EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO AI?AeAI?IEIA?? OA ?IOAEOe?EIEO
OAI?IA ?i. E.A.A?IIAOAANUeEIAI

Aeoaeinueea aaeeia ieoaee?aia

OAeE 616.931+612.015.39+616–003.725

ee?i?ei-iaoiaaiaoe/ia cia/aiiy ii?ooaiue o nenoai? aioeieneaeaioiiai
caoenoo i?e aeeooa??ei?e ?ioaeoe?? oa ?ic?iaea iaoiae?a ?o ei?aeoe??

14.01.13 ?ioaeoe?ei? oai?iae

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oe?a?inuee?e iaaee/i?e noiiaoieia?/i?e aeaaeai??

Iaoeia? eiinoeueoaioe: Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,
aeieoi? iaaee/ieo iaoe, i?ioani?

Aiae?ueia A?eoi? Ieeieaeiae/, caa?aeoaa/ eaoaae?e ee?i?/ii?
oa?iaeieia?? Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai??.

Io?oe?ei? iiiiaioe: Aeieoi? iaaee/ieo iaoe, aeaaeai?e AII Oe?a?ie

AOOAIEI Aaiiaae?e Ieoaeeiae/, caa?aeoaa/ eaai?aoi??? iaoieia?/ii?
o?c?ieia?? oa ?ioiieia??, canooiiee aee?aeoi?a c iaoeiai? ?iaioe
?inoeoooo aa?iioieia?? AII Oe?a?ie.

Caneoaeaiee e?ea? Oe?a?ie, aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee

?OAeAIEI Aioii?ia Ieaen??aia, caa?aeoaa/ a?aeae?eo oneeaaeiaieo oi?i
a?eio, A?C oa iae?i?ioaeoe?e EIAe? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A.A?iiaoaanueeiai, aieiaiee ?ioaeoe?ii?no IIC Oe?a?ie.

Aeieoi? iaaee/ieo iaoe, i?ioani?

I?E?O?I ?aaai Aaneeueiae/, caa?aeoaa/ eaoaae?e ?ioaeoe?eieo oai?ia oa
ai?aeai?ieia?? Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a ?ioaeoe?eieo oai?ia oa ai?aeai?ieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny «21» /a?aiy 1999 ?.

i 10 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.614.01
i?e Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa
?ioaeoe?eieo oai?ia ?i.E.A.A?iiaoaanueeiai ca aae?anith: 252015,
i.Ee?a-15, aoe.N?/iaaiai iianoaiiy, 23

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i.E.A.A?iiaoaanueeiai

Aaoi?aoa?ao ?ic?neaiee «20» o?aaiy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe A.Ae.Aiae

Aeooaeuei?noue oaie. C 1991 ?ieo i?ney a?aeiinii o?eaaeiai
ai?aeai?ieia?/iiai aeaaiiieo//y ia oa?eoi??? Oe?a?ie i?aeaeueany ??aaiue
caoai?thaaiino? ia aeeooa??th, ui aeicaieeei eiinoaooaaoe iayai?noue
ai?aeai?? (E.I. *oaeiay e niaao., 1995; AE.?.Aic?aiiaa, 1996;
A.?.Iinothe ? ni?aaao., 1996). Caaaeyee i?iaaaeaiith iecee ??ciiiai?oieo
caoiae?a, ni?yiiaaieo ia e?ea?aeaoe?th ai?aeai??, a inoaii? ?iee
caoai?thaai?noue ia aeeooa??th ii/aea ciaiooaaoeny, aea ia oeueiio oii?
cia/ii ca?eueoeeanue ieoiia aaaa oyaeeeo oa oneeaaeiaieo oi?i, c?inee
iieacieee nia?oiino? (A.I.?oaeaiei ? ni?aaao., 1993; TH.A.Aa?ooaei ?
ni?aaao., 1996; A.?.Iinothe ? ni?aaao., 1996; I.O.Oo?ueyiia e niaao.,
1996 oa ?io?). Cia/iith i??ith iniaeeaino? no/aniiai ia?aa?ao aeeooa???
iaoiiaeai? cieaeaiiyi ii??iino? ianaeaiiy aei ?ioaeoe?e a oiiaao
nioe?aeueii-aeiiii?/ieo iaaa?acae?a oa iia??oaiiy aeieia?/ii? neooaoe??
(TH.A.Aa?ooaei, 1993; 1998; A.I.I?aeyi ? ni?aaao., 1998; I.I.C?i/oe ?
ni?aaao.,1998).

Ca?aeii c aeaieie e?oa?aoo?e, iaei??th c iniiaieo eaiie iaoiaaiaco
ii?ooaiue aiiainoaco, ye? iathoue i?noea aiane?aeie ae?? ia i?aai?ci
iani?eyoeeaeo oaeoi??a ciai?oiueiai na?aaeiaeua, ? aeoeaaoe?y ?aaeoe?e
a?eueii?aaeeeaeueiiai ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) oa
aeniaaeaiiy ?aca?aieo iiaeeeainoae aioeieneaeaioii? nenoaie (AIN)
(I.A.Iiaa?aceeia e niaao., 1989; A.I.Eoeueyiiaa e niaao., 1995).
Aeiaaaeaii, ui iaaei??ia aeoeaaoe?y ?aaeoe?e a?eueii?aaeeeaeueiiai IIE
i?e ?ioaeoe?eieo caoai?thaaiiyo i?ecaiaeeoue aei c?inoaiiy oyaeeino?
ia?a-a?ao oa ?icaeoeo oneeaaeiaiue, ? aieiaiei aai aeiaeaoeiaei
iaoai?ciii aeano?oeoeaieo ci?i ia noaee?oeiiiio, ee?oeiiiio oa i?aaiiiio
??aiyo, iaoiiaeth? ii?ooaiiy aaeaioaoe?eii-i?enoinoaaeueieo i?ioean?a
(E.E.A?iiaoaaneay, 1997; TH.A.Aa?ooaei, 1998 oa ?io?). Ie?ai?
aeine?aeaeaiiy inoaii?o ?ie?a na?ae/aoue i?i aaaeeeao ?ieue ?aaeoe?e IIE
oa ii?ooaiue AIN o iaoiaaiac? aeeooa???, iniaeeai – ?? oneeaaeiaieo oi?i
(A.I.Iaeee ? ni?aaao., 1995; A.A.Iaeueiee e niaao., 1996;
I.I.?cthinueea, 1998 oa ?io?). Iineeeeanue oaaaa aeine?aeiee?a aei
ioe?iee aioeieneaeaioiiai iioaioe?aeo i?e iin?enoa? ei?eiaaaeoa??e
aeeooa??? (C.d.) o ca’yceo c aeiaaaeaiith iiaeeea?noth o?ainoi?iaoe??
iaoieneaaiieo ooai?a caoaeieea o oieneaaii?, a oaeiae ?iia??i?noth
aeeooa??? o iin??a i?e i?eai?/aii? aioeoiene/iiai ?ioi?oaoo aiane?aeie
ae?? ia i?aai?ci iani?eyoeeaeo aioo??oi?o ? ciai?oi?o oaeoi??a
(AE.?.Aic?aiiaa ? ni?aaao., 1993; A.?.Iinothe ? ni?aaao., 1996;
E.N.Iae?aniaa, ?.I.Ai?aaiue, 1997). Iaaieioo?oueny ia iaiao?aeiino?
aeine?aeaeaiiy ii?ooaiue o nenoaiao IIE oa aioeieneaeaioiiai caoenoo ye
i??i?eoaoieo i?e ?ic?iaoe? cania?a e?eoaaiiy (?.?.Aeaieeaiei, 1998).
AE.?.Aic?aiiaa ? ni?aaao. (1993) i?aee?aneththoue aeioe?euei?noue
aeei?enoaiiy aioeieneaeaioieo i?aia?ao?a o eiiieaeni?e oa?ai?? oai?eo c
aeeooa??eiei i?iea?aeeoii. C oni?oii aeei?enoaee aioeieneaeaioe (AI) i?e
e?eoaaii? oai?eo ? caiia?aee ?icaeoeia? oneeaaeiaiue aeeooa???
A.A.Eaaaae?a ? ni?aaaoi?e (1996), A.A.*i?iia?e ? ni?aaao. (1998).

Aiae?c aeaea?ae e?oa?aoo?e na?ae/eoue i?i ia?niaeoeai?noue
aeine?aeaeaiiy a?eueii?aaeeeaeueieo iaoai?ci?a ? noaio AIN o iaoiaaiac?
aeeooa??? oa aeeooa??eiiai aaeoa??iiin?enoaa, iniaeeai o no/anieo oiiaao
i?aeaeuaiiai aieeao iani?eyoeeaeo aeieia?/ieo oaeoi??a. Aeooaeueiei
caaaeaiiyi nueiaiaeaiiy ? ?ic?iaea iaoiaaiaoe/ii iaa?oioiaaieo cania?a
oa?iaeiei?aeoe?? oa oa?iaeii?io?eaeoeee ii?ooaiue o cacia/aieo nenoaiao.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoa – ia iniia? aenia?eiaioaeueieo ?
ee?i?/ieo aeine?aeaeaiue c’ynoaaoe ?ieue a?eueii?aaeeeaeueieo iaoai?ci?a
? ii?ooaiue o aioeieneaeaioi?e nenoai? a iaoiaaiac? aeeooa??? ?
aeeooa??eiiai aaeoa??iiin?enoaa oa ?ic?iaeoe caniae iaoiaaiaoe/ii?
oa?iaeiei?aeoe?? aeyaeaieo ii?ooaiue.

Aeinyaiaiiy iinoaaeaii? iaoe ia?aaeaa/a? ?ica’ycaiiy oaeeo caaaeaiue:

1. Aeine?aeeoe ?ioaineai?noue ?aaeoe?e a?eueii?aaeeeaeueiiai IIE oa noai
AIN o e?ia? oa oeaieiao ??cieo i?aai?a oaa?ei ca oiia aenia?eiaioaeueii?
aeeooa??eii? ?ioieneeaoe??.

2. I?iaiae?coaaoe iieacieee IIE oa oa?iaio?a AIN o oai?eo ia aeeooa??th
a aeeiai?oe? caeaaeii a?ae ee?i?/ii? oi?ie, oyaeeino? ia?aa?ao oa
iayaiino? oneeaaeiaiue.

3. Ia i?aenoaa? i?iaaaeaieo aenia?eiaioaeueieo ? ee?i?/ieo
aeine?aeaeaiue cai?iiiioaaoe aeiaeaoeia? e?eoa??? ae?aaiinoeee oyaeeiai
oa oneeaaeiaiiai ia?aa?ao aeeooa???.

4. Aea/eoe iieacieee a?eueii?aaeeeaeueiiai IIE, ioe?ieoe noai AIN oa
?ioi?oaoo o iin??a oieneaaiieo (N.d.tox+) ? iaoieneaaiieo (C.d.tox–)
ooai?a ei?eiaaaeoa??e aeeooa???.

5. Aeine?aeeoe aeoeai?noue ?aaeoe?e a?eueii?aaeeeaeueiiai IIE, iieacieee
AIN oa ?ioi?oaoo o ethaeae ?c i?aeaeuaiith ni?eeiyoeea?noth aei
?ioaeoe?e aeeoaeueieo oeyo?a.

6. Iaa?oiooaaoe oa aea/eoe aoaeoeai?noue canoinoaaiiy aiaeii-nie?oiaiai
aeno?aeoo ao?iaoea? io?io?iai? o eiiieaeni?e oa?ai??? iin??a C.d., a
oaeiae ye caniao, ui i?aeaeuo? ii??i?noue aei ?ioaeoe?e aeeoaeueieo
oeyo?a o in?a c? cieaeaiei ??aiai ?acenoaioiino?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Io?eiaii iia? aeai?, ye?
na?ae/aoue, ui ca oiia aenia?eiaioaeueii? aeeooa??eii? ?ioieneeaoe?? o
oeaieiao aioo??oi?o i?aai?a a?aei?/a?oueny iineeaiiy ?aaeoe?e
a?eueii?aaeeeaeueiiai IIE. Nooi?iue ?o aeoeaaoe?? caeaaeeoue a?ae
?aca?aieo iiaeeeainoae aioeieneaeaioieo nenoai aeine?aeaeaieo i?aai?a,
oa?iaioaoeaia eaiea yeeo a oiiaao aeeooa??eii? oienai?? aeyaey?oueny
i?eai?/aiith. Iaeneiaeueii ae?aaeai? ii?ooaiiy o nenoai? IIE–AIN iathoue
i?noea o i?iea?ae? oa naeac?ioe?. Aiaei?ic/eiiee AI i?yii? ae??
aiienei?i, aaaaeaiee o ?aii? no?iee aeeooa??eii? ?ioieneeaoe??, aaeueio?
iaaei??io aeoeaaoe?th ?aaeoe?e a?eueii?aaeeeaeueiiai IIE ? ni?ey?
caa?aaeaiith ooieoe?iiaeueii? aeoeaiino? AIN, ui oaeiae i?aeoaa?aeaeo?
?ieue a?eueii?aaeeeaeueieo iaoai?ci?a o iaoiaaiac? aeeooa??eii?
oienai??.

O oai?eo ia aeeooa??th aeine?aeaeaiee noai i?ioean?a IIE oa aeoeai?noue
oa?iaio?a AIN caeaaeii a?ae ee?i?/iiai ia?aa?ao oa ia??iaeo
caoai?thaaiiy ? aeiaaaeaiee aca?iica’ycie iineeaiiy IIE oa ii?ooaiue o
AIN c? c?inoaiiyi oyaeeino? ia?aa?ao oa ?icaeoeii oneeaaeiaiue
aeeooa???. Anoaiiaeaia caeaaei?noue ?icaeoeo iiiaeeiieo oneeaaeiaiue
aeeooa??? oa iiaeeaeaiiy nooiaiy ?o oyaeeino? c aeniaaeaiiyi ?aca?aieo
iiaeeeainoae AIN. C o?aooaaiiyi no/anieo e?eoa???a ae?aaiinoeee ooi/iai?
iciaee ?aiiueiai ?ici?ciaaaiiy oa i?iaiicoaaiiy oneeaaeiaieo oi?i
aeeooa??? oa aecia/aiiy oyaeeino? ?? ia?aa?ao.

Iieacaii, ui iin?enoai C.d. ia? i?noea i?e cieaeaii? ooieoe?iiaeueii?
aeoeaiino? i?noeaaiai oa ee?oeiiiai ?ioi?oaoo, a oaeiae i?e i?eai?/aii?
oa?iaioaoeaii? eaiee AIN.

Eiiieaenii ioe?iaia niaoeeo?/ia oa?iaeieia?/ia aeoeai?noue
aiaeii-nie?oiaeo aeno?aeo?a ao?iaoea? io?io?iai? ye cania?a e?eoaaiiy oa
i?io?eaeoeee a?eueii?aaeeeaeueiiai ooeiaeaeaiiy i?aai?a ? oeaiei,
aecia/aiee a?aeiiaethaaeueiee aieea i?aia?ao?a ia noai ?ioiii? oa
aioeieneaeaioii? nenoai. Ia i?aenoaa? io?eiaieo aeaieo iaa?oioiaaia
i?ecia/aiiy aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? iaoe??ioai
c? cieaeaiei ??aiai ?acenoaioiino? oa aeiaaaeaii, ui eiai i?eeii
iineeth? ii??i?noue aei ?ioaeoe?e aeeoaeueieo oeyo?a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeine?aeaeaiiy aeeiai?ee
iieaciee?a i?iieneaeaioii-aioeieneaeaioiiai aiiainoaco o oai?eo ia
aeeooa??th aeicaieeei ?aeiiaiaeoaaoe aecia/aiiy iieaciee?a IIE ? AIN ye
aeiaeaoeiaeo e?eoa???a ae?aaiinoeee oyaeeiai oa oneeaaeiaiiai ia?aa?ao
caoai?thaaiiy, ye? i?aeaeuothoue ye?noue aeeoa?aioe?aeueii? ae?aaiinoeee
aeeooa??? oa ?? oneeaaeiaiue ? ai?iaaaeaeai? o i?nuee?e ee?i?/i?e
?ioaeoe?ei?e e?ea?i? i.Iieoaae, ?ioaeoe?eiiio a?aeae?eaii? 1-? i?nueei?
ee?i?/ii? e?ea?i? i.Iieoaae, iaeani?e ?ioaeoe?ei?e ee?i?/i?e e?ea?i?
i.Oa?eiaa.

Ia i?aenoaa? io?eiaieo aenia?eiaioaeueieo ? ee?i?/ieo aeaieo aeiaaaeaia
iaiao?aei?noue canoinoaaiiy AI ye cania?a e?eoaaiiy oa i?io?eaeoeee
oyaeeeo ? oneeaaeiaieo oi?i aeeooa??? oa ?ic?iaeai? oiiae aeei?enoaiiy
aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? o eiiieaeni?e oa?ai??
iin??a C.d.

