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Клініко-імунологічні особливості виразкової хвороби дванадцятипалої кишки при комплексній терапії з включенням вітаміну Е та ехінацеї пурпурної: Автор

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I?I?NOA?NOAI IOI?IIE CAeI?IAss OE?A?IE

?AAII-O?AIE?ANUeEA AeA?AEAAIA IAAeE*IA AEAAeAI?ss

Ia i?aaao ?oeiieno

IAOOUAE IEUeAA IEEIEA?AIA

OAeE: 616. 342–002.44–085.356–085.322–092.19

EE?I?EI–?IOIIEIA?*I? INIAEEAINO? AE?ACEIAI? OAI?IAE AeAAIAAeOessOEIAEI?
EEOEE I?E EIIIEAENI?E OA?AI?? C AEETH*AIIssI
A?OAI?IO A OA AO?IAOeA? IO?IO?II?

14.01.02 AIOO??OI? OAI?IAE

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

?AAII–O?AIE?ANUeE – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?iai? Aeaieea Aaeeoeueeiai.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Aeooea ?iiai ss?ineaaiae/,

Euea?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao

?iai? Aeaieea Aaeeoeueeiai IIC
Oe?a?ie,

caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia

Io?oe?ei? iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani? I?uoe Aaneeue A?eai?iae/,

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie,

i?ioani? eaoaae?e oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

2. Aeieoi? iaaee/ieo iaoe, i?ioani? Aiio?ia Aaeeia Aiaoie??aia,

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?iai? I.E. Ooieea
IIC Oe?a?ie,

i?ioani? eaoaae?e aano?iaioa?ieia?? oa ae??oioa?ai??

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee
oi?aa?neoao

?i. aeaaeai?ea
I.I.Aiaiiieueoey,

eaoaae?a
aini?oaeueii? oa?ai?? ? 2 (i. Ee?a)

Caoeno a?aeaoaeaoueny _30_” _ea?oiy_ 1999 ?ieo ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 20.601.01. o ?aaii-O?aie?anuee?e
aea?aeaai?e iaaee/i?e aeaaeai?? (284000, i. ?aaii-O?aie?anuee, aoe.
Aaeeoeueea, 2).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?aaii-O?aie?anueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (284000, i.?aaii-O?aie?anuee,
aoe.Aaeeoeueea, 7).

Aaoi?aoa?ao ?ic?neaiee __19 aa?aciy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani?
I. A. I?ei/ae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia ae?aceiai? oai?iae aeaaiaaeoeyoeiaei?
eeoee (AOAeIE) ia nueiaiaei? iiai?noth caa??aa? naith aeooaeuei?noue ye
a oai?aoe/iiio, oae ? a i?aeoe/iiio a?aeiioaii?. Ae?aceiaa oai?iaa
caeeoa?oueny iaea?eueo iioe?aiei caoai?thaaiiyi i?aai?a o?aaeaiiy, a ca
inoaii? aeanyoe??//y noaeiny iaa?oue c?inoaiiy caoai?thaaiino?
(Ia?aaea?ee A.A. e niaao., 1997; Aaeaiei C.I., 1995).

I?eioeeiia? ieoaiiy ao?ieia??, iaoiaaiaco, ae?aaiinoeee oa e?eoaaiiy
ae?aceiaeo o?aaeaiue aano?iaeoiaeaiaeueii? ciie aeoeaii aeeneooothoueny
a iaoeia?e e?oa?aoo??, i?ioa caeeoathoueny aeaeaeeie a?ae inoaoi/iiai
c’ynoaaiiy. O?ii?/ia ?aoeeaeeaoth/a i?io?eaiiy, iie?ii?o?ci ee?i?/ieo
i?iya?a ? aaaee? oneeaaeiaiiy ae?aceiai? oai?iae 12-iaei? eeoee, a
oaeiae cynoaaiiy ?ie? oae?eiaaeoa?ii? ?ioaeoe?? a ?icaeoeo caoai?thaaiiy
aeacothoue ia caoe?eaaeai?noue ?ioiii? nenoaie a aaiac? oai?iae.

