2

EOAAINUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

I?OEOIAE IEUeAA ?AAI?AIA

OAeE 616.36: 615.322: 622.012. 2-057. 2

EE?I?EI-IAOIAAIAOE*I? INIAEEAINO? ?ICAEOEO CAOAI?THAAIUe IA*?IEE

O A??IEE?A AEEAIEEO AOA?EUeIEO OAOO

AeIIAANO ? OEssOE ?OIUeI? I?IO?EAEOEEE

14.01. 02 — aioo??oi? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Eoaainuee — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe,

caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie

i?ioani? IEIOE?I Aieiaeeie? sseiae/

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoth/ee eaoaae?ith oa?ai?? oaeoeueoaoa i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

OA?*AIEI Iaoae?y Ay/aneaa?aia

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?

ina?oe ?i. I.E. Ooi?ea, caa. eaoaae?ith aano?i-

aioa?ieia?? ? ae??oioa?ai??

aeieoi? iaaee/ieo iaoe, i?ioani?

IOO?IOeAA Aieiaeeie? Aiaoiae/

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoth/ee eaoaae?ith aini?oaeueii? oa?ai?? ?2

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey IIC Oe?a?ie, eaoaae?a aini?oaeueii? oa?ai?? ?2

Caoeno a?aeaoaeaoueny “29” aeiaoiy 1999?. i 8ii aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 29.600.01 i?e Eoaainueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? IIC Oe?a?ie (348045, i. Eoaainuee, ea.50-??//y
Iai?iie Eoaainueea, 1. Oaeaoii: 54-85-57).

C aeena?oaoe??th iiaeia iciaeiieoeny o iaoeia?e a?ae?ioaoe?
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (348045, i. Eoaainuee,
ea.50-??//y Iai?iie Eoaainueea, 1).

Aaoi?aoa?ao ?ic?neaiee “29 aa?aniy” 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani? ______________ A.?. Eieii??oeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie Aieea ia i?aai?ci a??iee?a eiiieaeno oe?aeeeaeo
oaeoi??a ae?iaieoeoaa: aaaeeee o?ce/iee o?oae, iaa??aath/ee i?e?iee?iao,
caieeaii?noue iia?o?y, ?ioaineaiee ooi, a?a?aoe?y, i?aeaeuaiee
aa?iiao?e/iee oene, aieea o?i?/ieo ?a/iaei, a?iien?y oa i?aeaeuaiiy
?aae?aoe?eiiai oiio aeceaathoue ci?ie o ooieoe?iioaaii? ?yaeo nenoai oa
i?aai?a c iine?aeoth/ei ?icaeoeii a ieo iaoieia?/ieo ci?i. C oeei
iia`ycaii ca?eueoaiiy caoai?thaaiino? oaooa??a ? cieaeaiiy o?eaaeino?
aeeooy. A caaaeuei?e no?oeoo?? caoai?thaaiino? cia/io a?oio caeiathoue
oai?iae ia/?iee oa aeia/iaea?aeieo oeyo?a. Ii?yae c o?ii?/ieie a??onieie
aaiaoeoaie cia/io ?ieue a?athoue caoai?thaaiiy ia/?iee ci?oaii?
ao?ieia?? (I.ss.Aaaae, 1998; I.A.Oa?/aiei, 1996,1998). I?ioa o ca`ceo c
oei, ui aeacai? caoai?thaaiiy ia yaeythoueny i?ioan?eieie, aea/aiith
oaeoi??a, ye? ni?eythoue ?o ?icaeoeo, a oaeiae ?ic?iaoe? i?io?eaeoe/ieo
caoiae?a, i?eae?ey?oueny iaaeinoaoiuei oaaae.

Caaaeyee oeueiio oeyoe cieaeaiiy caoai?thaaiino? oa ci?oeiaiiy caei?ia`y
oaooa??a ? aaaeeeaei caaaeaiiyi, yea noi?oue ia?aae iaaee/iith iaoeith
Aeiiaano.

Aaaeeee o?ce/iee o?oae a oiiaao iaa??aath/iai i?e?iee?iaoo aeeaieeo
aoa?eueieo oaoo iiaea i?ecaiaeeoe aei ?icaeoeo ino?iai oa o?ii?/iiai
ia?aa??ao ?ia?oiee?a (A.ss.Ieioe?i, TH.A. Ao?iae, 1996; A.N. Ia?aaea??e,
1996 ), c?inoo /enea ??cieo caoai?thaaiue aioo??oi?o i?aai?a (A.I
Aaeooe?ia ? ni?aaao., 1996; A.I.Eiaaoeue 1992) ? ,a oiio /ene?,
caoai?thaaiue ia/?iee (A.A.Eaeueyiia, 1993; A.A. *??e?i, A.?. Iei?ieia,
1994 ).

Anoaiiaeaii, ui ia/?iea ? iaea?eueo /ooeeaith aei aieeao iaa??aath/iai
i?e?iee?iaoo (O.A.Iaaeiaa, 1995) oa o?i?/ieo ?a/iaei (A.I.O?ieia ?
ni?aaao., 1994), aaaa yeeo iineeth?oueny i?e ii?aeiaii? c aeeiiaiiyi
aaaeeeo ?ia?o, i?aeaeuaiei aa?iiao?e/iei oeneii oa ?ioeie oaeoi?aie
i?aecaiiiai na?aaeiaeua. I?e oeueiio a?aecia/aii, ui i?e ia?aa??aaii?
aeieeathoue ooieoe?iiaeuei? (O.E.Naiaii?eiaa ? ni?aaao., 1992) oa
no?oeoo?i? ci?ie ia/?iee (A.A. Ia?aaea??e ? ni?aaao., 1993).

Aaaeeeaa ?ieue o iaoiaaiac? ?yaeo caoai?thaaiue a?aeaiaeeoueny
?ioiieia?/i?e iaaeinoaoiino? (A.I. O?ieia ? ni?aaao., 1993). Ii?yae c
oeei ?ioiia iaaeinoaoi?noue iiaea aeieeaoe o a??iee?a aeeaiei?
aoa?eueii? oaooe i?e aieea? oe?aeeeaeo oaeoi??a i?aecaiiiai na?aaeiaeua
( TH.?. Eoiae??a ? ni?aaao., 1993; N.Oo?euaa, 1997; A.O. *a?iooaiei,
1992).

Ne?ae i?aee?aneeoe, ui a inoaii? ?iee i?aeoe/ii a?aenooi? ?iaioe, ye?
i?enay/ai? iaoai?ciai ?icaeoeo ?ioiiaeao?oeeoiiai noaio oaooa??a. Na?aae
?aaoethth/eo oaeoi??a ?ioi?oaoo aaaeeeaa i?noea caeia? ai?iii oeiono
1-oeiicei (A.A. ss??e?i, ?.I. A?eyeia, 1996).

Iaiao?aeii a?aei?oeoe, ui aei e?ioey ia ae??oai? iaoiaaiaoe/i?
iniaeeaino? oaieiaiai iioeiaeaeaiiy ia/?iee.

Aeyaeaiiy ?aii?o ii?ooaiue no?oeoo?iiai oa ooieoe?iiaeueiiai noaio
ia/?iee oa aea/aiiy oaeoi??a, ye? ni?eythoue ?o ?icaeoeo, iiaea
aeicaieeoe ?ic?iaeoe iaoiaee ?aiiuei? i?io?eaeoeee, e?eoaaiiy oa
?aaa?e?oaoe?? caoai?thaaiue ia/?iee o a??iee?a.

I?ioa ?ia?o, i?enay/aieo eiiieaeniiio aeine?aeaeaiith ?aii?o ii?ooaiue
ooieoe?iiaeueiiai noaio ia/?iee, iaoai?ciai iioeiaeaeoth/iai aieeao
ia?aa??ao ia ?ioiio nenoaio, ye? aeeth/athoue aea/aiiy ai?iiio oeiono
1-oeiiceio, o i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a oa oai?eo ia
o?ii?/iee aaiaoeo aeeaieeo aoa?eueieo oaoo, a aeinooii?e e?oa?aoo?? ia
ciaeaeaii.

Ca`ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie ? oaiaie Aeaia
aeine?aeaeaiiy i?iaiaeeeinue a ieai? iaoeiaeo ?ia?o Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, ia eaoaae?? aioo??oi?o oai?ia
oaeoeueoaoo i?neyaeeieiiii? ina?oe ? ? o?aaiaioii IAe? “Aea/eoe
caoai?thaaii?noue a??iee?a aeeaieeo aoa?eueieo oaoo a?ia?oii?/iith
oai?iaith, ?oai?/iith oai?iaith na?oey, oai?iaaie ie?ie, ia/?iee ?
na/iaea?aeieo oeyo?a oa ?ic?iaeoe e?eoaaeueii-i?io?eaeoe/i? oa
?aaa?e?oaoe?ei? i??ii?e?inoaa” (? aea?aeaaii? ?a?no?aoe??-
?01890069866).

Iaoith aeine?aeaeaiiy aoei aeyaeaiiy ?aii?o ee?i?ei-eaai?aoi?ieo
e?eoa???a oa aea/aiiy ie?aieo iaoai?ci?a ?icaeoeo caoai?thaaiue ia/?iee
o a??iee?a aeeaiei? aoa?eueii? oaooe oa ?ic?iaea caniaa ?o i?io?eaeoeee.

Aeey aeinyaiaiiy iinoaaeaii? iaoe iaiao?aeii aoei ae??oeoe ne?aeoth/?
caaaeaiiy :

1. Aea/eoe caoai?thaai?noue i?aai?a aaiaoia?e?a?ii? nenoaie o a??iee?a
aeeaiei? aoa?eueii? oaooe.

2. Aea/eoe ooieoe?iiaeueiee noai ia/?iee a??iee?a ia iniia?
aeine?aeaeaiiy a?io?i?/ieo iieaciee?a caeaaeii a?ae aaaeeino?
aeeiioth/eo ?ia?o, a?eo oa noaaeo ?iaioe a i?aecaiieo oiiaao.

