I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo aea?iaoieia?? oa aaia?ieia??

EAA?EIAIEI Ieueaa Ieaen??aia

OAeE 616.5 – 053.3 – 08 : 612.017.1 : 577.1

EIIIEAENIA EI?EAOTH*A OA?AI?ss OAI?EO IA AOII?*IEE

AeA?IAOEO IAIIAEssO ? Ae?OAE ?AIIUeIAI A?EO C O?AOOAAIIssI

CI?I ?IOIIIAI NOAOONO OA NENOAIE E?IIIA?IENEAeAOe??

(14.01.20 – oe??i? oa aaia?e/i? oai?iae)

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

Iaoeiaee ea??aiee aeieoi? iaaee/ieo iaoe, i?ioani?

?iiaiaiei Anaaieiae Ieeieaeiae/

Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao

caa?aeoaa/ eaoaae?e oe??ieo oa aaia?e/ieo oai?ia

Io?oe?ei? iiiiaioe : aeieoi? iaaee/ieo iaoe, i?ioani?

Ai/a?ia Aaneeue Aiae??eiae/

Noinueeee aea?aeaaiee oi?aa?neoao

caa?aeoaa/ eaoaae?e oa?ai?? c eo?nii aea?iaoiaaia?ieia??

eaiaeeaeao iaaee/ieo iaoe, aeioeaio

Aea?aa’yiei Ethaeieea Aiae???aia

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?

ina?oe ?i. I.E. Ooieea

aeioeaio eaoaae?e oe??ieo oa aaia?e/ieo oai?ia

I?ia?aeia onoaiiaa Iaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. aeaae. I.I. Aiaiiieueoey IIC Oe?a?ie,

eaoaae?a oe??ieo oa aaia?e/ieo oai?ia

c eo?nii i?iaeai NI?Ae, i. Ee?a

Caoeno a?aeaoaeaoueny 27 aeiaoiy 1999 ?. i 12 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.64.603.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? aea?iaoieia?? oa aaia?ieia?? ca
aae?anith: 310057, i. Oa?e?a, aoe. *a?ieoaanueeiai, 7/9.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aea?iaoieia?? oa aaia?ieia?? ca
aae?anith: 310057, i. Oa?e?a, aoe. *a?ieoaanueeiai, 7/9.

Aaoi?aoa?ao ?ic?neaii 23 aa?aniy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe, aeioeaio
E.N. Oaoeueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca inoaii? aeanyoe??//y nooo?ai iioe?eeeny oyaeaiiy
i?i aoii?/i? caoai?thaaiiy, na?aae yeeo cia/ia i?noea iin?aea? aoii?/iee
aea?iaoeo (AAe) [Noai?iaa E.I. oa ni?aaao., 1989; Ne?eieei TH.E. oa
ni?aaao., 1995; Eaethaeia E.Ae. oa ni?aaao., 1997; Leung D.Y., 1993;
Cookson W., 1994]. Ieeueia oaaaa aei AAe iia’ycaia c oe?ieith eiai
?iciianthaeaeai?noth, c?inoaiiyi caoai?thaaiino?, a oaeiae iiaeie
i?aeoiaeaie aei aea/aiiy ?ioiieo, iae?iaiaeie?eiieo, iai?iieo oa ?ioeo
eaiie iaoiaaiaco [Ia?aneaaeia E.A. oa ni?aaao., 1996; Ai/a?ia A.A.,
1997; Noai?iaa E.I., 1998; Oiaeueeiaa A.N., Aieioiay E.A., 1999;
Bogunievicz M., 1997; Leung D.Y., 1997]. Aeieeath/e a ia?o? i?nyoe?
aeeooy, AAe c ?ieaie /anoi iaaoaa? o?ii?/iiai ia?aa?ao c o?eaaeeie
?aoeeaeeaaie, ?acenoaioi?noth aei oa?ai??, oiio iiaeaeueoa eiai aea/aiiy
c iaoith i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy ? aaaeeeaei
iaaeeei-nioe?aeueiei caaaeaiiyi [Eieyaeaiei A.A. oa ni?aaao., 1990;
?aae?iiia A.A., 1996; Oi?iiiaa I.I. oa ni?aaao., 1997; Aiiaa?a I.A. oa
ni?aaao.; 1998; Ei/a?aei I.A., 1998]. Ca no/anieie oyaeaiiyie, AAe ?
aaaaoioaeoi?iei caoai?thaaiiyi, ui iaoiiaeth? oe?ie? aniaeoe
aeine?aeaeaiue eiai iaoiaaiaco. Iieacaia ?ieue ii?ooaiue ineoiaiioe?eii?
noa?e, ia?aiai? e aiaeie?eiii? nenoai, aaiiaeeiai?ee [Eanee I.A., 1988;
?oiyioeaaa A.A. oa ni?aaao., 1990; Ai/a?ia A.A., 1994; Eaaiiaa E.I.,
1994; Trask D.M. et al., 1988; Ebata T. et al., 1996; Buske Kirschbaum
A. et al., 1998]. Iaaia cia/aiiy a?aeaiaeeoueny iaoieia?? i?aai?a
o?aaeaiiy [Oi?iiiaa I.I., Neiyaneay I.A., 1993; ?ieanoaaa E.A., 1996;
Ieeaaneay N.A. oa ni?aaao., 1997; Caffarelli C. et al., 1998]. Iaeiae
i?ia?aeiith eaieith a ?icaeoeo AAe aaaaeathoue ii?ooaiiy ?ioiiiai
noaoono e aea?a?/ii? ?aaeoeaiino? [Aeooaiueeee A.O., A?aiaei N.A., 1990;
Noai?iaa E.I., 1998; Maurer D., Stingl G., 1993; Eigenmann P.A. et al.,
1998]. Aeyaeai? ??ciiiai?oi? ci?ie ye ee?oeiii?, oae ? aoii?aeueii?
eaiee ?ioi?oaoo, a oaeiae ianiaoeeo?/ii? ?acenoaioiino? i?e AAe
[Ai?eaiia E.A. oa ni?aaao., 1987; Eaethaeiay E.Ae., 1989; Ciaiaineay
E.O., 1994; ?iaeeiiia A.I. oa ni?aaao., 1996; Chiarelli F. et al., 1987;
Amon E.U., 1991; Lonati A. et al., 1999]. Aeiaaaeaia nainea?e?caoe?y
i?aai?cio oai?eo aei aaaaoueio aea?aai?a: oa?/iaeo, iiaooiaeo, ieeeiaeo,
aaeoa??aeueieo, aea a?aeiiino? i?i ?? iniaeeaino? a ??ci? a?eia?
ia??iaee iaiaeiicia/i? [Io?iooaiaaoia AE.I., 1984; Nainiiia A.A., 1984;
Germano P. et al., 1993; Lindgren L. et al., 1995; Hanifin J.M., 1997;
Varela P. et al., 1999]. ?ica?aei?noue, a ?ieiee e ae?aiao?aeueia
i?ioeeaaei?noue io?eiaieo aeaieo aeeeeeathoue iaiao?aei?noue
iiaeaeueoiai aea/aiiy caeiiii??iinoae ci?ie ia?aiao??a ?ioiiaiiainoaco
oai?eo ia AAe, iniaeeai a a?oaeiiio oa ?aiiueiio aeeoy/iio a?oe? –
ia??iae? aeaathoo aea?iaoico.

A inoaii? ?iee i?e ??cieo iaoieia?/ieo i?ioeanao ?ioaineaii aea/a?oueny
no?oeoo?ii-ooieoe?iiaeueiee noai ee?oeiieo iaia?ai, ci?ie yeiai
iia’ycothoue c ?ioaineai?noth ia?aeeniiai ieeneaiiy e?i?ae?a (IIE).
Aeyaeaii aca?iica’ycie ii?ooaiue iaoaaie?cio e?i?ae?a iaia?ai c
ae?aaeai?noth IgE-a?aeiia?ae? i?e aoii?/ieo oai?iaao o ae?oae
[Aaeaaieeei E.E., 1998]. ?acoeueoaoe aeine?aeaeaiue na?ae/aoue i?i
cia/i? ci?ie i?ioean?a IIE o oai?eo ia AAe [Noieaiaa N.A. oa ?i., 1987;
Caoa?ia I. A., 1987; Aieiooei A. A., 1992; Ia?aneaaeia E.A. oa ni?aaao.,
1996, Oaaae I.I. oa ni?aaao., 1998]. I?ioa a?aenooi?noue eiiieaenii?
ioe?iee noaio a?eueii?aaeeeaeueii? e aioeieenethaaeueii? nenoai,
noia?a/eea?noue iayaieo aeaieo ?iaeyoue aeioe?eueiei iiaeaeueoa aea/aiiy
noaio e?iiia?ieneaeaoe?? i?e AAe.

Iacaaaeath/e ia ?nioth/ee o ?icii?yaeaeaii? e?ea??a aaeeeee a?naiae
??ciiiai?oieo iaaeeeaiaioicieo ? iaiaaeeeaiaioicieo oa?aiaaoe/ieo
cania?a, i?iaeaia e?eoaaiiy AAe caeeoa?oueny aeooaeueiith. Aaaaoi c
cai?iiiiiaaieo iaoiaeee iathoue iaiaaeaiiy aei canoinoaaiiy o a?oaeiiio
oa ?aiiueiio aeeoy/iio a?oe? [I?ioeaiei O.A., 1998]. *ano? aea?a?/i?
?aaeoe?? ia iaaeeeaiaioe i?e AAe niiioeathoue aei aeei?enoaiiy e?e?a
?ineeiiiai iioiaeaeaiiy, ui, ye i?aaeei, ? iaio oe?aeeeaeie aeey
i?aai?cio. No/ani? e?eoaaeuei? i?aeoiaee a iaaeinoaoi?e i???
a?aoiaothoue iiaeeea?noue ei?aeoe?? no?oeoo?ii-ooieoe?iiaeueiiai noaio
ee?oeiieo iaia?ai i?e AAe.

C o?aooaaiiyi aeuacacia/aiiai aeooaeueiith ? i?aeoe/ii cia/ouith ?
?ic?iaea iiaeo iaoiaaiaoe/ii iaa?oioiaaieo iaoiae?a e?eoaaiiy oai?eo ia
AAe iaiiaeyo ? ae?oae ?aiiueiai a?eo, ni?yiiaaieo ia ei?aeoe?th
ii?ooaiue ?ioiiiai noaoono oa noaio IIE.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?aeaeaiiy ?
o?aaiaioii eiiieaenii? iaoeiai-aeine?aeieoeueei? ?iaioe eaoaae?e oe??ieo
oa aaia?e/ieo oai?ia Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
«?ic?iaea iiaeo iaoiae?a e?eoaaiiy oa i?io?eaeoeee oyaeeeo o?ii?/ieo
aea?iaoic?a ? neo?e?no» (oeo? EE 95.02.06, ? aea?ae?a?no?aoe??
0195V009649).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa aeine?aeaeaiiy – aea/eoe
?ioii-aea?aieia?/iee noaoon, aaeain a?eueii?aaeeeaeueii? e
aioeieneaeaioii? nenoai o oai?eo ia AAe iaiiaeyo ? ae?oae ?aiiueiai a?eo
oa ?ic?iaeoe iiaee eiiieaeniee iaoiae e?eoaaiiy c o?aooaaiiyi aeyaeaieo
ii?ooaiue.

Aeey aeinyaiaiiy noi?ioeueiaaii? iaoe aoei iinoaaeaii oae? caaea/?:

I?iaanoe eiiieaenio ioe?ieo ?ioiiiai noaoono, aeeth/ath/e ee?oeiio oa
aoii?aeueio eaiee, iieacieee ianiaoeeo?/ii? ?acenoaioiino?, e aea?a?/ii?
?aaeoeaiino? o oai?eo ia AAe iaiiaeyo ? ae?oae ?aiiueiai a?eo.

Aea/eoe noai ia?aeeniiai ieeneaiiy e?i?ae?a ? aioeieneaeaioiiai caoenoo
o iaiiaeyo ? ae?oae ?aiiueiai a?eo, ui no?aaeaeathoue ia AAe, c iiceoe??
aaeaino nenoaia-aioenenoaia, ?o ei?aeyoe?ei? aca?iica’ycee c ee?i?/ieie
iniaeeainoyie oa iieacieeaie ?ioiii? nenoaie.

Ia i?aenoaa? aeaieo ?ioii-aea?aieia?/iiai ianoaaeaiiy ? iieaciee?a
nenoaie e?iiia?ieneaeaoe?? ?ic?iaeoe iaoiae eiiieaeniiai e?eoaaiiy
oai?eo ia AAe c aeei?enoaiiyi ?ioiiiiaeoeyoi?a aaeieaio oa
iaia?aiinoaa?e?caoi?a eaoioeoaio.