Iane?aeie oiai /e ?ioiai iaoieia?/iiai i?ioeano a e?ioeaaiio i?aenoieo
aecia/a?oueny ye oni?oiei e?eoaaiiyi, oae ? noaiii iae?ii?aai?cio, eiai
?aaeoeai?noth. Oi?ioaaiiy O-ee?oeiiiai ?ioiiaeao?oeeoo, ia?aaaaeii ca
?aooiie cieaeaiiy ??aiy O-oaeia??a ia oii? i?aeaeuaiiai ??aiy Ig A ?
ca?eueoaiiy ai?noo A-e?ioioeeo?a, i?aeaeuaiiy ??aiy oee?eoethth/eo
?ioiieo eiiieaen?a (Oe?E) oa ??aiy I-e?ioioeeo?a oa?aeoa?i? aeey AOAeIE
? iinyoue ianiaoeeo?/iee oa?aeoa? (Ia?aaea?ee A.A. e niaao., 1997;
Aeaaoy?ueiaa ?.?. ? ni?aaao., 1992; Iaeauoe A.I. ? ni?aaao., 1995; Kluge
A. et al., 1993; Begum S. et al., 1992). Ia aeeaey/enue ia iayai?noue
ci?i ?ioiii? nenoaie, a?aenooi? aeai? uiaei /?oeiai iaa?oiooaaiiy
canoinoaaiiy ?ioiiiiaeoethth/i? oa?ai?? i?e ae?aceia?e oai?ia? ? a
?acoeueoao? oeueiai iica oaaaith caeeoa?oueny iaeia c iaea?eueo
aaaeeeaeo nenoai — ?ioiia nenoaia.

Caaaeueiia?aeiii, ui a e?eoaaii? ae?aceiai? oai?iae, a iniiaiiio,
aeei?enoiaothoueny na?aaeieee, aeieoth/? eeneioiaeae?eaiiy, ci?ie yeiai
? iaeiei ?c e?ioeaaeo iane?aee?a ii?ooaiiy ??cieo iaoai?ci?a,
aeeth/ath/e ?ioii?. I?ioa, aei oeueiai /ano iaaeinoaoiuei aea/aiee aieea
?ioiiiiaeoeyoi??a ia iieacieee ?ioiiiai noaio oai?eo AOAeIE. Na?aae
?ioiiiiaeoethth/eo cania?a i?e e?eoaaii? ??cieo caoai?thaaiue iaea?eueo
aea/aieie ? ioeea?iao iao??th, O-aeoea?i, a?eicai, c?eni?ei, o?iae?i
(Naethe I.E., 1992; Eaoa?ai/oe ?.I., 1996; Aeoaea?ue E.A., 1994; Ia?eea
E.I., 1991). I?ioa oe? i?aia?aoe ia iicaaaeai? iia?/ieo aoaeo?a, ui
iaiaaeo? ?o aaeeaaiiy, iniaeeai o oai?eo ae?aceiaith oai?iaith, yea
/anoi niinoa??aa?oueny o in?a iieiaeiai oa na?aaeiueiai a?eo.

Iaeieie ?c iaea?eueo aacia/ieo e?eoaaeueieo na?aaeiee?a ?
o?oina?aaeieee oa i?e?iaei? aioeieneaeaioe (*aeiai ?.N., 1996).