3. Aea/eoe noai ?ioiiiai noaoono o i?aecaiieo a??iee?a aeeaieeo
aoa?eueieo oaoo, c`ynoaaoe iayai?noue ci?i caeaaeii a?ae aaaeeino?
aeeiioth/eo ?ia?o, a?eo oa noaaeo ?iaioe a i?aecaiieo oiiaao.

4. Anoaiiaeoe ci?io eiioeaio?aoe?? ai?iiio oeiono 1-oeiiceio, aieea ia
eiai ??aaiue aaaeeino? aeeiioth/eo ?ia?o, a?eo oa noaaeo ?iaioe a
i?aecaiieo oiiaao oa anoaiiaeoe eiai aca?iica`ycie c iniiaieie
ia?aiao?aie ?ioiia?aie.

5. Aecia/eoe ?ieue iaa??aath/iai i?e?iee?iaoo a ?icaeoeo ii?oieia?/ieo
ci?i oa ii?ooaiue ooieoe?iiaeueiiai noaio ia/?iee
(ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy).

6. ?ic?iaeoe oa i?iaanoe ai?iaaoe?th iaoiaea ?aiiuei? i?io?eaeoeee
caoai?thaaiue ia/?iee o i?aecaiieo a??iee?a aeeaiei? aoa?eueii? oaooe.

Iaoeiaa iiaecia ?iaioe Aia?oa aeyaeai? ii?ooaiiy ooieoe?? ia/?iee
a??iee?a, ye? ae?aaeathoueny o cieaeaii? ci?noo aeueaoi?i?a a ne?iaaooe?
e?ia?, iniaeeai cia/i? o iieiaeeo a??iee?a oa oaooa??a c i?aecaiiei
noaaeai aei 5 ?ie?a; a?aeiini?i i?aeaeuaiiyi ??aiae o?ainai?iac, ??aiy
oieanoa?eio oa -e?iii?ioa?ae?a o ne?iaaooe? e?ia?, ia?aaaaeii o
?ia?oiee?a iniiaieo i?ioan?e, aeeiioth/eo aaaee? ?iaioe a iani?eyoeeaeo
oiiaao a??ieo ae?iaie.

Aia?oa aeyaeaii cia/ia cieaeaiiy ??aith ai?iiio oeiono 1-oeiiceio o
a??iee?a aeeaieeo aoa?eueieo oaoo.

Aia?oa anoaiiaeaii, ui o a??iee?a ai?iii oeiono 1-oeiicei i?eeia?
o/anoue o ?aaoeyoe?? ?ioiiiai noaoono.

Anoaiiaeaiee ei?aeyoe?eiee ca`ycie 1-oeiiceio c iniiaieie ia?aiao?aie
?ioiia?aie oaooa??a.

?ic?iaeaii oa ai?iaiaaii iiaee iaoiae ?aiiuei? i?io?eaeoeee
caoai?thaaiue ia/?iee o a??iee?a.

I?aeoe/ia cia/ou?noue io?eiaieo ?acoeueoao?a ?acoeueoaoe aeine?aeaeaiiy
aeathoue iiaeeea?noue oe?iei aeei?enoiaoaaoe o i?aeoe/i?e ?iaio?
e?eoaaeueieo caeeaae?a ei?aeoe?th ?ioiiiai noaoono oa ??aith ai?iiio
oeiona 1 –oeiiceia aeey i?io?eaeoeee caoai?thaaiue ia/?iee o i?aecaiieo
a??iee?a aeeaieeo aoa?eueieo oaoo.

Iaea?aeai? aeai? /?oei aeacothoue ia iaiao?aei?noue aaaaeaiiy cacia/aieo
ooieoe?iiaeueieo iieaciee?a ia/?iee a iaia`yceiaee ia?ae?e
aeine?aeaeaiue i?e i?iaaaeaii? ia??iaee/ieo i?io?eaeoe/ieo iaeyae?a o
?ia?oiee?a iniiaieo i?ioan?e aeeaieeo aoa?eueieo oaoo.

I?iaiaeeoe ui??/i? aeine?aeaeaiiy o in?a, a?aeianaieo aei a?oi ?eceeo,
noaio ?ioiii? nenoaie oa ??aith ai?iiia 1-oeiiceia aeey aeyaeaiiy
?ioiiaeao?oeeoiiai noaiiaeua c iaoith nai?/anii? ei?aeoe??.

Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeai? a i?aeoe/io
?iaioo Eoaainueei? iaeanii? ee?i?/ii? e?ea?i?, iaaeeei-nai?oa?ieo /anoei
i?no Ia?aiiaenueea, Aao?ooaai, Ae/aanueea, Naa?aeeiaee oa ?iaaiueee.

Iaea?aeai? aeai? aeei?enoiaothoueny a eaeoe?eiiio eo?n? aeey nooaeaio?a,
e?ea??a-?ioa?i?a oa e?ea??a-neooa/?a oaeoeueoaoo i?neyaeeieiiii? ina?oe
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, eaoaae?ao aioo??oi?o
oai?ia Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, Oe?a?inueei?
iaaee/ii? noiiaoieia?/ii? aeaaeai?? (Iieoaaa).

Iniaenoee aianie caeiaoaa/a Aeena?oaioii naiino?eii i?iaiaeeany iaeyae
a??iee?a oa aiae?c iaaee/ii? aeieoiaioaoe?? c iaoith i?aeai?o
eiioeiaaioo aeey iiaeeaeaiiai aeine?aeaeaiiy, caa?? e?ia? oa cacia/aiiy
??aith 1-oeiiceio. Aaoi? i?eeiaa o/anoue a i?iaaaeaii? ii?oieia?/iiai,
?ioiieia?/iiai oa a?io?i?/iiai aeine?aeaeaiue, naiino?eii aoa
i?iaaaeaiee aiae?c iaea?aeaieo ?acoeueoao?a ii eiii`thoa?i?e i?ia?ai?,
yeo a?i naiino?eii aaeaiooaaa aeey i?iaaaeaiiy aeaii? ?iaioe.
Caeiaoaa/ai naiino?eii i?iaaaeaiee aea?? i?aia?aoo aeey ei?aeoe??
aeyaeaieo ci?i oa ?ic?iaeaia noaia eiai canoinoaaiiy.

Ai?iaaoe?y ?iaioe Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ia
?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeinyaiaiiy oa
iaae??oaii? ieoaiiy aano?iaioa?ieia??” (Oa?e?a. 1998), ? iaoe?iiaeueiiio
eiia?an? Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??
(Aeoooa, E?ei, 1998), XIV c`?cae? oa?aiaao?a Oe?a?ie (Ee?a, 1998).

No?oeoo?a oa ianya aeena?oaoe?? Aeena?oaoe?y aeeeaaeaia ia 141
noi??ieao, aeeth/ath/e anooi, iaeyae e?oa?aoo?e, /ioe?e aeaae aeanieo
aeine?aeaeaiue, iaaiai?aiiy, aeniiaee, nienie aeei?enoiaaieo aeaea?ae oa
i?iiiceoe?e. Aeena?oaoe?y i?noeoue 13 oaaeeoeue oa 32 iaethiea. Nienie
aeei?enoaieo aeaea?ae neeaaea? 154 a?o/eciyieo ? 42 ?iicaiieo
e?oa?aoo?ieo iineeaiue.

Ioae?eaoe?? Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 14 ?ia?o, a oiio
/ene? 7 noaoae a oaoiaeo aeaeaiiyo ? 2 iniaenoeo noaoo?. Ioi?ieai? oa
io?eiai? cana?ae/aiiy ia 3 ?aoe?iiae?caoi?nuee? i?iiiceoe??.
Cai?iiiiiaaii can?a i?io?eaeoeee ?ioiiaeao?oeeoiiai noaio o a??iee?a
aeeaieeo aoa?eueieo oaoo (Iaoaio Oe?a?ie ?21063 A a?ae 04.11.97 ?.).

INIIAIEE CI?NO

Iaoa??aee ? iaoiaee aeine?aeaeaiiy Ia oaoo? “Ieeaii?” AeOE
“Eoaainueeaoa?eey” aoei i?iaaaeaii eiiieaenia aeine?aeaeaiiy 850
a??iee?a, c ieo a?ae?a?aii 77 i?aeoe/ii caei?iaeo i?aecaiieo ?iai/eo.
A?ae?a?ai? ?ia?oieee ia ceiaaeeaaee aeeiaieue ca?aeii aeaieo
aeeniaina?iiai iaeyaeo, aieaooaaiiy oa a?aenooiino? ?a?no?aoe?? a
ia?eieia?/iiio aeeniaina??. C ieo ?ia?oieee “iniiaieo” oaooa?nueeeo
i?ioan?e (A?IC, i?io?aeieee), aeeiioth/e aaaee? ?iaioe a iaea?eueo
iani?eyoeeaeo oiiaao i?aecaiiiai i?e?iee?iaoo, neeaee 34 /ieia?ea.

O an?o ?ia?oiee?a aoei i?iaaaeaii aeine?aeaeaiiy a?e??oa?io, caaaeueiiai
a?eeo, aeueaoi?i?a, aeiaoe?i?a, oieanoa?eio, -e?iii?ioa?ae?a, o?iieiai?
i?iae, aeai?iiai? ai?iio?ainoa?ace (AeAO) oa ania?aa?iiai?
ai?iio?ainoa?ace (AnAO) o ieaci? e?ia?, ia?ea??a a??oniiai aaiaoeoo ca
caaaeueiii?eeiyoeie iaoiaeeeaie (A.A.Ia?aaea??e, TH.?. Oiaeaanueeie,
1993). I?e aiae?c? iaea?aeaieo iieaciee?a ia/enethaaany eiao?oe??io aea
??o?no (AnAO/AeAO) (N.Ae. Iiaeeiiaa, 1998).

