeey eiaeii? no?oeoo?e ia?aiao?e ioe?iththoueny ia an?e iiiaeeiiino? aeo?aeieo aeaieo ca aeeeth/aiiyi iaeiiai ?yaeea O?, yeee aeei?enoiao?oueny aeey ioe?iee iioeaee i?iaiico. A yeino? ia?aa??i/ieo aeei?enoiaoaaeenue an? ?yaeee ii /a?c?, a iaea?aeai? iioeaee noioaaeenue. Cia/aiiy e?eoa??th Cross Validation oa?aeoa?eco? i?iaiinoe/i? aeanoeaino? iiaeae?, a oiio iiaea aooe aeei?enoaia aeey aeai?o iioeiaeueii? iiaeae?. Aeey oiai, uia iaoe iiaeeea?noue ioe?ieoe ye?noue noai?aieo iiaeaeae any iiiaeeii?noue aeaieo (W) aoea ?icae?eaia ia iaa/aeueio (A) ? oanoiao (A) i?aeaea??ee. Ia an?o aoaiao iiaoaeiae iiaeae? aeei?enoiaoaaeenue aeai? o?eueee c iaa/aeueii? aea??ee A. Oea aeaei iiaeeea?noue ioe?ieoe ye?noue iiaeaeae ia iacaeaaeieo aeaieo oanoiai? i?aeaea??ee A. Ioe?iea yeino? noai?aieo iiaeaeae i?iaiaeeeanue oaeiae ia iniia? ?ioeo e?eoa???a: ii?iiaaii? noie eaaae?ao?a ia iaa/aeuei?e aea??oe?, ii?iiaaii? caeeoeiai? noie eaaae?ao?a ia oanoia?e aea??oe?. E?eoa??? A ? A iieacothoue iane?euee? iiaeaeueiee i?iaiic e?auee i?ae i?iaiic ca na?aaei?ie cia/aiiyie. I?eiyoi aaaaeaoe i?iaiicoaaiiy oi?ioei, yeui ia oanoia?e aea??oe? < 0.3, caaeia?eueiei - i?e < 0.5 ? iacaaeia?eueiei a aeiaaeeo, eiee > 0.8. Cia/aiiy > 1 ia oanoia?e
aea??oe? iieacothoue, ui oi/i?noue i?iaiico c aeei?enoaiiyi oe???
iiaeae? a??oa, i?ae a oiio aeiaaeeo, eiee aoee ae aeei?enoai? i?inoi
na?aaei? cia/aiiy.

Iniiaith aeey noai?aiiy iiaeaeae noaee ?acoeueoaoe ianoaaeaiiy 320
oai?eo c ii?ooaiiyi i?iea?ae?aeueii? ooieoe?? ia oii? ?oai?/ii? oai?iae
na?oey, a?ia?oii?/ii? oai?iae, o?ii?/iiai eaaaiaaiai na?oey. A i?ioean?
?iaioe i?iaiae?ciaaii 26 ia?aiao??a nei?ioeeai? ooieoe?? i?iea?aea
e?aiai ? i?aaiai oeoii/e?a na?oey. Ii?yaeeia? iiia?e iciae a ia?ae?eo
a?aeiia?aeaee oei, i?ae yeei aiie aaiaeeeenue a iiaeaethth/? nenoaie.
Aeai? i’yoe iaoe??io?a c eiaeii? a?oie noaaaee aacith aeey naiiia?aa??ee
noai?aii? iiaeae?.

sse iieacaee ?acoeueoaoe iiaeaethaaiiy i?iaiico ?icaeoeo
i?iea?ae?aeueii? iaaeinoaoiino? o oai?eo c? noaa?eueiith a?oa??aeueiith
a?ia?oaic??th ( AA ?? no.), iaee?auith aeyaeeanue iiaeaeue, a iniiao
yei? iieeaaeaii iciaee 1,2,3,5,7,9. Oiaoi, iaea?eueoiai cia/aiiy
iaaoaaea ?aa?iia?ia nei?ioeea?noue i?iea?aeo e?aiai oeoii/ea, a naia
ia?aaeiuei-ia?aai?iaeeiai? oa aa?o?aeiai? cii, ye? ? iniiaieie
neeaaeiaeie ?ioaa?aeueii? ooieoe?? a?ia?o?ioiaaiiai i?iea?aea i?e
noaa?e?caoe?? AA. Oi?ioee iiaeaeueiee i?iaiic aoa iaea?aeaiee i?e
aeei?enoaii? iiaeae?, noai?aii? ca ne?aeoth/eie iciaeaie
12,14,15,16,18,19. sse aeieeaa? c aeaii? iiaeae?, iniiaieie ??
