IIIINOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo
oai?ia ?i. E.A. A?iiaoaanueeiai

Ie/ee Iaoaey Aiaoie??aia

OAeE: 616.98:579.89-06:616.36-002.14-022:578.891]-085.246.2:546.26

Ee?i?ei-?ioiieia?/i? iniaeeaino? aiaeiaaiii? ?ioieneeaoe?? i?e aaiaoeo?
A ? aoaeoeai?noue aioa?ini?aoe?eii? oa?ai??

14.01.13 – ?ioaeoe?ei? oai?iae

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
iaaee/ieo iaoe

Ee?a –1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai??

?i. ?.ss. Ai?aa/aanueeiai.

Iaoeiaee ea??aiee:

caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe,
i?ioani? I.A. Aiae?ae/ei, Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y
?i. ?.ss. Ai?aa/aanueeiai IIC Oe?a?ie, caa?aeoaa/ eaoaae?e ?ioaeoe?eieo
oai?ia.

Io?oe?ei? iiiiaioe:

— caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, eao?aao Aea?aeaaii? i?ai??
Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? Iiue/ Iao?i Noaiaiiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey IIC Oe?a?ie,
i?ioani? eaoaae?e iaae?ao???;

— caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, eao?aao Aea?aeaaii? i?ai??
Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? A?iiaoaanueea Ethaia
Eaiio??aia, Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa
?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai IIC Oe?a?ie.

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
Aeaieea Aaeeoeueeiai IIC Oe?a?ie, i. Euea?a.

Caoeno a?aeaoaeaoueny “25” eenoiiaaea 1999 ?ieo i 11 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae. 26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i.
E.A. A?iiaoaanueeiai IIC Oe?a?ie ca aae?anith 252015, i. Ee?a, aoe.
N?/iaaiai iianoaiiy, 23.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i.
E.A. A?iiaoaanueeiai IIC Oe?a?ie (252015, i. Ee?a, aoe. N?/iaaiai
iianoaiiy, 23).

Aaoi?aoa?ao ?ic?neaiee “ 25 ” aeiaoiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01
A.Ae. Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Anooi. I?iaeaia a??onieo aaiaoeo?a caeeoa?oueny iaei??th c
iaeaaaeeea?oeo aeey iaoee ? i?aeoe/ii? iaaeeoeeie [Aa?anoi A.A. 1993;
Ao?aeue A.E., 1996; Bowden D.S., 1996; Ni?einii N.I., 1997; Bianchi L.,
1997; Aiae?ae/ei I.A., 1999]. Ca /anoioith o?aaeaiiy ianaeaiiy oe?
oai?iae caeiathoue ae?oaa i?noea i?ney a?eio oa ?ioeo A?A?,
ia?aaaaeath/e ?o o?eaae?noth ? aaaee?noth i?ioeano, noeeuei?noth aei
caoyaeiiai ia?aa?ao oa iani?eyoeeaeo iane?aee?a. Anoaiiaeaii, ui 5 %
ianaeaiiy caiii? eoe? (300-350 iei. in?a) ? iin?yie a??ono aaiaoeoo A
(AA). Eiaeai aeaiue oey oai?iaa caae?a? aeeooy aeae?eueeio oeny/
ethaeae, ye? aie?athoue a?ae oaeeo ?? a?aeaeaeaieo iane?aee?a, ye ?ae ?
oee?ic ia/?iee [Bertoletti A. et al., 1994; Albioushi G.S. et al.,
1997]. Ui?ieo caoai?thaai?noue ia a??oni? aaiaoeoe a Oe?a?i? neeaaea?
170-300 oeny/ aeiaaee?a [Ao?aeue A.E. ? ni?aaao., 1996]. Ana oea
coiiaeth? iaiao?aei?noue iiaeaeueoiai, aeeaoiai aea/aiiy iaoiaaiaco ?
?ic?iaee aoaeoeai?oeo iaoiae?a e?eoaaiiy a??onieo aaiaoeo?a.

Aeooaeuei?noue oaie. Neiae?ii aiaeiaaiii? ?ioieneeaoe?? (A?) ? iaeiei ?c
i?ia?aeieo o iaoiaaiac? aino?eo a??onieo aaiaoeo?a, i?iyae yeiai a
a?eueoino? aeiaaee?a a?aeaeaathoue aaaee?noue ia?aa?ao oai?iae [Oiaineee
I.A. ? ni?aaao., 1979; Ieeieaaaa I.A., Eaaianeay ?.I., 1989; Chiomi S.
et al., 1994]. ?icaeoie aeaiiai neiae?iio iia’ycaiee c oeeoie?cii
ia/?ieiaeo ee?oei, ui coiiaeaiee aeoeaiith ?ai?iaeoeoe??th a??ono
aaiaoeoo A c ianooiiith ?aaeoe??th ?ioiii? nenoaie i?aai?cio [Aa?ooaei
TH.A., Ia?neaeneee TH.A., A?ooiai I.E., 1989; Aa?anoi A., 1993; Pappas
S.C., 1995; Nassal M., Schaller H., 1996]. Iayai?noue /oaei??aeieo
aioeaai?a a o?aaeaieo aaiaoioeeoao ?iaeoue ?o ia’?eoii aoaee
?ioiieiiiaoaioieo ee?oei ? aioeo?e, ai ee?oeie c iiaeeo?eiaaiei
aioeaaiii aieiaiiai eiiieaeno a?noinoi?niino? ?ici?ciathoueny
O-e?ioioeeoaie ye /oae? [Chemelo L., 1986; Jung M.C. et al., 1991].
Aiane?aeie oeueiai ii?ooo?oueny aiiainoac aaiaoioeeo?a ? ianoa? ?o
oeeoie?c [Ionaaaaa A.E., 1988; Na?aaaaa I.A. e ae?., 1992; One/aiei
I.I., Aoaec A.E., 1993], ui oa?aeoa?eco?oueny ooai?aiiyi i?iaeoeo?a
niioai?aiiai iaoaaie?cio, ye? ?iciianthaeaeothoueny ii anueiio
i?aai?cio, ni?e/eiyth/e iioeiaeaeaiiy ??cieo i?aai?a ? oeaiei caeaaeii
a?ae ?o ?acenoaioiino? oa o?iiiino? aei oeo /e ?ioeo iaoaaie?o?a [Iiue/
I.N., 1989]. I?ioean noa? aaia?ae?ciaaiei, ?icaeaa?oueny neiae?ii A? aai
“iaoaaie?/ii? ?ioieneeaoe??” [A?iiaoaanueea E.E., 1997], yeee
oneeaaeith? ia?aa?a iniiaiiai caoai?thaaiiy, ni?e/eiyth/e ??ciiiai?oi?
?iceaaee a ae?yeueiino? nenoai oa i?aai?a, a oaeiae iiaea iaaoaaoe
aaaeeeaiai naiino?eiiai cia/aiiy [Iae N.O., Iaeia A.A., 1992; Ie?iiee
I.A., 1998].

Naia oiio iaeiei c aoaeoeaieo iaoiaeia iaoiaaiaoe/ii? oa?aii? ai?onieo
aaiaoeoia ? aeaciioieneeaoeiy i?aaiicio [Aiceaiiaa AE.E., Ei?/eineee
I.E., Iaoeianeay A.A. e ae?., 1990; Aiae A.Ae., A?iiaoaanueea E.E.,
Oaoueyiei I.A. oa ?i., 1993; Iaeue A.I., Iieoe/e A.E., 1996]. Iae/anoioa
c oei?th iaoith canoiniaothoue iiooci? ?ic/eiia aetheice /e
iecueeiiieaeoey?ieo aeaeno?aiia [Aiae?ae/ei I.A., 1998]. Ua aeiiaaeaaia
i?ecia/aee i?aia?aoe iieiaiiiei??ie?aeiio, aea o ca’yceo c aeyaeaieie
iia?/ieie aieeaaie ?o ia?aioa?aeueia aeei?enoaiiy caai?iiaia [Aic?aiiaa
AE.?., Aianoan?e ?.A., 1997]. I?inoei o aeeiiaiii, iaiiaaceaiei ? iaoiae
aioa?ini?aoei?, a iniia? yeiai eaaeeoue aeniea aai?ia caeaoiinoue ?yaeo
ni?aoeieieo ?a/iaei [O?ieia A.O., Oa?thiia A.E., Aiae A.Ae. e ae?.,
1988; Aiae?ae/ei I.A., Aaaao A.A., Aiaothe I.N. e ae?., 1991; Cabre E.,
Gassull M.A., 1994].

Iaeiae aeei?enoaiiy aioa?ini?aaio?a c o?aooaaiiyi on?o iaoai?ci?a ?o
ae?? ia i?aaiici, o ia?oo /a?ao ia iioiio oa aioeieneaeaioio nenoaie,
iiee ui ia aaieoei o oe?ieo eeiii/io i?aeoeeo, a i?aeoe/i?e iaaeeoeeii
aiaenooiie /ioeee eaai?aoi?iee eiio?ieue ?o aoaeoeaiinoi. Oea
i?eaiaeeoue aai aei iaaeinoaoiueiai i/euaiiy i?aaiicio, ui ?iaeoue
iaaoaeoeaieie i?iaaaeaii aeaoieneeaoe?ei? caoiaee, aai, iaaiaee, aei
?ioaineaiiai aeaaaeaiiy ?acii c oiene/ieie i?iaeoeoaie ei?enieo ?a/iaei,
ui iaaacia/ii ? iiaea i?ecaanoe aei ii?ooaiiy iiiiiai aaeaino oa iioeo
iani?eyoeeaeo cnoaia [Aieeeia N.I., Naiioeeee E.A., I?oiia E.E., 1986].
Ia’?eoeai? e?eoa??? aea?aaeaioiino? aeaoieneeaoe?eii? oa?ai?? ia
nueiaiaei? aeinoaoiuei ia aecia/ai? ? oiio ia aeei?enoiaothoueny.

