.

Клініко-патогенетичне обгрунтування медикаментозних і немедикаментозних методів лікування гострих ендометритів: Автореф. дис… канд. мед. наук / П.Й.

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?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

NOAAEI

IAAEI EINEIIAE*

OAeE 618.14-002-036.11-085

EE?I?EI-IAOIAAIAOE*IA IAA?OIOOAAIIss

IAAeEEAIAIOICIEO ? IAIAAeEEAIAIOICIEO

IAOIAe?A E?EOAAIIss AINO?EO AIAeIIAO?EO?A

14.01.01 — aeooa?noai ? a?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioo aeeiiaii a Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai IIC Oe?a?ie.

IAOEIAEE EA??AIEE:

aeieoi? iaaee/ieo iaoe, i?ioani?

O?AI*OE AIAOIE?E THOEIIAE*

Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss.Ai?aa/aanueeiai
IIC Oe?a?ie i?ioani? eaoaae?e aeooa?noaa oa a?iaeieia?? iaaee/iiai
oaeoeueoaoo

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani?

NIEUeNUeEEE ssE?A II?OE??EIAE*

?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie

caa?aeoaa/ a?aeae?eaiiy a?iaeieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

EIOAIAAE* ?AAAI?ss A?EOI??AIA

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC
Oe?a?ie caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaeieia?? ?2

I?IA?AeIA ONOAIIAA:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey IIC Oe?a?ie
(i. Ee?a), eaoaae?a aeooa?noaa oa a?iaeieia?? ? 1.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “18” /a?aiy 1999 ?. i 13 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee (Ae 26.553.01) ii caoenoo
aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai ? a?iaeieia?y” i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (aae?ana: 252050, i.
Ee?a, aoe. Iaio?euenueeiai, 8).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a, aoe.
Iaio?euenueeiai, 8).

Aaoi?aoa?ao ?ic?neaiee ” 08 ” o?aaiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
     EAAOI?IA  E.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia ai?eii-caiaeueieo caoai?thaaiue o
i?neyiieiaiaiio oa i?neyaai?oiiio ia??iaeao i?iaeiaaeo? caa??aaoe naith
aeooaeuei?noue aeey a?o/eciyii? oa caei?aeiiii? iaaeeoeeie ?,
iacaaaeath/e ia oni?oio ?aae?caoe?th aaaaoueio ?? aniaeo?a, caeeoa?oueny
iaei??th c aieiaieo i?e/ei iaoa?einueei? caoai?thaaiino? oa nia?oiino?
[Aaioee?anueeee A.I. oa ni?aaao., 1996; Nieuenueeee ss.I., 1996;
Noaiaie?anueea A.E., 1996; Hoyme U.B., 1994; McCormack W.M., 1994].

I?iaeaia i?neyiieiaiaeo oa i?neyaai?oieo ai?eii-caiaeueieo caoai?thaaiue
iaaoaa? o aeaiee /an iniaeeai? aeooaeueiino? o ca’yceo ?c cieaeaiiyi
?ioiieia?/ii? ?aaeoeaiino? i?aai?cio, ca?eueoaiiyi e?eueeino?
iia?aoeaieo ?ic?iaeaeaiue, oe?ieei ai?iaaaeaeaiiyi aioea?ioee?a oa
/anoei ?o ia?aoe?iiaeueiei aeei?enoaiiyi, ui i?ecaiaeeoue aei aeieeiaiiy
aioea?ioeei?acenoaioieo aini?oaeueieo ooai?a i?e?ii?aai?ci?a, ci?ie
ii?iaeueii? i?e?ioei?e noaoaaeo oeyo?a ae?iie a i?neyiieiaiaiio oa
i?neyaai?oiiio ia??iaeao [?aaithoa N.I., 1991; Ao?oiaie A.E. e niaao.,
1996; ?aaithoa E.?., 1996; Maccato M.l. et al., 1991; Henr?ques C.U. et
al., 1994].

Iaea?eueo iioe?aiei i?iyaii i?neyiieiaiai? oa i?neyaai?oii? ?ioaeoe?? ?
aino?ee  aiaeiiao?eo.  I?ney o?c?ieia?/ieo  iieia?a a?i cono??/a?oueny o
2-10 % aeiaaee?a, iaoieia?/ieo — o 18-20 %, iia?aoe?e eana?nueeiai
?icoeio — a?ae 6-11 % aei 25-30 %, a?oeo?oe?aeueieo aai?o?a — o 5-10 %,
ieiia?eueieo — o 10-20 % [Aieioa A.ss., 1992; Oi?eue N.A., 1994;
Ieoaeeaiei I.O., 1995; Magee K.P. et al, 1994; Sweet R.L. et al., 1994].

