OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

OAA*AIEI Iaoaey Noai?neaa?aia

OAeE 616.71-007.234:616-018.2]-07-053.6

EE?I?EI-IAOIAAIAOE*IA OA?AEOA?ENOEEA INOAIIAI?*IIAI NEIAe?IIO I?E
NENOAIIEO OAI?IAAO NIIEO*II? OEAIEIEO Ae?OAE OA I?AeE?OE?A

14.01.10 — Iaae?ao??y

A A O I ? A O A ? A O

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo? ioi?iie
caei?ia’y ae?oae ? i?aee?oe?a IIC Oe?a?ie, i. Oa?e?a.

Iaoeiaee ea??aiee:Aeieoi? iaaee/ieo iaoe, i?ioani?,

caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,

EINOTH??IA Aaeeia Ieeeo?aia,

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo

ioi?iie caei?ia’y ae?oae ? i?aee?oe?a, i. Oa?e?a,

aieiaiee iaoeiaee ni?a?ia?oiee a?aeae?eo

iaoieia?? i?aee?oe?aIo?oe?ei? iiiiaioe:Aeieoi? iaaee/ieo iaoe, i?ioani?

IAeEIAOeUe TH??e Aaneeueiae/,

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoth/ee eaoaae?ith oaeoeueoaonueei? iaae?ao???

c iaaee/iith aaiaoeeithAeieoi? iaaee/ieo iaoe, i?ioani?

AAUAIEI Ethaeieea Aieiaeeie??aia,

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y,

caa?aeoth/a eaoaae?ith aini?oaeueii? iaae?ao??? ?1.

I?ia?aeia onoaiiaa: ?inoeooo iaae?ao???, aeooa?noaa ? a?iaeieia?? AII
Oe?a?ie, a?aeae?eaiiy aeeoa?aioe?eii? ae?aaiinoeee, i?io?eaeoeee ?
oa?ai?? caoai?thaaiue aioo??oi?o i?aai?a o ae?oae, i.Ee?a.

Caoeno a?aeaoaeaoueny “11” eenoiiaaea 1999 ?. i 12-30 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a, i?. Eai?ia 4).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (i. Oa?e?a, i?. Eai?ia 4).

Aaoi?aoa?ao ?ic?neaiee “ 23 ” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, aeioeaio ________________ Ia/a?aiei E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia nenoaiieo oai?ia ciieo/ii? oeaieie (NONO)
? iaei??th c iaea?eueo aeooaeueieo o aeeoy/?e ? i?aee?oeia?e
?aaiaoieia?? aiane?aeie oyaeeino? ia?aaiao, iie?neiae?iiiino? e
ianeaiinoi aeieeath/eo o?aaeaiue, iiaaeiaeecaoei?, yea oaeaeei ianoa? a
iieiaeiio a?oe? (Ei?ai?a M.I., Einoth?iia A.M., 1996; Ianiiiaa A.O.,
1997; Aaiaeaea ?.I., 1997; Sokka N. et al., 1998). *anoioa ?aaiaoe/ieo
caoai?thaaiue (?C) iino?eii c?inoa?, ? na?aae ieo cia/io ieoiio aaao
iathoue ?aaiaoi?aeiee a?o?eo (?A) ? NONO (A?i?aieainueea E.?.,
A?aeacianueeee I.I., 1988; Eiaaeaiei A.I., 1997; Iiaeue/aiei E.?.,
Aeoaeea ?.A., 1993; Fonseka J.E. et al., 1998; Karaaslan Y. et al.,
1998). Iaae?ioaiinoue ieoaiue ?aiiuei? ae?aaiinoeee, nai??iaeiinoue
ia?aaiao caoai?thaaiue, neeaaei?noue aaeaeaaoiiai aoaiiiai e?eoaaiiy,
iiaeeea?noue iani?eyoeeaeo ianeiaeeia NONO o ae?oae ? i?aee?oe?a
coiiaeai? cia/ieie iae?i-aiaeie?eiieie e ii?oiooieoeiiiaeueieie ci?iaie
a ia??iae? noaoaaiai aeic?iaaiiy, ui ia??aeei i?ecaiaeyoue aei aaaeeiai,
i?ia?aaei?ioiiai ia?aaiao aeaieo oai?ia, ?aiiuei? oyaeei? ?iaae?aeiino?
(Einoth?iia A.M., 1996, 1997; Oieiia?aa I.I., 1997; Rooney M., 1998).
Aei oeueiai /ano i?aia?aoaie aeai?o i?e e?eoaaii? oaeeo oai?eo
caeeoathoueny aetheiei?oeeinoa?i?aee (AE) caaaeyee ?o oaeaee?e
i?ioecaiaeueiie oa iioiinoi?aneaiie ae??. Iaeiae ana a?eueo aeooaeueiith
noa? caaea/a iiia?aaeaeaiiy e e?eoaaiiy iiaeeeaeo iiai/ieo aoaeo?a
AE-oa?aii? aiane?aeie iaiao?aeiino? ?o o?eaaeiai ? aacia?a?aiiai
canoinoaaiiy, ye? ia??aeei iia??oothoue noai oai?eo ? caaaeueiee i?iaiic
iniiaiiai caoai?thaaiiy. ?icaeoie inoaiiaii? (II) i?e ?C a?aeiinyoue aei
iaeiiai c /anoeo ? aenieiiiaae?aeecoth/eo oneeaaeiaiue oa?aii?, yea
i?ecaiaeeoue aei aeieeiaiiy noa?i?aeieo niiiaeeeiiaoie ? eiii?anieieo
ia?aeii?a o?aaoa (Aeiiia Ae.I., 1988; Aeaeaaeea? Ae. ?c niiaaao., 1989;
Eiaaeaiei A.I., 1996, 1998; Iiai?icithe A.A. ?c niiaaao., 1998;
Sambrook P., Jones G., 1995; Mul D. et al., 1998). I?e oeueiio
caeeoathoueny iaae?ioaieie ieoaiiy iioe?aiinoi o?aaeaiue einoeiai?
oeaieie i?e ?C ?, iniaeeai, i?e NONO. Iaaeinoaoiuei aecia/aia
cia/ouinoue oe?eiai ?yaeo /eiiee?a, ui iiaeooue aieeaaoe ia ?icaeoie II
i?e NONO: noaoue ? a?e oai?eo, aeoeai?noue ? o?eaae?noue iaoieiai/iiai
i?ioeano, nenoaiiinoue o?aaeaiue niieo/ii? oeaieie, ?o aca?iica’ycie c
eieaeueieie i?ioeanaie a einoeiaie oeaiei? a?ey iioeiaeaeaieo noaeiaia.
Caeeoathoueny coia?a/eeaeie aeoiee i?i aieea oa?ai?? AE ia i?ioeane
iiia?aeicaoei? e?noie i?e ?C (Ianiiia ?.E. ?c ni?aaao., 1997).

Iacaaaeath/e ia iaaecae/aeio aaaeeea?noue noaio einoeiai? nenoaie a
aeeoy/iio e iiaeeioeiaiio a?oei aeey aeinyaiaiiy iieo einoeiai? iane e
i?io?eaeoeee aeieeiaiiy II ia iiaeaeueoeo aoaiao iioiaaiaco
(Iiai?icithe A.A., 1997), ?niothoue eeoa iiiaeeiie? ?iaioe, i?enay/ai?
aea/aiith noaio einoeiai? oeaieie i?e aeai?e iaoieiai? a ae?oae
(Iiaeue/aiei E.?., Aeoaeea ?.A., 1997; ?iaeiiiiaa N.N. ?c niiaaao.,
1997; Aieiaaiiaa I.TH. ?c niiaaao., 1998; Chesney R.W. et al., 1997;
Mul D. et al., 1998).

Aeuacaaaeaia aecia/eei aea?? iai?yieo aeine?aeaeaiiy noaio eicoeiai?
oeaieie a ae?oae ? i?aee?oe?a, oai?eo ia NONO, oeyoii aea/aiiy ?aii?o
i?iya?a ii?ooaiiy i?ia?aeueii? u?eueiino? e?noee (IUE), i?ia?aeueiiai
iai?io e iaoaaieicio i?aai?/ieo eiiiiiaio?a ciieo/ii? oeaieie, a oaeiae
aecia/aiiy i?noey II a iaoieia?? NONO ? na?aae oneeaaeiaiue AE-oa?aii?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeaia
aeine?aeaeaiiy ? o?aaiaioii iaoeiai-aeine?aeieo ?ia?o “Oaeineiiaeaiiy
iaoiaeia eieoaaiiy iiaeeioeia ?c aeeoocieie caoai?thaaiiyie niieo/ii?
oeaieie ? i?ioieaeoeea oneeaaeiaiue ei?oeeinoa?i?aeii? oa?aii?” (oeo?
oaie: ?I. 1914.0037.96, ? aea?ae. ?a?no?aoe?? 0196U002913) ? “?ic?iaeoe
eeaneoieaoeith, iiai iaoiaee eieoaaiiy, aeiaaiinoeee oa i?ioieaeoeee
inoaiii?icia ?icii? aoiieiai? ia iniiai noai?aieo aenia?oieo nenoai,
eeiii/ieo, aenia?eiaioaeueieo oa iaoiaeieiai/ieo iaa?oiooaaiue” (oeo?
oaie: O. IE95.1, ? aea?ae. ?a?no?aoe?? 0196U000754).

Iaoa ?iaioe. Aaeineiiaeaiiy cania?a ?aiiueiai aeyaeaiiy inoaiiaii? i?e
nenoaiieo oai?iaao niieo/ii? oeaieie a ae?oae ? i?aee?oe?a oeyoii
aeine?aeaeaiiy i?ia?aeueii? u?eueiino? e?noee, iaoaaieicio i?aai?/ieo
eiiiiiaio?a niieo/ii? oeaieie e i?ia?aeueiiai iai?io.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1. Aecia/eoe /anoioo e oa?aeoa? oneeaaeiaiue aetheiei?oeei?aeii? oa?aii?
o i?aee?oe?a i?e nenoaiieo oai?iaao niieo/ii? oeaieie.

2. Aea/eoe i?ia?aeueio u?euei?noue e?noee e /anoioo inoaiiaii? a
i?aee?oe?a, oai?eo ia nenoaii? oai?iae niieo/ii? oeaieie, ca aeaieie
iaeiioioiiii? aani?aoeiiiao?i?.