Aea/eoe oa?aiaaoe/io aoaeoeai?noue ?ic?iaeaiiai e?eoaaeueiiai eiiieaeno,
ui aeeth/a? aaeieai, eaoioeoai, ii?aeiaiiy oeeo i?aia?ao?a, a oaeiae
ioe?ieoe aeeiai?eo ia?aee?i?/ieo iieaciee?a o i?ioean? e?eoaaiiy
cai?iiiiiaaiei iaoiaeii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa o iaiiaeyo ? ae?oae
?aiiueiai a?eo c AAe eiiieaenii aea/aii ?ioiiee noaoon, aeeth/ath/e
ee?oeiio oa aoii?aeueio eaiee, iieacieee ianiaoeeo?/ii? ?acenoaioiino? e
aea?a?/ii? ?aaeoeaiino?; anoaiiaeaii aca?iica’ycie aeyaeaieo ii?ooaiue
c? nooiaiai oyaeeino? oa aeaai?noth aea?iaoico, ee?i?/iith aoaeoeai?noth
oa?ai??. Ooi/iai? iniaeeaino? nainea?e?caoe?? i?e AAe a a?oaeiiio oa
?aiiueiio aeeoy/iio a?oe?.

Aia?oa c iiceoe?? aaeaino nenoaia-aioenenoaia ioe?iaii noai i?ioean?a
e?iiia?ieneaeaoe?? oa aioeieneaeaioiiai caoenoo, anoaiiaeaii
iaoiaaiaoe/ia cia/aiiy oeeo ci?i i?e AAe. ?ic?iaeaii ?ioi?iaoeaiee
iieaciee ni?aa?aeiioaiiy a?eueii?aaeeeaeueii? e aioeieenethaaeueii?
nenoai – ?iaeaen niieo/aiino? ieenethaaeueieo nenoai, ui oa?aeoa?eco?
nooi?iue ae?aaeaiino? ii?ooaiue i?ioean?a IIE. Ooi/iaii aeaye? iaoai?cie
?icaeoeo AAe ia iniia? anoaiiaeaieo ei?aeyoe?eieo aca?iica’yce?a eiai
ee?i?/ieo iniaeeainoae, noaio ?ioiii? nenoaie ? i?ioean?a
e?iiia?ieneaeaoe??.

I?iaaaeaii eiiieaenio ee?i?/io, ?ioiieia?/io, a?io?i?/io ioe?ieo
aoaeoeaiino? cai?iiiiiaaii? iaoiaeeee niieo/aiiai aeei?enoaiiy
?ioiiiiaeoeyoi?a aaeieaio oa iaia?aiinoaa?e?caoi?a eaoioeoaio.
Iaa?oioiaaii aeioe?euei?noue canoinoaaiiy cacia/aiiai iaoiaeo e?eoaaiiy
aeey ii?iae?caoe?? ci?iaieo ia?aiao??a ?ioiiiai noaoono ? aaeaino
a?eueii?aaeeeaeueii? e aioeieenethaaeueii? nenoai.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii iniiai?
caeiiii??iino? ci?ie ?ioiiiai noaoono oa nenoaie e?iiia?ieneaeaoe?? o
oai?eo ia AAe iaiiaeyo ? ae?oae ?aiiueiai a?eo, aeyaeaii iaea?eueo
?ioi?iaoeai? iieacieee, ui oa?aeoa?ecothoue oyaee?noue ? o?eaae?noue
oe??iiai i?ioeano.

Cai?iiiiiaaii ?iaeaen niieo/aiino? ieenethaaeueieo nenoai, ui
oa?aeoa?eco? ae?aaeai?noue aeenaaeaino a nenoai? IIE – aioeieneaeaioiee
caoeno, aeey ioe?iee aoaeoeaiino? e?eoaaiiy.

?ic?iaeaii e ai?iaiaaii iaoiae eiiieaeniiai e?eoaaiiy AAe o iaiiaeyo ?
ae?oae ?aiiueiai a?eo c aeei?enoaiiyi ?ioiiiiaeoeyoi?a aaeieaio oa
iaia?aiinoaa?e?caoi?a eaoioeoaio. I?iaeaiiino?iaaii ae?aaeaio ee?i?/io
aoaeoeai?noue ii?aeiaiiai canoinoaaiiy aaeieaio oa eaoioeoaio,
noaa?euei?noue aeinyaiooiai e?eoaaeueiiai aoaeoo ? a?aenooi?noue
iia?/ieo yaeu.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii naiino?eii neeaaeaii oa
aeeiiaii i?ia?aio aeine?aeaeaiiy, i?iaaaeaii aiae?c aeaieo e?oa?aoo?e,
c?iaeaii on? iaiao?aei? aeniiaee. Aaoi?ii iniaenoi i?iaaaeaii
ee?i?ei-eaai?aoi?ia ianoaaeaiiy 167 oai?eo ia aoii?/iee aea?iaoeo.
Cia/io e?euee?noue eaai?aoi?ieo aeine?aeaeaiue aeeiiaii aaoi?ii
naiino?eii aai ca eiai aaciina?aaeiuei? o/ano?. E?euee?nia, noaoenoe/ia
ia?iaea oa iaoeiaa ?ioa?i?aoaoe?y io?eiaieo aeaieo cae?eniaia oaeiae
aeeeth/ii aaoi?ii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeaii
oa iaaiai?aii ia:

iaoeiai-i?aeoe/i?e eiioa?aioe?? «Nia?aiaiiua aii?inu iaoiaaiaca e
oa?aiee ini?eaca e ?ani?ino?ai?iiuo aeea?ae/aneeo aea?iaoicia» (Iineaa,
1998);

ee?i?/ieo eiioa?aioe?yo ? can?aeaiiyo eaoaae?e oe??ieo oa aaia?e/ieo
oai?ia AeiiAeIO (1997-1999??.);

can?aeaiiyo Aeiiaoeueeiai iaeaniiai oiaa?enoaa aea?iaoiaaia?ieia?a
(Aeiiaoeuee, 1997, 1998);

VII c’?cae? aea?iaoiaaia?ieia?a Oe?a?ie (Ee?a, 1999).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 12 iaoeiaeo
i?aoeue, cie?aia 4 aeo?iaeueieo noaoo?, 5 noaoae o ca??ieeao, 2 oace
aeiiia?aeae; ioi?ieaii aeiao?ae «Niin?a ciai?oiueiai e?eoaaiiy oai?eo ia
aoii?/iee aea?iaoeo o noaae?? aeeoy/i? aecaie».

Ianya oa no?oeoo?a aeena?oaoe??. ?iaioa neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy, 4 ?icae?e?a aeanieo
niinoa?aaeaiue, caeeth/ii? /anoeie, aeniiae?a, nieneo aeei?enoaieo
aeaea?ae, ui i?noeoue 139 a?o/eciyieo ? 150 ?iicaiieo. Oaeno
aeena?oaoe?? aeeeaaeaii ia 174 noi??ieao iaoeiiieno, ?ethno?iaaii 21
iaethieii, 22 oaaeeoeyie.

INIIAIEE CI?NO AeENA?OAOe?EII? ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. ?acoeueoaoe aeaii? ?iaioe
aacothoueny ia ee?i?ei-eaai?aoi?iiio ianoaaeaii? 167 oai?eo ia AAe a?eii
a?ae 4 i?nyoe?a aei 3 ?ie?a (93 ae?a/eiee ? 74 oeii/eea), c ieo iaiiaeyo
– 76, ae?oae ?aiiueiai a?eo – 91. O?eaae?noue caoai?thaaiiy neeaaeaea
a?ae 1 i?n. aei 3 ?ie?a. C ii/aoeo e?eoaaiiy aoei aeyaeaii nea?ae,
aiaiiac caoai?thaaiiy, i?iaiaeeeinue ?aoaeueia ee?i?/ia ianoaaeaiiy
iaoe??io?a. Aeey e?euee?niiai aecia/aiiy nooiaiy oyaeeino? i?ioeano
canoiniaoaaee ?iaeaen SCORAD, cai?iiiiiaaiee a?oiith a/aieo
?a?iiaenueeeo e?a?i.

Aecia/aee ooieoe?iiaeueio ni?iiiaei?noue O-e?ioioeeo?a oa ?oi?o
noaiiioeyoe?e, A-e?ioioeeo?a oeyoii ?aaeoe?? ?icaoeiooai?aiiy, ai?no
?ioiiaeiaoe?i?a A, M ? G, oaaioeeoa?io aeoeai?noue iaeo?io?e?a,
oaaioeeoa?iee ?iaeaen ? oano a?aeiiaeaiiy ieo?ineiueiai oao?acie?th
a?eueiei aioo??oiueiee?oeiiei eeniai (INO-oano). Aeine?aeaeoaaee
aeoeai?noue ne?iaaoeiaiai e?cioeeio ? ai?no oee?eoethth/eo ?ioiieo
eiiieaen?a (Oe?E). Ioe?ithaaee ca ?aaeoe??th ?ioiieaeeie?co nooi?iue
nainea?e?caoe?? ?ioiieiiiaoaioieo ee?oei aei 27 oa?/iaeo, iiaooiaeo,
ai?aea?iaeueieo, ieeeiaeo ? aaeoa??aeueieo aea?aai?a. ?ioaineai?noue
i?ioean?a e?iiia?ieneaeaoe?? (o 119 oai?eo: 57 a?oaeiiai oa 62 ?aiiueiai
aeeoy/iai a?eo) oa?aeoa?ecoaaee ca ai?noii ia?aeiiiai i?iaeoeoo IIE –
ae??iiaeo eii’thaao?a (AeE), aoi?eiiiai – iaeiiiaiai aeeaeueaeaa?aeo
(IAeA) e ?ioaa?aeueiei iieacieeii – ia?aeeniei aaiie?cii a?eo?ioeeo?a
(IAA). Aeey ioe?iee aioeieneaeaioii? aeoeaiino? aecia/aee ??aaiue
(-oieioa?ieo ye iieacieea iaoa?iaioaoeaii? eaiee; ai?no
noia?ieneaeaeeniooace (NIAe) e aeoeai?noue eaoaeace (Ea), ui
oa?aeoa?ecothoue oa?iaioaoeaio eaieo, ? caaaeueio aioeieenethaaeueio
aeoeai?noue ieacie e?ia? (AIA) – ?ioaa?aeueiee iieaciee. Ianoaaeaiiy
i?iaaaeai? a aeeiai?oe? aei oa i?ney e?eoaaiiy. Eiio?ieueio a?oio neeaee
34 caei?iaeo aeeoeie (14 iaiiaeyo oa 20 ae?oae ?aiiueiai a?eo).

C iaoith ooi/ieoe ?aaeueio ?iciianthaeaeai?noue aea?aiaea?iaoic?a, o
oiio /ene? AAe, o ae?oae aaeeeiai i?iieneiaiai ?aa?iio i?iaaaeaii
aieaooaaiiy aaouee?a 1000 ae?oae, ye? i?iaeeaathoue o Eae?i?inueeiio
?aeii? i. Aeiiaoeueea.

?ic?aooieiaa ? noaoenoe/ia ia?iaea ?acoeueoao?a aei??thaaiue, a oaeiae
?o a?ao?/ia ?ioa?i?aoaoe?y cae?eniai? ca aeiiiiiaith noaiaea?oiiai
iaeaoo i?eeeaaeieo i?ia?ai «Office Professional 97» o??ie «Microsoft
Corporation». Ia/eneai? cia/aiiy na?aaeiueiai a?eoiaoe/iiai (M),
na?aaeiueiai eaaae?aoe/iiai a?aeoeeaiiy (s), iiieeee aecia/aiiy
na?aaeiueiai a?eoiaoe/iiai (m), ??aaiue a??ia?aeiino? ?ica?aeiinoae (?)
ii??aithaaieo na?aaei?o a?oiiaeo ca aeiiiiiaith t-e?eoa??th No’thaeaioa,
eiao?oe??io ei?aeyoe?? (r).