aecia/ath/eie neeaaeiaeie ? iieacieee, ui oa?aeoa?ecothoue ae?anoie?/io
ooieoe?th i?iea?aea, a naia OIi ? O-OIi. A?aeiinii iaaeniea cia/ei?noue
na?oeaaeo ia’?i?a ia aeaiiio aoai? ?icaeoeo AO iaea??ia?aei?oa
coiiaeththoueny oei, ui a iaoa aeine?aeaeaiiy ia aeeth/aeenue iaoe??ioe
c ae?aaeaiith aeenooieoe??th e?aiai oeoii/ea ( OA < 40%). A naia o oaeeo oai?eo eiiiainaoe?y ii?ooaiue ne?ioeeaino? na?oey ?aae?co?oueny ca ?aooiie ooieoe?iiaeueieo ia’?i?a. Ni?iaa iiaoaeoaaoe i?iaiinoe/i? iiaeae? c aaaaeaiiyi iieaciee?a a?oa??aeueiiai oeneo ( nenoie?/iiai ? ae?anoie?/iiai) cae?i/eeanue iaaaeaei. Iaea?aeai? iiaeae? aeyaeeenue iacaaeia?eueieie ( ia?aaeuoaaea 1). A oiio, aeey aiae?co a oe?e a?oi? aoee aeei?enoai? aeiaeaoeia? i?aeoiaee. I?aenoiiaoth/e, iiaeia a?aei?oeoe, ui o oai?eo c AA ( noaae?y noaa?e?caoe?? AAe) iaea?eueo aaaeeeaeie e?eoa??yie i?iaiicoth/eo iiaeaeae aeyaeeenue ?aa?iia?i? ooieoe?? aeeeaeo ( ia?aaeiuei-ia?aai?iaeeiaa, aa?o?aeiaa), ia?aiao?e ae?anoie?/ii? ooieoe?? ( iaeneiaeueia oaeaee?noue ae?anoie?/iiai iaiiaiaiiy, /an ?? aeinyaiaiiy ? o?aeoe?y iaiiaiaiiy ia?oi? o?aoeie ae?anoiee), oa aaee/eie a?oa??aeueiiai oeneo. Iaioa i?iaiinoe/ia cia/ei?noue a ieai? ?icaeoeo ii?ooaiue ooieoe?? i?iea?aea ?io?o aeei?enoaieo ia?aiao??a coiiaeth?oueny ye iniaeeainoyie i?aeai?o oai?eo, oae ? /a?aia?noth aeeth/aiiy ie?aieo ea?ae?aeueieo oaeoi??a ia iaaieo aoaiao ?aae?caoe?? eiiiainaoi?ieo iaoai?ci?a. C a?oie ianoaaeaieo c ?ON aoee aeae?eai? 100 iaoe??io?a c aieyie a iaeano? a?oaeii? ee?oei?, noaiiea?ae??th ?-??-??? O.E. Oea aoee oai??, yeei cae?enithaaeinue ai?oi-a?ioeaaa ooiooaaiiy, a ?IAA i?iaiaeeeanue aei ? i?ney o??o?a?/ii? ei?aeoe?? ei?iia?iiai e?iaiieeio. Iaea?eueo ?ioi?iaoeaiith a i?iaiicoaaii? ii?ooaiue i?iea?aea aeyaeeanue iiaeaeue, iiaoaeiaaia ia iniia? ne?aeoth/eo ia?aiao??a 1,2,3,10,12,14,17,19,21. Aeaia iiaeaeue i?e ia?aa??oe? ia oanoia?e aea??oe? ni?aoethaaea o 91% aeiaaee?a. Aeniei?ioi?iaoeaieie a i?iaiicoaaii? ii?ooaiue i?iea?aea aeyaeeenue o?aeoe?? aeeeaeo iniiaieo o?ueio cii e?aiai oeoii/ea, a iaea?eueo?e i??? - ia?aaeiuei-ia?aai?iaeeiai?. Oea, eiia??ii, iiynith?oueny e?iaiiinoa/aiiyi i?iea?aea i?e o?ii?/i?e ?oai?