Na?aae aeaii? a?oie caneoaiao? oaaae a?o/eciyiee i?aia?ao ianoieea
ao?iaoea? io?io?ii?, aoaeoeai?noue yei?, ye ?ioiiiiaeoeyoi?a, aeiaaaeaia
i?e oe?eiio ?yae? caoai?thaaiue, aeeth/ath/e a??oni?, ?aaiaoi?aeiee
a?o?eo, oeoe?iaee ae?aaao, o?ii?/iee aeiia?oeiiao?eo (Iaoiiaa I.?.,
1997; Zoutewelle G., 1990; Aeoae/aiei E.A., 1991; Iai/o? O.?., 1993).
I?ioa, ii a?aeiioaiith aei AOAeIE aoaeoeai?noue aeaiiai caniao a
ee?i?oe? ia aea/aeany.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia ca?aeii c ieaiii IAe? Euea?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?iai? Aeaieea Aaeeoeueeiai Ae? ?I.25.01.0003.96
I?iaiicoaaiiy i?ia?aae??ioiino? o?ii?/ieo caoai?thaaiue”.

Iaoith aeaiiai aeine?aeaeaiiy ? aea/aiiy aoaeoeaiino? eiiieaenii?
oa?ai?? c aeeth/aiiyi ?ioiiiiaeoeyoi?a ianoieee ao?iaoea? io?io?ii? oa
a?oai?io A (-oieioa?ieo aoeaoaoo) ia ee?i?ei-?ioiieia?/i? iieacieee o
oai?eo ae?aceiaith oai?iaith 12-iaei? eeoee.

O a?aeiia?aeiino? c iinoaaeaiith iaoith, aecia/ai? caaaeaiiy
aeine?aeaeaiiy

1. I?iaanoe aea/aiiy ?ioiiiai noaio oai?eo c AOAeIE ii iieacieeao
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E), oieiaeiaeo ?ioiieo eiiieaen?a
(O?E), ne?iaaoei-noi?ani?iiai oaeoi?o (NNO) oa ?ioii?aaoeyoi?iiai
?iaeaeno (???) a ne?iaaooe? e?ia?.

2. I?iaanoe aiae?c ?ioiieia?/ieo iieaciee?a Oe?E, O?E, NNO oa ??? o
oai?eo c AOAeIE a caeaaeiino? a?ae a?eo, o?eaaeino? caoai?thaaiiy,
aaaeeino? oa aaee/eie ae?aceiaiai aeaoaeoo.

3. Aea/eoe aieea aacenii? i?ioeae?aceiai? oa?ai?? ia ?ioiiee noai
oai?eo AOAeIE.

4. Aea/eoe aieea eiiieaenii? oa?ai?? c aeeth/aiiyi ?ioiiiiaeoeyoi?a
ao?iaoea? io?io?ii? oa -oieioa?ieo aoeaoaoo ia ai?no Oe?E, O?E, NNO oa
??? a ne?iaaooe? e?ia? oai?eo AOAeIE.