Aeey aecia/aiiy aieeao ?iaioe a??iee?a a i?aecaiieo oiiaao ia aea/a?i?
iieacieee ?ia?oieee aoee ?icae?eai? ia a?oie: ? – on? ianoaaeaii?
a??iee? (77 /ie.). C ieo iniae, ui aeeiiothoue aaaeeo o?ce/io ?iaioo a
iaea?eueo iani?eyoeeaeo oiiaao i?aecaiieo ae?iaie neeaee 34 /ie. ? aoee
a?aeianai? aei ?? a?oie; ??? a?oia – iniae, ui aeeiiothoue ?iaioe
na?aaeiuei? aaaeeino? a i?aecaiieo oiiaao (43 /ie.). Eiio?ieueio a?oio
neeaee 20 /ieia?e.

Aeey anoaiiaeaiiy aieeao a?eo oa noaaeo ?iaioe a i?aecaiieo oiiaao ia
aea/a?i? iieacieee on? ianoaaeai? aoee ?icae?eaii? ca a?eii ia oae?
a?oie : 20-30 ?ie?a (13 /ie.); 31-40 ?ie?a (39 /ie.); 41-50 ?ie?a (14
/ie.) oa 51-60 ?ie?a 911 /ie.); oa ca noaaeai: aei 5 ?ie?a (6 /ie.);
5-10 ?ie?a (17 /ie.); 11-15 ?ie?a (25 /ie.);16-20 ?ie?a (13 /ie.), 21-25
?ie?a (16 /ie.).

I?e aeine?aeaeaii? ee?oeiii? oa aoii?aeueii? eaiie ?ioi?oaoo a??iee?a
cacia/aany ci?no e?ioioeeo?a (E) a ia?aoa??/i?e e?ia? (Boyum A., 1986).
Cacia/aiiy O-e?ioioeeo?a, noaiiioeyoe?e O-oaeia??a / ?iaeoeoi??a oa
O-noi?ani??a /e?ea??a, iaoo?aeueieo e?ea??a, A-e?ioioeeo?a canoinoaaeiny
c aeei?enoaiiyi iaiae? iiiieeiiaeueieo aioeo?e CD3, CD4, CD8, CD22 (Orho
Diagnostic Systems Inc., NOA)(A.I.O?ieia ? ni?aaao., 1989). Iae?/oaaee
?aaeoe?th a eai??? Ai?y?aa i?ae na?oeiaei i?e?ineiiii. ?ioiiaeiaoe?ie
ne?iaaoee e?ia? eeania A, M, G cacia/aee iaoiaeii ?aae?aeueii?
?ioiiae?ooc?? (Mancini G., 1965). Cacia/aiiy ??aith Oe?E i?iaiaeeeeny
iaoiaeii Eao?? c iine?aeoth/ei ia?ae?eii a aeine?aeaeo?i?e ne?iaaooe?;
?acoeueoao ae?aaeaee a oiiaieo iaeeieoeyo (Haskova V., 1977).

Aecia/aiiy ci?noo a ne?iaaooe? e?ia? 1-oeiiceia canoinoaaeiny
?aae?i?ioiieia?/iei iaoiaeii a eaai?aoi??? ?ioiia?ioaoiieia?? IAe?
oaoiieia?? e?iaicai?ithaa/ae oa ai?iiiaeueieo i?aia?ao?a, i. Iineaa
(caa. eaai?aoi???th e.a.i. A.I.Oin?ae).

Aeey aea/aiiy aieeao oaiea ia no?oeoo?o ia/?iee aoei cae?eniaii
aenia?eiaioaeueia aeine?aeaeaiiy 75 a?eeo iaoethe?a, yeeo ?ici?uoaaee a
oaieia?e eaia?? c oaiia?aoo?ith iia?o?y 45iN oa a?aeiiniith aieia?noth
65%. Eiio?ieueio a?oio neeaee 10 ?ioaeoieo oaa?ei.

On? oaa?eie ?ici?uoaaeenue a eaia?? iaeiiiiiaioii oa caaeaaeeny o /ania?
oi/ee, a?aeiia?aeii noaae?yi: ?ooiaiai caoaeaeaiiy (?C), oaieiaiai
oaea?o (OO) oa e?ioeaai? noaae?? oaieiaiai oaea?o – aaii?? (Aa), ui
niinoa??aaeiny /a?ac 2 aiaeeie 25±5 oaee., 3 aiaeeie 25±5 oaee. oa 4
aiaeeie 25±5 oaee. a?ae ii/aoeo aenia?eiaioo a?aeiia?aeii. E??i
iaeiie?aoiiai ia?aa??ao i?iaiaeeeiny o?ii?/ia ia?aa??aaiiy oaa?ei aei
noaae?? ?C uiaeaiii i?ioyaii 7 aei?a.

Aeey ii?oieia?/iiai aeine?aeaeaiiy oaa?ei caaeaaee oeyoii aeaeai?oaoe??
ia oii? ao??iiai ia?eico. Oeaieio ia/?iee i?aeaeaaaee
aeaeo?iiii-i?e?ineii?/iiio, aeaeo?iiiia?noio?i?/iiio aeine?aeaeaiith
(JEM – 7A, ssiii?y) oa na?oeia?e i?e?ineii??. E?euee?nia ii?oiiao??y
canoiniaoaaeany ca aeiiiiiaith n?oee A.A.Aaoaiae?eiaa.

E?ea?nueeee can?a “Ni??oe?ia” i?eeiaany 20 ?ia?oieeaie ii 2 oaaeaoee
(1a) o?e ?ace ia aeaiue i?ioyaii 7-10 aei?a (iiia? ?a?no?aoe?eiiai
iina?ae/aiiy 3770).

Iaea?aeai? aeai? ia?iaethaaeenue ca aeiiiiiaith niaoe?aeueiiai iaeaoo
i?eeeaaeieo i?ia?ai ia AII ?AI ?N-486 AO, neeaaeaieo ia iia? Foxpro. I?e
oeueiio cacia/aeenue na?aaei? aaee/eie, ?o iiieeea, e?eoa??e
aeinoia??iino? ca aeiiiiiaith t-Nouethaeaioa oa eiao?oe??ioo ei?aeyoe??
r.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Caoai?thaai?noue oai?iaaie
ia/?iee oa aeia/iaea?aeieo oeyo?a ia oaoo? “Ieeaii?” i?aeaeuoaaeany c
1993 ii 1996 ??e. Aei oiai ae, o 1996 ?ioe? a?aeaoeiny iaea?eueoa
ca?eueoaiiy iieaciee?a: a aeiaaeeao ia 1,3 (92,8%; ?ioaineaiee iieaciee
caoai?thaaiino?– ?.i. ia 1000 ?ia?oiee?a) oa a aeiyo iai?aoeacaeaoiino?
ia 38,2 (100,3%) i?e oeueiio, caoai?thaai?noue neeaea 34 aeiaaeea oa 948
aei?a oei/aniai? ao?aoe i?aoeacaeaoiino?, oa aoea naiith aenieith a
aoa?eueiicaeiaoaath/?e aaeoc? Oe?a?ie, oa iaeaea aaea?/? ia?aa?eueooaaea
na?aaei? iieacieee a Eoaainuee?e iaeano?.

I?ney eiiieaeniiai i?io?eaeoe/iiai iaeyaeo 850 a??iee?a aeey oe???
?iaioe aoee a?ae?a?ai? 77 i?aeoe/ii caei?iaeo oaooa??a.

?acoeueoaoe aiae?co nea?a a??iee?a iieacaee, ui iaea?eueo
?iciianthaeaeaieie na?aae a??iee?a aoee: anoaiiaaaaoaoeaiee n?iae?ii
(3,2%), aeeniaine/iee n?iae?ii (2,9%), nea?ae ia aaaee?noue oa aie? a
i?aaiio i?ae?aaa?`? (1,8%), aie? a noaeiaao (1,2%). I?e oeueiio, o 21,5%
a??iee?a ca aeaieie oeueo?acaoeiaiai aeine?aeaeaiiy aecia/ai?
??ciiiai?oi? ci?ie (ca?eueoaiiy, aeaoi?iaoe?y oa ooieu?iiy no?iie
aeia/iiai i?oo?a; i?enooi?noue a?ia?aoiaaiii? aca?n? oa inaaeeo a
ii?iaeiei? aeia/iiai i?oo?a, ca?eueoaiiy ?ici???a, aeeoocia ca?eueoaiiy
aoiaaiiino? oa iaiaeii?iaeiino? ia?aio?ie ia/?iee).

O an?o ianoaaeaieo ia?ea??a a??oniiai aaiaoeoo cacia/aii ia aoei.

Aeey ooi/iaiiy oa?aeoa?o aeyaeaieo ooieoe?iiaeueieo ci?i ia/?iee aoei
cae?eniaii a?io?i?/ia aeine?aeaeaiiy e?ia? a??iee?a.