3. Aeine?aeeoe iai?i i?ia?ae?a oa i?aai?/ieo eiiiiiaio?a niieo/ii?
oeaieie i?e nenoaiieo oai?iaao niieo/ii? oeaieie.

4. Aeaoe ioe?ieo aca?iica’yceo iieaciee?a iai?io i?ia?ae?a ?
niieo/ii-oeaieiieo no?oeoo? ?c ii?ooaiiyie i?ia?aeueii? u?eueiino?
einoeiai? oeaieie a ae?oae oa i?aee?oe?a i?e nenoaiieo oai?iaao
niieo/ii? oeaieie.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Oia?oa anoaiiaeaii /anoioa e
oa?aeoa? II o ae?oae ? i?aee?oe?a ?c NONO, aecia/aiee ?? ca’ycie ?c
o?eaae?noth caoai?thaaiiy, aeoeai?noth ? oyaee?noth ia?aaiao
iaoieiai/iiai i?ioeano. Aianai? iia? aeiiiaiaiiy aei oyaeaiue i?i
iaoiaaiaoe/io nooo?a?noue II o ae?oae ? i?aee?oe?a i?e NONO. Iieacaii,
ui i?e NONO II ? ia o?eueee oneeaaeiaiiyi AE-oa?aii?, a e iaeiei c
iaoiaaiaoe/ieo neiae?iiia iniiaiiai caoai?thaaiiy. Aecia/ai?
aca?iica’ycee ci?i iieaciee?a i?ia?aeueiiai iai?io e iaoaaieicio
i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie (??ai? eaeueoeith e oinoi?o
e?ia?, eoaeii? oinoaoace, oiiae?iioeinoeueoaoia (ON), caaaeueieo
ae?eicai?iiae?eainoeueoao?a (AAAn), aene?aoei? ienei?ieiio), ui
aiaeia?aaeathoue aeeaeio nenoaiiiai o?aaeaiiy niieo/ii? oeaieie, c
?icaeoeii II o ae?oae ? i?aee?oe?a i?e NONO ? ?A. Aeyaeaia aeniea
/anoioa oneeaaeiaiue AE-oa?aii? NONO o ae?oae ? i?aee?oe?a. Noai?aiee
aeai?eoi i?iaiicoaaiiy oneeaaeiaiue, iniiaaiee ia i?e/eiii-iane?aeeiaeo
ca’yceao ia?aaiao iaoieiai/iiai i?ioeano, iniaeeainoae ainoea?aeueieo
o?aaeaiue, o?eaaeino? canoinoaaiiy e aeice AE, ? aenieiiioi?iaoeaiei,
aeicaiey? i?iaiicoaaoe eiia??i?noue aeieeiaiiy oneeaaeiaiue AE-oa?ai??,
o oiio /ene? II, ? a/anii aiineoe ei?aeoei? a eiiieaenia e?eoaaiiy
oai?eo ia NONO.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aecia/ai? iani?eyoeea?
oaeoi?e ?icaeoeo inoaiiaii? i?e NONO ? ?A a ae?oae ? i?aee?oe?a c
aeei?enoaiiyi aeaieo aeaineoiiao?i? oa a?io?i?/ieo iieaciee?a
i?ia?aeueiiai iai?io e iaoaaieicio iniiaieo i?aai?/ieo niieo/iioeaieiieo
no?oeoo?. Cai?iiiiiaai? aeiiiaiaiiy aei e?eoaaiiy oai?eo ?c NONO e
inoaiiaii/iei neiae?iiii. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe aeaeai?
iaoiaee/i? ?aeiiaiaeaoe?? “Eieoaaiiy oa aeeniaina?iee iaaeyae ca
iiaeeioeaie ic nenoaiiei /a?aiiei aia/aeii oa aaia?aeiciaaiei
?aaiaoi?aeiei a?o?eoii” (1995) ? “Aeiaaiinoeea, eieoaaiiy oa
i?ioieaeoeea inoaiiaii/iiai neiae?iio o iiaeeioeia, oai?eo ia nenoaiii
caoai?thaaiiy niieo/ii? oeaieie” (1998), neeaaeaia cayaea ia aeiao?ae c
iiceoeaiei ??oaiiyi ?98084290 a?ae 06.08.1998 ?. ?ic?iaeaiee aeai?eoi
i?iaiico aeicaiey? anoaiiaeoe eiia??i?noue aeieeiaiiy oneeaaeiaiue
AE-oa?ai??, a/anii i?iaiaeeoe i?io?eaeoe/i? caoiaee aeey ?o
iiia?aaeaeaiiy. Caniae ae?aaiinoeee e e?eoaaiiy inoaiiaii/iiai
neiae?iio i?e NONO ai?iaaaeaeai? a ee?i?oe? e iie?ee?i?oe? Oe?a?inueeiai
IAe? ICAeI, a iaeanieo oa i?nueeeo e?ea?iyo Oa?eiaa, Iieoaae,
Aei?i?iiao?ianueea, Eueaiaa, Oa?iiiiey, E?einuee?e ?anioae?eainuee?e
aeeoy/?e e?ea?i?. Ai?iaaaeaeaiiy cai?iiiiiaaieo noai ae?aaiinoeee e
ei?aeoei? eiiieaeniiai e?eoaaiiy ae?oae ? i?aee?oe?a ?c NONO aeicaieeei
?ai?oa aeyaeyoe ii?ooaiiy IUE ? i?iaiaeeoe i?io?eaeoeeo iiaeaeueoeo ci?i
ia aeieeiii/ieo ? aei?aioaaiieiai/ieo noaae?yo.

Iniaenoee aianie caeiaoaa/a. Aaoi? naiino?eii i?iaiaeeea ianoaaeaiiy,
e?eoaaiiy e niinoa?aaeaiiy a aeeiai?oe? oai?eo c on?ia oi?iaie NONO ?
?A, i?iaiaeeea i?aea?? oaiaoe/ieo oai?eo, cae?enieea ?ao?iniaeoeaiee
aiae?c oneeaaeiaiue AE-oa?aii?, iaieiae?ea iaoiaeeeith iaeiioioiiii?
aani?aoeiiiao?i? i?iiaiaai? e?noee, cae?enithaaea i?aeaioiaeo
a?ieia?/ieo ??aeei aei a?io?i?/ieo aeine?aeaeaiue. Aaoi?ii naiino?eii
i?iaaaeai? iaoaioii-?ioi?iaoe?eiee iiooe, aiae?c iaoeiai? e?oa?aoo?e c
aeine?aeaeoaaii? i?iaeaie, noaoenoe/iee aiae?c ?acoeueoao?a
aeaineoiiao?i? eiio?ieueii? a?oie e iaoaiaoe/ia ia?iaea, aiae?c oa
?ioa?i?aoaoe?y io?eiaieo aeaineoiiao?e/ieo ? a?io?i?/ieo ?acoeueoao?a o
aeine?aeaeoaaieo oai?eo, a oaeiae ai?iaaoe?y iaoaiaoe/ii? iiaeae?
i?iaiicoaaiiy oneeaaeiaiue.

Aeine?aeaeaiiy aeaineoiiao?e/ieo iieaciee?a o oai?eo ia NONO ? caei?iaeo
ae?oae ? i?aee?oe?a aeeiiaia ni?eueii ?c ni?a?ia?oieeaie Oa?e?anueeiai
IAe? i?oiiaaei? ? o?aaiaoieiai? ii. i?io. I.?.Neoaiea. Iaoaiaoe/ia
iiaeaethaaiiy e noai?aiiy aeai?eoio i?iaiico oneeaaeiaiue i?iaaaeaii
ni?eueii c eaiaeeaeaoii oiceei-iaoaiaoe/ieo iaoe, aeioeaioii eaoaae?e
aeui? iaoaiaoeee Oa?e?anueeiai aea?aeaaiiai iie?oaoi?/iiai oi?aa?neoaoo
A.I.Iaioeeiaith.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee, aeeeaaeai? a
aeena?oaoe??, aoee iia?aeiieai? ia Ae?oaiio Iaoe?iiaeueiiio Eiia?an?
?aaiaoieiaia Oe?a?ie (Ee?a, 1997); Ae?oa?e ? O?ao?e Oe?a?inueeeo
iaoeiai-i?aeoe/ieo eiioa?aioe?yo “Inoaiii?ic: aiiaeaiiieiaiy, eeiiiea,
aeiaaiinoeea, i?ioieaeoeea oa eieoaaiiy” (Euea?a, 1997, Ee?a, 1999);
Ae?oaiio i?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo
(Oa?iiiieue, 1998), aea ?iaioa aoea iaai?iaeaeaia aeeieiiii ca I i?noea;
Oe?a?inuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? i?iaeaie
?aaiaoe/ieo caoai?thaaiue o ae?oae oa i?aee?oe?a” (Oa?e?a, 1996); VII oa
VIII i?nueeeo iaoeiai-i?aeoe/ieo eiioa?aioe?yo e?ea??a-iaae?ao??a
(Oa?e?a, 1998, 1999); ?a?iiaenueeiio eiia?an? c i?iaeai inoaiii?ico
(Aa?e?i, 1998), a oaeiae ia can?aeaii? Oa?e?anueeiai iaoeiai-iaaee/iiai
oiaa?enoaa aeeoy/eo e?ea??a (1997) ? ?aaiaoieiaia (1999), eiioa?aioe??
iieiaeeo a/aieo Oe?a?inueeiai IAeI ioi?iie caei?ia’y ae?oae oa
i?aee?oe?a (1996).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 20 ?ia?o: 8
aeo?iaeueieo noaoae ? 12 ?ia?o a ca??ieeao, iaoa??aeao ? oacao
aeiiia?aeae eiia?ania, c’?cae?a ? eiioa?aioe?e. O?e noaoo? iioae?eiaai?
aac ni?aaaoi??a.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny ?c anooio,
?icae?e?a “Iaeyae e?oa?aoo?e” ? “Ianya ? iaoiaee aeine?aeaeaiiy”, a
oaeiae o?ueio ?icae?e?a aeanieo aeine?aeaeaiue, aiae?co e ocaaaeueiaiiy
?acoeueoao?a aeine?aeaeaiue, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e.

?iaioa aeeeaaeaia ia 170 noi??ieao ae?oeiaaiiai oaenoo, iethno?iaaia 34
oaaeeoeyie ? 18 iaethieaie, ui neeaaea? 29 noi??iie. Nienie e?oa?aoo?e
i?noeoue 298 aeaea?ae (151 — a?o/eciyieo oa e?a?i NIAe ? 147 —
?iicaiieo) ? neeaaea? 30 noi??iie.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. A aeine?aeaeaiiy aoee aeeth/ai? 246
oai?eo: 173 — ?c NONO, na?aae yeeo o 116 iaa i?noea nenoaiiee /a?aiiee
aia/ae (N*A), o 15 — aea?iaoiiiiceo (AeI), o 18 — neea?iaea?i?y (NAe), o
24 — aoceeeiaee ia?ia?oa?i?o (AI), a oaeiae 73 iaoe??ioe c
aaia?aeiciaaiei aa??aioii ?A, a?aoiaoth/e ?aei?noue iniiaieo
iaoiaaiaoe/ieo iaoai?ci?a ?icaeoeo oeueiai caoai?thaaiiy ?c NONO.
A?oiith ii??aiyiiy i?e aea/aii? IUE aoee 13 oai?eo ?c noaeiaiaith
oi?iith ?A. In?a ae?ii/i? noao? aoei 171, /ieia?/i? — 75. Aei ii/aoeo
caoai?thaaiiy ca a?eii oai?? ?iciiae?eyeeny oaeei /eiii: aei 10 ?ie?a
caiaaeoaeaei 117 i?aee?oe?a, a 11-14 ?ie?a — 102, a 15-18 ?ie?a — 27.
O?eaae?noue caoai?thaaiiy eieeaaeany a?ae 2-3 i?nyoe?a aei 18 ?ie?a.
Aeey aecia/aiiy aeiaaiico oa nooiaiy aeoeaiinoi caiaeueiiai i?ioeano
ii?yae c ee?ii/iei ianoaaeaiiyi oai?iai i?iaiaeeeeny o?aaeeoe?ei?
eaai?aoi?i? aeine?aeaeaiiy e?ia?, ?ioiieiai/ieo iieaciee?a, aecia/aiiy
oyaeeino? o?aaeaiiy ie?ie oa ?o ooieoe?iiaeueiiai noaio. I?e
iaiao?aeiino? oai?ei i?iaiaeeeeny ?aioaaiieiai/ii aeine?aeaeaiiy i?aai?a
a?oaeii? ee?oee, e?noie neaeaoa, o?aaeaieo noaeiaia. Aeey inoaoi/iiai
ae?aaiico aeei?enoiaoaaany noai?aiee iaie ia aac? ?ioi?iaoe?eiiai e
noaoenoe/iiai aiae?c?a aeai?eoi aeeoa?aioe?aeueii? ae?aaiinoeee NONO,
caniiaaiee ia aeaieo aiaiiaco ?icaeoeo caoai?thaaiiy, ee?ii/ieo ?
eaai?aoi?ieo iieacieeao eiaeiiai oai?iai (Einoth?iia A.M. ?c niiaaao.,
1995). Aiae?c ee?ii/ieo i?iya?a, oa?aeoa?o ia?aaiao caoai?thaaiue ?
oneeaaeiaiue oa?aii? i?iaiaeeany ye i?e aaciina?aaeiueiio niinoa?aaeaii?
ca oai?eie a ee?iioe? e eiinoeueoaoeai?e iie?ee?iioe?, oae ?
?ao?iniaeoeaii, ca aeaieie inoi?ie oai?ia i?aee?oe?a, yei e?eoaaeeny a
?inoeooo? i?ioyaii inoaii?o 24 ?ie?a (1974-1998 ?.?.). C aeei?enoaiiyi
nenoaiii-?ioi?iaoe?eiiai e noaoenoe/iiai aiae?c?a, iniiaaieo ia aea/aii?
caeiiii??iinoae iaoiaaiaoe/iiai ?icaeoeo e ee?i?/ieo i?iya?a NONO, a
oaeiae iniaeeainoae ? /anoioe oi?ioaaiiy iia?/ieo aoaeo?a AE-oa?aiii,
i?iaaaeaii iaoaiaoe/ia iiaeaethaaiiy i?iaiico ?icaeoeo oneeaaeiaiue.