?acoeueoaoe aeine?aeaeaiiy aeicaieeee oaeiae ?aeiiaiaeoaaoe aeei?enoaiiy
aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? ye caniao e?eoaaiiy ?
i?io?eaeoeee a?eueii?aaeeeaeueiiai ooeiaeaeaiiy i?aai?a ? oeaiei (iaoaio
Oe?a?ie ?9481A), a oaeiae ye caniao ii?iae?caoe?? oeaieiiiai iai?io ?
a?aeiiaeaiiy ii?oiooieoe?iiaeueiiai noaio i?aai?a ? oeaiei (??oaiiy i?i
aeaea/o iaoaioo Oe?a?ie a?ae 11.11.1998 ?. ca cayaeith ?980020682 a?ae
09.02.1998 ?.), ai?iaaaeaeaiiy yeeo o ee?i?/io i?aeoeeo i?aeaeuo?
aoaeoeai?noue ?aaa?e?oaoe?eii? oa?ai?? in?a c? cieaeaiei ??aiai
?acenoaioiino? ? ni?ey? i?aeaeuaiith ii??iino? aei ?ioaeoe?e aeeoaeueieo
oeyo?a, o oiio /ene? ? aei aeeooa???. ?ic?iaeai? iieacaiiy ? aecia/ai?
aeice oa o?eaae?noue i?eeiio aiaeii-nie?oiaiai aeno?aeoo ao?iaoea?
io?io?iai?. Cai?iiiiiaaia ?aaa?e?oaoe?eia oa?ai?y ai?iaaaeaeaia a
iaeani?e ee?i?/i?e e?ea?i? i.Iieoaae, i?nuee?e ee?i?/i?e ?ioaeoe?ei?e
e?ea?i? i.Iieoaae, aeeoy/?e i?nuee?e ee?i?/i?e e?ea?i? i.Iieoaae,
naiaoi??? «Aa?aciaee aae» i.Ie?iai?iaea.

Ni?eueii c IAe? oa?iaeieia?? ? oieneeieia?? AII Oe?a?ie ?ic?iaeaia
ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia aiaeii-nie?oiaee aeno?aeo
ao?iaoea? io?io?iai? (OON 42O-13/18688-98 ), i?iieneiaee aeione yeiai
?icii/aoi ia AAO «Eoaieoa?i».

?ic?iaeaia ?aoeaioo?a ? ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia oa?/ia?
i?iaeoeoe c aeeth/aiiyi aeno?aeoo ao?iaoea? io?io?iai?, ui cai?iiiiiaai?
aeey aei?ineeo ? ae?oae, ye? ciaoiaeyoueny a oiiaao ae?? iani?eyoeeaeo
aeieia?/ieo oaeoi??a oa i?ioan?eieo oe?aeeeainoae (iaoaio Oe?a?ie
?24300A). I?iieneiaee aeione «E?eoaaeueii-i?io?eaeoe/iiai i?iaeoeoo»
ai?iaaaeaeaii ia caaiae? aeeoy/iai oa?/oaaiiy ?i.1 O?aaiy,
i.N?ioa?iiieue.

Iniiai? iieiaeaiiy aeena?oaoe?eii? ?iaioe aeei?enoiaothoueny o
iaa/aeueiiio i?ioean? i?e aeeeaaeaii? ?ioaeoe?eieo oai?ia, a?io?i??,
ee?i?/ii? oa?iaeieia??, iaoieia?/ii? aiaoii?? a Oe?a?inuee?e iaaee/i?e
noiiaoieia?/i?e aeaaeai??, A?iieoeueeiio iaaee/iiio oi?aa?neoao?,
Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai??, Iaeanueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? oa Oa?e?anueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao?.

Iniaenoee aianie caeiaoaa/a o ?ic?iaeo iaoeiaeo ?acoeueoao?a, ui
aeiinyoueny ia caoeno. Aaoi?ii aeena?oaoe?eii? ?iaioe iniaenoi
?ic?iaeai? i?ia?aia ? iaoiaeieia?y aeine?aeaeaiiy. Naiino?eii i?iaaaeai?
aenia?eiaioaeuei? oa ee?i?/i? aeine?aeaeaiiy, aeeiiaia a?eueo?noue
a?io?i?/ieo, a?io?ce/ieo, eiaaoeieia?/ieo oa ?ioiieia?/ieo iaoiae?a.
I?iaaaeaia noaoenoe/ia ia?iaea ? aiae?c ia?aeiiiai iaoa??aeo, iaienai?
an? ?icae?ee ?iaioe, noi?ioeueiaai? aeniiaee oa i?aeoe/i?
?aeiiaiaeaoe??. *anoeia ?acoeueoao?a aenia?eiaioaeueieo ? ee?i?/ieo
aeine?aeaeaiue aoea io?eiaia ni?eueii c e.i.i.I.I.?cthinueeith.

O?aaiaio aeena?oaoe?eii? ?iaioe aeeiiaiee o ?aieao eiieo?nii?
iaoeiai-aeine?aeii? ?iaioe 1993 ?. «Aea/aiiy ?ie? aca?iica’yceo
a?eueii?aaeeeaeueieo, aaiieiaaoethth/eo, ?ioiieo iaoai?ci?a o iaoiaaiac?
caoai?thaaiue, iia’ycaieo c ae??th i?aeaeuaieo aeic ?ii?coth/iai
aei?ii?ithaaiiy, oa ?ic?iaea iaoiae?a ?o iaoiaaiaoe/ii? ei?aeoe??
iaia?aiinoaa?e?coth/eie oa iie?iaioeaeieie i?aia?aoaie» (? aea?ae.
?a?no?aoe?? 0193V024034).

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe?eii? ?iaioe
aoee aeeeaaeai? oa iaaiai?ai? ia ? Oe?a?inuee?e eiioa?aioe?? «Ia?iaeiay
e iao?aaeeoeeiiiay iaaeeoeeia e iooe a? ?acaeoey» (Iieoaaa, 1993),
?aae?ia?ieia?/iiio c’?cae? (Ee?a, 1993), ? Iaoe?iiaeueiiio c’?cae?
oa?iaeieia?a Oe?a?ie «No/ani? i?iaeaie oa?iaeieia??» (Iieoaaa, 1995),
iaeanieo iaoeiaeo eiioa?aioe?yo «Aeooaeuei? ieoaiiy oai?aoe/ii? oa
ee?i?/ii? iaaeeoeeie» (1995, 1996 ??.), iaeani?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? (Iieoaaa, 1997), I?aeia?iaei?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? «Eco/aiea e eniieueciaaiea yoeiaoeae» (Iieoaaa,1998 ), V
c’?cae? ?ioaeoe?ii?no?a Oe?a?ie «Aeooaeuei? ieoaiiy ee?i?/ii?
?ioaeoieia??» (Oa?iii?eue, 1998), iaoeiai-i?aeoe/i?e eiioa?aioe?? ?
ieaioi? Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie (i.Eooeuee, 1999), ia
i?aenoieiaeo ui??/ieo iaoeiaeo eiioa?aioe?yo OINA (1992-1997 ??.).

Ioae?eaoe??. Ca oaiith aeena?oaoe?eii? ?iaioe iaae?oeiaaii 34 iaoeia?
?iaioe, c yeeo 18 noaoae (naiino?eieo – 7 ) ? 16 oac aeiiia?aeae
(naiino?eieo – 6), io?eiaii 5 iaoaio?a Oe?a?ie. 16 noaoae iioae?eiaaii
o oaoiaeo aeaeaiiyo.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, ?icae?eo caaaeueiiee?i?/ii? oa?aeoa?enoeee ianoaaeaieo a?oi
oai?eo ? caei?iaeo ethaeae, iaoa??ae?a ? iaoiae?a aeine?aeaeaiiy, 5
?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae. ?iaioa aeeeaaeaia ia 404
noi??ieao, i?noeoue 48 ?enoie?a, 118 oaaeeoeue, ui caeiathoue 62 ie?aieo
noi??iee. A?ae?ia?ao?y i?noeoue 411 iaeiaioaaiue ? caeia? 40 noi??iie.

Ci?no ?iaioe

Caaaeueia oa?aeoa?enoeea ianoaaeaieo a?oi oai?eo ? caei?iaeo ethaeae.
Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

Aeey ?aae?caoe?? iaoe ? caaaeaiiy aeine?aeaeaiiy iaie ianoaaeaii 475
in?a: 133 oai?eo ia aeeooa??th, 64 iin?? C.d., 112 in?a, ye? iaee
i?aeaeuaio ni?eeiyoeea?noue aei ?ioaeoe?e aeeoaeueieo oeyo?a oa 166
i?aeoe/ii caei?iaeo.

Na?aae ianoaaeaieo oai?eo ia aeeooa??th ae?iie aoei 75, /ieia?e?a – 58;
iieiaeiai a?eo – 111, na?aaeiueiai – 18, iioeeiai – 4. Ia?aa?a aeeooa???
aiae?coaaee caeaaeii a?ae ee?i?/ii? oi?ie, oyaeeino? oa iayaiino?
oneeaaeiaiue. I?e oeueiio ianoaaeaieo c eieae?ciaaieie oi?iaie aoei 100,
iioe?aieie – 14, eiia?iiaaieie – 18. Eaaeee ia?aa?a iaa i?noea o 30,
na?aaeiueioyaeeee – o 90, oyaeeee – o 13 oai?eo. Oa?aeoa?i? aeey
aeeooa??? oneeaaeiaiiy ?icaeioeeny o 42 ianoaaeaieo, ?c ieo: o 41
ae?aaiinooaaee i?iea?aeeo, o 11 – o?aaeaiiy ia?aiai? nenoaie ? o 11 –
ie?ie. Iaoe??io?a c oneeaaeiaiiyie, o yeeo ?icaeioany eeoa i?iea?aeeo,
aoei 30, o ?ioeo aecia/aeeny iiiaeeii? oneeaaeiaiiy caoai?thaaiiy. Ca
nooiaiai oyaeeino? i?iea?aeeoo oai?? ?iciiae?eeeeny oae: eaaeee – 8,
na?aaeiueioyaeeee – 21, oyaeeee – 12 in?a.

Iin?enoai C.d. ?a?no?oaaee o 33 /ieia?e?a ? 21 ae?iee: 41 – iieiaeiai,
12 – na?aaeiueiai ? 1 – iioeeiai a?eo. Na?aae iin??a C.d. 28 aeae?eyee
oieneaaii? ooaie caoaeieea ? 36 – iaoieneaaii?; o 29 iin?enoai C.d.
?icaeioeiny ia oii? o?ii?/iiai oiicee?oo. 10 iin??a C.d. ?c noiooi?i
o?ii?/iei oiicee?oii ia oii? caaaeueiiaeciaii? aioeaaeoa??aeueii?
oa?ai?? io?eiaee aiaeii-nie?oiaee aeno?aeo ao?iaoea? io?io?iai?. C
iaoith ii??aiyiiy iieaciee?a, ye? aecia/aee o oai?eo ia aeeooa??th oa
iin??a C.d., ianoaaeeee 56 i?aeoe/ii caei?iaeo (aeiii?e).

A?oio in?a c o?ii?/iith iaoieia??th EI?-i?aai?a, o yeeo aecia/aany
iecueeei ??aaiue ?acenoaioiino?, neeaee 12 nooaeaio?a (7 /ieia?e?a ? 5
ae?iie iieiaeiai a?eo) c o?ii?/iei oiicee?oii aac ee?i?ei-ia?aee?i?/ieo
iciae ?ioi? niiaoe/ii? iaoieia??; a oaeiae a?enueeiaineoaeaiaoe?, ye?
acyee o/anoue o e?ea?aeaoe?? iane?aee?a aaa??? ia *AAN o /a?ai?–na?ii?
1986 ?. (100 /ieia?e?a iieiaeiai a?eo). ?acoeueoaoe aeine?aeaeaiiy oeeo
a?oi ii??aithaaee c aeaieie, io?eiaieie i?e ianoaaeaii? caei?iaeo c
aenieei ??aiai ?acenoaioiino? (32 nooaeaioe oa 50 aeiii??a).

12 in?a c iecueeei ??aiai ?acenoaioiino? (o/anieee e?ea?aeaoe??
iane?aee?a aaa??? ia *AAN) io?eiaee eo?n ?aaa?e?oaoe?eii? oa?ai??
aeno?aeoii ao?iaoea? io?io?iai? i?ioyaii 3 oeaei?a. Aoaeoeai?noue
i?iaaaeaiiai e?eoaaiiy ioe?ithaaee i?e ii??aiyii? c iieacieeaie
aiaeia?/ii? a?oie iaoe??io?a (18 /ieia?e?a), yeeo e?eoaaee oeiae?iii
i?ioyaii 10 ae?a.

Ee?i?/io aoaeoeai?noue aeno?aeoo ao?iaoea? io?io?iai? aecia/aee oaeiae o
in?a c o?ii?/iei oiicee?oii (28 /ieia?e?a iieiaeiai a?eo).

Aeey anoaiiaeaiiy ae?aaiico «aeeooa??y» a?aoiaoaaee ee?i?/i? aeai?
(ae?aaeai?noue neiioii?a oa ?o aeeiai?eo, no?iee aeieeiaiiy ? oa?aeoa?
oneeaaeiaiue, aoaeo a?ae e?eoaaiiy oa ?i.), ?acoeueoaoe
ai?aeai?ieia?/iiai, aaeoa??ieia?/iiai oa na?ieia?/ieo aeine?aeaeaiue.
Ca?aeii c eeaneo?eaoe??th, iaaaaeaiith o aeaeaii? “Iaaeaeoia?iaeiay
eeanneoeeaoeey aieaciae” (AIC, 1985), aeeooa??th ioe?ithaaee ca
eieae?caoe??th, iioe?ai?noth i?noeaaiai caiaeueiiai i?ioeano, oa?aeoa?ii
o?aaeaiiy neeciai? iaieiiee oa oyaee?noth ia?aa?ao. Aeey anoaiiaeaiiy
ae?aaiico «aeeooa??eiee i?iea?aeeo» oa aecia/aiiy nooiaiy eiai oyaeeino?
aeei?enoiaoaaee aeai?, aeeeaaeai? o iaoiaee/ieo ?aeiiaiaeaoe?yo
“Eeeieea, aeeaaiinoeea aeeooa?eeiuo ieiea?aeeoia e i?eioeeiu eo ea/aiey”
(AE.E.Aiceaiiaa e niaao., 1993; AE.E.Aiceaiiaa, 1996). Ae?aaiic
aaeoa??iiin?enoaa anoaiiaethaaee ca a?aenooiino? ee?i?/ieo i?iya?a
aeeooa???, ci?i ia AEA o i?ioean? iaaeyaeo oa ca iayaiino? uaieaiue
(N.I.E?aia??a ? ni?aaao., 1996).

I?e aecia/aii? ??aiy ?acenoaioiino? aeei?enoiaoaaee i?ae?aooiie aino?eo
caoai?thaaiue aeeoaeueieo oeyo?a i?ioyaii 1 ?ieo aeeooy: aenieee
??aaiue aecia/aee ca ?oiuei? a?aenooiino?, iecueeee – ca iayaiino?
/anoeo (4 ? a?eueoa) aino?eo caoai?thaaiue (A.A.Aeineei, I.I.?aoiaiiaa,
1993; A.I.Ae?aiiee e niaao., 1994).

Oai?ei ia aeeooa??th aeine?aeaeaiiy i?iaiaeeee o aeeiai?oe?: i?e
aini?oae?caoe??, eiaei? 5-7 aei?a ia?aaoaaiiy o noaoe?iia?? oa i?e
aeienoe?. 14 oai?ei, ye? ia?aianee aeeooa??eiee i?iea?aeeo,
ee?i?ei-a?io?i?/ia ianoaaeaiiy aeeiiaia /a?ac 6 i?nyoe?a i?ney aeienee.
Iin?yi C.d. aeine?aeaeaiiy aeeiioaaee aeai?aciai: aei ? i?ney
i?iaaaeaiiy naiaoe??. Iniaai c iecueeei ??aiai ?acenoaioiino?, ye?
io?eiaee eo?ne ?aaa?e?oaoe?eii? oa?ai??, aeine?aeaeaiiy aeeiiai? aei ?
i?ney caaa?oaiiy eo?n?a e?eoaaiiy.

Aeey ae??oaiiy iinoaaeaieo caaaeaiue iniiaieie o ianoaaeaii? oai?eo ?
caei?iaeo ethaeae, a oaeiae aenia?eiaioaeueieo oaa?ei, aoee a?io?i?/i?
oa a?io?ce/i? iaoiaee, ca aeiiiiiaith yeeo ioe?ithaaee e?i?aeiee iai?i,
?ioaineai?noue ?aaeoe?e a?eueii?aaeeeaeueiiai IIE oa noai AIN.
Oa?oioaaiiy aeei?enoaieo a?io?i?/ieo ? a?io?ce/ieo iaoiae?a iaaaaeaia o
oaae. 1.

