Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao

NAIEIAA ??eia
Aai?a??aia

OAeE
616.516.5-053-08-039.57:612.017

EE?I?EI — ?IOIIEIA?*IA OA?AEOA?ENOEEA Ae?OAE

C ??CIEIE OI?IAIE AOII?*IIAI AeA?IAOEOO OA

?O ?AAA?E?OAOe?ss A AIAOEAOI?II —
IIE?EE?I?*IEO

OIIAAO

14.01.10 —
iaae?ao??y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy
iaoeiaiai nooiaiy

eaiaeeaeaoa
iaaee/ieo iaoe

Oa?e?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioo aeeiiaii a Oa?e?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii?
ina?oe.

Iaoeiaee ea??aiee — aeieoi? iaaee/ieo iaoe , i?ioani? Eiaeaicyea
Aiaoie?e

?aaiiae/, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e aeeoy/eo
oai?ia.

Io?oe?ei? iiiiaioe — aeieoi? iaaee/ieo iaoe , i?ioani? Noea/iaa
Aaiia

?aai?aia , Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao ,

i?ioani? eaoaae?e
oaeoeueoaonueei? iaae?ao??? c iaaee/iith

aaiaoeeith

— aeieoi? iaaee/ieo iaoe, i?ioani?
Aieueoeaa Aiaoie?e

Ieeieaeiae/, ?inoeooo i?iaeai
e??ia?ieia?? oa e??iia-

aeeoeeie AII Oe?a?ie, caa?aeoaa/
a?aeae?eii.

I?ia?aeia onoaiiaa : ?inoeooo iaae?ao??? , aeooa?noaa ? a?iaeieia??
AII Oe?a?ie, a?aeae?eaiiy o?c?ieia?? ? iaoieia?? ae?oae ?aiiueiai
a?eo , i. Ee?a

Caoeno a?aeaoaeaoueny “__11_” ____eenoiiaaea______1999 ?. i
__12:00____ aiaeei?

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.64.600.04 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ( 310022, i.
Oa?e?a, i?. Eai?ia , 4 ) .

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?. Eai?ia
, 4)

Aaoi?aoa?ao ?ic?neaiee “___7____”_____aeiaoiy__________1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe , aeioeaio _________________________E.?.
Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca aeaieie Anana?oiuei? i?aai?caoe??
ioi?iie caei?iacy, a?o/eciyii? oa ca?oa?aeii? e?oa?aoo?e
aea?a?/i? caoai?thaaiiy ? iaei??th ?c i?ia?aeieo i?iaeai a
iaoieia?? aeeoy/iai a?eo ( ?.?.Aaeaaiee?i , 1986, 1991, 1998;
I.ss. Nooaeai?e?i , O.N.Nieieiaa , 1986; TH.E.Ne?eie?i , ?c ni?aaao.,
1995; I.ss.Nooaeai?e?i , ?.?.Aaeaaiee?i , 1998 ; R.S. Aakes et
al., 1993; A. Breborowicz et al.,1995 ). Aio?iiiaaiia caa?oaeiaiiy
a?inoa?e, o?aai?caoe?y, c?inoath/ee oene iani?eyoeeaeo /eiiee?a
ciai?oiueiai na?aaeiaeua ia aaeeeo e?euee?noue ae?oae (
oe?aeeea? a?aeoiaee i?iieneiaiai ae?iaieoeoaa, o?i?caoe?y
n?euenueeiai ainiiaea?noaa, iiaooo ; ia caaaeaee iaa?oioiaaia
aeei?enoaiiy e?ea?nueeeo ?a/iaei ; eiina?aaioe oa aa?aieee oa?/iai?
i?iieneiaino? ) ? aieiaiith i?e/eiith iioe?aiiy aea?a?/ieo
caoai?thaaiue. ( A.I. Iioueiie?ia , 1990 ; TH.I. Eaceie?ee , 1992 ;
TH.?. Aaeueoeuaa ?c ni?aaao.,-1995 ; I.ss.Nooaeai?e?i ?c
ni?aaao.,1998; T. David, 1997 ; A. Sampson Hiugh , 1997).

Iaea?eueo iioe?aiei na?aae aea?a?/ieo caoai?thaaiue o
oaia??oi?e /an ? aoii?/iee aea?iaoeo ( ?.?. Aaeaaiee?i, 1991).
Iae/ano?o caoai?thaaiiy oi?io?oueny o ae?oae c aiiiae??th
eiinoeoooe?? (aea?a?/iee, e?ioaoeei — a?iiieanoe/iee , ia?aiai —
a?o?eoe/iee ae?aoace ) oa niaaeeiaith aea?a?/iith noeeuei?noth
( I.?.Eaneoey ?c ni?aaao., 1991, E.?.Iiieoe?ia, 1996 ). Anoaiiaeaii,
ui ia ?icaeoie oeueiai caoai?thaaiiy iathoue aieea
iaaeeei-nioe?aeuei? ia?eiaoaeuei? /eiieee ( ?.I.Ieeeo?-ia , 1988;
A.A. Eia?einueeee , 1995; B. Bioksten , 1994 ). Iaeiie/aiee
iaoa??ae noai?ea iiaeeeaino? aeae?eeoe ee?i?/i? oi?ie
aoii?/iiai aea?iaoeoo a caeaaeiino? a?ae iniaeeainoae oe??ieo
i?iya?a oa a?eo aeeoeie — aenoaeaoeaia , a?eoaiaoicii — neaaiicii —
e?oaii?aeia , e?oaii?aeia , i?o?ea?iicia (?.?.Aaeaaiee?i , 1991;
A.O.Aeooaiueeee , 1990 ).

Iaoiaaiac ?icaeoeo aea?a?/ieo ae?aoac?a neeaaeiee ? aaaaoi
ieoaiue caeeoathoueny iaccyniaaieie. I?ia?aeiei a iaoiaaiac? AAe
caeeoa?oueny iaoai?ci ?icaeoeo , iiacycaiee c a?ia?i?iaeoeoe??th Ig
E oa oa?ai? niaaeeiaeo /eiiee?a ( ?.?.Aaeaaiee?i, 1991) .
A?ia?i?iaeoeoe?y Ig E o oai?eo ia aoii?/iee aea?iaoeo a cia/i?e
i??? iiacycaia c? ci?iaie a nenoai? ee?oeiiiai ?ioi?oaoo (??ciiai
nooiaiy aeao?oeeoo O–e?ioioeeo?a, noaiiioeyoe?? O — noi?ani??a,
ca?eueoaiiyi ?ioii?aaoeyoi?iiai ?iaeaeno ( ?.I. Oi?iiiaa , 1993).

Aea/aiiy ee?i?ei — ?ioiieia?/ieo ia?aeaeae a?ae ?aii?o
oi?i ?icaeoeo AAe / aeno-aeaoeaii? / aei i?ci?oeo /
e?oaii?aeii? , iniaeeai o ii?aeiaii? c ?ani??aoi?iei aea?aicii /
aeicaieythoue ?icoe?eoe oyaeaiiy i?i iaoiaaiac aoii?/iiai
aea?iaoeoo ? ia oe?e iniia? oaeineiiaeeoe ?aeiiaiaeaoe?? ii
oa?ai??, ye? aaea ?niothoue .

Cacycie ?iaioe c iaoeiaeie i?ia?aiaie. Aeena?oaoe?th
aeeiiaii a ?aieao iaoeiai –aeine?aeii? ?iaioe Oa?e?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe “ Ee?i?ei –
?io-iieia?/ia oa?aeoa?enoeea ae?oae c aea?a?/ieie i?iyaaie “.

( ? aea?aeaaii? ?a?no?aoe?? 0195U020622)

Iaoa ?iaioe. Ee?i?ei – ?ioiieia?/ia iaa?oiooaaiiy oa
oaeineiiaeaiiy oa?ai?? ae?oae, oai?eo ia ??ci? oi?ie aoii?/iiai
aea?iaoeoo a iie?ee?i?/ieo oiiaao.

Aieiai? caaea/? aeine?aeaeaiiy :

— aea/eoe iniaeeaino? ee?i?ei–?ioiieia?/iiai noaio ae?oae
, oai?eo ia ??ciiiai?oi? oi?ie aoii?/iiai aea?iaoeoo (
aenoaeaoeaio, i?o?ea?iicio, a?eoaiaoicii – neaaiicii – e?-oaii?aeio
oa ii?aeiaio c ?ani??aoi?iei aea?aicii) .

— aecia/eoe iieacieee O ? A — nenoai ?ioi?oaoo oa oaeoi?e
ianiaoeeo?/iiai caoenoo (oaaioeeoic, ne?iaaoeiaee eiiie?iaio oa
e?cioeei ) a caeaaeiino? a?ae ia?aa?ao aoii?/iiai aea?iaoeoo oa
eiai e?eoaaiiy .

— iaa?oiooaaoe iiaeeea?noue aeei?enoaiiy aioa?ini?aoe?? oa
?ioiiei?aeoe?? o eiiieaeniiio e?eoaaii? ae?oae , oai?eo ia
aoii?/iee aea?iaoeo.

— ?ic?iaeoe ? aecia/eoe aoaeoeai?noue ?aaa?e?oaoe?eieo
caoiae?a i?e e?eoaaii? ae?oae , oai?eo ia ??ci? oi?ie
aoii?/iiai aea?iaoeoo a aiaoeaoi?ii — iie?ee?i?/ieo oiiaao.

Iaoeiaa iiaecia. Aia?oa , ee?i?ei — ?ioiieia?/i? aeai?
aeicaieeee ie?aneeoe aieia-i? ee?i?/i? aa??aioe aoii?/iiai
aea?iaoeoo o ae?oae. Anoaiiaeaii ii?ooaiiy ooieoe?i-iaeueiiai
noaio O ? A- e?ioioeeo?a, a oaeiae ianiaoeeo?/ieo oaeoi??a
caoenoo ( oaaioeeoi-co, ne?iaaoeiaiai eiiie?iaioo oa e?cioeeio) a
ia??iae caaino?aiiy oai?iae , iniaeeai o ae?-oae c AAe ,
ii?aeiaiei c ?ani??aoi?iei aea?aicii. Ia oa?ai? aea/aieo
ee?i?ei – ?io-iieia?/ieo iieaciee?a O ? A nenoai ?ioi?oaoo
cai?iiiiiaaii iaoiaaiaoe/ii iaoiiaeaiee i?aeo?ae uiaei
e?eoaaiiy ae?oae, oai?eo ia ??ci? oi?ie aoii?/iiai aea?iaoeoo.