Aeey aecia/aiiy ?aii?o ci?i noaio einoeiai? oeaieie o 85 iaoei?io?a aoea
i?iaaaeaia iaeiioioiiia aani?aoeiiiao?iy ia e?noeiaiio aeaineoiiao?i
NK-364 (?00494000 O13) o??ie GAMMA MUVEK, Oai?ueia, a aeenoaeueiiio
aiioici i?iiaiaai? e?noee ia ??ai? 1/20 aeiaaeeie ia?aaeie?//y e o
ae?aoici ia a?aenoai? 1/3 a?ae aeenoaeueiiai noaeiaiaiai e?ioey
i?iiaiaai? e?noee, ui a?aeaeaa? a?aeiia?aeii noai aoa/anoi? oa
eiiiaeoii? einoeiai? oeaieie. Aeaea?aeii aei?iiiithaaiiy aoa icioii I125
c aeoeai?noth 7,4 GBq. Eaeia?oaaiiy i?eeaaeo i?iaiaeeeiny uiaeiy (i?e
eiaeiiio aeeth/aii? a aeaeo?iia?aaeo) ca noaiaea?oiei aoaeiiii. Iioeaea
aei???a ci?noo i?ia?ae?a ? IUE neeaaeaea 1,5%. ?acoeueoaoaie
aeine?aeaeaiiy aoee eicoeiai aeaineoia?aie, a oaeiae ?ic?aoiaai?
aeaeo?iiiith i?ia?aiith i?eeaaeo aaee/eie ai?noo i?ia?ae?a o e?nooe?
(a/ni) e iieacieee i?ia?aeueii? u?eueiino? e?noee (a/ni2).

Aeey ioe?iee io?eiaieo ?acoeueoaoia i?iaiae?ciaai? iieacieee IUE o 585
caei?iaeo ae?oae ? i?aee?oe?a a?ae 4 aei 18 ?ie?a, yei aoee ?iciiae?eai?
ca noaooth ? a?eii. Ii?yae c aaniethoieie iieacieeaie IUE ?ic?aoiaoaaany
ia?aiao? noaiaea?oiiai a?aeoeeaiiy () a?ae io?eiaiiai a eiio?ieuei?e
a?oi? a?eiai-noaoaaiai ii?iaoeao. Aeei?enoiaoth/e eiai cia/aiiy, aoee
aecia/ai? iaaei iieaciee?a MUE aeey aeyaeaiiy iayaiino? o oai?eo
inoaiiaii? oa inoaiii?ico. Ii?iaeueiei aaaaeaeiny cieaeaiiy IUE o iaaeao
iaeiiai noaiaea?oiiai a?aeoeeaiiy. Cieaeaiiy einoeiai? iane — inoaiiaiiy
— ae?aaiinooaaeany i?e cieaeaii? IUE a?eueoa iaeiiai noaiaea?oiiai
a?aeoeeaiiy, aea iaioa aeaio c iieiaeiith. Inoaiii?ic ae?aaiinooaaany
i?e cieaeaii? IUE a?eueoa aeaio c iieiaeiith noaiaea?oieo a?aeoeeaiue
(World Health Organ. Tech. Rep. Ser., 1994).

O oai?eo aea/aany i?ia?aeueiee iai?i e iai?i i?aai?/ieo eiiiiiaio?a
niieo/ii? oeaieie oeyoii aecia/aiiy eiioeaio?aoe?? eaeueoe?th a e?ia? e
na/i eiiieaeniiiiao?e/ieie oeo?oaaiiyie c aeei?enoaiiyi oethi?aeniia ye
?iaeeeaoi?a (Iie?ianueeee A.A., 1969), a oaeiae eiioeaio?aoe?? oinoi?o a
e?ia? e aeiaiaie na/i, aeoeaiinoi eenei? oa eoaeii? oinoaoac c
aeei?enoaiiyi oiioieiaaieo iaoiaeee (Eiea A.A., Eaieoiieia A.N., 1982;
Aa?aneiia A.I., Oo?oeaaa E.I., 1986). Aea/aany ai?no ON o ne?iaaooei
e?ia? ca ?aaeoe??th c ?eaaeiiii (Neooeueeee E.?., Eaina TH.TH., 1975),
noia?ieo AAAc oa ?o o?aeoe?e (Ooa?i I.?., Oeiioaiei I.I.,
Eaiioue?aa O.N., 1982), a oaeiae ??ai?a aeiaiai? aene?aoei? ienei?ieiio
ca M.Ventor ? W.Meng (E?aeue A.A., 1968) e o?iiiaeo eeneio ?c na/ath
(Ia?eo?’?aa ?.A., 1994). Aeey aeine?aeaeaiiy aeei?enoiaoaaeeny aaiicia
e?ia i?ney 12-aiaeeiiiai aieiaeoaaiiy e c?a?aia a oeae aea aeaiue
aeiaiaa na/a.

Noaoenoe/iee aiae?c io?eiaieo aeaieo i?iaiaeeany ca aeiiiiiaith
ia?aiao?e/ieo ? iaia?aiao?e/ieo e?eoa???a. Aeey ioe?iee io?eiaieo
a?io?i?/ieo iieaciee?a aoa i?iaaaeaiee ei?aeyoeieiee aiae?c.
Cae?enithaaeany iiiaeeiia ei?aeyoeiy ia?aiao??a; aecia/aiiy iniiaieo
/eiiee?a, ui aieeaathoue ia ?acoeueoaoe aeine?aeaeaiiy, oeyoii oaaiai?
?aa?ani? oa aeenia?n?eiee aiae?c aeey ioe?iee aieeao ocaaaeueithth/eo
/eiiee?a ia io?eiai? a aeine?aeaeaiiyo iieacieee. Iaoaiaoe/ia ia?iaea
i?iaaaeaia ca aeiiiiiaith i?ia?aie “Statgraphic” ia ia?niiaeueiiio
eiii’thoa?? IBM PC.

?acoeueoaoe aeine?aeaeaiiy. Aea/aiiy eeiii/ieo iniaeeainoae NONO i?e
i?iaaaeaii? ?ao?i- ? i?iniaeoeaiiai aiae?co iieacaei, ui ia no/aniiio
aoai? aeaatho oai?ia aeaii? a?oie i?eoiaeeany ia i?a-, ?aii?e ? aeania
ioaa?oaoiee ia?ioaee. I?e oeueiio ia N*A, AeI ? ia nenoaii? oi?ie ?A
caeaa?eueoa caoai?thaaee ae?a/aoa a ?aiiueiio e aeania ioaa?oaoiiio, ia
AI — oeii/eee a i?aioaa?oaoiiio ia??iae? e ia NAe — iaeiaeiai /anoi
iniae iaio noaoae i?aioaa?oaoiiai a?eo. Aeaatho NONO noi?iaiaeaeoaaany
o?aaeaiiyi oei?e, cia/ieie o?ioi/ieie ci?iaie o aeaeyae? cieaeaiiy iane
o?ea, aeoii/aiiy, aeiaaeiiiy ? eaieinoi aieinny, a oaeiae iayai?noth
noaeiaiaiai neiae?iio e noaeeiieie ii?ooaiiyie. Na?aae ainoea?eoia
iae/ano?oa ?icaeaaeeny ea?aeeo, iao?eo, ioeueiiiio, aaiaoeo, a oaeiae
aaiiiaoiy. I?e oeueiio aeey eiaeii? iicieiai/ii? oi?ie aoee oa?aeoa?i?
aeaye? a?aei?iiino?. I?e N*A iae/ano?oeie aoee ethion-iao?eo (63,17%),
ea?aeeo (49,51%), o?aaeaiiy oeaio?aeueii? ia?aiai? nenoaie (26,21%),
aaiiiaoiy (49,51%); i?e nenoaiiiio ?A — ea?aeeo (81,82%),
aaiaoiei?iaeueiee neiae?ii (72.73%), aaiiiaoiy (54,55%), ci?ie c aieo
ie?ie (27,27%). O an?o oai?eo ia AeI ae?aaiinooaaany aaiaoiei?iaeueiee
neiae?ii, o a?eueoino? — ea?aeeo (66,67%), o iieiaeie iaee i?noea
o?aaeaiiy ia?aiai? cenoaie. O oai?eo c AI iae/ano?oeie neiae?iiaie aoee
ea?aeeo (76,47%), aaiaoeo (76,47%), ioeueiiiio (35,29%), ?iaeoa —
o?aaeaiiy ie?ie (29,41%) e aaaeiiiiaeueiee neiae?ii (23,53%). Ee?ii/ia
ea?oeia NAe a?ae??ciyeany iae/ano?oeie na?aae on?o NONO o?ioi/ieie
(85,71%) e noaeeiieie (71,43%) i?iyaaie, caeo/aiiyi aei iaoieiai/iiai
i?ioeano i’yciai? nenoaie (64,70%) e aenieith /anoioith aaiaoiiaaaei?
(57,14%), ea?ae?aeueieo (28,57%) ? eaaaiaaeo (28,57%) ci?i.

