I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO

?I. AEAAeAI?EA I.I.AIAIIIEUeOess

AEEAAAeEI Aieaneaa Aieaneaaiae/

OAeE 618.1:615.256.5:616.24-002.5

EE?I?EI-EAAI?AOI?IA IAA?OIOOAAIIss I?AeAI?O

IIOEIAEUeIEO IAOIAe?A EIIO?AOeAIOe?? AeEss AE?IIE

C OOAA?EOEUeICII EAAAIUe

14.01.01 — Aeooa?noai oa a?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao?

?i.aeaae. I.I. Aiaiiieueoey IIC Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? A?oaiiiia Aieiaeeie? Na?a?ei-

ae/, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.I.I.Aiaiiieueoey (i.Ee?a),

caa?aeoaa/ eaoaae?ith aeooa?noaa oa a?iaeieia?? N2.

Io?oe?ei? iiiiaioe:

*eai-ei?aniiiaeaio AII ? IAI Oe?a?ie, aeieoi? iaaee/ieo iaoe,

i?ioani? Noaiaie?anueea Aaeeia Einoyioei?aia, Iaoe?iiaeueiee iaaee/-

iee oi?aa?neoao ?i. I.I.Aiaiiieueoey, i?ioani? eaoaae?e aeooa?noaa

oa a?iaeieia?? N1.

Aeieoi? iaaee/ieo iaoe, i?ioani? Nieuenueeee sse?a Ii?oe??eiae/,

?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, caa?-

aeoaa/ a?aeae?eaiiyi a?iaeieia??.

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?

ina?oe ?i. I.E. Ooi?ea, IIC Oe?a?ie, eaoaae?a aeooa?noaa ? a?iaei-

eia??N1.

Caoeno a?aeaoaeaoueny «01» ea?oiy 1999 ?. i ____ aiae. ia

can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.003.03 i?e Iaoe?iiaeue-

iiio iaaee/iiio oi?aa?neoao? ?i.aeaae. I.I.Aiaiiieueoey (252004,i.Ee-

?a 4, aoeueaa? Oaa/aiea, 13)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? IIO (252057,

i.Ee?a 57, Ciieia?/ia,1)

Aaoi?aoa?ao ?ic?neaiee «28» ethoiai1998 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee A?oianueeee ss.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue i?iaeaie. Ca inoaiii ?iee a Oe?a?i? iaaieiii

iia??oo?oueny ai?aeai?ieia?/ia neooaoe?y c ooaa?eoeueicii. ?iciianthae-

aeai?noue ooaa?eoeueico, ye ? nia?oi?noue, iei ni?e/eiaia, ca?eueoo-

thoueny. sseui o 1993 ?. caoai?thaai?noue ia ooaa?eoeueic a Oe?a?i?

noaiiaeea 38,0 ia 100 oen. /ieia?e, oi o 1995 ?. oeae iieaciee

ae??n aei 42,0 ia 100 oen. /ieia?e, a?aeiia?aeii nia?oi?noue a 1993

?. aoea 10,5 ia 100 oen. /ieia?e, a o 1995 ?. aiia ca?eueoeeanue aei

14,1 ia 100 oen. /ieia?e (A.I.Iaeueiee ? ?io?, 1997; TH.?.Oauaiei,

1995). Ca?ac a Oe?a?i? ooaa?eoeueic ui??/ii caae?a? aeeooy o 7 —

7,5 oen. ethaeae, ui iaaaaaoi a?eueoa, i?ae an? ?io? ?ioaeoe?ei? oai-

?iae ?acii acyo? (TH.?.Oauaiei, 1996).

Iniaeeao i?iaeaio noaiiaeoue aaa?oi?noue ? iieiae o ae?iie c

ooaa?eoeueicii eaaaiue, yeei, ye i?aaeei, aiie i?ioeiieacai?

(TH.A.O?oa?, 1994).

I?e ii?aeiaii? ooaa?eoeueico eaaaiue ? aaa?oiino? inoaiiy iiaea

nooo?ai iia??oeoe ia?aa?a iniiaiiai caoai?thaaiiy. Caaino?aiiy

niaoeeo?/iiai i?ioeano iae/ano?oa aeieea? a ia?o? i?nyoe? aaa?oiin-

o?, a oaeiae a i?neyiieiaiaiio ia??iae?. A?aei?/aii, ui ia?a?eaaiiy

aaa?oiino? o ae?iie, oai?eo ia ooaa?eoeueic eaaaiue, oaeiae ia

iie?ioo? noaio oai?i?, a ?ieiee caaino?th? niaoeeo?/iee i?ioean a

eaaaiyo. A naith /a?ao ooaa?eoeueiciee i?ioean a eaaaiyo iaaaoeaii

ae?? ia ia?aa?a aaa?oiino? ? iieia?a, a oaeiae noai ieiaeo (E.N.Ia?-

n?ai?iia, 1974; O.A.*aaioa?ueiaa, 1990).

Oaeei /eiii, ae?ieai, ye? oai??thoue ??ciiiai?oieie oi?iaie oo-

aa?eoeueico eaaaiue, aaa?oi?noue /ano?oa ca ana i?ioeiieacaia ? ia-

?aae ieie iinoa? i?iaeaia caiia?aaiiy aeieeiaiiy aaa?oiino?. Ia

nueiaiaei?oi?e aeaiue ?nio? aaeeea e?euee?noue aeine?aeaeaiue,
i?enay/aieo

ieoaiiyi ai?iiiaeueii? eiio?aoeaioe?? o caei?iaeo ae?iie (A.I.Aaioe-

eianueeee, 1997; ?.A.Aiae, 1996; 1997; ?.A.Iaio?eiaa oa ?i., 1995;

L.Escobeno et al., 1988, M.Gayr et al., 1990). A oie aea /an

i?aoeue, i?enay/aieo aeai?o i?ioecaie?aeieo cania?a o ae?iie c ??cii-

iai?oieie iicieia?/ieie oi?iaie caoai?thaaiiue, iaaaaaoi

(O.O.Oaec??aa oa ?i., 1991; R.H.Mattson et al., 1986), a aeine?ae-

aeaiue, i?enay/aieo ieoaiith eiio?aoeaioe?? o oai?eo ia ooaa?eoeueic

eaaaiue, a aeinooii?e iai e?oa?aoo?? ie ia ciaeoee. ?iaioa aeeiiaia

a ?aieao iaoe?iiaeueii? i?ia?aie «Ieaioaaiiy n?i’?» a?aeiia?aeii Iin-

oaiiae Eaa?iaoo I?i?no??a Oe?a?ie a?ae 13 aa?aniy 1995 ?. oa eiii-

eaenii? IAe? eaoaae?e aeooa?noaa ? a?iaeieia?? N2 IIO «?ic?iaea ii-

aeo iaoiae?a ?aiiuei? ae?aaiinoeee ? e?eoaaiiy aai?oaeueiiai ooaa?eo-

eueico o ae?iie c iaoith i?iaiicoaaiiy ? ?aaa?e?oaoe?? ?ai?iaeoeoeaii?

ooieoe??», N aea?ae?a?no?aoe?? 01940208821.

Iaoa ?iaioe. Ia i?aenoaa? ee?i?/ieo aeine?aeaeaiue iaoeiai ia-

a?oiooaaoe canoinoaaiiy i?aeueieo eiio?aoeaioea?a c i?i?iaeueiith

e?euee?noth iia?/ieo oneeaaeiaiue aeey ae?iie, ye? oai??thoue
??ciiiai?o-

ieie oi?iaie ooaa?eoeueico eaaaiue.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1. Aea/eoe iniiai? iieacieee ooieoe?? ia/?iee, cai?oath/i?

nenoaie e?ia?, ai?iiiaeueiiai noaoono ? ia oe?e iniia? aea?aoe

iaea?eueo i?eeiyoi? i?aeuei? eiio?aoeaioeae aeey ae?iie, ye? oai??thoue

??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue.

2. Ia i?aenoaa? ee?i?ei-noaoenoe/iiai aiae?co ? noaio aiaeie-

?eiii? ooieoe?? y?/iee?a aea/eoe aoaeoeai?noue ? ioe?ieoe /anoioo ?

no?oeoo?o oneeaaeiaiue i?ae /an canoinoaaiiy ??cieo i?aeueieo eiio?a-

oeaioea?a.

3. Aea/eoe ai?no caaaeueiiai a?eeo, aeueaoi?io, oieanoa?eio,

a?e??oa?io caaaeueiiai ? iai?yiiai, o?a?eiiaaio, eiioeaio?aoe?th i?i-

aanoa?iio ? ano?aae?ieo a ieaci? e?ia? i?e o?eaaeiio canoinoaaii?

i?aeueieo eiio?aoeaioea?a ae?ieaie, ye? oai??thoue ia ooaa?eoeueic ea-

aaiue.

4. Aea/eoe noai aiaeie?eiii? ooieoe?? y?/iee?a o ae?iie c

??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue i?ney a?aei?ie i?aeueieo

eiio?aoeaioea?a.