A ?acoeueoao? aea/aiiy aieeao ?ioiiiiaeoeyoi??a oa
aioa?ini?aaio?a ia ee?i?/iee ia- ?aa?a aoii?/iiai aea?iaoeoo
anoaiiaeaii, ui oe? caniae ni?eythoue a?aeiiaeaiith
?ioiiei-a?/ieo iieaciee?a , iie?ioothoue ee?i?/iee noai oai?eo.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. I?iaaaeaiee
ee?i?ei – ?ioiieia?/iee aiae?c niinoa?aaeaiue ??cieo ee?i?/ieo
aa??aio?a aoii?/iiai aea?iaoeoo aeicaieea aaoi?o cai?iiiioaaoe
aeioe?eueiee eiiieaen ?ioiieia?/ieo aeine?aeaeaiue i?e
aa?eo?eaoe?? ae?aaiico AAe. Oaeineiiaeaii noaio ?aaa?e?oaoe?? oai?eo
ia AAe a aiaoeaoi?ii–iie?ee?i?/ieo oiiaao. Na?aae ?aaa?e?oaoe?eieo
caoiae?a, ii?yae c o?aaeeoe?eieie, cai?iiiiiaaii ?
ai?iaaaeaeaii a i?aeoe/io ae?yeuei?noue e?ea??a – iaae?ao??a
aioa?ini?aaioe — EAA – 1 , ni?aiaaeue oa ?ioiiiiaeoeyoi? oeiiaai
, ui cia/ii i?aeaeueei ye?noue e?eoaaiiy oe??? eaoaai??? oai?eo
ae?oae.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? o oi?i?
?ioi?iaoe?eieo eeno?a o i?aeoeeo e?-eoaaeueieo caeeaae?a i?noa
Oa?eiaa ( aeeoy/? iie?ee?i?ee ?? 1, 7, 14, 15 , eiinoeueoaoea-i?e
iie?ee?i?oe? Oe?IAe?ICAeI ). Aoaeoeai?noue ai?iaaaeaeaiiy : cia/ii
ciaioeeanue /anoioa caaino?aiue AAe , ?ai?n?y iaaoea a?eueo
no?eeiai oa?aeoa?o.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii i?iaiaeeeinue
ee?i?/ia ianoa-aeaiiy oai?eo , aa?eo?eaoe?y ae?aaiico. ?ic?iaeaii
noaio iaeea?aeoaeueiiai ?ioiieia?/iiai ianoaaeaiiy. Iniaenoi
aeeiiaii iiiaae 60% eaai?aoi?ieo aeine?aeaeaiue, iiai?noth
naiino?eii i?iaiaeeeinue e?eoaaiiy ae?oae c aeei?enoaiiyi
aioa?ini?aaio?a oa eioiiiiaeoeyoi??a. Naiino?eii i?iaiae?ciaai?
iaoa??aee aeine?aeaeaiue, ?o noaoenoe/ia ia?iaea, iaienai? an?
?icae?ee aeena?oaoe??, noi?ioeueiaai? aeniiaee oa i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?iaioe. Iniiai? iieiaeaiiy ?iaioe aoee iaaiai?ai? ia
ni?eueiiio can?aeaii? eaoaae? iaae?ao??? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? Oa?e?anueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a, iaoeiai – aeine?aeiiai ?inoeoooo ioi?iie
ae?oae oa i?ae-e?oe?a ( 1998?.), ia nai?ia?? “ Ni?aaioe oa ?o
aeei?enoaiiy a iaae?ao??? ” ( Iaaeeoeeia oa aeieia?y, 1996) ,
iaoeiai — i?aeoe/ieo eiioa?aioe?yo : “Aeooaeuei? i?iaeaie
aeeoy/i? oa i?aee?oeiai? aiaeie?eiieia?? “ ( Oa?e?a, 1995) ,
“Aeooaeuei? ieoaiiy caei?iacy ae?oae oe?eue-iiai oa
i?aee?oeiaiai a?eo “ ( Oa?e?a, 1996, 1997) , “ Oa?/oaaiiy caei?iai?
oa oai?i? aeeoeie “ ( Oa?e?a, 1999), Oa?e?anuee?e i?nuee?e iaoeiai
– i?aeoe/i?e eiioa?aioe?? iaae?ao??a (1999) .

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 10
?ia?o, c yeeo 4 — o iaoeiaeo aeo?iaeao ( a o. /. 2 naiino?ei?)
, 2 — o ca??ieeao iaoeiaeo ?ia?o, 4 — o iaoa??aeao eiioa?aioe?e
.

No?oeoo?a oa ianya ?iaioe . Aeena?oaoe?th aeeeaaeaii
ia 168 noi??ieao ae?oeiaaiiai oaenoo; aiia neeaaea?oueny ?c
anooio, iaeyaeo e?oa?aoo?e, /ioe?ueio aeaa ?acoeueoao?a aeanieo
aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e. Aeena?oaoe?y i?noeoue 30 oaaeeoeue , 6 iaethie?a, 2
aeoyae c ?noi??e oai?ia ( ui neeaaea? 42 noi??iee). A?ae?ia?ao?y
aeeth/a? 237 aeaea?ae a?o/eciyieo oa ca?oa?aeieo aaoi??a ( ui
neeaaea? 19 noi??iie ).

CI?NO
?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. I?ae iaoei
niinoa?aaeaiiyi a 1 i?nuee?e aeeoy/?e iie?ee?i?oe? oa
aea?aieia?/iiio a?aeae?eaii? iaeanii? aeeoy/i? ee?i?/ii? e?ea?i?
?1 i?noa Oa?eiaa ia?aaoaaei 114 ae?oae o a?oe? a?ae 2
aei 14 ?ie?a ye? no?aaeaeaee ia aoii?/iee aea?iaoeo. C ieo
ae?a/aoie — 72 ( 63.2%) , oeii/ee?a — 42( 36.8%).

Iaoiaeii i?yiiai aieaooaaiiy aaouee?a ie aea/aee iaaeeei–
nioe?aeuei? , a?ieia?/i?, ee?i?/i? /eiieee, ye? iiaee ni?eyoe
?icaeoeo aoii?/iiai aea?iaoeoo.

A naia: iniaeeaino?, ye? iiacycai? c i?ioan?eiith ae?yeuei?noth
aaouee?a, ?o oe?aeeea? cae/ee, noai caei?iacy aaouee?a oa ?iaee/?a
?? e?i?? ?iaeiaiaeo (caoai?thaaiiy aa?oi?o aeeoaeueieo oey-o?a,
oeoieiai – eeoeiaiai o?aeoo , iai?io ?a/iaei , aiaeie?eiii?
nenoaie) ; o iaoa?? a?aoiaoaaee ia?aa?a aaa?oiino?, iayai?noue
aanoico, iniaeeaino? iieia?a. O oai?eo ae?oae aea/aee
iniaeeaino? ia?aa?ao ia??iaeo iiaiia?iaeaeaiino?, aeaiaeiaoaaiiy,
?ioaeoe?eiee ?iaeaen, noiooith iaoieia?th. Aiae?coaaee iniaeeaino?
uaiethaaeueieo ?aaeoe?e , yeui aiie iaee i?noea. Iniaeeai
noa?aiii aea/aany aea?aieia?/iee aiaiiac, iayai?noue aea?a?/ieo
caoai?thaaiue o ?iaee/?a ? , ?? e?i?e ?iaeiaiaeo, cac ycie
aeneio c i?eeiaiiyi ?ae? , iaaee/ieo i?aia?ao?a, eieeaaiiyi
oaiia?aoo?e iia?o?y , aino?ith ?ani??aoi?iith ?ioaeoe??th,
no?anii ; a?aoiaoaaee ia??iaee/i?noue aenei?a , a oaeiae ?o
naciii?noue.

Ianoaaeaiiy ae?oae i?iaiaeeeinue a oiiaao noaoe?iia?o ?
iie?ee?i?ee a ia??iae caaino?aiiy ( aei ? i?ney e?eoaaiiy )
oa a ia??iae ee?i?/ii? ?ai?n??. ?ooeii? aeine?aeaeaiiy aeeth/aee
ee?i?/i? aiae?ce e?ia?, na/?, aaeoa??ieia?/iee aiae?c neeco
ai?ea, iina, aeine?aeaeaiiy oaeae?e ia yeoey aeeno?a, ne?ei?ia
oanoe na/? ia iayai?noue niaaeeiaeo oai?ia iai?io ?a/iaei.