Iacaaaeath/e ia /eneaii? ioae?eaoe??, i?enay/ai? i?iaeai?
ai?eii-caiaeueieo caoai?thaaiue a aeooa?noa? oa a?iaeieia??, ?yae
ieoaiue iaoiaaiaco aino?iai aiaeiiao?eoo, iaoiaee oa?ai?? aeaiiai
caoai?thaaiiy caeeoathoueny ua iaaeinoaoiuei aea/aieie. O e?oa?aoo??
cono??/athoueny eeoa iiiaeeiie? ?iaioe, ye? aeathoue iiaeeea?noue
eiiieaenii ioe?ieoe ?ioaa?aeueiee noai i?ioean?a ia?aeeniiai ieeneaiiy
e?i?ae?a ee?oeiieo iaia?ai (IIE) ? nenoaie aioeieneaeaioiiai caoenoo
i?aai?cio (AINC), aecia/eoe ?o aaciina?aaeith ?ieue a iaoai?ciao
?icaeoeo oeo iaoieia?/ieo ci?i, ui iathoue i?noea i?e aino?iio caiaeaii?
aiaeiiao??th. Iaaeinoaoiuei aeaieo i?i aca?iica’ycie i?ae ci?iaie c aieo
nenoaie ?ioi?oaoo ? noaiii a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a i?e
aeaiiio aeae? iaoieia??. Caeeoa?oueny a?aee?eoei ieoaiiy i?i aieea
aioa?ini?aoe?? ia i?ioeane ia?aeeniiai ieeneaiiy e?i?ae?a.

Aeey e?eoaaiiy aino?eo aiaeiiao?eo?a ii?yae c aioeaaeoa??aeueieie
i?aia?aoaie, canoiniaothoueny caniae, ye? aieiae?thoue
iaia?aiii?ioaeoi?ieie, aioeieneaeaioieie oa ?ioiiiiaeoethth/eie
aeanoeainoyie [Aie/oe A.A., 1989; Aaeiae/aiei TH.I., 1991; Iioiaeoi
E.A., 1995; Caaie?eoeueeee A.A., 1997].

C iaoith ciaioaiiy ee?i?/ieo oa eaai?aoi?ieo i?iya?a aiaeioieneeico,
ei?aeoe?? i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a,
i?aeaeuaiiy ?ioiieia?/ii? oiea?aioiino? i?aai?cio oai?eo, ie
aeei?enoiaoaaee iiaee aioa?ini?aaio aioa?inaaeue o ii?aeiaii? c
/a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia? iai?ai?ia?aeieeiaei eaca?iei
aia?aoii “Eo/-2” i?e aeiaaeei? oaee? 820 ii ? iiooaeiino? 35 iAo/ni2.

Aioa?inaaeue — a?ae?iaaeue iaoeee?aii??ai? eeneioe a?eiai eieuei?o, aac
niaeo oa caiaoo, ia?ic/eiy?oueny o aiae?. I?e aaeeaaii? i?aia?ao ia
ooeiaeaeo? neeciao iaieiieo oeoieiai-eeoeiaiai o?aeoo, ia ii?ooo?
i?eno?ieiaa o?aaeaiiy, /a?ac 7-8 aiaeei aeaiaeeoueny c i?aai?cio.
Aioa?inaaeue aaeni?ao? c eeoeiaiai ai?noo oa e?ia? (/a?aciaia?aiii c
eai?ey??a ai?neiie neeciai? iaieiiee eeoe?aieea) oiene/i? ?a/iaeie ?
i?iaeoeoe iacaaa?oaiiai iaoaaie?cio. I?aia?ao ciaioo? i?iyae oieneeic?a,
iie?auo? ooieoe?th eeoe?aieea, ia/?iee, ie?ie. Oeae e?ea?nueeee can?a
iaia? iia?/ieo aoaeo?a oa i?ioeiieacaiue. Eeoa a aeayeeo aeiaaeeao
iiaeeeaa ?iaeea?aeoaeueia iaia?aiinei?noue aioa?inaaey [Ea?aeeeia A.A.,
1991; Iaeaea E.A. e niaao., 1993; Nooaiiaa A.A., 1993; A?euaiei I.I. oa
ni?aaao., 1994; Oaa/aiei TH.I. oa ni?aaao., 1994].

O aeinooii?e iai e?oa?aoo?? ie ia ciaeoee ?ia?o, i?enay/aieo
canoinoaaiith aioa?inaaey a e?eoaaii? aino?eo aiaeiiao?eo?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia a?aeiia?aeii aei ieaio iaoeiai-aeine?aeieo ?ia?o
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i.
?.ss.Ai?aa/aanueeiai IIC Oe?a?ie (? aea?ae?a?no?aoe?? 0195U009227).