5. Ia i?aenoaa? io?eiaieo ?acoeueoao?a aeine?aeaeaiiy ?ic?iaeoe

?aeiiaiaeaoe?? ii canoinoaaiith iaea?eueo aoaeoeaieo ? aacia/ieo

i?aeueieo eiio?aoeaioea?a ae?ieaie, ye? oai??thoue ??ciiiai?oieie oi?-

iaie ooaa?eoeueico eaaaiue.

Iaoeiaa iiaecia ?iaioe. Aia?oa i?iaaaeaia ee?i?/ia ai?iaaoe?y

??cieo i?aeueieo eiio?aoeaioea?a o ae?iie, ye? oai??thoue ia ooaa?-

eoeueic eaaaiue. I?e ee?i?/iiio canoinoaaii? ia?aeiio, ?eaaa?aeiio ?

eiio?io?io ae?ieaie, ye? oai??thoue ia ooaa?eoeueic eaaaiue, aia?oa

anoaiiaeaii, ui ia?aeii i?e eiai aenie?e eiio?aoeaioeai?e aoaeoea-

ino? aea? iaeiaioo e?euee?noue iia?/ieo oneeaaeiaiue. Aia?oa i?iaaaea-

ii eiiieaenia aea/aiiy iniiaieo iieaciee?a ooieoe?? ia/?iee, cai?-

oath/i? nenoaie e?ia?, aiaeie?eiii? ooieoe?? y?/iee?a o ae?iie,

oai??th/eo ??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue, ia?aae ? i?ae

/an o?eaaeiai canoinoaaiiy i?aeueiiai eiio?aoeaioeao ia?aeii. Anoa-

iiaeaii, ui eiioeaio?aoe?y o?a?eiiaaio, ye a e?ia? oai?eo ia ooaa?-

eoeueic eaaaiue, oae ? o caei?iaeo ae?iie, ca?eueoo?oueny ia o?aoueiio

i?nyoe? i?eeiio ia?aeiio, aea ia ia?aaeuo? aa?oi?o iaae ii?ie. Iiea-

caia aeniea eiio?aoeaioeaia aoaeoeai?noue ia?aeiio (100%) i?e o?eaa-

eiio eiai canoinoaaii? ae?ieaie, oai??th/eie ??ciiiai?oieie oi?ia-

ie ooaa?eoeueico eaaaiue. Anoaiiaeaii, ui ia o?aoueiio i?nyoe? i?ney

a?aei?ie ia?aeiio o ae?iie, oai?eo ia ooaa?eoeueic eaaaiue, aiaeie?ei-

ia ooieoe?y y?/iee?a iiai?noth a?aeiiaeth?oueny. Aia?oa ?ic?iaeai? ?a-

eiiaiaeaoe?? ii canoinoaaiith i?aeueiiai eiio?aoeaioeao ia?aeii ae?iea-

ie, ye? oai??thoue ??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue.

I?aeoe/ia cia/aiiy ?iaioe. I?iaaaeai? iaie aeine?aeaeaiiy aeicai-

eeee ?c ?icia?ooy ?nioth/eo i?aeueieo eiio?aoeaioea?a ia?aoe

iaea?eueo aoaeoeaiee eiio?aoeaioeaiee i?aia?ao aeey ae?iie c ??cieie

oi?iaie ooaa?eoeueico eaaaiue. Anoaiiaeaii, ui i?aeueiee eiio?aoeai-

oea ia?aeii, yeee i?noeoue 0,05 ia aoei?eano?aae?ieo ? 0,25 ia eaai-

ii?aano?aeo ? iaea?eueo aacia/iei oa aoaeoeaiei i?aia?aoii, yeee

iio??aii ?aeiiaiaeoaaoe ae?ieai, ye? oai??thoue ia ooaa?eoeueic ea-

aaiue. I?e canoinoaaii? ia?aeiio ae?ieaie c ooaa?eoeueicii eaaaiue a

ia?o? o?e i?nyoe? iio??aai ?aoaeueiee ee?i?/iee iaaeyae ? eiio?ieue

eiaaoeia?aie e?ia?.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii o?noue

iaoeiaeo ?ia?o, a oiio /ene? /ioe?e iaoeia? noaoo? a iaoeiaeo

aeo?iaeao oa aea? a iaoa??aeao iaoeiaeo eiioa?aioe?e.

Ai?iaaoe?y ?iaioe. Iniiai? iieiaeaiiy aeena?oaoe?? aeiiia?aeaeenue

? iaaiai?thaaeenue ia iaoeia?e ?aaeyinueei-ao?oiae?enuee?e iaaee/i?e

eiioa?aioe?? (?anioae?ea Ao?oiae?, Aoaeoiao?a, 1989), ia i?nueeiio

oiaa?enoa? aeooa??a-a?iaeieia?a i. Ee?aa o 1992 ?.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ?in?enue-

eith iiaith ia 136 noi?. iaoeiiieno. Neeaaea?oueny ?c anooio, iaeyaeo

e?oa?aoo?e, ?icae?eo i?i iaoa??aee ? iaoiaee aeine?aeaeaiiy, i’yoe

?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo

?aeiiaiaeaoe?e oa nieneo e?oa?aoo?ieo aeaea?ae, aei yeiai aoiaeeoue 130

?ia?o a?o/eciyieo aaoi??a ? 115 — ca?oa?aeieo. Aeena?oaoe?y i?i?ethn-

o?iaaia 9 oaaeeoeyie oa 8 iaethieaie.

Aeaeea?aoe?y eiie?aoiiai iaoeiaiai aianeo a ?ic?iaeo iaoeiaeo

?acoeueoao?a, ye? aenoaathoueny ia caoeno. Aeena?oaioii iniaenoi i?i-

aaaeai? iaoaioiee iiooe, aiae?c e?oa?aoo?e, ee?i?/ia ? ee?i?ei-ea-

ai?aoi?ia ianoaaeaiiy oai?eo ia ooaa?eoeueic eaaaiue, ye? i?eeiaee

??ciiiai?oi? i?aeuei? eiio?aoeaioeae. Aaoi?ii naiino?eii i?iaaaeaii

aiae?c noaoenoe/ii? ia?iaee iaoa??ae?a aeena?oaoe??. Ee?i?/i? aein-

e?aeaeaiiy cae?enithaaeenue ia aac? i?nueeiai i?ioeooaa?eoeueiciiai
aeen-

iaina?o ? i?ioeooaa?eoeueiciiai aeeniaina?o N6, ia ee?i?/i?e aac?

eaoaae?e aeooa?noaa oa a?iaeieia?? N2 Iaoe?iiaeueiiai iaaee/iiai

oi?aa?neoaoo ?i. aeaae. I.I.Aiaiiieueoey a Oeaio?aeuei?e i?nuee?e

ee?i?/i?e e?ea?i? i. Ee?aa.

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. O ia??iae c 1987 ii 1997 ?. a

i?nueeiio i?ioeooaa?eoeueiciiio aeeniaina?? ? i?ioeooaa?eoeueiciiio

aeeniaina?? N6 iaie ianoaaeaii 172 ae?iee c ??cieie oi?iaie ooaa?eo-

eueico eaaaiue. O?eaae?noue caoai?thaaiiy noaiiaeea a?ae 2 aei 4 ?ie?a.

C aeiiiiiaith oano?a ooieoe?iiaeueii? ae?aaiinoeee (aacaeueia oai-

ia?aoo?a, «oaiiiai c?ieoe?») o 150 ae?iie aeyaeaii aeaiooaciee iain-

o?oaeueiee oeeee. O 22 ae?iie aoa iaeiioaciee iaino?oaeueiee oeeee ? ?o

ie ia aeeth/eee a iaoa aeine?aeaeaiiy. Oaeei /eiii, iniiaio a?oio

neeaee 150 ae?iie, ?c ieo 83 (55,3%) oai??ee ?io?eueo?aoeaiith oi?-

iith ooaa?eoeueico eaaaiue. Ooaa?eoeueiciee i?ioean a oac? ?io?eueo?a-

oe?? aoa o 40 ae?iie, na?aae ieo o 4 a iie?io? aeyaeai? i?eiaaeoa???

ooaa?eoeueico (AE+). Ooaa?eoeueic a oac? ?iciaaeo aoa o 19 ae?iie,

na?aae ieo o 17 a iie?io? aeyaeai? i?eiaaeoa??? ooaa?eoeueico (AE+).

O 14 ae?iie c ?io?eueo?aoeaiith oi?iith ooaa?eoeueico eaaaiue i?i-

oean ciaoiaeeany a oac? in?iai?iiy, i?e oeueiio o 13 ae?iie a iie?io?

aoei aeyaeai? i?eiaaeoa???oo aa?eoeueico (AE+). Oaca ?icniieooaai-

iy aoea o 10 ae?iie, i?eiaaeoa??e ooaa?eoeueico a iie?io? i? iaei???

c oeeo ae?iie ia aoei aeyaeaii. Anueiai o 34 ae?iie c ?io?eueo?aoeaiith

oi?iith ooaa?eoeueico eaaaiue a iie?io? aoee aeyaeai? i?eiaaeoa???