Noai i?noeaaiai ?ioi?oaoo ioe?ithaaee ca eiioeaio?aoe??th sIgA
(A.A.*a?iioainoiaa e niaao., 1975) o neei? ianoaaeaieo iaoe??io?a.
Ioe?ieo ee?oeiiiai ?ioi?oaoo i?iaiaeeee ca iaoiaeii E.A. Eaaaae?aa oa
?.Ae.Iiiye?ii? (1990), aoii?aeueiiai – ca eiioeaio?aoe??th
?ioiiaeiaoe?i?a A, I ? G o ne?iaaooe? (G.Mancini et al., 1965). Ai?no
Oe?E o ne?iaaooe? aecia/aee i?aoeei?oaoe??th o ?ic/ei?
iie?aoeeaiae?eieth (V.Haskova et al., 1977); eiiieaiaioa?io aeoeai?noue
ne?iaaoee – ca 50% aaiie?cii (I.A.Aycia, I.O.Oiaeaeaaaa, 1973);
oaaioeeoa?io aeoeai?noue iie?ii?oiiyaea?ieo iaeo?io?e?a (IssH) – o
?aaeoe?? c i?o?inei?i oao?acie??i (INO-oano) (TH.E.Aaaei?a e niaao.,
1981), noai i?e?ioee?eoeyoi?iiai oa eiaaoeyoe?eiiai aaiinoaco – ca
iieacieeaie aa?aaaoia?aie (G.V.R.Born, 1962) oa noaiaea?oieie
iaoiaeeeaie (A.I.Aaeoaea e niaao., 1980).

Aenia?eiaioaeuei? aeine?aeaeaiiy i?iaaaeai? ia 91 noaoaaic??eiio e?ieeeo
ii?iaee oeioeea, 108 noaoaaic??eeo uo?ao e?i?? A?noa?, 18 noaoaaic??eeo
a?eeo ieoao e?i?? BALB, 71 ii?nuee?e naeioe?.

Aeeooa??eio ?ioieneeaoe?th iiaeaethaaee oeyoii iaeii?aciaiai
aioo??oiueii/a?aaeiiiai aaaaeaiiy 0,3 DLM aeeooa??eiiai oieneio ia 1 ea
aaae oaa?eie (E.A.Oaai?iaa e niaao., 1988). Oaa?ei aeaiaeeee c aeine?aeo
ia 4, 7 oa 15 aeiao. *anoeia oaa?ei ia oii? aaaaeaiiy aeeooa??eiiai
oieneio io?eioaaea aiienei?i aioo??oiueii/a?aaeiii c ?ic?aooieo 1,0
ia/ea iane i?ioyaii 5 ae?a.

O iiaeaeueieo, aino?eo oa o?ii?/ieo aeine?aeao c’ynoaaee
ia?niaeoeai?noue aeei?enoaiiy aiaeii-nie?oiaiai aeno?aeoo ao?iaoea?
io?io?iai? i?e noaiao, ui oi?iothoueny aiane?aeie ae?? iani?eyoeeaeo
aeieia?/ieo oaeoi??a. O ?iaio? aoee aeei?enoai? oae? iiaeae?:
i?iiaiaaiai ooeiaeaeaiiy (iaeii?aciaa oioaeueia -ii?ii?iaiiy a?ae
aeaea?aea Ni60 o aeic? 5 A?); o?ii?/ii? aioeieneaeaioii? iaaeinoaoiino?
(I.I.Aine?anainueeee oa ni?aaao., 1983); aino?iai caiaeaiiy (O.I.O?eion
e niaao., 1983).

O iiaeaeueieo aeine?aeao aecia/aee i?i?iaeueio ae?th/o aeico
aiaeii-nie?oiaeo aeno?aeo?a ao?iaoea? io?io?iai? ye ?ia?a?oi??a
a?eueii?aaeeeaeueiiai IIE o ?aaeoe?? oa?i?/iiai aaoiieeneaiiy ieaaoo a
i?enooiino? aiiiaaiaoo ia/?iee ? aeine?aeaeoaaieo aeno?aeo?a
(A.A.Ia?aie/ e niaao., 1992).

Io?eiai? aeai? i?aeaeaaaee aa??aoe?eiiio noaoenoe/iiio aiae?co c
aeei?enoaiiyi ia?aiao?e/iiai t-e?eoa??th Nouethaeaioa. Aeey
iai??eiaoaaiiy ca’ycaiino? ci?i ia?aiao??a canoiniaoaaee ei?aeyoe?eiee
aiae?c. Ia/eneaiiy i?iaiaeeee ia IAII IBM PC Pentium II c aeei?enoaiiyi
i?ia?aie «Statistica for Windows. Release 4.3» (Statsoft). I?e iaeyae?
e?oa?aoo?e aeei?enoiaoaaee aaiee aeaieo nenoai «Medline» oa «Current
Contents».

Oaaeeoey 1

A?io?i?/i? ? a?io?ce/i? iaoiaee aeine?aeaeaiiy

IieacieeIaoa??aeE?oa?aoo?aCaaaeuei? e?i?aeene?iaaoea»Aeioano», Lachema,
Neiaa//eiaCaaaeueiee oieanoa?eioa ae»Aeioano», Lachema, Neiaa//eia- ?
i?a—e?iii?ioa?aee-«-A.I.Eeeiia oa ni?aaao.,
1966Aoeeea?ae?iia?aeene-«-I.I.Aine?anainueeee, A.A.Ooiaiia, 1982Ae??iia?
eii’thaaoe (AeE), o?e?iia? eii’th-aaoe (OE), ieniae??iia? eii’thaaoe
(IAeE), oao?a?iee?ia, ia/?iea, naeac?iea, i?iea?ae, ie?ee,
iaaeie?ieeeA.A.Ia?ai?/ ? ni?aaao., 1992OAE-?aaaaioeoa
aeTH.A.Aeaaeeie?ia, A.E.A?/aeia, 1972E?iii?aiaioe-”-B.L.Fletcher,
A.L.Tappel, 1973Ia?aeeniee aaiie?c a?eo?ioeeo?ae?iaF. Jager,
1968Eeneioia ?acenoaioi?noue a?eo?ioeeo?aoa aeE.A.Oa?neia,
E.E.Aeoaeuecii, 1957-oieioa?ie (OO, OOO, IOO)e?ia, ia/?iea, naeac?iea,
i?iea?ae,ie?ee, iaaeie?eiaeeeI.I.A?eai?’?aa (1984) o iiaeeo?eaoe??
A.A.Ia?ai?/a oa ni?aaao., 1992?aoeiie ? -ea?ioeioa aeI.I.A?eai?’?aa
(1984) o iiaeeo?eaoe?? A.A.Ia?ai?/a oa ni?aaao., 1992Anei?a?iiaa
eeneioa-«-O.O.Oa?iaiia, 1976Caaaeueia aioeieenethaaeueia aeoeai?noue
(AIA)-”-A.A.Ia?ai?/, 1996Oea?oeiieaci?i (OeI)ne?iaaoeaI.A.Neaa?eia ?
ni?aaao., 1986Noia?ieneaeaeeniooaca (NIAe )e?ia, ia/?iea, naeac?iea,
i?iea?ae, ie?ee, iaaeie?eiaeeeI.N.A?onia ? ni?aaao.,
1976Eaoaeacae?iaI.I.Iooe?ia,1963?iaeoeiaaia oai?ethi?ianoeaioe?y
ne?iaaoeaA.A.Aa?aaie ? ni?aaao., 1983Noai a?eueii?aaeeeaeueiiai
ia?aeeniiai ieeneaiiy e?i?ae?a ? iieacieee aioeieneaeaioii? nenoaie ca
oiia aenia?eiaioaeueii? aeeooa??eii? ?ioieneeaoe??

Aenia?eiaioaeuei? aeine?aeaeaiiy iieacaee, ui ca oiia aeeooa??eii?
?ioieneeaoe?? ii?ooo?oueny iaoaaie?ci iie?iaiane/aieo aee?ieo eeneio
(IIAEE), aeoeaothoueny ?aaeoe?? a?eueii?aaeeeaeueiiai IIE oa iathoue
i?noea ii?ooaiiy o AIN. Cacia/ai? ci?ie o oeaieiao ??cieo i?aai?a
nooo?ai a?ae??ciyeeny (?en.1). Iaeneiaeueia aeoeaaoe?y IIE, yea
?a?no?oaaeany i?ioyaii onueiai oa?i?io aeine?aeaeaiiy, niinoa??aaeany o
i?iea?ae? oa naeac?ioe?. O ie?eao aecia/aeany ei?ioei/ania aeoeaaoe?y
IIE ? ia 15-oo aeiao a?aeiiaethaaany ??aaiue IIE, oa?aeoa?iee aeey
?ioaeoieo oaa?ei. O ia/?ioe? aeoeaaoe?y i?ioean?a e?iiia?ieneaeaoe??
niinoa??aaeany o?eueee ia 4-oo aeiao, a o iaaeie?eiaeeao iaea i?noea
ae?aaeaia oaiaeaioe?y aei aeoeaaoe?? IIE i?ioyaii onueiai oa?i?io
aeine?aeo. Ci?ie iieaciee?a ieacie oaeiae na?ae/eee i?i aeoeaaoe?th IIE,
aea ia 7-io aeiao eiioeaio?aoe?y IAeA, ia a?aei?io a?ae oeaiei
aeine?aeaeaieo i?aai?a, ??cei ciaioeeanue, ui iiaea aooe iia’ycaia c
i?aeaeuaiei ai?noii OAE-?aaeoaio?a o oeaieiao oa c aeniaaeaiiyi
noano?aoo IIE. Oaeei /eiii, ca nooiaiai aeoeaaoe?? ?aaeoe?e
e?iiia?ieneaeaoe?? oeaieie aeine?aeaeaieo i?aai?a ?iciiae?eeeeny oae:
i?iea?ae naeac?iea ie?ee iaaeie?eiaeee ia/?iea.

?ioaineai?noue IIE ?aaeaiaioo?oueny AIN. Ia ii/aoeiaeo aoaiao
aeeooa??eii? ?ioieneeaoe?? (4-a aeiaa) o e?ia? oa oeaieiao
aeine?aeaeaieo i?aai?a a?aei?/aeany iia?e?caoe?y ?aca?a?a AIN,
ni?yiiaaia ia caa?aaeaiiy iaoaaie?cio IIAEE oeyoii neioaco aoii?aeueii
aeoeaieo niieoe ? i?aeo?eieo IIE ia ??ai?, oa?aeoa?iiio aeey ?ioaeoieo
oaa?ei. I?e oeueiio iaea?eueo ae?aaeaio iia?e?caoe?th ?aca?a?a AIN
niinoa??aaee o oeaieiao i?iea?aeo, naeac?iee oa iaaeie?eiaee?a. Ia 7-o
aeiao aeine?aeo ci?ie iieaciee?a AIN o oeaieiao ??cieo i?aai?a iaee
nooo?a? a?aei?iiino?: o i?iea?ae? oa naeac?ioe? ?a?no?oaaeiny ??cea
cieaeaiiy ai?noo oa aeenaaeain o nenoai? aee?i?ic/eiieo a?oai?i?a oa
oa?iaio?a; o iaaeie?eiaeeao a?aei?/aeiny ae?aaeaia iai?oaeaiiy o
nenoai?, yea ia?aaeaa/a? iiaeeeaa aeniaaeaiiy ?aca?aieo iiaeeeainoae
inoaiiuei? i?e ae?? aeiaeaoeiaeo /eiiee?a; o ia/?ioe? oa ie?eao
??aiiaaaa o AIN a oeae ia??iae a?aeiiaethaaeanue. Ia 15-o aeiao
niinoa??aaeany oaiaeaioe?y aei a?aeiiaeaiiy ooieoe?iiaeueii? aeoeaiino?
AIN o oeaieiao i?iea?aeo, naeac?iee oa iaaeie?eiaee?a. Iaea?eueo
no?eeeie ii?ooaiiy aioeieenethaaeueiiai aiiainoaco aeyaeeeny o
i?iea?ae?.

Ci?ie o nenoai? IIE–AIN ca oiia aeeooa??eii? oienai?? iia’ycai?, ia iao
iiaeyae, ia?o ca ana c ae??th aeeooa??eiiai oieneio, yeee caeaoiee
eiieo?oaaoe c aeeoaeueieie oa?iaioaie ee?oei (oeeoio?iiaie) oa
i?eai?/oaaoe neioac a?eea (E.A.Oaai?iaa e niaao., 1988), ui, a naith
/a?ao, ni?ey? ?i?oe?aoe?? IIE oa cieaeo? ooieoe?iiaeueio aeoeai?noue
oa?iaioaoeaii? ? iaoa?iaioaoeaii? eaiie AIN.

I?eaa?oa? oaaao oie oaeo, ui iaeneiaeueii ae?aaeaio aeoeaaoe?th IIE ?
ii?ooaiiy o AIN niinoa??aaeeny o oeaieiao oeo i?aai?a, ye? iathoue
aenieo /ooeea?noue aei ae?? aeeooa??eiiai oieneio, ui aeicaiey?
i?eionoeoe ?ieue a?eueii?aaeeeaeueieo iaoai?ci?a o iaoiaaiac? ?o
ooeiaeaeaiiy, cie?aia o ?icaeoeo aeeooa??eiiai i?iea?aeeoo. I?iaaaeai?
iaie ii?oieia?/i? aeine?aeaeaiiy i?aeoaa?aeeee ?icaeoie i?iea?aeeoo ca
oiia i?iaaaeaiiai aeine?aeo ? aeiaaee aca?iica’ycie ooeiaeaeaiue
ea?ae?ii?ioeeo?a, ia?aiaeo aieieii, noaeei oa no?iie c aeoeaaoe??th
?aaeoe?e a?eueii?aaeeeaeueiiai IIE (I.I.?cthinueea ? ni?aaao., 1997).
Ne?ae cacia/eoe, ui iaeiie/aiiy aeueaeaa?aeieo niieoe, ooai?aieo o
i?ioean? ?aaeoe?e IIE, ni?ey? oaeiae ?icaeoeo aoeeaeico, ui iiaeeaeth?
a?iien?th oa iiaea i?ecaanoe aei iae?ico ea?ae?ii?ioeeo?a (O.C.Iaa?nii,
1988).

A?aeiii, ui nenoaia a?iaioeieneaeaio?a (AAI), ia?o ca ana aee?i?ic/eiieo
a?oai?i?a OO, ?aoeiieo, ?-ea?ioeio a oiiaao aeno?aiaeueiiai aieeao ia
i?aai?ci aa?a aeoeaio o/anoue o caa?aaeaii? aioeieenethaaeueiiai
aiiainoaco (A.I.Eacia/aaa, 1980; AE.E.Aa?aiiaa, A.E.Ienaiaaiaeea?, 1985;
E.E.Aaeyaa e niaao., 1992; I.I.Aine?anaineee, A.I.Aiau?aa, 1992 oa
?io?), ui i?aeoaa?aeaeo?oueny i?iaaaeaieie iaie aeine?aeaeaiiyie ia
iiaeae? aeeooa??eii? ?ioieneeaoe??. Caeiiii??iei aeey aeeooa??eii?
?ioieneeaoe?? aeyaeeiny ciaioaiiy ai?noo OO oa ?aoeiieo ia 7-o aeiao
aenia?eiaioo, ianaiia?aae o i?ie?aae? oa naeac?ioe?, ui iiaea aooe
iaoiiaeaia ?o iineeaiith aeo?aoith o ca’yceo c iaeneiaeueii ae?aaeaiith
aeoeaaoe??th IIE o oeaieiao naia oeeo i?aai?a. Iaaeinoaoi?noue OO ?
?aoeiieo, a naith /a?ao, iiaea iaaaoeaii aieeiooe ia
no?oeoo?ii-ooieoe?iiaeueio iiaiioe?ii?noue ee?oei ? iaaaoeaii
iicia/eoeny ia i?ioeanao ?aia?aoeaii? ?aaaia?aoe?? (AE.E.Aa?aiiaa,
A.E.Ienaiaaiaeea?, 1985; A.A.Nie?e/aa, E.ss.Eiiue, 1989). Ia i?aenoaa?
aiae?co aeaieo e?oa?aoo?e, a oaeiae ?acoeueoao?a i?iaaaeaieo
aeine?aeaeaiue, o/anoue a?eueii?aaeeeaeueieo iaoai?ci?a a ooeiaeaeaii?
ea?ae?ii?ioeeo?a iiaeia i?aaenoaaeoe o aeaeyae? noaie (?en. 2).