Aea/aiiy ?ioiieia?/ieo iieaciee?a i?iaiaeeeinue ca
oaeeie iaoiaeeeaie:

O- nenoaia aeine?aeaeoaaeanue ca oanoii niiioaiiiai
?icaoeiooai?aiiy (M.Jondal, 1972 ) , aecia/aiiy noaiiioeyoe?? O —
e?ioioeeo?a i?iaiaeeee iaoiaeii iai?yii? ?ioiioethi?anoeaioe??
ca aeiiiiiaith iiiieeiiaeueieo aioeo?e ( ?.A.?aciee ?c
ni?aaao.,1988 ); aeey aecia/aiiy ooieoe?iiaeueii? aeoeaiino? O
– e?ioioeeo?a ( c OAA ) aeei?enoiaoaaee oano aeanoii? o?ainoi?iaoe??
(I.?.A?aoaea ?c ni?aaao.,1968) ; e?euee?noue A – e?ioioeeo?a
aecia/aee ca iaoiaeii eiiieaiaioa?iiai ?icaoeiooai?aiiy ( Mendes
et al., 1973 ) ; ai?no ?ioiiaeiaoe?i?a A,I,G o ne?iaaooe? e?ia?
ca iaoiaeii i?inoi? ?aae?aeueii? ?ioiiaeeooc?? ca Mancini ( 1965)
; ai?no ?ioiiaeiaoe?io A — ?ioiioa?iaioiei iaoiaeii (
Ae.I.?aieoeueeee ?c ni?aaao., 1988); ??aaiue ne?iaaoeiaiai
eiiieaiaioo — ii 50 % aaiie?co ( E.N.?aci?eiaa, 1967); ??aaiue
oee?eoethth/eo ?ioiieo eiiieaen?a o ne?iaaooe? e?ia? ( Oe?E )
ne?iaaoeiaee e?cioeei aecia/aee ca iaoiaeeeith C.A. ??iieue?ai?
/1968/ ; iieacieea caaa?oaiiai oa ia caaa?oaiiai oaaioeeoico
aeine?aeaeoaaee ca iaoiaeii A.A.*a?iooaiei ?c ni?aao., 1978 .

?acoeueoaoe aeine?aeaeaiue ia?iaeaii ca iaoiaeaie
aa??aoe?eii? noaoenoeee c aeei?enoaiiyi ia?aiao?e/ieo iaoiae?a (
aeyaeaiiy e?eoa??th aeinoia??iino? Nouethaeaioa).

Ee?i?/ia ianoaaeaiiy ae?oae c AAe a aino?ee ia??iae
iieyaaei o aecia/aii? aa??aioa ia?aa?ao AAe , aeyaeaii?
noiooiuei? iaoieia?? ( aeiaeaoeiaa ianoaaeaiiy EI? –e?ea?ai ,
aiaeie?eiieiaii , noiiaoieiaii , aano?iaioa?ieiaii ). C o?aooaaiiyi
a?eiai? noaae?eiino? aea?a?/iiai i?ioeano ia oe??? a aino?ee
ia??iae caoai?thaaiiy oai?? aoee iiae?eai? ia /ioe?e ee?i?/i?
a?oie : aenoaeaoeaia oi?ia — 28 ae?oae ( 24.5% ) o a?oe? 2 –
4 ?iee, i?o-?ea?iicia oi?ia — 28 ae?oae ( 24.5% ) o a?oe? 5 —
8 ?ie?a , a?eoaiaoicii — neaaiicii – e?oaii?aeia — 27 ae?oae (
23.6% ) o a?oe? 7 – 14 ?ie?a, aea?ii – ?ani??aoi?iee neiae?ii
(Ae?N) — 31 aeeoeia ( 27, 4% ) o a?oe? 3 – 14 ?ie?a. A?oio
eiio?ieth neeaee 50 caei?iaeo ae?oae ( 30 o a?oe? 3 – 7 ?ie?a ;
20 o a?oe? 8 – 14 ?ie?a) .

?acoeueoaoe aeanieo aeine?aeaeaiue oa ?o iaaiai?aiiy.
I?iaaaeaiee aiae?c nioe?aeueii – a?a??i?/ieo oa ee?i?/ieo
iniaeeainoae ia?aa?ao ??cieo oi?i AAe (aenoaeaoeaii? ,
i?o?e-a?iicii? , a?eoaiaoicii – neaaiicii – e?oaii?aeii? oa Ae?N )
aeicaieea aeyaeoe caaaeuei? oaeoi?e, ye? iaaaoeaii aieeaathoue ia
aeieeiaiiy ? ?icaeoie ??cieo aa??aio?a AAe (oaae. 1):

-aaiaoe/iee oaeoi? – ?iaeeiia noeeuei?noue aei aea?a?/ieo
caoai?thaaiue;

-iaaeeei–a?ieia?/i? oaeoi?e: a?e aaouee?a noa?oa 26 ?ie?a ,
o?ii?/i? caoai?thaaiiy aa?oi?o aeeoaeueieo oeyo?a oa oeoieiai –
eeoeiaiai o?aeoo o aaouee?a ae?oae

c AAe , iaoieia??th oe??? aaa?oiino? o iaoa??a (aanoic ?
, ?? iieiaeie, caa?ica ia?a?eaaiiy aaa?oiino?); iaaeoi ?aii? ooo/ia
aeaiaeiaoaaiiy, o?ii?/i? aiaieua ?ioae oe?? EI? — i?aai?a ,
ea???n coa?a, iaoieia?y oeoieiai — eeoeiaiai o?aeoo o ae?oae c
AAe ;

OAAEEOess ?1

*anoioa aeyaeaiiy iani?eyoeeaeo nioe?aeueii – a?a??i?/ieo , iaaeeei
– a?ieia?/ieo

oa niaaeeiaeo oaeoi??a o ae?oae c ??cieie oi?iaie aoii?/iiai
aea?iaoeoo (?±?%).

Nioe?aeueii –a?a??i?/i? , iaaee-ei- a?ieia?/i? , niaaeeia? oae-oi?e
?eceeo *anoioa aeyaeaiiy iani?eyoeeaeo oaeoi??a (%).

Aenoaeaoeaia I?o?ea?iicia A?eoaiaoicii- Aea?ii?an —

oi?ia oi?ia neaaiicii- i??aoi?iee

% % e?oaii?aeia % neiae?ii
%

n = 28 n = 28 n = 27 n
= 31 1.Aeieia?/ii iani?eyoeea?

oiiae i?iaeeaaiiy. 92,8±4,9 100
100 100 2.Iani?eyoeea? aeeoeiai-

iiaooia? oiiae 92,8±4,9 85,8±6,7 74,0±8,5
83,9±6,7 3.”E?oi?e “ a?e aaouee?a. 60,7±9,3
46,5±9,5 55,5±9,7 54,8±9,0 4.Oe?aeeea? oaeoi?e
iaoe-

ae?iaieoeoaa: aaoueei- 42,8±9,5 42,8±9,5
33,3±9,2 9,6±5,3

42,8±9,5 28,5±8,6 25,9±8,5 16,1±6,7
5.Oe?aeeea? cae/ee iaoe-

(eo??iiy) aaoueei- 42,8±9,5 25,0±8,3
44,4±9,7 25,8±7,9

78,5±7,9 75,0±8,6 77,7±8,2 54,8±9,0
6.Iayai?noue aeiiaoi?o oaa?ei. 35,7±9,2 14,2±6,7
48,1±9,8 23,3±7,7 7.O?ii?/i? caoai?th- iaoe-

aaiiy aaouee?a aaoueei- 50,0±9,6 53,5±9,5
59,2±9,6 54,8±9,0

25,0±8,3 28,5±8,6 22,2±8,1 29,0±8,2
8.Niaaeeiaa iaoyaeaii?noue ii

aea?a?/ieo caoai?thaaiiyo. 64,2±9,2 60,7±9,3
59,2±9,6 48,3±9,1 9.Iaoieia?y oe??? aaa?oiino? .
71,4±8,6 75,0±8,3 66,6±9,2 74,1±7,9
10.I?eioe a oa?/oaaii? iaoa??. 39,2±9,3 50,0±9,6
44,4±9,7 32,2±8,511.Iaoieia?y iieia?a. 32,1±8,9
46,4±9,5 14,8±6,9 45,1±9,012.Ia?eiaoaeueia
iaoieia?y. 25,0±8,3 25,0±8,3 22,2±8,1
29,0±8,213.?aii? ooo/ia aeaiaeiaoaaiiy. 75,0±8,3 64,2±9,2
55,5±9,7 45,1±9,9 14.Iiyaa aea?a?/iiai aeneio

aei 1 ?ieo 89,2±5,9 67,8±8,9 77,7±8,2
48,3±9,115.EI? – iaoieia?y ( noiooiy). 35,7±9,2 50,0±9,4
40,7±9,6 58,0±9,0 16.Iaoieia?y oeoieiai –eeo-
eiaiai o?aeoo. 21,4±7,8 39,2±9,3 44,4±9,7
23,3±7,7

-nioe?aeueii– a?a??i?/i? oaeoi?e: iani?eyoeea? oiiae i?iaeeaaiiy
ae?oae , aeeoeiai –iiaooia? ( 3 – 7 i 2 aeeoeiai? ieiu? ia iaeio
ethaeeio o n?ic?, ui i?eionea? aenieo eiioeaio?aoe?th
aioeaai?a o oeeo oiiaao ) ; cacycie c oe?aeeeaeie aeeeaeaie
ae?iaieoeoa o iaaeieeoi? na?aaeiaeua.

I?e ii??aiyii? ae?? iani?eyoeeaeo oaeoi??a aoei aeyaeaii ?o
a?eueoo cia/ei?noue aeey ae?oae c e?oaii?aeieie i?iyaaie AAe ,
i?ae c aenoaeaoeaieie.

Aeiaeaoeiaeie iaoiaeaie anoaiiaeaii : a ee?i?/iiio
aiae?c? e?ia? o ae?oae c ??cieie oi?iaie AAe — aiceiio?e?y,
iiiioeeoiiai?y , o ae?oae c aenoaeaoeaieie i?iyaaie — iii??ii
ae?aaeaiee iaeo?io?eueiee eaeeioeeoic ; a aiae?cao na/? i?e ?aii?o
oi?iao AAe ( aenoaeaoeaieo) a?aecia/aeanue iii??ia ienaeaoo??y , o
ae?oae c ae?aaeaiith o?ii?caoe??th oe??iiai i?ioeano (a?eoaiaoicii
– neaaiicii – e?oaii?aeiith oi?iith AAe) ? Ae?N o na/iaiio inaaeeo
aeiaaeaee ienaeaoe , oinoaoe , o?aoe ; i?e OCAe ie?ie o oeeo
ae?oae niinoa??aaeanue nieueiaa ?ie?onoaoe?y ienie iaei??? aai
iaio ie?ie. A??ia?aeii, c a?eii oa iia??oaiiyi ia?aa?ao AAe
a?aeaoaathoueny ii?ooaiiy a i?ia?aeueiiio iai?i?.