Iaoa ?iaioe: aeyaeoe ee?i?ei-iaoiaaiaoe/i? iniaeeaino? A? o oai?eo ia
aino?ee AA c ??ciei nooiaiai aaaeeino? ia?aa?ao, aieea aiaeioienai?? oa
aiaeioieneeico ia noai ?ioiii? nenoaie i?aai?cio oa iiaeeea?noue eiai
cieaeaiiy ca aeiiiiiaith aioa?ini?aaioo.

Iniiai? caaaeaiiy ?iaioe.

1. Aeine?aeeoe ??aaiue aiaeioienai?? oa aiaeioieneeico o oai?eo ia
aino?ee AA o ??ci? ia??iaee oai?iae.

2. Ia i?aenoaa? aeine?aeaeaiiy A? ?ic?iaeoe ia’?eoeai? e?eoa???
aaaeeino? ia?aa?ao AA ? iiaeeeaiai i?iaiicoaaiiy aino?iai aaiaoiiae?ico.

3. Aea/eoe ci?ie ?ioiii? nenoaie oai?iai i?aai?cio caeaaeii a?ae ??aiy
A?.

4. Aeine?aeeoe ee?i?/io aoaeoeai?noue canoinoaaiiy iie?-ea?aey a
eiiieaeniiio e?eoaaii? oai?eo ia AA ??cii? aaaeeino?.

5. Anoaiiaeoe aieea aioa?ini?aoe?eii? oa?ai?? ia ??aaiue A?,
aioeieneaeaioiee caoeno oa ?ioiiee noaoon i?aai?cio i?e AA.

6. Aea/eoe noai aioeieneaeaioii? nenoaie ia/?iee oa ieacie e?ia? o
oaa?ei c aenia?eiaioaeueiei oiene/iei aaiaoeoii, e?eiaaieo iie?-ea?aey.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa ? o?aaiaioii ieaiiai? iaoeiai? ?iaioe eaoaae?e ?ioaeoe?eieo
oai?ia Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss.
Ai?aa/aanueeiai “Oaeineiiaeaiiy e?eoaaiiy oai?eo ia aino?? eeoeia?
?ioaeoe?? ??cii? ao?ieia??” (Aea?ae?a?no?aoe?eiee iiia?
16E-980196V023275).

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. O aeena?oaoe?? nenoaiaoeciaai?
oa ia i?aenoaa? ee?i?ei-eaai?aoi?ieo aeaieo (iieacieee ooieoe?iiaeueiiai
noaio ia/?iee oa A?) iaa?oioiaai? iia? aeiaeaoeia? ia’?eoeai? e?eoa???
ioe?iee aaaeeino? ia?aa?ao AA.

Cai?iiiiiaaii iia? iaoiaee/i? i?aeoiaee aei ioe?iee A? o oai?eo ia AA,
ye? a?aoiaothoue ??aaiue aiaeioienai?? oa aiaeioieneeico. Aia?oa aeaia
ee?i?ei-iaoiaaiaoe/ia ioe?iea aiaeioienai?? oa aiaeioieneeico o
c?noaaeaii?. Aia?oa o aeeiai?oe? AA aeine?aeaeaii ai?no aiaeioienei?a a
?ioa?noeoe?eiiio i?inoi?? oa ?o ?ieue o iaoiaaiac? e ee?i?/iiio ia?aa?ao
oai?iae.

O ??ci? ia??iaee aino?iai AA anoaiiaeaii aieea ??aiy A? ia ?ioiiee
noaoon oai?iai i?aai?cio.

?yae noi?ioeueiaaieo o ?iaio? eiioeaioe?e iiaea ?icoe?ithaaoeny ye
aeiaeaoeiaa oai?aoe/ia iniiaa aeey iiaoaeiae aeeoa?aioe?eiaaieo
e?eoaaeueieo i?ia?ai.

Aia?oa aeine?aeaeaii aieea iiaiai aioa?ini?aaioo iie?-ea?aey ia
ee?i?/iee ia?aa?a AA, iniaeeaino? eiai aeaoieneeaoe?eii?,
?ioiiiiaeoethth/i? oa aioeieneaeaioii? ae??. A aenia?eiaio? ia oaa?eiao
c oao?aoei?iaoaiiaei aaiaoeoii, e?eiaaieo iie?-ea?aey, anoaiiaeaii
i?aeaeuaiiy aeoeaiino? oa?iaioaoeaii? aioeieneaeaioii? nenoaie (AIN)
ia/?iee oa ieacie e?ia?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? ia’?eoeai?
e?eoa??? ??aiy A? i?aai?cio o oai?eo ia AA, ye? aeicaieythoue ioe?ieoe
nooi?iue aaaeeino? oai?iae ? ni?iaiicoaaoe eiia??i?noue iiaeaeueoiai
?icaeoeo aaiaoiiae?ico. ?aeiiaiaeiaaii aeei?enoiaoaaoe iieacieee A? aeey
ioe?iee aoaeoeaiino? aeaoieneeaoe?eii? oa?ai??. I?inoioa oa
?ioi?iaoeai?noue cai?iiiiiaaii? ae?aaiinoe/ii? i?ia?aie ?iaeyoue ??
i?eaeaoiith aeey oe?ieiai i?aeoe/iiai canoinoaaiiy.

Aeaeai?, ocaiaeaeai? c IIC Oe?a?ie, iaoiaee/i? ?aeiiaiaeaoe?? “Iaoiaee
aeine?aeaeaiiy aiaeiaaiii? ?ioieneeaoe?? i?aai?cio” (ni?aaaoi?e
Aiae?ae/ei I.A., Aao I.Ae., Aeai’yiaiei A.A., Ie/ee A.C.), ye? ?ic?neai?
ia aae?ane i?io?eueieo e?eoaaeueieo caeeaae?a on?o iaeanoae ? i?ia?aeieo
oao?aoe?a.

Iaa?oioiaaia aeioe?euei?noue aeei?enoaiiy aioa?ini?aaioo iie?-ea?aey c
iaoith ciaioaiiy ?iceaae?a iaoaaie?cio, iiina?aaeeiaaii? ei?aeoe??
?ioiii? a?aeiia?ae? oa aioeieneaeaioii? aeoeaiino? i?aai?cio oai?eo ia
AA. Iieacaii, ui canoinoaaiiy iie?-ea?aey a eiiieaeniiio e?eoaaii?
i?enei?th? iaeoaeaiiy in?a ?c na?aaeiueiaaaeeei ia?aa?aii aaiaoeoo oa
ni?ey? ciaioaiith ?iceaae?a aiiainoaco i?e aaaeeiio ia?aa?ao.
?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeaii a
e?eoaaeueii-ae?aaiinoe/io i?aeoeeo ?ioaeoe?eieo noaoe?iia??a
Oa?iii?euenueei? oa ??aiainueei? iaeanoae, a oaeiae o iaa/aeueiee
i?ioean ia eaoaae?? ?ioaeoe?eieo oai?ia Oa?iii?euenueei? aea?aeaaii?
iaaee/ii? aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiai.

Iniaenoee aianie caeiaoaa/a. An? aoaie aeine?aeaeaiiy aaoi? cae?enieea
naiino?eii, aeeth/ath/e ieaioaaiiy, i?iaaaeaiiy ee?i?/ieo niinoa?aaeaiue
oa aenia?eiaioaeueieo aeine?aeaeaiue, iae?e oa aiae?c io?eiaieo
?acoeueoao?a, noaoenoe/io ia?iaeo oeeo?iaeo aeaieo, ?ic?iaeo iniiaieo
iieiaeaiue oa aeniiae?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue, ui
aeeth/ai? aei aeena?oaoe??, ii?eethaeiaii ia i?aeia?iaei?e eiioa?aioe??
“Aeooaeuei? ieoaiiy ii?oieia??” (Oa?iii?eue, 1996), ia XIII c’?cae?
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a ?
ia?aceoieia?a ?i. Ae.E. Caaieioiiai (A?iieoey, 1996) oa ia I e II
I?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo
(Oa?iii?eue, 1997, 1998), 5-io c?cae? ?ioaeoe?ii?no?a Oe?a?ie
(Oa?iii?eue, 1998), ia can?aeaiiyo iaeaniiai iaoeiai-iaaee/iiai
oiaa?enoaa ?ioaeoe?ii?no?a, ui??/ieo i?aenoieiaeo iaoeiaeo eiioa?aioe?yo
iaaeaeaaeai?? (1997, 1999).

Ioae?eaoe??. Iniiai? ?acoeueoaoe ?iaioe iioae?eiaai? a iaoeiaeo
aeo?iaeao 3 noaoo?, o iaoa??aeao iaoeiaeo eiioa?aioe?e 15.

No?oeoo?a ? ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny c anooio, 7
?icae?e?a, aeniiae?a oa nieneo aeei?enoaii? e?oa?aoo?e, yeee aeeth/a?
370 aeaea?ae. Aeeeaaeaia ia 194 noi??ieao eiii’thoa?iiai oaenoo, c ieo
148 noi??iie caeiathoue oaenoia? iia?aeiieaiiy, 5 ?ethno?aoe??, 42
noi??iee nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae. ?iaioa aeeth/a? 24
oaaeeoe?, 14 ?enoie?a, 9 aeoya?a c ?noi??e oai?ia.

INIIAIEE CI?NO ?IAIOE

?icae?e ia?oee “Neiae?ii aiaeiaaiii? ?ioieneeaoe?? a iaoiaaiac? oa
ee?i?oe? ?ioaeoe?eieo oai?ia ? oeyoe eiai iiaeieaiiy” i?enay/aiee
oai?aoe/iiio aiae?co e?oa?aoo?e ia oaio aeena?oaoe??.