Eioa (AE+).

Aiaieuaaei ooaa?eoeueicii eaaaiue oai??ee 48 (32%) ae?iie. ?c

ieo o 35 ae?iie i?ioean ciaoiaeeany o oac? ?io?eueo?aoe??, o 5 ae?iie a

iie?io? ciaeaeaii i?eiaaeoa???oo aa?eoeueico (AE+); 6 ae?iie oai??ee

oe??th oi?iith ooaa?eoeueico eaaaiue o oac? ?iciaaeo, i?e oeueiio
na?aae

ieo o 5 a iie?io? ciaeaeaii i?eiaaeoa???oo aa?eoeueico (AE+). O oa-

c? ?icniieooaaiiy i?ioean ciaoiaeeany o 7 ae?iie, — i? a iaei??? c

ieo a iie?io? ia aoei ciaeaeaii i?eiaaeoa??e ooaa?eoeueico.

I?e aeine?aeaeaii? iie?ioe a a?oi? ae?iie, oai??th/eo aiaieuaaith

oi?iith ooaa?eoeueico eaaaiue, o 10 ae?iie aoei ciaeaeaii a iie?io?

i?eiaaeoa???oo aa?eoeueico (AE+).

A?oia oai?eo ia aeenai?iiaaiee ooaa?eoeueic eaaaiue neeaaeaea 19

(12,66%) ae?iie. ?c ieo 11 ae?iie oai??ee oe??th oi?iith ooaa?eoeueico

a oac? ?io?eueo?aoe??? o 3 a iie?io? aoee ciaeaeai? i?eiaaeoa???

ooaa?eoeueico (AE+). I?ioean o oac? ?iciaaeo ciaoiaeeany o 2 ae?iie, a

iie?io? eiaeii? c ieo aoei ciaeaeaii i?eiaaeoa??? ooaa?eoeueico

(AE+). Oe??th oi?iith a oac? ?icniieooaaiiy oai??ee 5 ae?iie, o

iaei??? c ieo a iie?io? aoee aeyaeai? i?eiaaeoa??? ooaa?eoeueico

(AE+). O iaei??? ae?iee i?ioean ciaoiaeeany o oac? ou?eueiaiiy, i?ei-

aaeoa??e ooaa?eoeueico a iie?io? ia ciaeaeaii. Anueiai na?aae ae?iie,

ye? oai??thoue aeenai?iiaaiith oi?iith ooaa?eoeueico eaaaiue, o 6 a iie-

?io? aoei ciaeaeaii i?eiaaeoa???oo aa?eoeueico (AE+).

An? ianoaaeai? ae?iee, ye? oai??thoue ia ooaa?eoeueic eaaaiue,

i?eeiaee oae? i?ioeooaa?eoeueici? i?aia?aoe o aeicao: no?aioii?-

oeei — 15 ia/ea, ?cii?ac?ae — 5 ia/ea, aoaiaooie — 20 ia/ea, ??oai-

i?oeei — 10 ia/ea. O?eaae?noue e?eoaaiiy aeuacaaaeaieo oi?i ooaa?eo-

eueico eaaaiue aoea a na?aaeiueiio a?ae aeaa’yoe aei aeaaiaaeoeyoe
i?nyoe?a.

Aeey aeeiiaiiy iinoaaeaieo caaaeaiue iaie aoee i?ecia/ai? ae?i-

eai c ooaa?eoeueicii eaaaiue i?aeuei? eiio?aoeaioeae c iaeei ai?noii

ae?th/eo ?a/iaei. Oea eiia?iiaai? iiiioaci? i?aia?aoe: ia?aeii — a

iaei?e oaaeaooe? i?noeoueny 0,25 ia eaaiii?aano?aeo ? 0,05 ia

aoei?eano?aae?ieo, ?eaaa?aeii — a iaei?e oaaeaooe? i?noeoueny 0,15 ia

eaaiii?aano?aeo ? 0,03 ia aoei?eano?aae?ieo, a oaeiae eiio?io?i,

iaeia oaaeaoea yeiai i?noeoue 0,5 ia ae?aoeaoaoo ao?iiae?ieo. Oe? i?a-

ia?aoe iathoue aenieo eiio?aoeaioeaio aoaeoeai?noue ? aea?aeii

a?ae??ciythoueny iaaaeeeith e?euee?noth iia?/ieo oneeaaeiaiue i?e ?o
can-

oinoaaii? caei?iaeie ae?ieaie. Aeoiaey/e c oeueiai, ie ae??oeee canoi-

noaaoe oe? i?aia?aoe c eiio?aoeaioeaiith iaoith o ae?iie, ye? oai??thoue

??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue.

An?o ianoaaeaieo oai?eo ae?iie, o yeeo ia aoei i?ioeiieacaiue

aeey canoinoaaiiy i?aeueieo eiio?aoeaioea?a, ie ?icae?eeee ia o?e

a?oie ii 50 a eiaei?e. A ? a?oi? ae?iee i?eeiaee ia?aeii, a ?? — ?e-

aaa?aeii, a a ??? — eiio?io?i. *aoaa?oa a?oia (eiio?ieueia) i?noeea

50 caei?iaeo ae?iie. A?oie ae?iie, oai??th/eo ia ooaa?eoeueic eaaaiue ?

canoiniaoth/eo ??ciiiai?oi? i?aeuei? eiio?aoeaioeae (ia?aeii, ?e-

aaa?aeii, eiio?io?i), aoee iaeii??aei? ca oi?iith caoai?thaaiiy ooaa?-

eoeueicii (oaae.1).

Ia?aeii ? ?eaaa?aeii aaeeaaee ii iaei?e oaaeaooe? a aeaiue i?ioyaii

o?ueio oeaei?a (c 5 ii 26 aeaiue iaino?oaeueiiai oeeeeo) c ianooiiei

oeaeiaaei ?ioa?aaeii. Eiio?io?i oaeiae i?eeiaee ii iaei?e oaaeaooe? a

aeaiue eiaeiiai aa/i?a c ia?oiai aeiy iaino?oaeueiiai oeeeeo aac ia?a?-

ae, aac ?ioa?aae?a (a iino?eiiio ?aaeei?).

An? ianoaaeai? ae?iee aaeeaaee eiio?aoeaioeae i?ioyaii aeaaiaaeoey-

oe i?nyoe?a ? ciaoiaeeeenue i?ae iino?eiei ee?i?/iei iaaeyaeii.

A aeeiai?oe? aaeeaaiiy i?aeueieo eiio?aoeaioea?a o an?o /ioe?ueio

a?oiao ie niinoa??aaee ca e?euee?noth aeieeath/eo iia?/ieo oneeaae-

iaiue, a oaeiae i?ae?aoiaoaaee e?euee?noue iaaaaeaieo aaa?oiinoae. E??i

oiai, /anoioo aaa?oiino? oaeiae i?ae?aoiaoaaee ia noi ae?iie (o a?ae-

nioeao).

Oaaeeoey 1.

?iciiae?e oai?eo ia ooaa?eoeueic eaaaiue ae?iie, aaeeaath/eo
eiioeao?aioeae, ca oi?iaie caoai?thaaiiy

Oi?ie ooaa?eoeueico eaaaiue

I?aeuei? ?io?eueo?aoeaiee Aiaieuaaee Aeenai?iiaaiee Anueiai

eii?aoeaioeae ooaa?eoeueic ooaa?eoeueic ooaa?eoeueic

aan. % aan. % aan. % aan. %

Ia?aeii 26 52.0 16 32.0 8 16.0 50
100

?eaaa?aeii 29 58.0 15 30.0 6 12.0
50 100

Eiioeio?i 28 56.0 17 34.0 5 10.0
50 100

C iaoith aea/aiiy aieeao i?aeueiiai eiio?aoeaioeao ia?aeiia ia

iniiai? iieacieee ia/?iee, cai?oath/i? nenoaie e?ia? ? ai?iiiaeue-

iiai noaoono ae?iie, oai??th/eo ??ciiiai?oieie oi?iaie ooaa?eoeueico

eaaaiue, i?e o?eaaeiio canoinoaaii? i?aia?aoo iaie aea/aia ci?ia

ai?noo caaaeueiiai a?eeo, aeueaoi?io, caaaeueiiai a?e??oa?io, iai?y-

iiai a?e??oa?io, oieanoa?eio ? o?a?eiiaaio e?ia?, a oaeiae ai?noo

17-(-ano?aae?ieo ? i?iaanoa?iio ieacie e?ia?.

Aecia/aiiy oieanoa?eio ie i?iaiaeeee oa?iaioaoeaiei eiei?eia-

o?e/iei iaoiaeii ia aia?ao? «SBA-300» o??ie CIBA-CORNING.