Iayai?noue i?e?ioei?e ( iaoieia?/iee noao?eieie oa no?aioieie) aoei
cao?eniaaii o o?aoeie ae?oae c aenoaeaoeaieie oa i?o?ea?iicieie
i?iyaaie AAe (39.2% ? 35.7% a?aeiia?aeii ) , o 48,1% ae?oae c
Ae?N ? 62,9% c a?eoaiaoicii — neaaiicii — e?oaii?aeieie i?iyaaie.
Aeyaeaiiy o aenieeo oeo?ao aioeo?e aei no?aioieiea o oai?eo c
??cieie AAe aeaco? ia iiaeeeao o/anoue eieiai? ?ioaeoe?? a
i?e?iai?e nainea?e?caoe?? i?aai?cio i?e AAe

Iaie aeyaeaii o ae?oae c AAe i?eai?/aiiy ianiaoeeo?/ieo
oaeoi??a caoenoo ( caaa?-oaiiai oa iacaaa?oaiiai oaaioeeoico ,
??aiy eiiie?iaioo , ne?iaaoeiaiai e?cioeeio). Na-?aaei? cia/aiiy
iieaciee?a oaaioeeoico aoee ieae/a eiio?ieueieo oeeo?, iniaeeai
iieacieee oaaioeeoa?iiai ?iaeaeno oa ?iaeaeno ia?aaa?thaaiiy o
ae?oae c ??cieie i?iyaaie AAe ( 2.4 % — 3.2 % o ii??aiyii?
c 5.1 % eiio?ieueii? a?oie ; ?iaeaen ia?aaa?thaaiiy 6.0 % — 7.1 %
o ii??aiyii? c 8.6 % o eiio?ie? ).O a?eueoino? ae?oae ( 72 % )
ne?iaaoeiaee e?cioeei aoa cieaeaiee. Aeyaeaii cieaeaiiy
eiiieaiaioa?ii? aeoeaiino? ne?iaaoee e?ia? o 67.8% ae?oae c
aenoaeaoeaieie i?iyaaie AAe , o 69.3 % — c i?o?ea?iicieie, o
81.0% — c a?eoaiaoicii — neaaiicii — e?oaii?aeieie ? o 93% —
c Ae?N.

Ie niinoa??aaee ci?ie ? a aoii?aeuei?e eaioe? eioi?oaoo (
oaae. ? 2 ) o ae?oae c ??cieie ee?i?/ieie oi?iaie AAe :
cieaeaiiy ai?noo ?ioiiaeiaoe?i?a A, I, G o 25% ae?oae c
aenoaeaoeaiith oi?iith, o 15.3 % — c i?o?ea?iiciith, o 33.3%
ae?oae c a?eoaiaoicii- neaa-iicii – e?oaii?aeiith ? o 23.3% — c
Ae?N . A?eueoa i?ae 70.0 % ae?oae eiaeii? aeine?aeaeoaaii?
a?oie iaee cieaeaiee ??aaiue Ig M o ne?iaaooe? e?ia? o
ii??aiyii? c eiio?ieueiith a?oiith.

?iaeea?aeoaeueiee aiae?c ?ioiia?ai ae?oae c AAe iieacaa,
ui aeen?ioiiaeiaoe?iai?? (ii E.?.Oeiiia? oa O. Iieoaon, 1979 )
aoee anoaiiaeai? a on?o a?oiao ae?oae , ui ianoaaeo-aaeenue.
Caaaeueieie aeey an?o ee?i?/ieo aa??aio?a AAe aoee /ioe?e
oeie aeen?ioiiaeiao-e?iai?e ( ?, ???, V ,VII ) .
Aeen?ioiiaeiaoe?iai?? ? , ??? , VII oei?a niinoa??aaeenue o
ae?oae c o?ii?/ieie aiaieuaie ?ioaeoe?? EI?- i?aai?a, iin??a
iaoiaaiii? i?e?ioei?e iiniaeioee, iaoyaeaiith niaaeeia?noth ii
aea?a?/ieo caoai?thaaiiyo ( ?ani??aoi?iei aea?aicii ) ?
caoai?thaaiiyo i?aai?a aeeoaiiy ; V oei aeen?ioiiaeiaoe?iai??
niinoa??aaany ia?aaaaeii o ae?oae c iaoieia??th oeoieiai –
eeoeiaiai o?aeoo oa iaoyaeaiith niaaeeia?noth ii caoai?thaaiiyo
nenoaie o?aaeaiiy. I/aaeaeii, o?ii?/ia iaoieia?y i?aai?a aeeoaiiy
oa nenoaie o?aaeaiiy noai?th? oiiae aeey a?eueo eaaeiai
i?iieeiaiiy a i?aai?ci aea?aai?a , nainea?e?caoe?? oa ii?ooaiiy
ae?i?iaoe?? ?ioiieo eiiieaen?a.

Eiioeaio?aoe?y IgE o ianoaaeaieo ae?oae c aoii?/iei aea?iaoeoii
aoea i?aeaeuaia: o ae?oae c aenoaeaoeaieie i?iyaaie — (312.6 ±
38.4) II/ie, i?o?ea?iicieie — (378.9±32.3) II/ie ? o ae?oae
iieiaeoi? a?eiai? a?oie c Ae?N — ( 484.2 ± 32.6) II/ie /o
eiio?ie? —

( 83.5±17.2 ) II/ie/ .O ae?oae c a?eoaiaoicii —
neaaiicii–e?oaii?aeieie i?iyaaie AAe –

( 393.0± 27.1) II/ie ? noa?oi? a?oie ae?oae c Ae?N — (418.1±48.7
) II/ ie / o eiio?ie? –

( 98.5± 15.3) II/ie/.

I?aeaeuaiiy oee?eoethth/eo ?ioiieo eiiieaen?a ie niinoa??aaee
o 71.9% ae?oae c i?i-yaaie AAe.

Aeine?aeaeaiiy iieaciee?a ee?oeiiiai ?ioi?oaoo ( oaae. 2)
aeicaieeei aeyaeoe

o 74.2% ae?oae c AAe cieaeaiiy e?eueeino? O-e?ioioeeo?a, ?o
ooieoe?iiaeueii? aeoeaiino? , o 84.2% i?aeaeuaiiy e?eueeino? A –
e?ioioeeo?a o ia?eoa?e/i?e e?ia? . I?e aeine?aeaeaii?
noa-iiioeyoe?? O — e?ioioeeo?a ( CD4+ – O–oaeia??a , ND8+ – O–
noi?ani??a) aoee iaea?aeai? oae? ?acoeueoaoe: e?euee?noue O –
oaeia??a aoea ii?iaeueiith o ae?oae c “ /enoeie “ oi?iaie AAe , o
ae?oae Ae?N ??aaiue O – oaeia??a o a?aeiinieo /eneao aoa
cieaeaiee aei 33.0 % / iieiaeoa a?eiaa a?oia/ oa aei 30.2% a
noa?o?e a?eia?e a?oi? (eiio?ieue — 41.5% oa 41.9% a?aeiia?aeii).
Oeeoioiene/ia aeoeai?noue O — e?ioioeeo?a ( CD 8+ ) , ca iaoeie
aeaieie , aoea aeinoia??ii cieaeaiith a on?o ae?oae c ??cieie
ee?i?/ieie oi?iaie AAe : i?e aenoaeaoeai?e oi?i? a?aeiinia
e?euee?noue O- noi?ani??a neeaaeaea ( 15.5±0.2) % , i?e i?o?ea?iici?e
— (16.4±0.5) %, niieo/ai?e c ?ani??aoi?iei aea?aicii (iieiaeoi?
a?oie) — ( 13.0±1.1) %, o eiio?ie? — (23.3±2.6)%, o ae?oae c
a?eoaiaoicii–neaaiicii–e?oaii?aeieie i?iyaaie AAe — ( 15.6±0.9) % ?
o ae?oae c Ae?N (noa?oeo ca a?eii — ( 13.5±0.8) % , o eiio?ie?
— ( 23.2±1.2) %.

Oaaeeoey 2

Iieacieee ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo o ae?oae c

??cieie ee?i?/ieie oi?iaie aoii?/iiai aea?iaoeoo ( I±m).

A?oie

ianoa-aeoaa-ieoEaeei

oeeoe

aan.

/enei

* 106 /e E?ioi

oeeoe

% O-

e?ioi-

oeeoe

% Ooieoe?iiaeueia

aeoeai?noue

O–e?ioioeeo?a %

Niiio. n OAA A e?ioi- oeeoe

% ?ioiiaeiaoe?ie a / e

A I G1.Aenoae.

oi?ia

(n=28)

7916

± 63

45.5

± 2.4

53.5

± 0.8

12.0±0.4 5.8±0,4.9

12,5

±0,1

0,91±0,01 0,78 ±0,01 8,5±0,3

2.I?o?.

oi?ia

( n=28)

6673

± 62

47.0

± 1.8

47.1

± 0.8

15.0±0.356,3±0,9

14,1

±0,9

1,08±0,02 0,81±0,01 8,67±0,083.Ae?N

(3-7 ?ie)

(n=16)

6443

±154

41.1

± 1.6

40.8

± 1.6

*

15.7±0.5 45,1±1,8

12,6

±0,4

0,91±0,02 0,82±0,01 8,51±0,15Eiio?.

A?oia

(3-7?ie)

(n = 30)

7474

±177

32.9

± 0.8

47.3

± 1.2

16.1±0.659,1±1,0

12,5

± 0,5

1,01±0,04 0,90±0,05 9,3±0,24.A?eo-nea.-e?o.

(n=27)

7144

±113

46.8 ± 0.7

53.1

± 1.4

7.2±0.3 50,2±1,8

12,4

±0,9

1,21±0,02 0,86±0,01 8,08±0,135.Ae?N

(8-14 ?ie?a)

(n=15)

6900

±132

38.9

± 1.9

31.3

±2.2

**

8.9±0,9 51,1±1,3

13,5

±0,8

1,19±0,02 0,71±0,01 8,8±0,2Eiio?.a?