5. I?iaanoe ii??aiyeueiee aiae?c ee?i?ei-aiaeineii?/ii-?ioiieia?/ii?
aoaeoeaiino? eiiieaenii? oa?ai?? c aeei?enoaiiyi ianoieee ao?iaoea?
io?io?ii? oa a?oai?io A c aaceniith i?ioeae?aceiaith oa?ai??th o oai?eo
AOAeIE.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa a oiiaao ee?i?ee
anoaiiaeaii, ui caaino?aiiy AOAeIE noi?iaiaeaeo?oueny ?ioiieia?/iei
aeenaaeainii, yeee oa?aeoa?eco?oueny ia o?eueee cieaeaiiyi
?ioii?aaoeyoi?iiai ?iaeaeno, i?aeaeuaiiyi Oe?E, aea e ca?eueoaiiyi O?E
oa NNO. Aeyaeaii ci?ie ?ioiieia?/ieo iieaciee?a a caeaaeiino? a?ae
aaaeeino? caoai?thaaiiy. Iaa?oioiaaii iaiao?aei?noue i?iaaaeaiiy
?ioii?aaoethth/i? oa?ai?? o oai?eo AOAeIE. Aea/aii aieea eiiieaenii?
oa?ai?? c aeeth/aiiyi ?ioiiiiaeoeyoi?a ?ineeiiiai iioiaeaeaiiy —
ianoieee ao?iaoea? io?io?ii? a ii?aeiaii? c a?oai?iii A ia iieacieee
?ioi?oaoo Oe?E, O?E, NNO oa ??? o oai?eo AOAeIE. Aeiaaaeaia
ee?i?ei-aiaeineii?/ia oa ?ioiieia?/ia aoaeoeai?noue aeacaii? oa?ai?? o
oai?eo AOAeIE.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ia iniia? io?eiaieo
?acoeueoao?a iaa?oioiaaii iiaee i?aeo?ae aei aeai?o iaoiae?a e?eoaaiiy
oai?eo AOAeIE ? aeiaaaeaia ee?i?/ia, aiaeineii?/ia oa ?ioiieia?/ia
aoaeoeai?noue aeeth/aiiy a eiiieaenio oa?ai?th ?ioiiiiaeoethth/iai
na?aaeieea ?ineeiiiai iioiaeaeaiiy — ao?iaoea? io?io?ii? oa a?oai?ia E.
Canoinoaaiiy ?ioiiiiaeoeyoi?a ao?iaoea? io?io?ii? oa aioeieneaeaioa
a?oai?ia A aeicaiey? a a?eueo ei?ioeee oa?i?i aeinyaiooe ee?i?/ii? oa
aiaeineii?/ii? ?ai?n?? ae?aceiai? oai?iae, ciaioeoe e?euee?noue
?aoeeaeea?a caoai?thaaiiy, a oaeiae e?ea?aeoaaoe aoi?eiiee
?ioiiaeao?oeeo, ui ia? i?noea o oeeo oai?eo. Aaaeeeaa i?aeoe/ia cia/aiiy
io?eiaieo ?acoeueoao?a iieyaa? oaeiae a oiio, ui a yeino?
?ioiiiiaeoeyoi??a aeei?enoai? a?o/eciyi?, aeinooii? aeey oai?eo
i?aia?aoe, ye? ? i?e?iaeieie caniaaie c i?i?iaeueiith e?euee?noth
iia?/ieo ae?e, ui ?iaeoue ?o aacia/ieie aeey oe?ieiai canoinoaaiiy a
i?aeoeoe? e?ea?y.

Io?eiai? ?acoeueoaoe aeei?enoiaothoueny a iaa/aeueii–iaaeaaia?/iiio
i?ioean? ia eaoaae?? i?iiaaeaaoeee aioo??oi?o oai?ia Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai.
?acoeueoaoe aeine?aeaeaiue c iiceoeaiei aoaeoii ai?iaaaeaeaii a
i?aeoe/io ae?yeuei?noue aano?iaioa?ieia?/ieo a?aeae?eaiue 1 oa ? 2
e?ea?i? ? 5 i.Eueaiaa, aano?iaioa?ieia?/iiai a?aeae?eaiiy e?ea?i? ? 30
I?inueeiai ?aeiio i. Ee?aa, iaeaniiai ee?i?/iiai aano?iaioa?ieia?/iiai
aeeniaina?o i.Oaeai?iaea oa oa?aiaaoe/iiai a?aeae?eaiiy No?eenueei?
oeaio?aeueii? ?aeiiii? e?ea?i? Euea?anueei? iaeano?.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? caaa?oaiei
naiino?eiei iaoeiaei aeine?aeaeaiiyi I.I.Iaoouae. Aaoi? iinoaaeea iaoo
oa caaaeaiiy iaoeiai? ?iaioe, i?iaiae?coaaea iaoeiao e?oa?aoo?o ii
aeai?e i?iaeai?, noi?ioaaea ee?i?/i? a?oie iaoe??io?a. Aiae?c oa
?ioa?i?aoaoe?y aeaieo ee?i?/ii-eaai?aoi?iiai, ?ioiieia?/iiai oa
?ino?oiaioaeueiiai ianoaaeaiue cae?eniaia aeena?oaioii. Iniaenoi aaoi?ii
c?iaeaia noaoenoe/ia ia?iaea ?acoeueoao?a, iaienai? an? ?icae?ee
aeena?oaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue oa
iniiai? iieiaeaiiy ?iaioe aena?oeaii a aeiiia?aeyo ia can?aeaii?
eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo (1998), ia can?aeaii? iaeaniiai oiaa?enoaa
aano?iaioa?ieia?a (Euea?a, 1998), 14 c’?cae? oa?aiaao?a Oe?a?ie (1998).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ae?oeiaaieo
i?aoeue o iaoeiaeo aeo?iaeao oa ca??ieeao iaoa??ae?a eiioa?aioe?e,
c?caeo.