Iaea?aeai? iieacieee aiae?coaaeenue caeaaeii a?ae aaaeeino? ?ia?o, a?eo
oa noaaeo a??iee?a. I?e oeueiio anoaiiaeaii, ui caaaeueiee a?eie a e?ia?
a??iee?a neeaa 68,69 – 73,0 a/e. I?e ii??aiyii? c eiio?ieueiith a?oiith
(74,6±2,8 a/e) o ?ia?oiee?a ?? a?oie, aeeiioth/eo aaaee? ?iaioe a
iaea?eueo iani?eyoeeaeo i?e?iee?iaoe/ieo oiiaao, anoaiiaeaii cieaeaiiy
(?<0.05) caaaeueiiai a?eeo a e?ia?. I?e oeueiio caaaeueiee a?eie o oaooa??a ?? a?oie aoa ieae/a, i?ae o a??iee?a ??? a?oie (?<0.05). Ci?no aeueaoi?i?a o ?ia?oiee?a on?o a?oi aoa ieae/a, i?ae o eiio?ieuei?e a?oi? (?<0.05). I?e oeueiio iaea?eueo iecueeee ??aaiue aeueaoi?i?a a e?ia? (37,16±1,8%) a?aecia/aiee o ?ia?oiee?a ?? a?oie. A?aeiioaiiy aeueaoi?i?a oa aeiaoeei?a (A/A) o ?ia?oiee?a on?o a?oi ciaoiaeeeinue a iaae? a?ae 0,59±0,14 aei 0,69±0,11 oa aoei cia/ii ieae/a iieaciee?a eiio?ieueii? a?oie (?<0.05). Anoaiiaeaia o oaooa??a a?iiaeueaoi?iai?y iiaea aooe ca`ycaia c aaaeeith o?ce/iith i?aoeath a oiiaao a?ia?oa?i??, ye? aeceaathoue aaeeea niiaeeaaiiy a?eeo neaeaoiith ioneoeaoo?ith, aai ii?ooaiiyi aeueaoi?ineioacoth/i? ooieoe?? ia/?iee. ??aaiue oieanoa?eio a ne?iaaooe? e?ia? o ?iai/?o ? oa ?? a?oi ia?aa?eueooaaa eiio?ieuei? iieacieee (?<0.05). Ci?no -e?iii?ioa?ae?a a ne?iaaooe? e?ia? ?iai/eo ?? a?oie aeyaeany aeua aeaieo eiio?ieueii? a?oie (?<0.05). A?aei?/ai? ii?ooaiiy e?i?aeiiai iai?io iaea?eueo ae?aaeai? o ?iai/eo, ui aeeiiothoue aaaee? ?iaioe a iaeiani?eyoeea?oeo i?e?iee?iaoe/ieo oiiaao, iaaooue, c`yaeyeenue iane?aeeii aieeao aaaeei? o?ce/ii? i?aoe?. Iaeiae, ci?ie e?i?aeiiai iai?io iiaee aooe aoi?eiieie /a?ac a?iiaeueaoi?iai?th. E??i oiai, anoaiiaeai? o oaooa??a ci?ie e?i?aeiiai iai?io iiaee ?icaeoeny i?e ii?acoe? ia/?iee, aecaaii? ia?aa??aaiiyi Ci?no AeAO o ?ia?oiee?a ?? a?oie aoa aeinoia??ii aeua, i?ae o in?a eiio?ieueii? a?oie (?<0.05). Eiao?oe??io aea ??o?no (AnAO/AeAO) o oeeo ?iai/eo neeaa 0,77±0,12, ui aoei ieae/a eiio?ieueieo iieaciee?a (?<0.05). Caeuaiiy AeAo, cieaeaiiy eiao?oe??ioo aea ??o?no o a??iee?a, aeeiioth/eo aaaee? ?iaioe a iaea?eueo iani?eyoeeaeo oiiaao i?aecaiieo ae?iaie, iiaea na?ae/eoe ia ei?enoue oeeoie?co aaiaoioeeo?a, yeee ca`ycaiee c ia?aa??aii. I?e ?icae?eaii? a??iee?a ia a?eia? a?oie aeyaeeinue, ui ci?no caaaeueiiai a?eeo aoa iaea?eueo iecueeei (69,31±1,98 a/e ) o a??iee?a 20-30 ?ie?a. A oe??e aea a?eia?e a?oi? ci?no aeueaoi?i?a aeyaeany iaeiaiueoei oa neeaaeaa 35,77±1,92% oa aeinoia??ii a?ae??ciyany a?ae ??aith aeueaoi?i?a a e?ia? oaooa??a 41-50 ?ie?a (41,98±1,5%; ?<0.05). Ci?no oieanoa?eio a ne?iaaooe? e?ia? a??iee?a ca?eueooaaany c a?eii. I?e oeueiio i?i?iaeueiee ??aaiue (4,44±0,37 iiieue/e) a?aecia/aany o iieiaeeo ?ia?oiee?a, a iaeneiaeueiee (6,1±0,2 iiieue/e) – a noa?o?e a?eia?e a?oi?, c aeinoia??ieie a?aeciaeaie i?ae a?oiaie 20-30 oa 51-60 ?ie?a (?<0.05). ??aaiue -e?iii?ioa?ae?a a ne?iaaooe? e?ia? oaeiae ca?eueooaaany o a??iee?a noa?oi? a?eiai? a?oie o ii??aiyii? c iniaaie 20-30 ?ie?a (?<0.05). ??aaiue AnAO iaa iaea?eueoa cia/aiiy o a?eia?e a?oi? 20-30 ?ie?a (0,22±0.05 iiieue/e /), oa cieaeoaaany aei 0,15±0,02 iiieue/e / a a?oi? 51-60 ?ie?a (?<0.05). I?e ?icae?eaii? a??iee?a ia a?oie ca noaaeai anoaiiaeaii, ui oo?eiaiiy caaaeueiiai a?eeo a ne?iaaooe? e?ia? aoei i?i?iaeueiei i?e noaae? ?iaioe a i?aecaiieo oiiaao aei 5 ?ie?a (66,15±2,1 a/e) oa ia?aaiii??ii ia?inoaa aei iaen?ioia i?e noaae? 21-25 ?ie?a (73,61±2,0 a/e; ?<0.05). Oo?eiaiiy aeueaoi?i?a aoei oaeiae iaeiaioei o ?iai/eo c noaaeai aei 5 ?ie?a (34,55±2,8) oa aeyaeyany cia/ii ieae/a iieaciee?a ca noaaeai a?oi 16-20 oa 21-25 ?ie?a (?<0.05 a iai?o aeiaaeeao). A/A o oaooa??a c noaaeai aei 5 ?ie?a, 5-10 ?ie?a oa 11-15 ?ie?a aoa aeinoia??ii ieae/a, i?ae i?e noaae? 16-20 oa 21-25 ?ie?a (?<0.05 o an?o aeiaaeeao). Oe? ci?ie iiaeooue aooe ca`ycai? ?c oei, ui iieiae? ?iai/? ua ia aaeaiooaaeeny aei aaaeeeo oiia i?aoe?. ??aaiue -e?iii?ioa?ae?a ia?inoaa c i?i?ioia i?e noaae? aei 5 ?ie?a (20,4±2,3iae.) aei iaen?ioia i?e noaae? 21-25 ?ie?a (26,1±3,12 iae.; ?<0.05). Cia/aiiy AeAO cieaeoaaeiny c 0,22±0,07 iiieue/e / i?e noaae? aei 5 ?ie?a, aei 0,16±0,027 iiieue/e / i?e noaae? 16-20 ?ie?a. A?aecia/aia c?inoaiiy ??aith oieanoa?eio oa -e?iii?ioa?ae?a c a?eii oa ca?eueoaiiyi noaaeo ?iaioe c`yno?oueny c caaaeueiiciaeiieie a?eiaeie ci?iaie e?i?aeiiai iai?io. Ioaea, ia iiaeia aoei aeeeth/eoe, ui iieo/ai? aeai? a?io?i?/iiai aeine?aeaeaiiy iaee ?ioiieia?/io i?e?iaeo. I?e aea/aii? ee?oeiiiai oa aoii?aeueiiai eaiie ?ioi?oaoo anoaiiaeaii (oaae. 1), ui o a??iee?a ? a?oie (on? ianoaaeai? a??ieee), o ii??aiyii? c eiio?ieueiith a?oiith, a?aecia/aeinue cieaeaiiy e?eueeino? eaeeioeeo?a (L) (?<0.05) oa e?ioioeeo?a (E) ye a aaniethoieo, oae ? a a?aeiinieo iieacieeao (?<0.05). Oaaeeoey 1 Aieea ni??oe?ie ia iieacieee ?ioiiiai noaoono a??iee?a (I±m) A?oie IieacieeeEiio?ieueia a?oia (n=20)?ia?oiee? aei e?eoaaiiy (n=77)?ia?oiee? i?ney e?eoaaiiy (n=20)L, 109/e7,1±0,25,9±0,2*6,9±0,3E, %30,1±2,020,5±1,1*30,4±1,2109/e2,12±0,111,21±0,16*2,10±0,08CD3, %78,3±1,662,8±0,6*70±2,1*109/e1,7±0,10,76±0,12*1,47±0,11CD4, %48,4±2,134,9±0,7*43±1,8*109/e1,03±0,10,42±0,1*0,9±0,08CD8, %21,1±1,926,6±0,6*25,8±1,3109/e0,45±0,080,32±0,07*0,54±0,05CD-4 / CD-82,29±0,231,31±0,07*1,68±0,12*CD22, %13,8±1,118,5±0,4*17,6±1,4109/e0,29±0,080,22±0,070,37±0,04IgM, a/e1,3±0,11,0±0,05*1,2±0,05IgG, a/e9,5±0,58,058±0,201*8,08±0,174*IgA, a/e2,3±0,11,653±0,084*2,16±0,108Oe?E, a/e1,8±0,12,463±0,064*1,92±0,0801-oeiicei, ia/ie1.2010.1860.6960.07*0,9820,1 * - ??cieoe? aeinoia??i? c iieacieeaie eiio?ieueii? a?oie (?<0,05) Ci?no O-e?ioioeeo?a (CD3), O-oaeia??a (CD4) oa aaniethoia e?euee?noue O-noi?ani??a (CD8) oaeiae aoee cieaeaii? o ii??aiyii? c eiio?ieueiith a?oiith (?<0.05). ?ioiiei?aaoth/ee ?iaeaen (CD4/CD8) o oaooa??a aoa cia/ii ieae/a, i?ae a eiio?ieuei?e a?oi? (?<0.05). I?e ii??aiyii? a?aeiinieo iieaciee?a ci?noo A-e?ioioeeo?a (CD22) aoei anoaiiaeaii ?o ca?eueoaiiy o ?iai/eo (?<0.05), oiae? ye i?e ii??aiyii? aaniethoieo iieaciee?a aeinoia??ieo a?aei?i a ii??aiyeueieo a?oiao aeyaeaii ia aoei. E??i oiai, ci?no IgA, IgG, IgM a e?ia? oaooa??a aoa cieaeaiee (?