Anoaiiaeaii, ui o a?eueoino? (81,55%) i?aee?oe?a ?c NONO oa
aaia?aeiciaaieie oi?iaie ?A iaee i?noea oneeaaeiaiiy AE-oa?aii?, i?e
oeueiio a a?eueoino? iaoei?io?a a?aecia/aio ii?aeiaiiy aeae?eueeio c ieo
(oaae. 1). Na?aae iia?/ieo aoaeo?a ae?oaa i?noea i?ney eooeiai?aeiiai
neiae?iio ca /anoioith ?icaeoeo caeiaee o?aaeaiiy einoeiai? oeaieie c
o?aooaaiiyi i?iaaaeaiiai aeaineoiiao?e/iiai aeine?aeaeaiiy ? ee?ii/ieo
i?iya?a o aeaeyae? aieueiaiai neiae?iio a ae?eyioe? o?aaoa, ye?
iineethaaeeny i?e o?eaaeiio aa?oeeaeueiiio iieiaeaiii, noaoe/iiio
iaaaioaaeaii?, a oaeiae ae?aaiinoiaaieo ?aioaaiieiai/ii eiii?anieieo
ia?aeii?a o?aaoeia, anaioe/ieo iae?icia aieiaee noaaia. Iaeiaioa /enei
iaaaoeaieo aoaeo?a AE-oa?aii? a?aecia/aeiny a iaoei?io?a, yei
caiaaeoaeaee a i?ciueiio ioaa?oaoiiio ia??iae?, i?e o?eaaeiio
aeei?enoaii? aenieeo i?eaii/oth/eo aeic AE.

Oaaeeoey 1 — *anoioa oneeaaeiaiue aetheiei?oeei?aeii? oa?aii? o
i?aee?oe?a?c nenoaiieie oai?iaaie niieo/ii? oeaieie oa
aaia?ae?ciaaiithoi?iith ?aaiaoi?aeiiai a?o?eoo (%m).

OneeaaeiaiiyN*AOIAeINNAe?AAnueiaiEooeiai?ae76,424,1269,579,8018,1812,191
8,1812,1927,405,2262,503,83Inoaiii?ic62,079,0142,8618,7068,7512,3953,851
3,8368,7511,5956,345,97Ii?ooaiiy
IO40,005,43———31,126,7235,653,65CN?21,052,518,696,019,099,09—50,003,0719
,112,51Naioe/ii22,644,0613,047,18——2,741,9112,452,16I?aeaeuaiiy
AO17,923,734,354,359,099,09—1,371,369,441,92CO?10,371,87———26,032,7014,1
62,28Aeeniaioe/ii9,432,84———4,112,325,571,50A?iceaiee

aano?eo5,662,24———1,371,363,001,12Ineo?/i?0,940,94————0,430,43Oeoe?iaee
ae?aaao3,771,85———1,371,362,150,95ANUeIAI88,683,0886,967,1836,3315,2118,
1812,2068,495,4481,552,54Aaaeeeaa cia/aiiy o aeieeiaii? iia?/ieo aoaeo?a
iaee oaeiae ee?ii/i? iniaeeaino? caoai?thaaiiy, nooi?iue aaia?aeicaoei?
iaoieia?/iiai i?ioeano a eiaeiiai oai?iai oa ?iaeea?aeoaeueia
ia?aiiniinoue AE. Naia aeai? iniaeeaino? aoee iieeaaeai? a iniiao
?ic?iaee aeai?eoio i?iaiicoaaiiy aeieeiaiiy oneeaaeiaiue, ui a?aoiaoaaa
i?e/eiii-iane?aeeia? ca’ycee ia?aaiao caoai?thaaiiy ? iayaiino?
ainoea?aeueieo o?aaeaiue (?en. 1). O?eaae?noue canoinoaaiiy ? aeice AE o
eiaeiiai oai?iai a?aoiaoaaeeny ca aeiiiiiaith ia?ao?aeieo eiao?oe??io?a
?iia??iinoae oneeaaeiaiue caeaaeii a?ae noia?ii? eo?niai? aeice
aetheiei?oeei?aeia. Aeei?enoaiiy ?ic?iaeaiiai aeai?eoio i?iaiico
oneeaaeiaiue aeicaieyei anoaiiaeoe eiia??i?noue aeieeiaiiy oeo aai ?ioeo
iia?/ieo aoaeo?a ia i?aenoaa? oa?aeoa?o ?icaeoeo e ia?aaiao NONO, a
oaeiae c o?aooaaiiyi aeice, caniao e o?eaaeino? aaeeaaiiy AE. Oea
c?iaeei iiaeeeaei ?aii? i?iaaaeaiiy iaiao?aeieo i?io?eaeoe/ieo caoiae?a
uiaei iiia?aaeaeaiiy aeieeiaiiy e i?ia?anoaaiiy oneeaaeiaiue AE-oa?aii?.
Aiae?c ?iaioe i?iiiiiaaiiai aeai?eoio i?iaiico iieacaa, ui ?ic?aoiaai?
i?iaiice ca?aathoueny c oneeaaeiaiiyie ia ??cieo aoaiao caoai?thaaiue o
92,0% aeiaaeeia.

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?yyyy????Word?Microsoft Word??? ???????
HI???u?????????????I???Courier
New?I????-?????????u¤y???????en. 1. Aeai?eoi ?iaeea?aeoaeueiiai
i?iaiico oneeaaeiaiuei?e ei?oeeinoa?i?aeiie oa?aii?.