Iaaei??ia aeoeaaoe?y IIE ?c iaeiie/aiiyi ia?aeiieo ? aoi?eiieo
i?iaeoeo?a e?iiia?ieneaeaoe?? o naeac?ioe?, yea ii?oiooieoe?iiaeueii
nii??aeiaia c oeaieiaie ?ioeo ?ioiieiiiaoaioieo i?aai?a, aeicaiey?
i?eionoeoe o/anoue a?eueii?aaeeeaeueieo iaoai?ci?a o iaoiaaiac?
?ioiiaeai?an??, oa?aeoa?ii? aeey aeeooa??eii? ?ioaeoe??.

Aeey iaa?oiooaaiiy iieiaeaiiy i?i oa, ui aeoeaaoe?y IIE ? ae??oaeueiith
eaieith iaoiaaiaco ooeiaeaeaiue, iaiao?aeii aeiaanoe, ui AI a oaeeo
naieo oiiaao aeine?aeo aoaeooue aeyaeyoe i?ioaeoi?io ae?th. O
i?iaaaeaiiio iaie aeine?aeaeaii? aoa aeei?enoaiee aiienei?i –
neioaoe/iee aiaei?ic/eiiee i?yiee AI, yeee ia? eiiieaenio ae?th: ?
iaia?aiii?ioaeoi?ii, ?ioiiiiaeoeyoi?ii, ii?iae?co? i?e?ioee?eoeyoi?iee
aaiinoac, ciaioo? i?iieei?noue noaeei, caiia?aa? ?icaeoeo AeAC e?ia?
(A.A.Oaaaeiaa e niaao.; 1986) ? iei? canoiniao?oueny o ee?i?/i?e
i?aeoeoe? ye ea?ae?ii?ioaeoi?.

?en. 2. O/anoue a?eueii?aaeeeaeueieo iaoai?ci?a a ooeiaeaeaii? i?iea?aea
i?e aeeooa??ei?e oienai??.

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui aaaaeaiiy aiienei?io aeyaeei
iaeneiaeueii ae?aaeaiee i?ioaeoi?iee aoaeo o oeaieiao oeo i?aai?a, o
yeeo niinoa??aaee iaaei??io aeoeaaoe?th IIE, ui oaeiae ? aeieacii o/ano?
a?eueii?aaeeeaeueieo i?ioean?a o iaoiaaiac? aeeooa??eii? oienai??. O
ia?oo /a?ao i?aia?ao aeyaea ae?aaeaio ea?ae?ii?ioaeoi?io aeoeai?noue:
i?e eiai canoinoaaii? ciaioeeiny ooai?aiiy aoi?eiieo ? e?ioeaaeo
i?iaeoeo?a IIE oa iaaaioaaeaiiy ia AIN ia 4-o aeiao oa ia niinoa??aaeiny
iaaei??ii? aeoeaaoe?? IIE ? aeniaaeaiiy oa?iaioaoeaieo ?
iaoa?iaioaoeaieo AI ia 7-o aeiao. Aaaaeaiiy aiienei?io ni?eyei oaeiae
caa?aaeaiith ooieoe?iiaeueii? aeoeaiino? oa?iaioaoeaii? ?
iaoa?iaioaoeaii? eaiie AIN o oeaieiao ?ioeo i?aai?a. Caeiiii??iei
aeyaeeiny c?inoaiiy i?ae aieeaii i?aia?aoo ai?noo aee?i?ic/eiieo
a?oai?i?a ia 15-o aeiao aeine?aeo, ui iiaea na?ae/eoe i?i noeioeyoe?th
i?ioean?a ?aia?aoeaii? ?aaaia?aoe??, aeey yeeo, ye a?aeiii, iaiao?aeiee
i?aeaeuaiee ??aaiue aioeieneaeaioii? caaacia/aiino? (A.A.Ao?eaeiaa,
1975).

Caoeniee aoaeo aiienei?io iaoiiaeaiee ia?o ca ana i?yiith
aioe?aaeeeaeueiith ae??th, caaaeyee /iio i?aia?ao ??cei iaiaaeo?
?ioaineai?noue IIE ? caiia?aa? ooeiaeaeoaaeueiei aoaeoai IIE ? e?i?aeii?
o??aaee a oe?eiio (O.C.Iaa?nii, 1988). Aeei?enoaiiy aiienei?io a
neooaoe?yo e?eoe/ieo noai?a i?eaaaeeaa oaeiae o ca’yceo c a?aenooi?noth
iia?/ieo aoaeo?a, a oaeiae c iayai?noth o i?aia?aoo eiiieaenii? ae??, ia
ui aeacoaaeiny aeua.

Oaeei /eiii, i?iaaaeai? aenia?eiaioaeuei? aeine?aeaeaiiy aeiaaee, ui o
iaoiaaiac? aeeooa??eii? oienai?? cia/ia ?ieue iaeaaeeoue ii?ooaiiyi AIN
oa iaaei??i?e aeoeaaoe?? IIE, ? iieacaee, ui ?c cacia/aieie ii?ooaiiyie
iiaeooue aooe iia’ycai? oneeaaeiaiiy aeeooa???. Oeae aeniiaie
i?aeoaa?aeaeoaaany ?acoeueoaoaie ee?i?/ieo niinoa?aaeaiue ? a?io?i?/ieo
aeine?aeaeaiue, ye? aeaoaeueii iienai? aeae?.

Iaoaaie?/i? ci?ie o oai?eo ia aeeooa??th

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui ci?ie iieaciee?a IIE oa AIN o
oai?eo ia aeeooa??th ciaoiaeeeeny o caeaaeiino? a?ae oyaeeino? ia?aa?ao,
iayaiino? oneeaaeiaiue oa iioe?aiino? i?noeaaiai caiaeueiiai i?ioeano.
Oae, i?e eaaeiio ia?aa?ao a ia??iae? ?iciaeo oai?iae iaei i?noea
cieaeaiiy aeoeaiino? oa?iaio?a AIN, yea noi?iaiaeaeoaaeiny i?aeaeuaiiyi
eiioeaio?aoe?? OeI ia 1-o oeaei? oai?iae; o ia??iae? ?aeiiaaeanoeaioe??
aeoeai?noue NIAe a?aeiiaethaaeanue, a aeoeai?noue eaoaeace caeeoaeany
ieae/ith ii??aiyii c a?oiith caei?iaeo ethaeae. Ai?no AeE oa IAeA o
ia??iae? ?iciaeo oai?iae i?e eaaeiio ia?aa?ao oo?eioaaeeny ia ??ai?
iieaciee?a caei?iaeo, aea o ia??iae? ?aeiiaaeanoeaioe?? c’yaeeany
oaiaeaioe?y aei ?o c?inoaiiy. I?e na?aaeiueioyaeeiio ia?aa?ao
aeoeai?noue eaoaeace ? NIAe o ia??iae? ?iciaeo ci?ithaaeanue aiaeia?/ii
eaaeiio, aea, ii/eiath/e c 2-ai oeaeiy, a?aei?/aeany aeoeaaoe?y IIE ?
iieacieee IAeA oo?eioaaeeny i?aeaeuaieie ? i?e aeienoe? c? noaoe?iia?o.
sse iieacaa ei?aeyoe?eiee aiae?c, ?c i?aeaeuaiiyi ai?noo i?iaeoeo?a
e?iiia?ieneaeaoe?? o oai?eo ?c ia?aa?aii aeeooa??? na?aaeiuei? oyaeeino?
ca?aaeany iiyaa ee?i?ei-eaai?aoi?ieo iciae i?iea?aeeoo. I?e oyaeeiio
ia?aa?ao aeeooa??? o ia??iae? ?iciaeo iieacieee IIE ci?ithaaeeny o aeaio
iai?yieao: o a?eueoino? oai?eo – i?aeaeuoaaeeny, a o iaioi? /anoeie –
cieaeoaaeeny; o ia??iae? ?aeiiaaeanoeaioe?? eiioeaio?aoe?y aoi?eiieo
i?iaeoeo?a IIE caeiiii??ii c?inoaea. Iieacieee aeoeaiino? oa?iaio?a AIN
i?e oyaeeiio ia?aa?ao aeeooa??? ci?ithaaeeny ??ciini?yiiaaii: ii/eiath/e
c 2-ai oeaeiy aeoeai?noue eaoaeace c?inoaea, a NIAe – ciaiooaaeany;
cacia/ai? caeiiii??iino? caa??aaeeny o ia??iae? ?aeiiaaeanoeaioe??.
?acoeueoaoe ei?aeyoe?eiiai aiae?co iieacaee, ui c?inoaiiy ai?noo IAeA oa
cieaeaiiy aeoeaiino? NIAe o oai?eo c oyaeeei ia?aa?aii ca?aaeeny c
iiyaith ee?i?ei-eaai?aoi?ieo iciae i?iea?aeeoo (oaae. 2, ?en.3).

Aiae?c iieaciee?a IIE ? aeoeaiino? oa?iaio?a AIN caeaaeii a?ae ee?i?/ii?
oi?ie aeeooa??? iieacaa, ui ?oi? ci?ie caeaaeaoue a?ae iioe?aiino?
i?noeaaiai caiaeueiiai i?ioeano oa ia??iaeo oai?iae: nooi?iue ciaioaiiy
aeoeaiino? oa?iaio?a oa aeoeaaoe?? IIE iaeneiaeueii ae?aaeai? o ia??iae?
?iciaeo oa i?e iioe?aii? i?noeaaiai caiaeueiiai i?ioeano (oaae. 2, ?en.
3).

Aiae?c aeeiai?ee iieaciee?a IIE ? oa?iaio?a AIN caeaaeii a?ae iayaiino?
oneeaaeiaiue i?iaaee o a?oiao oai?eo, ??aiioe?iieo i?ae niaith ca
ee?i?/ieie oi?iaie ? oyaee?noth ia?aa?ao aeeooa???. I?e iaoneeaaeiaiiio
ia?aa?ao a ia??iae? ?iciaeo ?a?no?oaaeiny cieaeaiiy aeoeaiino? oa?iaio?a
AIN, aea ae?aaeaii? aeoeaaoe?? IIE i?e oeueiio ia niinoa??aaeiny. Ne?ae
cacia/eoe, ui ia 2-o oeaei? oa o ia??iae? ?aeiiaaeanoeaioe?? o oai?eo c
iaoneeaaeiaiei ia?aa?aii aeeooa??? iieacieee AeE oa IAeA iaee
oaiaeaioe?th aei c?inoaiiy. I?e aeeooa??eiiio i?iea?aeeo? aeeiai?ea
ai?noo i?iaeoeo?a IIE ? aeoeaiino? oa?iaio?a AIN aoea ?ioith. I?e iiya?
ee?i?/ieo, eaai?aoi?ieo oa AEA iciae i?iea?aeeoo a?aei?/aeiny cia/ia
i?aeaeuaiiy ai?noo AeE oa c?inoaiiy IAeA, ye? ?a?no?oaaeeny ia oii?
iecueeeo iieaciee?a aeoeaiino? eaoaeace, eiioeaio?aoe?? OeI oa
i?aeaeuaiiy aeoeaiino? NIAe. Iae/ano?oa ee?i?ei-eaai?aoi?i? iciaee
i?iea?aeeoo o ianoaaeaieo iaie oai?eo c’yaeyeeny ia 2-io oeaei?, ui
ni?aiaaeaei c iaeneiaeueii ae?aaeaieie ii?ooaiiyie o nenoaiao IIE – AIN.
I?e aeienoe? oai?eo c i?iea?aeeoii a?aei?/aeiny a?aeiiaeaiiy aeoeaiino?
oa?iaio?a AIN, aea IAeA o ieo caa??aaany cia/ii i?aeaeuaiei (oaae. 2,
?en. 3). Eaoaiianoe/ia ianoaaeaiiy oeeo oai?eo aeyaeei ii?iae?caoe?th
iieaciee?a IIE /a?ac 6 i?nyoe?a i?ney aeienee.

Aiae?c iieaciee?a IIE oa oa?iaio?a AIN o oai?eo caeaaeii a?ae nooiaiy
oyaeeino? i?iea?aeeoo iieacaa, ui a?eueo ae?aaeaia cieaeaiiy aeoeaiino?
oa?iaio?a oa cia/ii aeuee ai?no i?iaeoeo?a e?iiia?ieneaeaoe??
niinoa??aaeeny i?e na?aaeiueiio nooiai? oyaeeino? i?iea?aeeoo ii??aiyii
c eaaeei. I?e oyaeeiio i?iea?aeeo? ?a?no?oaaeeny ??cea ciaioaiiy
aeoeaiino? NIAe oa c?inoaiiy aeoeaiino? eaoaeace i?e ??cei i?aeaeuaiiio
aai cia/ii ciaioaiiio ai?no? i?iaeoeo?a IIE.

Oaaeeoey 2

Iaeieae/? iieacieee aeoeaiino? NIAe aecia/aeeny o oai?eo, ye? iiia?ee
a?ae i?iea?aeeoo. A??ia?aeii ieae/a, ii??aiyii c oai?eie ia i?iea?aeeo,
aeoeai?noue NIAe i?ioyaii onueiai no?ieo e?eoaaiiy a?aei?/aeany o oai?eo
?c iiiaeeiieie oneeaaeiaiiyie aeeooa???. I?eaa?oa? oaaao oa, ui ia 1-o
oeaei? caoai?thaaiiy o in?a, ye? ia iaee ia iiiaio iaaeoiaeaeaiiy aei
noaoe?iia?o iciae oneeaaeiaiue aeeooa???, aea iaaeae? aiie ?icaeioeeny,
?a?no?oaaee a??ia?aeii aeu? a?ae ii?ie iieacieee AeE ? IAeA oa ieae/? –
eaoaeace, OeI ? NIAe, ui aeicaiey? i?eionoeoe a?eueoo a??ia?aei?noue
?icaeoeo oneeaaeiaiue aeeooa??? o ethaeae c aioeieneaeaioiith
iaaeinoaoi?noth. Aeyaeai? caeiiii??iino? i?aeoaa?aeaeoaaee ?acoeueoaoe
ei?aeyoe?eiiai aiae?co, caaaeyee yeiio anoaiiaeai? a??ia?aei? cai?ioi?
ca’ycee i?ae aeoeai?noth NIAe oa iayai?noth iiiaeeiieo oneeaaeiaiue ?
oyaee?noth ia?aa?ao aeeooa???.

Ia i?eai?/aiiy aeoeaiino? oa?iaio?a, ia?o ca ana – eaoaeace ye
oa?aeoa?ii? ?ene aeeooa??eii? ?ioaeoe??, iaaieioothoue oaeiae ?io?
aaoi?e (E.A.Oaai?iaa e niaao., 1988; A.A.Iaeueiee e niaao., 1996). A
oiiaao i?eai?/aiiy oa?iaioaoeaii? eaiee AIN i?aeo?eiea caaaeueiiai
aioeieenethaaeueiiai aiiainoaco cae?enith?oueny ca ?aooiie
iaoa?iaioaoeaieo a?iaioeieneaeaio?a oa OeI. I?iaaaeai? iaie
aeine?aeaeaiiy iieacaee, ui cacia/aia caeiiii??i?noue oa?aeoa?ia aeey
eaaeiai ia?aa?ao, yeee ia? i?noea i?e eieae?ciaaieo oi?iao aeeooa???.
Aea iaa?oue o aeaii? eaoaai??? iaoe??io?a o ia??iae? ?aeiiaaeanoeaioe??
c’yaeythoueny iciaee aeoeaaoe?? IIE, ye? iio?aaothoue aaeaeaaoii?
ei?aeoe??. I?e iioe?aii? i?noeaai? caiaeueii? ?aaeoe?? oa i?e c?inoaii?
oieneeico i?aeaeuo?oueny ye nooi?iue i?eai?/aiiy oa?iaio?a AIN, oae ?
?ecee aeniaaeaiiy ?aca?a?a a?iaioeieneaeaio?a, oiane?aeie /iai iiaeeeaa
aeoeaaoe?y IIE. Aeoeaaoe?y IIE iaa?oue ca iayaiino? i?eai?/aiiy
oa?iaio?a AIN iaoiiaeth? ?iaeoeoeaia i?aeaeuaiiy aeoeaiino? eaoaeace ?
NIAe, ui ? niinoa??aaee o oai?eo ?c na?aaeiueioyaeeei ia?aa?aii
aeeooa???. ?ioaineaia i?iaeoeoe?y noia?ieneaeai?ii?aaeeeaeo a oiiaao
ii?ooaiiy oa?iaioaoeaii? eaiee AIN aaaea aei oaeaeeiai aeniaaeaiiy
?aca?aieo iiaeeeainoae nenoaie neioaco NIAe ? iaoiiaeth? c?inoaiiy
ai?noo ia?aeen?a ? iineeaia iaaaioaaeaiiy ia eaoaeaco. A oeeo oiiaao
ai?no eaoaeace ??cei c?inoa?, iaiaaia, ca ?aooiie aea?eueiaiiy ??
iaia?aiica’ycaii? oi?ie, yea iia?e?co?oueny a oiiaao e?eoe/ieo noai?a.
AIN ia iiaea ?aaeaiaiooaaoe ??aaiue IIE, i?ioean iaaoaa?
eaaeiiiiae?aiiai oa?aeoa?o ? iaoiiaeth? nenoaii? aeano?oeoeai?
ii?ooaiiy. Aaciina?aaeiy o/anoue aeeooa??eiiai oieneio o i?eai?/aii? AIN
o i?iaaaeaiiio iaie aeine?aeaeaii? i?aeoaa?aeaeoaaeany ?acoeueoaoaie
aiae?co aieeao i?ioeaeeooa??eii? ne?iaaoee (IAeN) ia iieacieee oa?iaio?a
AIN ? IIE, yeee iieacaa, ui aaaaeaiiy IAeN o ia?o? 3 aei? caoai?thaaiiy
ni?ey? caa?aaeaiith aeoeaiino? oa?iaio?a AIN ? ciaioo? ?ioaineai?noue
IIE. I?iaaaeai? aeine?aeaeaiiy iieacaee oaeiae, ui ?iia??i?noue ?icaeoeo
oyaeeeo oa oneeaaeiaieo oi?i aeeooa??? c?inoa? o oai?eo c iecueeei
aeo?aeiei ??aiai aioeieneaeaioiiai iioaioe?aeo. A?aeiii, ui e?euee?noue
oaeoi??a ?eceeo ?icaeoeo iaaeinoaoiino? a AIN ca?eueoo?oueny inoaii?ie
?ieaie (AE.E.Aa?aiiaa, A.E.Ienaiaaiaeea?, 1985). Oiio oii, yeee ia?aaeo?
caoai?thaaiith ia aeeooa??th, iiaea aooe iani?eyoeeaei (??ciei), ui, o
naith /a?ao, i?ecaiaeeoue aei c?inoaiiy e?eueeino? oai?eo c oyaeeeie oa
oneeaaeiaieie oi?iaie aeeooa???. O/anoue a?eueii?aaeeeaeueieo iaoai?ci?a
o iaoiaaiac? aeeooa??? ie ocaaaeueieee o aeaeyae? noaie, yea iaaaaeaia
ia ?en. 4.