(8-14 ?ie?a)

(n=20)

7000

± 80

37.7

± 1.5

55.8

± 4.3

8,0±0,5 56,1±1,6

14,6

±1,2

1,32±0,04 1,01±0,05 9,1±0,2 * ? < 0.01, ** p< 0.001 sse cacia/aeinue iiia?aaeiuei , e?euee?noue O– oaeia??a aoea ii?iaeueiith , e??i ae?oae c Ae?N, a O- noi?ani??a cieaeaiith. Ioaea, ie iaea?aeaee aenie? iieacieee ioii?aaoeyoi?iiai ?iaeaeno ( ??? ) aeey a?eueoino? ae?oae c AAe ( 2.23 – 2.73; o eiio?ie? – 1.8±0.2 ), ui na?ae/eei i?i iai?oaeai?noue ?ioiieo i?ioean?a o oai?eo ia AAe. ?iaeea?aeoaeueiee aiae?c ?ioiia?ai iieacaa , ui o 76 ae?oae ( 66.6 % ) oeeoioiene/ia aeoeai?noue e?ioioeeo?a (CD8+ ) aoea ??cei i?eai?/aiith. E?eoaaiiy ae?oae ie i?iaiaeeee ca ?iaeea?aeoaeueiith noaiith. O eiaeiiio aeiaaeeo i?e oeueiio a?aoiaoaaee ee?i?/io oi?io AAe , iayai?noue caaino?aiiy, noiooith iaoieia?th, a oaeiae ?acoeueoaoe aeiaeaoeiaeo ianoaaeaiue. Aeai?eoi e?eoaaiiy a aino?ee ia??iae aeeth/aa: a?iiaea?aaiio ae??oo, aioea?noai?ii? i?aia?aoe ei?ioei? oa niia?eueiaii? ae?? , naaeaoeai? caniae , o?c?ioa?aiaaoe/i? i?ioeaaeo?e, eieaeueia oa?ai?y i?iaiaeeeanue c o?aooaaiiyi oa?aeoa?o iaoieia?/iiai i?ioeano ia oe??? (iieioooy, aoi?eiia ?ioaeoaaiiy, e?oai?o?eaoe?y). Iaoith niaoe?aeueiiai aea/aiiy aoea ioe?iea oa?aiaaoe/ii? aoaeoeaiino? aioa?ini?aaio?a (EAA –1,ni?aiaaeue) oa ?ioiiiiaeoeyoi?a oeiiaaia ( a ia??iae ee?i?/ii? ?ai?n?? ) a eiiieaeniiio e?eoaaii? ae?oae , oai?eo ia AAe . Aea/aiiy ee?i?ei–?ioiieia?/ii? aoaeoeaiino? aioa?ini?aaio?a oa oeiiaaio aoei cae?eniaii iaoiaeii ii??aiyiiy ?acoeueoao?a e?eoaaiiy oai?eo, ye? io?eioaaee ia oii? eiiieaenii? oa?ai?? aeuaiacaai? i?aia?aoe (69 ae?oae) c oeie , ye? io?eioaaee eeoa ia-oiaaiaoe/io oa?ai?th (45 ae?oae) aac aioa?ini?aaio?a oa ?ioiiiiaeoeth/eo cania?a. Aioa?ini?aaioe i?ecia/aee ca oaeith noaiith : EAA - 1 o aeic? 50 ia / ea iane o?ea , c?aieo, iaouana?oea ca 2 aiaeeie aei ?ae? ( ?ic/eiai? a 50 – 100 ie aiaee), i?ioyaii 1 oeaeiy; ni?aiaaeue i?ecia/aee ae?oyi aei 3 ?ie?a 5 ie ia aeiao, 4 – 9 ?ie?a - 10 ie ia aeiao, 10 – 14 ?ie?a - 20 ie ia aeiao aea?/? ia aeaiue ca aea? aiaeeie aei ?ae? i?ioyaii oeaeiy. Aiae?c ?acoeueoao?a i?iaaaeaii? oa?ai?? c aioa?ini?aaioaie iieacaa oaea : aei e?ioey ia?oiai oeaeiy e?eoaaiiy o ae?oae iaei i?noea iie?ioaiiy ( ciaioeeinue caiaeaiiy oe??e, naa?a?iiy ) , aei e?ioey 3 – 4 oeaeiy niinoa??aaeinue i/euaiiy oe??e , ai?oae?caoe?y o?aaeaieo i?noeue. O aaiia?ai?: e?euee?noue aiceiio?e?a ciaiooaaeanue o 1.5 – 2 ?ace , iiiioeeo?a ca?eueooaaeanue o 1.5 ?ace, cia/ii aeoea?coaaeanue oaaioeeoa?ia nenoaia , iniaeeai o ae?oae c aenoaeaoeaieie oa i?o?ea?iicieie i?iyaaie AAe (na?aaei? iieacieee caeaoiino? oaaioeeo?a iiaeeiaoe oa ia?ao?aaethaaoe noao?eieie ooaio ? 209 iaaeeaeaeenue aei eiio?ieueieo oeeo?),iaaeeceany aei ii?ie ??aaiue ne?iaaoeiaeo ?ioiiaeiaoe?i?a A, I, G. Aaaiieo iiceoeaieo ci?i o iieacieeao ee?oeiiiai ?ioi?oaoo, ??ai? IgE, eiioeaio?aoe?? Oe?E i?ney eiiieaeniiai e?eoaaiiy ae?oae c AAe c aeei?enoaiiyi aioa?ini?aaio?a ie ia niinoa??aaee. A a?oi? ae?oae, ye? ia io?eioaaee aioa?ini?aaioe, ia oii? o?aaeeoe?eiiai e? eoaaiiy ee?i?/ia iie?ioaiiy ie niinoa??aaee a e?ioe? icyoiai oeaeiy, a aaiia?ai? oa ?ioiieia?/ieo iieacieeao nooo?aeo ci?i ia aoei . A ia??iae ee?i?/ii? ?ai?n?? oai?ei c ii?ooaiiyie O- ee?oeiii? eaiee ?ioi?oaoo ( 69 ae?oae ) aoei i?iaaaeaii ?ioiiei?aeoe?th oeiiaaiii. I?aia?ao oeiiaai i?ecia/aee uiaeaiii iaeei ?ac ia aeiao a/i i?ioyaii 7 - 10 aei?a ae?oyi o a?oe? 2- 4 ?iee ii 20 iea, 5 – 6 ?ie?a - 30 iea, 7– 14 ?ie?a ii 50 iea. Aeine?aeaeaiiy ?ioiiiai noaoono ae?oae i?iaiaeeeinue /a?ac o?e i?nyoe? i?ney e?eoaaiiy ca?aeii c ?aeiiaiaeaoe?yie I.?.Eaneoe? oa .I.Neaeaeuei?eiaa(1991). ?ioiieia?/i? iieacieee ae?oae i?ney aeei?enoaiiy oeiiaaio cia/ii iie?ioeeenue: ca?eueoeeanue e?euee?noue O - e?ioioeeo?a o a?eueoino? ae?oae c AAe ( i?e aenoaeaoeai?e oi?i? c 53.5% aei 60.2% , i?o?ea?iici?e - c 47.1 % aei 58.3 % , a?eoaiaoicii–neaaiicii- e?oaii?aei?e c 53.1% aei 57.4% ? iniaeeai o ae?oae c Ae?N - c 31.3% aei 51.8% ). Aeaui ca?eueoeeanue ? e?euee?noue A–e?ioioeeo?a, iniaeeai o ae?oae c aenoaeaoeaiith oi?iith AAe c 12,5% aei 14.7 % . Ooieoe?iiaeueia aeoeai?noue O- e?ioioeeo?a c a?eoaiaoicii – neaaiicii – e?oaii?aeieie i?iyaaie oa aea?ii?ani??aoi?iiai neiae?iio iaea oaiaeaioe?th aei i?aeaeuaiiy i?ney ?ioii-ei?aeoe?? c oeiiaaiii. Iieacieee ne?iaaoeiaeo ?ioiiaeiaoe?i?a A, I, G i?ney e?eoaaiiy oeiiaaiii aeinya-ee eiio?ieueiiai ??aiy. Ie niinoa??aaee nooo?a? ci?ie a ?ioii?aaoeyoi?i?e eaioe? i?ney i?iaaaeaiiy ?ioii-ei?aeoe?? oeiiaaiii ( ?en. 1 ): ai?no CD8+ (O - noi?ani??a ) a ia?eoa?e/i?e e?ia? o a?eue-oino? oai?eo iaa oaiaeaioe?th aei a?aeiiaethaaiiy ( i?e aenoaeaoeai?e oi?i? c 15.5 % aei 20.2% , i?o?ea?iici?e - c 16.4 % aei 19.3 % , a?eoaiaoicii - neaaiicii – e?oaii?aei?e - c 15.5% aei 20.5 % , Ae?N - c 13.0 % aei 18.8 % ) . Nooo?ai cieceany ?ioii?aaoeyoi?iee ?iaeaen. ?iaeea?aeoaeueiee aiae?c ?ioiia?ai iiea-caa , ui o 25 ae?oae c AAe ??aaiue O- noi?ani??a ia aeinya ii?ie. Oeei ae?oyi aoea i?iaa-aeaia iiaoi?ii ?ioiiei?aeoe?y oeiiaaiii . Eaoaiianoe/i? aeine?aeaeaiiy iieacaee, ui o 22 ae?oae i?aeoe/ii an? iieacieee ?ioi?oaoo aeinyaee ii?iaeueiiai ??aiy. Niinoa?aaeaiiy i?ioyaii aeaio ?ie?a ca oeeie ae?oueie na?ae/eei , ui o ieo ciaioeeanue e?euee?noue caaino?aiue AAe , yeui ae ? iaee i?noea ?aoeeaeeae, ?o ia?aa?a oa?aeoa?ecoaaany i’ye?noth. O ae?oae c Ae?N ia a?aecia/aeinue caaino?aiue ?ani??aoi?iiai aea?aico. % % 60 Aenoaeaoeaia oi?ia 60 I?o?ea?iicia oi?ia 50 50 40 40 30 30 20 20 10 10 0 ND 3+ CD 4+ CD 8+ CD3+ CD4+ CD 8+ % % 60 A?eoaiaoicii-neaaiicii- 60 Aea?ii?ani??aoi?iee neiae?ii e?oaii?aeia oi?ia. 50 50 40 40 30 30 20 20 10 10 0 0 CD3+ CD 4+ CD 8+ CD 3+ CD4+ CD 8+ ?en. 1 Aeeiai?ea iieaciee?a noaiiioeyoe?e O – e?ioioeeo?a o ae?oae c ??cieie oi?iaie AAe - ii?ia, - aei e?eoaaiiy, - i?ney e?eoaaiiy oeiiaaiii, - i?ney e?eoaaiiy o?aaeeoe?eieie iaoiaeaie ,CD3+ - caaaeuei? e?ioioeeoe, CD 4+- O- oaeia?e , CD 8+ - O-noi?ani?e . Oaeei /eiii, ae?oyi c ??cieie ee?i?