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Клініко-імунологічне та комп’ютерно-спірографічне обгрунтування використання уролесану та імуналу у комплексному лікуванні хронічного обструктивного б

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I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y

Ia i?aaao ?oeiieno

INO?IANUeEEE IEEIEA IEEIEAEIAE*

OAeE : 616.223.002 + 616-071-059+547.914+576.8.007.3+616.24-073.173.

Ee?i?ei-?ioiieia?/ia oa eiii’thoa?ii-ni??ia?ao?/ia iaa?oiooaaiiy
aeei?enoaiiy o?ieanaio oa ?ioiaeo o eiiieaeniiio e?eoaaii? o?ii?/iiai
iano?oeoeaiiai a?iio?oo.

Niaoe?aeuei?noue 14.01.02 – aioo??oi? oai?iae

AAOI?AOA?AO

AeENA?OAOe?? IA CAeIAOOOss IAOEIAIAI NOOIAIss

EAIAeEAeAOA IAAeE*IEO IAOE

?aaii-O?aie?anuee – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?aaii-O?aie?anuee?e aea?aeaai?e iaaee/i?e aeaaeai??,
IIC Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?, I?iao Noaiai
ss?ineaaiae/,?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y,
caa?aeoaa/ eaoaae?e aini?oaeueii? oa?ai?? ?2

Iaoeiaee eiinoeueoaio: aeieoi? iaaee/ieo iaoe, aeioeaio, Aeaa? Iao?i
Aaneeueiae/, ?aaii-O?aie?anueea aea?aeaaia iaaee/ia aeaaeai?y, i?ioani?
eaoaae?e oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?, Oaaae Ieeiea
?aaiiae/, Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.
Ai?aa/aanueeiai, caa?aeoaa/ eaoaae?e oaeoeueoaonueei? oa?ai?? aeieoi?
iaaee/ieo iaoe, i?ioani?, Iaeaiueeee Aaneeue Iaaeiae/, A?iieoeueeee
aea?aeaaiee iaaee/iee oi?aa?neoao ?i.I.?. Ie?iaiaa, caa?aeoaa/ eaoaae?e
aini?oaeueii? oa?ai?? ?1

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey, eaoaae?a aini?oaeueii? oa?ai?? ?2, IIC Oe?a?ie,
i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 19 “ aa?aciy 1999?ieo i 13 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 20.601.01 i?e
?aaii-O?aie?anuee?e aea?aeaai?e iaaee/i?e aeaaeai?? (284000, i.?aaii-
O?aie?anuee, aoe.Aaeeoeueea, 2).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?aaii-O?aie?anueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (284000, i.?aaii-O?aie?anuee,
aoe.Aaeeoeueea, 7).

Aaoi?aoa?ao ?ic?neaiee “19“ ethoiai 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii?

?aaee, aeieoi? iaaee/ieo iaoe,

i?ioani? I.A.I?ei/ae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie.

O?ii?/i? iano?oeoeai? caoai?thaaiiy eaaaiue (OICE), a ianaiia?aae
o?ii?/iee iano?oeoeaiee a?iio?o (OIA), ? aaaeeeaith
iaaeeei-nioe?aeueiith i?iaeaiith, yea coiiaeaia ?o aaeeeith iioe?ai?noth
oa cia/iith ?iaae?aeecaoe??th i?aoeacaeaoiiai ianaeaiiy (Eeaeia? A. ?.,
Iaeio/aiei A.I., AaoooeaieiA.A.,1991). *anoioa o?aaeaiiy o?ii?/iei
a?iio?oii neeaaea? a?ae 8 aei 12%, a o o?aoei? aeiaaee?a inoaii?e
ii?aeio?oueny c iano?oeoeaiei ii?ooaiiyi eaaaiaai? aaioeeyoe?? (Oi?ioo?e
I.Ae. *aciaa E.A., Caaei?iaeia O.A. ? ni?aaao., 1993), ui i?ecaiaeeoue
aei ?iaae?aeecaoe?? oa nia?oiino? oai?eo. Caoai?thaai?noue ia OICE
c?inea c 1982 ?ieo ia 42% o caaaeuei?e iiioeyoe??, a o ethaeae iioeeiai
a?eo aeinyaea ??aiy o?aaeaiue na?oeaai-noaeeiii? nenoaie (Celli
B.R.1995). A Oe?a?i? aeecueei 8 i?eueeii?a, a o ?aaii-O?aie?anuee?e
iaeano? i?eaeecii 400 oeny/ in?a no?aaeaeathoue ia o?ii?/i? iano?oeoeai?
caoai?thaaiiy eaaaiue (I?iao N.ss. oa ni?aaao.,1998).