Ci?no ?iaioe. Ca ?acoeueoaoaie aieaooaaiiy i?i iayai?noue oe??ieo
i?iya?a aea?a?? o ae?oae iia?aeiieee 43,5% ?aniiiaeaio?a (o 13,0% eeoa a
a?oaeiiio a?oe?, o 20,5% – i?ney ?ieo; o 10,0% – ye aei ?ieo, oae ?
i?ci?oa). 11,5% aaouee?a a?aei?/athoue iiyao oe??ieo aea?a?/ieo ?aaeoe?e
o ae?oae «ia??iaee/ii», «?ieiee» ? o.i., a 11,9% aecia/athoue ?o ye
«iino?ei?» aai «iaeaea iino?ei?»; o ?ioeo ae?oae oe? i?iyae
oa?aeoa?ecothoueny ye «iaeeie/iee ai?ciae». Oaeei /eiii, a?eueo i?ae o
40% i?iaieaoiaaieo ae?oae niinoa??aaeeny i?iyae aea?aiaea?iaoic?a, a
oiio /ene? o iieiaeie c ieo – ae?aaeai?. Aiae?c ?acoeueoao?a iieooaaiiy
o a?eiaeo a?oiao 0-6 ? 7-14 ?ie?a aeyaea, ui aea?a?/i? caoai?thaaiiy
oe??e /ano?oa cono??/athoueny na?aae aeioe?eueiee?a, iaeiae oey ??cieoey
ia aeinyaaea iaae? noaoenoe/ii? cia/ouino? (46,6(1,8% ? 41,9(2,0%).
Aeyaeaia ?ica?aei?noue, iaaii, iia’ycaia c ooieoe?iiaeueiith iac??e?noth
?ioiii? nenoaie o ae?oae ?aiiueiai a?eo. Na?aae aeioe?eueiee?a
aea?aiaea?iaoice o oeii/ee?a ? ae?a/aoie aecia/aeeny c iaeiaeiaith
/anoioith, oiae? ye oeiey?ie-aea?aee?a aoei cia/ii a?eueoa, i?ae
oeii/ee?a (48,7(2,9% ? 36,0(3,0%, ?<0,01). Oey a?aei?ii?noue ni?e/eieea ? cia/ouo ??cieoeth a ?iciianthaeaeaiino? aea?aiaea?iaoic?a na?aae ae?a/aoie oa oeii/ee?a o an?e aea??oe? (47,4(2,0% ? 39,8(2,1%, ?<0,01). Na?aae ae?oae, ye? aeaiaeiaoaaeeny a?oaeueie iaioa 3-o i?nyoe?a, aea?aiaea?iaoice aeieeaee a 48,0(2,9% aeiaaee?a. C? ca?eueoaiiyi oeeo oa?i?i?a /anoioa ?icaeoeo aea?a?/ieo ?aaeoe?e iaa?iaii i?iii?oe?eii ciaiooaaeany, nyaath/e oeeo?e 36,0(4,3% na?aae ae?oae, ye? iaea?aeoaaee a?oaeia aiaeoaaiiy a?ae iaeiiai aei i?aoi?a ?ie?a, ui a?aeiia?aea? ?acoeueoaoai U.M. Saarinen ? M. Kajosaari [1995]. No?iee i?eieiaiiy a?oaeiiai aiaeoaaiiy aeinoaiaiii ei?aethaaee c oa?i?iii aeieeiaiiy aea?a?/ieo ?aaeoe?e. Na?aae ooo/ii aeaiaeoaaieo c ia?iaeaeaiiy i?iyae, oa?aeoa?eciaai? aaoueeaie ye "aenoaeaoeaii-aea?a?/iee ae?aoac", aeieeaee ia ia?oiio ?ioe? aeeooy a 62,3(6,2% aeiaaee?a, na?aae oaeeo, ui i?eieieee iaea?aeoaaoe a?oaeia iieiei i?ney 6 i?nyoe?a – o 52,9(2,5%, na?aae oeo, ye? aeaiaeiaoaaeeny iei ??e ? a?eueoa – o 38,9(3,7%. Icia/ai? oaiaeaioe?? i?ine?aeeiaoaaeeny o aeiaaeeao caa?aaeaiiy a?oaeiiai aiaeoaaiiy aei i?aoi?a ?iee, ui aeicaiey? yeui ? ia ?aeiiaiaeoaaoe i?e?iaeia aeaiaeiaoaaiiy oaei? o?eaaeino?, aea, i?eiaeii?, ia ia?aoeiaeaeaoe eiio. An? ae?oe, ye? niinoa??aaeeny iaie, caiaaeoaeaee ia ia?oiio ?ioe? aeeooy, i?e/iio 142 (85,0%) – a ia?oiio i?a??//?, ui ocaiaeaeo?oueny c aeaieie A.I. Iaiiaiiaa [1987], I.I. Oi?iiiaie, I.A. Neiyaneie [1993]. Na?aaei?e a?e ii/aoeo caoai?thaaiiy neeaa 4,9 i?nyoey. O 139 (83,2%) oai?eo anoaiiaeaii niaaeeiaa iaoyaeaiiy, caeaa?eueoiai ca iaoa?einueeith e?i??th, ui a?aeiia?aea? iiaeyaeai ?ioeo aeine?aeiee?a [Eiaeeioeiaa I.E., 1985; Iaiiaiia A.I., 1987; Matsuoka S. et al., 1999]. 116 ae?oae (69,5%) iaee iaoiaaiaoe/ii cia/ou? ii?ooaiiy a aioaiaoaeueiiio e ?io?aiaoaeueiiio ia??iaeao, ui aaciina?aaeiuei iiaei aieeiooe ia noaiiaeaiiy ?ioiii? nenoaie ieiaea, a oaeiae i?ecaanoe aei ooieoe?iiaeueii? iac??eino? aaeaioaoe?eieo iaoai?ci?a o iiaiia?iaeaeaiiai. O 52 (31,1%) ae?oae a?aei?/aii noiooi? niiaoe/i? caoai?thaaiiy aea?a?/ii? i?e?iaee, i?e/iio o an?o oai?eo ?oiueiio aeieeiaiith ia?aaeoaaee i?iyae AAe. Na?aae ?ioeo ia?aianaieo caoai?thaaiue iaea?eueo /anoi cono??/aeeny A?A? – o 127 oai?eo (76,0%), aeenaaeoa??ic (a o. /. aeyaeaiee oeyoii oe?eani?yiiaaiiai ianoaaeaiiy) – o 48 (28,7%), aioa?ieie?o – o 17 (10,2%), aeene?iac?? aeia/iaea?aeieo oeyo?a – o 19 (11,4%), aaeuei?ioice – o 24 (14.4%). Ne?ae a?aecia/eoe a?eueo ?aii? aeieeiaiiy iaoieia?? i?aai?a o?aaeaiiy o iaoeo oai?eo o ii??aiyii? c aeaieie A.I. Iaiiaiiaa [1987], I.I. Oi?iiiaie, I.A. Neiyaneie [1993]. Noiooi? caoai?thaaiiy iii?oii iaoyaeoaaee ia?aa?a oe??iiai i?ioeano, ui iaaoaaa a?eueo iioe?aiiai oa?aeoa?o ? noaaaa ?acenoaioiei aei oa?ai??. Ee?i?/i? oi?ie AAe anoaiiaethaaeenue o a?aeiia?aeiino? aei eeaneo?eaoe?? A.A. Aioiiueaaa oa ni?aaao. o iiaeeo?eaoe?? A.I. Iaiiaiiaa [1987]. Aenoaeaoeaio oi?io niinoa??aaee o 64 oai?eo, a o. /. 36 – a?oaeiiai ? 28 – ?aiiueiai aeeoy/iai a?eo. A?eoaiaoicii-neaaiicio oi?io aeyaeee o 76 oai?eo (40 iaiiaeyo ? 36 ae?oae ?aiiueiai a?eo). A?eoaiaoicii-neaaiicia oi?ia c e?oai?caoe??th a?aei?/aia o 18, e?oaii?aeia – o 2 ? i?o?ea?iicia – o 7 ae?oae ?aiiueiai a?eo. ?iaeaen SCORAD o oai?eo aa??thaaa ?iaeea?aeoaeueii a?ae 19 aei 74 aae?a, neeaaeath/e a na?aaeiueiio 36,3(3,9 aaea. A ?acoeueoao? aea/aiiy ?ioiiiai noaoono aeyaeaii iiieaeai? iieacieee ee?oeiii? eaiee o a?eueoi? /anoeie oai?eo iaio a?eiaeo a?oi. Na?aaei?e ai?no eaeeioeeo?a neeaaeaa o iaiiaeyo c AAe 8,5(0,3 A/e, oai?eo ?aiiueiai aeeoy/iai a?eo – 7,2(0,3 A/e, ui a??ia?aeii ieae/a iieaciee?a caei?iaeo ae?oae (a?aeiia?aeii 10,3(0,2 ? 9,3(0,2 A/e). A?aei?/aii oaiaeaioe?th aei cieaeaiiy ??aiy e?ioioeeo?a o oai?eo ae?oae. A oie /an ye ??cieoey a?aeiinieo iieaciee?a o oai?eo ia AAe ? caei?iaeo ae?oae iaaeinoia??ia, i?e ii??aiyii? aaniethoieo cia/aiue na?aaeiy e?euee?noue e?ioioeeo?a cia/ii ciaioaia (o iaoe??io?a a?oaeiiai a?eo 4,4(0,6, ?aiiueiai aeeoy/iai – 3,4(0,5 A/e; o eiio?ieueieo a?oiao – 5,8(0,2 oa 4,7(0,4 A/e). O oai?eo ia AAe oaeiae aoea cieaeaia e?euee?noue A-?icaoeiooai?thth/eo ee?oei (a?aeiia?aeii 27,9(3,5% ? 30,0(2,3% a ii??aiyii? c 48,8(1,1% oa 62,5(0,9% o eiio?ie?, oiaoi iaeaea aaea?/?). Aiaeia?/i? ?acoeueoaoe o aei?ineeo oai?eo iaea?aeaee I.A. Ei/a?aei ? ni?aaao. [1977], E. Andersen ? N. Hjorth [1975] oa ?i. Iacaaaeath/e ia aeinoaiaiia ciaioaiiy ai?noo oaio?e?i?acenoaioii? oa oaio?e?i/ooeeai? noaiiioeyoe?e aei 20,8(2,1% ? 7,8(1,0% o iaiiaeyo, 22,7(1,6% ? 9,1(1,6 a ?aiiueiio aeeoy/iio a?oe?, ?ioii?aaoeyoi?iee ?iaeaen oai?eo ia AAe (a?aeiia?aeii 2,7(0,3 ? 2,5(0,4) ?noioii ia a?ae??ciyany a?ae eiai cia/aiiy o caei?iaeo ae?oae (2,9(0,2 ? 2,8(0,2). E.I. Noai?iaa [1989], D.Y.M. Leung et al. [1981], iaaiaee, aeyaeee ca?eueoaiiy ?ioii?aaoeyoi?iiai ?iaeaeno i?e AAe, aea na?aae aei?ineeo oai?eo. Aiae?c iieaciee?a aoii?aeueiiai ?ioi?oaoo i?e AAe aeyaea ??ciini?yiiaai?noue eiai ci?i. O 25 (15,0%) ianoaaeaieo ae?oae a?aei?/aii cieaeaiiy ai?noo A-e?ioioeeo?a, ?io? 85,0% oai?eo iaee iieacieee a iaaeao ii?ie, a na?aaei? cia/aiiy o a?oiao ca a?eii a??ia?aeii ia a?ae??ciyeeny a?ae a?aeiia?aeieo iieaciee?a caei?iaeo ae?oae. Eeoa o 31 (18,6%) oai?iai niinoa??aaeeny ii?iaeuei? iieacieee ?ioiiaeiaoe?i?a on?o aeine?aeaeaieo eean?a. Aeey ?ioeo ae?oae c AAe oeiiaeie aoee ??ciiiai?oi? aa??aioe aeen?ioiiaeiaoe?iai??. Cieaeaiiy IgG a ne?iaaooe? e?ia?, aeyaeaia o 68 (40,7%) oai?eo, niieo/aeiny ?c noiooiueith iaoieia??th i?aai?a o?aaeaiiy o 59 c ieo ?, iiaeeeai, iiynith?oueny aeniaaeaiiyi ooieoe?iiaeueii? aeoeaiino? ieaciaoe/ieo ee?oei i?ae aieeaii ina?aaee?a o?ii?/ii? ?ioaeoe??. A?aei?/aia oaiaeaioe?y aei i?aeaeuaiiy ??aiy ne?iaaoeiaiai IgA o /anoeie oai?eo, yea aoea iniaeeai ae?aaeaia o a?oaeiiio a?oe? ? ii?aeioaaeanue c aenieith oa?/iaith nainea?e?caoe??th aei 2-3 aea?aai?a. Ai?no IgM o a?eueoino? ae?oae ciaoiaeeany o iaaeao a?eiai? ii?ie. A on?o aeiaaeeao i?aeaeuaiiy IgM a?aei?/aii o iaiiaeyo c iaaaeeeith aeaai?noth caoai?thaaiiy (iaio 6 i?nyoe?a) ? a?aeiia?aea? o?c?ieia?/ii caeiiii??i?e ?aii?e ?ioii?e a?aeiia?ae? ia aioeaaiiee aieea. Ii?ooaiiy a oaaioeeoa?i?e nenoai?, ui iieyaathoue o cieaeaii? a?aenioea oaaioeeooth/eo ee?oei oa/aai oaaioeeoa?iiai ?iaeaeno, aeyaeaii o an?o ianoaaeaieo oai?eo. Aeoeai?noue oaaioeeoico aoea ieae/a ii?iaeueieo cia/aiue o 26 (34,2%) ae?oae a?oaeiiai oa 38 (41,8%) – ?aiiueiai a?eo; a?aei?/aii cieaeaiiy oaaioeeoa?iiai ?iaeaeno a?aeiia?aeii o 59 (77,6%) ? 89 (97,8%) oai?eo aeaieo a?oi. Caa?oa? oaaao ae?aaeai?noue i?eai?/aiiy oaaioeeoa?ii? eaiee – na?aaei? cia/aiiy oaaioeeoa?iiai ?iaeaeno aoee iaeaea aaea?/? ieae/eie ca aiaeia?/i? iieacieee caei?iaeo ae?oae (o iaiiaeyo – a?aeiia?aeii 2,2(0,4 ? 4,2(0,1; a ?aiiueiio aeeoy/iio a?oe? – 2,2(0,1 ? 