Anoaiiaeaii, ui iaei??th c i?ia?aeieo eaiie iaoiaaiaco ?ioaeoe?eieo
oai?ia ? neiae?ii A?, i?iyae yeiai o a?eueoino? aeiaaee?a aecia/a?
aaaee?noue ? aene?ae caoai?thaaiiy. Oiene/i? iaoaaie?oe iaaaoeaii
aieeaathoue ia an? nenoaie oa i?aaie oai?iai i?aai?cio, ni?e/eiyth/e ?o
ii?oieia?/i? ? ooieoe?iiaeuei? ii?ooaiiy. Ioneiaei iaoai?ciii A? i?e
aino?iio AA ? oeeoie?c ia/?ieiaeo ee?oei, coiiaeaiee ?ai?iaeoeoe??th
a??ono c ianooiiith ?aaeoe??th ?ioiii? nenoaie. Neiae?ii A? i?e aino?eo
a??onieo aaiaoeoao noi?iaiaeaeo?oueny iineeaiiyi i?ioean?a ia?aeeniiai
ieeneaiiy e?i?ae?a, ii?ooaiiyie a ae?yeueiino? aioeieneaeaioii? oa
?ioiii? nenoai, iioeiaeaeaiiyi ee?oei e?ia?, o?aaeaiiyi ia?aiai?
nenoaie.

Aoaeoeaiei ? aacia/iei iaoiaeii aeaaaeaiiy oiene/ieo iaoaaie?o?a c
i?aai?cio ? aioa?ini?aoe?y. Aioa?ini?aaioe caiia?aathoue iioeiaeaeoth/?e
ae?? oienei?a, i?iaeoeo?a a?eueii-?aaeeeaeueiiai ia?aeeniiai ieeneaiiy
e?i?ae?a, ii?iae?cothoue ?ioii?acenoaioi?noue i?aai?cio, noeioeththoue
iioi?io ooieoe?th eeoe?aieea, ni?eythoue cieaeaiith o e?ia? ai?noo
caaaeueiiai a?e??oa?io, aeoeaiino? ne?iaaoeiaeo ai?iio?ainoa?ac, oei
naiei coiiaethth/e oaeaeoa iaeoaeaiiy oai?eo.

I?ioa, i?e i?iaaaeaii? aeaoieneeaoe?eii? oa?ai?? iaeaea ia
canoiniaothoueny ia’?eoeai? iaoiaee aeine?aeaeaiiy ?? aoaeoeaiino?, ui
ia aeicaiey? ioe?ieoe nooi?iue aeo?aeii? aeaoieneeaoe?eii? ni?iiiaeiino?
i?aai?cio oa aaeaeaaoi?noue canoiniaaieo cania?a uiaei iayaieo a iueiio
oienei?a. O naith /a?ao, caiaaeoi ?ioaineaia aeaoieneeaoe?eia oa?ai?y
aac a?aeiia?aeiiai eiio?ieth iiaea caaaeaoe oeiaee oai?iio.

?icae?e ae?oaee “Iaoa??aee ? iaoiaee i?iaaaeaieo aeine?aeaeaiue”
i?enay/aiee iieno iaoiae?a oa i?aai?caoe?? aeena?oaoe?eiiai
aeine?aeaeaiiy. Aeeth/a? i?ae?icae?ee “Iaoiaee aeine?aeaeaiiy
aiaeiaaiii? ?ioieneeaoe?? i?aai?cio”, “Iaoiaee aeine?aeaeaiiy ?ioiii?
nenoaie”, “Iaoiaee aeine?aeaeaiiy aioeieneaeaioii? nenoaie”, “A?aea??
oaa?ei aeey aeine?aeaeaiiy”, “Caaaeueiii?eeiyo? aeine?aeaeaiiy
aaiaoia?e?a?ii? nenoaie oa noaoenoe/ia ia?iaea oeeo?iaiai iaoa??aeo”,
“Ei?ioea ee?i?/ia oa?aeoa?enoeea ianoaaeaieo oai?eo”.

Aeey ioe?iee ??aiy aiaeioienaii? aecia/aee oiene/i?noue e?ia? (OE) ca
nia?iaoici?aeiei oanoii (NO) [A?aoiye A.A., Aao I.Ae., ?iiaithe A.I.,
1993] oa eiioeaio?aoe?th iieaeoe na?aaeiuei? iane (INI) [Aaa?eyeyi I.E.,
Eeiaoiaa A.E., 1984] o iiaeeo?eaoe?? Ae.E. A?anthea (1995), e?eoa???ie
aiaeioieneeico neoaeeee noia?ia oiene/i?noue e?ia? oa ?ioa?noeoe?eii?
??aeeie (NOE??) [Aao I.Ae., 1992] oa aioeoiene/ia ?acenoaioi?noue ee?oei
e?ia? (A?EE) [Aao I.Ae., Aeai’yiaiei A.A., Aanenothe ?.?., 1993].

?ioiiee noaoon ioe?ithaaee ca iieacieeaie ee?oeiii? oa aoii?aeueii?
eaiie. C iaoith iiaeeeaoei? O- i A-eiioioeeoia canoiniaoaaee iaoiae
eiiaiiiaaiiai ?icaoeiooai?aiiy ca Mendes N.F. ? ni?aaao. (1974) o
iiaeeo?eaoe?? A.O. O?ieiaa oa ?.N. Ia?eiaa (1984). Noaiiioeyoeith
aeoeaieo O-eiioioeeoia (Aaeo-?OE) iiae?aoiaoaaee ca aeiiiiiaith iaoiaeo
Smith R. ? ni?aaao. (1975). Eieuee?noue oaioieiii?acenoaioieo i
oaioieiii/ooeeaeo A-?OE o ia?eoa?e/iie e?iai aecia/aee ca iaoiaeii
Limatibul S. et al. (1978). Ae?aoiaoaaee oaioieiiiaee eiaoioei?io
(niiaaiaeiioaiiy oaioieiii?acenoaioieo i oaioieiii/ooeeaeo A-?OE) oa
eiaoioei?io iioiinoeioethth/i? aei? (E?Ae) i?aia?aoo ca iaoiaeii
Aiae?ae/eia I.A., ?uoe ?.N., Ainiiaea?nueeiai ?.ss. (1995).
Eiioeaio?aoeith ne?iaaoeiaeo iioiiaeiaoeiiia eeania A, I i G aecia/aee
aiioiii/iei iaoiaeii ca Badin, Ronsellet o iiaeeoieaoei? Ea?nueeiai A.A.
i E?aa/aiei I.I. (1971). ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a
(Oe?E) aeine?aeaeoaaee iaoiaeii i?aoeei?oaoe?? a 10 % ?ic/ei?
iie?aoeeaiae?eiey c iieaeoey?iith ianith 6 EAe [Ianyii?eiaa I.A., 1994].
Ai?no ne?iaaoeiaiai e?cioeeio aecia/aee ca aeiiiiiaith aoeaoiiiaiai
ii?ioeo Micrococcus lysodeicticus [A?aio O. ss. oa ni?aaao., 1973].

sseiniee ? eieueeiniee aiaeic aiinoo aioeaai?a a??ono aaiaoeoo A
i?iaiaeeany iioiioa?iaioiei aiaeicaoi?ii AEO-Oe-01N aaoiiaoe/ii ca
niiaaiaeiioaiiyi aenoeieoei? eiio?ieueieo i aeineiaeaeoaaieo c?aceia
ne?iaaoee e?iai.

Aeoeai?noue eaoaeace aecia/aee ca iaoiaeii Ei?iethea I.A. ? ni?aaao.
(1988), aeooao?iiia?ieneaeace ca iaoiaeii E?oaeeeiaa A.I., Ooooiai ?.I.
(1976), aeooao?ii?aaeoeoace ca e?euee?noth IAAeOI, ui aeo?a/a?oueny o
oa?iaioaoeai?e ?aaeoe?? a?aeiiaeaiiy ieeneaiiai aeooao?iio [Ei?iethe
I.A. ? ni?aaao., 1988]. Ai?no oea?oeiieaci?io a ieaci? e?ia? aecia/aee
ca iaoiaeii, i?eioeei yeiai aaco?oueny ia caeaoiino? n-oai?eaiae?ai?io
ieenethaaoeny a i?enooiino? oea?oeiieaci?io c ooai?aiiyi caaa?aeaieo
i?iaeoeo?a [Eiea A.A., Eaiuoieeia B.C., 1982].

Aeey aeeiiaiiy iinoaaeaieo caaaeaiue ia aaci eeiii/ii? eiea?ii ? 1 iinoa
Oa?iiiiey ianoaaeaii 126 oai?eo ia AA. A?oio ii?iaiyiiy neeaee 22
caei?ia? iniae. Oai?eo ianoaaeoaaee a oaei oa?iiie:

1) o ?iciae aeiaoyie/iiai ia?iiaeo oai?iae, iaeneiaeueiiai ae?aaeaiiy
?? eeiii/ieo i aiioiii/ieo i?iyaia, ia?aae i?ecia/aiiyi a?aeiia?aeiiai
eo?no eieoaaiiy;

2) o noaae?? niaaeo aeiaoyieoe?, iiney ai?iaiaaiiai eo?no eieoaaiiy;

3) o noaae?? ?aiiuei? ?aeiiaaeanoeaioei? (ia?aae aeienoaaiiyi).

Iaoe??ioe aoee aieii aiae 16 aei 72 ?ieia. I?e aeeoa?aioeithaaiii
aoiieiai/ieo aeaeia aaiaoeoo aeei?enoiaoaaee aeaii aiiaeaiiieiai/ieo,
eeiiiei-eaai?aoi?ieo oa na?ieiai/ieo ianoaaeaiue. Iiaeoaa?aeaeaiiyi
aeiaaiico AA aoei aeyaeaiiy a ne?iaaooei e?iai IAsAg oa IAaAg oa
a?aenooi?noue aioe-HCV.

Aeoiaey/e c iaoe i caaaeaiue aeineiaeaeaiue, iiaeae?aeeny oai?i c
eaaeei, na?aaeiueiaaaeeei e aaaeeei ia?aaiaii caoai?thaaiiy ca?aeii c
iaoiaeii ?aiaeii?caoe??.

Eaaea oi?ia aaiaoeoo aoea o 19 oai?eo (15,1 %), na?aaeiueiaaaeea o 51
(40,5 %), aaaeea o 47 (37,3 %), aeoaea aaaeea – o 9 (7,1 %).