O no?oeoo?? caaaeueii? ?iaae?aeecaoe?? OICE caeiathoue 18,5 –21,5%
(Noeaaaa E.E.,1994; Oeeiaaea? A. oa ni?aaao.,1994), a oaeiae ?
/aoaa?oith i?ia?aeiith i?e/eiith nia?oiino?. Ca aeaieie Huggins H. W. oa
ni?aaao. (1997) o NOA ai?iaeiaae 1966-1996 ?ie?a eaoaeuei?noue a?ae OICE
ca?eueoeeanue ia 26% ? o 1996 ?ioe? aeinyaea 3-8% on?o aeiaaee?a nia?o?.
Ie??i oeueiai anoaiiaeaii, ui nia?oi?noue i?e OICE neeaaea? 66,0% /a?ac
10 ?ie?a oa 92,0% /a?ac 20 ?ie?a a?ae iiiaioo iiyae caaeeoee (Iooia I.A.
oa ni?aaao., 1989; Oauaiei TH. ?.,1998), a ?? caaaeueiee ??no
ca?eueoeany c 1979 ?ieo ia 33% (Nall? A.R., 1995).

I?iaeaia OIA, ye neeaaeiai? /anoeie OICE, ? iaei??th ?c iaea?eueo
aeooaeueieo o no/ani?e ioeueiiiieia??. Oea iia’ycaii c eiai cia/iith
?iciianthaeaeai?noth (Iooia I.A. oa ni?aaao.,1989; Ieooeia A.A. oa
ni?aaao.,1994; Ooaecee ?. oa ni?aaao.,1994; Ialin A.,1991),
oaiaeaioe??th aei iiaeaeueoiai c?inoaiiy (Oauaiei TH.?.,1993; 1998;
Aiaaoeeay A.A. oa ni?aaao., 1995; Ianfred I.,1991), iaeith aoaeoeai?noth
e?eoaaeueieo cania?a (Aoe?aaaa A.A. oa ni?aaao.,1991; Aecthaeee
A.ss.,1993), cia/ieie nioe?aeueii-aeiiii?/ieie caeoeaie, ye? iana a?ae
oeueiai caoai?thaaiiy noni?euenoai (Noeaaaa E.E.,1994; Oeeiaaea?
A.A.,1994). Iaaia /anoeia o?oaeiiu?a, ye? noiyoue ia caaaae? ae??oaiiy
i?iaeaie OIA coiiaeai? a?aenooi?noth aea?aeaaii? i?ia?aie ai?ioueae c
othothiiiae?iiyi, iani?eyoeeaeie aeieia?/ieie oa aaiaoe/ieie oaeoi?aie
(Oauaiei TH.?..1998, Iinoiaee TH.I.,1993); iaae??a?noth caoiae?a aeey
nai?/aniiai aeyaeaiiy oa i?io?eaeoeee oeueiai caoai?thaaiiy (Iaeaaa
I.?.,1990); iaaeineiiae?noth iaoeo ciaiue i?i iaoiaaiac caoai?thaaiiy,
iaoai?cie, ui ni?eythoue eiai i?ia?anoaaiith oa aeieeiaiith
?acenoaioiino? aei oa?ai?? (*a?iooaiei E.O.,1993; Aaa?eiie A.E.oa
ni?aaao.,1995).