4,6(0,1). Oe? ?acoeueoaoe ni?aiaaeathoue c aeaieie I.I. Oi?iiiaie oa ni?aaao. [1993], i?ioa nooi?iue oeeo ii?ooaiue o iaoeo oai?eo aoa cia/ii aeuei. A oie aea /an iieacieee INO-oanoo, ui oaeiae oa?aeoa?eco? oaaioeeoa?io ooieoe?th, aeyaeeeny ca?eueoaieie o 67 (88,2%) oai?eo ia AAe iaiiaeyo ? 83 (91,2%) ae?oae ?aiiueiai a?eo, o ?ioeo eiai cia/aiiy aoee ii?iaeueieie. I?aeaeuaiiy ??aiy Oe?E a?aei?/aia o 47 (61,8%) oai?eo a?oaeiiai oa 89 (97,8%) ?aiiueiai aeeoy/iai a?eo, ei?aethaaei ?c o?eaae?noth oe??iiai i?ioeano ? a?aeiia?aea? ?ioeo aeaiei [Aeooaiueeee A.O., A?aiaei N.A., 1990]. O 146 (87,4%) oai?eo aeyaeaii i?aeaeuaiee ai?no e?cioeeio, ui ia ocaiaeaeo?oueny c aeaieie I.I. Oi?iiiaie oa ni?aaao. [1986]. C o?aooaaiiyi oiai, ui e?cioeei ni?ey? ii?ooaiith oe?e?niino? ee?oeiieo iaia?ai ?, ye iane?aeie, a?eueo eaaeiio i?iieeiaiith ? a?aeeeaaeaiith Oe?E a oeaieiao, ie aaaaea?ii, ui i?aeaeuaiiy eiai ??aiy i?e AAe a noaae?? caaino?aiiy ? ia?ea?ii aeoeaiino? i?ioeano. Iaie ia aeyaeaii ?noioieo a?aei?iiinoae ?ioiieia?/ieo iieaciee?a a caeaaeiino? a?ae ee?i?/ii? oi?ie caoai?thaaiiy. Aiae?c aea?a?/ii? ?aaeoeaiino? iieacaa caeaaei?noue e?eueeino? i?e/eiii-cia/oueo aea?aai?a a?ae oa?i?io caoai?thaaiiy: aeey oai?eo c iaaaeeeith aeaai?noth aea?iaoico (ye i?aaeei, iaiiaeyo) aoea oa?aeoa?ia ie?aiaaeaioia nainea?e?caoe?y; i?e ca?eueoaii? o?eaaeino? aeieeaea iie?aaeaioia aea?a?y. Aenieee nooi?iue nainea?e?caoe?? aei iaeiiai ? a?eueoa aea?aai?a niinoa??aaany o 138 (82,6%) ianoaaeaieo, a oiio /ene? aei i'youeio ? a?eueoa aea?aai?a - o 37 (22,2%). Oa?/iaa nainea?e?caoe?y a?aei?/aia o an?o oai?eo. Aaeoa??aeueia aea?a?y niinoa??aaeany o 82 (49,1%) ae?oae, i?e oeueiio noao?eieie aeyaeany iae?iciianthaeaeai?oei aea?aaiii – nainea?e?caoe?y aei iueiai a ??ci?e i??? aeyaeaia o 105 (62,9%) oai?eo, a oiio /ene? aenieiai ? na?aaeiueiai nooiaiy – o 65 (38,9%). O 85 (50,9%) ae?oae niinoa??aaeany aea?a?y ia ieeie ao?'yi?a aai aea?aa, o 55 (32,9%) – ia ai?aea?iaeuei? oa o 80 (47,9%) – aei iiaooiaeo aea?aai?a. I?e aiae?c? aea?a?/ii? ?aaeoeaiino? i?e AAe aeyaeaia a?eiaa noaae?ei?noue nainea?e?caoe??. Oa?/iaa nainea?e?caoe?y, yea niinoa??aaeany o an?o oai?eo iaiiaeyo, na?ae/eoue, ui iae/ano?oei ? iae?iia??i?oei aeaea?aeii iaaeoiaeaeaiiy aea?aai?a aei i?aai?cio ae?oae i?e ia?oeo iai?oanoaoe?yo aea?iaoico ? oeoieiai-eeoeiaee o?aeo. Iae?iciianthaeaeai?oeie aea?aaiaie aoee ei?ia'y/a iieiei, eo?y/? yeoey, i'yni ea/ee, a?a/aia ? ?eniaa e?oie. Aaeoa??aeueia, ieeeiaa, ai?aea?iaeueia oa iiaooiaa nainea?e?caoe?y o oai?eo iaiiaeyo cono??/aeeny ??aeoa: ia ?aii?o aoaiao ?icaeoeo AAe aiie a?ae?a?athoue iaioo ?ieue. O oai?eo ia AAe ae?oae ?aiiueiai a?eo aeyaeaii a?eueo ae?aaeai? ci?ie aea?a?/ii? ?aaeoeaiino?, ui i?iyaeyeeny iie?aaeaioiith nainea?e?caoe??th, a oiio /ene? aaeoa??aeueiith, ieeeiaith, ai?aea?iaeueiith oa iiaooiaith. Aiaeii/an i?aeoe/ii aeey an?o oai?eo aoea oa?aeoa?ia oa?/iaa iie?aea?a?y. Iae/ano?oa aeyaeyeany nainea?e?caoe?y aei a?anyii?, a?a/aii? ? ?eniai? e?oi, naeieie, i'yna eo?ee, ei?ia'y/iai iieiea ? eo?y/eo y?oeue. I?e/eiii-cia/oua nainea?e?caoe?y aei ee?u?a ?iaeo aea?iaoioaai?aean, ye?e P. Meglio et al. [1996], R.A. Tupker et al. [1996] a?aeaiaeyoue aaeeeo ?ieue o iaoiaaiac? AAe, aeyaeaia eeoa o 10 (11,0%) oai?eo ?aiiueiai aeeoy/iai a?eo. ?iaeea?aeoaeueiee niaeo? i?e/eiii-cia/oueo aea?aai?a o eiaeii? aeeoeie na?ae/eoue i?i i?aeoe/io ia?aaeuei?noue ?nioth/eo caaaeueieo ?aeiiaiaeaoe?e ae?i?iaoe?eiiai oa?aeoa?o oa i?aee?aneth? iaiao?aei?noue iaia'yceiaiai aea?aieia?/iiai ianoaaeaiiy c iaoith ei?aeoe?? ae??oe ? ?ic?iaee caoiae?a i?io?eaeoeee iaaeoiaeaeaiiy aea?aai?a aei i?aai?cio oai?iai. I?e aeine?aeaeaii? i?ioean?a e?iiia?ieneaeaoe?? o oai?eo ia AAe aeyaeaii i?aeaeuaiee ai?no ye i?ii?aeieo, oae ? aoi?eiieo i?iaeoeo?a IIE. ??aaiue AeE ia?aaeuoaaa ii?iaeuei? cia/aiiy o 52 (91,2%) oai?eo iaiiaeyo ? 59 (95,2%) ae?oae ?aiiueiai a?eo, a o 18 (31,6%) ? 27 (43,5%) ae?oae a 1,7 ? a?eueoa ?ac?a ia?aaa?ooaaa na?aaei? iieacieee a eiio?ieueieo a?oiao. Aeyaeaiee i?yiee ei?aeyoe?eiee ca'ycie ??aiy AeE ? cia/aiiy INO-oanoo, iiaeeeai, na?ae/eoue, ui aeaoaeoe oaaioeeoa?ii? eaiee i?ecaiaeyoue aei eiiiainaoi?ii? a?ia?aeoeaaoe?? "ieenethaaeueiiai oaaioeeoico" ?, ye iane?aeie, ia?aeeniiai iioeiaeaeaiiy ee?oeiieo iaia?ai aeanieo oeaiei. ??aaiue IAeA ia?aaeuoaaa ii?iaeuei? cia/aiiy o 54 (94,7%) oai?eo a?oaeiiai ? 62 (100,0%) ?aiiueiai aeeoy/iai a?eo. Iacaaaeath/e ia aeinoia??ii a?eueo iecuee? na?aaei? iieacieee (-oieioa?ieo o oai?eo ia AAe o ii??aiyii? c? caei?iaeie (5,33(0,15 ? 5,18(0,19 o oai?eo oa 6,50(0,11 ? 6,98(0,23 ieiieue/e o eiio?ieueieo a?oiao), eiai cia/aiiy, ui ia aeeaaeathoueny aei iaae a?eiai? ii?ie, a?aei?/ai? eeoa o 4 ae?oae. Aiaeia?/i? ca ae?aaeai?noth, aea i?ioeeaaeii ni?yiiaai? ci?ie aoee i?eoaiaii? IAA, ui, ye a?aeiii, oa?aeoa?eco? ia?ieneaeaoe?th, aeeeeeaio a ia?oo /a?ao iaaeinoaoi?noth aioeieneaeaioii? aeoeaiino? oieioa?ie?a. N.A. Noieaiaa ? A.I. *eia?ia [1987] oaeiae a?aei?oeee a?aeiia?aeiee ii?i? ai?no a?oai?io A o oai?eo ia aenoaeaoeaii-ei?eiao e a?eoaiaoicii-neaaiicio oi?ie AAe, ye? caeaa?eueoiai cono??/aeeny ? a iaoeo ae?oae. Iaaii, a a?oaeiiio oa ?aiiueiio aeeoy/iio a?oe? i?e o?eaaeino? caoai?thaaiiy aei 3 ?ie?a ua ia anoeaa? ?icaeiooeny yaia iaaeinoaoi?noue a?oai?io A, oi/a ? niinoa??aa?oueny oaiaeaioe?y aei ciaioaiiy eiai ai?noo. Iieacieee oa?iaioaoeaii? eaiee aioeieneaeaioiiai caoenoo oa?aeoa?ecoaaeeny a?eueo ae?aaeaiei cieaeaiiyi. O oai?eo iaio a?eiaeo a?oi niinoa??aaeiny aeinoia??ia ciaioaiiy ai?noo NIAe ? aeoeaiino? Ea o ii??aiyii? c? caei?iaeie ae?oueie. I?e oeueiio o iaoe??io?a ?aiiueiai aeeoy/iai a?eo ?o na?aaei? cia/aiiy (a?aeiia?aeii 0,38(0,004 iae./ia a?eea oa 14,67(1,34 ieao/e) aoee iaioeie ca ieaeith iaaeo a?eiai? ii?ie. Cia/aiiy ?ioaa?aeueiiai iieacieea AIA o oai?eo iaiiaeyo neeaee 43,53(1,15%, ae?oae ?aiiueiai a?eo – 40,26(1,13%, ui a??ia?aeii ieae/a a ii??aiyii? c? caei?iaeie iaeiie?oeaie, ? iaa?oue ia aeeaaeaeiny o iaae? ii?iaeueieo (45-55%). sse aeyaeeiny, ?yae iieaciee?a a?eueii?aaeeeaeueii? e aioeieneaeaioii? nenoai iia'ycaiee c oyaee?noth ia?aa?ao AAe: i?yia caeaaei?noue a?ae ?iaeaeno SCORAD aoea oa?aeoa?ia aeey ai?noo AeE, a cai?ioia – aeey ??aiy NIAe, aeoeaiino? Ea e AIA. Aeey aecia/aiiy nooiaiy ae?aaeaiino? ii?ooaiue o nenoai? IIE – aioeieneaeaioiee caoeno ? aoaeoeaiino? e?eoaaeueieo caoiae?a iaie cai?iiiiiaaii ?iaeaen Niieo/aiino? Ieenethaaeueieo Nenoai (?NIN). A?i ?ic?aoiaoaaany, aeoiaey/e c ii?iiaaieo aei na?aaei?o cia/aiue caei?iaeo ae?oae iieaciee?a i?i- oa aioeieenethaaeueii? nenoai – IAeA+AeE+IAA/NIAe+Ea+AIA. O caei?iaeo ae?oae ?NIN iaaeeaeaany aei 1 ? neeaaeaa o iaiiaeyo 1,01(0,08, o ?aiiueiio aeeoy/iio a?oe? – 1,03(0,07. O oai?eo ia AAe iaio a?eiaeo a?oi ?NIN ia?aaa?ooaaa a?aeiia?aeiee iieaciee caei?iaeo iaeiie?oe?a, i?e/iio a ?aiiueiio aeeoy/iio a?oe? a?eueo i?ae a 2,5 ?aca, ? aei??aithaaa a?aeiia?aeii 1,92(0,16 ? 2,55(0,21. Iaie aeae?eaia a?oia oai?eo c iaea?eueo ae?aaeaieie ci?iaie c aieo a?eueii?aaeeeaeueii? e aioeieenethaaeueii? nenoai. Aei oe??? eaoaai??? ie a?aeianee ae?oae c ?NIN>2,0. Oae? cia/aiiy ?iaeaeno aoee
a?aei?/ai? o 82 oai?eo iaio a?eiaeo a?oi (22 (38,6%) iaiiaeyo ? 60
(96,8%) ae?oae ?aiiueiai a?eo). Na?aaeiy o?eaae?noue ia?aa?ao aea?iaoico
o ae?oae aeaii? a?oie aei??aithaaea 1,85(0,32 ?iee. Iieaciai, ui iniiaio
iano oaeeo oai?eo neeaee ae?oe ?aiiueiai a?eo. Oyaee?noue caoai?thaaiiy
ca oeaeith SCORAD eieeaaeany a?ae 33 aei 56 aae?a ? aei??aithaaea a
na?aaeiueiio 38,3(2,4 aaea, ui aeinoia??ii ia?aaeuo? cia/aiiy oeueiai
iieacieea o oai?eo, ye? ia oa?eoee aei icia/aii? a?oie (31,6(2,0). Oea
aeicaiey? i?eioneaoe, ui i?aeaeuaiiy IIE ? i?eai?/aiiy aeoeaiino?
aioeieneaeaioii? nenoaie neeuei?oa ae?aaeaia o oai?eo ye c a?eueoith
aeaai?noth aea?iaoico (oiaoi c o?aooaaiiyi caeiiii??iinoae i?iyao AAe a
a?eueo noa?oee a?eiaee ia??iae – o ?aiiueiio aeeoy/iio a?oe?), oae ? i?e
ca?eueoaii? oyaeeino? ia?aa?ao AAe.

