OE?A?INUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO

AI?AeAI?IEIA?? OA ?IOAEOe?EIEO OAI?IA IIC

OE?A?IE ?i. E.A.A?IIAOAANUeEIAI

AAEAeAE IAOAE?ss AIEIAeEIE??AIA

OAeE 616.9-211/.232-036.11-053.2/.5-07-08

EE?I?EI-?IOIIEIA?*IA IAA?OIOOAAIIss AeEOA?AIOe?EIAAIEO IAOIAe?A
?AAA?E?OAOe?? Ae?OAE C *ANOEIE ?ANI??AOI?IEIE ?IOAEOe?ssIE

14.01.13 — ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Ee?anuee?e Iaaee/i?e Aeaaeai?? I?neyaeeieiiii?
Ina?oe

?i. I.E.Ooieea

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

*a?ieoiaa Ethaeieea ?aai?aia,

caa. eaoaae?ith aeeoy/eo
?ioaeoe?eieo oai?ia

Ee?anueei? Iaaee/ii? Aeaaeai??
I?neyaeeieiiii?

Ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,

Aieiaiee aeeoy/ee ?ioiieia IIC
Oe?a?ie

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe

?oaeaiei Aioii?ia Ieaen??aia,

noa?oee iaoeiaee ni?a?ia?oiee
Ee?anueeiai

iaoeiai-aeine?aeiiai ?inoeoooo
ai?aeai?ieia?? oa

?ioaeoe?eieo oai?ia ?i.
E.A.A?iiaoaanueeiai

IIC Oe?a?ie,

Aieiaiee ?ioaeoe?ii?no IIC Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?

O??oeiaa E?y Ieaen??aia,

eaoaae?a aeeoy/eo ?ioaeoe?eieo
oai?ia

Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo

?i. I.I.Aiaiiieueoey

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

?i. Ae.Aaeeoeueeiai

Caoeno a?aeaoaeaoueny «28» aeiaoiy 1999 ?ieo i 10-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.614.01 Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A.A?iiaoaanueeiai (252015, i.Ee?a, aoe. N?/iaaiai iianoaiiy, 23).
C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A.A?iiaoaanueeiai (252015, i.Ee?a, aoe. N?/iaaiai iianoaiiy, 23).

Aaoi?aoa?ao ?ic?neaiee » 25 » aa?aniy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
A.Ae.Aiae

aeieoi? iaaee/ieo iaoe

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie.

Ia aeaiee /an i?iaeaia /anoi? caoai?thaaiino? o ae?oae , na?aae
yei? ia?oa i?noea iin?aeathoue oai?iae i?aai?a aeeoaiiy, caeeoa?oueny
aeineoue aeooaeueiith: aino?? ?ani??aoi?i? ?ioaeoe?? iathoue iaea?eueo
ieoiio aaao a no?oeoo?? caoai?thaaiino? ae?oae ? a cia/iiio nooiai?
aecia/athoue noai caei?ia’y ae?oae ? iieacieee aeeoy/i?
nia?oiino? (Aa?aaeiee A.A., 1996; Iicaeaanueeee A.O., 1996).

A oaia??oi?e /an iaoiii?oic aino?eo ?ani??aoi?ieo caoai?thaaiue
ia? oaiaeaioe?th aei a?eueo aaaeeiai, oneeaaeiaiiai ia?aa?ao oa
ca?eueoaiiy eiioeiaaioo /anoi oai??th/eo aino?eie ?ani??aoi?ieie
?ioaeoe?yie ae?oae (Aaaoo?ia I.?., 1996; Iicaeaanueeee A.O., 1996;
AEaeacieeiaa A.O.,1997, Pechere J-C., 1995).

Iacaaaeath/e ia aaeeeo oaaao aei i?iaeaie /anoi? caoai?thaaiino?
ae?oae ia ?ani??aoi?i? ?ioaeoe??, e?euee?noue oai??th/eo ia ia?
oaiaeaioe?? aei cieaeaiiy. Iayai?noue eiioeiaaioa ae?oae, eio?? iiaoi?ii
ia?aiinyoue ?ani??aoi?i? ?ioaeoe??, ?iiae? uii?ny/ii, iaoiiaeth?
oi?ioaaiiy ina?aaee?a ?ioaeoe?? a aeeoy/eo eieaeoeaao, ui i?aeo?eio?
oeae aenieee ??aaiue caoai?thaaiino? (E.I.Neiaiaeyi ? ni?aao., 1993).