/i?e oai?ia? na?oey, aaoa?iaaii?noth eiai o?aaeaiiy, a oaeiae iayai?noth cii aneia?a??. Aeniea nooi?iue ?ioi?iaoeaii? cia/eiino? (< 0.3) aeyaeaia o a?aeiioaii? iieaciee?a EAeI ? OI. Oea ocaiaeaeo?oueny c aeaieie i?i ii?ooaiiy aeiaaeueii? nei?ioeeai? ooieoe?? i?iea?aea o oai?eo c ?ON, oae ye ii i??? i?ia?anoaaiiy caoai?thaaiiy a?aei?/aii noaoenoe/ii aeinoia??ia ca?eueoaiiy EAeI , ENI ? cieaeaiiy OI . Iiaeeeai oea a?aeia?aaea? iaiaaeaiiy ?aca?aieo iiaeeeainoae i?iea?aea i?e a?aeiinii caa?aaeai?e aaiiaeeiai?/i?e i?iaeoeoeaiino? na?oey a noai? niieith.Noai?iue i?aeaeuaiiy EAeI, ENI ? iaenooo?a?oei ?iaeeeaoi?ii ?ioaineaiino? eiiiainaoi?ieo iaoai?ci?a ia ia?ao?aei?e noaae?? a?ae no?eei? eiiiainaoe?? aei aeniaaeaiiy ?aca?aieo iiaeeeainoae i?iea?aea . Aeineoue aenieeie i?iaiinoe/ieie yeinoyie, ye aeyaeeinue, aieiae?thoue ? ia?aiao?e nenoie?/ii? oace na?oeaaiai nei?i/aiiy ( <0.5). Iiaeaethaaiiy, i?iaaaeaia ia iniia? aeaieo ?IAA i?ney AAO, iieacaei noaa?euei?noue i?iaiinoe/ieo aeanoeainoae iniiaieo ia?aiao??a ?IAA. Iioeiaeueiith caeeoaeanue iiaeaeue, noai?aia ia iniia? oeo aea ia?aiao??a, ye? iaea?aeai? i?e ianoaaeaii? oai?eo aei AAO. Iaaiith iniaeea?noth aeyaeeinue i?aeneeaiiy cia/eiino? ?aa?iia?ieo o?aeoe?e aeeeaeo, iniaeeai, ia?aaeiuei-ia?aai?iaeeiai?, ui iniiaiei /eiii ca’ycaii c iniaeeainoyie o??o?a?/ii? ei?aeoe?? ei?iia?iiai e?iaiieeio oa iie?auaiiyi e?iaiiinoa/aiiy iaaieo cii i?iea?aea e?aiai oeoii/ea. Ia iniia? eiiieaeno ia?aiao??a i?aai? ?IAA, ?? aiae?co i?iaaaeaia iiaeaethaaiiy ii?ooaiue i?iea?aea o oai?eo c eiiiainiaaiei eaaaiaaei na?oeai. Iaea?eueo iioeiaeueiith ( 0.3) aeyaeeanue iiaeaeue, noai?aia ia iniia? ne?aeoth/eo ia?aiao??a 1,10,11,12,13,14,15,16,18. Aeineoue aenieith i?iaiinoe/iith oe?ii?noth aieiae?thoue ia?aiao?e 15 ? 16 ( EAeI ? ENI). I?aaee oeoii/ie ia? aaeee? ooieoe?iiaeuei? ?aca?ae ? ni?iiiaeiee aeo?eiaoe cia/i? iaaaioaaeaiiy oeneii, yeee ia?aaeuo? ??ai? eaaaiaai? a?ia?oaic?? i?e ianiaoeeo?/ieo oai?iaao eaaaiue. Caeeoa?oueny, iaeiae, iac?icoi?ea i?e/eia oaeaeei aeieeath/i? neaaino? i?aaiai oeoii/ea naia i?e caoai?thaaiiyo eaaaiue. Aeiioneathoue, ui ia?oi?yaeio ?ieue a ?icaeoeo cano?eieo yaeu i?e aeaeiiiainaoe?? OEN a?ae?a?athoue ia o?eueee neaa?noue na?oeaaiai i’yco, aea ? oae? oaeoi?e, ye ca?eueoaiiy eaaaiaaiai noaeeiiiai iii?o ? ia’?io oee?eoethth/i? e?ia?. Ioaea, i?aenoiiaoth/e, iiaeia a?aei?oeoe, ui iiaeaethaaiiy, i?iaaaeaia ia iniia? eiiieaeno ia?aiao??a ?IAA aeicaieeei