Iaoa aeine?aeaeaiiy. Iaoa aeaii? ?iaioe iieyaa? o i?aeaeuaii?
aoaeoeaiino? e?eoaaiiy oai?eo aino?ei i?neyiieiaiaei oa i?neyaai?oiei
aiaeiiao?eoii ia iniia? aecia/aiiy ??aiy aiaeiaaiii? ?ioieneeaoe??
i?aai?cio, aea/aiiy c?ooaiue a nenoai? IIE/AINC, ?ioiiiio noaoon? oa ?o
ei?aeoe?? ca ?aooiie aeei?enoaiiy a eiiieaeni?e oa?ai?? aioa?inaaey oa
/a?acnoaeeiiiai eaca?iiai ii?ii?iaiiy e?ia?.

Iniiai? caaea/?:

1. Aea/eoe noai ia?aeeniiai ieeneaiiy e?i?ae?a, oa?iaioaoeaio
aeoeai?noue aioeieneaeaioii? nenoaie caoenoo i?aai?cio oai?eo aino?ei
i?neyiieiaiaei oa i?neyaai?oiei aiaeiiao?eoii.

2. Aeine?aeeoe nooi?iue ii?ooaiiy iieaciee?a ianiaoeeo?/ii?
?acenoaioiino? oa aoii?aeueiiai ?ioi?oaoo i?e aino?iio caiaeaii?
aiaeiiao??th.

3. Aecia/eoe ??aaiue aiaeiaaiii? ?ioieneeaoe?? i?aai?cio oai?eo aino?ei
i?neyiieiaiaei oa i?neyaai?oiei aiaeiiao?eoii.

4. I?iaanoe ee?i?ei-eaai?aoi?io ioe?ieo aoaeoeaiino? canoinoaaiiy
aioa?inaaey oa /a?acnoaeeiiiai eaca?iiai ii?ii?iaiiy e?ia? a eiiieaeni?e
oa?ai?? aino?eo aiaeiiao?eo?a.

5. ?ic?iaeoe ?aeiiaiaeaoe?? ii aaeineiiaeaiith iaoiae?a ianoaaeaiiy ?
e?eoaaiiy oai?eo aino?ei i?neyiieiaiaei oa i?neyaai?oiei aiaeiiao?eoii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa, anoaiiaeaii i?ia?aeio
?ieue aiaeiaaiii? ?ioieneeaoe?? a iaoiaaiac? aino?eo aiaeiiao?eo?a.

Iieacaia ??cieoey o ia?aiao?ao a?io?i?/iiai oa ?ioiiiai noaoono
i?aai?cio oai?eo aino?ei i?neyiieiaiaei oa i?neyaai?oiei aiaeiiao?eoii.

Aeiaaaeaii, ui aioa?ini?aaioe (ia i?eeeaae? aioa?inaaey) o ii?aeiaii? c
/a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia? ca ?aooiie e?ea?aeaoe??
i?iya?a aiaeioieneeico, noaa?e?caoe?? i?ioean?a a?eueii?aaeeeaeueiiai
ieeneaiiy e?i?ae?a ee?oeiieo iaia?ai, i?aeaeuaiiy iioaioe?aeo AINC oa
iia’ycaiith c oeei noeioeyoe??th A-eaiee ?ioi?oaoo ? ianiaoeeo?/ii?
?acenoaioiino? i?aai?cio, iiaeii? iin?aeaoe iaeia c i?ia?aeieo i?noeue o
eiiieaeniiio e?eoaaii? ae?iie c aino?eie aiaeiiao?eoaie.

Ia oe?e iniia? aia?oa a aeooa?nueei-a?iaeieia?/i?e i?aeoeoe? ?ic?iaeaii
eiiieaeniee iaoiae e?eoaaiiy aino?eo i?neyiieiaiaeo oa i?neyaai?oieo
aiaeiiao?eo?a ?c aeei?enoaiiyi aioa?inaaey oa /a?acnoaeeiiiai eaca?iiai
ii?ii?iaiiy e?ia? ia oii? aioeaaeoa??aeueii? oa aeac?ioieneeaoe?eii?
oa?ai??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Cai?iiiiiaaii aoaeoeaiee
iaoiae e?eoaaiiy aino?eo aiaeiiao?eo?a ?c canoinoaaiiyi aioa?inaaey o
ii?aeiaii? c /a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia?. Ca aeiiiiiaith
ii??aiyeueii? ioe?iee ee?i?/ieo oa eaai?aoi?ieo aeaieo aeiaaaeaia eiai
ia?aaaaa iaae caaaeueiii?eeiyoith oa?ai??th oa e?eoaaiiyi c
aeei?enoaiiyi eeoa eaca?iiai ii?ii?iaiiy. Anoaiiaeaia iiaeeea?noue
aeei?enoaiiy iieaciee?a ia?aeeniiai ieeneaiiy e?i?ae?a,
aioeieneaeaioiiai caoenoo, ?ioiieia?/ii? ?aaeoeaiino? oa aiaeiaaiii?
?ioieneeaoe?? i?aai?cio aeey ioe?iee aoaeoeaiino? canoiniaoaaii?
oa?ai??.