Aecia/aiiy caaaeueiiai ? iai?yiiai a?e??oa?io i?iaiaeeeinue ia-

oiaeii ??iae?aoaea ia aia?ao? «SBA-300» o??ie CIBA-CORNING.

Caaaeueiee a?eie aecia/aee a?o?aoiaei iaoiaeii.

Aeueaoi?i aecia/aee eiei?eiao?e/iei iaoiaeii c a?iie?acieii

caeaiei ii Bartholomeu and Doumas.

O?a?eiiaai aecia/aee ca iaoiaeii ?ooaa?aa.

Aea/aiiy oeeo iieaciee?a i?iaiaeeeinue a aeeiai?oe? i?eeiio eiio-

?aoeaioeao c ?ioa?aaeii a o?e i?nyoe?. Aeey aea/aiiy ooieoe?iiaeueiiai

noaio y?/iee?a ae?iie, oai??th/eo ia ooaa?eoeueic eaaaiue, ie aecia-

/aee ai?no 17- (-ano?aae?ieo ? i?iaanoa?iio ieacie e?ia? ia?aae aaee-

aaiiyi i?aeueiiai eiio?aoeaioeao (eiio?ieueiee oeeee).

Aeey aea/aiiy aieeao ia?aeiio ia aiaeie?eiio ooieoe?th y?/iee?a

ae?iie, oai??th/eo ia ooaa?eoeueic eaaaiue, iaie i?iaiaeeeinue aecia-

/aiiy oeeo ai?iii?a a ?, ???, YI iaino?oaeueiiio oeeeeao ia oii?

aaeeaaiiy i?aia?aoo.

Aeey eiio?ieth ca a?aeiiaeaiiyi ooieoe?? y?/iee?a i?ney a?aei?ie

ia?aeiio ie /a?ac o?e i?nyoe? i?iaaee aecia/aiiy 17-( -ano?aae?ieo ?

i?iaanoa?iio ieacie e?ia? o ae?iie c ooaa?eoeueicii eaaaiue. Aein-

e?aeaeaiiy i?iaiaeeeinue /ioe?e ?ace i?ae /an iaino?oaeueiiai oeeeeo,

eiaeiiai oeaeiy o o?eniaaiee aeaiue, ui aoei c?o/ii aeey ae?iie, ye?

i?eeiaee o/anoue o o?eaaeiio ianoaaeaii? (5, 12, 19 ? 26 aeaiue iain-

o?oaeueiiai oeeeeo).

Ai?no ??aith 17-(-ano?aae?ieo ? i?iaanoa?iio a ieaci? e?ia?

aecia/aany ?aae?i?ioiieia?/iei iaoiaeii c aeei?enoaiiyi noaiaea?oieo

iaai??a KIT o??ie «Cea-Ire-Sorin».

?acoeueoaoe aeine?aeaeaiue noaoenoe/ii ia?iaeyeenue c aeei?enoai-

iyi caaaeueiii?eeiyoeo iaoiaeee ? e?eoa???a No’thaeaioa.

?acoeueoaoe aeine?aeaeaiue ? ?o iaaiai?aiiy. I?e aea/aii? ee?i?/-

ieo aeaieo, io?eiaieo i?ae /an o?eaaeiai aaeeaaiiy i?aeueieo eiio?a-

oeaioea?a ae?ieaie, oai??th/eie ia ooaa?eoeueic eaaaiue, a?aei?/aii, ui

ioaeioa, aethaioa, iaa?yeaiiy iiei/ieo caeic, aieiaiee a?eue, caia-

ii?i/aiiy, aeai?an?y niinoa??aaeenue a ia?o? i?nyoe? aaeeaaiiy i?aeue-

ieo eiio?aoeaioea?a, aea aiie cieeaee aei e?ioey o?aoueiai i?nyoey

aaeeaaiiy. Iaea?eueo iaaaaeaieie ? na?eicieie c on?o oneeaaeiaiue, ae-

ieeath/eo i?ae /an canoinoaaiiy i?aeueieo eiio?aoeaioea?a, aoee

i?aeiaino?oaeuei? e?iaioa/? oa aiaii?ay. I?e aea/aii? oeeo iaaaaea-

ieo aoaeo?a iaie anoiiaeaii, ui iaea?eueoa ?o /anoioa a?aei?/aia o

ae?iie, aaeeaaaoeo eiio?io?i. Na?aae ae?iie, aaeeaaaoeo ia?aeii,

a?aei?/aia iaeiaioa e?euee?noue i?aeiaino?oaeueieo e?iaioa/ ? ia aoei

aeiaaee?a aiaii?a?. I?aeiaino?oaeuei? e?iaioa/? niinoa??aaeenue, a

iniiaiiio, a ia?o? oeeeee aaeeaaiiy ? a iiaeaeueoiio cieeaee naiin-

o?eii aac e?eoaaiiy.

I?e aea/aii? eiio?aoeaioeaii? aoaeoeaiino? ia?aieo iaie i?a-

ia?ao?a anoaiiaeaii, ui ia?aeii ? iaea?eueo aoaeoeaiei i?ioecai-

e?aeiei caniaii. Oae, na?aae ae?iie, aaeeaaaoeo ia?aeii, iaie ia

a?aei?/aii aeiaeiiai aeiaaeeo aaa?oiino? (100% aoaeoeai?noue). A a?oi?

ae?iie, aaeeaaaoeo ?eaaa?aeii, caaaa?oi?ea iaeia ae?iea (98% aoae-

oeai?noue). Na?aae aaeeaaaoeo eiio?io?i caaaa?oi?ee aea? ae?iee (96%

aoaeoeai?noue). Aeai? niinoa?aaeaiue iaaaaeai? a oaaeeoe? 2.

Oaeei /eiii, i?iaaaeaia ee?i?/ia ai?iaaoe?y ia?aieo iaie i?a-

ia?ao?a (ia?aeii, ?eaaa?aeii, eiio?io?i) na?ae/eoue, ui iaea?eueo

aoaeoeaiei eiio?aoeaioeaiei i?aia?aoii aeey ae?iie, oai??th/eo ??cii-

iai?oieie oi?iaie ooaa?eoeueico eaaaiue, ? ia?aeii. C iaoith aea/aiiy

aieeao ia?aeiio ia a?eeiaiooai?thth/o, i?aiaioio ooieoe?th ia/?iee ?

cai?oath/o nenoaio e?ia? i?e o?eaaeiio eiai canoinoaaii? ae?ieaie,

ye? oai??thoue ia ooaa?eoeueic eaaaiue, iaie a e?ia? ae?iie oe??? a?oie

aea/ai? oae? a?io?i?/i? iieacieee: ai?no caaaeueiiai a?eeo, aeueao-

i?io, o?a?eiiaaio, caaaeueiiai oa iai?yiiai a?e??oa?io, a oaeiae

oieanoa?eio. Oe? aeine?aeaeaiiy i?iaiaeeeenue ia?aae aaeeaaiiyi
i?aeueiiai

eiio?aoeaioeao (eiio?ieueiee oeeee). I?ae /an aaeeaaiiy ia?aeiio aeaca-

i? iieacieee aecia/aeenue ia i?ioyc? o?aoueiai, oinoiai, aeaa’yoiai

oa aeaaiaaeoeyoiai oeeee?a aaeeaaiiy i?aia?aoo. A eiio?ieuei?e a?oi?

caei?iaeo ae?iie, aaeeaaaoeo ia?aeii, ie oaeiae i?iaaee aiaeia?/i? a?-

io?i?/i? aeine?aeaeaiiy. Io?eiai? ?acoeueoaoe aeine?aeaeaiue iaaaaeai?
a

oaaeeoeyo 3 oa 4.

sse aeaeii c io?eiaieo aeaieo, a e?ia? caei?iaeo ae?iie ? o oai-

?eo ia ooaa?eoeueic eaaaiue ae?iie, canoiniaoth/eo ia?aeii, cia/ii?

??cieoe? a iieacieeao caaaeueiiai a?eeo, aeueaoi?io, oieanoa?eio,

caaaeueiiai ? iai?yiiai a?e??oa?io iaie ia cao?eniaaii. Oea na?ae-

/eoue i?i oa, ui aeaiee i?aia?ao ia aeeeeea? iaaaaeaiiai aieeao ia

a?eeiaiooai?thth/o ? i?aiaioio ooieoe?th ia/?iee.

A oie aea /an ai?no o?a?eiiaaio a e?ia? caei?iaeo ae?iie, can-

oiniaoth/eo ia?aeii, aeinoia??ii i?aeaeuoaaany ia o?aoueiio i?nyoe?

aaeeaaiiy i?aia?aoo, aea ia ia?aaeuoaaa aa?oi?o a?aieoeue ii?ie.