A?aeiia?aeii aei iaoe aeine?aeaeaiiy ianoaaeoaaeeny oai?? aac aaaeeeo
noiooi?o caoai?thaaiue.

O ?iciae caoai?thaaiiy o aieueoinoi oai?eo aeiiiioaaee iciaee neiae?iio
iioieneeaoei?. Cia/io /anoeio oai?eo (39,2 %) oo?aoaaea ioaeioa.
Nooinoue ? ai?eioo a ?ioi aiaecia/aee 18,3 % oai?eo, cae?aie 25,6 %,
ii?ooaiiy nio 17,1 %, ae?aoeeainoue 14,6 %. Aethaaiiy, aeenoaaiy,
ia/iy, i?iiin oo?aoaaee eeoa 8 inia.

Anoaiiaeaii, ui neiae?iie iioieneeaoei? oa o?aaeaiiy o?aaii? nenoaie
aoee i?ia?aeieie na?aae eeiii/ieo i?iya?a ye ii/aoeiaiai ia?iiaeo, oae i
ia??iaeo ?iciaeo AA.

Eiioeaio?aoeiy aiei?oaiio e?iai, ca aeiyoeii oieanoaoe/iiai aa?iaioo
aaiaoeoo, a iniiaiiio aiaeiiaiaeaea aaaeeinoi oai?iae. I?e eaaeiio
ia?aa?ao aiia noaiiaeea 69,523,98 ieiieue/e, na?aaeiueiaaaeeiio
151,929,21 ieiieue/e, aaaeeiio 294,6323,72 ieiieue/e, ca ai?noii
ia?aaaaeaea ca’ycaia o?aeoeiy iiaiaioo.

O anio oai?eo aeyaeaii iiaeaeuaio aeoeaiinoue aeaiii- oa
ania?oaoaiiiio?ainoa?ace, aeniei iieacieee oeiieiai? i?iae e?ia?.

Oaeei /eiii, niinoa??aaee oai?eo c oeiiaei ia?aaiaii aeiaoyie/ii? oi?ie
AA.

Aenia?eiaioaeueio /anoeio aeine?aeaeaiiy i?iaiaeeee ia 48 a?eeo
aacii?iaeieo uo?ao-naioeyo. Aeey aenia?eiaioo aoei ae??oaii aeei?enoaoe
iiaeaeue oao?aoei?iaoaiiaiai oiene/iiai aaiaoeoo, ui aeicaieeei
ni?e/eieoe o?aaeaiiy ia/?ieiaeo ee?oei, iiae?ai? aei ci?i i?e a??oniiio
aaiaoeo?. Oiene/iee aaiaoeo iiaeaethaaee oeyoii i?aeoe??iiai aaaaeaiiy
50 % ianeyiiai ?ic/eio /ioe?eoei?enoiai aoaeaoeth (CCl4) a aeic? 2 a/ea
i?ioyaii 4-o aei?a.

An? i?aeaeine?aei? oaa?eie aoee ?icae?eai? ia oae? a?oie:

1) ?ioaeoi?; 2) eiio?ieuei? (i?ney aaaaeaiiy ?ic/eio CCl4); 3) oaa?eie
i?ney aaaaeaiiy CCl4, ye? iaea?aeoaaee uiaeaiii aioa?aeueii ni?aaio
iie?-ea?aey a aeic? 0,5 a/ea (aeica ni?aaioo i?ae?a?aia ca?aeii c
aeaieie e?oa?aoo?e).

Oaa?ei aeaeai?ooaaee ia 4-oo, 7-io ? 12-oo aeiao a?ae ii/aoeo aaaaeaiiy
oao?aoei?iaoaio. Aeine?aeaeoaaee ieacio e?ia? ? oeaieio ia/?iee.

An? aenia?eiaioe ia oaa?eiao i?iaiaeeee ca?aeii aei “I?aaee aeei?enoaiiy
eaai?aoi?ieo aenia?eiaioaeueieo oaa?ei”, 1984, aeiaeaoie 4.

Io?eiaii a i?ioean? aeine?aeaeaiiy aeaii ia?iaeaii iaoiaeii aa?iaoeieii?
noaoenoeee oeyoii ia/eneaiiy na?aaeiuei? a?eoiaoe/ii? (I) i ??
na?aaeiuei? iioeaee (m) c a?aooaaiiyi /enea niinoa?aaeaiue. Ioeiiea
aeinoiai?iinoi cae?enithaaeany ca aeiiiiiaith e?eoa?iy Nouethaeaioa ca
iieacieeii ?. ??aaiue iaoi/iino? oa ??aaiue eiia??iino? iathoue
a?a?o?a?iee oa?aeoa?, oiio aecia/eee aeia??/? iaae? aeey ??aiy
iaoi/iino? 5 % ? ??aiy eiia??iino? ia iaioa 95 %. C iaoith aeyaeaiiy
iiaeeeai? caeaaeiinoi iiae io?eiaieie iieacieeaie aecia/aee eiaoioei?io
ei?aeyoei? (r). Noaoenoe/ia ia?iaea oeeo?iaiai iaoa?iaeo aeeiioaaeany ca
aeiiiiiaith i?eeeaaeieo i?ia?ai iaoaiaoe/ieo aeaeo?iiieo oaaeeoeue c
aeei?enoaiiyi eiii’thoa?a.

?icae?e o?ao?e “Neiae?ii aiaeiaaiii? ?ioieneeaoe?? o oai?eo ia AA”
aeeth/a? ?ioi?iaoe?th i?i ci?ie ee?i?ei-eaai?aoi?ieo iieaciee?a A? o
?iciae aeiaoyie/iiai ia??iaeo AA, ia niaae? aeiaoyieoe? oa a ?aii?e
?aeiiaaeanoeaioe??, ??aaiue A? o oai?eo ?c caa?icith aaiaoiiae?ico.

Ca ii?io A? aoee i?eeiyo? ?acoeueoaoe aeine?aeaeaiue a?oie caei?iaeo
ethaeae (22) ??ciiai a?eo. OE ca nia?iaoici?aeiei oanoii o ieo noaiiaeea
0,200,10 %, ai?no INI280 o ne?iaaooe? e?ia? 0,240,01 oi.iae, INI254
0,480,02 oi.iae., NOE?? 0,300,15 %, A?A 0,930,07 oi.iae., A?E
0,0900,010.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ??aiy A? i?aai?cio i?e AA c
??ciei nooiaiai aaaeeino? ? ianooiiiai c?noaaeaiiy io?eiaieo aeaieo ?c
caaaeueiii?eeiyoeie ee?i?ei-eaai?aoi?ieie iieacieeaie ?ic?iaeaii
ia’?eoeai? e?eoa??? aecia/aiiy aaaeeino? ia?aa?ao oai?iae, ye?
aeiiiaiththoue ?ai?oa a?aeii? iciaee.

Aeyaeaii, ui i?e eaaeiio ia?aa?ao aaiaoeoo ?ioieneeaoe?eiee neiae?ii
coiiaeaiee aiaeioieneiaie, ye? ia?aaoaathoue o e?iaiiiniiio ?one?, oiaoi
??aiai aiaeioienai??. Aiaeioieneeic, ye oaeee, ia cia/iee ? nooo?aiai
aieeao ia ee?i?/iee ia?aa?a oai?iae ia coiiaeth?. I?e na?aaeiueiaaaeeiio
ia?aa?ao aaiaoeoo c?inoa? ??aaiue aiaeioienai?? oa aiaeioieneeico, ui
i?ecaiaeeoue aei cia/i?oeo noa’?eoeaieo i?iya?a ?ioieneeaoe?? oa
noi?iaiaeaeo?oueny ia?inoaiiyi ooieoe?iiaeueieo ?iceaae?a ia/?iee.

Ca?eueoaiiy oiene/ieo i?iaeoeo?a iica iaaeaie e?iaiiiniiai ?onea, yea
i?inoaaeo?oueny i?e aaaeeiio ia?aa?ao aaiaoeoo, i?ecaiaeeoue aei
nooo?aeo ii?ooaiue ae?yeueiino? i?aai?a ? nenoai, ine?eueee oieneie
ia?aaoaathoue o aaciina?aaeiueiio eiioaeo? c a?iiaia?aiaie ee?oei.
C?iaeoe oaeee aeniiaie aeicaieeee ?acoeueoaoe aeine?aeaeaiue NOE?? oa
A?EE, ye? aeyaeeeny oe?ii?oeie aeey aecia/aiiy nooiaiy aaaeeino?
oai?iae, ine?eueee iaea?eueo ia’?eoeaii a?aeia?aaeathoue ?iceaaee
ae?yeueiino? i?aai?cio, ni?e/eiai? ae??th oienei?a. Anoaiiaeaii oaeiae,
ui oaeaeea ia?inoaiiy eiioeaio?aoe?? oienei?a a ?ioa?noeoe??, yea
ia?aaeuo? ?o ??aaiue, oa?aeoa?iee aeey aaaeeiai ia?aa?ao aaiaoeoo, oa
?ioaineaia cieaeaiiy A?EE aeacothoue ia iiaeeeaee ?icaeoie ianeaiiai
aaiaoiiae?ico. Oiio i?e aeyaeaii? ??aiy NOE??, a?eueoiai i?ae 9,5 %,
aioeoiene/ii? ?acenoaioiino? a?eo?ioeeo?a (A?A), iaioi? a?ae 0,5 oi.
iae., oa aioeoiene/ii? ?acenoaioiino? eaeeioeeo?a (A?E), iaioi? a?ae
0,06, aa?oi ?icii/eiaoe ?ioaineaio oa?ai?th, ni?yiiaaio ia caiia?aaiiy
?icaeoeo ia/?ieiai? eiie.

O /aoaa?oiio ?icae?e? “Aieea aiaeiaaiii? ?ioieneeaoe?? ia ?ioiiee
noaoon i?aai?cio i?e AA” iaaaaeaii aeai? i?i iieacieee ?ioiii? nenoaie
caeaaeii a?ae ??aiy A? o ?iciae aeiaoyie/iiai ia??iaeo AA, ia niaae?
aeiaoyieoe? oa o ?aii?e ?aeiiaaeanoeaioe??, ci?ie ?ioiiiai aiiainoaco o
oai?eo ?c caa?icith aaiaoiiae?ico.