?ic?iaeaiee eiiieaeniee iaoiae e?eoaaiiy oai?eo aino?ei i?neyiieiaiaei
oa i?neyaai?oiei aiaeiiao?eoii ?c aeei?enoaiiyi aioa?inaaey o ii?aeiaii?
c /a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia? ai?iaaaeaeaii o
a?aeae?eaii? eiina?aaoeaii? a?iaeieia?? Oa?iii?euenueeiai i?nueeiai
ee?i?/iiai iieiaiaiai aoaeeieo, a a?iaeieia?/ieo a?aeae?eaiiyo
??aiainueeiai i?nueeiai ee?i?/iiai iieiaiaiai aoaeeieo ?1,
*a?i?aaoeueeiai i?nueeiai ee?i?/iiai iieiaiaiai aoaeeieo ?1,
*a?i?aaoeueeiai i?nueeiai ee?i?/iiai iieiaiaiai aoaeeieo ?2,
Oa?aaiaeyinueei?, Eic?anueei?, Aonyoeinueei?, Ao/aoeueei? Oe?E
Oa?iii?euenueei? iaeano?.

Iniaenoee aianie caeiaoaa/a:

1. I?iaaaeaii ee?i?ei-noaoenoe/iee aiae?c ia?aa?ao caoai?thaaiiy o 176
oai?eo aino?ei aiaeiiao?eoii, ianoaaeaii 28 caei?iaeo iaaaa?oieo ae?iie
oa?oeeueiiai a?eo.

2. Naiino?eii aeeiiaii caa?? aeine?aeiiai iaoa??aeo c iaoith aecia/aiiy
iieaciee?a ia?ieneaeaoe?? iaia?aiieo e?i?ae?a, oa?iaioaoeaii?
aioeieneaeaioii? nenoaie caoenoo, aiaeiaaiii? ?ioieneeaoe?? i?aai?cio,
ianiaoeeo?/ii? ?acenoaioiino?, nenoaie aoii?aeueiiai ?ioi?oaoo.

3. Iniaenoi i?iaaaeaia eo?aoe?y i?io?eueieo oai?eo a iaeaoao
a?iaeieia?/ii? ee?i?ee Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??.

4. I?iaaaeaii aiae?c, noaoenoe/io ia?iaeo oa ioe?ieo an?o iaea?aeaieo
?acoeueoao?a, c?iaeaii a?aeiia?aei? aeniiaee oa i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai?
ia XXXVIII i?aenoieia?e iaoeia?e eiioa?aioe?? Oa?iii?euenueeiai
iaaee/iiai ?inoeoooo “Aeinyaiaiiy ? ia?niaeoeae ee?i?/ii? oa
aenia?eiaioaeueii? iaaeeoeeie” (Oa?iii?eue, 1995); XXXIX i?aenoieia?e
iaoeia?e eiioa?aioe?? Oa?iii?euenueeiai iaaee/iiai ?inoeoooo “Caeiaooee
ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie” (Oa?iii?eue, 1996);
iaoeiaiio can?aeaii? iaeanii? anioe?aoe?? aeooa??a-a?iaeieia?a
(Oa?iii?eue, 1997); ni?eueiiio can?aeaii? eaoaae? aeooa?noaa oa
a?iaeieia?? iaaee/iiai oaeoeueoaoo, aeooa?noaa oa a?iaeieia??
oaeoeueoaoo i?neyaeeieiiii? ina?oe, o??o?a?? oaeoeueoaoo i?neyaeeieiiii?
ina?oe, aini?oaeueii? oa?ai?? ?2, ee?i?/ii? oa?iaeieia?? ? o?oioa?ai??
iaaee/iiai oaeoeueoaoo Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. I.ss.Ai?aa/aanueeiai.

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 6 ?ia?o, c ieo 5 — o
i?ia?aeieo aeo?iaeao, 1 — o oacao iaoeiaeo eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 161
noi??ioe? ae?oeiaaiiai oaenoo ? neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iaoa??ae?a oa iaoiae?a aeine?aeaeaiue, ?icae?e?a aeanieo
aeine?aeaeaiue, aiae?co ? ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiue,
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa nieneo aeei?enoaii? e?oa?aoo?e,
yeee i?noeoue 200 i?aoeue a?o/eciyieo ? 100 caei?aeiiieo aaoi??a, ye?
caeiathoue 38 noi??iie. ?iaioa ?ethno?iaaia 29 oaaeeoeyie oa 2
penoieaie, ye? caeiathoue 29 noi??iie.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiue. Ee?i?/i? aeine?aeaeaiiy
cae?enithaaee ia aac? a?iaeieia?/iiai a?aeae?eaiiy ee?i?/iiai iieiaiaiai
aoaeeieo ?1 i.Oa?iiiiey oa eaai?aoi??? eaoaae?e aeooa?noaa ? a?iaeieia??
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i.
?.ss.Ai?aa/aanueeiai ca ia??iae c 1991 ii 1998 ?iee.