Ai?no o?a?eiiaaio a e?ia? ae?iie, oai??th/eo ooaa?eoeueicii eaaaiue,

canoiniaoth/eo ia?aeii, oaeiae i?aeaeuoaaany ia o?aoueiio i?nyoe? aaee-

aaiiy i?aia?aoo. I?aeaeuaiiy o?a?eiiaaio a e?ia? ae?iie, aaeeaath/eo

ia?aeii, i/aaeaeii, ca’ycaii c aeoeaaoe??th cai?oath/i? nenoaie e?ia?,

yea iiaea i?iyaeoenue o aeaeyae? o?iiaiaiaie?/ieo caoai?thaaiue o aeay-

eeo oai?eo, ye? aaeeaathoue i?aeuei? eiio?aoeaioeae.

Ae?oaa i?aeaeuaiiy ??aiy o?a?eiiaaio a e?ia? oai?eo ia ooaa?-

___________________________________________________________________

Oaaeeoey 2

*anoioa iia?/ieo oneeaaeiaiue, ye? aeieeathoue i?e
canoinoaaii?

i?aeueieo eiio?aoeaioea?a ae?ieaie, oai?eie ia
ooaa?eoeueic eaaaiue

Oaaeeoey 3

Aeeiai?ea ci?i a?io?i?/ieo iieaciee?a o caei?iaeo ae?iie eiio?ieueii?
a?oie ia oii? canoinoaaiiy ia?aeiio

Iacaa iieacieea Aei aaeea.

I?aeueiia

eiio?aoeai-oeao

Oa?i?i aaeeaaiiy i?aeueiiai eiio?aoeaioeao

3 i?nyoe? 6 i?nyoe?a 9 i?nyoe?a 12 i?nyoe?a

Oieanoa?ei

iiieue/e 3,85(0,13 4,43(0612* 4,14(0,12 4,01(0,11 3,90(0,10

Caaaeueiee a?eie a/ e 72,50(06 74,64(0,84 74,04(0,72* 74,84(0,83*
76,34(0,73*

Aeueaoi?ie % 56,21(0,93 56,61(0,82 55,87(0,79 54,98(0,79 53,69(0,82*

Caaaeueiee a?e??oa?i

ieiieue/ e 9,20(0,56 9,04(0,55 9,25(0,56 8,36(0,56 6,95(0,50*

Iai?yiee a?e??oa?i ieiieue/ e 2,63(0,16 2,54(0,15 2,74(0,15 2,56(0,15
2,58(0,15

O?a?eii-aai a/e 2,59(0,09 3,12(0,13* 2,85(0,10 2,79(0,09 2,82(0,10

* I?ei?oea: — aeinoia??i?noue ??cieoe? i?e ii??aiyii? c ai?noii o
eiio?ieueiiio

oeeee? /p<0,05/ Oaaeeoey 4 Aeeiai?ea ci?i a?io?i?/ieo iieaciee?a o ae?iie iniiaii? a?oie, oai?eo ia ooaa?eoeueic eaaaiue, ia oii? canoinoaaiiy ia?aeiio Iacaa iieacieea Aei aaeea. I?aeueiia eiio?aoeai-oeao Oa?i?i aaeeaaiiy i?aeueiiai eiio?aoeaioeao 3 i?nyoe? 6 i?nyoe?a 9 i?nyoe?a 12 i?nyoe?a Oieanoa?ei iiieue/e 3,74(0,13 4,0(0,13* 4,16(0,13 3,96(0,13 3,89(0,13 Caaaeueiee a?eie a/ e 73,38(1,11 74,98(1,10 77,03(0,72* 76,98(1,04* 75,07(0,97* Aeueaoi?ie % 52,65(0,95 51,92(0,82 51,55(0,74 51,03(0,70 51,14(0,70 Caaaeueiee a?e??oa?i ieiieue/ e 6,53(0,34 6,76(0,33 6,17(0,33 5,54(0,30* 5,72(0,31 Iai?yiee a?e??oa?i ieiieue/ e 2,54(0,13 2,24(0,11 2,33(0,11 2,45(0,12 2,34(0,11 O?a?eii-aai a/e 2,46(0,10 2,82(0,10* 2,93(0,10* 2,68(0,08 2,59(0,09 * I?ei?oea: - aeinoia??i?noue ??cieoe? i?e ii??aiyii? c ai?noii o eiio?ieueiiio oeeee? /?<0,05/ ___________________________________________________________________ eoeueic eaaaiue iiaea aooe ca'ycaii c o?eaaeei aaeeaaiiyi niaoeeo?/ieo aioeaaeoa??aeueieo i?aia?ao?a. Oea iio?aao? ?aoaeueiiai iaaeyaeo ca oai?eie ? eiio?ieth eiaaoeia?aie e?ia? ia 3 ? 6 i?nyoeyo aaeeaaiiy i?aia?aoo. Ie ?aeiiaiaeo?ii c iaoith i?io?eaeoeee o?iiaiaiaie?/ieo oneeaaeiaiue o oai?eo, aaeeaath/eo i?aeuei? eiio?aoeaioeae, i?ecia/aoe ani??ei a na?aaei?o aeicao (0,33 a) c o?aoueiai i?nyoey aaeeaaiiy ia?- aeiio. Aeey aecia/aiiy ai?iiiaeueiiai noaoono ae?iie, oai??th/eo ??cii- iai?oieie oi?iaie ooaa?eoeueico eaaaiue, ? noaeaeaiiy i?i ooieoe?th y?/iee?a ie aecia/aee ai?no 17-(-ano?aae?ieo ? i?iaanoa?iio a ieaci? e?ia?. Aeine?aeaeaiiy i?iaaaeaii o 10 ae?iie c ??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue ? o 10 caei?iaeo ae?iie (eiio?ieueia a?oia) aei aaeeaaiiy ia?aeiio. Aecia/aiiy ai?iii?a i?iaiaeeee /ioe?e ?ace i?ae /an iaino?oaeueiiai oeeeeo, eiaeiiai oeaeiy a o?eniaaiee aeaiue (5, 12, 19 26), ui aoei c?o/ii aeey ae?iie, ye? i?eeiaee o/anoue o oaeiio o?eaaeiio ianoaaeaii?. sse iieacaee iao? aeine?aeaeai- iy, aei ii/aoeo aaeeaaiiy eiio?aoeaioeao ai?no 17-( -ano?aae?ieo a ieaci? e?ia? ae?iie, oai??th/eo ia ooaa?eoeueic eaaaiue, ci?ithaaany a caeaaeiino? a?ae aeiy iaino?oaeueiiai oeeeeo: 101,4 ( 25,13 ia/ie, 216,3( 36,76 ia/ie, 158,1( 18,8 ia/ie, 90,8 ( 28,53 ia/ie. Aia- eia?/i? iieacieee ie io?eiaee i?e ianoaaeaii? caei?iaeo ae?iie (102,3 ( 24,12 ia/ie, 224,4 ( 38,70 ia/ie, 164,2 ( 16,81 ia/ie, 91,2 ( 21,61 ia/ie). Iaea?aeai? ?acoeueoaoe na?ae/aoue i?i aeinoaoith ano?iaaiio iane- /ai?noue oai?eo ia ooaa?eoeueic eaaaiue. I?e aecia/aii? ai?noo i?iaanoa?iio o a?aeiia?aei? aei? iaino?o- aeueiiai oeeeeo a ieaci? e?ia? ae?iie, oai?eo ia ooaa?eoeueic eaaaiue, aei aaeeaaiiy ia?aeiio anoaiiaeaii, ui ??aaiue i?iaanoa?iio ia a?ae??ciyany a?ae aiaeia?/ieo iieaciee?a o caei?iaeo ae?iie ? ci?ith- aaany a caeaaeiino? a?ae aeiy iaino?oaeueiiai oeeeeo: i'yoee aeaiue - 1,05(0,12 ia/ie; aeaaiaaeoeyoee aeaiue - 2,66(0,94 ia/ie; aeaa'yoiaaeoey- oee aeaiue - 9,91(1,6 ia/ie; aeaaaeoeyoue oinoee aeaiue - 4,39(1,49 ia/ie. ??aaiue i?iaanoa?iio a ieaci? e?ia? ae?iie, oai?eo ia ooaa?- eoeueic eaaaiue, na?ae/ea i?i aeinoaoith ai?iiiaeueio iane/ai?noue ? i?i iaoeyoe?th, ui a?aeaoeanue. Oaeei /eiii, o an?o ianoaaeaieo ae?iie, oai?eo ia ooaa?eoeueic eaaaiue, ie aeyaeee aeinoaoith iane/ai?noue ano?iaaiii ? i?iaanoa?i- iii, yea ia a?ae??ciy?oueny a?ae ??aiy oeeo iieaciee?a o caei?iaeo ae?- iie. Aea/aii ai?no ai?iii?a a ieaci? e?ia? ae?iie, oai?eo ia oo- aa?eoeueic eaaaiue, ye? aaeeaaee ia?aeii. ?acoeueoaoe aeine?aeaeaiue iiea- caee, ui aaea ia aeaaiaaeoeyoee aeaiue aaeeaaiiy i?aia?aoo a?aei?/aii aeinoia??ia cieaeaiiy ??aiy 17-( -ano?aae?ieo aei 57,2(6,00 ia/ie (p < 0,01). ??aaiue 17-( -ano?aae?ieo a ieaci? e?ia? ae?iie, ye? oai- ??thoue ia ooaa?eoeueic eaaaiue ? aaeeaath/eo ia?aeii, i?iaeiaaeoaaa cie- aeoaaoeny, ? ia o?aoueiio i?nyoe? aaeeaaiiy i?aia?aoo a?aei?/aii ua a?eueoa i?eai?/aiiy ano?iaaiii? aeoeaiino? aei 40,4(3,23 ia/ie. I?e aecia/aii? ai?noo i?iaanoa?iio a ieaci? e?ia? oai?eo ia ooaa?eoeueic ae?iie ia ii/aoeo aaeeaaiiy ia?aeiio aoei oaeiae a?aei?/a- ii, ui nae?aoe?y inoaiiueiai cia/ii cieceeanue aaea ia ia?oiio i?nyoe? aaeeaaiiy eiio?aoeaioeao ? ia aeaa'yoiaaeoeyoee aeaiue iaino?oaeueiiai oeeeeo noaiiaeea 1,65(0,13 ia/ie (p < 0,01). ?c ya?eueoaiiyi o?eaaeino? aaeeaaiiy eiio?aoeaioeao iaie a?aei?- /aii iiaeaeueoa cieaeaiiy eiioeaio?aoe?? i?iaanoa?iio, iaeieae/ee ??- aaiue yeiai niinoa??aaany ia oinoiio i?nyoe? ? aoa ia aeaa'yoiaaeoey- oee aeaiue 0,62(0,09 ia/ie. Iecueeee ai?no i?iaanoa?iio a ieaci? e?ia? oai?eo ae?iie, aaeeaath/eo ia?aeii, na?ae/ea i?i ianoaiiy aiiao- eyoi?ieo iaino?oaeueieo oeeee?a. A nai?e ?iaio? ie oaeiae aecia/aee cai?ioi?noue ae?? i?aeueiiai eiio?aoeaioeao ia?aeiia ia aiaeie?eiio ooieoe?th y?/iee?a ae?iie, oai- ??th/eo ??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue. Aeey oeueiai ie i?iaaee aeine?aeaeaiiy ai?iiiaeueiiai noaoono oai?eo ia ooaa?eoeueic eaaaiue ae?iie i?ney a?aei?ie aaeeaaiiy eiio?aoeaioeao. Aecia/aiiy ai?iii?a i?iaiaeeee a e?ia? oai?eo ia o?aoueiio i?nyoe? i?ney cae?i- /aiiy eo?no aaeeaaiiy eiio?aoeaioea?a. sse na?ae/aoue iaea?aeai? ?a- coeueoaoe, a e?ia? oai?eo ae?iie i?ney a?aei?ie aaeeaaiiy ia?aeiio ianoa? aeinoia??ia i?aeaeuaiiy nae?aoe?? 17-(-ano?aae?ieo. Ai?no 17-(-ano?aae?ieo a ieaci? e?ia? noaiiaea ia i'yoee aeaiue iaino?o- aeueiiai oeeeeo 95,24(18,9 ia/ie, ia aeaaiaaeoeyoee aeaiue 236,3(31,37 ia/ie, ia aeaa'yoiaaeoeyoee aeaiue 157,8(16,3 ia/ie ? ia aeaaaeoeyoue oin- oee aeaiue oeeeeo 79,5(16,8 ia/ie. Oaeei /eiii, ??aaiue 17-(-ano?aae?- ieo a ieaci? e?ia? ae?iie, oai??th/eo ??ciiiai?oieie oi?iaie ooaa?- eoeueico eaaaiue, ye? aaeeaaee i?ioyaii aeaaiaaeoeyoe iaino?oaeueieo oeeee?a i?aeueiee eiio?aoeaioea ia?aeii, ia o?aoueiio i?nyoe? i?ney a?aei?ie i?aia?aoo iiai?noth a?aeiiaeth?oueny ? ia a?ae??ciy?oueny a?ae ??aiy 17-(-ano?aae?ieo ieacie e?ia? oe??? a?oie ae?iie ia?aae canoi- noaaiiyi ia?aeiio. Aiaeia?/i? ci?ie aeyaeai? iaie i?e aecia/aii? ??aiy i?iaanoa?iio ieacie e?ia? ae?iie, oai?eo ??ciiiai?oieie oi?- iaie ooaa?eoeueico eaaaiue, i?ney a?aei?ie eiio?aoeaioeao. Oae, ia o?aoueiio i?nyoe? i?ney a?aei?ie ia?aeiio ianoaei cia/ia i?aeaeuaiiy ai?noo i?iaanoa?iio a ieaci? e?ia? i?e ii??aiyii? c ai?noii, yeee niinoa??aaany i?ae /an aaeeaaiiy eiio?aoeaioeao, ? ia aeaa'yoiaaeoeyoee aeaiue a?i noaiiaea 10,0(1,64 ia/ie. I?e ii??aiyii? c eiio?ieueiei oeeeeii aeinoia??ii? ??cieoe? ia ciaeaeaii (p > 0,05). Oaeei /eiii,