Iieacieee ia?aeeniiai ieeneaiiy e?i?ae?a, aeoeaiino? oa?iaio?a

aioeieneaeaioii? nenoaie oa ?ioi?oaoo o iin??a oieneaaiieo ?
iaoieneaaiieo ooai?a ei?eiaaaeoa??e aeeooa???

Cacia/ai? iieacieee aiae?coaaee o iin??a C.d. caeaaeii a?ae iayaiino?
oieneaaiiino? o caoaeieea, noiooiuei? iaoieia?? EI?-i?aai?a (o?ii?/iiai
oiicee?oo) oa o aeeiai?oe? aei ? i?ney naiaoe?? aioea?ioeeaie.

Aecia/aiiy aeoeaiino? oa?iaio?a AIN o aaeoa??iiin??a caeaaeii a?ae
iayaiino? oieneaaiiino? o C.d. iieacaei, ui iin?enoai C.d.tox+
noi?iaiaeaeo?oueny cieaeaiiyi, ii??aiyii c? caei?iaeie iniaaie,
aeoeaiino? oa?iaio?a AIN (NIAe, eaoaeace, OeI), a i?e iin?enoa? C.d.tox–
oe? ii?ooaiiy ?a?no?othoueny iaio ae?aaeaieie (oaiaeaioe?y aei cieaeaiiy
eaoaeace oa ciaioaiiy ai?noo OeI). O iin??a C.d.tox+ ie?ai? iieacieee
IIE aecia/aeeny aeueie ii??aiyii c iin?yie C.d.tox–. I?ney naiaoe??
aioea?ioeeaie aeoeai?noue oa?iaio?a AIN o iin??a C.d.tox–
a?aeiiaethaaeanue iiai?noth, a i?e iin?enoa? C.d.tox+ – /anoeiai. I?e
oeueiio a iaio a?oiao iin??a C.d. c?inea aeoeai?noue ?aaeoe?e IIE, ui
iiaea aooe iia’ycaia c iia?/iith ae??th aioea?ioee?a.

A?aoiaoth/e, ui o iaoiaaiac? iin?enoaa C.d. aaaeeeaa ?ieue iaeaaeeoue
noaio iiniaeioee, ie i?iaiae?coaaee iieacieee IIE ? AIN o iin??a
C.d.tox+ oa C.d.tox– caeaaeii a?ae iayaiino? o ieo o?ii?/iiai oiicee?oo.
Anoaiiaeaii, ui o iin??a C.d.too+ ?c noiooi?i o?ii?/iei oiicee?oii ? aac
iueiai ci?ie iieacieee aeoeaiino? oa?iaio?a AIN iaee iaeio
ni?yiiaai?noue, aea ca iayaiino? o?ii?/iiai oiicee?oo aeoeai?noue NIAe
?a?no?oaaeany a??ia?aeii ieae/ith. O iin??a C.d.tox– aeoeai?noue
eaoaeace aecia/aeany ieae/ith, ii??aiyii c? caei?iaeie iniaaie, eeoa ca
iayaiino? o?ii?/iiai oiicee?oo, a iieacieee ?ioeo oa?iaio?a AIN iaee
iaeiini?yiiaaiee c “/enoeie” iin?yie C.d.tox– oa?aeoa?. Oaeei /eiii,
aeyaeaii, ui iayai?noue o?ii?/iiai oiicee?oo o iin??a C.d. i??ecaiaeeoue
aei aeniaaeaiiy ?aca?a?a AIN, ui /?oei i?inoaaeo?oueny o iin??a
C.d.tox+. Ia i?aenoaa? io?eiaieo aeaieo iiaeia eiinoaooaaoe, ui
aaaaoaoe?y caoaeieea aeeooa??? ? oieneiiooai?aiiy ei?eiaaaeoa??yie
iiaeooue aooe iia’ycai? c? cieaeaiiyi aeoeaiino? oa?iaio?a AIN. Ca?aeii
c aeaieie e?oa?aoo?e, c? cieaeaiiyi aeoeaiino? eaoaeace iia’ycothoue
?aaeai?an?th i?ioaaa oieneaaiiino? (E.A.Oaai?iaa e niaao., 1988). Ia
aeeeth/aii, ui iayai?noue o?ii?/iiai caiaeueiiai i?ioeano ieaaeaeee?a ?
cieaeaiiy ooieoe?iiaeueii? aeoeaiino? oa?iaioaoeaii? eaiee AIN ? oei
oiiii, ui ni?ey? eiiaa?n?? iaoieneaaiieo ooai?a C.d. o oieneaaii?. Oea
iio?aao? iiaeaeueoiai aeieaco.

Ine?eueee a?ae noaio AIN cia/iith i??ith caeaaeeoue ooieoe?iiaeueia
iiaiioe?ii?noue ?ioiieiiiaoaioieo ee?oei. Ie i?iaiae?coaaee aeeiai?eo
iieaciee?a i?noeaaiai, ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo o iin??a
C.d. I?iaaaeai? aeine?aeaeaiiy iieacaee, ui o iin??a C.d.tox+ ?
C.d.tox– iathoue i?noea i?eai?/aiiy i?noeaaiai ?ioi?oaoo oa
?a?no?othoueny ii?ooaiiy ee?oeiii? eaiee nenoaiiiai ?ioi?oaoo, ye?
i?iyaeythoueny ciaioaiiyi e?eueeino? O-e?ioioeeo?a, i?aeaeuaiiyi ai?noo
0-ee?oei, i?eai?/aiiyi oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a. I?e
iin?enoa? C.d.tox+, e??i cacia/aieo ii?ooaiue, caeiiii??ii ?a?no?oaaee
ciaioaiiy e?eueeino? ?icaoeiooai?thth/eo iaeo?io?e?a oa i?eai?/aiiy
?oiuei? aaeaaceaii? aeoeaiino?. I?ney naiaoe?? aioea?ioeeaie o iin??a
C.d.tox+ ? C.d.tox– i?aeaeuoaaeany aei ??aiy ii?ie e?euee?noue
oaaioeeooth/eo iaeo?io?e?a, aea caeeoaeeny a??ia?aeii ieae/eie,
ii??aiyii c? caei?iaeie aeiii?aie, ai?no O-e?ioioeeo?a oa aeuith –
e?euee?noue 0-ee?oei. Ca iayaiino? o?ii?/iiai oiicee?oo o iin??a C.d.
niinoa??aaee a?eueo ae?aaeaia i?eai?/aiiy iaeo?io?eueiiai ?
e?ioioeeoa?iiai ioe?a ?ioiieiiiaoaioieo ee?oei.

Ioaea, i?iaaaeai? aeine?aeaeaiiy iieacaee, ui iin?enoai C.d.
noi?iaiaeaeo?oueny cieaeaiiyi aeoeaiino? oa?iaio?a AIN ? ?a?no?o?oueny
i?e i?eai?/aii? ooieoe?iiaeueii? aeoeaiino? i?noeaaiai oa ee?oeiiiai
?ioi?oaoo. O iin??a C.d.tox+ aeyaeai? ii?ooaiiy ? a?eueo aeeaieeie.

Ne?ae a?aecia/eoe, ui ii?ooaiiy a ?ioii?e oa aioeieneaeaioi?e nenoaiao,
aeyaeai? iaie o iin??a C.d., ? oaeiae oa?aeoa?ieie aeey noai?a, ui
oi?iothoueny aiane?aeie ae?iaioa?iiai aeao?oeeoo AAI ? ae?? ia i?aai?ci
iani?eyoeeaeo oaeoi??a ciai?oiueiai na?aaeiaeua oa i?ioyaii cia/iiai
/ano iiaeooue ee?i?/ii ia aeyaeyoeny, aea ni?eythoue ?icaeoeo
iaoieia?/iiai i?ioeano (?.A.Iao?ia e niaao., 1983; E.A.Eaaaaeaa,
E.Ae.Iiiyeeia, 1990; A.A.Aa?aaie, 1991, 1994; A.I.O?ieia, E.E.Ieineee,
1997).

Oaeei /eiii, ?acoeueoaoe i?iaaaeaieo aenia?eiaioaeueieo oa ee?i?/ieo
aeine?aeaeaiue na?ae/aoue i?i aaaeeeao ?ieue a?eueii?aaeeeaeueieo
iaoai?ci?a oa ii?ooaiue aioeieenethaaeueiiai aiiainoaco o iaoiaaiac?
aeeooa??eii? ?ioaeoe??, iniaeeai o ?icaeoeo ?? oyaeeeo oa oneeaaeiaieo
oi?i. Aeyaeai? iniaeeaino? ee?i?/ieo ? a?io?i?/ieo iieaciee?a caeaaeii
a?ae ee?i?/iiai ia?aa?ao oa ia??iaeo caoai?thaaiiy ? i?aenoaaith aeey
aeei?enoaiiy AI o eiiieaeni?e oa?ai?? oai?eo ia aeeooa??th ye cania?a
i?io?eaeoeee oyaeeiai oa oneeaaeiaiiai ia?aa?ao caoai?thaaiiy oa iin??a
C.d. c iaoith i?aeaeuaiiy aoaeoeaiino? naiaoe??

I?iaaaeai? ee?i?ei-aenia?eiaioaeuei? aeine?aeaeaiiy aeacothoue oaeiae,
ui aeooaeueiei caaaeaiiyi nueiaiaeaiiy ? ?ic?iaea cania?a
oa?iaeii?io?eaeoeee oa oa?iaeiei?aeoe?? ii?ooaiue aioeieenethaaeueiiai
aiiainoaco, ye? niinoa??aathoueny o in?a ?c i?aeaeuaiith
ni?eeiyoeea?noth aei ?ioaeoe?e aeeoaeueieo oeyo?a.

A?io?i?/i? oa ?ioii? iieacieee o in?a ?c i?aeaeuaiith ni?eeiyoeea?noth
aei ?ioaeoe?e aeeoaeueieo oeyo?a

C iaoith c’ynoaaiiy iaoiaaiaoe/ieo iaoai?ci?a, ye? iaoiiaeththoue
i?aeaeuaio ni?eeiyoeea?noue aei ?ioaeoe?e aeeoaeueieo oeyo?a, ianoaaeeee
3 a?oie iaoe??io?a: aei ? oa?eoee i?aeoe/ii caei?ia? c aenieei ??aiai
?acenoaioiino?, aei ?? ? ??? – iniae c iecueeei ??aiai ?acenoaioiino?
(nooaeaioe c o?ii?/iei oiicee?oii ? o/anieee e?ea?aeaoe?? iane?aee?a
aaa??? ia *AAN a?aeiia?aeii). Ianoaaeai? ? a?oie aoee i?aeoe/ii
caei?iaeie ? i?ioyaii ?ieo ia oai??ee. Ianoaaeai? ?? a?oie /anoi
oai??ee ia A?C c ia?aa?aii o aeaeyae? ?eiioa?eia?o?a,
?eiioa?eiaioiicee?o?a, caaino?aiue oiicee?o?a, on? aiie iaee iciaee
o?ii?/iiai oiicee?oo. E??i oeueiai, o 8 iaoe??io?a oe??? a?oie
ae?aaiinooaaee o?ii?/iee oa?eia?o, o 7 – o?ii?/iee ?ei?o, o 3 – i?iyae
aea?a??. Iciae ?ioeo niiaoe/ieo caoai?thaaiue o in?a ?? a?oie ia aoei.
??? a?oia iaoe??io?a niinoa??aaeany iaie i?ioyaii 2 ?ie?a, on? aiie aoee
ianoaaeai? /a?ac 5–6 ?ie?a i?ney o/ano? o e?ea?aeaoe?? aaa??? ia *AAN.
Aiae?c aiaiianoe/ieo aeaieo, niinoa?aaeaiiy o aeeiai?oe? aeicaieeee
c?iaeoe aeniiaie, ui o ia?aaaaeii? a?eueoino? ianoaaeaieo ??? a?oie
i?ioyaii oeueiai /ano i?aeaeueeany ni?eeiyoeea?noue aei ?ioaeoe?e
aeeoaeueieo oeyo?a. Oae, aei 1986 ?ieo 86% in?a ??? a?oie aoee i?aeoe/ii
caei?iaeie, a o?ii?/iee ia?aa?a ie?aieo ?ioaeoe?e aeeoaeueieo oeyo?a
(oiicee?o, ?ei?o, oa?eia?o) iaa i?noea o 14% ?c ieo. Ia iiiaio
ianoaaeaiiy anoaiiaeaii, ui, ii??aiyii c ia??iaeii aei 1986 ?ieo, a oe?e
a?oi? c?inea e?euee?noue in?a c i?iyaaie o?ii?/ieo oiicee?oo ? ?ei?oo o
2,5 ?ace, oa?eia?oo ? a?iio?oo – o 5 ?ac?a. Ci?ieany oaeiae ia?aa?a
?ioaeoe?e: noaa iaio aino?ei, iaaoa caoyaeiiai ?aoeeaeeaoth/iai
oa?aeoa?o c /anoioith ?aoeeaeea?a 5–6 ca ??e ? a?eueoa.
Ee?i?ei-ia?aee?i?/i? iciaee o?aaeaiiy aeeoaeueieo oeyo?a o ??? a?oi?
aeyaeyeeny o 100% ianoaaeaieo. E??i oeueiai, o 60% c ieo aoa aeyaeaiee
aea?a?/iee neiae?ii, o 50% – aa?iaoe/ia ?ioaeoe?y, o 72% – caoai?thaaiiy
oeoieiai-eeoeiaiai o?aeoo, o 51% – ia?aiai? oa o 28% –
na?oeaai-noaeeiii? nenoai.