/ieie oi?iaie AAe iaiao?aeii i?iaiaeeoe eiiieaenio oa?ai?th c o?aooaaiiyi oi?ie oa noaae?? caoai?thaaiiy. A aino?ee ia??iae ii?yae c iaoiaaiaoe/iei e?eoaaiiyi ( a?aoiaoth/e noiooith iaoi-eia?th o aeeoeie) iaiao?aeii aeiaeaaaoe aioa?ini?aaioe, ye? ni?eythoue aeoeaaoe?? ianiaoeeo?/ieo oaeoi??a caoenoo. A ia??iae ee?i?/ii? ?ai?n?? i?e aeenooieoe?? ee?oeiiiai ?ioi?oaoo ( iniaeeai i?e i?eai?/aii? noi?ani?ii? aeoeaiino? O–e?ioioeeo?a ) ?aeiiaiaeo?oueny i?iaiaeeoe ?ioiiei?aaoth/o oa?ai?th oeiiaaiii . AENIIAEE 1.Aoii?/iee aea?iaoeo ? oyaeeei caoai?thaaiiyi ae?oae, yea i?iyaey?oueny ??cieie ee?i?/ieie oi?iaie - a?ae ?aii?o aenoaeaoeaieo ( 24.5%) , i?o?ea?iicieo ( 24.5%) aei i?ci?oeo e?oaii?aeieo (23.6% ) oa o niieo/aieo c ?ani??aoi?iei aea?aicii - aea?ii – ?ani??aoi?iei neiae?iiii ( 27.4%) . 2.Na?aae oaeoi??a ?eceeo iaea?eueoa cia/aiiy iathoue niaaeeiaa iaoyaeai?noue ii aea?a?/ieo caoai?thaaiiyo , ?aii? ooo/ia aeaiaeiaoaaiiy , ia?eiaoaeueia iaoieia?y, a oaeiae iani?eyoeea? aeieia?/i? oiiae. 3.O a?eueoino? oai?eo aoii?/iee aea?iaoeo ia?aa?aaa ia oii? o?ii?/ieo aiaieu ?ioae-oe?? EI? – i?aai?a (46.5%), ea???no coa?a (16.6 %) oa ooieoe?iiaeueieo caoai?thaaiue oeoi-eiai- eeoeiaiai o?aeoo (31.5%) , eio?? iiaee ni?eyoe nainea?e?caoe?? i?aai?cio aaeoa??-aeueieie aioeaaiaie. 4. A ia??iae caaino?aiiy AAe an? ee?i?/i? oi?ie oa?aeoa?ecoaaeeny ii?ooaiiyi oae-oi??a ianiaoeeo?/iiai caoenoo: cieaeaiiyi iieaciee?a oaaioeeoico( iiaeeiath/i? oa e?e?i-aiai? ooieoe?? iaeo?io?e?a ), ne?iaaoeiaiai e?cioeeio oa eiiie?iaioo, ui ni?eyei a aa-aaoueio aeiaaeeao aoi?eiiiio i?e?iaiiio ?io?eoaaiith oe??e. 5. Ci?ie a aoii?aeuei?e eaioe? ?ioi?oaoo oa?aeoa?ecoaaeenue iayai?noth o 74.0 % ae?oae aeen?ioiiaeiaoe?iai?e ?, ???, V oa VII oei?a , cieaeaiiyi ??aiy Ig M(70.0%) , a?ia?-?ioiiaeiaoe?iai??th A (86.0%) oa a?ia?eiiieaenai??th ( 71.9%). 6. Ci?ie ee?oeiiiai ?ioi?oaoo i?iyaeyeenue aieiaiei /eiii ii?ooaiiyi ooie-oe?iiaeueii? aeoeaiino? O- e?ioioeeo?a ( 74.6% ). O a?eueoino? oai?eo (66.6 %) niinoa??aaeinue i?eai?/aiiy noi?ani?ii? aeoeaiino? O– e?ioioeeo?a ( ND8+ ) oa i?aeaeuaiiy ?ioii-?aaoeyoi?iiai ?iaeaeno. 7. Oaeoeea e?eoaaiiy iiaeiia aoaeoaaoeny ia ?iaeea?aeoaeueieo iniaeeainoyo eiaeiiai oai?iai c o?aooaaiiyi oace iaoieia?/iiai i?ioeano (aino?a, o?ii?/ia), ee?i?/iiai aa??ai-oo aoii?/iiai aea?iaoeoo oa iieacieeao ?ioiieia?/ieo aeine?aeaeaiue. 8. Canoinoaaiiy a oa?aiaaoe/iiio eiiieaen? aioa?ini?aaio?a ( EAA – 1 , ni?aiaaey) a ia??iae? caaino?aiiy ni?ey? ae?i?iaoe?? ?ioiieo eiiieaen?a oa a?aeiiaeaiith iania-oeeo?/ieo oaeoi??a caoenoo (oaaioeeoico, eiiie?iaioo, e?cioeeio). 9. Iaa?oiooaaiiyi aeey i?ecia/aiiy a ia??iae ?ai?n?? ae?oyi c aoii?/iei aea?iaoeoii ?ioiiiiaeoeyoi?a oeiiaaia ? aeyaeai? ci?ie a ee?oeii?e eaioe? ?ioi?oaoo. I?ae aieeaii oeiiaaio ii?iae?coaaeanue ooieoe?iiaeueia aeoeai?noue O - e?ioioeeo?a , ca?eueoeeanue e?eue-e?noue O – noi?ani??a ( CD8+ ), iiceoeaii ci?ieany ?ioii?aaoeyoi?iee ?iaeaen ; cia/ii ciaioeeanue /anoioa caaino?aiue, ?ai?n?y iaaoea a?eueo no?eeiai oa?aeoa?o . I?AEOE*I? ?AEIIAIAeAOe?? 1.A iaae?ao?e/i?e i?aeoeoe? i?iiiio?oueny aeae?eaiiy iniiaieo ee?i?/ieo aa??aio?a aoi-i?/iiai aea?iaoeoo : aenoaeaoeaiiai, i?o?ea?iiciiai , a?eoaiaoicii – neaaiicii – e?oaii?ae-iiai oa aea?ii-?ani??aoi?iiai neiae?iio. 2. I?e aecia/aii? nooiaiy ?eceeo AAe iaiao?aeii a?aoiaoaaoe oae? /eiieee: - iayai?noue o i?iaaiaea aeecueeeo ?iaee/?a ii e?i?? aaoueea /e iaoa??, oai?eo ia aea?-a?/i? caoai?thaaiiy ; - iayai?noue ia?eiaoaeueii? iaoieia?? ; - ooo/ia aeaiaeiaoaaiiy ; - ?aii? i?iyae aea?a?/iiai aeneio ia oe??? aeeoeie i?e ooo/iiio aeaiaeiao- aaii? ; - iani?eyoeeaee noai iaaeieeoiueiai na?aaeiaeua ; - iayai?noue aiaieu o?ii?/ii? ?ioaeoe?? ( EI? – i?aai?a, coa?a) ; - caoai?thaaiiy oeoieiai – eeoeiaiai o?aeoo ; 3. Aeey aeyaeaiiy aeaoaeo?a ?ioi?oaoo o ae?oae , oai?eo ia AAe , ne?ae aeei?enoiaoaaoe aeine?aeaeaiiy ee?oeiii? oa aoii?aeueii? eaiie ?ioi?oaoo ( ? oa ?? ??aaiue) , a oaeiae ianiaoeeo?/ieo oaeoi??a caoenoo ( oaaioeeoic , eiiie?iaio, e?cioeei). 4. E?eoaaiiy oai?eo ?aeiiaiaeo?oueny i?iaiaeeoe ca ?iaeea?aeoaeueieie i?ioieieaie c o?aooaaiiyi oace iaoieia?/iiai i?ioeano ( aino?a, o?ii?/ia) oa ee?i?/ii? oi?ie AAe : a) a aino?o oaco : - aieia? eiii?ane, i?ioecaiaeuei? caoiaee ; - o aeiaaeeao ?io?eoaaiiy aeioe?eueia i?noeaaa aeei?enoaiiy ai?e?iiaeo aa?aiee?a ( 1 – 2 % ?ic/ei iaoeeaiiaiai neiueiai , ?ic/ei i?ieoai?io) , aioea?ioee?a, i?ioea?eaeiaeo i?aia?ao?a ; - i?ioecoaei? caniae ?c a?oie aioea?noai?iieo cania?a ( noi?anoei , oaaaa?e, eea?eoei) ; - ei?oeeinoa?i?aei? ianoeea i?ney cieeiaiiy iieioooy (ai?iaeiaae 5– 7 aei?a) ; - e?eoaaeuei? eoiae? (e?ioiaeuei?, c aen?aeaie ceae?a , c ia?iaiaaiaoii eae?th ?ic/ei 1 : 10000) ; a) a o?ii?/io oaco : - ia ?aeiiaiaeo?oueny i?eeiaoe eoiae? c ieeii , a oaeiae ii/eoe oe??o aiaeith (aion, noaoaa? i?aaie, aeneey?i? caiaaeeie o?aaa aeoe?aoe aieiaith oeaieiith) ; -i?noeaai ?aeiiaiaeo?oueny e?i?iaio iaooaeainueei? iaooe 10% ( iaiacoaaoe oe??o aea?/? ia aeaiue oiieei oa?ii) ; -i?noey, ye? naa?aeyoue, ciacaoe ei?oeeinoa?i?aeieie ianoeeaie ( oeaeanoiaea?i V, aaoaiaoacii). Ia iaee//? ia aeei?enoiaoaaoe ei?oeeinoa?i?aee , ui ai?uothoue ooi?. a)oiiiaa e?eoaaiiy o a?eiaeo aeicao: - ae?i?iaoe?eia ae??oa i?e iayaiino? oa?/iai? aea?a?? ; - oa?iaioioa?ai?y ( iaineae?e , iaiceii?i , iacei - oi?oa ? ?i.) ; - naaeaoeai? caoiaee ( aaea??aia) ; - a?oai?iioa?ai?y ( ?ao?iie , a?oai?ie A , A , A 6 ,N) ; - aioa?ini?aaioe ( EAA – 1 , ni?aiaaeue). 