Oe?iea aeei?enoaiiy i?aia?ao?a c ?ioiiiiaeoethth/ith ae??th ia
caaaeaee ia? iaa?oioiaaia canoinoaaiiy ? ia caaaeaee ei?enia aeey
i?ae?inoath/iai iieie?iiy (A.Otheuea?aoo, Ae.Iaeueia, 1996 ). Oiio
aeooaeueiith ? ?ic?iaea aeeoa?aioe?eiaaieo i?aeoiae?a aei iaoiae?a
?aaa?e?oaoe?? ae?oae c /anoeie ?ani??aoi?ieie ?ioaeoe?yie ? iieacaiue
aei i?ecia/aiiy ?ioiiei?aaoth/i? oa?ai?? ia i?aenoaa? aeyaeaieo
ee?i?/ieo oa ?ioiieia?/ieo iniaeeainoae.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie.

Aeena?oaoe?eia ?iaioa ? o?aaiaioii Aea?aeaaii? eiieo?nii?
iaoeiai-aeine?aeieoeueei? ?iaioe ia oaio: «?ic?iaea aoaeoeaieo iaoiae?a
i?io?eaeoeee ?aoeeaeea?a aa?iaoe/ii? ?ioaeoe?? o ae?oae»,
?aa?no?aoe?eiee iiia? 019EI14692, oeo? E — 57.7, caoaa?aeaeaii? iaeacii
IIC Oe?a?ie a?ae 20.05. 1997?. ? 101.

Iaoa aeine?aeaeaiiy.

?ic?iaeoe aeeoa?aioe?eiaai? i?aeoiaee aei e?eoaaiiy ae?oae c
/anoeie ?ani??aoi?ieie ?ioaeoe?yie ia i?aenoaa? aeyaeaieo o ieo
ee?i?ei-?ioiieia?/ieo iniaeeainoae, ui ni?eyoeia cieaeaiith /anoioe
?ani??aoi?ieo ?ioaeoe?e.

Caaea/? aeine?aeaeaiiy.

Aecia/eoe iniaeeaino? ee?i?/ii? oa?aeoa?enoeee ae?oae c /anoeie
?ani??aoi?ieie ?ioaeoe?yie.

Aeine?aeeoe ?ioiieia?/i? iniaeeaino? a caeaaeiino? a?ae ee?i?/ii?
oa?aeoa?enoeee ae?oae c /anoeie ?ani??aoi?ieie ?ioaeoe?yie.

Aecia/eoe ee?i?ei-?ioiieia?/i? iieacaiiy aeey i?ecia/aiiy
?ineeiiiai aaeaioiaaia (Ao?iaoeay io?io?ia) ? oaa?eiiiai iioiaeaeaiiy
(Oeiinoeioe?i) ?ioiiiiaeoeyoi?a o ae?oae c /anoeie ?ani??aoi?ieie
?ioaeoe?yie.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a.

Aia?oa aeae?eaia oa iienaia a?oia ae?oae, o yeeo /ano?
?ani??aoi?i? ?ioaeoe?? ii?aeiothoueny c iiaoi?ieie i?iyaaie
?aoeeaeeaoth/i? HSV-?ioaeoe??.

Iienai? iniaeeaino? ?ioi?oaoa i?e ii?aeiaii? /anoeo ?ani??aoi?ieo
?ioaeoe?e ? ?aoeeaeeaoth/i? HSV-?ioaeoe?? o ae?oae, yeeie ? a?eueoa
/anoioa cieaeaiiy CD4+T-e?ioioeeo?a.