Ia i?aenoaa? ?acoeueoao?a ia?aeaeueiiai aeine?aeaeaiiy A? oa ?ioiiiai
aiiainoaco i?aai?cio c?iaeaii aeniiaie i?i aca?iicaeaaei?noue aeyaeaieo
ci?i. I?e eaaeiio ia?aa?ao aaiaoeoo ia oe? iaaaeeei? e?eueeino?
oiene/ieo i?iaeoeo?a a i?aai?ci?, aeaui cieaeaii? A?EE ?ioiia nenoaia ia
ii?ooaiiy caaaeueiiai aiiainoaco, ?iaeoeiaai? iayai?noth a??ono,
?aaaoaaea aaeaeaaoii. O noaae?? ?aiiuei? ?aeiiaaeanoeaioe?? iieacieee A?
oa ?ioiii? ?aaeoeaiino? i?aai?cio a?aeiia?aeaee oaeei o caei?iaeo
ethaeae.

O oai?eo ?c na?aaeiueiaaaeeei ia?aa?aii aaiaoeoo aeyaeaii a?eueo? ci?ie
?ioiiiai aiiainoaco, ye? noi?iaiaeaeoaaeeny iaa?iiaaeaeaiiyi oienei?a ye
o e?iaiiiniiio ?one?, oae ? a ?ioa?noeoe?eiiio i?inoi??. O ia??iae
iie?auaiiy ee?i?ei-a?io?i?/ieo iieaciee?a ii?yae c aeoeaiith
ae?i?iaoe??th oienei?a c i?aai?cio a?aeaoaaeeny iiceoeai? ci?ie o
ooieoe?iioaaii? ?ioiii? nenoaie.