I?ae iaoei niinoa?aaeaiiyi ciaoiaeeeinue 204 ae?iee. An? ianoaaeai? aoee
?icae?eai? ia 7 ee?i?/ieo a?oi. A ia?oo, eiio?ieueio, aa?eoei
28 caei?iaeo iaaaa?oieo ae?iie oa?oeeueiiai a?eo. A ae?oao — 30 oai?eo
aino?ei i?neyaai?oiei aiaeiiao?eoii, ye? io?eioaaee oa?ai?th, iaea?eueo
iioe?aio o ee?i?oe? eaoaae?e aeooa?noaa oa a?iaeieia?? Oa?iii?euenueei?
iaaee/ii? aeaaeai??. I?e aioeaaeoa??aeueiiio e?eoaaii? aeei?enoiaoaaee
ne?aeoth/? i?aia?aoe: aii?oeee?ia iao???ao n?eue ii 1,0 a
aioo??oiueii’yciai 4 ?ace ia aeiao i?ioyaii 7-10 ae?a, aaioai?oeeia
noeueoao ii 0,08 a aioo??oiueii’yciai 3 ?ace ia aeiao i?ioyaii 5-7 ae?a,
oeaoacie?i (eaocie) ii 1,0 a aioo??oiueii’yciai aai aioo??oiueiaaiii 3
?ace ia aeiao i?ioyaii 7-10 ae?a (ye i?aaeei, oai?? iaea?aeoaaee
eiia?iaoe?th aeaio c iaaaaeaieo aioea?ioee?a, a?aoiaoth/e /ooeea?noue
aei aeae?eaii? i?e?ioei?e), iao?ii?aeacie ii 0,5 a ia?i?aeueii 4 ?ace ia
aeiao i?ioyaii 7-8 ae?a aai iao?ia?e ii 100 ie aioo??oiueiaaiii 3 ?ace
ia aeiao i?ioyaii 5-7 ae?a. Aeey aeac?ioieneeaoe?? aeei?enoiaoaaee
?aiiie?aethe?i, ?aiaethiai oa e?enoaei?aei? ?cioii?/i? ?ic/eie. E??i
oiai, oe? ae?iee iaea?aeoaaee a?oai?ie a?oie A oa a?oai?i N. I?e aaaee?e
oi?i? aiai?? i?iaiaeeee o?ainooc?th a?aeieoeo a?eo?ioeeo?a aeaa ?ace ia
oeaeaeaiue. C iaoith naiaoe?? aiaieua ?ioaeoe?? c?iooaaee ii?iaeieio
iaoee 0,02 % ?ic/eiii oei?aaeneae?io 1 ?ac ia aeiao, ia a?eueoa 3-4
?ac?a. sseui aiaeiiao?eo aeieeaa ia oii? caeeoie ie?aeiiai yeoey ( o
68,7 % oai?eo), oi i?ney 3-4 c?ioaiue ii?iaeieie iaoee, i?ae i?ee?eooyi
aioea?ioee?a, i?iaiaeeeinue aene??aaiiy no?iie ii?iaeieie iaoee. Oaea
oa?ai?y a iine?aeoth/iio o aaoi?aoa?ao? iaceaa?oueny “o?aaeeoe?eiith”
aai “caaaeueiii?eeiyoith”. O?aoy a?oia — 26 iaoe??ioie c aino?ei
i?neyaai?oiei aiaeiiao?eoii — io?eioaaea iaaaaeaia aeua e?eoaaiiy oa
/a?acnoaeeiia eaca?ia ii?ii?iaiiy e?ia? iai?ai?ia?aeieeiaei eaca?iei
aia?aoii “Eo/-2” i?e aeiaaeei? oaee? 820 ii ? iiooaeiino? 35 iAo/ni2
i?ioyaii 5-7 aei?a. *aoaa?oo a?oio neeaee 32 oai?eo ia aino?ee
i?neyaai?oiee aiaeiiao?eo, yeei aei caaaeueiii?eeiyoiai e?eoaaiiy
aeiaeaaaany aioa?inaaeue (ii 15 a 3 ?ace ia aeiao per os o i?ii?aeeao
i?ae aaeeaaiiyi ?ae? oa iaaeeeaiaio?a i?ioyaii 5-7 aei?a) o ii?aeiaii? c
/a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia?. I’yoo a?oio noaiiaeee 30
oai?eo aino?ei i?neyiieiaiaei aiaeiiao?eoii, ui e?eoaaeenue
o?aaeeoe?eiei iaoiaeii. A oinoo — aa?eoei 28 oai?eo aino?ei
i?neyiieiaiaei aiaeiiao?eoii, ye? io?eioaaee caaaeueiii?eeiyoo oa?ai?th
oa /a?acnoaeeiia eaca?ia ii?ii?iaiiy e?ia?. Nueiia a?oia — 30 oai?eo ia
aino?ee i?neyiieiaiaee aiaeiiao?eo — io?eioaaea ?ic?iaeaio iaie
eiiieaenio oa?ai?th c aeei?enoaiiyi aioa?inaaey o ii?aeiaii? c
/a?acnoaeeiiei eaca?iei ii?ii?iaiiyi e?ia?. A?oie aoee ?aiaeii?ciaai? ca
a?eii oa aaaee?noth caoai?thaaiiy.