Aeine?aeaeaiiy iieaciee?a ?ioi?oaoo, aeoeaiino? oa?iaio?a AIN, ai?noo
i?iaeoeo?a e?iiia?ieneaeaoe??, aaiieiaaoeyoe?? oa aeayeeo ?ioeo
a?io?i?/ieo iieaciee?a ia aeyaeei iaoieia?/ieo ci?i o ianoaaeaieo ?
a?oie. O ?? a?oi? iieacieee ia?eoa?e/ii? e?ia? oa ?ioiia?aie
ci?ithaaeeny o aeia??/eo iaaeao ii?ie, aea, ii??aiyii c ? a?oiith, oe?
ci?ie na?ae/eee i?i i?eai?/aiiy ?ioiii? nenoaie: iaioeie aecia/aeeny
e?euee?noue O- ? O-aeoeaieo e?ioioeeo?a, a?aenioie oaaioeeooth/eo
iaeo?io?e?a, ai?no IgG o ne?iaaooe? oa sIgA o neei?. O ??? a?oi?
niinoa??aaee iciaee ae?aaeaii? ?ioiii? iaaeinoaoiino?: cia/ii ieae/eie,
ii??aiyii c ? a?oiith, ?a?no?oaaeeny ai?no O- ? A-e?ioioeeo?a,
O-aeoeaieo e?ioioeeo?a, e?euee?noue oaaioeeooth/eo iaeo?io?e?a,
eiioeaio?aoe?y IgA, IgM, IgG o ne?iaaooe? oa sIgA o neei?. I?eai?/aiiy
?ioiii? nenoaie o in?a ?? ? ??? a?oi ii?aeioaaeiny c? cieaeaiith
aeoeai?noth oa?iaio?a AIN: o ?? a?oi? a??ia?aeii ieae/ith ?a?no?oaaeany
aeoeai?noue NIAe, o ??? – ieae/ith – NIAe ? OeI oa i?aeaeuaiith –
aeoeai?noue eaoaeace. Ia oeueiio oii? o ?? ? ??? a?oiao aecia/aeiny
c?inoaiiy ai?noo i?iaeoeo?a e?iiia?ieneaeaoe??. O in?a ??? a?oie
?a?no?oaaeeny oaeiae ii?ooaiiy e?i?aeiiai iai?io (i?aeaeuoaaany ai?no
caaaeueieo e?i?ae?a, — ? i?a—EI, oieanoa?eio) oa ?iceaaee
i?e?ioee?eoeyoi?iiai ? eiaaoeyoe?eiiai aaiinoaco, ye?, ye a?aeiii,
iiaeeaeththoue ?ioiiaeai?an?th ? i?ecaiaeyoue aei aeniaaeaiiy ?aca?a?a
AIN. Aeyaeai? o ??? a?oi? ii?ooaiiy a?io?i?/ieo, ?ioiieo oa
aaiieiaaoeyoe?eieo i?ioean?a ca aeaieie e?oa?aoo?e ? oaeoi?aie ?eceeo
e?eoe/ieo noai?a o ?ac? aeieeiaiiy oa ?icaeoeo aino?iai ?ioaeoe?eiiai
caoai?thaaiiy (O.I.Coaee, 1995). Ne?ae cacia/eoe oaeiae, ui aiaeia?/i?
?? a?oi? ianoaaeaieo ci?ie iieaciee?a AIN oa ?ioi?oaoo ?a?no?oaaeeny o
iin??a C.d.

Io?eiai? aeai? na?ae/aoue, ui ii?ooaiiy AIN oa nenoaie ?ioi?oaoo o?nii
iia’ycai? i?ae niaith ? ? aaaeeeaeie oaeoi?aie ?icaeoeo i?aeaeuaii?
ni?eeiyoeeaino? aei ?ioaeoe?e aeeoaeueieo oeyo?a, ui iio?aao? iiooeo
iaoe?aeeeaeo cania?a, cie?aia e?ea?nueeeo i?aia?ao?a eiiieaenii?
iaoiaaiaoe/ii? ae??, ye? a ni?eyee i?aeaeuaiith aeanieo caoenieo nee
i?aai?cio.

Aenia?eiaioaeueia iaa?oiooaaiiy, ioe?iea ee?i?/ii? aoaeoeaiino?
aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? o iin??a ei?eiaaaeoa??e
aeeooa??? oa in?a c o?ii?/iith iaoieia??th aa?oi?o aeeoaeueieo oeyo?a

Iaaaaeai? aeua aeai? i?i iaoiaaiaoe/io ?ieue ii?ooaiue AIN oa ?ioi?oaoo
o oi?ioaaii? i?aeaeuaii? ni?eeiyoeeaino? aei ?ioaeoe?e aeeoaeueieo
oeyo?a iio?aaothoue ?ic?iaee aaeaeaaoieo cania?a oa?iaeii?io?eaeoeee oa
oa?iaeiei?aeoe??. Iaiao?aeiith aeiiaith aei cania?a oaeiai i?ecia/aiiy ?
iaoe?aeeea?noue i?e o?eaaeiio canoinoaaii?. Oiio o i?iaaaeaiiio
aeine?aeaeaii? ie coieieeeny ia ?ic?iaoe? e?ea?nueeiai i?aia?aoo ia
iniia? ?ineeiii? ne?iaeie, cie?aia, ao?iaoea? io?io?iai?.

Aenia?eiaioaeueia iaa?oiooaaiiy canoinoaaiiy ao?iaoea? io?io?iai?
i?iaaee ia iiaeaeyo noai?a, o iaoiaaiac? yeeo aaaeeeaa ?ieue iaeaaeeoue
ii?ooaiiyi AIN oa aeoeaaoe?? IIE: i?iiaiaaiai ooeiaeaeaiiy, o?ii?/ii?
aioeieneaeaioii? iaaeinoaoiino? oa aino?iai caiaeaiiy.

O aeine?aeao in vitro anoaiiaeaii, ui aeno?aeoe, aeaioiaeai? ia 40%
nie?o?, aeoeai?oa, i?ae aeaioiaeai? ia 70%, ?ia?a??othoue IIE o oe?ieiio
ae?aiacii? aeic. Ii??aiyiiy ae?? aeno?aeo?a, aeaioiaeaieo ?c iaaecaiii?
/anoeie ? ei?aiy c ei?aiaaeuai ao?iaoea? io?io?iai?, uiaei aieeao ia
iieacieee IIE ? AIN aeiaaee ?oith ?aeaioe/i?noue, ui iaoiiaeaia
iiae?ai?noth o?oio?i?/iiai neeaaeo ??cieo /anoei ?ineeie. Oiio iaaeae?
iaie aeei?enoiao?oueny oa?i?i “aeno?aeo ao?iaoea? io?io?iai?”.

Aeine?aee c ii?ii?iaiiyi aeeiiai? ia 80 uo?ao-naioeyo: ? a?oio neeaee 10
?ioaeoieo, iieacieee yeeo aoee i?eeiyo? ca ii?io, ?? – 10 uo??a,
oioaeueii ii?ii?iaieo aeicith 5 A?, ??? – uo?e, ye? aei ii?ii?iaiiy
i?ioyaii 3-o oeaei?a io?eioaaee c ei?iii aeno?aeo ao?iaoea? io?io?iai?
?c ?ic?aooieo 0,2; 2,0 ? 5,0 ia/ea iane ca aeiao (ii 20 uo??a o eiaei?e
i?aea?oi?) ? aoee ii?ii?iai? aiaeia?/ii ?? a?oi?. Oaa?ei aeaeai?ooaaee
/a?ac 7 ae?a i?ney ii?ii?iaiiy iaeii/anii o an?o o?ueio a?oiao.
I?iaaaeai? aeine?aeaeaiiy iieacaee, ui ii?ii?iaiiy ?iaeoeoaaei
a?eueii?aaeeeaeuei? i?ioeane, i?i ui na?ae/eei c?inoaiiy ai?noo
ia?aeiieo, aoi?eiieo ? e?ioeaaeo i?iaeoeo?a e?iiia?ieneaeaoe?? o ieaci?
oa oeaieiao ii?ii?iaieo uo??a. ?aae?i?iaeoeiaaia IIE i?ecaaei aei
aeoeaiiai aeo?a/aiiy iecueeiiieaeoey?ieo AI, ia?o ca ana OO o oeaieiao
ia/?iee ? naeac?iee, ui iaoiiaeei cieaeaiiy iieaciee?a caaaeueii? AIA
(oaae. 3). Aaaaeaiiy aeno?aeoo ao?iaoea? io?io?iai? aeicith 2,0 ia/ea,
yea ia?aaeoaaei ii?ii?iaiith, ii?iae?coaaei a?eueo?noue iieaciee?a IIE o
oeaieiao ia/?iee oa naeac?iee. Noaa?e?coth/ee aieea aeno?aeoo ia
a?iiaia?aie i?aeoaa?aeaeoaaany c?inoaiiyi ?acenoaioiino? iaia?ai
a?eo?ioeeo?a aei ia?aeeniiai oa eeneioiiai aaiie?co. Oae, o oaa?ei ???
a?oie a?aenioie aaiie?ciaaieo a?eo?ioeeo?a ciaioeany ii??aiyii c
iieacieeaie ?? a?oie ia 49%, a e?euee?noue ?acenoaioieo a?eo?ioeeo?a o
iiioeyoe?? c?inea a 1,8 ?ace. I?e aaaaeaii? aeno?aeoo oaaioeeoa?ia
aeoeai?noue eaeeioeeo?a ia?eoa?e/ii? e?ia? ii?ii?iaieo uo??a caa??aaeany
ia ??ai? ?ioaeoii? a?oie. Ciaioaiiy ?ioaineaiino? IIE o e?ia? oa
oeaieiao oaa?ei ??? na??? noi?iaiaeaeoaaeiny c?inoaiiyi caaaeue-ii? AIA
oeaiei ia/?iee oa naeac?iee. Cacia/ai? iiceoeai? ci?ie ?a?no?oaaeeny ia
oii? iia?e?caoe?? ?aca?a?a ?aaeien-nenoaie OO. A oiiaao ciaioaiiy ai?noo
iecueeiiieaeoey?ieo AI c?inoaiiy caaaeueii? AIA oeaiei iiaea
iiynithaaoeny ?iaeoeoe??th neioaco oa?iaio?a AIN i?ae aieeaii
i?e?iaeaiaio?a (ia?o ca ana naeaio oa oeeieo), ye? i?noyoueny o ??cieo
/anoeiao ?ineeie.

O ca’yceo c oei, ui aeno?aeo ao?iaoea? io?io?iai? aeaioiaeaiee ia
aoaiie?, a a e?oa?aoo?? ? aeai? uiaei ?aae?ii?ioaeoi?ii? ae?? naiiai
aoaiieo, ie oaeiae i?iaiae?coaaee ci?ie iieaciee?a IIE oa AIN o e?ia? oa
oeaieiao 10 uo??a, ye? aei ii?ii?iaiiy cai?noue aeno?aeoo io?eiaee 40%
aoaiie o a?aeiia?aei?e aeno?aeoo ao?iaoea? aeic?. Anoaiiaeaii, ui
aaaaeaiiy aoaiieo ciaioeei ai?no ia?aeiieo, aea i?aeaeueei – aoi?eiieo ?
e?ioeaaeo i?iaeoeo?a IIE o e?ia? oa oeaieiao ii?ii?iaieo uo??a. Ia
a?aei?io a?ae aoaiieo, i?e aaaaeaii? aeno?aeoo ciaiooaaany ai?no
e?ioeaaeo i?iaeoeo?a e?iiia?ieneaeaoe?? o oeaieiao aeine?aeaeaieo
i?aai?a. E??i oiai, aaaaeaiiy aoaiieo ni?eyei iineeai?e aeo?ao? ?aca?a?a
?aaeien-nenoaie OO oa ?ioeo iecueeiiieaeoey?ieo AI o oeaieiao ia/?iee ?
naeac?iee.

Aeey aea/aiiy ae?? aeno?aeoo ao?iaoea? io?io?iai? a oiiaao ae?iaioa?ii?
iaaeinoaoiino? a?iaioeieneaeaio?a aeei?enoiaoaaee iiaeaeue o?ii?/ii?
aioeieneaeaioii? iaaeinoaoiino?. Aenia?eiaioe i?iaaaeai? ia 91
noaoaaic??eiio e?ieeeo: ? a?oio neeaee 9 ?ioaeoieo oaa?ei, ?? – 46
e?ieee?a, yeeo oo?eioaaee ia iai?aiaoo?aeueiiio aacaioeieneaeaioiiio
?aoe?ii? ? aeaiaeeee c aeine?aeo ia 25, 50 ? 100 aeiao, ??? – 36 oaa?ei,
ye? ia oii? aacaioeieneaeaioiiai ?aoe?iio i?ioyaii 100 ae?a io?eioaaee c
ei?iii uiaeaiii aeno?aeo ao?iaoea? io?io?iai? o aeicao 0,05; 0,2 ? 2,0
ia/ea iane (ii 12 e?ieee?a o eiaei?e i?aea?oi?).

Oaaeeoey 3

Aieea aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? ia iieacieee IIE,
caaaeueii? AIA, oa ai?no aee?i?ic/eiieo a?oai?i?a o oeaieiao ii?ii?iaieo
uo??a

Iieacieee?ioaeoi?,

n=10Ii?ii?iai?, n=10Aeno?aeo (2,0ia/ea) + ii?ii?iaiiy, n=20MmAeE,
ieiieue/ie
(a):10,0390,0020,0440,0030,1000,008***20,280,020,680,03*0,540,03***30,33
0,030,620,04*0,360,01**OE, ieiieue/ie
(a):10,0110,0010,0200,001*0,0100,002**20,120,010,170,02*0,040,01***30,02
00,0040,1600,020*0,0600,002***IAeE, ieiieue/ie
(a):10,0180,0020,0360,002*0,0500,002***20,240,020,240,020,100,01***30,04
00,0080,2000,020*0,0800,006***Oao?a?ie,Ae/ie
(a):10,2500,0580,7200,040*0,6200,057*23,560,245,960,08*3,560,030**31,060
,144,350,40*3,210,10***IAeA, ieiieue/ie
(a):10,2200,0080,2100,0100,2320,01220,840,100,200,02*0,240,02*30,570,060
,280,04*0,340,01*E?iii?aiaioe,23,200,297,260,52*3,320,02**iae.oeoi?./a:3
2,040,085,790,56*2,120,10**Caaaeueia AIA, a?aei.
iae.:10,6000,0400,6000,0410,6000,04221,300,200,200,02*0,400,03***31,200,
200,200,03*0,400,02***OO, ieiieue/ie
(a):10,0610,0070,0570,0070,0300,003***21,110,100,640,06*0,260,01***31,42
0,330,560,08*0,200,02***OOO, ieiieue/ie
(a):10,2320,0400,3040,0320,4400,040***24,460,272,880,22*1,720,22***35,12
1,1103,660,160,900,06***IOO, ieiieue/ie
(a):10,0800,0080,0700,0020,0300,006***20,640,040,560,040,080,01***31,240
,260,760,070,180,02***?aoeiie, ieiieue/ie
(a):10,0550,0020,0480,0070,1000,020***21,760,210,800,08*0,320,05***30,91
0,220,690,110,400,06***Ea?ioei, ieiieue/ie
(a):10,0440,0040,0400,0060,0300,00620,180,020,180,020,180,0330,110,010,0
80,020,260,05***I?ei?oee. Iaoa??ae: 1 – ieacia, 2 – ia/?iea, 3 –
naeac?iea.

* – ??cieoey a??ia?aeia ii??aiyii c a?oiith ?ioaeoieo;

** – ??cieoey a??ia?aeia ii??aiyii c a?oiith ii?ii?iaieo.

Oaa?ei ??? a?oie i?aeaeaee aaoaiac?? ia 100 aeiao aeine?aeo. I?iaaaeai?
aeine?aeaeaiiy iieacaee, ui ae?iaioa?iee aeao?oeeo AI i?ecaiaeeoue aei
ii?ooaiue e?i?aeiiai iai?io, aeoeaaoe?? IIE ? cieaeaiiy aeoeaiino?
oa?iaioaoeaii? ? iaoa?iaioaoeaii? eaiie AIN o e?ia? oa oeaieiao
i?aeaeine?aeieo oaa?ei. Aaaaeaiiy aeno?aeoo ao?iaoea? io?io?iai? o aeic?
0,2 ia/ea iane ia aeiao i?ioyaii onueiai no?ieo aeine?aeo caiia?aei
iaaei??i?e aeoeaaoe?? IIE oa ni?eyei caa?aaeaiith aeoeaiino? oa?iaio?a
AIN ia ??ai? ?ioaeoieo oaa?ei.

I?ioecaiaeueio oa ?aaaia?aoi?io aeoeai?noue aiaeii-nie?oiaiai aeno?aeoo
ao?iaoea? io?io?iai? ioe?ithaaee i?e ciai?oiueiio aeei?enoaii?.
I?ioecaiaeueio ae?th aecia/aee ia iiaeaeyo oa?i?/iiai caiaeaiiy (18
a?eeo ieoae) oa oeueo?ao?ieaoiai? a?eoaie (18 ii?nueeeo naeiie),
?aaaia?aoi?io – ia iiaeae? aeueoa?aoeaiiai caiaeaiiy (18 uo??a). O
eiaeiiio aeine?ae? oaa?eie aoee iiae?eai? ia 2 a?oie: ia?oa, yea ia
io?eioaaea i?aia?ao, ae?oaa – io?eioaaea. Aeno?aeo ?icaiaeeee
o?c?ieia?/iei ?ic/eiii (1:10) ? iaiineee iaoiaeii aie?eaoe?e. Iieacaii,
ui aie?eaoe?? ni?eyee oaeaee?e ?aa?an?? neiioii?a caiaeaiiy ?
i?enei?thaaee caai?iiy oe??ieo ?ai, ui i?aeoaa?aeaeo? iayai?noue o
i?aia?aoo i?ioecaiaeueieo ? ?aaaia?aoi?ieo aeanoeainoae.