Ia?i oa no?oeoo?a ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 142 noi??ieao
iaoeiiieno, neeaaea?oueny c anooio, 4 ?icae?e?a, iaaiai?aiiy iaea?aeaieo
?acoeueoao?a, aeniiae?a, aeiaeaoe?a. ?iaioa ?ethno?iaaia 31
oaaeeoeath, 15 ?enoieaie. Nienie e?oa?aoo?e i?noeoue 205 aeaea?ae.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy.

Aeey ae??oaiiy iinoaaeaieo a ?iaio? caaaeaiue aoei ianoaaeaii 184
iaoe??ioe, c ieo 134 — oai?? AOAeIE, 50 — i?aeoe/ii caei?ia? ethaee.

A?e oai?eo eieeaaany a?ae 17 aei 65 ?ie?a. ?iciiae?e oai?eo AOAeIE
?ethno?o? oaae.1.

Oaaeeoey 1

?iciiae?e oai?eo AOAeIE ca a?eii ? noaooth

A?eO a i ? ? c A O Ae I
E(?ie?a)/ieia?eeae?ieeCaaaeiiaan.%aan.%aan.%17-292619,485,973425,3430-49
4432,842115,676548,5150 ?
noa?oa2417,91118,213526,12Caaaeii9470,15409,85134100,0

sse aeaeii c aeaieo oaae.1 AOAeIE /ano?oa cono??/a?oueny o oai?eo a?eii
a?ae 30 — 49 ?ie?a (48,51%). A?eueo?noue c oai?eo noaiiaeee /ieia?ee —
94 (70,15%). A 61 oai?iai (45,52%) aeyaeaii na?aaei?e nooi?iue aaaeeino?
caoai?thaaiiy. O?eaae?noue ae?aceiai? oai?iae 12-iaei? eeoee eieeaaeany
a?ae 1 oeaeiy aei 25 ?ie?a. Oai?? (95%) iinooiaee a noaoe?iia? a
oa?i?ie, ye? ia ia?aaeuoaaee 10 aei?a a?ae ii/aoeo oai?iae. Na?aae
ianoaaeaieo ia?aaaaeaee iaoe??ioe c o?eaae?noth caoai?thaaiiy aei 1 ?ieo
— 57 (42,54%), iniiaio e?euee?noue yeeo noaiiaeee oai?? c aia?oa
aeyaeaiith AOAeIE. Ae?aaiic anoaiiaethaaany ia i?aenoaa? nea?a,
aiae?c?a, aeaieo ia’?eoeaiiai ianoaaeaiiy. Aiaeineii?/ia aeyaeaiiy
ae?aceiaiai aeaoaeoo aoei iniiaiei ae?aaiinoe/iei e?eoa???i ?aoeeaeeao
ae?aceiai? oai?iae. I?e oeueiio i?eeiaeiny aei oaaae, ui aiaeineii?/ia
aeine?aeaeaiiy aeicaiey? a?eueo aeaoaeueii aea/eoe iai?aaeai?noue
aeeiai?ee ae?aceiaiai i?ioeano, ioe?ieoe noai ??cieo a?aeae?e?a oeoieo
oa aeaaiaaeoeyoeiaei? eeoee, a oaeiae ia?aa??eoe aoaeoeai?noue
i?iaaaeaii? oa?ai??. Noiooi? ae?acoe? ci?ie neeciai? aecia/aee
iae?ineiiiai. Na?aae aeine?aeaeoaaieo in?a ia?aaaaeaee iaoe??ioe c
aaee/eiith ae?aceiaiai aeaoaeoo a iaaeao 0,5–1,0 ni — 75 (55,97%) oa
eieae?caoe??th ae?acee ia ia?aaei?e no?ioe? 92 (68,66%). O a?eueoino?
oai?eo iaea i?noea aeaoi?iaoe?y oeeaoeeie 12-iaei? eeoee, i?e/iio ??
iayai?noue ia aoea iia’ycaia c o?eaae?noth oai?iae. Aeyaeaiiy
Helicobacter pylori (I?) a aano?iaeoiaeaiaeueieo a?iioaoao i?iaiaeeeiny
ca aeiiiiiaith De-Nol oanoo. Ia?aaaaeiei neiioiiii a on?o oai?eo aoa
aieueiaee — 91,79% oa anoaiiaaaaoaoeaiee — 63,43%. I?e ia’?eoeaiiio
ianoaaeaii? a on?o iaoe??io?a a?aei?/aeany iaeueiaoi?ii aieth/?noue a
i?iaeoe?? 12-iaei? eeoee, i?ei?ona, ai?aano?aeuei?e ae?eyioe?.
Aeine?aeaeaiiy oeoieiai? eeneioiino? i?iaiaeeeiny ca aeni?an-iaoiaeeeith
aioo??oiuei-oeoieiai? ?I–iao??? — aacaeueii? oiiia?ao?/ii? ?I–iao??? ii
i?ioyaeiino? oeoieo ca iaoiaeeeith *i?iia?iaiai ? I?aoi?ae (1989) i?e
aeiiiiic? ?iaeeeaoi?a eeneioiino? oeoieo ? ?I–i?e?iciiae?a IA–?I–2
(ae?aiao?ii 2,0 ii).