O oai?eo c aaaeeei ia?aa?aii aaiaoeoo aeyaeyee noai aoi?eiiiai
?ioiiaeao?oeeoo c iaaeinoaoi?noth an?o eaiie ?ioiii? a?aeiia?ae?
(ee?oeiii?, aoii?aeueii?, ianiaoeeo?/ii? ?acenoaioiino?). Ca?eueooaaeany
O-e?ioiiai?y i?inoaaeoaaeiny iine?aeiaia cieaeaiiy ai?noo O-oaeia??a ?
O-noi?ani??a, oaio?e?iiaee eiao?oe??io c?inoaa aei 4,570,21. Ii??aiyii c
na?aaeiueiaaaeeei ia?aa?aii aeinoia??ii ca?eueooaaeany e?euee?noue
0-ee?oei ? niinoa??aaeany oaiaeaioe?y aei iiaeaeueoiai c?inoaiiy
«iaiiaieo» e?ioioeeo?a, ui iaaiith i??ith na?ae/eei i?i aeniaaeaiiy
eiiiainaoi?ieo iiaeeeainoae ?ioiii? nenoaie. Eiioeaio?aoe?y Ig A
ca?eueooaaeany ia 44,5 %, Ig M ia 133,0 %, Ig G ia 34,5 % (?<0,05 o an?o aeiaaeeao). Ai?no Oe?E aoa aeoaea aenieei 310,1023,30 iae (?<0,05). Iieacieee A? ia oeae ia??iae na?ae/eee i?i noai oyaeeiai aiaeioieneeico. Ia niaae? aeiaoyieoe? aeyaeai? ii?ooaiiy ?ioiii? nenoaie iinooiiai ciaiooaaeeny, a?aeiia?aeii cieaeoaaany aeya aiaeioieneeico, oi/a ??aaiue aiaeioienai?? ana ua aoa aeineoue aenieei. O?eaae?noue iaeoaeaiiy iaaaaaoi ia?aaeuoaaea oaeo i?e eaaeiio oa na?aaeiueiaaaeeiio ia?aa?ao aaiaoeoo. Ia?aae aeienoaaiiyi o oai?eo c aaaeeei aaiaoeoii ?ioiieia?/i? iieacieee aei ii?ie ia i?eoiaeeee, aeine?aeaeaiiy A? aeacoaaee ia i?aeaeuaiee ai?no oienei?a o e?iaiiiniiio ?one? oa ?ioa?noeoe??. ?icae?e i’yoee “E?eoaaeueia aoaeoeai?noue aioa?ini?aaioo iie?-ea?aey o oai?eo ia AA c ??ciei nooiaiai aaaeeino?”. Iaoe??ioe aoee ?icae?eai? ia 2 a?oie. Ia?oo a?oio neeaee 54 oai?eo, c ieo 26 (48,1 %) c aaaeeei ? 28 (51,9 %) ?c na?aaeiueiaaaeeei ia?aa?aii aaiaoeoo, ye? io?eioaaee o?aaeeoe?eio oa?ai?th. O 2-o a?oio aa?eoei 44 oai?eo, yeei i?ecia/aee aioa?ini?aaio iie?-ea?aey, c ieo 21 (47,7 %) c aaaeeei ? 23 (52,3 %) ?c na?aaeiueiaaaeeei ia?aa?aii AA. Aioa?ini?aaio oai?? io?eioaaee ii 10 a o?e/? ia aeaiue i?ioyaii 10 aei?a aeiaoyie/iiai ia??iaeo. Aoaeo i?iaaaeaii? oa?ai?? ioe?ithaaee ia iniia? aiae?co ee?i?/iiai ia?aa?ao oai?iae, aeeiai?ee iieaciee?a ooieoe?iiaeueiiai noaio ia/?iee, A?, ?ioiii? oa aioeieneaeaioii? nenoai i?aai?cio. Anoaiiaeaii, ui aeei?enoaiiy iie?-ea?aey o oai?eo ia AA ni?eyei iie?auaiith ?o noa’?eoeaiiai noaio, oaeaeoiio, i?ae o a?oi? ii??aiyiiy, cieaeaiith ??aiy a?e??oa?io oa ne?iaaoeiaeo ai?iio?ainoa?ac. O aeayeeo aeiaaeeao niinoa??aaeiny c?inoaiiy aeoeaiino? aicei?a, yea ia aieeaaei ia caaaeueiee iiceoeaiee aoaeo aioa?ini?aoe??. Iniaeeai nooo?aei aoa aieea i?aia?aoo ia ??aaiue A? i?aai?cio, ui i?e na?aaeiueiaaaeeiio ia?aa?ao aaiaoeoo coiiaeei oaeaeoo ii?iae?caoe?th ie?aieo iieaciee?a (INI, A?EE). I?e aaaeeiio ia?aa?ao aaiaoeoo i?eeii iie?-ea?aey ni?eya aeoeai?o?e ae?i?iaoe?? oienei?a c i?aai?cio, ui i?iyaeeiny iiceoeaiith aeeiai?eith iieaciee?a A? aaea c ia?oeo aei?a e?eoaaiiy. I?e na?aaei?e aaaeeino? AA iie?-ea?aey ia iaa cia/iiai ?ioiio?iiiiai aieeao. O aeiaaeeo aaaeeiai ia?aa?ao caoai?thaaiiy aeyaeaii neaaeee ?ioiiiiaeoethth/ee aieea e?eoaaiiy oeei i?aia?aoii (E?Ae 1,14) ? iiceoeaio aeeiai?eo ?ioiii? a?aeiia?ae?. I?e na?aaeiueiaaaeeiio ia?aa?ao oai?iae i?eeii iie?-ea?aey ni?eya aaeaeaaoi?e ?aaoeyoe?? aeoeaiino? eaoaeace, a i?e aaaeeiio ua e ai?noo oea?oeiieaci?io, ui caaaeii coiiaeei aeinoaoi?e aioeieneaeaioiee caoeno i?aai?cio ca oiiae a??oniiai o?aaeaiiy ia/?iee. C?iaeaii aeniiaie, ui i?eeii aioa?ini?aaioo o oai?eo ?c na?aaeiueiaaaeeei ? aaaeeei ia?aa?aii aaiaoeoo i?ea?a aei iiceoeaii? aeeiai?ee ?ioiii? a?aeiia?ae? oa aioeieneaeaioiiai caoenoo. Iiaeeeaee iaoai?ci aieeao aeoeaia ae?i?iaoe?y aiaeioienei?a c i?aai?cio ?, a?aeiia?aeii, ciyooy ?o i?aneiao ia eiiiiiaioe ?ioiii? nenoaie oa ciaioaiiy ?ioaineaiino? iioeiaeaeoth/i? ae?? a?eueieo ?aaeeeae?a. Io?eiai? ?acoeueoaoe aeicaieythoue ?aeiiaiaeoaaoe iie?-ea?aey aeey eiiieaenii? oa?ai?? oai?eo ?c cia/iei ?ioieneeaoe?eiei neiae?iiii, a o aeiaaeeo aiaeioieneeico I nooiaiy iiai?noth aeeeth/eoe ia?aioa?aeuei? aeaoieneeaoe?ei? caoiaee. O ?icae?e? oinoiio “Aieea aioa?ini?aoe?? ia noai aioeieneaeaioii? nenoaie i?aai?cio o ??ci? oace ?icaeoeo aenia?eiaioaeueiiai oiene/iiai aaiaoeoo” iaaaaeaii iaeaaaeeea?o? ?acoeueoaoe aeia?eiaioaeueii? /anoeie ?iaioe. Iieacaii, ui canoinoaaiiy aioa?ini?aaioo iie?-ea?aey o e?eoaaii? a?eeo uo??a c oao?aoei?iaoaiiaei o?aaeaiiyi ia/?iee ni?eyei ii?iae?caoe?? aeoeaiino? eaoaeace, a a ia/?ioe? /anoeiai cieaeoaaei aeoeai?noue oa?iaioo a on? no?iee aeine?aeaeaiiy. Aioa?ini?aoe?eia oa?ai?y i?ecaaea aei i?aeoe/ii iiaii? ii?iae?caoe?? a ieaci? e?ia? aeoeaiino? aeooao?iiia?ieneaeace oa aeooao?ii?aaeoeoace o oac? aee?iai? aeeno?io??, a aeooao?ii?aaeoeoace – o oac? ?aaaia?aoe?? ia/?ieiai? oeaieie. O ia/?ioe? iieacieee aeoeaiino? aeooao?iiia?ieneaeace aeinoia??ii ia a?ae??ciyeeny a?ae caei?iaeo oaa?ei o oac? aee?iai? aeeno?io??, a aeooao?ii?aaeoeoace – ia noaae?? aee?iai? aeeno?io?? oa ?aaaia?aoe??. I/aaeaeii, ciaioaiiy e?eueeino? oiene/ieo ?a/iaei o ieaci? e?ia? ca ?aooiie ?o ni?aoe?? c o?aaiiai eaiaeo i?ecaiaeeoue aei cieaeaiiy aeoeaiino? ia?aeeniiai ieeneaiiy e?i?ae?a ?, a?aeiia?aeii, aei noaa?e?caoe?? iaia?ai ee?oei. O aeine?aei?e a?oi? oaa?ei oea i?iyaeeiny ciaioaiiyi ai?noo oea?oeiieaci?io o ieaci? e?ia?. C?iaeaii aeniiaie, ui aioa?ini?aoe?eia oa?ai?y i?e oiene/iiio o?aaeaii? ia/?iee ni?ey? i?aeaeuaiith oa?iaioaoeaiiai aioeieneaeaioiaiai caoenoo i?aai?cio. ?icae?e 7 – “Iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiue” – i?enay/aiee ocaaaeueiaiith aeaieo ee?i?ei-a?io?i?/ieo, ?ioiieia?/ieo oa aenia?eiaioaeueieo aeine?aeaeaiue, c?noaaeaii? ?o c aeaieie e?oa?aoo?e. C?iaeaii iaoeiai iaa?oioiaai? aeniiaee. AENIIAEE: 1. O oai?eo c eaaeei ia?aa?aii aino?iai AA neiae?ii A? coiiaeaiee aiaeioienai??th ca?eueoaiiyi ai?noo oiene/ieo i?iaeoeo?a o e?iaiiiniiio ?one? (i?aeaeuothoueny iieacieee NO, INI254). Aiaeioieneeic aaaeeeaiai cia/aiiy o ?icaeoeo iaoieia?/iiai i?ioeano ia ia?. 2. I?e na?aaeiueiaaaeeiio ia?aa?ao AA o iaoiaaiac? neiae?iio A? nooo?ao ?ieue a?ae?a?athoue ye aiaeioienai?y, oae ? aiaeioieneeic, ui i?aeoaa?aeaeo?oueny iiaeaeueoei c?inoaiiyi NO ? ai?noo iaio o?aeoe?e INI e noi?iaiaeaeo?oueny iaa?iiaaeaeaiiyi aiaeioienei?a a ?ioa?noeoe?eiiio i?inoi?? (i?aeaeuaiiy NOE??) oa iii??iei cieaeaiiyi A?EE. 3. I?ia?aeia i?noea o ?icaeoeo neiae?iio A? i?e aaaeeiio ia?aa?ao AA caeiathoue iaoieia?/i? ci?ie, coiiaeai? aiaeioieneeicii. I?e oeueiio oiene/i? i?iaeoeoe ia?aaaaeii eiioeaio?othoueny a ?ioa?noeoe?eiiio i?inoi?? i?aai?cio, aea ?o ??aaiue cia/ii aeuee, i?ae o e?iaiiiniiio ?one?. 4. Ia?aeaeueia aecia/aiiy a aeeiai?oe? oai?iae iieaciee?a aiaeioienai?? oa aiaeioieneeico aeicaiey? ia’?eoeaii ioe?ieoe aaaee?noue AA ? i?iaiicoaaoe iiaeaeueoee eiai ia?aa?a, cie?aia, iiaeeea?noue ?icaeoeo aino?iai aaiaoiiae?ico. I?i eiai caa?ico na?ae/eoue ca?eueoaiiy eiioeaio?aoe?? oienei?a o i?aeee?oeiiiio na?aaeiaeu? iiiaae 9,5 % (ca nia?iaoici?aeiei oanoii) oa ciaioaiiy A?A ieae/a 0,5 oi. iae. ? A?E ieae/a 0,06. 5. ?ioiia a?aeiia?aeue i?aai?cio i?e AA cia/iith i??ith caeaaeeoue a?ae ??aiy A?. I?e ia?aaaaei?e eiioeaio?aoe?? oiene/ieo i?iaeoeo?a o e?iaiiiniiio ?one? ?ioiia nenoaia aaeaeaaoii ?aaao? ia ii?ooaiiy caaaeueiiai aiiainoaco. O ?ac? ca?eueoaiiy e?eueeino? oienei?a oaeiae o i?aeee?oeiiiio na?aaeiaeu? nooo?ai ciaioo?oueny e?euee?noue O-e?ioioeeo?a ? e?cioeeio, c?inoa? /enei iaiiaiioe?iieo iaeiaeeoa?aioe?eiaaieo ee?oei, ??aaiue Oe?E. 6. I?e aaaeeiio ia?aa?ao AA eiioeaio?aoe?y oienei?a o ?ioa?noeoe?? cia/ii aeua, i?ae o e?ia?, ui noi?iaiaeaeo?oueny aeeaieei aoi?eiiei ?ioiiaeao?oeeoii c iaaeinoaoi?noth on?o eaiie ?ioiii? a?aeiia?ae?. O i?aeiiaoiciee ia??iae aeyaeaii aenieo i?yio ei?aeyoe?th (r=+0,74) i?ae ai?noii Oe?E o ne?iaaooe? e?ia? oa eiioeaio?aoe??th oienei?a o ?ioa?noeoe?eiiio i?inoi??. 7. Canoinoaaiiy eiia?iiaaiiai aioa?ini?aaioo iie?