I?iaaaeaia eiiieaenia ianoaaeaiiy a?oie ae?oae c /anoeie
?ani??aoi?ieie ?ioaeoe?yie (caaaeueiee aiae?c e?ia? c eaeeioeeoa?iith
oi?ioeith, a??onieia?/ia ianoaaeaiiy iace?a c ?ioiaeioee ? iina,
aeine?aeaeaiiy i?e?ioei?e ?ioiaeioee oa eeoa/ieea, aeine?aeaeaiiy e?ia?
ia HSV-?ioaeoe?th, aea/aiiy ooieoe?iiaeueii? aeoeaiino? iaeo?io?e?a —
INO-oano, aecia/aiiy noaiiioeyoe?e e?ioioeeo?a c aeei?enoaiiyi
iiiieeiiaeueieo aioeo?e oeyoii aeaieieuei?iaiai oaiioeioaaiiy ia
i?ioi/iiio oeeoioeoi??iao?? FACScan, ?ioiiaeiaoe?ie e?ia?, a oaeiae
niaoeeo?/i? oeo?e aioeo?e aei aaeoeeiaeueieo aioeaai?a ei??, aeeooa???
oa i?aaoeth ca aeiiiiiaith ?IAA) iieacaei, ui ae?oe, ye? ??aeei
oai??thoue ia ?ani??aoi?i? ?ioaeoe?? ? ae?oe, ye? /anoi oai??thoue oeeie
caoai?thaaiiyie, iathoue ci?iaiei oi/a a iaeei c aea/a?ieo ?ioiieia?/ieo
iieaciee?a.

Anoaiiaeaii, ui a a?oi? ae?oae c ai?ciaeaie ?ani??aoi?ii?
caoai?thaaiino? 6-12 ?ac?a ia ??e, a ii??aiyii? c ae?oueie, ye?
oai??thoue ia ?ani??aoi?i? ?ioaeoe?? iaioa 5 ?ac?a ia ??e, a??ia?aeii
/ano?oa aoee cieaeai? oae? iieacieee: CD3+ O-e?ioioeeoe,
CD4+O-e?ioioeeoe, CD8+O-e?ioioeeoe.

Aecia/ai? ee?i?ei-?ioiieia?/i? iieacaiiy aei i?ecia/aiiy
?ineeiiiai aaeaioiaaio (Ao?iaoea? io?io?ii?) oa oaa?eiiiai iioiaeaeaiiy
(Oeiinoeioe?i) ?ioiiiiaeoeyoi?a o ae?oae c /anoeie ?ani??aoi?ieie
?ioaeoe?yie.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

Aecia/aii, ui aeey aeyaeaiiy ee?i?/iiai aa??aioo ia?aa?ao /anoeo
?ani??aoi?ieo ?ioaeoe?e o ae?oae, iaiao?aeii ?aoaeueii cae?aoe aeai?
uiaei eiaeiiai ai?ciaea A?A?, aea?aieia?/iee aiaiiac oa noiooi? i?iyae
HSV-?ioaeoe??.

Iaa?oioiaaii, ui ?ioiieia?/ia ianoaaeaiiy ae?oae c /anoeie
(6-12 ?ac?a ia ??e) ?ani??aoi?ieeie ?ioaeoe?yie, c canoinoaaiiyi
iaoiaea i?ioi/ii? oeeoiiao???, iaiao?aeii eeoa o aeiaaeeo ii?aeiaiiy
/anoeo ?ani??aoi?ieo ?ioaeoe?e oa ee?i?/ieo i?iya?a ?aoeeaeeaoth/i?
HSV-?ioaeoe?? o aeaeyae? ai?ciae?a HSL, HSN ?/aai aooiciiai noiiaoeoa.

Aeiaaaeaia iiaeeea?noue aeei?enoaiiy an?i ae?oyi 5-14 — ??/iiai
a?eo c /anoeie (6-12 ?ac?a ia ??e) ?ani??aoi?ieie ?ioaeoe?yie, eo?na
ianoieee Ao?iaoea? io?io?ii? a aa?ani?-aeiaoi? ( ii 1 e?aie?/??e
aeeooy o 2 ?ace ia aeaiue — 14 aei?a).

Iaa?oioiaai? oa ?ic?iaeai? i?aeoe/i? ?aeiiaiaeaoe?? aei
i?ecia/aiiy oei?/ieo i?aia?ao?a, ia i?eeeaae? Oeiinoeioe?ia, yeeie
iiaeooue aooe: ii?aeiaiiy /anoeo ?ani??aoi?ieo ?ioaeoe?e oa /anoeo
i?iya?a HSV-?ioaeoe??, cieaeaiiy CD4+ O — e?ioioeeo?a 700/ ii3 ?
ieae/a.

Iieacaii, ui ae?oyi c aea?a?/iith eiinoeoooe??th oa c
iiaoi?ieie ai?ciaeaie iano?oeoeaiiai a?iio?oo iaiao?aeii
ianoaaeaiiy ooieoe?? aeeoaiiy, eiinoeueoaoe?y aea?aieiaa aeey ae??oaiiy
ieoaiiy uiaei ae?aaiica a?iio?aeueii? anoie, ca?aeii i?aeia?iaeiiai
eiinainona oa i?ecia/aiiy aacenii? oa?ai??.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo.