ae??oeoe i?iaeaio ioe?iee ?ioi?iaoeaii-i?iaiinoe/ii? cia/eiino? ie?aieo iieaciee?a iaoiaeo, a oaeiae oe?eeo a?oi ia?aiao??a i?e iniiaieo na?oeaai-noaeeiieo caoai?thaaiiyo. AENIIAEE 1.Noai?aiee ?icoe?aiee eiiieaen ia?aiao??a ?IAA aeey ?ioaa?aeueii? ioe?iee nei?ioeeai? ooieoe?? i?iea?aeo ? iiaiei ? aeinoaoi?i, ine?eueee caaacia/o? iaii?aiiee aiae?c nenoiee ? ae?anoiee na?oeaaiai nei?i/aiiy, a oaeiae neeiaeo, aiie?ooaeieo ? /aniaeo eiai oa?aeoa?enoee. 2. Niin?a e?euee?nii? ioe?iee ae?anoiee ia iniia? ?IAA aeicaiey? aecia/aoe oaeaee?ni? oa ia’?ii? iieacieee iaiiaiaiiy a ??ci? oace ae?anoie?/iiai ?icneaaeaiiy. 3. Aeai?eoi, ?ic?iaeaiee ia iniia? iaoaiaoe/ii? aeeoa?aioe?aoe?? e?eai? “aeoeai?noue-/an” caaacia/o? iaoiaee/iee i?aeo?ae aei aea/aiiy no?oeoo?e ae?anoiee, a naia aecia/aiiy o?aeoe?? iaiiaiaiiy ia?oi? ? ae?oai? o?aoei ae?anoiee ? a?aeiia?aeieo ?i ia’?i?a. 4. Eiiieaen ia?aiao??a ?IAA, aia?oa canoiniaaiee aeey aiae?co aeaieo i?aai? aaio?eeoeia?ao??, a iiaiiio ia’?i? oa?aeoa?eco? ooieoe?iiaeueiee noai i?aaiai oeoii/ea na?oey, a oaeiae aea? oyaeaiiy i?i a?aaio?eeoey?i? ii?ooaiiy i?iea?aea. 5. ?aae?iioee?aeia ioe?iea ai?oi-a?ioeaaiai ooiooaaiiy aeyaeea iniiai? i?iea?ae?aeuei? aeaoa?i?iaioe aoaeoeaiino? o??o?a?/ii? ei?aeoe?? ei?iia?iiai e?iaiieeio a caeaaeiino? a?ae aaaeeino? ?ON ? ii/aoeiaiai noaio aioo??oiueina?oeaai? aaiiaeeiai?ee. 6. ?aae?iioee?aeia nai?ioeea noaa?e?caoe?? a?oa??aeueii? a?ia?oaic?? i?e AO caiaeeoueny aei nenoiei-ae?anoie?/ieo ii?ooaiue oa no?oeoo?ieo ci?i oac na?oeaaiai nei?i/aiiy. 7. Ca aeaieie ?IAA iaoai?cie eiiiainaoe?? aioo??oiuei-na?oeaai? aaiiaeeiai?ee a?aeiia?aeii aei iaoaaie?/ieo iio?aa i?aai?cio o oai?eo c eaaaiaai-na?oeaaith iaaeinoaoi?noth ?aae?cothoueny oeyoii ca?eueoaiiy e?ioeaai-ae?anoie?/iiai ? e?ioeaai-nenoie?/iiai ia’?i?a iaio oeoii/e?a na?oey ii?yae c? ci?iaie aiie?ooaeii-/aniaeo oa?aeoa?enoee a i?ioean? aeaiaiiy ? iaiiaiaiiy. 7. A ioe?ioe? oa?aeoa?o ia?aa?ao oa i?iaiico caoai?thaaiiy o oai?eo c aaaeeith ENI ia? cia/aiiy ooieoe?iiaeueiee noai ia o?eueee i?aaiai,aea ? e?aiai oeoii/ea na?oey. Ii?ooaiiy nenoie?