Aeine?aeaeaiiy ca’yceo ?ioiiiai noaoono ? a?eueii?aaeeeaeueiiai
ieeneaiiy e?i?ae?a aeyaeei aeinoia??io iiceoeaio ei?aeyoe?eio
caeaaei?noue iii?ae ai?noii AeE, ne?iaaoeiaiai e?cioeeio ? cia/aiiyie
INO-oanoo, ??aiai IAeA ? ai?noii Oe?E. Oaeiae aeyaeaiee cai?ioiee
ca’ycie ??aiy NIAe, aeoeaiino? Ea e AIA c ai?noii Oe?E. Ca iaoith
aeoieith, ai?no AeE ? e?cioeeio iiaeooue aeei?enoiaoaaoeny aeey
oa?aeoa?enoeee aeoeaiino? i?ioeano, a iaeiie/aiiy IAeA ? Oe?E – eiai
aeaaiino?.

Eiiieaenia oa?ai?y oai?eo ia AAe i?iaiaeeeany c o?aooaaiiyi ee?i?/ii?
oi?ie aea?iaoico, ?iciianthaeaeaiino? i?ioeano, iayaiino? noiooi?o
caoai?thaaiue, ?acoeueoao?a ianoaaeaiiy. Oai?? eiaeii? a?eiai? eaoaai???
aoee iiae?eai? ia 4 i?aea?oie a a?aeiia?aeiino? c oa?ai??th, ui
i?iaiaeeeany (anueiai 8 i?aea?oi). Ae?oyi I ? V i?aea?oi i?ecia/aee
o?aaeeoe?eia e?eoaaiiy: eeneiiiei/ii-?ineeiia ae??oa ca aeiyoeii
iae?aaoieo ? ?iaeea?aeoaeueieo i?e/eiii-cia/oueo aea?aai?a, aeyaeaieo
i?e aea?aieia?/iiio ianoaaeaii?, aioea?noai?ii? i?aia?aoe, naaeaoeai?
caniae, ciai?oi? e?eoaaiiy. Iaea?aeai? aeai? i?i cia/aiiy ?ioiieo
ii?ooaiue o iaoiaaiac? AAe o ae?oae noaee i?aenoaaith aeey aeeth/aiiy
aei eiiieaenii? o?aaeeoe?eii? oa?ai?? II ? VI i?aea?oi ?ioiiiiaeoeyoi?a
?ineeiiiai iioiaeaeaiiy aaeieaio. A?i yaey? niaith i?aia?ao a?ieia?/ieo
aeoeaieo eiiieaen?a ei?e aeoaa ? a aeicao 48-1200 iea/ea iane o?ea
i?iyaey? ?ioiinoeioethth/o ? aeoeaoth/o iieacieee ianiaoeeo?/ii?
?acenoaioiino? i?aai?cio ae?th. Aeyaeai? ci?ie aea?a?/ii? ?aaeoeaiino?
oa i?ioean?a IIE noaee i?aenoaaith aeey aeeth/aiiy a eiiieaenio oa?ai?th
oai?eo III ? VII i?aea?oi iaia?aiinoaa?e?caoi?a eaoioeoaio. Oeae
i?aia?ao caeaoiee ca’ycoaaoe eaeueoe?e ? i?e aca?iiae?? c a?eeaie
eaeueoe??aeo eaiae?a «caieeaoe» ?o, aeieoth/e oaeei /eiii ca?eueiaiiy
oo/ieie ee?oeiaie iaae?aoi??a aea?a?? – a?noai?io, na?ioii?io oa ?i.
Oai?ei IV ? VIII i?aea?oi i?ecia/aee eiiieaenia e?eoaaiiy c
aeei?enoaiiyi iaio i?aia?ao?a. I?aenoaaith aeey aeeth/aiiy a oa?ai?th
aaeieaio, ie??i aeyaeaieo ii?ooaiue ?ioiiiai noaoono, aoa iiceoeaiee
?acoeueoao oanoo c aecia/aiiyi /ooeeaino? ?ioiieiiiaoaioieo ee?oei aei
oeueiai i?aia?aoo in vitro. Aaeieai i?ecia/aany ia?i?aeueii o aeaeyae?
ii?ioeo c ?ic?aooieo 1 ia/ea iane o?ea 1 ?ac o aeaiue ia i?ioyc? 21
aeiy. Ia?aiini?noue i?aia?aoo a iaio a?eiaeo a?oiao aoea aeia?ith,
oneeaaeiaiue ia niinoa??aaeiny. Eaoioeoai i?ecia/aany o aeaeyae?
oaaeaoie aai ne?iio c ?ic?aooieo 0,025 ia/ea aea?/? ia aeiao ia i?ioyc?
30 aei?a. A ?acoeueoao? eiai aaeeaaiiy oneeaaeiaiue ia a?aei?/aee.
?aeeiei «iia?/iei» aoaeoii aoa naaeaoeaiee, ui niinoa??aaany o 5 (6,2%)
ae?oae, i?e/iio aaoueeaie oea ioe?ithaaeinue iiceoeaii.

I?i aoaeoeai?noue e?eoaaiiy noaeeee ia i?aenoaa? aeeiai?ee ee?i?/ieo
neiioii?a AAe o c?noaaeaii? c iieacieeaie ?ioiiiai noaoono ?
e?iiia?ieneaeaoe??.

Aiae?c iaeaeeae/eo ?acoeueoao?a oa?ai?? ae?oae I ? V i?aea?oi, ye?
iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy, iieacaa, ui ee?i?/ia aeaeoaeaiiy
ianoaei o e?ioe? eo?no o 37,2% ae?oae, a o. /. 45,0% iaiiaeyo ? 30,4%
ae?oae ?aiiueiai a?eo, cia/ia iie?ioaiiy a?aei?/aii o 34,9% oai?eo
(a?aeiia?aeii 45,0% ? 26,1%). Iie?ioaiiy niinoa??aaeiny o 20,9% (10,0% ?
30,4%). A?aenooi?noue aoaeoo a?aei?/aia o 3 oai?eo ?aiiueiai aeeoy/iai
a?eo (7,0% c on?o, ui iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy, a o. /. 13,0%
ae?oae aeaii? a?eiai? i?aea?oie). O II ? VI i?aea?oiao oai?eo, ye?
iaea?aeoaaee aaeieai, aeaeoaeaiiy a?aei?/aii o 67,4% (84,2% ae?oae
a?oaeiiai ? 54,2% ?aiiueiai a?eo), cia/ia iie?ioaiiy – o 20,9% (15,8% ?
25,0%), iie?ioaiiy – o 5 ae?oae ?aiiueiai a?eo (11,6% c on?o, ui
iaea?aeoaaee e?eoaaiiy c aaeieaiii, a o. /. 20,8% ae?oae aeaii? a?eiai?
i?aea?oie). I?e aeei?enoaii? a eiiieaeniiio e?eoaaii? eaoioeoaio (III ?
VII i?aea?oie) iiaia ee?i?/ia ?ai?n?y eiinoaoiaaia o 71,4%, cie?aia o
78,9% iaiiaeyo ? 65,2% ae?oae ?aiiueiai a?eo; cia/ia iie?ioaiiy – o
21,4% (a?aeiia?aeii 21,1% ? 21,7%). Iie?ioaiiy a?aecia/aia o 3 oai?eo
?aiiueiai aeeoy/iai a?eo (7,1% c on?o, ui iaea?aeoaaee e?eoaaiiy c
eaoioeoaiii, a oiio /ene? 13,0% ae?oae aeaii? a?eiai? i?aea?oie). Na?aae
oai?eo IV ? VIII i?aea?oi, ye? iaea?aeoaaee a eiiieaeni?e oa?ai?? ye
aaeieai, oae ? eaoioeoai, niinoa??aaeeny iaee?au? iaeaeeae/? ee?i?/i?
?acoeueoaoe: aeaeoaeaiiy a?aei?/aii o 89,7% (94,4% a?oaeiiai ? 85,7%
?aiiueiai a?eo), o ?ioeo 10,3% – cia/ia iie?ioaiiy (a?aeiia?aeii 5,6% ?
14,3%).

Ii??aiyeueiee aiae?c na?aaei?o cia/aiue ?iaeaeno SCORAD i?ney e?eoaaiiy
aeaiiino?o? eiai iaea?eueo aenie? cia/aiiy o i?aea?oiao c o?aaeeoe?eiei
e?eoaaiiyi (I – 5,2(0,5 ? V – 7,4(0,7), ui iiynith?oueny a?eueoith
e?euee?noth oai?eo c iaeaeeae/eie ?acoeueoaoaie e?eoaaiiy, ioe?iaieie ye
«iie?ioaiiy» ? «a?aenooi?noue aoaeoo». A ?ioeo i?aea?oiao cia/aiiy
SCORAD aoee a??ia?aeii iaioeie ? a?aeiia?aeaee e?auei iaeaeeae/ei
?acoeueoaoai. Iaea?eueo iecueeeie cia/aiiyie ?iaeaeno oa?aeoa?ecoaaeeny
IV (1,1(0,1) ? VIII (1,3(0,1) i?aea?oie, a yeeo oai?? iaea?aeoaaee
eiiieaenia e?eoaaiiy c aeei?enoaiiyi aaeieaio ? eaoioeoaio, ui
i?aeoaa?aeaeo? a?eueoo ee?i?/io aoaeoeai?noue ii?aeiaiiy icia/aieo
i?aia?ao?a.

O i?aea?oiao, ui iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy oa oa?aiaaoe/iee
eiiieaen c eaoioeoaiii, a?aei?/aia oaiaeaioe?y aei i?aeaeuaiiy
e?eueeino? eaeeioeeo?a, e?ioioeeo?a, O-e?ioioeeo?a, oaio?e?i/ooeeaeo ?
oaio?e?i?acenoaioieo ee?oei o ii??aiyii? c a?aeiia?aeieie iieacieeaie
aei e?eoaaiiy, ui iaeiae ia aeinyaaea noaoenoe/ii? a??ia?aeiino?. O
i?aea?oiao, ui iaea?aeoaaee ii?yae c eiiieaeniith oa?ai??th aaeieai (II,
IV, VI, VIII), niinoa??aaeiny i?aeaeuaiiy iieaciee?a ee?oeiiiai
?ioi?oaoo, i?e oeueiio aeaye? c ieo (e?euee?noue eaeeioeeo?a,
e?ioioeeo?a) i?ney e?eoaaiiy ia a?ae??ciyeeny a?ae a?aeiia?aeieo
iieaciee?a caei?iaeo iaeiie?oe?a. E?euee?noue A-?icaoeiooai?thth/eo
ee?oei aeinoia??ii ia?aaeuoaaea ?oi?e ai?no aei e?eoaaiiy eeoa o a?oiao,
ui iaea?aeoaaee a eiiieaeniiio e?eoaaii? iaeaeaa i?aia?aoe, ? neeaaeaea
a IV i?aea?oi? – 39,34(4,22%, o VIII – 40,49(4,65%, aea ia aeinyaaea
cia/aiue caei?iaeo ae?oae. E?euee?noue oaio?e?i/ooeeai? oa
oaio?e?i?acenoaioii? noaiiioeyoe?e e?ioioeeo?a i?ney e?eoaaiiy
noaoenoe/ii aeinoia??ii ca?eueoeeany a oeeo aea i?aea?oiao, aea ana-oaee
caeeoaeany ieae/a cia/aiue o caei?iaeo iaeiie?oe?a. Ia aeyaeaii
a??ia?aeieo a?aei?iiinoae ?ioii?aaoeyoi?iiai ?iaeaeno aei oa i?ney
e?eoaaiiy ai? a iaei?e c i?aea?oi; eiai cia/aiiy a?aeiia?aeaee
iieacieeai o caei?iaeo ae?oae.