Io?eiai? ?acoeueoaoe iiaeooue aooe aeei?enoai? i?e e?eoaaii?
ae?oae c /anoeie ?ani??aoi?ieie ?ioaeoe?yie. Iaoiaeeea e?eoaaiiy oaeiai
eiioeiaaioo ae?oae, c aeeth/aiiyi eo?no ianoieee Ao?iaoea? io?io?ii? oa
Oeiinoeioe?io ( c o?aooaaiiyi cai?iiiiiaaieo iieacaiue aei
i?ecia/aiiy), ai?iaaaeaeaia ia aac? eiinoeueoaoeaii-ae?aaiinoe/iiai
a?aeae?eaiiy aeeoy/i? ee?i?/ii? e?ea?i? ? 1 i. Ee?aa.

Iniaenoee aianie aeena?oaioa.

Iniaenoee aianie aaoi?a a io?eiaii? iaoeiaeo ?acoeueoao?a ?
iniiaiei, neeaaea? 90% ? iieyaa? o cai?? e?oa?aoo?e, ?? aiae?c?,
i?aeai?? oa eo?aoe?? oai?eo, caai?? iaoa??aeo aeey aiae?c?a, ?ic?iaoe?
iaoiaeeee e?eoaaiiy oa i?aai?caoe?? ??, aiae?c?, ocaaaeueiaii? oa
noaoenoe/i?e ia?iaoe? ?acoeueoao?a aeine?aeaeaiiy, oi?ioaaii? aeniiae?a,
i?aeaioiaoe? iaoeiaeo aeaieo aei ioae?eaoe??, ioi?ieaii? aeena?oaoe?eii?
?iaioe oa aaoi?aoa?aoa.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

Iniiai? iieiaeaiiy aeena?oaoe?eiiai aeine?aeaeaiiy aeeeaaeaii ia
c’?cae? ?ioiieia?a ? aea?aieia?a Oe?a?ie o Eueaia? (1996 ?.), ia ???
I?aeia?iaeiiio eiia?an? «?ioii?aaa?e?oaoe?y ? ?aaa?e?oaoe?y a
iaaeeoeei?», ui a?aeaoany a o?aai? 1997 ?ieo a Aeeaeo?
(?c?a?eue), ia IV ?ioa?iaoe?iiaeueiiio neiiic?oi? c ee?i?/ii?
?ioiieia?? a Ainoa?aeai? ( eeiaiue 1997 ?., 1 aeiiia?aeue), ia
neiiic?oi? » Iia? aniaeoe e?eoaaiiy ia?aeiiiai oa aoi?eiiiai
?ioiiaeao?oeeoo » a Ee?a? (aeiaoaiue 1997 ?.).

Ioae?eaoe??.

Iniiai? iieiaeaiiy aeena?oaoe?eiiai aeine?aeaeaiiy aeeeaaeai? a
aeaa’yoe iaoeiaeo i?aoeyo, a oiio /ene? 3-o iaoeiaeo noaooyo, ye?
iioae?eiaai? o oaoiaeo aeaeaiiyo, ui aecia/ai? AAEii o yeino? oaeeo, aea
iiaeooue ioae?eoaaoenue iaoa??aee eaiaeeaeaonueeeo ? aeieoi?nueeeo
aeena?oaoe?e.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 120
noi??ieao ae?oeiaaiiai oaenoo oa neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo aeine?aeaeaiue, iaaiai?aiiy
iaea?aeaieo ?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
e?oa?aoo?e, yeee i?noeoue 178 e?oa?aoo?ieo aeaea?ae.

?iaioa ?ethno?iaaia 26 oaaeeoeyie oa 11 ?enoieaie.

INIIAIEE CI?NO ?IAIOE

O anooi? aeena?oaoe?eii? ?iaioe iaa?oioiao?oueny aea?? ?
aeooaeuei?noue oaie aeine?aeaeaiiy, aecia/athoueny iaoa, caaea/?,
iaoeiaa iiaecia, i?aeoe/ia cia/aiiy ?iaioe.