A e?oa?aoo?? iayai? o?eueee iiiaeeiie? iia?aeiieaiiy i?i canoinoaaiiy
o?ieanaio oa ?ioiaeo o eiiieaeni?e oa?ai?? eaaaiaai? iaoieia??.

Iiaeia ia?aaeaa/eoe, ui canoinoaaiiy oeeo i?aia?ao?a, yeei i?eoaiaiia
a?iioie?oe/ia, aioeieneaeaioia, iaia?aiinoaa?euecoth/a, i?ioecaiaeueia
oa ?ioiiiiaeoethth/a ae??, ni?eyoeia nei?i/aiith o?eaaeino? e?eoaaiiy oa
iiaeiaaeaiith ?ai?n?? caoai?thaaiiy, i?aeaeueoue aoaeoeai?noue aaciai?
oa?ai?? oa ye?noue ? o?eaae?noue aeeooy oai?eo ia OIA.

Ia?ae?/ai? aeua ia ae??oai? i?iaeaie e?eoaaiiy OIA e iaoiiaeee
aeooaeuei?noue i?iaaaeaiiai aeine?aeaeaiiy, iaoo oa caaaeaiiy ?iaioe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa aeeiiaia o ?aieao iaoeiai? oaiaoeee aeaaeai?/ii?
a?oie aeaaeai?ea AII Oe?a?ie ?.I.Iaeea oa ca?aeii c ieaiii
iaoeiai-aeine?aeieo ?ia?o ?aaii-O?aie?anueei? aea?aeaaii? iaaee/ii?
aeaaeai??: “?ic?iaea iiaeo iaaee/ieo oaoiieia?e oa noaiaea?o?a yeino?
e?eoaaiiy iaeaaaeeea?oeo ia?ioaeoe?eieo caoai?thaaiue” (oeo?
01.02.032.96i).

?iaioa oaeiae ? o?aaiaioii eiiieaeniiai iaoeiaiai aeine?aeaeaiiy
eaoaae?e aini?oaeueii? oa?ai?? ?2 ?aaii-O?aie?anueei? aea?aeaaii?
iaaee/ii? aeaaeai??: “Ee?i?ei-?ioiieia?/i?, iaaeeei-aaiaoe/i? oa
eiii’thoa?ii-ni??ia?ao?/i? iniaeeaino? ia?aa?ao o?ii?/ieo iano?oeoeaieo
caoai?thaaiue eaaaiue oa ?o iaaeeeaiaioicia ei?aeoe?y” (?a?no?aoe?eiee
iiia? AI 01.02.034.96).

Iaoa ?iaioe.

Aeine?aeeoe aeoeai?noue nenoaie no?oaeoaioo eaaaiue oa ?ioiieia?/io
?aaeoeai?noue i?aai?cio i?e ??cieo noaae?yo aaaeeino? ia?aa?ao OIA ?
aea/eoe ?o ci?ie a i?ioean? eiiieaenii? oa?ai?? ?c canoinoaaiiyi
o?ieanaio oa ?ioiaeo.

Caaaeaiiy ?iaioe.

1. Aecia/eoe aeoeai?noue nenoaie no?oaeoaioo eaaaiue oa ??aaiue
e?cioeeio ne?iaaoee e?ia? ? a?iio?aeueiiai nae?aoo a caeaaeiino? a?ae
aaaeeino? ia?aa?ao OIA.

2. Aeine?aeeoe iniaeeaino? ci?i ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo a
caeaaeiino? a?ae noaae?? OIA.

3. Aea/eoe aieea caaaeueiii?eeiyoi? oa?ai?? ia iieacieee ?ioiii?
?aaeoeaiino?, no?oaeoaioo, e?cioeeio oa a?iio?aeueii? i?io?aeiino?.

4. Ioe?ieoe aieea o?ieanaio oa ?ioiaeo ia nenoaio no?oaeoaioo eaaaiue
(NNE), ??aaiue e?cioeeio ne?iaaoee e?ia? ? a?iio?aeueiiai nae?aoo,
?ioiiee noaoon oa a?iio?aeueio i?io?aei?noue o oai?eo ia OIA.