Anoaiiaeaii, ui i?e NONO o iiaeeioeiaiio a?oei cieaeaiiy iieaciee?a
iiia?aeicaoei? einoeiai? oeaieie a?aeaoaaeiny a?eueoa i?ae o iieiaeie
oai?eo (56,34%) (oaae. 2), ui cia/ii ia?aaeuoaaei ee?ii/io aeyaeai?
ci?ie (17,59%, p<0,001). I?e oeueiio a??ia?aeia cieaeaiiy aaniethoieo iieaciee?a IUE a?aeaoaaeiny i?e an?o iicieiai/ieo oi?iao ye o oai?eo ae?ii/i?, oae ? /ieia?/i? noao?. *anoioa ci?ie aeyaeyeeny a aeenoaeueiiio aiioici i?iiaiaao? e?noee (61,76%) o ii??aiyii? c ae?aoicii (50,72%). Oaeiae naia a aeenoaeueiiio a?aeae?e? o in?a ae?ii/i? noao? a?aecia/ai? a?eueo cia/ii ci?ie, i?ae o in?a /ieia?/i? noao?. Oaaeeoey 2 - *anoioa aeyaeaiiy inoaiiaii? o i?aee?oe?a ?c nenoaiieieoai?iaaie ciieo/ii? oeaieie ? aaia?aeiciaaiith oi?iith?aaiaoi?aeiiai a?o?eoo (%m). A?oie oai?eoAeenoaeueiee a?aeae?eI?ieneiaeueiee a?aeae?eAnueiaiN*A62,969,2944,839,2362,079,01OI42,8618,7042,8618,7042,86 18,70AeI66,6719,2460,0019,9966,6719,24NAe46,1515,0350,0014,4353,8513,83? A78,5710,9762,5012,1068,7511,59An? oai??61,765,8950,726,0256,345,89A??ia?aeieo a?aei?iiinoae nooiaiy II o oai?eo ia ??ciiiai?oi? iicieia?/i? oi?ie NONO ia aeyaeyeiny. Iaeiae ne?ae a?aecia/eoe, ui iaea?eueo? ci?ie aoee o oai?eo c ?A ye o i?ieneiaeueiiio (p<0,05), oae ? a aeenoaeueiiio a?aeae?e? i?iiaiaai? e?noee. ?io? iicieia?/i? oi?ie o ii?yaeeo cieaeaiiy ae?aaeaiino? II ?iciiae?eyeeny oaeei /eiii: AeI, AI, N*A ? NAe. O /anoeie i?aee?oe?a cieaeaiiy IUE ia?aaeuoaaei 2.5 cia/aiiy noaiaea?oiiai a?aeoeeaiiy, ui na?ae/eei i?i iayai?noue o ieo inoaiii?ico. *enei oaeeo oai?eo noaiiaeei i?e N*A 17,24%, NAe - 16,67%, AI - 12,5%. Iaea?eueoa /enei iaoe??io?a c inoaiii?icii aeyaeyeiny i?e nenoaii?e oi?i? ?A (25,00%). Na?aae iaoe??io?a c aeyaeaiei inoaiiai?/iei neiae?iiii a?eueo?noue neeaaeaee iniae ae?ii/i? noao? (73,53% i?ioe 26,47%, p<0,001) a ii??aiyii? c a?oiith oai?eo ?c caa?aaeaiith IUE (a?aeiia?aeii 52,00% i?ioe 48,00%). O a?oi? oai?eo, aea cieaeaiiy IUE aeinyaaei noaio inoaiii?ico, ae?a/aoa neeaaeaee oaeiae a??ia?aeio a?eueo?noue (75,00%, p<0,05). I?e ?ao?iniaeoeaiiio aiae?c? anoaiiaeaii, ui ia?o? i?iyae II o oai?eo ia NONO o aeaeyae? aieueiaiai neiae?iio /ano?oa a ae?eyioe? o?aaoa aeieeaee i?ney canoinoaaiiy AE-oa?ai?? a?eueoa iaeiiai ?ieo. Eiii?an?ei? ia?aeiie o?aaoa c’yaeyeeny ia ae?oaiio-o?aoueiio ?ioe? oai?iae. I?e aeine?aeaeaii? noaio e?noeiai? oeaieie oeyoii iaeiioioiiii? aani?aoe?iiao??? anoaiiaeaii, ui cieaeaiiy aeaineoiiao?e/ieo iieaciee?a, a?aeiia?aeia e?eoa??yi II, aeyaeyeiny aaea ia ia?oiio ?ioe? caoai?thaaiiy o 37,50% oai?eo e o 38,80% - ia ia?oiio ?ioe? e?eoaaiiy AE. ?c ca?eueoaiiyi o?eaaeino? caoai?thaaiiy a?aeaoaaeiny i?ia?anoth/a c?inoaiiy /anoioe aeyaeaiiy cieaeaieo iieaciee?a IUE, ? aei /aoaa?oiai ?ieo oai?iae a ia?aaaaeii? a?eueoino? iaoe??io?a aecia/aeany iayai?noue II aai inoaiii?ico (p<0,05). A caeaaeiino? a?ae o?eaaeino? caoai?thaaiiy e?noeiaa oeaieia ci?ithaaeany i?e ??cieo iicieia?/ieo oi?iao iaiaeiaeiai. I?e N*A, AI ? AeI ca?eueoaiiy o?eaaeino? caoai?thaaiiy noi?iaiaeaeoaaeiny c?inoath/ei ca?eueoaiiyi /anoioe e ae?aaeaiino? II. I?e nenoaiiiio ?A ia a?eueo i?ci?o aoaiao a?aecia/aeiny aeayea cieaeaiiy /anoioe aeyaeaiiy II. ?ioa caeaaei?noue aeyaeyeany i?e NAe, eiee /anoioa II aoea aeinoaoiuei aenieith (60,00%) e i?aeoe/ii ia ci?ithaaeany i?ioyaii a?ae iaeiiai aei i’yoe ?ie?a oai?iae. I?e aiae?c? ee?i?/ieo i?iya?a NONO o i?aee?oe?a c iayai?noth II ? inoaiii?ico aeyaeaii, ui aeaiee noai /ano?oa niinoa??aaany i?e o?ii?/iiio ia?aa?ao caoai?thaaiiy (76,19%), i?ae i?e aino?iio (28,57%, p<0,05) aai i?aeaino?iio (40,00%, p<0,05). I?e nenoaiiiio ?A oai?? c II cono??/aeeny iaeiaeiai /anoi ye i?e oaeaeei-, oae ? i?e iia?eueiii?ia?anoth/iio aa??aio? ia?aa?ao caoai?thaaiiy. A??ia?aeii cia/ouiai aieeao iaeneiaeueii? aeoeaiino? iaoieia?/iiai i?ioeano ia /anoioo aeieeiaiiy cieaeaieo iieaciee?a IUE ia ciaeaeaii. Iaeiae ne?ae a?aecia/eoe, ui i?e ae?oaiio oa o?aoueiio nooiai? aeoeaiino? oai?iae II aeieeaa /ano?oa, i?ae i?e ia?oiio. I?e ?icaeoeo o oai?eo ia NONO ia?eoa?e/ieo neiae?ii?a II iaea?eueo /anoi cono??/aeany ca iayai?noth i’yciaiai (61,54%) e noaeiaiaiai (60,87%). Na?aae a?noea?aeueieo o?aaeaiue II /ano?oa aeyaeyeany i?e ?icaeoeo ie?eiaeo ?iceaae?a, iniaeeai iao?eoo (p<0,05). I?e cieaeaii? IUE o ee?i?/i?e ea?oei? caoai?thaaiiy /ano?oa, i?ae o oai?eo c ii?iaeueieie cia/aiiyie, a?aecia/aeiny ii?aeiaiiy o?ueio a?noea?eo?a (p<0,05), a i?e oaeeo oyaeeeo aa??aioao oai?iae, eiee aoei o?noue ? a?eueoa a?noea?aeueieo o?aaeaiue, o an?o i?aee?oe?a niinoa??aaany inoaiiai?/iee neiae?ii. I?e N*A ? aaia?ae?ciaai?e oi?i? ?A an? oai??, o yeeo caoai?thaaiiy iaei ia?aa?a c ?icaeoeii ioeueiii?oo e iie?na?iceo?a, iaee cieaeai? iieacieee IUE. A?aeia?aaeaiiyi oyaeeino? ia?aa?ao ?A aoei /enei caeo/aieo aei iaoieia?/iiai i?ioeano noaeia?a, ? a iaoe??io?a c aeyaeaiith II iaea i?noea oaiaeaioe?y aei a?eueoiai /enea o?aaeaieo noaeia?a, i?ae o a?oi? oai?eo ?c caa?aaeaiith IUE (10,20 ? 8,53 noaeia?a, p<0,1). I?e oeueiio /anoioa inoaiiai?/iiai neiae?iio aoea cia/ii aeuith i?e o?ao?e ? /aoaa?o?e, i?ae i?e ia?o?e (p<0,01) ? ae?oa?e (p<0,05) noaae?yo ?aioaaiieia?/ieo ci?i. A?aecia/aia caeaaei?noue /anoioe aeieeiaiiy II a?ae a?eo ia ii/aoie caoai?thaaiiy. I?e aeaatho? iaoieia?/iiai i?ioeano a 14 ? a?eueoa ?ie?a o cia/ii? a?eueoino? i?aee?oe?a, a iniiaiiio i?e N*A, inoaiiai?/iee neiae?ii ?icaeaaany /ano?oa (p<0,02). Oaeiae iaaacia/iei o a?aeiioaii? ao?aoe IUE aoa i?aioaa?oaoiee ia??iae, i?e ii/aoeo caoai?thaaiiy o yeiio iaea?eueoa /enei i?aee?oe?a ?c cieaeaieie iieacieeaie IUE a?aecia/aeiny i?e NAe (p<0,05) ? nenoaii?e oi?i? ?A (p<0,05). *anoioa inoaiiai?? c?inoaea a?aeiia?aeii ca?eueoaiith o?eaaeino? canoinoaaiiy AE. Ia aeyaeaii a??ia?aeii cia/oui? caeaaeiino? /anoioe aeieeiaiiy II a?ae aaee/eie i?eai?/oth/i? aeice AE. I?e i?ecia/aii? i?aee?oeai i?ioyaii 6-8 oeaei?a AE o iaeneiaeuei?e aeic? aei 30 ia ia aeiao II aeyaeyeany a 55,00%; aei 40 ia - o 66,67%; iiiaae 40 ia - o 57,14%. I?e oeueiio /anoioa ?? aeyaeaiiy ca?eueooaaeany c ia?inoaiiyi /enea ?ioeo oneeaaeiaiue AE-oa?ai??. I?e aeieeiaii? o?ueio iaaaoeaieo aoaeo?a aiia cia/ii c?inoaea ii??aiyii c oeie aeiaaeeaie, eiee niinoa??aaeany i?i?iaeueia e?euee?noue iia?/ieo yaeu (p<0,05). A i?e aeieeiaii? aaeeeiai /enea oneeaaeiaiue (a?eueoa /ioe?ueio) i?aeoe/ii an? iaoe??ioe iaee cieaeaio e?noeiao u?euei?noue. A?aecia/aii c?inoaiiy aeyaeaiiy II o aeiaaeeao, eiee ?icaeoie eooeiai?aeiiai neiae?iio noi?iaiaeaeoaaany ia o?eueee iaee??iiyi, aea e i?aeaeuaiiyi AO (p<0,001) ? iiyaith cia/ieo nioa ?icoyao (p<0,01). O?eueee o oai?eo c II cono??/aeeny oae? a??ci? oneeaaeiaiiy, ye noa?i?aeiee ae?aaao, eaoa?aeoa, i?aeaeuaia e?iaioi/ea?noue. On? oai?? ?c CO? ? CN?, a iniiaiiio i?e ?A ? AeI, iaee cieaeai? iieacieee IUE. O i?aee?oe?a ?c NONO aeineoue /anoi ?icaeaathoueny oneeaaeiaiiy naii? II. Aiie i?iyaeyeeny niiiaeeeiiao?yie (14,29%), ia?aeiiaie o?aaoa oa ?ioeo e?noie neaeaoa (11,43%), anaioe/ieie iae?icaie aie?aie noaaiiaeo e?noie (5,71%). Aeey aecia/aiiy aieeao AE ia noai e?noeiai? oeaieie o ii??aiyeueiiio aniaeo? aoa i?iaiae?ciaaiee oa?aeoa? ?icaeoeo II o oai?eo ?c ??cieie aa??aioaie ia?aa?ao ?A, a?aoiaoth/e a?aenooi?noue AE-oa?ai?? o aeine?aeaeaieo oai?eo ia noaeiaiao oi?io. *anoioa e ae?aci?noue ao?aoe IUE oeaieie iacaeaaeii a?ae oi?ie caoai?thaaiiy ca?eueooaaeeny ?c ia?inoaiiyi caaaeueii? o?eaaeino? ?A (p<0,02), aeoeaiino? ?aaiaoi?aeiiai i?ioeano, eiai ?aioaaiieia?/ii? noaae?? (p<0,05) oa /enea o?aaeaieo noaeia?a. I?iaaaeai? o /anoeie oai?eo ia NONO ? ?A iiaoi?i? aeine?aeaeaiiy IUE oaeiae na?ae/eee i?i aieea iniaeeainoae ia?aa?ao caoai?thaaiiy ia noai e?noeiai? oeaieie. I?e iiceoeai?e aeeiai?oe? ee?i?/ieo i?iya?a, iacaaaeath/e ia o?eaaea i?eeiaiiy AE, niinoa??aaeiny iie?ioaiiy aeaineoiiao?e/ieo iieaciee?a aai ?o caa?aaeaiiy a iaaeao ii?iaeueieo. Iaaiaee, i?e iani?eyoeeaiio ia?aa?ao oai?iae c o?eaaeith aenieith aeoeai?noth ?ioii-caiaeueiiai i?ioeano a?aei?