A ia?oiio ?icae?e? ?icaeyaeathoueny ??ci? ee?i?/i? i?aeoiaee aei
e?eoa???a aecia/aiiy a?oie ae?oae, ye? /anoi oai??thoue ia ?ani??aoi?i?
?ioaeoe?? oa iaaaaeai? oaeoi?e, ye? ni?eythoue ?icaeoeo iiaoi?ieo
?ani??aoi?ieo caoai?thaaiue. Iieacaii, ui o?oaeiiu? ae?aaiinoeee
aeieeathoue, eiee ?ani??aoi?i? ?ioaeoe?? ia?aa?aathoue ia oii? aoii??,
aai yeiainue eiie?aoiiai aea?a?/iiai caoai?thaaiiy. Iaaaaeai? iniiai?
?nioth/? iai?yiee ?aaa?e?oaoe?? ae?oae c /anoeie ?ani??aoi?ieie
?ioaeoe?yie. Iieacaii, ui ia oaia??oi?e /an oe?iei canoiniaothoueny
i?aia?aoe Ao?iaoea? io?io?ii?, ye ?ioiiiiaeoeyoi?e, aea ia aecia/ai?
/?oe? ee?i?ei-?ioiieia?/i? e?eoa??? o oe??? a?oie ae?oae aeey ?o
canoinoaaiiy. Oaeiae a?aei?/aii, ui iaeiei c ?iciianthaeaeaieo iaoiae?a
e?eoaaiiy ? canoinoaaiiy oei?/ieo ai?iii?a, ui a aeeoy/iio a?oe? ia?
aooe o?eueee ii iniaeeaei iieacaiiyi. Aea oe? iieacaiiy ia
eiie?aoeciaai?.

A ae?oaiio ?icae?e? aeena?oaoe?? iaaiai?ththoueny iaoa??aee oa
iaoiaee aeine?aeaeaiiy. Aeey ae??oaiiy iinoaaeaieo caaaeaiue i?iaaaeaii
ianoaaeaiiy 100 ae?oae, ye? /anoi oai??thoue ia ?ani??aoi?i? ?ioaeoe??
a?eii a?ae 5 aei 14 ?ie?a. Oaeee a?eiaee ?ioa?aae aoa ia?ai naia oiio,
ui /ano? ai?ciaee ?ani??aoi?ieo ?ioaeoe?e o ae?oae aei i’yoe??/iiai
a?eo iiaeooue aooe iiyniai? o?c?ieia?/iei o?aiceoi?iei ?ioiiaeao?oeeoii.
*ano? ai?ciaee oeeo ?ioaeoe?e i?ney 5 ?ie?a i?eiooothoue e?ea??a ooeaoe
?o i?e/eio oeyoii aeine?aeaeaiiy ?ioiiiai noaoono.

On? ae?oe aoee ?icae?eai? ia aea? a?oie : a ia?o?e a?oi? —
iniiai?e — aoee ae?oe ui oai??ee ia ?ani??aoi?i? ?ioaeoe?? 6 -12 ?ac?a
ia ??e (a na?aaeiueiio 9,3 ?ace), ae?oao a?oio — ii??aiyiiy — neeaaeaee
ae?oe, eio?? iaee aei 5 ai?ciae?a ?ani??aoi?ieo ?ioaeoe?e ia ??e (a
na?aaeiueiio 3,8 ?ace). Na?aae ae?oae ia?oi? a?oie (50 in?a) aoei 24
ae?a/eiee oa 26 oeii/ee?a, na?aaei?i a?eii 7,3 ?ie?a. A ae?oa?e
a?oii? (50 in?a) aoei 23 ae?a/eiee oa 27 oeii/ee?a, na?aaei?e a?e
ae?oae a a?oii? — 7 ?ie?a.

Aoei i?iaaaeaia aeeiai?/ia, aaaaoi?aciaa, i?ieiiaiaaia
caaaeueiiee?i?/ia ianoaaeaiiy ae?oae. Aea/aiiy iieaciee?a ?ioi?oaoo,
i?e?ioei?e c?aa oa eeoa/ieea, a??onieia?/ia aeine?aeaeaiiy iace?a c
iiniaeo oiae?a oa ieaaeaeee?a i?iaiaeeeinue a ia??iae? ee?i?/ii? ?ai?n??
a?ae iaeiiai aei /ioe?ueio ?ac?a i?ioyaii o?ueio ?ie?a niinoa?aaeaiiy.