C iaoith ioe?iee aoaeoeaiino? ei?aaoth/i? ae?? aioa?inaaey oa
/a?acnoaeeiiiai eaca?iiai ii?ii?iaiiy e?ia? ia noai IIE, AINC o oai?eo
aino?ei aiaeiiao?eoii, aea/aee iieacieee a?eueii?aaeeeaeueiiai ieeneaiiy
e?i?ae?a (eiioeaio?aoe?th ae??iiaeo eii’thaao?a (AeE), a?ae?iia?aeen?a
e?i?ae?a (AI), iaeiiiaiai aeeaeueaeaa?aeo (IAeA) o ne?iaaooe? e?ia?) oa
aeoeai?noue aioeieneaeaioiiai oa?iaioo — noia?ieneaeaeeniooace (NIAe).
Aeey oa?aeoa?enoeee ?ioiinoeioethth/i? ae?? ?ic?iaeaiiai eiiieaeno
e?eoaaiiy aeine?aeaeoaaee ooieoe?iiaeueiee noai nenoaie aoii?aeueiiai
?ioi?oaoo (eiioeaio?aoe?th ?ioiiaeiaoe?i?a eean?a G, A, I o ne?iaaooe?
e?ia?) oa ianiaoeeo?/io ?acenoaioi?noue i?aai?cio (??aaiue
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) ? e?cioeeio a ne?iaaooe?
e?ia?). I?i ??aaiue aiaeiaaiii? ?ioieneeaoe?? i?aai?cio na?ae/eee
eiioeaio?aoe?? na?aaeiueiiieaeoey?ieo iaioeae?a1, 2 o ne?iaaooe? e?ia?
oa a?eo?ioeeoa?iee ?iaeaen ?ioieneeaoe??.

Caaaeueiiee?i?/i? aiae?ce i?iaiaeeee i?e anooi? ae?iie o noaoe?iia?, a
aeeiai?oe? e?eoaaiiy ? ia?aae aeieneith. ??aaiue aiaeiaaiii?
?ioieneeaoe??, noai IIE, AINC, ?ioiieia?/ii? ?aaeoeaiino? i?aai?cio
aea/aee aei ? i?ney e?eoaaiiy. E?ia a?aee iaoua c e?eoueiai? aaie o
e?eueeino? 8-10 ie. Aecia/aiiy AI i?iaiaeeee ca iaoiaeeeith
E.A.?iiaiiaie, E.Ae.Noaeueiie (1977), AeE — ca iaoiaeeeith
E.Ae.Noaeueiie (1977), IAeA — E.Ae.Noaeueiie, I.A.Aa?eoaeee, aeoeaiino?
NIAe — N.*aaa?e, E.*aaa, E.Naeae (1985), A.A.Aeoaeieiie (1988).

??aaiue na?aaeiueiiieaeoey?ieo iaioeae?a o ne?iaaooe? e?ia? aecia/aee ca
iaoiaeeeith I.E.Aaa?eyeyi, A.I.Eeiaoiaa (1984), a?eo?ioeeoa?iee ?iaeaen
?ioieneeaoe?? — A.A.Oiaaiaaaaa e niaao. (1988).

Eiioeaio?aoe?th ?ioiiaeiaoe?i?a iniiaieo eean?a o ne?iaaooe? e?ia?
aecia/aee ca iaoiaeeeith ?aae?aeueii? ?ioiiaeeooc?? (G. Manc?n? et al.,
1965), ??aaiue Oe?E — iaoiaeii A.E.Iao?iaa (1983), eiioeaio?aoe?th
e?cioeeio — ca iaoiaeeeith O.ss.A?aiaea (1973).

Noaoenoe/io ia?iaeo ?acoeueoao?a aeine?aeaeaiue i?iaiaeeee
aeei?enoiaoth/e no/ani? iaoiaee aa??aoe?eii? noaoenoeee [Ia?eia A.I.,
Iieyeia E.A., 1974; Vessey, 1996] ca aeiiiiiaith i?ia?aie Exel M?crosoft
Off?ce.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. I?iaaaeai?
ee?i?ei-eaai?aoi?i? aeine?aeaeaiiy caei?iaeo iaaaa?oieo ae?iie
oa?oeeueiiai a?eo aeicaieeee anoaiiaeoe ii?iaeuei? iieacieee
na?aaeiueiiieaeoey?ieo iaioeae?a, a?eo?ioeeoa?iiai ?iaeaeno
?ioieneeaoe??, iaoaaie?o?a IIE, iaeiiai c aieiaieo oa?iaio?a AINC —
noia?ieneaeaeeniooace, ?ioiiaeiaoe?i?a A, G, I, oee?eoethth/eo ?ioiieo
eiiieaen?a, e?cioeeio e?ia?, i?e?ioei?e ii?iaeieie iaoee. Ii??aithth/e
io?eiai? ?acoeueoaoe c aeaieie ?ioeo aaoi??a [Aaica? C.O., 1989; Aie/oe,
1989; AEeey?a I.?., 1992; Oi?eue N.A., 1994; Iioiaeoi E.A., 1995;
Caaie?eoeueeee A.A., 1997], ie ia ciaeoee nooo?ai? ??cieoe?.