/aeiny ia?inoaiiy inoaiiai?? ia oii? cieaeaiiy aeiaiai? aeice AE ?, iaa?oue, i?e a?aei?i? ?o. Aeine?aeaeaiiy a?io?i?/ieo ia?aiao??a iieacaei, ui a ae?oae ? i?aee?oe?a, oai?eo ia NONO ? ?A, a?aeaoaathoueny aeeaie? ii?ooaiiy a i?ia?aeueiiio iai?i? oa a iaoaaie?ci? iniiaieo i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie. A?eueoith i??ith oe? ci?ie oa?aeoa?ecoaaee nooi?iue aeoeaiino? i?ioeano. A?aecia/aia cia/oua caeaaei?noue a?io?i?/ieo a?aeoeeaiue a?ae caaaeueii? o?eaaeino? caoai?thaaiiy. Anoaiiaeaii, ui ?c ca?eueoaiiyi o?eaaeino? caoai?thaaiiy ia oii? i?ia?aneaiiai cieaeaiiy IUE i?e NONO ? nenoaiieo aa??aioao ?A a?aeaoaaeiny i?aeaeuaiiy ai?noo eaeueoe?th a ne?iaaooe?, iaea?eueoa i?ney aeaio ?ie?a oai?iae (p<0,05). A?eueo aenie? cia/aiiy eaeueoe?o??? niinoa??aaeeny a iaoe??io?a ia ii/aoeiaeo noaae?yo caoai?thaaiiy (p<0,05), eiee iaoieia?/iee i?ioean iaa iaea?eueo aino?ee ia?aa?a ?c cia/ieie iieacieeaie caiaeueii? aeoeaiino?. Oaeo ae ni?yiiaai?noue iineee e ci?ie cia/aiue eoaeii? oinoaoace - iaeiiai c iniiaieo ia?ea??a II (Ceooeueeee E.E., 1988; Leung K.S., 1993; Garnero H., 1996). Iaeaeuith ?? aeoeai?noue aoea ia ia?oiio ?ioe? caoai?thaaiue, aeae? cieaeoaaeany, ? i?ney aeaio ?ie?a aiia aoea cia/ii iaioith (p<0,05). Iieacieee eenei? oinoaoace a on?o a?oiao oai?eo caa??aaeeny i?aeaeuaieie ? ia caeaaeaee a?ae o?eaaeino? NONO. Aeeiai?ea ienei?ie?io na/? oa?aeoa?ecoaaeany iaeiaioeie cia/aiiyie eiai aene?aoe?? ia i?ioyc? a?ae ae?oaiai aei i’yoiai ?ie?a oai?iae (p<0,01), i?e a?eueo aenieiio ??ai? eiai aene?aoe?? ia ?aii?o aoaiao. I?e iiaeaeueoiio ca?eueoaii? o?eaaeino? oai?iae ciia a?aeaoaaeiny c?inoaiiy aeaiiai iieacieea. Ai/aaeaeue, a?eueo aenie? cia/aiiy ienei?ie?io ia ii/aoeiaeo aoaiao caoai?thaaiiy a?eueoith i??ith coiiaeai? caaaeueiith aeoeai?noth iaoieia?/iiai i?ioeano, a a iiaeaeueoiio - aaciina?aaeiuei ?icaeoeii inoaiiai??. C? ca?eueoaiiyi o?eaaeino? oai?iae ?, a?aeiia?aeii, c?inoaiiyi /anoioe ? ae?aaeaiino? inoaiiai?? o ae?oae ? i?aee?oe?a, a?aeaoaaeeny cia/i? ci?ie iieaciee?a ON. ?o ai?no a e?ia? aoa i?aeaeuaiei o ii??aiyii? c ii?iith o an?o oai?eo, iaeiae i?ney aeai??/ii? o?eaaeino? iniiaiiai caoai?thaaiiy niinoa??aaeiny ca?eueoaiiy ?o eiioeaio?aoe?? a e?ia?, ui iiaeia iia’ycaoe ?c ca?eueoaiiyi i??e inoaiiai??. Caeaaei?noue a?io?i?/ieo iieaciee?a, ui ? o?aaeeoe?eieie ia?ea?aie inoaiii?ico, a?ae nooiaiy aeoeaiino? iniiaiiai caoai?thaaiiy aeicaiey? aaaaeaoe, ui ci?ie e?noeiai? oeaieie i?e NONO ? ?A a?aeia?aaeathoue aeeaeio nenoaiiiai o?aaeaiiy niieo/ii? oeaieie, ui na?ae/eoue a iaai?e i??? i?i cia/ou?noue ?icaeoeo inoaiiai?? a iaoiaaiac? aeaii? iaoieia??. Ca’ycie a?io?i?/ieo ia?aiao??a, ui a?aeaeaathoue nooi?iue aeoeaiino? iaoieia?/iiai i?ioeano, ia noai e?noeiai? oeaieie aoa i?aeoaa?aeaeaiee ?acoeueoaoaie ?aa?an?eiiai aiae?co. O a?oi? oai?eo ?c caa?aaeaiith i?ia?aeueiith u?euei?noth iieacieee IUE a aeenoaeueieo a?aeae?eao aoee ca’ycai? c ??aiyie e?aaoei?io (p<0,01), ON (p<0,01) ? caaaeueieo AAAn (p<0,05), a i?ieneiaeueieo a?aeae?eao i?iiaiaai? e?noee - c ??aiyie oinoaoai?? (p<0,001), eaeueoe??i?? (p<0,02), e?aaoei?io e?ia? (p<0,002), ON (p<0,001), eenei? oinoaoace (p<0,001) oa aene?aoe?? o?iiiaeo eeneio (p<0,001). O a?oi? ae?oae oa i?aee?oe?a c inoaiiai?/iei neiae?iiii iani?eyoeeaeie a i?iaiinoe/iiio a?aeiioaii? /eiieeaie aeey aeieeiaiiy inoaiiai?? aoee iieacieee aeoeaiino? eoaeii? oinoaoace (p<0,005), ??aiy caaaeueieo AAAn (p<0,05) ? ienei?ie?io (p=0,05). Caeaaei?noue noaio e?noeiai? oeaieie a?ae aeoeaiino? caiaeueiiai i?ioeano i?aeoaa?aeeee oaeiae ?acoeueoaoe i?iaaaeaiiai aeenia?n?eiiai aiae?co, ui iieacaee aieea nooiaiy aeoeaiino? iniiaiiai caoai?thaaiiy ia ??aaiue inoaiiai?? a aeenoaeueieo a?aeae?eao i?iiaiaai? e?noee (p<0,01). Oaeei /eiii, io?eiai? ?acoeueoaoe aeine?aeaeaiue ? anoaiiaeai? iniaeeaino? i?iya?a inoaiiai?? o oai?eo ia ??ci? oi?ie ?A ? NAe, a e?eoaaii? yeeo ia canoiniaoaaee AE; cai?ioi?noue aeyaeaieo ii?ooaiue IUE i?e ??ciiiai?oieo ee?i?/ieo aa??aioao ia?aa?ao NONO iaaeaei i?aenoaao ?icaeyaeaoe inoaiiai?th ye iaoiaaiaoe/ii coiiaeaio nenoaiiei o?aaeaiiyi niieo/ii? oeaieie ci?io a i?aai?ci?. Oea i?aeoaa?aeaeoaaeiny ? aeeiai?eith aeaineoiiao?e/ieo iieaciee?a i?e o?eaaeiio niinoa?aaeaii?, i?ieea?noth aeine?aeaeoaaieo ia?aiao??a; oa?aeoa?ii ci?i a?io?i?/ieo iieaciee?a iai?io i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie e i?ia?ae?a. Ana oea na?ae/eoue i?i iayai?noue inoaiiai?/iiai neiae?iio i?e NONO ? ?A a i?aee?oeiaiio a?oe?. Canoinoaaiiy AE, ui ? i?aia?aoaie aeai?o a e?eoaaii? aeaii? iaoieia??, iineeth? i?ioeane ao?aoe IUE. AENIIAEE 1.  Anoaiiaeaii, ui i?e nenoaiieo oai?iaao niieo/ii? oeaieie a aeeoy/iio e i?aee?oeiaiio a?oe? a?aeaoaa?oueny cieaeaiiy iieaciee?a i?ia?ae?caoe?? e?noeiai? oeaieie a?eueoa i?ae o iieiaeie oai?eo (56,34%), ui cia/ii ia?aaeuo? aeyaeai? ee?i?/i? e ?aioaaiieia?/i? ci?ie (p<0,001). 2. Cieaeaiiy i?ia?aeueii? u?eueiino? e?noeiai? oeaieie aecia/a?oueny /ano?oa a aeenoaeueiiio ai?o?c?, i?ae a ae?ao?c? i?iiaiaai? e?noee, a in?a ae?ii/i? noao?, i?e aeaatho? caoai?thaaiiy o aeania oa i?ciueiio ioaa?oaoiiio ia??iaeao noaoaaiai aeic??aaiiy, i?e an?o iicieia?/ieo oi?iao nenoaiieo oai?ia niieo/ii? oeaieie. 3.  Aeyaeai? ii?ooaiiy a i?ia?aeueiiio iai?i? e a iaoaaie?ci? i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie coiiaeai? aeoeai?noth iniiaiiai iaoieia?/iiai i?ioeano. I?aeaeuaiiy ??ai?a oinoi?o e?ia?, oiiae?i?oeinoeueoao?a, noia?ieo ae?eicai?iiae?eainoeueoao?a, e?aaoei?io, aene?aoe?? o?iiiaeo eeneio e aeoeaiino? eenei? oinoaoace, a oaeiae cieaeaiiy ai?noo eaeueoe?th a e?ia? ? iani?eyoeeaeie iciaeaie uiaei ?icaeoeo inoaiiai??. Aeyaeaiiy ia oeueiio oii? aenieeo ??ai?a eoaeii? oinoaoace oa aene?aoe?? ienei?ie?io iiaea na?ae/eoe i?i iayai?noue o oaeeo oai?eo inoaiiai?/iiai neiae?iio. 4. I?e nenoaiieo caoai?thaaiiyo niieo/ii? oeaieie o?eaaea aacia?a?aia oa?ai?y aetheiei?oeei?aeaie i?ecaiaeeoue aei ?icaeoeo o a?eueoino? (81,55%) ae?oae ? i?aee?oe?a iia?/ieo aoaeo?a, a oiio /ene? e inoaiiai??. *anoioa oneeaaeiaiue c?inoa? ?c ca?eueoaiiyi o?eaaeino? canoinoaaiiy aetheiei?oeei?aeieo ai?iii?a. 5.  Caeaaei?noue /anoioe ? nooiaiy ae?aaeaiino? inoaiiai?? a?ae o?eaaeino? caoai?thaaiiy, a?eo aeaathoo oai?iae, iniaeeainoae ee?i?/ieo i?iya?a ? ii?ooaiue iaoaaie?cio niieo/iioeaieiieo no?oeoo? na?ae/eoue i?i iiaeeeaee iaoiaaiaoe/iee ca’ycie aeaiiai neiae?iio c iniiaiei caoai?thaaiiyi, a ia o?eueee ?c canoinoaaiiyi aetheiei?oeeinoa?i?aeieo ai?iii?a. 6.  ?ic?iaeaiee aeniei?ioi?iaoeaiee aeai?eoi i?iaiico oneeaaeiaiue aetheiei?oeei?aeii? oa?ai??, o oiio /ene? inoaiiai??. ?ic?aoiaai? i?iaiice ca?aathoueny c oneeaaeiaiiyie ia ??cieo aoaiao ia?aa?ao caoai?thaaiue o 92,0% aeiaaee?a. I?AEOE*I? ?AEIIAIAeAOe?? 1. I?e aaaeeeo ee?i?/ieo aa??aioao nenoaiieo caoai?thaaiue niieo/ii? oeaieie c aenieei nooiaiai aeoeaiino? iaoieia?/iiai i?ioeano, cia/ieo i?aaiieo o?aaeaiiyo, o oiio /ene? i?e ?icaeoeo na?iceo?a, ioeueiii?oo, iao?eoo e i?e aeieeiaii? cia/ieo o?io?/ieo ?iceaae?a, noaeiaiaiai oa i’yciaiai neiae?ii?a, a oaeiae iiiaeeiiiio aoyaiaii? a i?ioean noaeia?a i?e ?aaiaoi?aeiiio a?o?eo? ne?ae i?eioneaoe iiaeeea?noue ?icaeoeo a i?aee?oe?a inoaiiai?/iiai neiae?iio. 2. Aeey ?aiiueiai aeyaeaiiy inoaiiai?/iiai neiae?iio ne?ae aeei?enoiaoaaoe caniae e?noeiai? aeaineoiiao??? (iaeiioioiiia aani?aoe?iiao??y), yea aeicaiey? aeyaeoe ci?ie ia aeiee?i?/i?e ? aei?aioaaiieia?/i?e noaae?yo, ? a?io?i?/i? aeine?aeaeaiiy iai?io i?ia?ae?a oa i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie. I?aeaeuaiiy ??ai?a oinoi?o e?ia?, oiiae?i?oeinoeueoao?a, e?aaoei?io, aene?aoe?? o?iiiaeo eeneio ? aeoeaiino? eenei? oinoaoace, a oaeiae cieaeaiiy ai?noo eaeueoe?th a e?ia? iiaeooue aooe iani?eyoeeaeie iciaeaie uiaei ?icaeoeo inoaiiai??. Aecia/aiiy ia oeueiio oii? aenieeo ??ai?a eoaeii? oinoaoace oa aene?aoe?? ienei?ie?io iiaea na?ae/eoe i?i iayai?noue o oaeeo oai?eo inoaiiai?