??aaiue i?iaanoa?iio ieacie e?ia? ae?iie, oai?eo ??ciiiai?oieie

oi?iaie ooaa?eoeueico eaaaiue, ye? aaeeaaee i?ioyaii aeaaiaaeoeyoe iai-

no?oaeueieo oeeee?a i?aeueiee eiio?aoeaioea ia?aeii, ia o?aoueiio i?ny-

oe? i?ney a?aei?ie i?aia?aoo ia a?ae??ciyany a?ae ??aiy i?iaanoa?iio

ieacie e?ia? oe??? a?oie ae?iie a eiio?ieueiiio oeeee? ia?aae canoino-

aaiiyi ia?aeiio.

Oaeei /eiii, aiae?coth/e i?iaaaeai? iaie ai?iiiaeuei? aeine?ae-

aeaiiy ai?noo 17-(-ano?aae?ieo ? i?iaanoa?iio a ieaci? e?ia? o ae?-

iie, oai?eo ??ciiiai?oieie oi?iaie ooaa?eoeueico eaaaiue, ? o caei-

?iaeo ae?iie ia?aae canoinoaaiiyi i?aeueiiai eiio?aoeaioeao ia?aeii,

i?ae /an aaeeaaiiy i?aia?aoo i?ioyaii ia?oiai, o?aoueiai ? oinoiai

iaino?oaeueieo oeeee?a, a oaeiae i?ae /an o?aoueiai iaino?oaeueiiai

oeeeeo i?ney a?aei?ie ia?aeiio, iiaeia c?iaeoe oae? aeniiaee.

O a?eueoino? ae?iie, oai??th/eo ??ciiiai?oieie oi?iaie ooaa?-

eoeueico eaaaiue, aiaeie?eiia ooieoe?y y?/iee?a ia ii?ooaia, i?i ui

na?ae/eoue ??aaiue 17-(-ano?aae?ieo ? i?iaanoa?iio ieacie e?ia?, yeee

nooo?ai ia a?ae??ciy?oueny a?ae ai?noo oeeo ai?iii?a o caei?iaeo

ae?iie. A?aoiaoth/e iaaaoeaiee aieea aaa?oiino? ia ia?aa?a aeaiiai

caoai?thaaiiy, oai?? ia ooaa?eoeueic eaaaiue ae?iee iiaeii? aeei?en-

oiaoaaoe ai?iiiaeuei? eiio?aoeaioeae.

I?ae /an canoinoaaiiy i?aeueiiai eiio?aoeaioeao ia?aeii caei?iae-

ie ae?ieaie ? ae?ieaie, oai??th/eie ??ciiiai?oieie oi?iaie ooaa?eo-

eueico eaaaiue, aeieea? i?eai?/aiiy nae?aoi?ii? ooieoe?? y?/iee?a.

I?i oea na?ae/eoue iecueeee ??aaiue 17-(-ano?aae?ieo ? i?iaanoa?iio a

ieaci? e?ia?, ui niinoa??aaany i?ae /an aaeeaaiiy eiio?aoeaioeao.

I?eai?/aiiy iaoeyoe?? caaacia/o? iaae?ei?noue eiio?aoeaioe?? o ae?iie

oeeo a?oi.

I?ney a?aei?ie ia?aeiio o ae?iie, oai??th/eo ??ciiiai?oieie oi?-

iaie ooaa?eoeueico eaaaiue, ianooia? iiaia a?aeiiaeaiiy nae?aoi?ii?

ooieoe?? y?/iee?a. Ia o?aoueiio i?nyoe? i?ney a?aei?ie i?aeueiiai eii-

o?aoeaioeao ??aaiue 17-(-ano?aae?ieo ? i?iaanoa?iio a ieacie e?ia?

aeinyaa? aeno?aeieo aeaieo ? i?aeoe/ii ia a?ae??ciy?oueny a?ae ??aiy

oeeo ai?iii?a a eiio?ieueiiio oeeee?, ui na?ae/eoue i?i a?aeiiaeaiiy

oa?oeeueiino? o ae?iie oe??? a?oie.