<0.05). A oie aea /an ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) ?iaeany caeoaiei (?<0.05). I?e aiae?co a?eiaeo ci?i ?ioiiiai noaoono a??iee?a aoei a?aecia/aii, ui a?aeiinia e?euee?noue CD3 c?inoaea c a?eii c i?i?ioia a a?eia?e a?oi? 20-30 ?ie?a (62,11±1,01%) aei iaen?ioia a a?oi? 51-60 ?ie?a (64,85±1,01%). I?e oeueiio, aeinoia??ia ??cieoey a?aecia/aeanue i?ae a?oiaie 31-40 oa 51-60 ?ie?a (?<0.05). Aaniethoi? oa a?aeiini? aaee/eie CD4, CD8, CD4/CD8, CD22 oa ??ai? IgM, IgG, oa IgA aeinoia??ii ia ci?ithaaeenue. I?ioa, ci?no Oe?E cieaeaany c iaen?ioia a a?eia?e a?oi? 20-30 ?ie?a (2,627±0,104 a/e) aei i?i?ioio a 41-50 ?ie?a (2,375±0,082 a/e; ?<0.05). I?e ?icae?eaii? oaooa??a ia a?oie ca noaaeai anoaiiaeaii, ui a?aeiinia e?euee?noue CD3 c?inoaea c i?i?ioia i?e noaae? 5-10 ?ie?a (60,44±0,93%) aei iaen?ioio i?e noaae? 21-25 ?ie?a (65,67±1,07%), c aeinoia??iith ??cieoeath i?ae noaaeaaith a?oiith c noaaeai 21-25 ?ie?a oa a?oiaie aei 5 ?ie?a oa 5-10 ?ie?a (?<0.05 a iaio aeiaaeeao). E?euee?noue CD4 o a?aeiinieo aaee/eiao c?inoaea c iia?eueoaiiyi noaaeo, a?ae 32,4±1,6% i?e noaae? aei 5 ?ie?a aei 37,17±1,65% i?e noaae? 21-25 ?ie?a (?<0.05). CD8 o a?aeiinieo aaee/eiao cieaeaeeny a?ae 29,4±1,86% i?e noaae? aei 5 ?ie?a aei 24,81±1,2% i?e noaae? 11-15 ?ie?a (?<0.05). ?ioiiei?aaoth/ee ?iaeaen aoa i?i?iaeueiee o ?iai/eo c noaaeai aei 5 ?ie?a (1,17±0,08), aeinoia??ii ia ci?ithaaany c ca?eueoaiiyi noaaeo aei 20 ?ie?a, iio?i ca?eueooaaany ? neeaaeaa i?e noaae? 21-25 ?ie?a 1,45±0,1, c aeinoia??ieie a?aei?iaie c ieaaeoith a?oiith ca noaaeai (?<0.05). ??aaiue IgA cia/ii caeuoaaany o oaooa??a c noaaeai 11-15 ?ie?a oa 5-10 ?ie?a, a ii??aiyii? c ?ia?oieeaie c iaeei noaaeai (?<0.05). ??aaiue Oe?E ia?aaiii??ii cieaeoaaany c ca?eueoaiiy i?aecaiiiai noaaeo,oa o in?a c noaaeai 11-15 ?ie?a ? 21-25 ?ie?a aoa noaoenoe/ii aeinoia??ii ieae/a, i?ae o ?iai/eo c noaaeai aei 5 ?ie?a (?<0.05 a iaeaeaao aeiaaeeao). Oaeei /eiii, o an?o ianoaaeaieo a??iee?a niinoa??aaeiny cieaeaiiy ye ee?oeiii?, oae ? aoii?aeueii? eaiie ?ioi?oaoo, ca aeeeth/aiiyi Oe?E, e?euee?noue yeeo ca?eueooaaeinue. Ne?ae a?aei?oeoe, ui cia/ii? caeaaeiino? iniiaieo iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo a?ae aaaeeino? aeeiioth/eo ?ia?o ia aoei a?aei?/aii. Iaea?aeai? ?acoeueoaoe ca?aaeenue c aeaieie aeine?aeaeaiiy ?ioiiiai noaoono o ?iai/eo i?iieneiaeo i?aei?e?inoa, ye? oa?aeoa?ecoaaeenue ?ioiiaeao?oeeoii: O-e?ioiiai??th, ae?naaeainii ?aaoeyoi?ieo noaiiioeyoe?e O-e?ioioeeo?a, i?eai?/aiiyi i?iaeoeoe?? aioeo?e, ca?eueoaiiyi Oe?E oa cieaeaiiyi aeoeaiino? iae?ioaaaeueii? oaaioeeoa?ii? nenoaie ui a oe?eiio icia/aeiny ye aoi?eiiee ?ioiiiaeao?oeeoiee noai (?AeN) ii a?aeiiniiio a?ia?noi?ani?iiio aa??aioo. I?e oeueiio a?aei?/aiee ?ioiiiaeai?aneaiee aieea o?ce/ieo iaaaioaaeaiue. Aeinoia??ia ci?ia ?ioiiiai noaoono a??iee?a iiaea aooe ca`ycaia c ii?ooaiiyi ?aaoeyoe?? ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo, a ca`yceo c /ei aoei i?iaaaeaii aea/aiiy ?ie? ai?iiio oeiono 1-oeiiceia (1O), ye iaeiiai c ?aaoeyoi??a ?ioiii? nenoaie. I?e ?icae?eaii? ?iai/eo caeaaeii a?ae aaaeeino? aeeiioth/eo ?ia?o anoaiiaeaii (oaae. 2) ui ??aaiue 1O o an?o ianoaaeaieo a??iee?a aoa iaa?oue aaea?/? ieae/a, i?ae o in?a eiio?ieueii? a?oie (?<0.05). Oaaeeoey 2 Aieea o?oaea a i?aecaiieo oiiaao ia ci?no 1-oeiiceio (M±m) A?oie IieacieeeeEiio?ieueia a?oia (n=20)I a?oia (n=77)II a?oia (n=34)III a?oia (n=43)1-oeiicei, ia/ie1.2010.1860.6960.07*0.600.08*0.780.13*- ??cieoe? aeinoia??ie c iieacieeaie eiio?ieueii? a?oie (?0,05) I?ioa, iaea?eueoa cieaeaiiy iieacieea a?aei?/aeiny o ?ia?oiee?a ?? a?oie. I?e aea/aii? aieeao a?eo ia ci?io eiioeaio?aoe?? 1O aeyaeeinue (oaaeeoey 3), ui ??aaiue 1O cieaeoaaany c a?eii, i?e oeueiio a a?eiaeo a?oiao 31-40 ?ie?a oa 41-50 ?ie?a a?aei?/aeany oaiaeaioe?y aei cieaeaiiy ??aith 1O a ii??aiyii? c iieiaeeie oaooa?yie oa o in?a 51-60 ?ie?a ci?no ?1O aoa aeinoia??ii ieae/a iieacieea a??iee?a a 20-30 ?ie?a (?<0.05). Aiae?c aieeao i?iieneiaiai noaaeo ia ci?no ?1O a ne?iaaooe? e?ia? iieacaa (oaae.4) , ui iaeneiaeueiei ci?no ?1O aoa o ?ia?oiee?a c noaaeai aei 5 ?ie?a oa i?aeoe/ii ia a?ae??ciyany a?ae ??aith eiio?ieueii? a?oie Oaaeeoey 3 Aieea a?eo ia ci?no 1-oeiiceio (M±m) A?e Iieaciee20-30 ?ie?a (n=13)31-40 ?ie?a (n=39)41-50 ?ie?a (n=14)51-60 ?ie?a (n=11)1-oeiicei, ia/ie0.865+0.070.833+0.160.763+0.190.597+0.16**- ??cieoe? aeinoia??ie c iieacieeaie a?oie 20-30 ?ie?a (p<0.05) Iaaeae?, ci?no 1O ia??aiii??ii cieaeoaaany aei i?i?ioio i?e noaae? 21-25 ?ie?a. I?e oeueiio ??cieoey niinoa??aaeanue i?ae a?oiaie oaooa??a c i?i?iaeueiei noaaeai 21-25 ?ie?a (?<0.05). Oaaeeoey 4 Aieea ae?iaie/iai noaaeo ia ci?no 1-oeiiceio (M±m) Noaae Iieacieeaei 5 ?ie?a (n=6)5-10 ?ie?a (n=17)11-15 ?ie?a (n=25)16-20 ?ie?a (n=13)21-25 ?ie?a (n=16)1O, ia/ie1.030.190.680.090.7820.20.6880.210.5690.13* - ??cieoe? aeinoia??ie c iieacieeaie a?oie aei 5 ?ie?a (p<0.05). Oaeei /eiii, o a??iee?a, aeeiioth/eo aaaee? ?iaioe a iaea?eueo iani?eyoeeaeo oiiaao i?aecaiieo ae?iaie, a?aecia/aeinue cieaeaiiy ??aith 1-oeiiceio a ne?iaaooe? e?ia?. I?e ?icae?eaii? ?iai/eo caeaaeii a?ae a?eo oa i?aecaiiiai noaaeo anoaiiaeaii cieaeaiiy ci?noo ai?iiia o in?a noa?oa 50 ?ie?a oa i?e noaae? a?eueo 20 ?ie?a. I?e i?iaaaeaii? ei?aeyoe?eiiai aiae?co i?ae aea/a?ieie iieacieeaie a eiio?ieuei?e a?oi? noaoenoe/ii aeinoia??ieo cia/aiue ia anoaiiaeaii. Ei?aeyoe?eiee aiae?c o ? a?oie iieacaa, ui 1O iaa iii??io iiaa?iooo ei?aeyoe?eio caeaaei?noue c aaee/eiith CD4 (r= -0,502; ?<0.05) oa ?ioiiei?aaoth/ei ?iaeaenii (r=-0,438; ?<0.05). I?e oeueiio a?aei?/aii i?yiee ei?aeyoe?eiee ca`ycie 1O c CD8 (r=0,476; ?<0.05). A ?? a?oi? oaooa??a noaoenoe/ii cia/oueo ei?aeyoe?eieo ca`yce?a ia niinoa??aaeiny. A ??? a?oi? a??iee?a aeyaeai? ei?aeyoe?? 1O no?aei? c oaeeie, ye a ? a?oi?: iii??ia iaaaoeaia ei?aeyoe?y c CD4 (r=-0,792; ?<0.05) oa CD4/CD8 (r=-0,663; ?