E??i aeacaieo aeua ianoaaeaiue (caaaeueiiee?i?/ieo oa
eaai?aoi?ii–?ino?oiaioaeueieo), ia 1–2 aeaiue iinooieaiiy oai?eo a
noaoe?iia? aei ii/aoeo e?eoaaiiy ? a ia??iae ianooieaiiy ?ai?n??
i?iaiaeeeiny niaoe?aeueia aeine?aeaeaiiy, iaoith yeiai aoea eiiieaenia
ioe?iea ?ioiieia?/ii? ?aaeoeaiino? o oai?eo AOAeIE. Aeey aea/aiiy
?ioiieia?/ii? ?aaeoeaiino? oai?eo aeei?enoaia iaoiaeeea A. Aaoeiai? (V.
Hashkova, 1978) o iiaeeo?eaoe?? A.A.AEaeoaay (1989, 1991). Ne?ae
aeacaoe, ui an? iieacieee ?ioiiiai noaio ianoaaeoaaieo in?a ii??aithaaee
c aeaieie, iaea?aeaieie i?e ianoaaeaii? caei?iaeo ethaeae — 50. A nai?o
aeine?aeaeaiiyo a?aea?? iaoe??io?a cae?enithaaee aac noiooi?o
caoai?thaaiue c oei, uia aeeeth/eoe aieea inoaii?o ia iieacieee, ui
aea/aeeny.