Na?aaei?e ai?no A-e?ioioeeo?a i?ney e?eoaaiiy ia caciaa ?noioieo ci?i
ai? a iaei?e c i?aea?oi, aeinoia??ii ia a?ae??ciyth/enue a?ae iieaciee?a
aei e?eoaaiiy ? a?aeiia?aeath/e cia/aiiyi o caei?iaeo ia?aaaniee?a.
Iacaaaeath/e ia oaiaeaioe?th aei cieaeaiiy ai?noo IgA a iaio a?eiaeo
a?oiao i?e an?o aeaeao oa?ai??, o?eueee o ae?oae ?aiiueiai a?eo aiie
aeinyaee iieaciee?a caei?iaeo ae?oae ? eeoa o VIII i?aea?oi? a??ia?aeii
a?ae??ciyeeny a?ae cia/aiue aei e?eoaaiiy (0,90(0,19 a/e). Ia a?aei?/aii
cia/ieo ci?i na?aaeiueiai ??aiy IgM ? IgG a on?o i?aea?oiao i?ney
e?eoaaiiy: ia niinoa??aaeiny noaoenoe/ii a??ia?aeii? ??cieoe? ai? c
?acoeueoaoaie aei e?eoaaiiy, ai? c iieacieeaie caei?iaeo ae?oae. I?ae
oei, iacaaaeath/e ia a?aeiia?aei? cia/aiiyi caei?iaeo iaeiie?oe?a
na?aaei? iieacieee ?ioiiaeiaoe?i?a o an?o i?aea?oiao, ye ? ?ai?oa i?e
aiae?c? ?iaeea?aeoaeueiiai ?oiueiai ai?noo a?aei?/aeeny ye aeiaaeee
i?aeaeuaiiy, oae ? cieaeaiiy o ii??aiyii? c a?eiaith ii?iith. A oe?eiio,
ii?iaeuei? iieacieee ?ioiiaeiaoe?i?a on?o aeine?aeaeaieo eean?a i?ney
e?eoaaiiy aeyaeai? o 26 (24,1%) oai?eo, ui i?aeoe/ii ia a?ae??ciy?oueny
a?ae aeaieo, iaea?aeaieo aei e?eoaaiiy (18,6%). Ne?ae a?aecia/eoe, ui
aeine?aeaeaiiy ne?iaaoeiaeo ?ioiiaeiaoe?i?a o oai?eo ia AAe i?ney
e?eoaaiiy aeaco? ia a?aenooi?noue ei?aeyoe?? iaea?aeaieo aeaieo c
ee?i?/ieie ?acoeueoaoaie oa?ai??. Iiaeeeai, a?aenooi?noue iiceoeaii?
aeeiai?ee ai?noo ?ioiiaeiaoe?i?a o i?ioean? e?eoaaiiy na?ae/eoue i?i
?ecee ?aoeeaeea?a AAe.

Iaea?eueoi? ci?ie a i?ioean? oa?ai?? caciaee iieacieee ianiaoeeo?/ii?
?acenoaioiino? i?aai?cio. Niinoa??aaeany oaiaeaioe?y aei ca?eueoaiiy
oaaioeeoa?iiai ?iaeaeno a on?o i?aea?oiao oai?eo, iaeiae o I, III ? V
a?aei?iiino? ?acoeueoao?a aei oa i?ney e?eoaaiiy ia aoee noaoenoe/ii
aeinoia??ieie. Iaea?eueo ni?eyoeeai ia oeae iieaciee aieeioea eiiieaenia
oa?ai?y c aeei?enoaiiyi aaeieaio ? eaoioeoaio: a IV ? VIII i?aea?oiao
?ica?aei?noue cia/aiue aei ? i?ney e?eoaaiiy aoea ia o?eueee
a??ia?aeiith, aea e ia a?ae??ciyeany i?ney e?eoaaiiy a?ae cia/aiue
caei?iaeo ae?oae (a?aeiia?aeii 3,98(0,44 ? 4,23(0,37). Na?aaeiy
aeoeai?noue oaaioeeoico a on?o i?aea?oiao o i?ioean? e?eoaaiiy i?aeoe/ii
ia ci?ieeany, i?ioa i?e aiae?c? ?iaeea?aeoaeueieo cia/aiue aeyaeaia ??
ii?iae?caoe?y o ae?oae c ia?a?nii cieaeaieie iieacieeaie.

Ai?no Oe?E ? cia/aiiy INO-oanoo a on?o i?aea?oiao i?ney e?eoaaiiy
cieceeeny, iaeiae a??ia?aeii a ii??aiyii? c ?acoeueoaoaie aei e?eoaaiiy
eeoa a II, IV, VI, VII ? VIII, oiaoi caeaa?eueoiai c aeeth/aiiyi
aaeieaio. Eiiieaenia oa?ai?y c aeei?enoaiiyi aaeieaio ? eaoioeoaio
ni?eyea iiaeaeueoiio ciaioaiith oeeo iieaciee?a o oai?eo ia AAe aei
?oiueiai ??aiy o caei?iaeo ae?oae. A i?ioean? e?eoaaiiy a?aei?/aii
cieaeaiiy e?eueeino? e?cioeeio ne?iaaoee e?ia? a on?o i?aea?oiao,
i?e/iio aeeth/aiiy aei eiiieaenii? oa?ai?? ye aaeieaio, oae ? eaoioeoaio
i?aeoe/ii ii?iae?coaaei oeae iieaciee.

Oaeei /eiii, a iaio a?eiaeo a?oiao aaeieai aeyaea aieea ia aeaye?
iieacieee ee?oeiiiai ?ioi?oaoo (e?euee?noue eaeeioeeo?a ? e?ioioeeo?a) ?
oaaioeeoa?io ooieoe?th, ni?eya cieaeaiith ai?noo Oe?E, cia/aiiy
INO-oanoo ? ??aiy e?cioeeio. Niieo/aia canoinoaaiiy aaeieaio ?
eaoioeoaio i?eaaei iaeaea aei oe?eeiaeoi? ii?iae?caoe?? caaaeaieo aeua
iieaciee?a ? noi?iaiaeaeoaaeiny iaee?aueie ee?i?/ieie ?acoeueoaoaie.

Iieacieee niaoeeo?/iiai ?ioiieaeeie?co a ?acoeueoao? i?iaaaeaiiai
e?eoaaiiy cieceeeny o an?o oai?eo. O I ? V i?aea?oiao a?aei?/aeiny
ia?aaaaeia ciaioaiiy oa?/iai? nainea?e?caoe??, ui, ai/aaeaeue, coiiaeaia
i?ecia/aiiyi ae??oe c aeeeth/aiiyi ?iaeea?aeoaeueieo i?e/eiii-cia/oueo
aea?aai?a. A i?aea?oiao c aeei?enoaiiyi aaeieaio a?aei?/aii iacia/ia
cieaeaiiy aea?a?? aei an?o aioeaai?a, ui aecia/aeeny, aea caeaa?eueoiai
aei oa?/iaeo. Ie aaaaea?ii, ui oea iiynith?oueny ia eeoa a?iiaea?aaiiith
ae??oith, aea ? i?ioeaea?a?/ieie aeanoeainoyie aaeieaio [Eieanieeiaa
A.A., 1988]. O oai?eo, yeei aei e?eoaaeueiiai eiiieaeno aeeth/aany
eaoioeoai, ciaioeeeny na?aaei? cia/aiiy ?aaeoe?? ?ioiieaeeie?co aei an?o
aioeaai?a, ui, ia iao iiaeyae, iia’ycaia c iaia?aiinoaa?e?coth/ith
ae??th i?aia?aoo, yea i?aeaeuo? ii??a /eiiino? aea?aaio, ui iioeiaeaeo?
iaia?aie eaeeioeeo?a. Iaea?eueo ae?aaeai? iiceoeai? ci?ie niinoa??aaeeny
o oai?eo, ye? iaea?aeoaaee aiaeii/an iaeaeaa i?aia?aoe, ? aeeeeeai?
eiia?iaoe??th iaeiini?yiiaaieo ae?e c ??cieie oi/eaie i?eeeaaeaiiy.

Iieacieee nenoaie IIE i?ney e?eoaaiiy nooo?ai ci?ieeeny a on?o
i?aea?oiao, aea a ??ci?e i???. A?aei?/aia cieaeaiiy ai?noo AeE,
ciaioaiiy ??aiy IAeA, IAA. Aeyaeaia aeoeaaoe?y aioeieneaeaioiiai
caoenoo: i?aeaeuaiiy ??aiy NIAe, aeoeaiino? Ea, ai?noo (-oieioa?iea,
AIA. Iaea?eueo ae?aaeai? oe? ci?ie aoee o oai?eo, ui iaea?aeoaaee
eiiieaenio oa?ai?th c aeei?enoaiiyi eaoioeoaio. A oeeo i?aea?oiao
niinoa??aaeiny c?inoaiiy iieaciee?a oa?iaioaoeaii? eaiee
aioeieneaeaioiiai caoenoo aei cia/aiue, ia?aaaaeath/eo aa?oith iaaeo
a?eiai? ii?ie.

?iaeaen niieo/aiino? ieenethaaeueieo nenoai o i?ioean? oa?ai?? iaa
oaiaeaioe?th aei ciaioaiiy a on?o i?aea?oiao. Iaeiae eeoa i?e
aeei?enoaii? eaoioeoaio a?i iaaeeaeaany aei a?aeiia?aeieo cia/aiue o
caei?iaeo ae?oae, ui na?ae/eei i?i caaeainiaai?noue i?ioean?a IIE ?
aioeieneaeaioiiai caoenoo. Iniaeeai iii?oiith oey iniaeea?noue aoea o
ae?oae ?aiiueiai a?eo, aea o?aaeeoe?eia e?eoaaiiy ni?eyei ciaioaiith
?NIN eeoa aei 1,80(0,19. Aeeth/aiiy aei e?eoaaeueiiai eiiieaeno
eaoioeoaio i?aeoe/ii ii?iae?coaaei oeae ?ioaa?aeueiee iieaciee
(1,13(0,14). Niieo/aia aeei?enoaiiy aaeieaio ? eaoioeoaio i?ecaaei aei
ciaioaiiy ?NIN aei 0,93(0,11 o ?aiiueiio aeeoy/iio a?oe? oa 0,90(0,13 o
iaiiaeyo (o caei?iaeo ae?oae, a?aeiia?aeii, 1,03(0,07 ? 1,01(0,08). Oaea
c?ooaiiy a a?e aeoeaaoe?? aioeieenethaaeueii? nenoaie, i/aaeaeii, ni?ey?
a?eueo noaa?eueiiio noaio i?ioean?a IIE ? i?iyaey?oueny e?aueie
a?aeaeaeaieie ?acoeueoaoaie. A oe?eiio, aea/ai? ?ioiieia?/i? oa
a?io?i?/i? iieacieee a iaea?eueo?e i??? iaaeeceeeny aei a?aeiia?aeieo
ia?aiao??a caei?iaeo ae?oae o i?aea?oiao, ye? iaea?aeoaaee a
eiiieaeniiio e?eoaaii? iaeaeaa i?aia?aoe, ui a?aeiia?aea? iienaiei aeua
ee?i?/iei ?acoeueoaoai ? i?aeoaa?aeaeo? oa?aiaaoe/io aoaeoeai?noue
cai?iiiiiaaiiai iaoiaeo.