/iiai neiae?iio. 3. Aeey iiia?aaeaeaiiy aeieeiaiiy cia/ii? inoaiiai?? oa i?io?eaeoeee ?? oneeaaeiaiue ne?ae ?ai?oa (ia i?ci?oa ae?oaiai-o?aoueiai i?nyoey e?eoaaiiy aetheiei?oeei?aeaie) aeeth/aoe aei oa?aiaaoe/iiai eiiieaeno caoiae?a, ye? ni?yiiaai? ia caa?aaeaiiy e?noeiai? iane. ?aeiiaiaeothoueny ae??oa c i?aeaeuaiei ai?noii i?iaeoeo?a, aaaaoeo ia eaeueoe?e, ? aeinoaoi?i ??aiai a?eea (iieiei e iiei/i? i?iaeoeoe, i’yni, oaa?ae? ne?e, yeoey, aiaia?, ?eaa, ai??oe); eiiieaen o?ce/ieo ai?aa aeey ci?oeiaiiy i’yciaiai ei?naoa, ii/eiath/e c ai?aa o e?aeeo; i?ecia/aiiy i?aia?ao?a eaeueoe?th (eaeoao, ea?aiiao, ae?oea?ioinoao, aeoa?iiao eaeueoe?th, “Eaeueoeaa?oa”, “Eaeueoe?iiaa”,“Eaeueoe?e-Ae3-i?eiiaae”, “Eaeueoe?e-naiaeic”) oa iaoaaie?o?a a?oai?io Ae (aeueoa-Ae3, oieaeaeueoeeoa?ie, a?aea?i). I?aee?oeai iieacaia i?ecia/aiiy inoaio?io ia oii? io?eiaiiy aenieeo aeic aetheiei?oeei?ae?a, a i?ney oeueiai canoinoaaiiy eiai eo?naie ia oii? i?aeo?eioth/eo aeic i?ae eiio?ieai noaio i?ia?aeueii? u?eueiino? e?noee. IA?AE?E I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Oaa/aiei I.N. Inoaiiaiiy o aeioae oa iiaeeioeia, oai?eo ia neea?iaea?iith //Iaaeiao?iy, aeooa?noai oa aiiaeieiaiy.- 1999.- ? 1.- N.12-15. 2. Einoth??ia A.I., Oaa/aiei I.N. Iniaeeaino? i?iya?a inoaiiai?/iiai neiae?iio o ae?oae oa i?aee?oe?a c ??cieie oi?iaie ?aaiaoi?aeiiai a?o?eoo //Iaaeiao?iy, aeooa?noai oa aiiaeieiaiy.- 1999.- ? 2.- N.23-27. 3. Aeaaeoo I.A., Oaa/aiei I.N., Oaa/aiei N.Ae., A?iae O.A., Nieeeioeia O.A. Ninoiyiea einoiie oeaie o aeaoae e iiae?inoeia ii aeaiiui iaeiioioiiiie aeaineoiiao?ee //I?oiiaaeey, o?aaiaoieiaey e i?ioace?iaaiea.- 1999.- ?1.- N.13-16. 4. Iiai?icithe A.A., Aaeei A.A., ?aoooaiei I.I, Oaa/aiei I.N. Ai?aeai?ieia?y, ae?aaiinoeea ? e?eoaaiiy inoaiii?ico (ca iaoa??aeaie ?a?iiaenueeiai eiia?ano c i?iaeai inoaiii?ico, I?ia//eia, 11-15 aa?aniy 1998 ?.) //Oe?a?inueeee iaaee/iee /aniien.- 1999.- N2.- N.110-117. 5. Oaa/aiei I.N. Oa?aeoa?enoeea inoaiii?ica o aeaoae e iiae?inoeia n aeeooociuie caaieaaaieyie niaaeeieoaeueiie oeaie //I?iaeaie inoaieia??.- 1998.- O.1, ?1.- N.30-35. 6. Oaa/aiei I.N., Einoth?eia A.I. *anoioa e oa?aeoa? inoaiiaiee o iiae?inoeia n nenoaiiie e?aniie aie/aieie //Aeaoneay ?aaiaoieiaey.- 1997.- ?3.- N.10-16. 7. Einoth?eia A.I., Eaaaoe E.N., Oaa/aiei I.N., Oeiioaaaa I.I., Iineaeaaa I.A., ?ae E.E., Aaaaoeeay I.A. Ineiaeiaiey ei?oeeinoa?ieaeiie oa?aiee o iiae?inoeia n aeeooociuie aieaciyie niaaeeieoaeueiie oeaie //Aeaoneay ?aaiaoieiaey.- 1997.- ?4.- N.9-14. 8. Iiai?icithe A.A., Aaoooaiei I.A., Oaa/aiei I.N. Yieaeaieieiaey, aeeaaiinoeea e ea/aiea inoaiii?ica (ii iaoa?eaeai Aa?iiaeneiai eiia?anna ii i?iaeaiai inoaiii?ica) //Iia. iaoee e oaoi. Na?.Iaaeeoeeia, aui. Aa?iioie.Aa?eao?. - I.:AEIEOE, 1998.- N 6.- N.1-14. 9. Oaa/aiei I.N. Iiai/iua yooaeou aetheiei?oeeieaeiie oa?aiee o iiae?inoeia n nenoaiiie e?aniie aie/aieie //Iaaeeoeeia naaiaeiy e caao?a. Ia?eiae. na. ?aaio iieiaeuo o/aiuo e niaoeeaeenoia.- 1997.- Aui.2.- N.97-99. 10. Aeaaeoo I.A., Iaeuoeeia N.A., Oaa/aiei I.N. Ieia?aeueiay ieioiinoue einoae o aeeoaeae Oa?ueeiaa e Oa?ueeianeie iaeanoe //Ca. iao. I Oe?. iaoeiai-i?aeo. eiio. “Inoaiii?ic: aiiaeaiiieiaiy, eeiiiea, aeiaaiinoeea, i?ioieaeoeea oa eieoaaiiy”.- Ee?a, 1995.- N.22-23. 11. Oaa/aiei I.N. Ninoiyiea ieia?aeueiie ieioiinoe einoiie oeaie o aeaoae e iiae?inoeia n aeeooociuie caaieaaaieyie niaaeeieoaeueiie oeaie //Iao. iaoeiai-i?aeo. eiio. “Aeooaeueii i?iaeaie ?aaiaoe/ieo caoai?thaaiue o aeioae oa iiaeeioeia”.- Oa?e?a, 1996.- N.111-113. 12. Oaa/aiei I.N. E aii?ino ?aiiaai auyaeaiey inoaiii?ica o iiae?inoeia, aieueiuo nenoaiiie e?aniie aie/aieie //Oace aeiiia. I Iiaeia?iae. iaaee/. eiia?ano nooaeaioia oa iieiaeeo a/aieo.- Oa?iiiieue, 1997.- N.104. 13. Oaa/aiei I.N. Inoaiii?ic o iiae?inoeia n thaaieeueiui ?aaiaoieaeiui a?o?eoii //Oac. aeiee. iao/.-i?aeo. eiio. “Ianoiyuaa e aoaeouaa einoiie iaoieiaee”.- Iineaa, 1997.- N.131-132. 14. Oaa/aiei I.N. Inoaiii?ic i?e ?acee/iuo oi?iao thaaieeueiiai ?aaiaoieaeiiai a?o?eoa o aeaoae e iiae?inoeia //Ca. iao. II iaoe.-i?aeo. eiio. “Inoaiii?ic: aiiaeaiiieiaiy, eeiiiea, aeiaaiinoeea, i?ioieaeoeea oa eieoaaiiy”.- Eueaia, 1997.- N.150-151. 15. Einoth?eia A.I., ?ae E.E., Oaa/aiei I.N. e ae?. Ea/aiea iiae?inoeia, aieueiuo nenoaiiie e?aniie aie/aieie e i?iaiice?iaaiea aa enoiaeia //Oac. aeiee. II Nuacaea ?aaiaoieiaia ?innee.- Ooea, 1997.- N.94-95. 16. Oaa/aiei I.N., Ae?aeoo I.A. ?aiiy aeiaaiinoeea ii?ooaiue uieueiinoi einoeiai? oeaieie o iiaeeioeia ic aeeoocieie caoai?thaaiiyie niieo/ii? oeaieie ca aeaieie oioiiii? aani?aoeiiiao?i? //Iao. II Iaoeiiiaeueiiai Eiia?ano ?aaiaoieiaia Oe?a?ie.- Ee?a, 1997.- N.46- 47. 17. Oaa/aiei I.N., Eaiioue?aa O.N. Eeiiiei-aiioiii/ia oa?aeoa?enoeea inoaiii?ico o aeioae oa iiaeeioeia ic aeeoocieie caoai?thaaiiyie niieo/ii? oeaieie //Iao. II Iaoeiiiaeueiiai Eiia?ano ?aaiaoieiaia Oe?a?ie.- Ee?a, 1997.- N.47. 18. Nieeeioeia O.A., Aaeaaaa I.A., A?iae O.A., Oaa/aiei I.N. Niaea?aeaiea ieia?aeia e ieia?aeueiie ieioiinoe einoiie oeaie o aeaoae e iiae?inoeia //Oac. aeiee. e eaeoeee II Ana?inneeneiai Neiiiceoia ii inoaiii?ico.- Aeaoa?eiao?a, 1997.- N.132-133. 19. Shevchenko N.S. Osteopenia syndrome in adolescents with systemic lupus erythematosus /Abstracts of European Congress on osteoporosis, September 11-15, 1998, Berlin //Osteoporosis Int.- Vol.8, Suppl.3.- 1998.- P.140. 20. Oaa/aiei I.N. Eeeieei-?aioaaiieiae/aneea i?iyaeaiey inoaiiaiee o iiae?inoeia i?e aeeooociuo aieaciyo niaaeeieoaeueiie oeaie /Iaoa?. III iaoe.-i?aeo. eiio. “Inoaiii?ic: aiiaeaiiieiaiy, eeiiiea, aeiaaiinoeea, i?ioieaeoeea oa eieoaaiiy” //I?iaeaie inoaieia??.- 1999.- O.2, ?1.- N.98. AIIOAOe?ss Oaa/aiei I.N. Ee?i?ei-iaoiaaiaoe/ia oa?aeoa?enoeea inoaiiai?/iiai neiae?iio i?e nenoaiieo oai?iaao niieo/ii? oeaieie o ae?oae ? i?aee?oe?a. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth: 14.01.10 - iaae?ao??y, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?y i?enay/aia aea/aiith noaio e?noeiai? oeaieie i?e NONO o ae?oae ? i?aee?oe?a oeyoii aeine?aeaeaiiy IUE iaoiaeii iaeiioioiiii? aani?aoe?iiao???, iaoaaie?cio i?aai?/ieo eiiiiiaio?a niieo/ii? oeaieie ? i?ia?aeueiiai iai?io, a oaeiae aecia/aiith i?noey II o iaoieia?? NONO ? na?aae oneeaaeiaiue AE-oa?ai??. Anoaiiaeaii, ui o a?eueoino? (81,55%) oai?eo aeieeathoue oneeaaeiaiiy oa?ai??, a oiio /ene? inoaiiai?y. Cieaeaiiy iieaciee?a IUE a?aeaoaa?oueny o 56,34% oai?eo, ui cia/ii ia?aaeuo? ee?i?/ii aeyaeai? ci?ie (p<0,001), i?e an?o iicieia?/ieo oi?iao, /ano?oa a aeenoaeueiiio a?aeae?e? i?iiaiaai? e?noee i?ae o i?ieneiaeueiiio, a oai?eo ae?ii/i? noao?. *anoioa ? nooi?iue II c?inoathoue ?c ca?eueoaiiyi o?eaaeino? caoai?thaaiiy e canoinoaaiiy AE, i?e oyaeeeo ee?i?/ieo aa??aioao, cia/ieo i?aaiieo o?aaeaiiyo, iniaeeai ie?ie, ? iiiaeeiiiio o?aaeaii? noaeia?a i?e ?A. Iieacaii, ui inoaiiai?y ? iaoiaaiaoe/ii coiiaeaiith ci?iith i?e NONO ? ?A a i?aee?oeiaiio a?oe?. Anoaiiaeaii, ui i?aeaeuaiiy ??ai?a oinoi?o e?ia?, ON, noia?ieo AAAn, e?aaoei?io, aene?aoe?? o?iiiaeo eeneio ? aeoeaiino? eenei? oinoaoace, a oaeiae cieaeaiiy ai?noo eaeueoe?th a e?ia? ? iani?eyoeeaeie iciaeaie uiaei ?icaeoeo inoaiiai??. Aenie? ??ai? eoaeii? oinoaoace ? aene?aoe?? ienei?ie?io na?ae/aoue i?i iayai?noue inoaiiai?/iiai neiae?iio. ?ic?iaeaiee aeniei?ioi?iaoeaiee aeai?eoi i?iaiico oneeaaeiaiue, a oiio /ene? inoaiiai??, aeicaiey? i?iaiicoaaoe ?iia??i?noue aeieeiaiiy iia?/ieo aoaeo?a oa?ai?? ? a/anii aiineoe ei?aeoei? aei eiiieaeniiai e?eoaaiiy oai?eo ia NONO. Eeth/ia? neiaa: ae?oe, i?aee?oee, nenoaii? oai?iae niieo/ii? oeaieie, inoaiiai?y, i?ia?aeueia u?euei?noue e?noee, iai?i, i?aai?/i? no?oeoo?e niieo/ii? oeaieie. AIIIOAOeEss Oaa/aiei I.N. Eeeieei-iaoiaaiaoe/aneay oa?aeoa?enoeea inoaiiaie/aneiai neiae?iia i?e nenoaiiuo aieaciyo niaaeeieoaeueiie oeaie o aeaoae e iiae?inoeia. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 - iaaeeao?ey, Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Oeaeueth ?aaiou yaeeinue niaa?oainoaiaaiea iaoiaeia ?aiiaai auyaeaiey inoaiiaiee i?e nenoaiiuo aieaciyo niaaeeieoaeueiie oeaie (NANO) o aeaoae e iiae?inoeia iooai enneaaeiaaiey ieia?aeueiie ieioiinoe einoe (IIE), iaoaaieecia i?aaie/aneeo eiiiiiaioia niaaeeieoaeueiie oeaie e ieia?aeueiiai iaiaia. A enneaaeiaaiea auee aeeth/aiu 246 aieueiuo: 116 - n nenoaiiie e?aniie aie/aieie, 15 - n aea?iaoiieiceoii, 18 - ni neea?iaea?ieae, 24 - n ocaeeiaui ia?ea?oa?eeoii, 73 - n aaia?aeeciaaiiui aa?eaioii ?aaiaoieaeiiai a?o?eoa (?A). A?oiiie n?aaiaiey auee 13 aieueiuo nonoaaiie oi?iie ?A. Eeoe aeaineiai iiea auei 171, ioaeneiai - 75. E ia/aeo caaieaaaiey ii aic?anoo aieueiua ?ani?aaeaeyeenue neaaeothuei ia?acii: aei 10 eao caaieaei 117 iiae?inoeia, a 11-14 eao - 102, 15-18 eao - 27. Aeeeoaeueiinoue caaieaaaiey eieaaaeanue io 2-3 ianyoeaa aei 18 eao. Aeeaaiinoeea NANO inouanoaeyeanue a niioaaonoaee n iauai?eiyouie e?eoa?eyie e eeanneoeeaoeeyie, a oaeaea ?ac?aaioaiiui aeai?eoiii aeeooa?aioeeaeueiie aeeaaiinoeee NANO. Aiaeec eeeie/aneeo i?iyaeaiee e oa?aeoa?a oa/aiey caaieaaaiee, a oaeaea ineiaeiaiee i?iaiaeeiie oa?aiee i?iaiaeeeny eae i?e iaiin?aaenoaaiiii iaaethaeaiee ca aieueiuie a eeeieea e eiinoeueoaoeaiie iieeeeeieea, oae e ?ao?iniaeoeaii, ii aeaiiui enoi?ee aieaciae iiae?inoeia, iaoiaeeaoeony ia ea/aiee a einoeoooa a oa/aiea iineaaeieo 24 eao (1974-1998 a.a.). N eniieueciaaieai nenoaiii-eioi?iaoeeiiiiai e noaoenoe/aneiai aiaeecia, iniiaaiiiai ia eco/aiee caeiiiia?iinoae iaoiaaiaoe/aneiai ?acaeoey e eeeie/aneeo i?iyaeaiee NANO, a oaeaea iniaaiiinoae e /anoiou oi?ie?iaaiey iiai/iuo yooaeoia AE-oa?aiee i?iaaaeaii iaoaiaoe/aneia iiaeaee?iaaiea i?iaiica ?acaeoey ineiaeiaiee. Aeey ii?aaeaeaiey ?aiieo eciaiaiee ninoiyiey einoiie oeaie o 85 iaoeeaioia aue i?eiaiai iaoiae iaeiioioiiiie aani?aoeeiiao?ee a aeenoaeueiii yieoeca e a aeeaoeca eo/aaie einoe. O aieueiuo oaeaea eco/aeny ieia?aeueiue iaiai e iaiai i?aaie/aneeo eiiiiiaioia niaaeeieoaeueiie oeaie. Onoaiiaeaii, /oi o aieueoeinoaa (81,55%) iiae?inoeia n NANO e aaia?aeeciaaiiuie oi?iaie ?A eiaee ianoi ineiaeiaiey aetheiei?oeeieaeiie oa?aiee, i?e yoii o aieueoeinoaa iaoeeaioia ioia/aii ni/aoaiea ianeieueeeo ec ieo. Aoi?ia ianoi iinea eooeiaieaeiiai neiae?iia ii /anoioa ?acaeoey caieiaee ii?aaeaiey einoiie oeaie n o/aoii i?iaaaeaiiiai aeaineoiiao?e/aneiai enneaaeiaaiey e eeeie/aneeo i?iyaeaiee a aeaea aieaaiai neiae?iia a iaeanoe iicaiii/ieea, oneeeaathuaainy i?e aeeeoaeueiie noaoe/aneie iaa?ocea, aeeaaiinoe?iaaiiuo ?aioaaiieiae/anee eiii?anneiiiuo ia?aeiiia iicaiieia, anaioe/aneeo iae?icia aieiaee aaae?aiiie einoe. Onoaiiaeaii, /oi i?e NANO o aeaoae e iiae?inoeia nieaeaiea iieacaoaeae IIE i?enoonoaiaaei aieaa, /ai o iieiaeiu aieueiuo (56,34%), /oi cia/eoaeueii i?aauoaei eeeie/anee auyaeyaiua eciaiaiey (p<0,001). I?e yoii aeinoiaa?iia nieaeaiea aaniethoiuo iieacaoaeae IIE i?ienoiaeeei i?e anao iicieiae/aneeo oi?iao /aua a aeenoaeueiii yieoeca eo/aaie einoe (61,76%) ii n?aaiaieth n i?ieneiaeueiui (50,72%), o eeoe aeaineiai iiea. O 18,5% aieueiuo noaiaiue au?aaeaiiinoe inoaiiaiee aeinoeaaea e?eoa?eaa inoaiii?ica. *anoioa e au?aaeaiiinoue inoaiiaiee ia?anoaee n oaaee/aieai i?iaeieaeeoaeueiinoe caaieaaaiey e aeeeoaeueiinoe i?iaiaeeiie aetheiei?oeeieaeiie oa?aiee. Inoaiiaie/aneee neiae?ii ?acaeaaeny /aua i?e oyaeaeuo eeeie/aneeo aa?eaioao oa/aiey n aunieie noaiaiueth aeoeaiinoe iaoieiae/aneiai i?ioeanna, cia/eoaeueiuo i?aaiiuo ii?aaeaieyo, a oii /enea i?e ?acaeoee na?iceoia, ioeueiiieoa, iao?eoa e i?e aicieeiiaaiee au?aaeaiiuo o?ioe/aneeo ?anno?ienoa, nonoaaiiai e iuoa/iiai neiae?iiia, a oaeaea iiiaeanoaaiiii aiaea/aiee a i?ioeann nonoaaia i?e iieea?o?eoe/aneeo oi?iao ?aaiaoieaeiiai a?o?eoa. Iiauoaiea o?iaiae oinoaoaiee, oiiae?ieoeinoeueoaoia, noiia?iuo aeeeicaieiiaeeeainoeueoaoia, e?aaoeieia, yene?aoeee o?iiiauo eeneio e aeoeaiinoe eeneie oinoaoacu, a oaeaea nieaeaiea niaea?aeaiey eaeueoeey a e?iae aieueiuo NANO neoaeeee iaaeaaii?eyoiuie i?eciaeaie a ioiioaiee ?acaeoey inoaiiaiee. Iaia?oaeaiea ia yoii oiia aunieeo o?iaiae uaei/iie oinoaoacu e yene?aoeee ienei?ieeia iiaeao naeaeaoaeuenoaiaaoue i iaee/ee o oaeeo aieueiuo inoaiiaie/aneiai neiae?iia. ?ac?aaioai aunieieioi?iaoeaiue aeai?eoi i?iaiica ineiaeiaiee, a oii /enea inoaiiaiee, iicaieythuee i?iaiice?iaaoue aa?iyoiinoue aicieeiiaaiey iiai/iuo yooaeoia i?iaiaeeiie aetheiei?oeeieaeiie oa?aiee e naiaa?aiaiii aiineoue ei?aeoeau a eiiieaeniia ea/aiea aieueiuo NANO. Eeth/aaua neiaa: aeaoe, iiae?inoee, nenoaiiua aieacie niaaeeieoaeueiie oeaie, ieia?aeueiay ieioiinoue einoe, inoaiiaiey, iaiai, i?aaie/aneea eiiiiiaiou niaaeeieoaeueiie oeaie. SUMMARY Shevchenko N.S. Clinico-pathogenetic characteristic of osteopenic syndrome in systemic diseases of connective tissue in children and adolescents. - Manuscript. Competitive Thesis for the Degree of Candidate of Science (Medicine) in Speciality 14.01.10 - Pediatrics. Kharkiv State Medical University, Kharkiv, 1999. The work is aimed at studying the state of bone tissue in systemic diseases of connective tissue (SDCT) in children and adolescents by means of investigating bone mineral density (BMD) using the method of monophotonic absorptiometry and by determining the metabolism of connective tissue organic components and mineral metabolism, as well as establishing the place of osteopenia among the other complications in the course of corticosteroidal therapy. It has been found that in most patients (81,55%) there occur certain complications in the course of the treatment including bone tissue disorders. The BMD decrease has been observed in 56,34% of the patients which significantly exceeds clinically revealed changes (p<0,001) in all the nosologic forms observed more frequently in the distal region of the radius in female patients, rather than in the proximal region of the bone. The incidence rate and the level of osteopenia increase with the increase in the disease duration and glucocorticoids administration, in severe clinical cases, in cases of heavy organic lesions (especially renal lesions), and in multiple articular lesions due to rheumatoid arthritis (RA). It has been shown that osteopenia is very likely a pathogenetically caused disorder in SDCT and in RA in teen-agers. It has been established that increases in blood phosphorus levels as well as in the levels of chondroitinsulphates, creatinine, uronic acids excretion and in acidic phosphatase activity, as well as certain decrease in blood calcium concentration, are unfavorable sings of osteopenia development. The presence of high levels of alkaline phosphatase and of intensified oxyproline excretion testifies to osteopenic syndrome development. The elaborated highly informative algorithm for complications prognosis, including osteopenia, makes it possible to predict the probability of side effects of the therapy and to make timely corrections in the combined treatment of patients with SDCT. Key words: children, adolescents, systemic diseases of connective tissue, bone mineral density, osteopenia, metabolism, connective tissue organic components. NIENIE NEI?I*AIUe AO – a?oa??aeueiee oene AI – aoceeeiaee ia??a?oa???o AAAn – ae?eicai?iiae?eainoeueoaoe AE – aetheiei?oeei?aee NONO – nenoaii? oai?iae niieo/ii? oeaieie AeI – aea?iaoii?iceo CN? – cao?eiea noaoaaiai ?icaeoeo CO? – cao?eiea oaii?a ?inoo IO – iaino?oaeueia ooieoe?y IUE – i?ia?aeueia u?euei?noue e?noee II – inoaiiai?y ?A – ?aaiaoi?aeiee a?o?eo ?C – ?aaiaoe/i? caoai?thaaiiy NAe – neea?iaea?i?y N*A – nenoaiiee /a?aiiee aia/ae ON – oiiae?i?oeinoeueoaoe

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