AENIIAEE

1. O 87,2% ae?iie, oai??th/eo ??ciiiai?oieie oi?iaie ooaa?eo-

eueico eaaaiue, caa?aaeaia iaino?oaeueia ? ?ai?iaeoeoeaia ooieoe??, a

??aaiue 17-(-ano?aae?ieo ? i?iaanoa?iio a ieacie e?ia? nooo?ai ia

a?ae??ciy?oueny a?ae ??aiy oeeo ai?iii?a o caei?iaeo ae?iie. Aeey caii-

a?aaiiy aaa?oiino? a?eueo?noue ae?iie, oai?eo ia ooaa?eoeueic eaaaiue,

iiaeii? canoiniaoaaoe ai?iiiaeuei? iaoiaee eiio?aoeaioe??.

2. I?iaaaeai? ee?i?/i? niinoa?aaeaiiy ii aea/aiith eiio?aoeai-

oeaii? aoaeoeaiino? ? /anoioe oneeaaeiaiue i?e o?eaaeiio canoino-

aaii? ia?aeiio, ?eaaa?aeiio ? eiio?io?io iieacaee, ui iaea?eueoo

aoaeoeai?noue ? aacia/i?noue aeey aeaii? eaoaai??? oai?eo ia? ia?aeii.

3. I?e aeei?enoaii? i?aeueiiai eio?aoeaioeao ia?aeiio i?ioyaii

9-12 i?nyoe?a ae?ieaie, oai?eie ia ooaa?eoeueic eaaaiue, a?aei?/aii

aeinoia??ia cieaeaiiy ai?noo noaoaaeo ai?iii?a, — oea na?ae/eoue i?i

iiaia i?eai?/aiiy iaoeyoe??, ui caaacia/o? iaae?ei?noue eiio?aoeaioe??

(100% eiio?aoeaioeaia aoaeoeai?noue).

4. Iniiai? iieacieee a?eeiaiooai?thth/i?, i?aiaioii? ooieoe??

ia/?iee nooo?ai ia ci?iththoueny ia i?ioyc? aaeeaaiiy ia?aeiio ? ia

a?ae??ciythoueny a?ae aiaeia?/ieo iieaciee?a a a?oi? caei?iaeo ae?iie.

5. I?e canoinoaaii? ia?aeiio o ae?iie, ye iniiaii?, oae ? eii-

o?ieueii? a?oi, a e?ioe? o?aoueiai i?nyoey niinoa??aa?oueny i?aeaeuaiiy

ai?noo o?a?eiiaaio, a ieaci? e?ia?, aea yeui a eiio?ieuei?e a?oi?

i?ioyaii ianooiieo o?ueio i?nyoe?a ia? i?noea ii?iae?caoe?y ??aiy

o?a?eiiaaio, oi o ae?iie iniiaii? a?oie oeueiai ia a?aeaoaa?oueny, ui

iio?aao? i?io?eaeoeee o?iiaiaiaie?/ieo oneeaaeiaiue.

6. Ia o?aoueiio i?nyoe? i?ney a?aei?ie ia?aeiio ia? i?noea ii?-

iae?caoe?y ai?noo ano?iaai?a ? i?iaanoa?iio a e?ia? ae?iie iniiaii?

oa eiio?ieueii? a?oi, ui aeaco? ia iiaia a?aeiiaeaiiy o ieo ooieoe?-

iiaeueiiai noaio y?/iee?a ? oa?oeeueiino?.

7. Ia i?aenoaa? i?iaaaeaieo iaie aeine?aeaeaiue ie ?aeiiaiaeo?ii c

iaoith eiio?aoeaioe?? aeei?enoaiiy ia?aeiio ae?ieaie, ye? oai??thoue ia

ooaa?eoeueic eaaaiue, i?ae eiio?ieai eiaaoeia?aie e?ia?. Iioeiaeueia

o?eaae?noue canoinoaaiiy ia?aeiio noaiiaeoue 9-12 i?nyoe?a c ianooi-

iei i?aeai?ii ?ioeo iaoiae?a eiio?aoeaioe??.

I?AEOE*I? ?AEIIAIAeAOe??

Ia i?aenoaa? i?iaaaeaieo iaie aeine?aeaeaiue ie i?iiiio?ii:

1. A ca’yeo c aaeeeith e?euee?noth iaaaaeaieo aoaeo?a ia ?aei-

iaiaeo?ii aeei?enoiaoaaoe c eiio?aoeaioeaiith iaoith ae?ieaie, ye?

oai??thoue ia ooaa?eoeueic eaaaiue, oae? i?aeuei? eiio?aoeaioeae, ye

?eaaa?aeii ? eiio?io?i.

2. AE?iee ae?oi??aeiiai a?eo, oai?? ia ooaa?eoeueic eaaaiue, c

iaoith eiio?aoeaioe?? iiaeooue aeei?enoiaoaaoe ano?iaaii-aanoaaaiiaee

i?aia?ao ia?aeii (a iaei?e oaaeaooe? i?noeoueny 0,25 ia eaaiii?aano-

?aeo ? 0,05 ia aoei?eano?aae?ieo).

3. A ia?o? i?nyoe? aaeeaaiiy ia?aeiio iio??aii i?iaiaeeoe ?a-

oaeueiee iaaeyae ca oai?eie — eiio?ieue eiaaoeia?aie e?ia? ia

o?aoueiio i?nyoe? aaeeaaiiy i?aia?aoo c iaoith i?io?eaeoeee iiaeeeaeo

iaaaaeaieo aoaeo?a. I?e i?aeaeuaii? iieaciee?a cai?oath/i? nenoaie

e?ia? ?aeiiaiaeo?oueny i?ecia/aiiy ani??eio a na?aaei?o oa?aiaaoe/-

ieo aeicao (0,33 a) i?ioyaii i?nyoey.

4. Aeooa?-a?iaeieia iiaeiai iai’yoaoe i?i i?aeaeuaiee ?ecee

?icaeoeo eaiae?aeicieo eieuei?o?a o ae?iie, oai?eo ia ooaa?eoeueic ea-

aaiue, ui iio?aao? i?iaaaeaiiy i?io?eaeoe/ieo ? e?ea?nueeeo caoiae?a.

5. Ia o?aoueiio i?nyoe? i?ney a?aei?ie ia?aeiio o ae?iie, oai?eo

ia ooaa?eoeueic eaaaiue, ianooia? iiaia a?aeiiaeaiiy ooieoe?iiaeueiiai

noaio y?/iee?a. C iaoith iiia?aaeaeaiiy iaaaaeaii? aaa?oiino? iaia-

o?aeiee i?aea?? ?ioeo iaoiae?a eiio?aoeaioe??.

NIENIE IAOEIAEO ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

1. AEeaaaeei A.A. Canoinoaaiiy i?aeueiiai eiio?aoeaioeao «ia?-

aeii» o ae?iie c ooaa?eoeueicii eaaaiue //Oa?iaoeaaoe/iee aeo?iae. —

1999. — N1. — N.93-95.

2. AEeaaaeei A.A. Ee?i?/ia iaa?oiooaaiiy aeai?o i?aeueieo eiio-

?aoeaioea?a aeey ae?iie, ye? oai??thoue ia ooaa?eoeueic eaaai?a //E?ee.

— 1998. — N3. — N.85-89.

3. A?oaiiiia A.N., AEeaaaeei A.A. Ee?i?ei-eaai?aoi?ia iaa?oi-

ooaaiiy canoinoaaiiy c iaoith eiio?aoeaioe?? ia?aeiio o ae?iie c oo-

aa?eoeueicii eaaaiue //Iaae?ao??y, aeooa?noai oa a?iaeieia?y. —

1991. -N6. — N.54-55.

4. Gigadlo B., Binagana P., Artamonov V. L’application du

contraceptif oral Microgenon 50 chez les femmes tuberculeuses

//Revue medicale de Bujumbura. — 1989. — N7. — P.39-40

5. Gigadlo B., Artamonov V., Issakov B. L’application du

contraceptif oral Ovidon chez les femmes tuberculeuses

//Materiaux de la conference scientifique et pratique des

medecins sovietiques et Burundais. — Bujumbura (Burundi). — 1989.

— P.19-21.

6. Artamonov V., Gigadlo B., Sayinzoga. Les contraceptifs

oraux et la tuberculose pulmonaire //Materiaux de la conference

scientifiques et pratique des medecins sovietiques et Burundais.

— Bujumbura (Burundi). — 1989. — P.30-31.

AEeaaaeei A. «Ee?i?ei-eaai?aoi?ia iaa?oiooaaiiy i?aeai?o iioe-

iaeueieo iaoiae?a eiio?aoeaioe?? aeey ae?iie c ooaa?eoeueicii eaaaiue».