?ioiieia?/ia ianoaaeaiiy: 1.I?ioi/ia oeeoiiao??y noaiiioeyoe?e
e?ioioeeo?a. Aeei?enoiaoaaeanue na?aeiio?eiaia aaia??i?ciaaia aaiicia
e?ia (iaeneiaeueii ?? caa??aaee aei i?iaaaeaiiy oanoo ia a?eueo, ye 6
aiaeei). Aeaieieuei?iaa oaiioeioaaiiy ia i?ioi/iiio oeeoioeoiiao??
FACScan (Becton Dickinson) i?iaiaeeeinue i?ney e?c?na a??o?ioeeo?a
e?ia?, a eio??e aoee iii?/ai? noaiiioeyoe?? e?ioioeeo?a ca aeiiiiiaith
iiiieeiiaeueieo aioeo?e o??ie Aanton Dickinson Simultest IMK —
Lymphocyte, a eio?ee aoiaeyoue aioeo?ea aeey aeyaeaiiy ND45/CD14
(Leucogate), IgG1/IgG2 (Control), CD3/CD19, CD3/CD4, CD3/CD8,
CD3/CD16+CD56. Aiae?c on?o e?ioioeeoa?ieo noaiiioeyoe?e i?iaiaeeee c
aeei?enoaiiyi i?ioi/iiai oeeoioeoiiao?a FACScan oa c canoinoaaiiyi
eiii’thoa?ieo i?ia?ai SimulSET software oa FACScan (an? Aanton
Dickinson). ?acoeueoaoe aecia/aee i?aaeeueieie oa ca?aoiaoaaee, eiee
noia O+A+NK e?ioioeeo?a aoea o iaaeao 90 — 110%. Io?eiai? ?acoeueoaoe
ii??aithaaeenue c a?eiaeie ii?iaie — i?aaenoaaeaieie o??iith Becton
Dickinson ( I. Hannet et al., 1992), ine?eueee aeei?enoiaoaaeinue
iaeaaeiaiiy, iaiae? iiiieeiiaeueieo aioeo?e oa iaoiaeeea, cai?iiiiiaai?
oe??th o??iith.

2. Oeeoioiene/ia aeoeai?noue iaoo?aeueieo e?ea?ieo ee?oei aecia/aeanue c
aeei?enoaiiyi oeeoioiene/iiai iaoiaeo ii ca?eueiaiith Eu c
ee?oei-i?oaiae E-562 (Alomberg et al., 1986).

3. ?ioiiaeiaoe?ie IgA, IgM, IgG a ne?iaaooe? e?ia? aecia/aee ca
aeiiiiiaith aioene?iaaoie ?inoeoooo aaeoeei ? ne?iaaoie ?i.Ia/ieeiaa
iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a aae? iaoiaeii Mancini et. al.
(1965).

4. ??aaiue IgE a ne?iaaooe? e?ia? ae?oae aecia/aee ?ioiioa?iaioiei
iaoiaeii c aeei?enoaiiyi oano-nenoaie o??ie Hoffmann-La Roche.

5. Aecia/aeenue oaeiae niaoeeo?/i? aioeo?ea aei aaeoeeiaeueieo aioeaai?a
ei?? , aeeooa??? oa i?aaoeth ca aeiiiiiaith ?IAA.

6. Ooieoe?iiaeueia aeoeai?noue iaeo?io?e?a ia?aoa?e/ii? e?ia?
aecia/aeanue ca ?aaeoe??th a?aeiiaeaiiy i?o?ineiueiai oao?acie?y —
INO-oano a i?e?iiiaeeoeeaoe?? c aeei?enoaiiyi eai?ey?ii? e?ia?
Ai?ae??iei N.I. (1983). Aeey aecia/aiiy ?aca?aieo iiaeeeainoae
oaaioeeoa?ii? nenoaie e?ia? ?aaeoe?th noaaeee a aeaio aa??aioao —
niiioaiiee oa noeioeueiaaiee INO — oano c ianooiiei ?ic?aooieii
iieacieea oaaioeeoa?iiai ?aca?ao (Oiaeaa A.E. e niaao., 1979). A yeino?
noeioeyoi?a aeei?enoiaoaaee e?iiiie?naoa?eae E. coli I 55,
aeae?eaiee ca iaoiaeii Aanoaey, a eiioeaio?aoe?? 20 iea/ie. I?aia?ao
io?eiaii a a?aeae?e? a?io?i?? i?e?ii?aai?ci?a (caa. i?io.
?.ss.Caoa?iaa) ?inoeoooa i?e?ia?ieia?? oa a??onieia?? AI Oe?a?ie.