/ii? ooieoe?? e?aiai oeoii/ea caiaeeoueny aei ciaioaiiy oaeaeeinoae aeaiaiiy ? iaae?iiy oaea?iiai ia’?io. 8. A i?aei?enooiiee ia??iae o oai?eo c ?ao?aeoa?ieie oao?a?eoi?yie i?e a?aenooiino? iciae na?oeaai? iaaeinoaoiino? aeyaeai? a?iie?iac?y ? aeene?iac?y oeoii/eiaeo naaiaio?a, cieaeaiiy ianinii? ? nei?ioeeai? ooieoe??, ii?ooaiiy no?oeoo?e ae?anoiee iaio oeoii/e?a, a a?eueo?e i??? i?aaiai, ui coiiaeth?ouen ci?iaie, oa?aeoa?ieie aeey oiiiaiai caoai?thaaiiy. 9. Noai?aiiy iaoaiaoe/ieo iiaeaeae ioe?iee noaio i?iea?aeo i?aaiai ? e?aiai oeoii/ea ia iniia? ?IAA caaacia/eei aeei?enoaiiy ?? ia?aiao??a a yeino? aeaiaio?a i?iaiicoth/eo nenoai i?e ??cieo na?oeaai-noaeeiieo caoai?thaaiiyo. 10. O oai?eo c? noaa?eueiith a?oa??aeueiith a?ia?oaic??th iaea?eueo aaaeeeaeie e?eoa?yie i?iaiicoth/eo iiaeaeae aeyaeeenue ?aa?iia?i? o?aeoe?? aeeeaeo e?aiai oeoii/ea, eiai ae?anoie?/i? iieacieee oa aaee/eie a?oa??aeueiiai oeneo. A?aeiia?aeii aei iioeiaeueii? i?iaiinoe/ii? iiaeae?, iaea?eueo cia/eieie ia?aiao?aie o aeyaeaii? ii?ooaiue i?iea?ae?aeueii? ooieoe?? i?e ?ON ? iieacieee ?aa?iia?ii? nei?ioeeaino? e?aiai oeoii/ea, na?oeaa? ia’?ie oa oa?aeoa?enoeee nenoie?/iiai aeaiaiiy. O oai?eo c eiiiainiaaiei eaaaiaaei na?oeai aenieith i?iaiinoe/iith oe?ii?noth aieiae?thoue ooieoe?iiaeuei? ia’?ie iaio oeoii/e?a na?oey ? aiie?ooaeii-/ania? iieacieee aeaiaiiy. Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe?? 1.Ii?aaeaeaiea na?aea/iuo iauaiia o aieueiuo n ?no.aeia?oiie/a- neie aieacie ii aeaiiui ?aaeeiioeeeaeiie aaio?eeoeia?aoee // E?iaiia?auaiea .- 1989 .- ? 2 .- N.6-8 ( ni?aaao. A.O.Oeeaaieia) 2.Radionuklidventriculographie in der Beurteiling der Kontraktions-undPumpenfunktion des Myokards bei Hypertonie im Stadium I// Med.nucl.J.,1989.-N 2 .-P.175-179 (Cygankov A, Zanozdra N.) 3. Ooieoeey ieiea?aea eaaiai aeaeoaei/ea o aieueiuo aeia?oiie/aneie aieaciueth//Iaae.?aaeeieiaey .- 1990.-?1 .-N.29-31( niaao.Oeuaaieia A.O.) 4. ?aaeeiioeeeaeiay aaio?eeoeia?aoey a ioeaiea nie?aoeoaeueiie ooieoeee eaaiai aeaeoaei/ea o aieueiuo aeia?oiie/aneie aieaciueth 1 no. // A?a/aaiia aeaei .-1990 .-? 9 .- N.28-30 (ni?aaao.Oeeaaieia A.O.,Caiicae?a I.N.). 5. Aeeyiea aioaaiienoia eaeueoeey ia no?oeoo?o aioo?ena?aea/iie aaiiaeeiaieee e ooieoeeiiaeueiia ninoiyiea ieiea?aea o aieueiuo ni noaiiea?aeeae, aiciaiiaeaoaeny iinea iia?aoeee AEO// Ea?aeeieiaey.- 1991 .- ?4 .- N.26-30 ( niaao.Eiuoia A.A.,Auoiaaithe E.A.,Oo?eaei N.I.). 6. Eco/aiea nie?aoeoaeueiie ooieoeee eaaiai aeaeoaei/ea o aieueiuo aeia?oiie/aneie aieaciueth 1 no.n iiiiuueth ?aaeeiioeeeaeiie aaio?eeoeia?aoee // Eeei. ?aioaaii-?aaeeieiaey.