Ia i?ioyc? 2-o ?ie?a ?aoeeaeeae aeieeee o 19 (86,4%) oai?eo, ui
iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy, c 22, i?inoaaeaieo eaoaiianoe/ii (8
(80,0%) a?oaeiiai ? 11 (91,7%) ?aiiueiai aeeoy/iai a?eo). Na?aae ae?oae
II ? VI i?aea?oi, aei eiiieaenii? oa?ai?? yeeo aoei aeeth/aii
?ioiiiiaeoeyoi? aaeieai, caaino?aiiy aea?iaoico ca?a?no?iaai? o 14
(66,7%), oiaoi a?aeiia?aeii o 5 (55,5%) oa 9 (69,2%); i?e aeei?enoaii? a
e?eoaaii? eaoioeoaio (III ? VII i?aea?oie) – o 13 (56,5%), oiaoi
a?aeiia?aeii 4 (40,0%) ? 9 (64,3%). A IV ? VIII i?aea?oiao, yeei ii?yae
c o?aaeeoe?eiei e?eoaaiiyi i?ecia/aeeny aiaeii/an aaeieai ? eaoioeoai,
?aoeeaeeae a?aei?/ai? eeoa o 10 (38,5%) oai?eo, 5 (41,7%) a?oaeiiai ? 5
(35,7%) ?aiiueiai aeeoy/iai a?eo, c 26, ca yeeie aaeeny niinoa?aaeaiiy.
C?noaaeaiiy a?aeaeaeaieo ?acoeueoao?a e?eoaaiiy na?ae/eoue i?i
iaea?eueoo aoaeoeai?noue eiiieaenii? oa?ai?? c aeei?enoaiiyi aaeieaio ?
eaoioeoaio. Aiia aeicaieeea cieceoe e?euee?noue ?aoeeaeea?a o oai?eo
iaiiaeyo a 1,9 ?aca, a i?aea?oi? ?aiiueiai aeeoy/iai a?eo a 2,6 ?aca.
I?e/iio a?aei?/aii oaeiae cieaeaiiy oyaeeino? ianooiieo ?aoeeaeea?a (i?e
ii??aiyeueiiio aea/aii? ?iaeaeno SCORAD) a 1,8 ?aca o a?oaeiiio oa 1,5
?aca o ?aiiueiio aeeoy/iio a?oe?.

Oaeei /eiii, canoinoaaiiy ?ioiiiiaeoeyoi?a aaeieaio ?
iaia?aiinoaa?e?caoi?a eaoioeoaio cia/ii i?aeaeuo? aoaeoeai?noue oa?ai??
oai?eo ia AAe iaiiaeyo ? ae?oae ?aiiueiai a?eo, ni?ey? a?eueo no?ee?e
?ai?n?? aea?iaoico oa cieaeaiith oyaeeino? eiai iiaeaeueoeo ?aoeeaeea?a.

AENIIAEE

I?e aoii?/iiio aea?iaoeo? (AAe) o iaiiaeyo oa ae?oae ?aiiueiai a?eo
aeyaeaii e?euee?nia ? ooieoe?iiaeueia i?eai?/aiiy ee?oeiiiai ?ioi?oaoo,
ui ae?aaea?oueny o cieaeaii? ai?noo eaeeioeeo?a ? e?ioioeeo?a, ciaioaii?
A-?icaoeiooai?thth/eo ee?oei, oaio?e?i?acenoaioii? oa oaio?e?i/ooeeai?
noaiiioeyoe?e iaeaea aaea?/? o ii??aiyii? c eiio?ieueiith a?oiith i?e
ii?iaeueiiio ?o ni?aa?aeiioaii?. ??ciini?yiiaai? ci?ie aoii?aeueiiai
?ioi?oaoo i?iyaeythoueny ??cieie aa??aioaie aeen?ioiiaeiaoe?iai??.
A?aei?/athoueny ii?ooaiiy oaaioeeoa?ii? eaiee (cieaeaiiy oaaioeeoa?iiai
?iaeaeno o 1,9 ?aca o a?oaeiiio oa a 2,1 o ?aiiueiio aeeoy/iio a?oe? i?e
i?aeaeuaieo iieacieeao INO-oanoo), c?inoaiiy ai?noo oee?eoethth/eo
?ioiieo eiiieaen?a i?iii?oe?eii o?eaaeino? aea?iaoico ? i?aeaeuaiiy
??aiy e?cioeeio ne?iaaoee e?ia?, ui oa?aeoa?eco? aeoeai?noue caiaeueiiai
i?ioeano.

I?e aea?aieia?/iiio ianoaaeaii? oai?eo ia AAe iaiiaeyo ? ae?oae
?aiiueiai a?eo anoaiiaeaii a?eiao noaae?ei?noue nainea?e?caoe?? oa
?icoe?aiiy niaeo?o i?e/eiii-cia/oueo aea?aai?a ?c ca?eueoaiiyi
o?eaaeino? aea?iaoico. O oai?eo iaiiaeyo c aeaai?noth caoai?thaaiiy aei
8 i?nyoe?a aeyaeaia caeaa?eueoiai ie?aiaaeaioia nainea?e?caoe?y c
ia?aaaaith oa?/iai?. A ?aiiueiio aeeoy/iio a?oe? (i?e a?eueo o?eaaeiio
ia?aa?ao aea?iaoico) aeieea? iie?aaeaioia nainea?e?caoe?y, a oiio /ene?
aaeoa??aeueia, ieeeiaa, ai?aea?iaeueia ? iiaooiaa. ?iaeea?aeoaeuei?noue
niaeo?o i?e/eiii-cia/oueo aea?aai?a o eiie?aoiiai oai?iai ?iaeoue
iaiao?aeiei aea?aieia?/ia ianoaaeaiiy aeey i?ecia/aiiy ae??oe oa
ae?i?iaoe?eieo caoiae?a.

Anoaiiaeaii, ui i?aeaeuaiiy ?ioaineaiino? ia?aeeniiai ieeneaiiy e?i?ae?a
(IIE) o oai?eo ia AAe ae?oae a?oaeiiai ? ?aiiueiai a?eo i?io?ea? ia oii?
cieaeaiiy ooieoe?iiaeueii? aeoeaiino? aioeieneaeaioii? nenoaie
i?aai?cio, a ae?aaeai?noue i?ioean?a e?iiia?ieneaeaoe?? ei?aeth? c?
nooiaiai ineaaeaiiy aioeieenethaaeueiiai caoenoo. I?e oeueiio a?eueo
ae?aaeai? ci?ie niinoa??aathoueny o oa?iaioaoeai?e eaioe?
aioeieneaeaioii? nenoaie. Nooi?iue aeenaaeaino i?i- oa
aioeieenethaaeueieo i?ioean?a caeaaeeoue a?ae o?eaaeino? ia?aa?ao ?
oyaeeino? aea?iaoico.

Cai?iiiiiaaii ?ioi?iaoeaiee iieaciee aaeaino a?eueii?aaeeeaeueii? e
aioeieneaeaioii? nenoai – ?iaeaen Niieo/aiino? Ieenethaaeueieo Nenoai,
ui ?ic?aoiao?oueny ye a?aeiioaiiy noi iieaciee?a i?i- oa
aioeieenethaaeueii? nenoai, ii?iiaaieo aei cia/aiue caei?iaeo ae?oae, ?
iiaea aooe aeei?enoaiee aeey ioe?iee aoaeoeaiino? e?eoaaiiy. Aei a?oie
oai?eo c iaea?eueo cia/ieie ci?iaie oeueiai iieacieea (?NIN>2,0) oa?eoee
caeaa?eueoiai ae?oe ?aiiueiai a?eo (oiaoi c a?eueoith o?eaae?noth
aea?iaoico) ? c a?eueo oyaeeei oe??iei i?ioeanii (?iaeaen SCORAD
38,3(2,4 aaea).

?ic?iaeaiee iaoiae eiiieaeniiai e?eoaaiiy oai?eo ia AAe iaiiaeyo ?
ae?oae ?aiiueiai a?eo c aeei?enoaiiyi ?ioiiiiaeoeyoi?a aaeieaio ?
iaia?aiinoaa?e?caoi?a eaoioeoaio, yeee caaacia/o? ee?i?/ia aeaeoaeaiiy o
89,7% a ii??aiyii? c 37,2% i?e o?aaeeoe?ei?e oa?ai??, cieaeo? /anoioo (a
1,9 ?aca o a?oaeiiio oa 2,6 ?aca o ?aiiueiio aeeoy/iio a?oe?) ?
oyaee?noue (a?aeiia?aeii a 1,8 ? 1,5 ?aca) ianooiieo ?aoeeaeea?a AAe.
Cai?iiiiiaaiee iaoiae ei?eao? ii?ooaiiy ee?oeiiiai ?ioi?oaoo ?
ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio, cnoaa? ni?aa?aeiioaiiy
a?eueii?aaeeeaeueii? e aioeieenethaaeueii? nenoai a a?e aeoeaaoe??
inoaiiuei?, ui ni?ey? a?eueo noaa?eueiiio noaio i?ioean?a IIE.

NIENIE IIOAE?EIAAIEO AAOI?II

I?AOeUe CA OAIITH AeENA?OAOe??

Eaa?eiaiei I.A., Eieanieeiaa A.A., ?iiaiaiei A.I. Eiioiieiae/aneea e
aeea?aieiae/aneea iaoiaeu a aeeaaiinoeea e ioeaiea yooaeoeaiinoe oa?aiee
aoiie/aneiai aea?iaoeoa a ?aiiai aeaoneii aic?anoa // AEo?iae
aea?iaoieiaee e aaia?ieiaee. – 1998. – ? 2. – N. 21-25.

Eaa?eiaiei I.A. Ia?ooaiey eiioiiiai noaoona i?e aoiie/aneii aea?iaoeoa e
eo ei??aeoeey ioa/anoaaiiui oeoii?aia?aoii «Aaeieai» // A?oea
eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu (I?ee.). – 1998. – O. 7, ?
7. – N. 45-49.

Eaa?eiaiei I.A. Ninoiyiea naiaiaeii?aaeeeaeueiie e aioeieeneeoaeueiie
nenoai o aieueiuo aoiie/aneei aea?iaoeoii aeaoae a?oaeiiai e ?aiiaai
aic?anoa // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu (I?ee.). –
1999. – O. 8, ? 1. – N. 54-59.

Ino?ianeee E.I., ?iiaiaiei A.I., Eaa?eiaiei I.A. ?ani?ino?aiaiiinoue
aeea?aicia n?aaee aeaoae oeaio?aeueiiai ?aeiia e?oiiiai i?iiuoeaiiiai
oeaio?a // Aanoiee aeaeaiu e yieaeaieieiaee. – 1999. – O. 3, ? 1. – N.
212-215.

?iiaiaiei A.I., Eieani?eiaa A.A., Eaa?eiaiei I.I. Niin?a ciai?oiueiai
e?eoaaiiy oai?eo ia aoii?/iee aea?iaoeo o noaae?? aeeoy/i? aecaie:
??oaiiy a?ae 07.12.98 i?i aeaea/o iaoaioo ia aeiao?ae, cayaea ? 98052421
a?ae 12.05.98.

Eaa?eiaiei I.A., ?iiaiaiei A.I., Eieanieeiaa A.A. Ninoiyiea
ianiaoeeoe/aneeo oaeoi?ia eiioieoaoa o aieueiuo aoiie/aneei aea?iaoeoii
?aiiaai aeaoneiai aic?anoa // No/ani? i?iaeaie aea?iaoiaaia?ieia??,
einiaoieia?? oa oi?aae?iiy ioi?iiith caei?ia’y: Ca. iaoe. i?aoeue. Aei.
2. – Oa?e?a, 1998. – N. 69-72.

Eaa?eiaiei I.A. ?ieue ia?ooaiee oaaioeeoa?iie nenoaiu a iaoiaaiaca
aoiie/aneiai aea?iaoeoa o aeaoae // Aeooaeuei? ieoaiiy
aea?iaoiaaia?ieia??: Iaoe.-i?aeo. ca. noaoae. Aei. 11. –
Aei?i?iiao?ianuee, 1998. – N. 111-115.

Naia?eia-Eaa?eiaiei I.A. Aoiie/aneee aea?iaoeo (yecaia) o aeaoae //
Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu: Na. noaoae. –
Aeiiaoee, 1997. – N. 92-93.

?iiaiaiei A.I., Naia?eia-Eaa?eiaiei I.A., Eiaia?enoue A.A. Iniaaiiinoe
naineaeeecaoeee e ieuaaui aauanoaai o aeaoae, no?aaeathueo aoiie/aneei
aea?iaoeoii // Aeooaeueiua aii?inu aea?iaoiaaia?ieiaee: Iao/.-i?aeo. na.
noaoae. Aui. 10. – Aeiai?iiao?iane-Oiaeueieoeeee, 1997. – N. 27.

Naia?eia-Eaa?eiaiei I.A., Eiaia?enoue A.A. ?ieue naineaeeecaoeee e
aaeoa?eaeueiui aeea?aaiai a iaoiaaiaca aoiie/aneiai aea?iaoeoa o aeaoae
// Aeooaeueiua aii?inu aea?iaoiaaia?ieiaee: Iao/.-i?aeo. na. noaoae.
Aui. 10. – Aeiai?iiao?iane-Oiaeueieoeeee, 1997.– N. 91.