?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo

iaoe ca niaoe?aeuei?noth 14.01.01. — Aeooa?noai oa a?iaeieia?y. —

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao, Ee?a, 1998.

I?iaaaeaia ee?i?/ia ai?iaaoe?y i?aeueieo eiio?aoeaioea?a ? iioe-

iaeueiee aea?? (ia?aeii, ?eaaa?aeii, eiio?io?i) o ae?iie, oai?eo ia

ooaa?eoeueic eaaaiue. Aea/aii noai iniiaieo ooieoe?e ia/?iee, cai?-

oath/i? nenoaie e?ia?, aiaeie?eiii? ooieoe?? y?/iee?a o ae?iie, oai-

?eo ia ooaa?eoeueic eaaaiue, i?ae /an aaeeaaiiy ia?aeiio, oaeiae aea/a-

ii noai aiaeie?eiii? ooieoe?? y?/iee?a i?ney i?eieiaiiy aaeeaaiiy

i?aia?aoo. Anoaiiaeaii, ui iaeaeua aoaeoeai?noue eiio?aoeaioe?? ?

iaea?eueo ni?eyoeeaee ee?i?/iee aoaeo iaee i?noea i?ae /an canoino-

aaiiy ia?aeiio. Iiaia a?aeiiaeaiiy aiaeie?eiii? ooieoe?? y?/iee?a o

ae?iie, oai?eo ia ooaa?eoeueic eaaaiue, a?aeaoaa?oueny ia o?aoueiio

i?nyoe? i?ney a?aei?ie i?aeueiiai eiio?aoeaioeao. Canoinoaaiiy ia?aei-

io ae?ieaie, ye? oai??thoue ??ciiiai?oieie oi?iaie ooaa?eoeueico ea-

aaiue, aeicaieeoue oieeiooe aaa?oiino? i?ae /an e?eoaaiiy aeaiiai cao-

ai?thaaiiy.

Eeth/ia? neiaa: i?aeuei? eiio?aoeaioeae, ooaa?eoeueic eaaaiue,

i?iaanoa?ii, 17-(-ano?aae?ie, o?a?eiiaai, aeueaoi?i, caaaeueiee a?-

eie, oieanoa?ei, caaaeueiee ? iai?yiee a?e??oa?i.

AEeaaaeei A. «Eeeieei-eaai?aoi?iia iainiiaaiea iiaeai?a iioe-

iaeueiuo iaoiaeia eiio?aoeaioeee aeey aeaiuei n ooaa?eoeacii eaaeeo». —

?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeein-

eeo iaoe ii niaoeeaeueiinoe 14.01.01. — Aeooa?noai e aeiaeieiaey. —

Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao, Eeaa, 1998.

?aaioa iinayuaia iiaeai?o iaeaieaa yooaeoeaiuo e aaciianiuo

i?aeueiuo eiio?aoeaioeaia aeey aeaiuei, no?aaeathueo ?acee/iuie oi?ia-

ie ooaa?eoeueica eaaeeo.

Ianeaaeiaaii 150 aeaiuei a aic?anoa io 19 aei 40 eao n iniiaiu-

ie oi?iaie ooaa?eoeaca eaaeeo (i/aaiaue, aeenaieie?iaaiue, eioeeue-

o?aoeaiue). Eco/aii ninoiyiea iniiaiuo ooieoeee ia/aie, naa?ouaath-

uae nenoaiu e?iae, yiaeie?eiiie ooieoeee ye/ieeia o aeaiuei, aieueiuo

ooaa?eoeacii eaaeeo. Onoaiiaeaii, /oi o 87,2% aeaiuei, aieathueo

?acee/iuie oi?iaie ooaa?eoeaca eaaeeo, nio?aiaia iaino?oaeueiay e

?ai?iaeoeoeaiay ooieoeee e ei iieacai aeeeoaeueiue i?eai ai?iiiaeueiuo

eiio?aoeaioeaiuo i?aia?aoia.

Aia?aua i?iaaaeaia eeeie/aneay ai?iaaoeey e auai? i?aeueiuo

eiio?aoeaioeaia (iaeaeii, ?eaaaeaeii, eiioeioei) o aeaiuei, aieueiuo

ooaa?eoeacii eaaeeo.

Ai a?aiy i?eaia iaeaeiia i?iaiaeeeinue eco/aiea yiaeie?eiiie

ooieoeee ye/ieeia, naa?ouaathuae nenoaiu e?iae e iniiaiuo ooieoeee

ia/aie. Ioia/aii, /oi o aeaiuei, aieueiuo ooaa?eoeacii eaaeeo, i?e

eniieueciaaiee i?aeueiiai iiiioaciiai eiio?aoeaioeaa iaeaeii i?ienoi-

aeeo aeinoiaa?iia nieaeaiea 17-(-yno?aaeeiea e i?iaanoa?iia a ieacia

e?iae, naeaeaoaeuenoaothuea i iieiii iiaeaaeaiee iaoeyoeee, /oi iaan-

ia/eaaao iaaeaaeiinoue eiio?aoeaioeee (100% eiio?aoeaioeaieue yooaeo).

Ii?aaeaeaii, /oi iniiaiua iieacaoaee aaeeiaiia?aciaaoaeueiie,

ieaiaioiie ooieoeee ia/aie nouanoaaiii ia eciaiythony ia i?ioyaeaiee

i?eaia iaeaeiia e ia ioee/athony io niioaaonoaoueo iieacaoaeae a

a?oiia caei?iauo aeaiuei. Aia?aua onoaiiaeaii, /oi naiay aunieay

eiio?aoeaioeaiay yooaeoeaiinoue e iaeaieaa aeaaii?eyoiue eeeie/an-

eee yooaeo iaaethaeaaony ai a?aiy i?eaia iaeaeiia, oaeaea ioia/aii,

/oi iaeaeii ia ieacuaaao io?eoeaoaeueiiai aeeyiey ia oa/aiea ooaa?-

eoeaciiai i?ioeanna a eaaeeo. Aeieacaii, /oi eiioeaio?aoeey oea?eii-

aaia a e?iae aeaiuei, aieueiuo ooaa?eoeacii eaaeeo, iiauoaaony ia

o?aoueai ianyoea i?eaia iaeaeiia, ii ia i?aauoaao aa?oieo a?aieoe

ii?iu.

O aeaiuei, aieueiuo ooaa?eoeacii eaaeeo, i?eieiaaoeo a oa/aiea

12 ianyoeaa n eiio?aoeaioeaiie oeaeueth iaeaeii, ia o?aoueai ianyoea
iin-

ea aai ioiaiu eco/aii niaea?aeaiea 17-(-yno?aaeeiea e i?iaanoa?iia a

ieacia e?iae. Ioia/aia ii?iaeecaoeey niaea?aeaiey yoeo ai?iiiia, /oi

oeacuaaao ia iieiia ainnoaiiaeaiea o ieo ooieoeeiiaeueiiai ninoiy-

iey ye/ieeia e oa?oeeueiinoe.

I?eiaiaiea iaeaeiia aeaiueiaie, no?aaeathueie ?acee/iuie oi?iaie

ooaa?eoeaca eaaeeo, iicaieeo ecaaaeaoue aa?aiaiiinoe ai a?aiy ea/a-

iey aeaiiiai caaieaaaiey.

Eeth/aaua neiaa: i?aeueiua eiio?aoeaioeau, ooaa?eoeac eaaeeo,

i?iaanoa?ii, 17-(-yno?aaeeie, oea?eiiaai, aeueaoiei, iauee aaeie,

oieanoa?ei, iauee e iai?yiie aeee?oaei.

Gigadlo B. «Clinical-laboratory Grounds of the Selection of

the Optimum Contraceptive Methods for the Women who are ill with

Tuberculosis of the Lungs».

Manuscript.

A dissertation for the degree of Candidate of Medical

science of the spesiality 14.01.01.- Obstetrics and Gynaecology.-

National Medical University. Kiev. 1998.

The clinical approbation and the optimum selection of the

contraceptives (ovidon, regividon, continuin) for women with

pulmonary tuberculosis have been done. The state of the main

functions of the liver, of the coagulative blood system, of the

endocrine ovarian function of the women with pulmonary

tuberculosis during taking ovidon has been studied. The state of

the endocrine ovarian function has also been studied after

stopping taking ovidon. It was realized that the highest

effectiveness of the contraceptives and the best clinical effect

were observed during taking ovidon.

The complete restoration of the endocrine ovarian function of the

women with pulmonary tuberculosis are observed on the third month

after stopping taking oral contraceptives. Taking ovidon by the

women who are ill with pulmonary tuberculosis prevents pregnancy

during the treatment for this illness.

Key words: oral contraceptives, pulmonary tuberculosis,

progesterone, 17-(-estradiol, fibrinogen, albumin, common protein

(albumen), cholesterol, common and inderect bilirubin.

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