-ea?aey o eiiieaeniiio e?eoaaii? oai?eo ia AA ni?ey? ee?i?/iiio iaeoaeaiith, ii?iae?caoe?? a?io?i?/ieo iieaciee?a ooieoe?iiaeueiiai noaio ia/?iee, ei?aeoe?? ?ioiiiai aiiainoaco oa i?aeaeuaiith aeoeaiino? aioeieneaeaioiiai caoenoo i?aai?cio. 8. A aenia?eiaio? ia oaa?eiao aeiaaaeaii iiina?aaeeiaaiee iiaeoethth/ee aieea iie?-ea?aey ia oa?iaioaoeaio AIN ia/?iee oa ieacie e?ia? i?e oiene/iiio oao?aoei?iaoaiiaiio aaiaoeo?. I?eeii iie?-ea?aey o oac? aee?iai? aeeno?io?? nei?i/oaaa oa?i?ie ii?iae?caoe?? aeoeaiino? eaoaeace, aeooao?iiia?ieneaeace oa aeooao?ii?aaeoeoace o ieaci? e?ia? oa ia/?ioe?, ni?eya ciaioaiith ai?noo oea?oeiieaci?io, ui iaoiiaeei iaae?eiee aioeieneaeaioiee caoeno i?aai?cio. ?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy aeaee ciiao noi?ioethaaoe i?aeoe/i? ?aeiiaiaeaoe??: 1. Aeey ooi/iaiiy nooiaiy aaaeeino? AA ? i?iaiicoaaiiy iiaeaeueoiai ia?aa?ao oai?iae aeioe?eueii eiiieaenii aeei?enoiaoaaoe iieacieee aiaeioienai?? oa aiaeioieneeico i?aai?cio. Cai?iiiiiaaii ianooiiee ae?aiacii ?yaeo iieaciee?a, ui na?ae/eoue i?i eaaeee ia?aa?a AA: OE a?ae 0,5 aei 2,5 %, ai?no INI280 a?ae 0,27 aei 0,30 oi. iae., INI254 – a?ae 0,52 aei 0,60 oi. iae., NOE?? a?ae 1,0 aei 4,0 %, A?A a?ae 0,80 aei 0,70 oi. iae., A?E a?ae 0,080 aei 0,071 (I nooi?iue A?). ??aaiue OE a?ae 2,6 aei 5,0 %, INI280 a?ae 0,31 aei 0,35 oi. iae., INI254 – a?ae 0,61 aei 0,65 oi. iae., NOE?? a?ae 4,1 aei 7,0 %, A?A a?ae 0,69 aei 0,60 oi. iae., A?E a?ae 0,075 aei 0,070 aeacothoue ia na?aaei?e nooi?iue aaaeeino? AA (II nooi?iue A?). Ia aaaeeee ia?aa?a AA aeaco? c?inoaiiy OE iiiaae 5,0 %, ai?noo INI280 aeua 0,35 oi. iae., INI254 – aeua 0,65 oi. iae., NOE?? – aeua 7,0 %, a oaeiae ciaioaiiy A?A a?ae 0,60 oi. iae. oa A?E a?ae 0,07 (III nooi?iue A?). 2. C?inoaiiy NOE?? a?eueoa, i?ae 9,5 %, cieaeaiiy A?A ieae/a 0,5 oi. iae. oa A?E ieae/a 0,06 o oai?eo c aaaeeei ia?aa?aii aaiaoeoo na?ae/eoue i?i ?icaeoie ia/?ieiai? eiie. Ine?eueee ci?ie aeacaieo iieaciee?a aeia?aaeaeathoue ?yae ?ioeo iciae aaiaoiiae?ico, oi aiie iiaeooue neoaoaaoe ?aii?ie ia’?eoeaieie e?eoa??yie oeueiai oneeaaeiaiiy. 3. I?e na?aaeiueiaaaeeiio oa aaaeeiio ia?aa?ao AA eiiieaen oa?aiaaoe/ieo na?aaeiee?a aeioe?eueii aeiiiaieoe aioa?ini?aaioii iie?-ea?aey ii 10 a o?e/? ia aeiao ca 2 aiae aei /e i?ney aaeeaaiiy ?ae? i?ioyaii 10 aei?a. Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe?? 1. Aiae?ae/ei I.A., Ie/ee I.A. Bieea aiaeiaaiii? ?ioieneeaoe?? ia ?ioiio nenoaio i?e aino?iio a??oniiio aaiaoeo? A // ?ioaeoe?ei? oai?iae. – 1997. – ? 1. – N. 43-46. 2. Ie/ee I.A. Aeei?enoaiiy iie?-ea?aey o eiiieaeni?e oa?ai?? aino?iai a??oniiai aaiaoeoo A // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1997. – ? 8. – N. 124-129. 3. Ie/ee I.A. I?iaiinoe/ia aaaeeea?noue iieaciee?a aiaeiaaiii? ?ioieneeaoe?? o oai?eo c aaaeeei ? ceiye?niei ia?aa?aii aino?iai aaiaoeoo A // ?ioaeoe?ei? oai?iae. – 1998. – ? 3. – N. 13-16. 4. Iaoiaee aeine?aeaeaiiy aiaeiaaiii? ?ioieneeaoe?? i?aai?cio: Iaoiaee/i? ?aeiiaiaeaoe?? / Aiae?ae/ei I.A., Aao I.Ae., Aeai’yiaiei A.A., Ie/ee A.C., Ie/ee I.A. – Ee?a. – 1998. – 31 n. 5. Ie/ee I.A. Aca?iica’ycie noaio aiaeiaaiii? ?ioieneeaoe?? oa ?ioiii? a?aeiia?ae? i?e aino?iio a??oniiio aaiaoeo? A // Aeooaeuei? i?iaeaie i?e?ia?ieia??, ai?aeai?ieia??, ia?aceoieia?? oa i?io?eaeoeee ?ioaeoe?eieo oai?ia: Iaoa??aee XII c’?caeo Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a, ia?aceoieia?a ?i. Ae.E. Caaieioiiai. – Ee?a-A?iieoey, 1996. – N. 164-164. 6. Ie/ee I.A. Neiae?ii aiaeiaaiii? ?ioieneeaoe?? o oai?eo ia aino?ee a??oniee aaiaoeo A // Aeooaeuei? ieoaiiy ii?oieia??: Ca??iee iaoeiaeo ?ia?o. – Oa?iii?eue, 1996. – N. 468-469. 7. Andreychyn M., Ishchuk I., Gospodarsky I., Nychyk N. Immunomodulators in Acute B Hepatitis Treating // 7th International Congress for Infections Disesases/ Hong Kong, June 10-13, 1996. – 110.001. 8. Aiae?ae/ei I.A., Aioethe C.?., Ie/ee I.A., Ainiiaea?nueeee ?.ss. Oeyoe oaeineiiaeaiiy iaoiaaiaoe/iiai e?eoaaiiy a??onieo aaiaoeo?a // Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? ? ieaioio Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie. – Noie, 1997. – N. 5-6. 9. Aiae?ae/ei I.A., ?uoe ?.N., Ainiiaea?nueeee ?.ss., Aioethe C.?., Ie/ee I.A. Canoinoaaiiy ?ioiiiiaeoeyoi??a o e?eoaaii? oai?eo ia a??oniee aaiaoeo A // Iaoa??aee XL i?aenoieiai? iaoeiai? eiioa?aioe??, i?enay/aii? 40-??/iiio tha?eath aeaaeai??. – Oa?iii?eue, 1997. – N. 23-26. 10. Ie/ee I.A. E?eoaaeueia aoaeoeai?noue aioa?ini?aaioo iie?-ea?aey i?e a??oniiio aaiaoeo? A // I I?aeia?iaeiee iaaee/iee eiia?an nooaeaio?a ? iieiaeeo a/aieo. – Oace aeiiia?aeae. – Oa?iii?eue, 1997. – N. 235-235. 11. Aiae?ae/ei I.A., Ainiiaea?nueeee ?.ss., ?uoe ?.N., Aioethe C.?., Ie/ee I.A. Oaeineiiaeaiiy oa?iaeioa?ai?? a??onieo aaiaoeo?a // Iaoa??aee V c’?caeo ?ioaeoe?ii?no?a Oe?a?ie. – Oa?iii?eue, 1998. – N. 3-5. 12. Ie/ee I.A. Aioeoiene/ia ?acenoaioi?noue ee?oei e?ia? o oai?eo ia aino?ee aaiaoeo A // Nia?aiaiiua aniaeou aiaiiie iaaeeoeeiu: Nai?iee iao/iuo o?oaeia iaaeaeoia?iaeiie iao/ii-i?aeoe/aneie eiioa?aioeee eioaeoeeiienoia e yieaeaieieiaia Aii?oaeaiiuo Nee Oe?aeiu (Aeooaeueiua aii?inu eioaeoieiaee, yieaeaieieiaee e iee?iaeeiaee). – Ee?a, 1998 – N. 301-302. 13. Ie/ee I.A., ?oae/ee A.N. Aieea aioa?ini?aaioo iie?-ea?aey ia ??aaiue aiaeiaaiii? ?ioieneeaoe?? i?aai?cio oai?eo ia aino?ee aaiaoeo A // A?eia? iniaeeaino? ?ioaeoe?eieo oai?ia: Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? ? ieaioio Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie. – Ioea/aai, 1998. – N. 105-106. 14. Ie/ee I., Ni?oea?aiei N. ??aaiue aiaeiaaiii? ?ioieneeaoe?? ye ia’?eoeaiee e?eoa??e aaaeeino? aino?iai aaiaoeoo A // I? I?aeia?iaeiee iaaee/iee eiia?an nooaeaio?a ? iieiaeeo a/aieo. – Oace aeiiia?aeae. – Oa?iii?eue, 1998. – N. 215-216. 15. Aiae?ae/ei I.A., ?uoe ?.N., Ie/ee I.A., ?aao?a I.E., Ai?ae A.I., Ainiiaea?nueeee ?.ss., Eii/a A.N., Ea/i? A.I., E?eei E.A., I?ca? A.A. Aiaeioieneeic i?e aino?iio aaiaoeo? A //Caeiaooee ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie. – Oa?iii?eue, 1999. – N. 9-15. AIIOAOe?ss Ie/ee I.A. Ee?i?ei-?ioiieia?/i? iniaeeaino? aiaeiaaiii? ?ioieneeaoe?? i?e aaiaoeo? A ? aoaeoeai?noue aioa?ini?aoe?eii? oa?ai??. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae. – Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai IIC Oe?a?ie, Ee?a, 1999. Ia iniia? ee?i?/iiai oa eaai?aoi?iiai ianoaaeaiiy 126 oai?eo ia aaiaoeo A anoaiiaeaii, ui ia?aeaeueia aecia/aiiy iieaciee?a aiaeioienai?? oa aiaeioieneeico aeicaiey? ia’?eoeaii ioe?ieoe aaaee?noue AA ? i?iaiicoaaoe iiaeaeueoee eiai ia?aa?a. Aeyaeaii, ui i?e eaaeiio ia?aa?ao aaiaoeoo ?ioieneeaoe?eiee neiae?ii aecia/a?oueny aiaeioieneiaie, ye? ia?aaoaathoue o e?iaiiiniiio ?one?, oiaoi ??aiai aiaeioienai??. Aiaeioieneeic, ye oaeee, ia cia/iee ? nooo?aiai aieeao ia ee?i?/iee ia?aa?a oai?iae ia coiiaeth?. I?e na?aaeiueiaaaeeiio ia?aa?ao aaiaoeoo c?inoa? ??aaiue aiaeioienai?? oa aiaeioieneeico, ui ni?e/eiy? cia/i?o? noa'?eoeai? i?iyae ?ioieneeaoe?? oa noi?iaiaeaeo?oueny ia?inoaiiyi ooieoe?iiaeueieo ?iceaae?a ia/?iee. Aeine?aeaeaiiy A? i?aai?cio i?e aaaeeiio ia?aa?ao AA aeaee ciiao aeyaeoe oa?aeoa?i? ci?ie iieaciee?a aiaeioieneeico, ye? aeiiiiiaathoue ia?aaeaa/eoe iiaeeeaee ?icaeoie ia/?ieiai? eiie. Aeyaeaia caeaaei?noue i?ae aeayeeie iieacieeaie A? oa ?ioi?oaoo aeicaiey? ?icoe?ithaaoe ?iceaaee a ae?yeueiino? ?ioiii? nenoaie ye iaoaaie?/io ?ioiinoi?an?th. Canoinoaaiiy eiia?iiaaiiai aioa?ini?aaioo iie?-ea?aey o eiiieaeniiio e?eoaaii? oai?eo ia AA ni?ey? ee?i?/iiio iaeoaeaiith, ii?iae?caoe?? a?io?i?