- 1991 .- aui.21.- N.105-110 ( niaao. Oeuaaieia A.O.). 7. Aeeaaiinoe/aneea aiciiaeiinoe ie?oioaoa i?e na?aea/ii-ninoaeenouo caaieaaaieyo// E?ea?nueea ni?aaa.- 1992.- ? 2.-N.23-25 (niaao.Oeeaaieia A.O.). 8. Ooieoe?y e?aiai oeoii/ea na?oey o oai?eo ia o?ii?/iee iano?oeoeaiee a?iio?o // E?ea?nueea ni?aaa.- 1992.- ? 4.- N.68-70 (ni?aaao. Naoa?/oe ?.?.,Oeeaaieia A.O., ?eueieoeueeee ?.?.). 9. I?aaee oeoii/ie ? oao?a?eoi??. No?oeoo?ii-ooieoe?iiaeueia oa?aeoa?enoeea c aeiiiiiaith ?aae?iioee?aeii? aaio?eeoeia?ao?? //E?ea?nueea ni?aaa.-1992.- ?4 .- N.22-25 ( ni?aaao.Aia?ia A.I.,Oeeaaieia A.O., Eoiiiaeoeueea ?.A.). 10. ?aaeeiioeeeaeiua iaoiaeu enneaaeiaaiey oeaio?aeueiie e ?aaeiia?iie aaiiaeeiaieee o aieueiuo aeeeyoaoeeiiiie ea?aeeiieiiaoeae // E?ea?nueea ni?aaa .- 1992 .-? 5.- N.37-39 ( ni?aaao.Oeeaaieia A.O.) 11. ?aae?iioee?aeia aaio?eeoeia?ao?y ye iaoiae ioe?iee ooieoe?iiaeueiiai noaio oeoii/e?a na?oey o oai?eo c iaaeoeoii/eiaith oao?ea?ae??th // E?ea?nueea ni?aaa .-1992.-? 6.-N.64-66 ( ni?aaao.Oeeaaieia A.O.,Eoiiiaeoeueea ?.A.) 12. Ooieoeeiiaeueiia ninoiyiea na?aeoea i?e aeaeoaei/eiaie oaoeea?aeee ii aeaiiui ?aaeeiioeeeaeiie aaio?eeoeia?aoee// Ea?aeeieiaey.-1992.-? 5.-N.65-67 ( niaao. Aia?ia A.A., Oeuaaieia A.O.,Eoiiiaeoeeay E.A.) 13.Radionuclide ventriculography of arrhythmogenic heart // Neinv. kardiologia.-1992.-N1 P.5-7 (Cygankov A.,Bobrov V,Kupnovitskaya I.) 14. ?aae?iioee?aeia aaio?eeoeia?ao?y oa ?ao?aeoa?i? oao?a?eoi??// Iaoa?.iaoeiai-i?aeoe/ii? eiio. “I?iiaiaaa ae?aaiinoeea caoai?thaaiue a?oaeii? ee?oee” . -Ee?a, 1992 .- N.6-8 (ni?aaao. Eoiiiaeoeueea ?.A.) 15. No?oeoo?a e ooieoeey ieiea?aea o aieueiuo n ?ao?aeoa?iuie oaoea?eoieyie //”Aeia?o.aieaciue,aoa?ineea?ic e ei?iia?.iaaeino.-1993.- aui. 25.- N.28-31 (niaao. Aia?ia A.A.,Eoiiiaeoeeay E.A., Neii?io A.I.) 16. ?aae?iioee?aeia aaio?eeoeia?ao?y a ioe?ioe? ooieoe?iiaeueiiai noaio i?iea?aea o oai?eo c ia?ieneciaie ieaioeeai? a?eoi?? // Oe?.?aae?ieia?/iee aeo?iae.-1993.- ?1 .-N.32-35 (ni?aaao. Oeeaaieia A.O.,Eoiiiaeoeueea ?.A.) 17.Aaiiaeeiai?/ia no?oeoo?a aioeaia?iaeueiiai aoaeoo aioaaii?no?a eaeueoe?th o oai?eo ia ?oai?/io oai?iao na?oey i?ney ai?oi-a?ioeaaiai ooiooaaiiy// Oe?.ea?ae?ieia.aeo?iae,1994 .-? 2.