Aeey ae?aaiinoeee ?ani??aoi?ieo a??onieo ?ioaeoe?e
canoiniaoaaee iaoiae ?ioiioethi?anoeaioe?? (iinoa/aeueiee niaoeeo?/ii?
i?ioea??onii? ne?iaaoee — N.- I?oa?ao?anueeee ?inoeooo a?eio, ?in?y).

Aeine?aeaeaiyy e?ia? ia HSV- ?ioaeoe?th ca aeiiiiiaith
?ioiioa?iaioiiai oanoa (aioe-HSV- ? / ?? A/ A o??ie Hoffmann-La Roche
— ?ioiioa?iaioiee oano aeey iai?yiiai iaeii/aniiai aecia/aiiy aioeo?e
ethaeeie aei a??ono aa?iano cae/aeiiai ? oa ??) i?iaiaeeeinue aea??eiai.

Aaeoa??ieia?/i? aeine?aeaeaiiy i?e?ia?ioeaiic?a eeoa/ieea oa
c?ao i?iaiaeeee ye?niei oa e?euee?niei iaoiaeaie o an?o ae?oae oe???
a?oie a i?ae?aoeeaeeaiee ia??iae ca caaaeueiii?eeiyoeie iaoiaeeeaie
(Ciaiaineee A.A., 1986). Ai?no i?e?ii?aai?ci?a aecia/aee ca e?euee?noth
eieii??ooai?thth/eo iaeeieoeue (EOI) a 1 a aeine?aeaeoaaiiai iaoa??aeo.