5. Aea/eoe iniaeeaino? aieeao ii?aeiaiiai e?eoaaiiy o?ieanaiii oa
?ioiaeii o eiiieaeni?e oa?ai?? ia ?ioiio ?aaeoeai?noue, noai no?oaeoaioo
eaaaiue, a?iio?aeueii? i?io?aeiino?, ??ai?a e?cioeeio ne?iaaoee e?ia? oa
a?iio?aeueiiai nae?aoo.

Iaoeiaa iiaecia.

I?iaaaeaiei aeine?aeaeaiiyi anoaiiaeaia i?yia ei?aeyoe?eia caeaaei?noue
i?ae cieaeaiiyi iieaciee?a ?ioiieia?/ii? ?aaeoeaiino?, ??aiyie
aeoeaiino? nenoaie no?oaeoaioo eaaaiue oa e?cioeeio, c iaeiiai aieo, ?
iia??oaiiy a?iio?aeueii? i?io?aeiino? o oai?eo ia OIA c ?ioiai.

Aia?oa anoaiiaeaii, ui ii?aeiaia canoinoaaiiy o?ieanaio a eiiieaeniiio
e?eoaaii? i?ecaiaeeoue aei a??ia?aeiiai c?inoaiiy ??aiy e?cioeeio, ye
ne?iaaoee e?ia?, oae ? a?iio?aeueiiai nae?aoo. Anoaiiaeaii ae?aaeaiee
?ioiiiiaeoethth/ee aieea ?ioiaeo, yeee i?iyaey?oueny ca?eueoaiiyi ??ai?a
CD 3, CD 4, CD 56 (NK), ?II 47, ?II 3 ia oii? ciaioaiiy ?II 24, CD 8
iiceoeaieo ee?oei ; ciaioaiiyi ai?noo ?ioiiaeiaoe?i?a eeano I,D,A oa G
i?e ia?inoaii? eiioeaio?aoe?? ?ioiiaeiaoe?i?a eean?a A oa s?gA o
a?iio?aeueiiio nae?ao?. Aia?oa aeieacaii, ui ii?aeiaia canoinoaaiiy
o?ieanaio oa ?ioiaeo o eiiieaeniiio e?eoaaii? oai?eo ia OIA
noi?iaiaeaeo?oueny ii?iae?caoe??th aeoeaiino? NNE, ??ai?a
?ioiiaeiaoe?i?a, e?cioeeio ne?iaaoee e?ia? ? a?iio?aeueiiai nae?aoo oa
noaiiioeyoe?e O- ? A-e?ioioeeo?a.

Aeiaaaeaii aeioe?euei?noue ii?aeiaiiai canoinoaaiiy o?ieanaio oa ?ioiaeo
a eiiieaeniiio e?eoaaii? oai?eo ia OIA, iniaeeai i?e ae?aaeaiiio
a?iioiiano?oeoeaiiio neiae?ii?, cieaeai? ?ioiieia?/ii? ?aaeoeaiino?
i?aai?cio, aeoeaiino? NNE oa ??aiy e?cioeeio ne?iaaoee e?ia? ?
a?iio?aeueiiai nae?aoo.

I?AEOE*IA CIA*AIIss IO?EIAIEO ?ACOEUeO?A.