-N.36-39 (ni?aaao.Oo?eaei I.E., Aeoiaaithe ?.A., Eooeue A.I.) 18.Aeeiaieea nenoiee/aneie e aeeanoiee/aneie ooieoeee ieiea?aea i?e oece/aneie iaa?ocea o aieueiuo aeia?oiie/aneie aieaciueth ii aeaiiui ?aaeeiioeeeaeiie aaio?eeoeia?aoee// Oe?.ea?aeeieia.aeo?iae,1995.-? 1.-N.54-57 ( niaao. Naeuaiei A.I.,Eoi/eineay A.A., Eaae?oai A.) 19.Ii??aiyeueia ioe?iea iiaeeeainoae ?aae?iioee?aeii? aaio?eeoeia?ao?? ? aoiea?ae?ia?ao?? o ae?aaiinoeoe? ooieoe?iiaeueiiai noaio e?aiai oeoii/ea o oai?eo c o?aaeaiiyi i?iea?aea // Oe?.?aae?ieia?/iee.aeo?iae.-1996.-? 4.-N.353-358 ( ni?aaao. Eaiaiaoeueeee I.N.,Ia/ia Ae.N., Ia?aae I.A.) 20. ?aaeeiioeeeaeiay aaio?eeoeia?aoey a ioeaiea aeeanoiee/aneie ooieoeee ieiea?aea i?e aeia?oiie/aneie aieacie // Ca??iee iaoeiaeo i?aoeue A?enueeiai-iaaee/ii? aeaaeai?? Oe?a?ie.- Ee?a, 1996 .- N.122-124 ( niaao. Oeuaaieia A.O.I?eiae A.O.,Oeuaaieiaa I.A.) 21. Aiciiaeiinoe eo/aauo iaoiaeia enneaaeiaaiey a aeeaaiinoeea aeieeeie/aneie noaaeee eaaiaeaeoaei/eiaie iaaeinoaoi/iinoe o aieueiuo eoaie/aneie aieaciueth na?aeoea // A?oea eeeie/.e yenia?.iaaeeoeeiu.-1997 .-? 1.-N.13-15 (niaao. Eaiaiaoeeee I.N., Ia/ia Ae.N.,Oeuaaieia A.O.,Ia?aae I.A.) 22.?aae?iioee?aeia aaio?eeoeia?ao?y ye iaoiae ioe?iee ooieoe?iiaeueiiai noaio i?iea?aeo i?e a?ia?oii?/i?e oai?ia? // Oe?.?aae?ieia?/iee aeo?iae.- 1997.-? 5.-N.266-269 ( ni?aaao. Ia/ia Ae.N., Oeeaaieia A.O.) 23. Aioo??oiueina?oeaaa aaiiaeeiai?ea o oai?eo c o?ii?/iei eaaaiaaei na?oeai ca aeaieie ?aae?iioee?aeii? aaio?eeoeia?ao?? // Oe?.?aae?ieia.aeo?iae.-1998.- ?6.- N.284-286 24. ?aaeeiioeeeaeiay ioeaiea yooaeoeaiinoe aioeaiaeiaeueiie oa?aiee o aieueiuo n eoaie/aneie aieaciueth na?aeoea iinea ai?oi-ei?iia?iiai ooioe?iaaiey // Ca??iee iaoeiaeo ?ia?o anioe?aoe?? ?aae?ieia?a Oe?a?ie “I?iiaiaaa ae?aaiinoeea,i?iiaiaaa oa?ai?y”.-1998. 25. ?aaeeiioeeeaeiay aaio?eeoeia?aoey eae niinia enneaaeiaaiey no?oeoo?u aeeanoieu o aieueiuo na?aea/ii-ninoaeenouie caaieaaaieyie // Ca??iee iaoeiaeo ?ia?o A?enueeiai-iaaee/ii? aeaaeai?? Oe?a?ie.- Ee?a, 1999 .-N. 68-72 26. Cia/aiiy iieaciee?a ?aae?iioee?aeii? aaio?eeoeia?ao??, ye ia?aiao??a iiaeaeae i?iaiicoaaiiy ii?ooaiue ooieoe?? i?iea?aea //Ca??iee iaoeiaeo ?ia?o Anioe?aoe?? ?aae?ieia?a Oe?a?ie “I?iiaiaaa ae?aaiinoeea,i?iiaiaaa oa?ai?y” ,i.Ee?a.-1999.- (i?eeiyoi aei ae?oeo) 27. 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