6. I?e aeenooieoe?? ee?oeiiiai ?ioi?oaoo ?aeiiaiaeo?oueny a ia??iae ?ai?n?? aeei?enoi- aoaaoe ?ioiiiiaeoeyoi? oeiiaai . 7.Naiaoe?y aiaieu o?ii?/ii? ?ioaeoe?? ( EI? – i?aai?a , coa?a) , e?eoaaiiy noiooiuei? ia- oieia?? oeoieiai – eeoeiaiai o?aeoo , a oaeiae ?ioeo i?aai?a. IA?AE?E I?AOeUe , IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1.Naieiaa E.A. Oaeoi?u ?enea ?acaeoey aoiie/aneiai aea?iaoeoa o aeaoae //A?niee i?iaeai a?ieia?? ? iaaeeoeeie.-1998.-?23.-N.93-96. 2.Naieiaa E.A., Eaiei A.I. I?eiaiaiea oeiiaaia a oa?aiee aeaoae n aea?ii-?anie?aoi?-iei neiae?iiii ( aoiie/aneee aea?iaoeo a ni/aoaiee n ?anie?aoi?iui aeea?aicii)// A?n-iee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.-?24.-N.85-88. 3.Naieiaa E.A. Eeeieei – eiioiieiae/aneea iniaaiiinoe aeaoae n ?acee/iuie eeeie/an-eeie aa?eaioaie aoiie/aneiai aea?iaoeoa //A?niee i?iaeai a?ieia?? ? iaaeeoeeie.-1999.-?1.-N.63-66. 4.Aaeici?iaa I.E., E?euaiei I.I., Naieiaa E.A. A?uioeiaa N.N. ?iaeiia A.A. Eeeieei-ei-ioiieiae/aneay oa?aeoa?enoeea aeaoae n aeea?ae/aneeie i?iyaeaieyie ia oiia /anoie ?anie?aoi?iie caaieaaaaiinoe//Io?aia caei?iauey aeaoae e iiae?inoeia: ?anioaeeeaineee iaaeaaaeiinoaaiiue na.iao/i. o?oaeia. – Eeaa, “Caei?iacy ” ,1996.-Aui.25.- N.125 – 127. 5.Ne?aiei I.E., A?eaeiaaa I.I., Aaeici?iaa I.E., Oeiaeeeiaa I.A., E?euaiei I.I., Naieiaa E.A., A?uioeiaa N.N., ?iaeiia A.A. Eiioiieiae/aneay oa?aeoa?enoeea aeaoae n ia-oieiaeae aano?iaeoiaeaiaeueiie ciiu n /anoie ?anie?aoi?iie caaieaaaaiinoueth//?in. aeo?-iae. aano?iyioa?ie., aaiaoie., eieiiii?ieoie..-1997.-?5.-O.OI.-N.206. 6.N??aiei I.?., Iaeiaa I.A., A?eici?iaa I.?.,A?eioeiaa N.N.,E??uaiei I.I.,Naieiaa ?.A.,Oeiae?eiaa I.A.,?iaeiia I.I. Iniaeeaino? ?ioiieia?/iiai noaoono oa e?eoaaiiy /anoi oai??th/eo ae?oae i?e ?ioieneeaoe?? OII //Aeooaeuei? i?iaeaie iaaee/ii? iaoee : THa?eaeiee iaoeiaee ca??iee , i?enay/aiee 75- ??//th canioaaiiy O?OE .-Oa?e?a,1998.- N.157 – 161. 7.Naieiaa E.A., Eaiei A.I. O?iaaiue ei?oeciea e AEOA o aeaoae n ?acee/iuie eeeie-/aneeie oi?iaie aoiie/aneiai aea?iaoeoa // Iaoa?eaeu ?ani. iao/ii – i?aeoe/. .eiioa?. “ Aeooaeueiua i?iaeaiu aeaoneie e iiae?inoeiaie yiaeie?eiieiaee”.- Oa?ueeia , 1995.-N.119. 8.Ne?aiei I.E., A?eaeiaaa I.I., Aaeici?iaa I.E., Oeiaeeeiaa I.A., Naieiaa E.A., A?uioeiaa N.N.,E?euaiei I.I., ?iaeiia I.A. Eeeieei-eiioiieiae/aneay oa?aeoa?enoeea /anoi aieathueo aeaoae n iaoieiaeae aano?iaeoiaeaiaeueiie ciiu //Iaoa?eaeu iao/ii - i?aeoe/. eiioa?., iinayuaiiie 75 – eaoeth Oe?.IEEICAeI “ Aeooaeuei? i?ia-eaie ioi?iie caei?iacy ae?oae oe?eueiiai a?eo ? i?aee?oe?a ” .-Oa?e?a, 1997.-N.169-170. 9.Ne?aiei I.E.,Noaea/aa A.Ae., Aaeici?iaa I.E., Naieiaa E.A., A?eaeiaaa I.I., E?euaiei I.I.,A?uioeiaa N.N.,?iaeiia A.A. I?ioeeaeoe/aneay aaeoeeiaoeey /anoi aieathueo aeaoae // Iaoa?eaeu iao/ii – i?aeoe/.eiioa?. , iinayuaiiie 75 – eaoeth Oe?. IEEICAeI “Aeooaeuei? i?iaeaie ioi?iie caei?iacy ae?oae oe?eueiiai a?eo ? i?aee?oe?a”.- Oa?e?a ,1997 .- N.171 – 172. 10.E.i.i.A?eaeiaaa I.I. ,e.i.i. Oeiaeeeiaa I.A.,e.i.i. Aaeici?iaa I.E., e.i.i. A?uioeiaa N.N., e.i.i. ?iaeiia A.A., e.i.i. E?euaiei I.I., ann. Naieiaa E.A. Iiuo ea/aiey aeenaaeoa?eica eeoa/ieea o aeaoae 1 aiaea aeecie a oneiaeyo aeaoneie iieeeeeieee / / Iaoa??aee ?aa?iiaeueii? iaoeiai-i?aeoe/ii? eiioa?aioe?? c i?aeia?iaeiith o/anoth “ Oa?/oaaiiy caei?iai? oa oai?i? aeeoeie ” : Oa?e?a, 19 – 20 ea?oiy 1999 ?. - n.68 - 69. AIIOAOe?ss Naieiaa ?.A. Ee?i?ei – ?ioiieia?/ia oa?aeoa?enoeea ae?oae c ??cieie oi?iaie aoi-i?/iiai aea?iaoeoo oa ?o ?aaa?e?oaoe?y a aiaoeaoi?ii - iie?ee?i?/ieo oiiaao. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?-aeuei?noth 14.01.10 - Iaae?ao??y. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a , 1999. A ?iaio? i?aaenoaaeaii ee?i?ei - ?ioiieia?/io oa?aeoa?enoeeo 114 ae?oae c ??cieie ee?i?/ieie aa??aioaie aoii?/iiai aea?iaoeoo ( AAe ) - aenoaeaoeaiei, i?o?ea?iiciei , a?e-oaiaoicii – neaaiicii –e?oaii?aeiei ? a niieo/aii? c ?ani??aoi?iei aea?aicii. Anoaiiaeaii, ui ia ?icaeoie AAe aieeaathoue niaaeeia? , iaaeeei-a?ieia?/i? , nioe?aeueii – a?a??i?/i? oaeoi?e; o 74.6 % ae?oae aeyaeaii ?ioiiaeao?oeeoiee noai, yeee oa?aeoa?eco?oueny cieaeaiiyi e?eueeino? oa ooieoe?? O- e?ioioeeo?a, e?eueeino? A - e?ioioeeo?a , aeen?ioiiaeiaoe?iai??th ?, I??, V, VII oei?a, ii?ooaiiyi ianiaoeeo?/ieo oaeoi??a caoenoo ; o 66,6% ae?oae aeyaeaii i?eai?/aiiy noi?ani?ii? aeoeaiino? O- e?ioioeeo?a. Cai?iiiiiaaii eiiieaen e?eoaaeueieo caoiae?a c aeeth/aiiyi a aino?ee ia??iae AAe aioa?ini?aaio?a ( EAA –1 , ni?aiaaeue) , a ia??iae ee?i?/ii? ?ai?n?? ( i?ney aeine?aeaeaiiy ?io-iieia?/iiai noaio aeeoeie) ?ioiiei?aeoi?a oeiiaaia. Eeth/ia? neiaa : ae?oe , aoii?/iee aea?iaoeo, aea?ii-?ani??aoi?iee neiae?ii, oaaioeeoic , e?ioioeeo , ?ioiiaeiaoe?ie, O – noi?ani?e , ?aaa?e?oaoe?y, aioa?ini?aaio, ?ioiiei?aeoi?. AIIIOAOeEss Naieiaa E.A. Eeeieei-eiioiieiae/aneay oa?aeoa?enoeea aeaoae n ?acee/iuie oi?ia-ie aoiie/aneiai aea?iaoeoa e eo ?aaaeeeoaoeey a aiaoeaoi?ii - iieeeeeie/aneeo onei-aeyo .-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii aoeeaeue-iinoe 14.01.10. - iaaeeao?ey . Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao . – Oa?ueeia , 1999 a. A aeenna?oaoeee i?aaenoaaeaia eeeieei – eiioiieiae/aneay oa?aeoa?enoeea 114 aeaoae a aic?anoa io 2 aei 14 eao, no?aaeathueo aoiie/aneei aea?iaoeoii (AAe)( aeaai/ae - 63%, iaeue-/eeia – 37 %) .A caaeneiinoe io aic?anoa ?aaaiea e eiaeiuo i?iyaeaiee caaieaaaiey au-aeaeaiu eeeie/aneea aa?eaiou oa/aiey AAe (eeeie/aneea oi?iu) : yennoaeaoeaiue ( 24.5%), i?o?eaeiiciue ( 24.5%), y?eoaiaoicii – neaaiicii – eeoaiieaeiue ( 23.6%) e aea?ii – ?an-ie?aoi?iue neiae?ii ( AAe a ni/aoaiee n ?anie?aoi?iui aeea?aicii) ( 27.4%). Onoaiiaeaii , /oi ia ?acaeoea AAe aeeytho : ianeaaenoaaiiue oaeoi? ( naiaeiay i?aae-?aniieiaeaiiinoue e aeea?ae/aneei caaieaaaieyi )( 60%) ; iaaeeei – aeieiae/aneea oaeoi?u: “ iiaeeeie ” aic?ano ?iaeeoaeae ( 54% ), o?iie/aneea caaieaaaiey ?iaeeoaeae aeaoae n AAe ( caaieaaaiey aa?oieo aeuoaoaeueiuo iooae , aeaeoaei/ii - eeoa/iiai o?aeoa , iaiaiiua , yiaeie?eiiua ),iaoieiaey aa?aiaiiinoe o iaoa?ae (aanoicu ?,?? ieiaeiu , aiaiey ) ( 71%), iaoieiaey ?iaeiaie aeayoaeueiinoe ( 33%),?aiiaa eneonnoaaiiia anea?ieeaaiea aeaoae ( 75%), o?iie/aneea eioaeoeee EI? - i?aaiia e aeaeoaei/ii - eeoa/iiai o?aeoa o aeaoae n AAe ; nioeeaeueii – aeaeaie/aneea oaeoi?u: yeieiae/anee iaaeaaiiieo/iue ?aeii i?iaeeaaiey aea-oae n AAe ( 98% ), iaaeaaii?eyoiua aeeeeuii - auoiaua oneiaey ( 84% ) , i?ioanneiiaeue-iua e auoiaua a?aaeiinoe ?iaeeoaeae aeaoae n AAe . Aeey anao eeeie/aneeo oi?i AAe e Ae?N auee oa?aeoa?iu: yiceiioeeey, iiiioeeoiia-iey a eeeie/aneii aiaeeca e?iae , nieaaie inaaeie a ii/a ( ienaeaou , o?aou, oinoaou) e nieaaay eie?onoaoeey ii/a/iuo eioaiie i?e oeueo?acaoeiaii enneaaeiaaiee ii/ae, iaee/ea iaoiaaiiie iee?ioei?u ( noaoeeieiee , no?aioieiee ) a iiniaeioea . O 75 % aeaoae auyaeaii eiioiiaeaoeoeeoiia ninoiyiea, oa?aeoa?ecothuaany nieaeaieai /enea O - eeioioeeoia , eo ooieoeeiiaeueiie aeoeaiinoe, aeoaieeie naeaeaaie a ?aaoeyoi?iie ooieoeee O – eeioi-oeeoia ( O – noi?anni?ia ) ; aeenneiioiiaeiaoeeiaieyie I , III , V ,VII oeiia , aeiieiioii-aeiaoeeiaieae I ( 70% ) , aeia?eiioiiaeiaoeeiaieae A( 87%) ,aeia?eiioiieiieaenaieae ( 72%) . A ia?eiaea iaino?aiey AAe i?e anao eeeie/aneeo oi?iao iaia?oaeaii o aeaoae ia?ooa-iea oaeoi?ia ianiaoeeoe/aneie ?acenoaioiinoe: nieaeaiea iieacaoaeae oaaioeeoica, nuai?i-oi/iiai eecioeeia, nuai?ioi/iiai eiiieaiaioa. Auyaeaii, /oi iaeaieaa iaaeaaii?eyoiie a eiioiieiae/aneii ieaia yaeyaony a?oiia aeaoae n aea?ii-?anie?aoi?iui neiae?iiii: ?acei nieaeaii eiee/anoai O - eeioioeeoia, eo ooieoeeiiaeueiay aeoeaiinoue, ?acei oaiaoaia oeeoioiene/aneay aeoeaiinoue O - eeioioeeoia (O - noi?anni?ia). ?acoeueoaou enneaaeiaaiey iicaieeee aeiiieieoue o?aaeeoeeiiiue eiiieaen ea/aaiuo ia- ?ii?eyoee i?e AAe (aeiiaeea?aiaaiiay aeeaoa , aioeaenoaieiiua i?aia?aou ei?ioeiai e i?ieiiae?iaaiiiai aeaenoaey, iaia?aiio?iiiua i?aia?aou , naaeaoeaiua n?aaenoaa , oa?-iaioiua i?aia?aou, yoaeioeee , oecei-i?ioeaaeo?u, ianoiay oa?aiey )iacia/aieai a ino-?ue ia?eiae yioa?ini?aaioia ( EAO-I , ni?aiaaeue ) , a a ia?eiae eeeie/aneie ?aiennee ( iinea eco/aiey eiioiieiae/aneiai i?ioeey ?aaaiea n AAe ) eiioiiiiaeoeyoi?a oe-iiaaia. Aeeth/aiea a eiiieaen ea/aiey yioa?ini?aaioia a ia?eiaea iaino?aiey niinianoaoao yeeieiaoeee eiioiiuo eiiieaenia e ainnoaiiaeaieth iieacaoaeae ianiaoeeoe/aneie ei-ioiieiae/aneie caueou ( oaaioeeoica , nuai?ioi/iiai eiiieaiaioa , eecioeeia ) . Iaia?oaeaiiua o aeaoae n AAe aeaoaeou a ?acee/iuo caaiueyo eiioieoaoa yaeeenue iniiaaieai aeey iacia/aiey a ia?eiae ?aiennee eiioiiiiaeoeyoi?a oeiiaaia. Iiae aicaeae-noaeai oeiiaaia i?ienoiaeeea ii?iaeecaoeey ooieoeeiiaeueiie aeoeaiinoe O – eeioioee-oia, oaaee/aiea eiee/anoaa O- noi?anni?ia , ainnoaiiaeaiea eiioii?aaoeyoi?iiai eiaeae-na . I?aaeeiaeaiiue ?aoeeiiaeueiue eiiieaen ianeaaeiaaiey e eiaeeaeaeoaeueiue ea/aaiue iiaeoiae n aeeth/aieai yioa?ini?aaioia a ino?ue ia?eiae caaieaaaiey e oeiiaaia a ia?e- iae eeeie/aneie ?aiennee iicaieee aeinoe/ue eeeie/aneiai oeo/oaiey o 57.8% aeaoae , a oaeaea oiaiueoeoue oyaeanoue oa/aiey AAe , nieceoue /anoioo iaino?aiee e oaaee/eoue aeee-oaeueiinoue eeeie/aneie ?aiennee . Eeth/aaua neiaa : aeaoe, aoiie/aneee aea?iaoeo, aea?ii-?anie?aoi?iue neiae?ii, oaaioee-oic, eeioioeeo, eiioiiaeiaoeeiu, O – noi?anni?u, ?aaaeeeoaoeey, yioa?ini?aaio, eiioii-ei??aeoi?. ABSTRACT Sankova I.G Clinicoimmunologic characteristics of children with various forms of atopic dermatitis , their rehabilitation in out – patient institutions.- Manuscript. Thesis for candidate of medical science degree on speciality 14.01.10 – Pediatrics. Kharkov State Medical University , Kharkov , 1999. The work presents clinicoimmunologic characnteristics of 114 children with different clinical forms of atopic dermatitis ( exudative , pruriginous , erythematic – squamous-lichenoidal and combination with respiratory allergosis ) . It has been established that AD development is influenced by hereditary , medico-biological and socio- hygienic factors. Immunodeficiency characterized by a decrease in T- lymphocytes number and their functionability as well as by B –lymphocytes number reoders , type I , ?II, V and VII dysimmunoglobulinemia , and disorders in non-specific protective factors has been revealed in 74,6% children . In 66,6% of children there has been revealed some inhibition of T – lymphocyte suppressor activity . There has been suggested a set of treatment measures including enterosorbents ( CAC – 1 / concentrat activated carbon – 1/ and sorbogel during acute period) and thymogen as immunocorrector during the period of clinical remission (after studying immunologic profile in the child ) . Key words: children atopic dermatitis , dermorespiratory syndrome, phago-cytosis, lymphocytes, immunoglobulins , T – suppressors , rehabilitation, enterosorbents, immunocorrectors. NIENIE NEI?I*AIUe AAe - aoii?/iee aea?iaoeo Ae?N - aea?ii-?ani??aoi?iee neiae?ii Ig - ?ioiiaeiaoe?i ??? - ?ioii?aaoeyoi?iee ?iaeaen NAe3+ - caaaeuei? O – e?ioioeeoe NAe4+ - O- oaeia?e NAe8+ - oeeoioiene/i? e?ioioeeoe ( O- noi?ani?e) OCAe - oeueo?acaoeiaa aeine?aeaeaiiy Oe?E - oee?eoethth/? ?ioii? eiiieaene

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