A caeaaeiino? a?ae i?iaaaeaiiai e?eoaaiiy an? oai?? AOAeIE aoee
iiae?eai? ia 4 a?oie: I a?oia — 51 oai?ee, yeei i?ecia/aeany aacenia
i?ioeae?aceiaa oa?ai?y, yea aeeth/aea ae??oo ? 1, aeieaoi?e i?ioiiiai?
iiiie (iiai?acie ii 20 ia 2 ?ace a aeaiue), aioeoae?eiaaeoa?io oa?ai?th
(o?eoiiie ii 250 ia 4 ?ace a aeaiue aai aii?oeee?i 500 ia 4 ?ace a
aeaiue) oa i?aia?aoe a?niooo (aea-iie ii 120 ia 4 ?ace a aeaiue); II
a?oia — 25 oai?eo AOAeIE, ye? e??i aeua aeacaii? aacenii? oa?ai??
io?eioaaee ianoieeo ao?iaoea? io?io?ii? ii 15 e?aiaeue 3 ?ace a aeaiue
12 aei?a; III a?oia — 35 oai?eo AOAeIE, ye? io?eioaaee aacenio oa?ai?th
a ii?aeiaii? c ianoieeith ao?iaoea? io?io?ii? o aeua aeacai?e aeic? oa
a?oai?iii A (-oieioa?ieii aoeaoaoii) ii 100 ia 1 ?ac a aeaiue i?ioyaii
12 aei?a; IV a?oia — 23 oai?eo AOAeIE, ye? io?eioaaee aacenio oa?ai?th a
ii?aeiaii? c -oieioa?ieii aoeaoaoii o aeua aeacai?e aeic?.

Noaoenoe/ia ia?iaea io?eiaieo aeaieo aeeiiaia ia ia?niiaeueiiio
eiii’thoa?? c aeei?enoaiiyi noaiaea?oieo iaeao?a i?ia?ai Microsoft Word,
6.0.

?acoeueoaoe aeine?aeaeaiue.

Ie i?iaaee ee?i?ei-?ioiieia?/iee aiae?c oai?eo AOAeIE a caeaaeiino? a?ae
oei?a iaaaeii? a?ia?/ooeeaino? (IA*) ii Geels, Coombs, a?eo, o?eaaeino?
oa aaaeeino? caoai?thaaiiy ? aaee/eie ae?aceiaiai aeaoaeoo.

Oaaeeoey 2

?acoeueoaoe ?ioiieia?/ieo aeine?aeaeaiue iaoe??io?a AOAeIE

Oe?E

o.i.O?E

o.i.NNO

o.i.???

o.i.Eiio?ieue

n=5012,50 1,1517,20 1,504,70 0,702,70 0,20AO AeIE

n=13418,92 0,5730,08 0,86

11,18 0,46

1,73 0,07

P0,05), i?ney e?eoaaiiy aeacothoue ia iaaeinoaoith
?ioiieia?/io ei?aeoe?th. Iacaaaeath/e ia oa, ui i?ney e?eoaaiiy Oe?E aoa
iaaeeaeaiee aei ii?ie (N– 12,5±1,15 o.i.), ?aooa iieaciee?a
i?aeoaa?aeaeoaaee iayai?noue ?ioiieia?/iiai aeenaaeaino, yeee ? iaeiei
?c oaeoi??a, ui ni?eythoue i?aeo?eiaiith iaoieia?/iiai i?ioeano a
aano?iaeoiaeaiaeuei?e cii?.

Ioaea, iaaeinoaoiy aoaeoeai?noue caaaeueiii?eeiyoi? oa?iaeioa?ai??
ae?aceiai? oai?iae 12-iaei? eeoee aeeeoo? iaiao?aei?noue aeei?enoaiiy
i?aia?ao?a, ye? aeicaieeee a iie?aueoe iieacieee ?ioiii? nenoaie o
ooieoe?iiaeueiiio ieai? iacaeaaeii a?ae oiai, aoee aiie cieaeai? /e
i?aeaeuai?. A yeino? oaeeo i?aia?ao?a aoei canoiniaaii ianoieeo
ao?iaoea? io?io?ii? oa a?oai?i E.

I?e i?iaaaeaii? aacenii? oa?ai?? a ii?aeiaii? c ianoieeith ao?iaoea?
io?io?ii?, a?aei?/aii ca?eueoaiiy ai?noo a ne?iaaooe? e?ia? Oe?E c
19,16± 0,46 o.i. — 24,24±0,51 o.i. (?

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