Aiae?c aeaeiaiai neeaaeo i?e?ioei?e ii?iaeieie iaoee iieacaa, ui na?aae
caoaeiee?a aino?iai i?neyiieiaiaiai aiaeiiao?eoo ia?aaaaea? noao?eieie ?
eeoeiaa iaee/ea. Oe? i?e?ii?aai?cie aeyaeyeenue, ye o aeaeyae?
iiiieoeueoo?e, oae ? a anioe?aoe?yo. Na?aae aeae?eaieo noao?eieie?a
/ano?oa anueiai cono??/aany nai?io?oiee (o 30,2 %), ??aeoa —
ai?aea?iaeueiee (o 20,6 %). Cieioenoee noao?eieie ciaoiaeeany o 7,1 %
aeiaaee?a, eeoeiaa iaee/ea — o 15,1 % niinoa?aaeaiue. Anioe?aoe?y
noao?eieiea ? eeoeiai? iaee/ee aeyaeaia o 15,1 % iaoe??ioie. Aioa?ieiee
aeae?eai? o 7,9 % ae?iie, eeaan??ea — o 4,0 % ianoaaeaieo.

I?e aaeoa??ieia?/iiio aeine?aeaeaii? aeae?eaiue c i?oae o 75 % ae?iie
aeyaeaia eieiaa oei?a, o 23,6 % — o?eoiiiiaaee, o 1,4 % — ae??aeaeaeia?
a?eae.

I?e anooi? o noaoe?iia? o oai?eo aino?ei i?neyiieiaiaei aiaeiiao?eoii
aeyaeaii aeoeaaoe?th i?ioean?a IIE. Eiioeaio?aoe?y AI, IAeA, AeE
aeinoia??ii (p0,05) ciaioaiiy eiioeaio?aoe??
IAeA (5,02 ± 0,43 ieiieue/e); i?ioa aeyaeaii aeinoia??ia (p10,05) ciaioaiiy
eiioeaio?aoe?? na?aaeiueiiieaeoey?ieo iaioeae?a — 1
(317,80 ± 12,70 oi. iae.), na?aaeiueiiieaeoey?ieo iaioeae?a — 2
(459,78 ± 10,12 oi.iae.) oa a?eo?ioeeoa?iiai ?iaeaeno ?ioieneeaoe??
(41,70 ± 2,15 %). Io?eiai? iieacieee nooo?ai (p 0,05