Iia??oaiiy a?iio?aeueii? i?io?aeiino?, aecia/aii? ca aeiiiiiaith
eiii’thoa?ii? ni??ia?ao??, noi?iaiaeaeo?oueny cieaeaiiyi ?ioiii?
?aaeoeaiino? i?aai?cio c iaeii/aniei ciaioaiiyi aioeaoaeaeoaoe/iiai
oaeoi?o eaaaiue oa aioeaaeoa??aeueiiai aa?’??o a?iio?aeueiiai aea?aaa.
Canoinoaaiiy o?aaeeoe?eii? iaaeeeaiaioicii? oa?ai?? o oai?eo ia OIA
noi?iaiaeaeo?oueny iie?auaiiyi iieaciee?a ?ioiii? ?acenoaioiino? oa
a?iio?aeueii? i?io?aeiino?, c?inoaiiyi ??ai?a aeoeaiino? NNE ?
e?cioeeio. ?acii c oei a oaeeo oai?eo caeeoathoueny ci?iaieie aeua
ia?a?aoiaai? iieacieee, ui neoao? oiiaaie aei ?aoeeaeeao ? i?ia?anoaaiiy
aeaiii? iaaeoae. Eiiieaenia e?eoaaiiy ?c ii?aeiaiei canoinoaaiiyi
o?ieanaio oa ?ioiaeo ni?ey? ii?iae?caoe?? aeaieo eiii’thoa?ii?
ni??ia?ao??, ?ioiiiai noaoono i?aai?cio, a?aeiiaeaiith aeoeaiino? NNE,
??ai?a e?cioeeio ne?iaaoee e?ia? oa a?iio?aeueiiai nae?aoo.
Aeeoa?aioe?eiaaiee aea?? iaaeeeaiaioicieo cania?a ni?ey? a?eueo oaeaee?e
?ai?n?? niaeaoo OIA oa a?aeiiaeaiith a?iio?aeueii? i?io?aeiino?.

Ai?iaaoe?y ?iaioe.

Iniiai? iieiaeaiiy aeena?oaoe?eiiai aeine?aeaeaiiy aeiiia?aeaeeny oa
iaaiai?thaaeeny ia ?? c’?cae? ooec?ao??a ? ioeueiiiieia?a Oe?a?ie
(Ee?a,1998); ia i?aenoieia?e iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo
a/aieo (i.?aaii-o?aie?anuee, 1997); ia can?aeaii? a/aii? ?aaee
?aaii-O?aie?anueei? aea?aeaaii? iaaee/ii? aeaaeai??,1998.

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 6 ?ia?o, ?c ieo 4 o oaoiaeo
aeo?iaeueieo aeaeaiiyo ?aeiiaiaeiaaieo AAE Oe?a?ie.

?aae?caoe?y ?iaioe.

?acoeueoaoe aeine?aeaeaiiy ai?i?aaaeaeaii? a e?eoaaeueii-ae?aaiinoe/iee
i?ioean ioeueiiiieia?/iiai oa ae?aaiinoe/iiai a?aeae?eaiue iaeaniiai
ooec?iioeueiiiieia?/iiai oeaio?o e ioeueiiiieia?/ieo eaa?iao?a i?nueeeo
oa iaeanii? iie?ee?i?e, canoiniaothoueny i?e e?eoaaii? oai?eo ia OIA o
oeaio?aeueieo ?aeiiieo e?ea?iyo oa iie?ee?i?eao. Iaoa??aee aeena?oaoe??
aeei?enoiaothoueny a o/aiaiio i?ioean? ia eaoaae?? aini?oaeueii? oa?ai??
?2, eaoaae?? oaeoeueoaonueei? oa?ai?? iaaee/iiai oaeoeueoaoo
?aaii-O?aie?anueei? aea?aeaaii? iaaee/ii? aeaaeai?? i?e aea/aii?
nooaeaioaie oaie “O?ii?/i? iano?oeoeai? caoai?thaaiiy eaaaiue”.

Ca ?acoeueoaoaie aeena?oaoe?? aeaeai? iaoiaee/i? aeac?aee: “O?ii?/iee
iano?oeoeaiee a?iio?o”, “Iaoiaeeea ioe?iee ?ioiiiai noaoono oa noaie
?ioiiei?aaoth/i? oa?ai?? o ioeueiiiieia??”, ?ic?iaeai? 2
?aoe?iiae?caoi?nuee? i?iiiceoe??:

– i?enoinoaaiiy aeey i?iaaaeaiiy i?e?iiaoiae?a aeine?aeaeaiiy ee?oei
e?ia? (?7/2344 ?OAeIA);

– iaoiae o?aeoe?eiiai aecia/aiiy aeoeaiino? nenoaie no?oaeoaioo eaaaiue
(?14/2351 ?OAeIA).