Ioaea, iaaaaeai? aeai? na?ae/aoue, ui aeno?aeo ao?iaoea? io?io?iai?
ni?iiiaeiee aaeueioaaoe a?eueii?aaeeeaeuei? i?ioeane iacaeaaeii a?ae
/eiieea, yeee aeeeeeaa iineeaiiy IIE. Aeei?enoaiiy aeno?aeoo coiiaeth?
iiceoeaiee ei?eaoth/ee aieea uiaei iniiaieo iieaciee?a AIN.

Io?eiai? aeai? noaee i?aenoaaith aeey canoinoaaiiy aiaeii-nie?oiaiai
aeno?aeoo ao?iaoea? io?io?iai? o ee?i?oe?.

Ioe?iea ee?i?/ii? aoaeoeaiino? aiaeii-nie?oiaiai aeno?aeoo ao?iaoea?
io?io?iai? i?iaaaeaia o iin??a C.d. oa in?a c o?ii?/iith iaoieia??th
aa?oi?o aeeoaeueieo oeyo?a, ye? iaee iecueeee ??aaiue ?acenoaioiino?.

Aoaeoeai?noue e?eoaaiiy ioe?ithaaee ca ee?i?/ieie, a?io?i?/ieie oa
?ioiieia?/ieie iieacieeaie.

Iin?yi C.d. (10 in?a), o yeeo iin?enoai caoaeieea ?a?no?oaaeiny ia oii?
o?ii?/iiai oiicee?oo, ii?yae ?c caaaeueiiaeciaiith aioeaaeoa??aeueiith
oa?ai??th, i?ecia/aee aiaeii-nie?oiaee aeno?aeo ao?iaoea? io?io?iai? ii
30 e?aiaeue 3 ?ace ca aeaiue i?ioyaii 3 oeaei?a, a oaeiae o aeaeyae?
iieineaiue aeno?aeoii, ?icaaaeaiei 1:10 o?c?ieia?/iei ?ic/eiii 3–4 ?ace
ca aeiao. Eiio?ieueio a?oio neeaee 10 iin??a C.d. ?c noiooi?i o?ii?/iei
oiicee?oii, ye? io?eioaaee eeoa aioeaaeoa??aeueio oa?ai?th.
Aoaeoeai?noue e?eoaaiiy ioe?ithaaee i?ney caaa?oaiiy naiaoe?? oa ca
?acoeueoaoaie ee?i?/iiai niinoa?aaeaiiy ca iin?yie i?ioyaii 6 i?nyoe?a
i?ney aeienee. Anoaiiaeaii, ui i?ney caaa?oaiiy e?eoaaiiy a ianoaaeaieo
iaio a?oi a?aeiiaeeanue aeoeai?noue oa?iaio?a AIN, aea o e?eiaaieo
aeno?aeoii in?a ia niinoa??aaee i?aeaeuaiiy ai?noo i?iaeoeo?a
e?iiia?ieneaeaoe??, yea ?a?nooaaeiny o eiio?ieuei?e a?oi?. I?ecia/aiiy
aeno?aeoo iii?oii aieeaaei ia iieacieee ?ioi?oaoo: o iin??a C.d.
a??ia?aeii i?aeaeueany ai?no A-e?ioioeeo?a oa ?icaoeiooai?thth/eo
iaeo?io?e?a, ciaioeeeny ? aeinyaee ??aiy ii?ie 0-ee?oeie,
a?aeiiaethaaeany ooieoe?iiaeueia aeoeai?noue e?ioioeeoa?iiai oa
iaeo?io?eueiiai ioe?a ?ioiieiiiaoaioieo ee?oei. Cacia/ai? ci?ie
noi?iaiaeaeoaaeeny a??ia?aeiei c?inoaiiyi eiioeaio?aoe?e IgM i IgG o
ne?iaaooe? oa sIgA o neei?, ui aeicaiey? c?iaeoe aeniiaie i?i
?ioiinoeioethth/ee aieea aeno?aeoo. O iaoe??io?a eiio?ieueii? a?oie
i?ney caaa?oaiiy aioea?ioeeioa?ai?? iieacieee ?ioiia?aie nooo?ai ia
ci?ithaaeeny: a?aeiiaethaaeany eeoa oaaioeeoa?ia aeoeai?noue iaeo?io?e?a
oa i?aeaeuoaaany ai?no IgG, aea caa??aaeeny iciaee i?eai?/aiiy
ee?oeiiiai ?ioi?oaoo, ai?no sIgA caeeoeany cieaeaiei (?en. 5). Cacia/ai?
iiceoeai? ci?ie i?aeoaa?aeaeoaaee ?acoeueoaoe eaoaiianoe/iiai
niinoa?aaeaiiy i?ioyaii 6 i?nyoe?a: o iin??a C.d., yeeo e?eoaaee c
aeeth/aiiyi aeno?aeoo ao?iaoea? io?io?iai?, ia niinoa??aaee caaino?aiue
o?ii?/iiai oiicee?oo; o eiio?ieuei?e a?oi? caaino?aiiy oiicee?oo iaee
i?noea o 5 in?a.

Aoaeoeai?noue aeno?aeoo ao?iaoea? io?io?iai? ye caniao ?aaa?e?oaoe??
in?a c iecueeei ??aiai ?acenoaioiino? aea/aee o a?oi? o/aniee?a
e?ea?aeaoe?? aaa??? ia *AAN (12 /ieia?e?a). Aeno?aeo i?ecia/aee ii 30
e?aiaeue 3 ?ace ca aeiao i?ioyaii 3 oeaei?a. sse i?aia?ao ii??aiyiiy
aeei?enoiaoaaee oeiae?i, yeee i?ecia/aee o/anieeai e?ea?aeaoe?? aaa???
ia *AAN (18 /ieia?e?a) o aeic? 10 ia ca aeiao aioo??oiueii’yciai
i?ioyaii 10 ae?a. Ca a?oiaie niinoa??aaee 6–9 i?nyoe?a. Iieacaii, ui
i?ney caaa?oaiiy e?eoaaiiy ianoaaeai? iaio a?oi a?aei?oeee cia/ia
iie?auaiiy caaaeueiiai noaio: i?aeaeueeanue i?aoeacaeaoi?noue,
ciaioeeeny i?iyae anoai?/iiai neiae?iio, cieeee iaoaeaaee i?eniae o
?io?, noaeiie. A iaio a?oiao ianoaaeaieo cia/ii iie?ioeeeny iieacieee
i?noeaaiai oa nenoaiiiai ?ioi?oaoo: ii?iae?coaaeeny O-aeoeai? ?
A-e?ioioeeoe, ai?no IgA, IgG (a a a?oi? c oeiae?iii oaeiae IgM) o
ne?iaaooe?, ciaioeany a?aenioie 0-ee?oei oa i?aeaeueany – oaaioeeooth/eo
iaeo?io?e?a, c?inea eiioeaio?aoe?y sIgA. I?ecia/aiiy aeno?aeoo ao?iaoea?
io?io?iai? iiceoeaii aieeioei ia noai nenoai, ye? ii?oooaaeeny. Oae,
i?ney caaa?oaiiy eo?no ?aaa?e?oaoe?? ciaioeeeny i?e??no IAeA oa ai?no
caaaeueieo e?i?ae?a o ne?iaaooe?, i?aeaeueeany aeoeai?noue NIAe, c?inea
e?euee?noue o?iiaioeeo?a o ia?eoa?e/i?e e?ia? oa iie?ioeeeny ?oi?
aa?aaaoe?ei? aeanoeaino?, ciaioeeeny iciaee AeAC-e?ia? ? ii?iae?coaaeany
a?eueo?noue iieaciee?a eiaaoeia?aie. A a?oi? in?a, ye? io?eiaee oeiae?i,
aeoeai?noue oa?iaio?a AIN caeeoeeany cieaeaiith, i?e??no IAeA, iaaiaee,
ca?eueoeany, i?aeaeueeany e?euee?noue o?iiaioeeo?a o ia?eoa?e/i?e e?ia?,
aea caa??aaeeny iciaee neiae?iio AeAC e?ia?. Ae?aaeaiee ee?i?/iee aoaeo
i?ney eo?no ?aaa?e?oaoe?? aeno?aeoii ao?iaoea? io?io?iai? o ethaeae, ye?
acyee o/anoue o e?ea?aeaoe?? iane?aee?a aaa??? ia *AAN, oo?eioaaany
i?ioyaii 4–5 i?nyoe?a, a i?ney e?eoaaiiy oeiae?iii – 3–4 i?nyoe?.

Iniaai c o?ii?/iei oiicee?oii aac ee?i?ei-ia?aee?i?/ieo iciae ?ioi?
niiaoe/ii? iaoieia?? aeno?aeo i?ecia/aee ii 7–10 e?aiaeue 3 ?ace ca
aeaiue i?ioyaii 3 oeaei?a iaaani?. E??i a?io?i?/ieo oa ?ioiieia?/ieo
iieaciee?a, o oe?e a?oi? in?a aecia/aee eiioeaio?aoe?th ?ii?a Ca2+ i
Fe2+ o ne?iaaooe?. Anoaiiaeaii, ui i?ecia/aiiy i?aia?aoo aaaea aei
c?inoaiiy i?aoeacaeaoiino?, aia?a?eiino?, oaaaeiino?, aaaeuei?ino?,
iie?ioaiiy yeino? nio, iano?ith, ciaioaiiy noiiethaaiino? oiui. I?ney
caaa?oaiiy i?eeiio aeno?aeoo o e?ia? ianoaaeaieo in?a ii??aiyii c
iieacieeaie aei e?eoaaiiy ciaioeany ai?no caaaeueieo e?i?ae?a ?
oieanoa?eio, IAeA, i?aeaeueeany aeoeai?noue oa?iaio?a AIN. C?inoaiiy
aeoeaiino? eaoaeace a?aei?/aeiny ia oii? i?aeaeuaiiy o 1,6 ?ace
eiioeaio?aoe?? ?ii?a Fe2+, ye?, ye a?aeiii, aeei?enoiaothoueny i?e
neioac? oa?iaioa. Caeaoi?noue aeno?aeoo i?aeaeuoaaoe aeoeai?noue
eaoaeace ? ca?eueooaaoe eiioeaio?aoe?th ?ii?a Fe2+ o in?a c iaoieia??th
iiniaeioee iniaeeai i?eaa?ioea iaoo oaaao o ca’yceo c oei, ui, ye
a?aeiii, ?aaeai?an?y i?ioaaa oieneaaiiino? cae?enith?oueny naia i?e
cieaeaii? eiioeaio?aoe?? ?ii?a Fe2+ ? i?eai?/aii? aeoeaiino? eaoaeace
(E.A.Oaai?iaa e niaao., 1988). I?eeii aeno?aeoo ni?eya iie?ioaiith
iieaciee?a i?noeaaiai ? nenoaiiiai ?ioi?oaoo oa aeoeaoaaa oaaioeeoa?io
aeoeai?noue eaeeioeeo?a. Eiai aaaaeaiiy i?aeoe/ii ia aieeioei ia
iieacieee i?e?ioee?eoeyoi?iiai aaiinoaco ? i?enei?eei ? oaco cai?oaiiy
e?ia?, ui aoei iia’ycaia c? c?inoaiiyi ai?noo ?ii?a Na2+ o ne?iaaooe?.

I?eeii aeno?aeoo ao?iaoea? io?io?iai? aeia?a ia?aiineee an? ianoaaeai?:
o aeiaeiiio aeiaaeeo ia aoee ca?a?no?iaai? i?iyae aea?a?/ieo ?aaeoe?e.

Oaeei /eiii, i?iaaaeai? aeine?aeaeaiiy aeiaaee, ui i?ecia/aiiy
aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? ni?ey? c?inoaiith
aaeaioaoe?eieo iiaeeeainoae i?aai?cio oa eiiieaenii aieeaa? ia
o?c?ieia?/i? caoeni? nenoaie in?a c o?ii?/iith iaoieia??th aa?oi?o
aeeoaeueieo oeyo?a, ye? iathoue iecueeee ??aaiue ?acenoaioiino?. Aeai?
e?oa?aoo?e ? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aeicaieeee
noi?ioethaaoe iniiai? oiiae canoinoaaiiy aeno?aeoo ao?iaoea? io?io?iai?
ye caniao, ui i?aeaeuo? ii??i?noue aei ?ioaeoe?e aeeoaeueieo oeyo?a:

1) i?aia?ao iiaea aeei?enoiaoaaoeny aeey e?eoaaiiy oa i?io?eaeoeee
caaaeyee eiiieaeniiio iaoiaaiaoe/iiio aieeao ia ii?ooaiiy, ye? iathoue
i?noea i?e cieaeaiiio ??ai? ?acenoaioiino? o ethaeae c o?ii?/iith
iaoieia??th aeeoaeueieo oeyo?a;

2) eo?ne oa?iaeiei?aeoe?? oa oa?iaeii?io?eaeoeee iiaeii? aooe o?eaaeeie.
I?e ?o i?ecia/aii? ne?ae o?aoiaoaaoe ae?th /eiieea, ui ni?ey? iineeaiith
IIE, oa ??aaiue ?acenoaioiino? i?aai?cio;

3) aea?? aeice i?aia?aoo aecia/a?oueny iaoith (oa?iaeiei?aeoe?y aai
oa?iaeii?io?eaeoeea), a?eii ethaeeie, oa?aeoa?ii oa?/oaaiiy, naciiii;

4) aeioe?eueii i?e i?iaaaeaii? oa?iaeiei?aeoe?? ii?aeioaaoe i?eeii
aeno?aeoo ao?iaoea? io?io?iai? c AI oieioa?ieii, ?aoeiieii oa
?-ea?ioeiii;

5) i?aia?ao iaaeioe?eueii i?ecia/aoe iaoe??ioai c ae?aaeaieie
a?ia?eiaaoeyoe?eieie ci?iaie o e?ia? ca iayaiino? iciae aeai?an??
nenoaie o?a?eiie?co, a oaeiae ii?aeioaaoe eiai aaaaeaiiy c i?aia?aoaie
eaeueoe?th.

Oaeei /eiii, i?iaaaeai? ee?i?ei-aenia?eiaioaeuei? aeine?aeaeaiiy aeiaaee
aeioe?euei?noue aeei?enoaiiy a?ieia?/ii aeoeaieo ?a/iaei
aioeieneaeaioii? ae?? o eiiieaeni?e oa?ai?? oai?eo ia aeeooa??th ye
iaiao?aeii? oiiae caiia?aaiiy oyaeeiio oa oneeaaeiaiiio ia?aa?ao
caoai?thaaiiy, a oaeiae aeicaieeee cai?iiiioaaoe can?a iaoiaaiaoe/iiai
e?eoaaiiy aeey a?aeiiaeaiiy ??aiy caaaeueii? ?acenoaioiino? ?
i?aeaeuaiiy ii??iino? aei ?ioaeoe?e aeeoaeueieo oeyo?a.

Aeniiaee

1. Ee?i?/i? oa aenia?eiaioaeuei? aeine?aeaeaiiy aeiaaee aaaeeeao ?ieue
ii?ooaiue o AIN oa iaaei??ii? aeoeaaoe?? IIE o iaoiaaiac? aeeooa??eii?
?ioaeoe?? oa o oi?ioaaii? i?aeaeuaii? ni?eeiyoeeaino? aei ?ioaeoe?e
aeeoaeueieo oeyo?a, aeicaieeee cai?iiiioaaoe aeine?aeaeaiiy iieaciee?a
i?iiieneaeaioii-aioeieneaeaioiiai aiiainoaco aeey ioe?iee oyaeeino?
ia?aa?ao ? i?iaiicoaaiiy ?icaeoeo oneeaaeiaiue aeeooa??? oa ?ic?iaeoe
i?aia?ao eiiieaenii? iaoiaaiaoe/ii? ae?? aeey oa?iaeiei?aeoe?? oa
oa?iaeii?io?eaeoeee ii?ooaiue, ye? niinoa??aathoueny o in?a c
i?aeaeuaiith ni?eeiyoeea?noth aei ?ioaeoe?e aeeoaeueieo oeyo?a.