p1 0,05 13,92 ± 0,71

p > 0,05

p1 0,05 4,03 ± 0,23

p 0,05 2,72 ± 0,19

p > 0,05

p1 0,05 11,93 ± 0,68

p > 0,05

p1 0,05 310,25 ± 11,72

p 0,05

p2 > 0,05 186,13 ± 9,32

p > 0,05

p1 0,05 422,19 ± 8,14

p 0,05

p2 > 0,05 310,05 ± 7,16

p > 0,05

p1 0,05 38,97 ± 2,35

p 0,05

p2 > 0,05 27,45 ± 1,97

p > 0,05

p1 0,05 1,97 ± 0,19

p 0,05

p2 > 0,05 2,64 ± 0,16

p > 0,05

p1 0,05 8,06 ± 0,13

p 0,05

p2 > 0,05 9,53 ± 0,13

p > 0,05

p1 0,05 1,49 ± 0,17

p 0,05 0,98 ± 0,15

p > 0,05

p1 0,05 6,07 ± 0,84

p > 0,05

p1 0,05

p1 0,05

E?cioeei

(iea/ie) 9,13 ± 0,97 2,15 ± 0,52

p 0,05 5,68 ± 0,31

p 0,05

p1 0,05) i?aeaeuaiiy eiioeaio?aoe??
?ioiiaeiaoe?io G (7,85 ± 0,20 a/e) oa ?ioiiaeiaoe?io A (1,72 ± 0,19 a/e)
o ne?iaaooe? e?ia?.   ??aaiue   ?ioiiaeiaoe?io I  iacia/ii  (p1>0,05) 
cieaeoaaany  ?  noaiiaea 1,87 ± 0,21 a/e. Eiioeaio?aoe?y Oe?E o
ne?iaaooe? e?ia? i?ney i?iaaaeaiiai e?eoaaiiy o?aaeeoe?eiei iaoiaeii
aeaui (p1>0,05) ciaiooaaeanue ? aei??aithaaea 9,03 ± 1,08 iae. ??aaiue
e?cioeeio ia?aae aeieneith i?aeaeuoaaany aei 3,06 ± 0,51 iea/ie.
Iieacieee A-nenoaie ?ioi?oaoo oa ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio
aeinoia??ii (p0,05)
ciaioaiiy eiioeaio?aoe?? na?aaeiueiiieaeoey?ieo iaioeae?a-1
(310,25 ± 11,72 oi. iae.), na?aaeiueiiieaeoey?ieo iaioeae?a-2
(422,19 ± 8,14 oi. iae.) oa a?eo?ioeeoa?iiai ?iaeaeno ?ioieneeaoe??
(38,97 ± 2,35 %). Io?eiai? iieacieee aoee nooo?ai (p0,05) i?aeaeuaiiy eiioeaio?aoe?? ?ioiiaeiaoe?io G (8,06 ± 0,13 a/e)
oa ?ioiiaeiaoe?io A (1,97 ± 0,19 a/e). ??aaiue ?ioiiaeiaoe?io I iaa
oaiaeaioe?th aei ii?iae?caoe?? (p10,05). Eiioeaio?aoe?y e?cioeeio a ne?iaaooe?
e?ia? ia?aae aeieneith cia/ii (p10,05)
caei?iaeo iaaaa?oieo ae?iie oa?oeeueiiai a?eo (oaae. 2).

I?ney i?iaaaeaiiai e?eoaaiiy oai?eo aino?ei i?neyiieiaiaei aiaeiiao?eoii
eiiieaeniei iaoiaeii eiinoaoiaaii cia/ia (p10,05) aei aiaeia?/ieo — o caei?iaeo iaaaa?oieo ae?iie. Eiioeaio?aoe?y
e?cioeeio o ne?iaaooe? e?ia? i?ney cai?iiiiiaaiiai iaie e?eoaaiiy
aeinoia??ii (p10,05) eiio?ieth. A?aei?/aeanue ia?aae aeieneith oaeiae
ii?iae?caoe?y ??aiy Oe?E o ne?iaaooe? e?ia? (4,93 ± 0,32 iae.) (oaae.
3).

E?ea?aeaoe?y aiaeioieneeico, ii?iae?caoe?y i?ioean?a IIE, iioaioe?aeo
AINC oa ?ioiiiai noaoono i?aai?cio oai?eo a?aeia?aaeaeanue ? ia a?eueo
aeaaii?e?iiiio ee?i?/iiio ia?aa?ao caoai?thaaiiy.

A i?ioean? e?eoaaiiy ia noa’?eoeaia iie?auaiiy aeacoaaee an? ianoaaeai?
ae?iee. Iaeiae oai??, eio?? e?eoaaeenue eiiieaeniei iaoiaeii ?c
aeei?enoaiiyi aioa?inaaey o ii?aeiaii? c /a?acnoaeeiiei eaca?iei
ii?ii?iaiiyi e?ia?, iie?auaiiy naiiii/oooy a?aecia/eee ia 2,26 aeiae
?ai?oa, i?ae iaoe??ioee, ui io?eioaaee o?aaeeoe?eio oa?ai?th. Iano?eueee
ae ae?a aeia?aaeaeaea ? ii?iae?caoe?y oaiia?aoo?e o?ea. A?eue aieco
aeeaioa o ia?oeo ae?iie cieeaa ia 3,10 aeiae ?ai?oa i?ae o ae?oaeo. O
iaoe??ioie, ui io?eioaaee ?ic?iaeaio iaie oa?ai?th, ii?iae?caoe?y
e?eueeino? eaeeioeeo?a, eaeeioeeoa?ii? oi?ioee, oaeaeeino? cn?aeaiiy
a?eo?ioeeo?a a?aeaoaaeanue ia 3,90 aeiae nei??oa, i?ae o oai?eo, ye?
e?eoaaeenue caaaeueiii?eeiyoeie iaoiaeaie (oaae. 4).

I?e e?eoaaii? oaeineiiaeaiith oa?ai??th c aeei?enoaiiyi eeoa
/a?acnoaeeiiiai eaca?iiai ii?ii?iaiiy e?ia? ae?aciiai ee?i?/iiai aoaeoo
ia anoaiiaeaii.

Na?aaeiy o?eaae?noue ia?aaoaaiiy o noaoe?iia?? iaoe??io?a, a eiiieaen
e?eoaaiiy yeeo aeeth/aiee aioa?inaaeue o ii?aeiaii? c /a?acnoaeeiiei
eaca?iei ii?ii?iaiiyi e?ia?, neeaea 8,17 ± 0,58 e?aeei-aei?a ? aoea
aeinoia??ii (p 0,05

2,80 ± 0,11

p1 0,05

4,02 ± 0,17

p1 0,05

6,17 ± 0,31

p1 0,05

8,17 ± 0,58

p1

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