/ieo iieaciee?a ooieoe?iiaeueiiai noaio ia/?iee, ei?aeoe?? ?ioiiiai aiiainoaco oa i?aeaeuaiith aeoeaiino? aioeieneaeaioiiai caoenoo i?aai?cio. A aenia?eiaio? ia oaa?eiao aeiaaaeaii iiina?aaeeiaaiee iiaeoethth/ee aieea iie?-ea?aey ia oa?iaioaoeaio aioeieneaeaioio nenoaio ia/?iee oa ieacie e?ia? i?e oiene/iiio oao?aoei?iaoaiiaiio aaiaoeo?. I?eeii iie?-ea?aey o oac? aee?iai? aeeno?io?? nei?i/oaaa oa?i?ie ii?iae?caoe?? aeoeaiino? eaoaeace, aeooao?iiia?ieneaeace oa aeooao?ii?aaeoeoace o ieaci? e?ia? oa ia/?ioe?, ni?eya ciaioaiith ai?noo oea?oeiieaci?io, ui iaoiiaeei iaae?eiee aioeieneaeaioiee caoeno i?aai?cio. Eeth/ia? neiaa: aaiaoeo A, aiaeioienai?y, aiaeioieneeic, aioa?ini?aoe?y, e?eoaaiiy, iie?-ea?aey. ANNOTATION Nychyk N.A. Clinicoimmunologic peculiarities of endogeneous intoxication in hepatitis B and enterosorption therapy efficiency – Manuscript. The thesis for receiving the candidate of medical sciences degree, speciality 14.01.13. – infectious diseases. – L.V. Gromashevsky research institute of epidemiology and infectious diseases, Kyiv, 1999. The clinical and laboratory examination of 126 patients with hepatitis B revealed the importance of simultaneous endotoxemia and endotoxicosis indices determination for the objective estimation of HB severity and the prognosis of its further development. It was revealed that in a mild form of hepatitis, intoxication syndrome is determined by endotoxins located in blood, that is endotoxemia level. There are no significant manifestations of endotoxicosis and it does not produce essential influence on the development of disease. In moderate form of hepatitis endotoxemia and endotoxicosis levels increase that results in clearer subjective manifestations of intoxication, accompanied by increased functional disorders of the liver. Revealed dependence between some EI indices gives us basis to consider immunologic system disorders as metabolic immunosuppression. The use of combined enterosorbent poly-karaya in complex treatment of patients with hepatitis B contributes to clinical recovery, biochemical indices of the hepatic function normalization, immunologic homeostasis correction and antioxidant protective activity increase. The experiments made on the animals proved poly-karaya indirect stimulative influence on the enzyme antioxidant hepatic system and blood plasma in case of toxic tetrachloromethanic hepatitis. The poly-karaya application in fat dystrophy phase decreased cattalase, glutationperoxidase and glutationreductase normalization terms, contributed to ceruplasmin contents decreasing which resulted in reliable antioxidant protection of the organism. Key-words: endotoxemia, endotoxicosis, enterosor?tion, hepatitis B, poly- karaya, treatment. AIIIOAOeEss Iu/ee I.A. Eeeieei-eiioiieiae/aneea iniaaiiinoe yiaeiaaiiie eioieneeaoeee i?e aaiaoeoa A e yooaeoeaiinoue yioa?ini?aoeeiiiie oa?aiee. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.13 – eioaeoeeiiiua aieacie. – Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei. E.A. A?iiaoaaneiai IIC Oe?aeiu, Eeaa, 1999. ?aaioa iinayuaia aii?inai aeeaaiinoeee e ea/aiey ino?iai aaiaoeoa A. Oeaeue ?aaiou: ii?aaeaeeoue eeeieei-iaoiaaiaoe/aneea iniaaiiinoe yiaeiaaiiie eioieneeaoeee (YE) o aieueiuo ino?ui aaiaoeoii A (AA) n ?aciie noaiaiueth oyaeanoe, aeeyiea yiaeioienaiee e yiaeioieneeica ia ninoiyiea eiioiiie nenoaie i?aaiecia e aiciiaeiinoue eo ei??aeoeee i?e iiiiue yioa?ini?aaioa iiee-ea?aey. O?iaaiue yiaeioienaiee ioeaieaaee ca ia?aiao?aie nia?iaoicieaeiiai oanoa e eiioeaio?aoeeae iieaeoe n?aaeiae iannu (INI). Aeoaeio yiaeioieneeica enneaaeiaaee ca ?aaeoeeyie aioeoiene/aneie ?acenoaioiinoe eaeeioeeoia e y?eo?ioeeoia (A?E, A?Y), noiia?iie oiene/iinoueth e?iae e eioa?noeoeeaeueiie aeeaeeinoe (NOEEAE). Eiioiiue noaoon ii?aaeaeyee ii iaeioi?ui ia?aiao?ai eeaoi/iiai e aoii?aeueiiai eiioieoaoa. Ianeaaeiaaiea i?iaiaeeee: 1) a ?acaa? aeaeoooiiai ia?eiaea aieacie, iaeneiaeueiie au?aaeaiiinoe aa eeeie/aneeo e aeioeie/aneeo i?iyaeaiee, ia?aae eo?nii ea/aiey; 2) a noaaeee niaaea aeaeoooe, iinea ai?iae?iaaiiiai eo?na ea/aiey; 3) a noaaeee ?aiiae ?aeiiaaeanoeaioeee (ia?aae auieneie). Ia iniiaaiee eeeie/aneiai e eaai?aoi?iiai ianeaaeiaaiey 126 aieueiuo ino?ui AA auei onoaiiaeaii, /oi neiae?ii YE o aieueiuo c eaaeei oa/aieai AA iaoneiaeai yiaeioienaieae – iiauoaieai niaea?aeaiey oiene/aneeo i?iaeoeoia a e?iaaiiniii ?onea. I?e yoii aic?inoatho cia/aiey iieacaoaeae OE e INI254. ?ieue yiaeioieneeica a ?acaeoee iaoieiae/aneiai i?ioeanna o oaeeo aieueiuo ia nouanoaaiia. I?e n?aaeiaoyaeaeii oa/aiee AA neiae?ii YE aue iaoneiaeai eae yiaeioienaieae, oae e yiaeioieneeicii. Yoi iiaeoaa?aeaeaeinue oooaeoaieai iauaai ninoiyiey aieueiuo, aeaeueiaeoei iiauoaieai OE, niaea?aeaiey iaaeo o?aeoeee INI. Nouanoaaiii aic?inoaea eiioeaio?aoeey yiaeioieneiia a eioa?noeoeeaeueiii i?ino?ainoaa. Ia yoii naeaeaoaeuenoaiaaei iiauoaiea NOEEAE e oia?aiiia nieaeaiea A?EE. Aaaeouay ?ieue a ?acaeoee neiae?iia YE i?e oyaeaeii oa/aiee AA i?eiaaeeaaeeo iaoieiae/aneei eciaiaieyi a i?aaiecia, iaoneiaeaiiui cia/eoaeueiui yiaeioieneeicii. I?e yoii oiene/aneea i?iaeoeou aeaaiui ia?acii eiioeaio?e?othony a eioa?noeoeeaeueiii i?ino?ainoaa i?aaiecia, aaea eo o?iaaiue cia/eoaeueii auoa, /ai a e?iaaiiniii ?onea. I?e iaiieiioeaiiii ooieoeeiie?iaaiee aeaoieneeaoeeiiiuo nenoai i?aaiecia eee a neo/aa iaaaeaeaaoiiai ea/aiey yoi i?eaiaeeo e ?acaeoeth ia/aii/iie iaaeinoaoi/iinoe. Naeaeai auaiae, /oi ia?aeeaeueiia ii?aaeaeaiea a aeeiaieea aieacie iieacaoaeae yiaeioienaiee e yiaeioieneeica aeaao aiciiaeiinoue iauaeoeaii ioeaieoue oyaeanoue AA e i?iaiice?iaaoue aeaeueiaeoia aai oa/aiea, a /anoiinoe, aiciiaeiinoue ?acaeoey ino?iai aaiaoiiae?ica. Ia aai oa?ica naeaeaoaeuenoaotho iiauoaiea eiioeaio?aoeee oieneiia a iaaeeeaoi/iii i?ino?ainoaa auoa 9,5 % (ca NO) e nieaeaiea A?A ieaea 0,5 one. aae. e A?E ieaea 0,06. Eiioiiue ioaao i?aaiecia i?e AA nouanoaaiii caaeneo io o?iaiy YE. I?e i?aeiouanoaaiiie eiioeaio?aoeee oiene/aneeo i?iaeoeoia a e?iaaiiniii ?onea eiioiiay nenoaia aaeaeaaoii ?aaae?oao ia ia?ooaiey iauaai aiiainoaca. A neo/aa iiauoaiey eiee/anoaa oieneiia aeaaiui ia?acii a eioa?noeoeeaeueiii i?ino?ainoaa nieaeaaony eiee/anoai O-eeioioeeoia e eiioeaio?aoeey eecioeeia, ?anoao /enei iaiieiioeaiiuo iaeiaeeooa?aioee?iaaiuo eeaoie, o?iaaiue OeEE. I?e oyaeaeii oa/aiee AA eiioeaio?aoeey oieneiia a eioa?noeoeee cia/eoaeueii auoa, /ai a e?iae, /oi nii?iaiaeaeaaony aeoaieei aoi?e/iui eiioiiaeaoeoeeoii n iaaeinoaoi/iinoueth anao caaiueaa eiioiiiai ioaaoa. A i?aeiiaoiciue ia?eiae iaia?oaeaii aunieoth i?yioth ei??aeyoeeth (r=+0,74) iaaeaeo niaea?aeaieai OeEE a nuai?ioea e?iae e eiioeaio?aoeeae oieneiia a eioa?noeoeeaeueiie n?aaea. Iieacaii, /oi i?eiaiaiea eiiaeie?iaaiiai yioa?ini?aaioa iiee-ea?aey a eiiieaeniii ea/aiee aieueiuo AA niinianoaoao aieaa auno?iio eeeie/aneiio aucaei?iaeaieth, ii?iaeecaoeee aeioeie/aneeo iieacaoaeae ooieoeeiiaeueiiai ninoiyiey ia/aie, ei??aeoeee eiioiiiai aiiainoaca e iiauoaieth aeoeaiinoe aioeieneaeaioiie caueou i?aaiecia. A yenia?eiaioa ia aeeaioiuo aeieacaii einaaiiia iiaeoee?othuaa aeeyiea iiee-ea?aey ia oa?iaioaoeaioth AIN ia/aie e ieaciu e?iae i?e oiene/aneii oao?aoei?iaoaiiaii aaiaoeoa. I?eai iiee-ea?aey a oaca aee?iaie aeeno?ioee nie?auae no?iee ii?iaeecaoeee aeoeaiinoe eaoaeacu, aeooaoeiiia?ieneaeacu e aeooaoeii?aaeoeoacu a ieacia e?iae e ia/aie, niinianoaiaae nieaeaieth niaea?aeaiey oea?oeiieacieia, /oi iaoneiaeei iaaeaaeioth aioeieneaeaioioth caueoo i?aaiecia. Eeth/aaua neiaa: aaiaoeo A, ea/aiea, iiee-ea?aey, yiaeioienaiey, yiaeioieneeic, yioa?ini?aoeey.

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