<0.05). Ei?aeyoe?eia caeaaei?noue i?ae 1O oa cia/aiiyi Oe?E o ?ia?oiee?a ??? a?oie ia a?aei?io a?ae ? – ia a?aecia/aeanue. Ioaea, o a??iee?a 1O iaa iiaa?iooo caeaaei?noue c O-oaeia?aie oa ?ioiiei?aaoth/ei ?iaeaenii, oa i?yio c O-noi?ani?aie oa Oe?E. A oie aea /an, ca aeaieie ?yaeo aeine?aeaeoaa/?a, 1O ? ?a/iaeiith, yea noeioeth? O-oaeia?e ia oii? ii/aoeiaiai ineaaeaiiy ?ioi?oaoo. Iiaeeeai, cieaeaiiy O-oaeia??a i?eaiaeeoue aei noeioeyoe?? ae?iaee 1O. A oie aea /an, caeuaiiy ci?noo O-noi?ani??a, ye? iiaeooue aaeueioaaoe ooieoe?th O-oaeia??a, i?eaiaeeoue aei noeioeyoe?? ae?iaee 1O aeey oiai, uia i?ioenoiyoe iaaaoeaiiio aieeao O-noi?ani??a ia O-oaeia?i? ee?oeie. Cacia/ai? aeua ci?ie a?io?i?/ieo ? ?ioiieia?/ieo iieaciee?a iiaee na?ae/eoe ia o?eueee i?i ooieoe?iiaeuei?, a e i?i no?oeoo?i? ii?ooaiiy aaiaoioeeo?a. Aeey aeyaeaiiy ?ie? iaeiiai c iaea?eueo iaaacia/ieo oaeoi??a i?aecaiiiai na?aaeiaeua aeeaieeo aoa?eueieo oaoo – aino?iai oa o?ii?/iiai ia?aa??ao a ?icaeoeo ooieoe?iiaeueieo oa ii?oieia?/ieo ci?i oeaieie ia/?iee aoei cae?eniaiii aenia?eiaioaeueia aeine?aeaeaiiy . Ii?oieia?/ia aeine?aeaeaiiy ia/?iee iaoethe?a iieacaei, ui c ca?eueoaiiyi o?eaaeino? ia?aa??ao, a?ae noaae?? oaieiaiai oaea?o (OO) aei noaae?? aaii?? (Aa), iineethaaeenue ci?ie a ia/?ioe?: c?inoaei iiaiie?ia?? i?aaio, a?aecia/aeinue ?icoe?aiiy oeaio?aeueieo aai, iineethaaany ae?aiaaeac a?eo?ioeeo?a /a?ac no?ieo e?iaiiinieo noaeei, ca?eueooaaeeny ?ici??e ee?oei, ia?inoaee aeeno?io?/i? ci?ie a aaiaoioeeoao (A), c`yaeyeeny iae?ice ee?oei. E??i oiai, e?euee?noue aeaoyaea?ieo aaiaoioeeo?a oa eoioa?ianueeeo ee?oei c?inoaea, a a noaae?? Aa cia/ii ciaiooaaeanue. Cieaeaeany e?euee?noue i?oioiiae??e, aoaeiaa e?eno a ieo ii?oooaaeanue, ui a?aecia/aeanue oaeiae ?ioeie. E??i oiai, a aiaeiieaciaoe/iiio ?ao?eoeoio ciaiooaaeanue e?euee?noue oeenoa?i oa iia?eueii ?icoaoiaaieo ??ainii, aea ca?eueooaaeinue /enei e?i?aeieo a?aioe. Ia?inoaee yaeua aaeoieueii? aeeno?io??. A noaae?? Aa niinoa??aaeeny ee?oeie c iiai?noth e?c??iaaiei neeaaeii c ii?ooaiith ieaciieaiith oa aeo?aeii neeaaea ee?oeie o i?ino?? Ae?na. I?e aeaeo?iiii-a?noio?i?/iiio aeine?aeaeaii? a?aecia/aeany iineeaia a?ae noaae?? aei noaae?? aeaoi?iaoe?y, aaceeoeyoe?y oa o?aaiaioaoe?y e?cinii, oi?ioaaiiy c ieo aooioaainii, a oaeiae aca?iia ceeaaiiy oa ?iaeoeaaoe?y. A noaae?? Aa oe? ci?ie ia?a?inoaee a aecioeeoic neeaaeo e?cinii oa ?icn?thaaiiy e?ciniiaeueii? a?ae?ieace eiei e?i?aeieo e?aieei oa i?ae i?aaiaeaie. A oie aea /an, ?ioeie aaoi?aie i?e ia?aa??a? a?eeo iaoethe?a aoei ia na?oiaiio ??ai? a?aecia/aii ca?eueoaiiy aeoeaiino? eenei? oinoaoace a on?o ciiao ia/?ii/ii? aeieueee. A AA a?aecia/aeany c?inoathua aac?eoeyoe?y c ?iciaaeii eiai oeenoa?i ia i?e?iioce?? oa i?iaeoeoe??e iaeao?a e?iii?ioa?aeieo /anoie, aca?iiae?th/eo c e?ciniiaie oa ?o aecioeeoic. Iaaooue, ?oeioaaiiy e?cinii oa aeyaeaiiy EO a oeeoiieaci? ee?oei oa i?inoi?? Ae?na c`yaeeinue i?e/eiith iioeiaeaeaiiy A. Cia/ia cieaeaiiy caaaeueiiai a?eeo o a??iee?a iniiaieo i?ioan?e oa ??cea ciaioaiiy ??aith aeueaoi?i?a o oaooa??a on?o a?oi, ii?ooaiiy ooieoe?? ia/?iee, ii?oieia?/i? ci?ie ia/?iee, ye? aeieeathoue i?e iiaeaethaaii? ie?aieo i?iieneiaeo oaeoi??a aeeaiei? aoa?eueii? oaooe, ui ae?aaeai? ooeeaiiyi ?ioiiiai noaoono oa ?aaoethth/iai ai?iiio 1-oeiiceio (ye? iniaeeai cia/ii i?iyaeany o ?ia?oiee?a iniiaieo i?ioan?e ?iai/eo ca noaaeai) aeiiaaee ?ic?iaee i?io?eaeoe/ieo oa e?eoaaeueieo caoiae?a. Iniaeeao oaaao caa?oaea ia naaa a?oia iieiaeeo ?iai/eo oa oaooa??a c iaaaeeeei ae?iaie/ei noaaeai (aei 5 ?ie?a), o yeeo a?aecia/aeenue iaea?eueo iecuee? iieacieee caaaeueiiai a?eeo oa aeueaoi?i?a, CD4 oa IgA, a oaeiae a?aeiinii? e?eueeino? CD8 oa Oe?E. C iaoith ei?aeoe?? aeua cacia/aieo ii?ooaiue o a??iee?a aeei?enoiaoaaany e?ea?nueeee can?a “Ni??oe?ia”. Aei neeaaeo aoiaeeoue 18 ai?iie?neio, aee?i? e?neioe, i?ia?aeuei? ?a/iaeie, a oaeiae eiiieaen a?oai?i?a. Caaaeyee nai?io neeaaeo “Ni??oe?ia” aieiae?? ?ioiiei?aaoth/eie oa aio?ieneaeaioieie aeanoeainoyie, ui aeicaiey? aeei?enoiaoaaoe ?? c iaoith ei?aeoe?? aeyaeaieo ci?i. I?e aeine?aeaeaii? ?ioiiiai noaoono o i?aecaiieo a??iee?a aeeaiei? aoa?eueii? oaooe i?ney i?iaaaeaiiai eo?no e?eoaaiiy “Ni??oe?iith” aeyaeeinue (oaaeeoey 1), ui ci?no L oa E a e?ia? ca?eueooaaany (?<0.05), oa aaea ia a?ae??ciyany a?ae eiio?ieueiiai ??aith. Ci?no CD3 o oaooa??a i?ney e?eoaaiiy i?aeaeueany (?<0.05), aea, ana ae aoa aeinoia??ii ieae/a iieaciee?a eiio?ieueii? a?oie a a?aeiinieo iieacieeao (?<0.05). Ci?no CD4 a e?ia? o oaooa??a i?ney e?eoaaiiy ca?eueooaaany (?<0.05) ye a aaniethoieo, oae ? o a?aeiinieo aaee/eiao. ??cieoey a ci?noo CD4 i?ae a?oiith ?iai/eo i?ney e?eoaaiiy oa eiio?ieueiith a?oiith o a?aeiinieo aaee/eiao ana ae caeeoaeanue (?<0.05). Ci?no CD8 o a?aeiinieo aaee/eiao o oaooa??a i?ney e?eoaaiiy iaei oaiaeaioe?th, a a aaniethoieo – ca?eueooaaeinue (?<0.05). I?e oeueiio ??aaiueCD8 ?iai/eo i?ney e?eoaaiiy aaea ia a?ae??ciyany a?ae eiio?ieueieo aaee/ei. A?aeiioaiiy CD4/CD8 o oaooa??a i?ney e?eoaaiiy ca?eueooaaeiny (?<0.05), iaeiae, ??cieoey c eiio?ieueiith a?oiith caeeoaeanue (?<0.05). Ci?no CD22 a e?ia? oaooa??a i?ney e?eoaaiiy, a ii??aiyii? c ii/aoeiaeie aeaieie, c?inoaa (?<0.05) a aaniethoieo iieacieeao, iaeiae ia ci?ithaaany o a?aeiinieo oa ia ??cieany c eiio?ieueiith a?oiith. Ci?no IgM ca?eueooaaany o ii??aiyii? c ii/aoeiaei ??aiai (?<0.05), oa aaea ia a?ae??ciyany a?ae eiio?ieueieo aaee/ei. ??aaiue IgG ia ci?ithaaany oa caeeoaany ieae/a eiio?ieueieo iieaciee?a (?<0.05). Ci?no IgA i?aeaeuoaaany (?<0.05) oa i?aeoe/ii ia a?ae??ciyany a?ae ??aith eiio?ieueii? a?oie. ??aaiue Oe?E ciaiooaaany o ii??aiyii? c ii/aoeiaei ci?noii (?<0.05) oa onoaiiaethaaany ia ??ai? eiio?ieueieo iieaciee?a. ??aaiue 1O ca?eueooaaany i?ney e?eoaaiiy (?