O i?ioean? aeeiiaiiy ?iaioe iiaeaii aei iaeaniiai “?a?no?o
iaaeeei-a?ieia?/ieo iiaiaaaaeaiue o i?aeoeeo ioi?iie caei?ia’y” oae?
iaoa??aee: “Iaoiae aecia/aiiy aeoeaiino? no?oaeoaioo eaaaiue”,
“E?euee?nia aecia/aiiy nae?aoi?iiai ?ioiiaeiaoe?io A oa e?cioeeio o
a?iio?aeueiiio nae?ao?”.

Aeaeea?aoe?y iniaenoiai aianeo aeena?oaioa a ?ic?iaeo iaoeiaeo
?acoeueoao?a, ui aeiinyoueny ia caoeno.

Aaoi? aeeiiaa iiooe e?oa?aoo?ieo aeaea?ae, aea?aa oaio aeine?aeaeaiiy,
aeia?a i??i?eoaoi?noue, aeioe?euei?noue ? iaiao?aei?noue cae?eniaiiy
caaeoio, aecia/ea iaoo, caaaeaiiy, ia’?i oa iaoiaee aeine?aeaeaiiy,
yeeie aeineiiaei iaieiae?a, i?ieoiaoe eo?ne oa io?eiaaoe aeiionee aei
?iaioe ca no/anieie iaoiaeeeaie. I?ia?a ee?i?ei-?ioiieia?/ia ianoaaeaiiy
oa noaoenoe/io ia?iaeo io?eiaieo aeaieo. I?iaiae?coaaa ? ocaaaeueiea
io?eiai? ?acoeueoaoe, iine?aeiaii ai?iaaaeea ?o o i?aeoeeo. Iiooeoaa/
aia?oa aeine?aeea aeoeai?noue NNE, ??ai? ?ioiiaeiaoe?i?a ? e?cioeeio
ne?iaaoee e?ia? oa a?iio?aeueiiai nae?aoo, noaiiioeyoe?e O- ?
A-e?ioioeeo?a ia?aoa?e/ii? e?ia? i?e ??cieo noaae?yo aaaeeino? ia?aa?ao
OIA ? aeia?a iiceoeaiee aieea ia aeyaeai? c?ooaiiy ii?aeiaiiai
canoinoaaiiy o?ieanaio oa ?ioiaeo a eiiieaeniiio e?eoaaii? oai?eo ia
OIA.

Ianya ? no?oeoo?a aeena?oaoe??.

Aeena?oaoe?y iiaoaeiaaia ca caaaeueii i?eeiyoei ieaiii ? neeaaea?oueny
c anooio, iaeyaeo e?oa?aoo?e, iieno ia’?eoo oa iaoiaeee aeine?aeaeaiiy,
?icae?eo aeanieo niinoa?aaeaiue oa aeine?aeaeaiue, iaaiai?aiiy
?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa aeac?aieea
e?oa?aoo?e. Iaoa??aee aeena?oaoe?? aeeeaaeaii ia noi??ieao. Aeena?oaoe?y
i?noeoue 16 oaaeeoeue oa 18 iaethie?a. A?ae?ia?ao?/iee aeac?aiee
e?oa?aoo?e aeeth/a? 284 aeaea?aea.

Ci?no aeena?oaoe??.

Iaoa??ae oa iaoiaee aeine?aeaeaiiy.

Aeey ae??oaiiy iinoaaeaiieo a ?iaio? caaaeaiue ianoaaeaii 100 oai?eo ia
OIA, ye? ciaoiaeeeeny ia noaoe?iia?iiio ianoaaeaii? oa e?eoaaiaii? o
ioeueiiiieia?/iiio a?aeae?eaii? iaeaniiai ee?i?/iiai
ooec?iioeueiiiieia?/iiai oeaio?o ( i.?aaii-O?aie?anuee ) oa 38 i?aeoe/ii
caei?iaeo in?a. Na?aae oai?eo /ieia?e?a aoei 58 (58%), ae?iie – 42(42%).