?iiaiaiei A.I., Eaa?eiaiei I.A. Eecioeei nuai?ioee e?iae o aieueiuo
aoiie/aneei aea?iaoeoii ?aiiaai aeaoneiai aic?anoa // Nia?aiaiiua
aii?inu iaoiaaiaca e oa?aiee ini?eaca e ?ani?ino?ai?iiuo aeea?ae/aneeo
aea?iaoicia: Oac. aeiee. iao/.-i?aeo. eiio. – I., 1998. – N. 94.

Eaa?eiaiei I.I., Eieani?eiaa A.A., ?iiaiaiei A.I. O?oii?aia?ao aaeieai o
eiiieaeniiio e?eoaaii? oai?eo ia aoii?/iee aea?iaoeo // Oac. aeii. VII
Oe?a?inueeiai c’?caeo aea?iaoiaaia?ieia?a. – Ee?a, 1999. – N. 25-26.

AIIOAOe?ss

Eaa?eiaiei I.I. Eiiieaenia ei?eaoth/a oa?ai?y oai?eo ia aoii?/iee
aea?iaoeo iaiiaeyo ? ae?oae ?aiiueiai a?eo c o?aooaaiiyi ci?i ?ioiiiai
noaoono oa nenoaie e?iiia?ieneaeaoe??. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.20 – oe??i? oa aaia?e/i? oai?iae. –
Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo aea?iaoieia?? oa aaia?ieia??,
Oa?e?a, 1999.

Aeena?oaoe?th i?enay/aii aaeineiiaeaiith iaoiae?a e?eoaaiiy aoii?/iiai
aea?iaoeoo o iaiiaeyo ? ae?oae ?aiiueiai a?eo. Anoaiiaeai? iniiai?
caeiiii??iino? ci?i ?ioiiiai noaoono oa nenoaie e?iiia?ieneaeaoe??
oai?eo ia aoii?/iee aea?iaoeo ae?oae aeacaieo a?eiaeo a?oi, aeyaeai?
iaea?eueo ?ioi?iaoeai? iieacieee, ye? oa?aeoa?ecothoue oyaee?noue ?
o?eaae?noue oe??iiai i?ioeano. C o?aooaaiiyi ciaeaeaieo ci?i ?ic?iaeaii
e ai?iaiaaii iaoiae eiiieaeniiai e?eoaaiiy oai?eo ia aoii?/iee aea?iaoeo
?c aeei?enoaiiyi ?ioiiiiaeoeyoi?a aaeieaio oa iaia?aiinoaa?e?caoi?a
eaoioeoaio. I?iaeaiiino?iaaia cia/ia ee?i?/ia aoaeoeai?noue, ca?eueoaiiy
o?eaaeino? ?ai?n?e oa nei?i/aiiy /enea e nooiaiy ae?aaeaiino?
?aoeeaeea?a i?e niieo/aiiio canoinoaaii? aaeieaio oa eaoioeoaio.

Eeth/ia? neiaa: aoii?/iee aea?iaoeo, ae?oe, ?ioiiee noaoon, ia?aeenia
ieeneaiiy e?i?ae?a, aaeieai, eaoioeoai, aoaeoeai?noue oa?ai??.

AIIIOAOeEss

Eaa?eiaiei I.A. Eiiieaeniay ei??eae?othuay oa?aiey aieueiuo aoiie/aneei
aea?iaoeoii aeaoae a?oaeiiai e ?aiiaai aic?anoa n o/aoii eciaiaiee
eiioiiiai noaoona e nenoaiu eeiiia?ieneaeaoeee. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.20 – eiaeiua e aaia?e/aneea aieacie. –
Oe?aeineee iao/ii-enneaaeiaaoaeueneee einoeooo aea?iaoieiaee e
aaia?ieiaee, Oa?ueeia, 1999.

Aeenna?oaoeey inaauaao ia?ooaiey eeaoi/iiai, aoii?aeueiiai eiioieoaoa,
ianiaoeeoe/aneie ?acenoaioiinoe, aeea?ae/aneie ?aaeoeaiinoe,
naiaiaeii?aaeeeaeueiie e aioeieneaeaioiie nenoai o aieueiuo aoiie/aneei
aea?iaoeoii (AAe) aeaoae a?oaeiiai e ?aiiaai aic?anoa e ei??aeoeeth
iaia?oaeaiiuo eciaiaiee a i?ioeanna i?aaeeaaaaiiai eiiieaeniiai ea/aiey
n eniieueciaaieai eiioiiiiaeoeyoi?a aaeieaia, iaia?aiinoaaeeecaoi?a
eaoioeoaia e eo ni/aoaiiiai i?eiaiaiey.

I?e eco/aiee eiioiiiai noaoona enneaaeiaaee ooieoeeiiaeueioth
aeoeaiinoue O-eeioioeeoia e eo noaiiioeyoeee, A-eeioioeeoia iooai
?aaeoeee ?icaoeiia?aciaaiey, niaea?aeaiea eiioiiaeiaoeeiia A, M e G,
oaaioeeoa?ioth aeoeaiinoue iaeo?ioeeia, oaaioeeoa?iue eiaeaen e oano
ainnoaiiaeaiey ieo?ineiaai oao?acieey naiaiaeiui aioo?eeeaoi/iui
eenei?iaeii (INO-oano). Enneaaeiaaee aeoeaiinoue nuai?ioi/iiai eecioeeia
e niaea?aeaiea oee?eoee?othueo eiioiiuo eiiieaenia. Ioeaieaaee ii
?aaeoeee eiioiieaeeieeca noaiaiue naineaeeecaoeee eiioiieiiiaoaioiuo
eeaoie e 27 ieuaaui, auoiaui, yieaea?iaeueiui, iueueoeaaui e
aaeoa?eaeueiui aeea?aaiai.

Eioaineaiinoue i?ioeannia eeiiia?ieneaeaoeee oa?aeoa?eciaaee ii
niaea?aeaieth ia?ae/iiai i?iaeoeoa IIE – aeeaiiauo eiiuthaaoia,
aoi?e/iiai – iaeiiiaiai aeeaeueaeaaeaea e eioaa?aeueiiio iieacaoaeth –
ia?aeeniiio aaiieeco y?eo?ioeeoia. Aeey ioeaiee aioeieneaeaioiie
aeoeaiinoe ii?aaeaeyee o?iaaiue (-oieioa?iea, eae iieacaoaeue
iaoa?iaioaoeaiiai caaia; niaea?aeaiea noia?ieneaeaeeniooacu e
aeoeaiinoue eaoaeacu, oa?aeoa?ecothuea oa?iaioaoeaiia caaii, e iauoth
aioeieeneeoaeueioth aeoeaiinoue ieaciu e?iae – eioaa?aeueiue
iieacaoaeue.

A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee auyaeaii eiee/anoaaiiia e
ooieoeeiiaeueiia oaiaoaiea eeaoi/iiai eiioieoaoa, au?aaeathuaany a
nieaeaiee niaea?aeaiey eaeeioeeoia e eeioioeeoia; oiaiueoaiee eiee/anoaa
A-?icaoeiia?acothueo eeaoie, oaioeeeei?acenoaioiie e
oaioeeeei/oanoaeoaeueiie noaiiioeyoeee ii/oe a 2 ?aca a n?aaiaiee n
eiio?ieueiie a?oiiie i?e ii?iaeueiii eo niioiioaiee. ?aciiiai?aaeaiiua
eciaiaiey aoii?aeueiiai eiioieoaoa i?iyaeyeenue ?acee/iuie aa?eaioaie
aeeneiioiiaeiaoeeiaiee. Ioia/aeenue ia?ooaiey oaaioeeoa?iiai caaia
(nieaeaiea oaaioeeoa?iiai eiaeaena a 1,9 ?aca a a?oaeiii e a 2,1 ?aca a
?aiiai aeaoneii aic?anoa i?e iiauoaiiuo iieacaoaeyo INO-oanoa),
aic?anoaiea niaea?aeaiey oee?eoee?othueo eiioiiuo eiiieaenia
i?iii?oeeiiaeueii aeeeoaeueiinoe aea?iaoica e iiauoaiea o?iaiy eecioeeia
nuai?ioee e?iae, oa?aeoa?ecothuaa aeoeaiinoue ainiaeeoaeueiiai
i?ioeanna.

I?e aeea?aieiae/aneii ianeaaeiaaiee aieueiuo AAe aeaoae a?oaeiiai e
?aiiaai aic?anoa onoaiiaeaia aic?anoiay noaaeeeiinoue naineaeeecaoeee e
?anoe?aiea niaeo?a i?e/eiii-cia/eiuo aeea?aaiia n oaaee/aieai
aeeeoaeueiinoe aea?iaoica. O aieueiuo a?oaeiiai aic?anoa n aeaaiinoueth
caaieaaaiey aei 8 ianyoeaa auyaeaia i?aeiouanoaaiii ieeaiaaeaioiay
naineaeeecaoeey n i?aiaeaaeaieai ieuaaie. A ?aiiai aeaoneii aic?anoa
(i?e aieaa aeeeoaeueiii oa/aiee aea?iaoica) aicieeaao iieeaaeaioiay
naineaeeecaoeey, a oii /enea aaeoa?eaeueiay, iueueoeaaay,
yieaea?iaeueiay e auoiaay. Eiaeeaeaeoaeueiinoue niaeo?a
i?e/eiii-cia/eiuo aeea?aaiia o eiie?aoiiai aieueiiai aeaeaao
iaiaoiaeeiui aeea?aieiae/aneia ianeaaeiaaiea aeey iacia/aiey aeeaou e
yeeieiaoeeiiiuo ia?ii?eyoee.

Onoaiiaeaii, /oi iiauoaiea eioaineaiinoe ia?aeeniiai ieeneaiey eeieaeia
(IIE) o aieueiuo AAe i?ioaeaao ia oiia nieaeaiey ooieoeeiiaeueiie
aeoeaiinoe aioeieneaeaioiie nenoaiu i?aaiecia, a au?aaeaiiinoue
i?ioeannia eeiiia?ieneaeaoeee ei??aee?oao ni noaiaiueth ineaaeaiey
aioeieeneeoaeueiie caueou. I?e yoii aieaa cia/eoaeueiua eciaiaiey
iaaethaeathony a oa?iaioaoeaiii caaia aioeieneaeaioiie nenoaiu. Noaiaiue
aeenaaeaina i?i- e aioeieeneeoaeueiuo i?ioeannia caaeneo io
aeeeoaeueiinoe oa/aiey e oyaeanoe aea?iaoica.

?ac?aaioai iaoiae eiiieaeniiai ea/aiey aieueiuo AAe n eniieueciaaieai
eiioiiiiaeoeyoi?a aaeieaia e iaia?aiinoaaeeecaoi?a eaoioeoaia.
I?aaeeiaeaiiue iaoiae ei??eae?oao ia?ooaiey eeaoi/iiai eiioieoaoa e
ianiaoeeoe/aneie ?acenoaioiinoe i?aaiecia, naeaeaaao niioiioaiea
naiaiaeii?aaeeeaeueiie e aioeieeneeoaeueiie nenoai a noi?iio aeoeaaoeee
iineaaeiae, /oi niinianoaoao aieaa noaaeeueiiio ninoiyieth i?ioeannia
IIE, iaania/eaay oai naiui iieiaeeoaeueiue eeeie/aneee yooaeo.
Eiiieaeniia ea/aiea n eniieueciaaieai aaeieaia e eaoioeoaia iioeiece?oao
aeeaeaeoea eeeie/aneea ?acoeueoaou, nieaeaao /anoioo (a 1,9 ?aca a
a?oaeiii e a 2,6 ?aca a ?aiiai aeaoneii aic?anoa) e oyaeanoue
(niioaaonoaaiii a 1,8 e 1,5 ?aca) iineaaeothueo ?aoeeaeeaia AAe.

Eeth/aaua neiaa: aoiie/aneee aea?iaoeo, aeaoe, eiioiiue noaoon,
ia?aeeniia ieeneaiea eeieaeia, aaeieai, eaoioeoai, yooaeoeaiinoue
oa?aiee.

ABSTRACT

Lavrinenko O.A. The integrated corrective therapy of newborns and early
age children with atopic dermatitis considerated the disturbances of
immune status and lypoperoxidation system. – Manuscript.

Thesis for the degree of candidate of medical sciences by speciality
14.01.20 – skin and venereal diseases. – The Ukrainian
Scientific-Research Institute of the Dermatology and Venerology,
Kharkov, 1999.

The dissertation is devoted to improvement of therapy methods at
newborns and early age children with atopic dermatitis. There is
established the basic laws of immune status and system lypoperoxidation
changes at specified age children with atopic dermatitis. The most
informative parameters describing weight and duration of skin process
are revealed. In view of the founded changes there are developed and
aprobated a method of complex treatment of the atopic dermatitis using
immunomodulator bacplan and membranostabilisator ketotifen. The
expressed clinical efficiency, increase of remission duration, both
reduction of number and degree of relapses at joint application of
bacplan and ketotifen is shown.

Key words: atopic dermatitis, children, immune status, lipid
peroxidation, bacplan, ketotifen, treatment efficiency.

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