<0.05) oa aaea ia a?ae??ciyany a?ae eiio?ieueieo iieaciee?a. Oaeei /eiii, o i?aecaiieo a??iee?a aeeaiei? aoa?eueii? oaooe canoinoaaiiy e?ea?nueeiai caniao “Ni??oe?ie” aieeaa? i?aeoe/ii ia on? iieacieee ?ioiia?aie. I?e oeueiio, a?aecia/aii ye iie?ioaiiy iieaciee?a ?ioiia?aie, oae ? caeuaiiy ??aith 1-oeiiceia. A?aecia/ai? ci?ie, iiaeeeai, ca`ycai? c neeaaeii ni??oe?ie. Ana ae ne?ae a?aecia/eoe, ui iiaii? ii?iae?caoe?? ?ioiiiai noaoono ia aeinyaaeinue (ieae/a eiio?ieueieo iieaciee?a aoee CD3, CD4/CD8, IgG), ui iio?aao? iiaeaeueoiai aeineiiaeaiiy iaoiae?a i?io?eaeoeee oa e?eoaaiiy a??iee?a aeeaiei? aoa?eueii? oaooe. AENIIAEE: 1. Aaaeeee o?ce/iee o?oae a oiiaao iaa??aath/iai i?e?iee?iaoo aeeaiei? aoa?eueii? oaooe ni?ey? ?inoo caoai?thaaiino? i?aai?a aaiaoia?e?a?ii? nenoaie o a??iee?a. 2. Oiiae ?iaioe a aeeaie?e aoa?euei?e oaoo? i?eaiaeyoue aei ?icaeoeo ii?ooaiue ooieoe?? ia/?iee, yea i?iyaey?oueny cieaeaiiyi ci?noo caaaeueiiai a?eeo oa aeueaoi?i?a o ne?iaaooe? e?ia?, i?aeaeuaiiyi ??aith AeAO, caeuaiiyi ??aith oieanoa?eio oa -e?iii?ioa?ae?a. 3. O i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo a?aecia/a?oueny ae?aaeaia aeai?an?y ee?oeii? oa aoii?aeueii? eaiie ?ioi?oaoo c ?icaeoeii ?ioiiiaeao?oeeoiiai noaiiaeua ii a?aeiinii a?ia?noi?ani?iiio aa??aioo. Ci?ie ?ioiiiai noaoono i?aecaiieo a??iee?a aeeaiei? aoa?eueii? oaooe i?aeoe/ii ia caeaaeaoue a?ae a?eo oaooa??a oa iia`ycai? c noaaeai a i?aecaiieo oiiaao 4. A ?icaeoeo ?AeN o a??iee?a i?eeia? o/anoue ai?iii 1-oeiicei, yeee cia/ii cieaeo?oueny, a a?eueoiio nooiai?, o in?a, ye? aeeiiothoue aaaee? ?iaioe a iaea?eueo iani?eyoeeaeo oiiaao a??ieo ae?iaie. 5. Aino?ee oa o?ii?/iee ia?aa??a oaa?ei a aenia?eiaioaeueiiio aeine?aeaeaii? i?eaiaeeoue aei ?icaeoeo aeeno?io?/ieo ci?i oa iae?ic?a a aaiaoioeeoao, iaea?eueo ae?aaeaieo i?e o?ii?/iiio ia?aa??a?. Iaoai?ci ?icaeoeo iioeiaeaeaiiy aaiaoioeeo?a ca`ycaiee c ii?ooaiiyi ?iaioe e?ciniiaeueii-aaeoiey?iiai aia?aoo ee?oei, aeanoaa?e?caoe?? e?ciniiaeueieo iaia?ai oa aeo?aeii a?ae?ie?oe/ieo oa?iaio?a a oeeoiieacio oa ca iaae? ee?oei. 6. A?oiith iaea?eueo i?aeaa?aeaieo aieeao oe?aeeeaeo oaeoi??a aeeaiei? aoa?eueii? oaooe ? iieiae? ?iai/? (20-30 ?ie?a) oa iniae c iaaaeeeei noaaeai (aei 5 ?ie?a), o yeeo niinoa??aathoueny iaea?eueo iecuee? iieacieee caaaeueiiai a?eeo oa aeueaoi?i?a, CD4 oa IgA, a oaeiae caeuaiiy a?aeiinii? e?eueeino? CD8 oa Oe?E. 7. Niiaeeaaiiy e?ea?nueeiai caniao “Ni??oe?ia” o i?aecaiieo a??iee?a aeeaiei? aoa?eueii? oaooe i?eaiaeeoue aei iie?ioaiiy iieaciee?a ?ioiiiai noaoono oa ?aeiiaiaeo?oueny aeey i?io?eaeoe/iiai e?eoaaiiy. NIENIE ?IA?O AAOI?A, UI IIOAE?EIAAI? CA OAIITH AeENA?OAOe?? 1. Ieoeoiae I.E., Ieioeei A.ss, ?aa?ia A.A, Iiaaaeaiiay A.I., No?ieei I.A. Aeeyiea yeciaaiiie aeia?oa?iee ia ii?oieiae/aneoth no?oeoo?o ii/ae e ia/aie // Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia /iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, 1998. - N. 116-130. 2. Ieoeoiae I.E., Ieioeei A.ss., Iiaaaeaiiay A.I., No?ieei I.A. Aaiaoiaeeea?iay nenoaia // Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia /iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, 1998.- N.169-181. 3. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Ii?oieiae/aneea eciaiaiey ia/aie i?e ino?ii e o?iie/aneii ia?aa?aaaiee // Oe?a?inueeee iaaee/iee aeueiaiao.- 1998.- ?3.- N.56-59. 4. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A., Ieeeoeia E.A. I?eiaiaiea nie?oeeiu a oeaeyo i?ioeeaeoeee ino?eo i?inooaeieo caaieaaaiee o oaooa?ia // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.-?24.- N.98-101. 5. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Aeeyiea ino?iai e o?iie/aneiai ia?aa?aaaiey ia ii?oieiae/aneea eciaiaiey ia/aie // E?ea?nueea ni?aaa. - 1998. - ?8. – N.85-88. 6. Ieoeoiae I.E. Aeeyiea ?aaiou a oneiaeyo aeoaieie oaieueiie oaoou ia niaea?aeaiea 1-oeiiceia a nuai?ioea e?iae ai?ii?aai/eo // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. -?6. –N.58-60. 7. Ieoeoiae I.E. ?aiiea eeeieei-eaai?aoi?iua i?iyaeaiey caaieaaaiee ia/aie o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo Aeiiaanna // Oe?a?inueeee iaaee/iee aeueiaiao. – ?2. – 1999. – N.98-101. 8. I?oeoiae I.?., Ieioe?i A.ss., ?aa?ia A.I. Niin?a i?io?eaeoeee caoai?thaaiue eaaai?a oa aa?oi?o aeeoaeueieo oeyo?a // IAOAIO ia aeiao?ae UA 21063 IEE A61 E35/80, Athe.”I?iieneiaa aeani?noue”, 1998, ?1.-4 N. 9. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Eciaiaiey ii?oieiae/aneie no?oeoo?u ia/aie i?e ino?ii e o?iie/aneii ia?aa?aaaiee // ”Aeooaeuei? ieoaiiy ii?oieia??” II Iaoe. eiia?. AAAO Oe?a?ie, Eoaainuee, 16-19 aa?aniy 1998, /Oac. Aeii./ N. 203-204. 10. I?oeoiae I.?., ?aa?ia A.I. Ci?ia a?io?i?/ieo iieaciee?a ia/?iee o a??iee?a aeeaieeo aoa?eueieo oaoo Aeiiaano // XIV c’?cae oa?aiaao?a Oe?a?ie. Ee?a, 1998.- N. 410-413. 11. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Aeeyiea oyaeanoe o?oaea a iiaecaiiuo oneiaeyo ia niaea?aeaiea 1-oeiiceia a e?iae // Ca. i?aoeue I iaoe?iiaeueiiai eiia?ana Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aa-a?e?oaoe??. Aeoooa, E?ei, 13-15 o?aaiy, 1998.- n. 49. 12. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Ei??aeoeey eciaiaiee eiioiiiai noaoona o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo // Oinoa anaoe?a?inueea ia?aaea c ieoaiue iie?ee?i?/ii? ni?aae. Ca??iee iaoeiaeo ?ia?o. Euea?a, 1997.- N.14-15. 13. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A., Iiaaaeaiiay A.I. Oneeaiea i?ioeannia ia?aeeniiai ieeneaiey eeieaeia eae oaeoi? ?enea ii?aaeaiey ia/aie o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo // ”Iaaeeei-a?ieiae/i? i?iaeaie i?iieneiaiai ?aa?iio”.Na. iao/. Noaoae. EAIO, 1997.- N.160-163. 14. Ieoeoiae I.E., Ieioeei A.ss., ?aa?ia A.A. Eciaiaiey ii?oieiae/aneie no?oeoo?u ia/aie i?e o?iie/aneii ia?aa?aaaiee // Iaoa?.?anioae?eainueei? iaoeiai-i?aeoe/ii? eiioa?aioe?? “Aeinyaiaiiy oa iaae??oai? ieoaiiy aano?iaioa?ieia??”, Oa?e?a, 1998. – N.148 AIIOAOe?ss I?oeoiae I.?. Ee?i?ei-iaoiaaiaoe/i? iniaeeaino? ?icaeoeo caoai?thaaiue ia/?iee o a??iee?a aeeaieeo aoa?eueiee oaoo Aeiiaano ? oeyoe ?oiuei? i?io?eaeoeee. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe. 14.01.02. – aioo??oi? oai?iae. – Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie, Eoaainuee, 1999. O i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo a?aecia/a?oueny cieaeaiiy ai?noo caaaeueiiai a?eeo oa aeueaoi?i?a o ne?iaaooe? e?ia?, i?aeaeuaiiy ??aith AeAO, caeuaiiy ??aith oieanoa?eio oa -e?iii?ioa?ae?a, iniaeeai o a??iee?a iniiaieo i?ioan?e, iieiaeeo a??iee?a oa in?a c noaaeai ?iaioe aei 5 ?ie?a. A ?icaeoeo ?ioiiaeao?oeeoiiai noaiiaeua o a??iee?a i?eeia? o/anoue ai?iii 1-oeiicei, yeee cia/ii cieaeo?oueny, a a?eueoiio nooiai?, o in?a, ye? aeeiiothoue aaaee? ?iaioe a iaea?eueo iani?eyoeeaeo oiiaao a??ieo ae?iaie. Niiaeeaaiiy e?ea?nueeiai caniao “Ni??oe?ia” ?aeiiaiaeo?oueny aeey i?io?eaeoe/iiai e?eoaaiiy Eeth/ia? neiaa: ?ioiiaeao?oeeoiee noai, a??ieee, a?iiaeueaoi?iai?y, ii?ooaiiy ooieoe?? ia/?iee, 1-oeiicei, “Ni??oe?ia”. AIIIOAOeEss Ieoeoiae I.E. Eeeieei-iaoiaaiaoe/aneea iniaaiiinoe ?acaeoey caaieaaaiee ia/aie o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo Aeiiaanna e iooe eo i?ioeeaeoeee. – ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe.14.01.02 – aioo?aiiea aieacie.- Eoaaineee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao IC Oe?aeiu, Eoaaine, 1999. O i?aeoe/anee caei?iauo ai?iyeia aeoaieie oaieueiie oaoou i?iaaaeaii eiiieaeniia eco/aiea ?aiieo ia?ooaiee ooieoeeiiaeueiiai ninoiyiey ia/aie, eioiiiai noaoona e ai?iiia oeiona 1-oeiiceia eae oaeoi?ia ?ecea caaieaaaiey ia/aie. Oyaeaeue oece/aneee o?oae a oneiaeyo iaa?aaathuaai iee?ieeeiaoa aeoaieie oaieueiie oaoou i?eaiaeeo e ?acaeoeth ia?ooaiee ooieoeee ia/aie, i?iyaeythuaeny a nieaeaiee niaea?aeaiey aeueaoieiia a nuai?ioea e?iae, iniaaiii cia/eoaeueiua o iieiaeuo ai?ii?aai/eo e oaooa?ia n iiaecaiiui noaaeai aei 5 eao; ioiineoaeueiii iiauoaiee o?iaiae o?ainaieiac, o?iaiy oieanoa?eia e -eeiii?ioaeaeia a nuai?ioea e?iae, i?aeiouanoaaiii o ?aai/eo iniiaiuo i?ioannee, auiieiythueo oyaeaeua ?aaiou a iaaeaaii?eyoiuo oneiaeyo ai?iuo au?aaioie. Ino?ia e o?iie/aneia ia?aa?aaaiea aeeaioiuo a yenia?eiaioaeueiii enneaaeiaaiee i?eaiaeeo e ?acaeoeth aeeno?ioe/aneeo eciaiaiee e iae?icia a aaiaoioeeoao, iaeaieaa au?aaeaiiuo i?e o?iie/aneii ia?aa?aaaiee. Iaoaieci ?acaeoey iia?aaeaeaiey aaiaoioeeoia naycai n ia?ooaieai ?aaiou eeciniiaeueii-aaeoiey?iiai aiia?aoa eeaoie, aeanoaaeeecaoeeae eeciniiaeueiuo iaia?ai e auoiaeii aeae?ieeoe/aneeo oa?iaioia a oeeoiieacio e ca i?aaeaeu eeaoie. O i?aeoe/anee caei?iauo iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo ioia/aaony au?aaeaiiay aeai?anney eeaoi/iiai e aoii?aeueiiai caaiueaa eiioieoaoa n ?acaeoeai eiioiiaeaoeoeeoiiai ninoiyiey ii ioiineoaeueii aeia?noi?anni?iiio aa?eaioo. Eciaiaiey eiioiiiai noaoona iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo i?aeoe/anee ia caaenyo io aic?anoa oaooa?ia, e naycaiu ni noaaeai ?aaiou a iiaecaiiuo oneiaeyo. A ?acaeoee eiioiiiaeaoeoeeoiiai ninoiyiey o ai?ii?aai/eo i?eieiaao o/anoea ai?iii 1-oeiicei, eioi?ue cia/eoaeueii nieaeaaony, i?e/ai a aieueoae noaiaie o eeoe, auiieiythueo oyaeaeua ?aaiou a iaeaieaa iaaeaaii?eyoiuo oneiaeyo ai?iuo au?aaioie. A?oiiie, iaeaieaa iiaeaa?aeaiiie aicaeaenoaeth a?aaeiuo oaeoi?ia aeoaieie oaieueiie oaoou, yaeythony iieiaeua ?aai/ea (20-30 eao) e eeoea n iaaieueoei iiaecaiiui noaaeai (aei 5 eao), o eioi?uo iaaethaeathony iaeaieaa ieceea iieacaoaee iauaai aaeea e aeueaoieiia, CD4 e IgA, a oaeaea iiauoaiea ioiineoaeueiiai eiee/anoaa CD8 e OeEE. Ei??aeyoeeiiiue aiaeec o anao ai?ii?aai/eo iieacae, /oi 1-oeiicei eiae oia?aiioth ia?aoioth ei??aeyoeeiiioth caaeneiinoue n aaee/eiie NAe4 e eiioiiei??aae?othuei eiaeaenii. I?e yoii ioia/aia i?yiay ei??aeyoeeiiiay naycue 1-oeiiceia n NAe8. E?iia oiai, ?1-oeiicei e aaee/eia OeEE auee naycaiu oia?aiiie i?yiie naycueth. Ai a?oiia oaooa?ia iniiaiuo i?ioannee noaoenoe/anee cia/eiuo ei??aeyoeeiiiuo naycae ia iaaethaeaeinue. A a?oiia ai?ii?aai/eo, auiieiythueo aniiiaaaoaeueiua ?aaiou, auyaeaiu ei??aeyoeee 1-oeiiceia: oia?aiiay io?eoeaoaeueiay ei??aeyoeey n NAe4 e NAe4/NAe8. Ei??aeyoeeiiiay caaeneiinoue iaaeaeo, 1-oeiiceiii e aaee/eiie OeEE o ?aai/eo aniiiaaaoaeueiuo i?ioannee , a ioee/ea io iauae a?oiiu ai?ii?aai/eo – ia ii?aaeaeyeanue. ?ac?aaioai e ai?iae?iaai iiaue iaoiae i?ioeeaeoeee caaieaaaiee ia/aie o ai?ii?aai/eo iooai i?eiaiaiey i?aia?aoa "Nie?oeeia". 20 ai?ii?aai/eo i?eieiaee “Nie?oeeio” ii 2 oaaeaoee (1 a) o?e ?aca a aeaiue a oa/aiea 7-10 aeiae. ?acoeueoaou enneaaeiaaiee iiaeii oe?iei eniieueciaaoue a i?aeoe/aneii cae?aaiio?aiaiee aeey i?ioeeaeoeee caaieaaaiee ia/aie o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo iooai ei??aeoeee eiioiiiai noaoona e o?iaiy ai?iiia oeiona 1-oeiiceia. Iieo/aiiua aeaiiua /aoei oeacuaatho ia iaiaoiaeeiinoue aaaaeaiey ii?aaeaeaiey ooieoeeiiaeueiuo iieacaoaeae ia/aie a iaycaoaeueiue ia?a/aiue enneaaeiaaiee i?e i?iaaaeaiee ia?eiaee/aneeo i?ioeeaeoe/aneeo iniio?ia o ?aai/eo iniiaiuo i?ioannee aeoaieeo oaieueiuo oaoo. Iaiaoiaeeii i?iaiaeeoue aaeaaiaeiua enneaaeiaaiey o eeoe, ioianaiiuo e a?oiiai ?enea, ninoiyiey eiioiiie nenoaiu e o?iaiy ai?iiia 1-oeiiceia aeey auyaeaiey eiioiiaeaoeoeeoiuo ninoiyiee n oeaeueth naiaa?aiaiiie eo ei??aeoeee. Eeth/aaua neiaa: eiioiiaeaoeoeeoiia ninoiyiea, ai?ii?aai/ea, ia?ooaiea ooieoeee ia/aie, aeiiaeueaoieiaiey, 1-oeiicei, “Nie?oeeia”. SUMMARY Nishkumai O.I. Risk factors of liver disease development in the miners of Donbass deep coal mine and the ways of their prevention.- Manuscript. Thesis is submitted for Candidate`s degree in Medicine 14.01.02.inner diseases, Luhansk State Medical University Ministry of Health, Ukraine, Luhansk, 1999. The work presents the complex examination results of dynamic state of liver, immunal status, concentration of the regulating factor of immunal system – 1-thymosin hormone thymus and the methods to prevent the determined distrurbances in the miners of Donbass deep coal mine were invented. It has been determined yhat liver function disturbance is observed in miners. Immune deficiency by the relatively hypersuppressisle variant appears, in the development of which a1-thymosin concentration decrease takes an active part in the blood serum. For the correction of the determined disturbance the method of preventive proteine vitamin-mineral “Spirulina” use was worked out. Key terms: Immune deficiency, liver function disturbance, 1-thymosin, “Spirulina”.

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