Ae?aaiic OIA anoaiiaethaaany ia i?aenoaa? ee?i?ee oa ?ino?oiaioaeueieo
iaoiae?a ianoaaeaiiy, ye? aeeth/aee eiii’thoa?io ni??ia?ao?th,
?aioaaiia?ao?th i?aai?a a?oaeii? ee?oee, o?a?ia?iioineii?th, AEA. On?
oai??, ye? aoee aeeth/ai? o aeine?aeaeaiiy, iaee ee?i?/io ea?oeio
caaino?aiiy OIA. Na?aaeiy o?eaae?noue caoai?thaaiiy aei??aithaaea 12,8
+/- 2,3 ?ieai.

Aeey i?iaaaeaiiy e?eoaaiiy an? oai?? aoee ?iciiae?eai? ia 4 a?oie ii 25
iaoe??io?a a eiaei?e. Oai?? ia?oi? a?oie io?eioaaee aaciao oa?ai?th, yea
aeeth/aea : a?iioie?oeee, ioeie?oeee, i?ioecaiaeuei? oa
aioeaaeoa??aeuei? caniae. Oai?ei ae?oai? a?oie, ii?yae ?c aaciaith
oa?ai??th, i?ecia/aee o?ieanai; o?aouei? – ?ioiae; /aoaa?oi? a?oie –
ii?aeiaiiy o?ieanaio oa ?ioiaeo ia oe? aaciai? oa?ai??.

I?e aea/aii? aeoeaiino? nenoaie no?oaeoaioo eaaaiue aeei?enoiaoaaee
iiaeeo?eiaaiee iaie ( ?aoe?iiae?caoi?nueea i?iiiceoe?y ? 14/2351 ?OAeIA)
iaoiae A?eueaaeuei?-Ethaia?a ( Aa?acianueeee A.A., Ai?/aeia A.TH. 1982).

Eiioeaio?aoe?th e?cioeeio ne?iaaoee e?ia? oa a?iio?aeueiiai nae?aoo
aecia/aee ca iaoiaeii I.A.Aooa??ia ( 1986).

?ioiioaiioeioaaiiy noaiiioeyoe?e O- ? A-e?ioioeeo?a i?iaiaeeee iaoiaeii
iai?yii? ?ioiioethi?enoeaioe??, c aeei?enoaiiyi iiiieeiiaeueieo aioeo?e
aei CD3, CD4, CD8, CD56 o??ie “Sigma” oa a?o/eciyieo na??e ?II 3, ?II
24, ?II 47. Aeae?eaiiy e?ioioeeo?a c ia?eoa?e/ii? e?ia? i?iaiaeeee ca
iaoiaeii E.A.Oaeoaoea ? A.O.Aaaee?ia (1973).

??ai? ?ioiiaeiaoe?i?a eean?a A, I, G, D, E oa sIgA aecia/aee iaoiaeii
?ioiioa?iaioiiai aiae?co ia aia?ao? Stat-Fax 300 Micro Strip Reader
(NOA) oa iiiiniaoeeo?/ieo ne?iaaoie o??ie Sigma.

Io?eiai? aeai? ii?aoeueiaoaaee iaoiaeii aa??aoe?eii? noaoenoeee ca
aeiiiiiaith aeaeo?iiieo oaaeeoeue Exell oa eiii’thoa?iiai caaacia/aiiy
“Statistika for Windovs”.

?ACOEUeOAOE AeINE?AeAEAIIss OA ?O IAAIAI?AIIss.

I?iaaaeaieie aeine?aeaeaiiyie anoaiiaeaii, ui o oai?eo ia OIA aei
e?eoaaiiy aeyaeaii a??ia?aeia (?0,05), ?gD-ia
30 ia/ie (?>0,05), a ?gA-ia 66 ia/ie (?I?aei. aei ae?oeo 16/02-99 ?. Oi?iao 30x42 1/4 Iai?? ae?oe ?1 Niin?a ae?oeo ??cia?ao?/iee. Oiiai. ae?oe. a?e. 1/4 Oe?aae 100. Cai.152. i. ?aaii-O?aie?anuee, aoe.Iacaeaaeiino?, 46, II “N?iee”. PAGE 20

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