2. Ca oiia aenia?eiaioaeueii? aeeooa??eii? ?ioieneeaoe?? o e?ia? oa
oeaieiao aioo??oi?o i?aai?a i?aeaeine?aeieo oaa?ei a?aei?/a?oueny
aeoeaaoe?y ?aaeoe?e a?eueii?aaeeeaeueiiai IIE. Ca nooiaiai aeoeaaoe??
?aaeoe?e e?iiia?ieneaeaoe?? oeaieie aeine?aeaeaieo i?aai?a
?iciiae?eythoueny oaeei /eiii: i?iea?ae naeac?iea ie?ee
iaaeie?eiaeee ia/?iea. Ciaioaiiy ??aiy aoi?eiieo i?iaeoeo?a IIE o
ieaci? ca?aa?oueny c? c?inoaiiyi ?o ai?noo o oeaieiao aioo??oi?o i?aai?a
? na?ae/eoue i?i aeniaaeaiiy noano?aoo IIE.

3. AIN o oeo naieo oiiaao aeine?aeo iia?e?co?oueny aeey ?aaeaiaioaoe??
??aiy ?aaeoe?e a?eueii?aaeeeaeueiiai IIE. Iaeneiaeueii ae?aaeai? ci?ie c
iciaeaie aeniaaeaiiy ? aeenaaeaino c aieo oa?iaioaoeaii? ?
iaoa?iaioaoeaii? eaiie AIN ?a?no?othoueny o i?iea?ae? oa naeac?ioe?
i?aeaeine?aeieo oaa?ei.

4. Iieacieee IIE oa oa?iaio?a AIN o oai?eo ia aeeooa??th iiaeia
aeei?enoiaoaaoe ye aeiaeaoeia? oanoe i?e aecia/aii? oyaeeino? ia?aa?ao
oa aeey i?iaiicoaaiiy ?icaeoeo oneeaaeiaiue.

5. O oai?eo ia aeeooa??th ia? i?noea ciaioaiiy aeoeaiino? oa?iaio?a AIN
? iineeththoueny ?aaeoe?? a?eueii?aaeeeaeueiiai IIE. Ae?aaeai?noue
cacia/aieo ci?i caeaaeeoue a?ae ia??iaeo oa ee?i?/iiai ia?aa?ao oai?iae:

— i?e eaaeiio ia?aa?ao ia oii? cieaeaii? aeoeaiino? oa?iaio?a AIN
??aaiue ?aaeoe?e a?eueii?aaeeeaeueiiai IIE o ia??iae? ?iciaeo oai?iae
oo?eio?oueny a iaaeao ii?ie oa i?aeaeuo?oueny – o ia??iae?
?aeiiaaeanoeaioe??;

— i?e na?aaeiueioyaeeiio ia?aa?ao ia? i?noea cieaeaia aeoeai?noue
oa?iaio?a AIN oa ?a?no?o?oueny i?aeaeuaiee ai?no i?iaeoeo?a IIE o
ia??iae? ?iciaeo; cacia/aia oaiaeaioe?y ci?i aeine?aeaeaieo iieaciee?a
caa??aa?oueny o ia??iae? ?aeiiaaeanoeaioe??;

— i?e oyaeeiio ia?aa?ao o ia??iae? ?iciaeo oai?iae iieacieee aeoeaiino?
oa?iaio?a AIN ci?iththoueny ??ciini?yiiaaii (c?inoa? aeoeai?noue
eaoaeace oa cieaeo?oueny – NIAe), a ai?no i?iaeoeo?a e?iiia?ieneaeaoe??
iiaea ciaiooaaoeny aiane?aeie aeniaaeaiiy noano?aoo IIE; o ia??iae?
?aeiiaaeanoeaioe?? cacia/ai? ci?ie iieaciee?a oa?iaio?a AIN
caa??aathoueny, a ai?no i?iaeoeo?a IIE c?inoa?.

6. Aeiaaaeaiee aca?iica’ycie iineeaiiy ?aaeoe?e IIE c ?icaeoeii
oneeaaeiaiue aeeooa???. Anoaiiaeaii, ui oneeaaeiaiiy aeeooa???
i?iea?aeeoii noi?iaiaeaeo?oueny ?ioaineo?eaoe??th ?aaeoe?e
a?eueii?aaeeeaeueiiai IIE oa aeenaaeainii o oa?iaioaoeai?e eaioe? AIN:

— i?e eaaeiio oa na?aaeiueiio nooiai? neeaaeiino? i?iea?aeeoo
i?aeaeuaiee ai?no i?iaeoeo?a e?iiia?ieneaeaoe?? ?a?no?o?oueny ia oii?
iecueeeo iieaciee?a aeoeaiino? eaoaeace oa i?aeaeuaieo – NIAe;

— i?e oyaeeiio nooiai? neeaaeiino? i?iea?aeeoo iieacieee IIE oa
oa?iaio?a AIN ci?iththoueny ??ciini?yiiaaii (aeoeai?noue NIAe ??cei
ciaioo?oueny, eaoaeace – i?aeaeuo?oueny, ai?no i?iaeoeo?a IIE cia/ii
c?inoa?, a i?e aeniaaeaii? noano?aoo IIE ai?no i?iaeoeo?a
e?iiia?ieneaeaoe?? iiaea ciaiooaaoeny).

?iia??i?noue ?icaeoeo iiiaeeiieo oneeaaeiaiue aeeooa??? aeua o
iaoe??io?a, ye? i?e iaaeoiaeaeaii? aei noaoe?iia?o iaee ieae/? a?ae
ii?ie iieacieee oa?iaio?a AIN oa aeu? a?ae ii?ie iieacieee IIE.

7. Anoaiiaeaii, ui iin?enoai C.d.tox+ i C.d.tox– ?a?no?o?oueny i?e
i?eai?/aii? ooieoe?iiaeueii? aeoeaiino? i?noeaaiai ? ee?oeiiiai
?ioi?oaoo oa noi?iaiaeaeo?oueny cieaeaiiyi aeoeaiino? oa?iaioaoeaii?
eaiee AIN. I?e iin?enoa? C.d.tox+ ii?ooaiiy o cacia/aieo nenoaiao
aeyaeythoueny a?eueo ae?aaeaieie.

8. Iaaooa i?ioyaii aeeooy i?aeaeuaia ni?eeiyoeea?noue aei ?ioaeoe?e
aeeoaeueieo oeyo?a noi?iaiaeaeo?oueny i?eai?/aiiyi i?noeaaiai ?
nenoaiiiai ?ioi?oaoo oa aeniaaeaiiyi ?aca?aieo iiaeeeainoae AIN.

9. Aaaaeaiiy aiaeii-nie?oiaiai aeno?aeoo ao?iaoea? io?io?iai? o
eiiieaenio oa?ai?th iin??a C.d., a oaeiae eiai i?ecia/aiiy iniaai c
iecueeei ??aiai ?acenoaioiino? eiiieaenii aieeaa? ia noai ?oi?o
o?c?ieia?/ieo caoenieo nenoai: ni?ey? a?aeiiaeaiith ooieoe?iiaeueiiai
noaio AIN, i?noeaaiai oa nenoaiiiai ?ioi?oaoo, ui i?aeaeuo? ii??i?noue
aei ?ioaeoe?e aeeoaeueieo oeyo?a.

10. Aaaaeaiiy AI i?yii? ae?? aiienei?io ia oii? aenia?eiaioaeueii?
aeeooa??eii? ?ioieneeaoe?? caiia?aa? iaaei??i?e aeoeaaoe??
a?eueii?aaeeeaeueiiai IIE, ni?ey? caa?aaeaiith ooieoe?iiaeueii?
aeoeaiino? AIN oa aeyaey? ea?ae?ii?ioaeoi?io ae?th, ui iaoiiaeth?
aeioe?euei?noue eiai iiaeaeueoiai ee?i?/iiai aeine?aeaeaiiy o oai?eo ia
aeeooa??th.

N I E N I E

iniiaieo iaoeiaeo ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??

Noaoo?

1.Iaeioi?ua iieacaoaee eiioieoaoa e o?iaaiue naiaiaeii?aaeeeaeueiiai
ieeneaiey eeieaeia o eeoe n aeaoeoeeoii sIgA // A?a/aaiia aeaei.-
1988.-?6.-N.115-116. Ni?aaaoi?e I.I.Eicthe, A.A.Eiaaiue,
I.A.Eicae2.Eco/aiea aeeyiey i?aaeiieaaaaiuo ?aaeeii?ioaeoi?ia ia
ninoiyiea ?aaeien-nenoaiu aeoaieia A a oeaiyo iaeo/aiiuo e?un //
?aaeeaoeeiiiay aeieiaey. ?aaeeiyeieiaey.-1993.-O.33,
aui.2(5).-N.653-657. Ni?aaaoi?e A.A.Ia?aie/, A.O.Ii/a?iyaaa,
A.I.Ieuaiei, I.A.Ie?iiiaa, A.I.Aoaaei, A.A.Iaca?aoe3.Niaoeeoe/iinoue
nenoaiu aioeieneaeaoiie caueou i?aaiia e oeaiae – iniiaa
aeeooa?aioee?iaaiiie oa?iaeioa?aiee aioeieneaeaioaie //
Yenia?eiaioaeueiay e eeeie/aneay oa?iaeieiaey.-1994.-?1.-O.57.-N.47-54.
Ni?aaaoi?e A.I.Aiau?aa, I.I.Aine?anaineee, A.O.Ii/a?iyaaa,
N.A.Noa?iaeoaoeaa4.Oeeoiaaiaoe/i? iane?aeee ii?ii?iaiiy o e?ea?aeaoi??a
aaa??? ia *AAN, i?iaeeaath/eo a Iieoaanueeiio ?aa?ii? /a?ac 6 ?ie?a //
Oe?a?inueeee iaoeiai-iaaee/iee iieiae?aeiee aeo?iae.-1994.-?1.-N.59-61.
Ni?aaaoi?e A.A.I?uaiei, I.A.Eeoaeiaiei, A.A.Eeoaei5.Ee?oeiia ?ioiia
a?aeiia?aeue ia oaaioeeoic i?e aeeooa??? // A?niee i?iaeai a?ieia?? oa
iaaeeoeeie.-1997.-?23.-N.62-71. Ni?aaaoi?e I.I.?cthinueea,
I.?.Oeaa?aeeinueeee6.Ii?oieia?/i? ci?ie o i?iea?ae? i?e
aenia?eiaioaeueiiio aeeooa??eiiio i?iea?aeeo? // A?niee i?iaeai a?ieia??
oa iaaeeoeeie.-1997.-?25.-N.63-71. Ni?aaaoi?e I.I.?cthinueea,
A.A.Ii?aoi7.Iieacieee ia?aeeniiai ieeneaiiy e?i?ae?a oa ii?oieia?/i?
ci?ie o i?iea?ae? oaa?ei c aenia?eiaioaeueiei aeeooa??eiei i?iea?aeeoii
//A?niee i?iaeai a?ieia?? oa iaaeeoeeie.-1997.-?18.-N.52-60. Ni?aaaoi?e
I.I.?cthinueea, A.A.Ii?aoi8.Aeoeai?noue oa?iaio?a aioeieneaeaioiiai
caoenoo oa noai ?ioiii? nenoaie o aaeoa??iiin??a oieneaaiieo ooai?a
ei?eiaaaeoa??e aeeooa??? // ?ioaeoe?ei? oai?iae.-1998.-?1.-N.15-18.
Ni?aaaoi?e I.I.?cthinueea, E.E.E?eaaiei, E.E.Aieoaiei9.Noai nenoaie
aioeieneaeaioiiai caoenoo o oaa?ei c aenia?eiaioaeueiith aeeooa??eiith
?ioieneeaoe??th // E?ee.-1998.-?4.-N.63-6510.Aieea aiienei?io ia noai
i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a o oaa?ei c
aenia?eiaioaeueiith aeeooa??eiith ?ioieneeaoe??th // E?ee.
-1998.-?3.-N.46-4811.Aeoeai?noue aioeieneaeaioieo oa?iaio?a o
aaeoa??iiin??a oieneaaiieo ? iaoieneaaiieo ooai?a ei?eiaaaeoa??e
aeeooa??? // I?iaeaie aeieia?? oa iaaeeoeeie.-1998.-O.2,
?5-6.-N.71-7212.Noai ?ioiii? nenoaie o aaeoa??iiin??a oieneaaiieo oa
iaoieneaaiieo ooai?a ei?eiaaaeoa??e aeeooa??? // I?iaeaie aeieia?? oa
iaaeeoeeie.-1998.-O.2, ?5-6.-N.73-7513.Noai o?c?ieia?/ieo caoenieo
nenoai o ethaeae ?c i?aeaeuaiith ni?eeiyoeea?noth aei ?ioaeoe?e
aeeoaeueieo oeyo?a // I?iaeaie aeieia?? oa iaaeeoeeie.-1999.-O.3,
?1-2.-N.52-55.14.?acoeueoaoe aeei?enoaiiy aiaeii-nie?oiaiai aeno?aeoo
ao?iaoea? io?io?iai? o eiiieaeni?e oa?ai?? iin??a ei?eiaaaeoa??e
aeeooa??? // I?iaeaie aeieia?? oa iaaeeoeeie.-1999.-O.3, ?1-2.-N.
41-43.15.Noai nenoaie ?ioi?oaoo o oai?eo ia aeeooa??eiee i?iea?aeeo //
E?eoaaeueia ni?aaa.– 1998.– ? 6.– N. 40-44. Ni?aaaoi?
I.I.?cthinueea16.Iniaeeaino? nenoai ia?aeeniiai ieeneaiiy e?i?ae?a oa
aioeieneaeaioiiai caoenoo a oeaieiao ??cieo i?aai?a i?e
aenia?eiaioaeuei?e aeeooa??ei?e ?ioieneeaoe?? // ?ioaeoe?ei? oai?iae.–
1999.–? 1.–N.32–36.17.Study of properties of rat blood cellss on
exposure to ionizing radiation against a baskground of introduction of
presumed radioprotectoes // Biophysics.-1996. -V.41, N3.-P.787.
Ni?aaaoi?e A.V.Paranich, V.P.Mishchenko, A.G.Trokhimenko,
V.F.Pochernjaeva18.Eco/aiea ?aaeeii?ioaeoi?iuo naienoa iaeioi?uo
eaea?noaaiiuo i?aia?aoia ii eciaiaieth o?iaiy i?iaeoeoia
?aaeeieiaeooee?iaaiiiai IIE a oeaiyo e?un // ?aae.aeo?i.Aeioeceea. Aeai.
a AEIEOE ?817-1395 io 24.03.95.-Aeioeceea.-1995.-O.40,
aui.3.-N.697-698. Ni?aaaoi?e E.A.*aeeeia, A.O.Ii/a?iyaaa, A.A,Ia?aie/,
I.I.AEeaaeiaa, A.I.Ieuaiei, A.A.Iaca?aoe, A.I.AoaaeiIaoaioe

1.Can?a aeey i?io?eaeoeee ? e?eoaaiiy a?eueii?aaeeeaeueiiai
iioeiaeaeaiiy i?aai?a ? oeaiei // Iaoaio Oe?a?ie 9481 A a?ae 30.09.1996
?. Ni?aaaoi?e

A.A.Aoiueei, A.O.Ii/a?iy?aa, A.I.Aiae?ueia, A.A.Ia?ai?/, A.O.Ii?na?aa,
A.?.Ae?ooy?ueia2.Niin?a ae?aaiinoeee aeeooa??eiiai i?iea?aeeoo // Iaoaio
Oe?a?ie ?17556 A a?ae 06.05.1997 ?. Ni?aaaoi?e I.I.?cthinueea,
I.I.Eicthe, E.O.Aia?i?/, E.E.Aieoaiei, E.E.E?eaaiei,3.Niin?a ?aiiuei?
ae?aaiinoeee aeeooa??? // Iaoaio Oe?a?ie ?20917 A a?ae 07.10.1997 ?.
Ni?aaaoi?e I.I.?cthinueea, I.I.Eicthe, E.O.Aia?i?/, E.E.Aieoaiei,
E.E.E?eaaiei4.E?eoaaeueii-i?io?eaeoe/iee i?iaeoeo // Iaoaio Oe?a?ie
24300 A a?ae 07.07.1998 ?. Ni?aaaoi?e E.I.Noiyiiaa, A.O.Ii/a?iy?aa,
A.I.Aiae?ueia, TH.Ae.Ieeeiaiei, O.I.Oaaei?ia, E.Ae.Aieueaa?a,
A.A.Aaeoaiaoeue5.Niin?a ii?iae?caoe?? oeaieiiiai iai?io oa a?aeiiaeaiiy
ii?oiooieoe?iiaeueiiai noaio i?aai?a ? oeaiei // ??oaiiy ia aeaea/o
iaoaioo Oe?a?ie a?ae 11.11.1998 ?. ca cayaeith 98002682 a?ae
09.02.1998?. Ni?aaaoi?e I.A.Noaoaiia, A.N.Aeaieeaiei, O.A.Eiaaeue/oe,
A.I.Aiae?ueia, A.O.Ii/a?iy?aa, A.A.Aoiueei

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