Noaoenoe/iee aiae?c. Io?eiai? ?acoeueoaoe ii?aoeueiaai? ia
eaeueeoeyoi?? IE-54, iaoaiaoe/i? ?ic?aooiee, noaoenoe/iee ?
ei?aeyoe?eiee aiae?c i?iaiaeeeenue ia ia?niiaeueiiio eiiiuethoa??
(Pentium® 513-3657) c aeei?enoaiiyi iaeaoo i?ia?ai
«Statgraphics». ??cieoe? iieaciee?a a a?oiao aoee ?ic?aoiaai? ca
aeiiiiiaith iaia?aiao?e/ieo noaoenoe/ieo oano?a Wilcoxon oa
Wilcoxon-Mann-Whitney (A.A. Aoaea?., 1978). Noaoenoe/io a??ia?aeio
a?aei?ii?noue i?ae a?oiaie oaeiae aiae?coaaee ca aeiiiiiaith iaoiaea c2.
??cieoe? iieaciee?a aaaaeaeeny a??ia?aeieie i?e cia/aii? p<0,05; oiaoi o aeiaaeeao, eiee ?iia??i?noue a?aei?iiinoae aoea a?eueo i?ae 95%. Aeey ei?aeyoe?eiiai aiae?co canoiniaoaaany ?aiaiaee iaoiae Candall. A o?aoueiio ?icae?e? iaaaaeai? aeai? ee?i?ei-eaai?aoi?iiai ianoaaeaiiy ae?oae c /anoeie ?ani??aoi?ieie ?ioaeoe?yie. Aeyaeaii, ui o ae?oae c /anoeie ?ani??aoi?ieie ?ioaeoe?yie (6-12 ai?ciae?a ia ??e), a ia??iae i?ae ai?ciaeaie caoai?thaaiue, c aa?oi?o aeeoaeueieo oeyo?a iaoiaeii ?ioiioethi?anoeaioe?? o 57% ianoaaeaieo (n=40) aeae?eythoueny ?ani??aoi?i? a??one: ia?aa?eia - 26%, aaeaiia??one - 21%, ?ani??aoi?ii-neioeeo?aeuei? -13%, a?eia - 4%, anioe?aoe?? a??on?a - 34% ( ?en 1.). Aaeoa??aeueia oei?a aeae?eaia c ?ioiaeioee o 36% ianoaaeaieo ae?oae (n=38) c ieo b-aaiie?oe/iee no?aioieie a e?eueeino?, ui ia?aaeuo? 103 EOI/ie iaoa??aeo o 13,2% aeiaaee?a, cieioaaee noao?eieie -o 28,9%, ?o ii?aeiaiiy - o 5,3% aeiaaee?a. A a?oi? ii??aiyiiy ?ani??aoi?i? a??one aeyaeai? o 15% ianoaaeaieo, aaeoa??aeueia oei?a aeae?eaia o 6%. Ae?oe iniiaii? a?oie iaa?oue ciai? i?eaa?oaee aei naaa a?eueoo oaaao, ine?eueee an? aiie iaee i?iyae ?ioieneeaoe??: ae?ae?, c oa?aie i?ae i/eia, a?eueo?noue ieya?, ooaei?eya?, /anoi nea?aeeeenue ia cia/io aoiieai?noue, cieaeaiiy aiaoeoo. *a?ac /ano? oai?iae, aiie ia iiaee a?aea?aeoaaoe aeeonaaeie, iaee aaaaoi i?iione?a caiyoue a oeie?. O 30% ae?oae niinoa??aaeanue a?ia?ieac?y ieaaeaeee?a. ?aaeoe?y caaeiueioeeieo oa/aai i?aeuaeaiieo e?ioaoe/ieo aoce?a aeyaeaia o 88% ae?oae oe??? a?oie. O 45% ae?oae iaee i?noea o?aoa?oe oa a?iio?oe. Na?aaeiy o?eaae?noue iaeiiai ai?ciaea ?ani??aoi?iiai caoai?thaaiiy a iniiai?e a?oi? neeaaeaea 2,5 oeaeiy. A oie /an, ye a a?oi? ii??aiyiiy i?iyae ?ioieneeaoe?? aoee o?eueee o 5 ae?oae, a?ia?ieac?y ieaaeaeee?a niinoa??aaeanue o 14% ae?oae, ?aaeoe?y caaeiueioeeieo oa/aai i?aeuaeaiieo e?ioaoe/ieo aoce?a aeyaeaia o 20%, o?aoa?oe ? a?iio?oe aoee iiiaeeiie?, a o?eaae?noue iaeiiai ai?ciaea ?ani??aoi?iiai caoai?thaaiiy, a na?aaeiueiio, ia ia?aaeuoaaea 1 oeaeiy. I?ae /an ianoaaeaiiy c'yniaaii, ui o 26% ae?oae iniiaii? a?oie ?ani??aoi?i? ?ioaeoe?? ia?aa?aathoue ia oii? aea?a??, o 30% - noi?iaiaeaeothoueny ?aoeeaeeaaie HSV-?ioaeoe??, 24% ae?oae iathoue aea?a?/i? i?iyae a ii?aeiaii? c ?aoeeaeeaoth/ith HSV-?ioaeoe??th, ? o?eueee 20% ae?oae - eeoa ?ani??aoi?i? ?ioaeoe??. A a?oi? ii??aiyiiy i?iyae HSV-?ioaeoe?? aoee a aiaiiac? o 16% ae?oae, a aea?a?/i? ?aaeoe?? iaee 10% ae?oae. I?iaaaeaia aeine?aeaeaiiy noaiiioeyoe?eiiai neeaaeo e?ioioeeo?a iieacaei, ui na?aae ianoaaeaieo ae?oae iaia? aeiaeii?, eio?a ia iaea a ci?iaiei oi/a a iaeei c aeine?aeaeaieo iieaciee?a. A a?oi? ae?oae c /anoioith ?ani??aoi?ii? caoai?thaaiino? 6-12 ai?ciae?a ia ??e, a ii??aiyii? c ae?oueie, ye? oai??thoue ia ?ani??aoi?i? ?ioaeoe?? iaioa 5 ?ac?a ia ??e, a??ia?aeii /ano?oa niinoa??aa?oueny cieaeaiiy CD3+O-ee?oei, CD4+O-ee?oei, CD8+O-ee?oei (?en. 2). Iaie oaeiae aoei aeyaeaii, ui o ae?oae iniiaii? a?oie, o yeeo /ano? ?ani??aoi?i? ?ioaeoe?? noi?iaiaeaeoaaeenue ee?i?/ieie i?iyaaie ?aoeeaeeaoth/i? HSV-?ioaeoe??, ye? iaee iioe?aiee oa?aeoa? oa no?eeee, iaeaea aacia?a?aiee ia?aa?a, iniaeea?noth ?ioiiiai noaoona ? ae?aaiinoiaaia o 61 a?aenioeo aeiaaee?a CD4+O-e?ioioeeoiiai?y (CD4+O-e?ioioeeoe < 700 /ii3). ?

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