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Клініко-гемодинамічні особливості перебігу ішемічної хвороби серця в післяінфарктному періоді під впливом терапії антагоністами кальцію та інгібіторам

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20

OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Ai?iiiaa Iaoae?y Ieeiea?aia

OAeE 616-005.4-085.31-085.225.2:616.127-005.8-06

EE?I?EI-AAIIAeEIAI?*I? INIAEEAINO? IA?AA?AO ?OAI?*II? OAI?IAE NA?Oess A
I?NEss?IOA?EOIIIO IA??IAe? I?Ae AIEEAII OA?AI?? AIOAAII?NOAIE EAEUeOe?TH
OA ?IA?A?OI?AIE AIA?IOAICEIIA?AOAI?THTH*IAI OA?IAIOO

14.01.11 – ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaoiaoc ?aai E?iae?aoiae/, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e aioo??oi?o
oai?ia, EOE oa NI, caneoaeaiee ae?y/ iaoee oa oaoi?ee Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeueiaa Ieueaa Ieeiea?aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?1;

aeieoi? iaaee/ieo iaoe I?eieaiei ?aaai sseiae/, ?inoeooo oa?ai?? AII
Oe?a?ie, i.Oa?e?a, canooiiee aee?aeoi?a ii iaoeia?e ?iaio?

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?iai? aeaaeai?ea I.Ae. No?aaeanea AII Oe?a?ie,
i.Ee?a, a?aeae?e ?ioa?eoo i?iea?aea oa a?aeiiaethaaeueiiai e?eoaaiiy.

Caoeno a?aeaoaeaoueny 27 ea?oiy 2000 ?. i 13-30 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

Aaoi?aoa?ao ?ic?neaiee 2 aa?aciy 2000 ?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?oai?/ia oai?iaa na?oey (?ON) oa ?? iaea?eueo
caa?iceeaa oneeaaeiaiiy – aino?ee ?ioa?eo i?iea?aea (?I) caeeoathoueny
iaei??th c iaea?eueo iioe?aieo i?e/ei nia?o? a aeiiii?/ii ?icaeiooeo
e?a?iao. A?aeaeaeaiee i?iaiic i?ney ?I aecia/a?oueny ?icaeoeii
?a?ioa?eo?a, i?ia?anoaaiiyi ?ON oa na?oeaai? iaaeinoaoiino? (NI), yea
?icaeaa?oueny ia i?ioyc? 5 ?ie?a o 15%-30% oai?eo, ye? ia?aianee ?I
(E.I.Aiiniaa, 1998, H. Ogawa et al., 1994, W.Koenig et al., 1996).

Ai?iaaaeaeaiiy a ee?i?/io i?aeoeeo iiiyooy ?aiiaeaethaaiiy e?aiai
oeoii/ea (EO) na?oey o oai?eo i?ney ?I aecia/eei iiaee i?aeo?ae aei
oa?ai?? NI. Nueiaiaei? ?aiiaeaethaaiiy EO ?icaeyaea?oueny ye aoai o
anoaiiaeaii?, ?icaeoeo oa i?ia?anoaaii? NI (M.A.Pfeffer, E.Braunwald,
1990).

A oe?ieiianooaaieo ee?i?/ieo aeine?aeaeaiiyo aoei ia?aeiieeai iieacaii,
ui ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo (?AIO) e??i
ia?aoeiaeaeaiiy ?icaeoeo ?aiiuei? aeeeaoaoe?? EO a aino?iio ia??iae? ?I
? ?icoe?aiiy eiai ciie, iie?auaiiy ooieoe?? “i?eaeooaiiai” i?iea?aeo,
i?e o?eaaeiio canoinoaaii? a i?ney?ioa?eoiiio ia??iae? ni?eythoue
cieaeaiith eaoaeueiino?, ciaioaiith e?eueeino? ?a?ioa?eo?a oa
i?ia?anoaaiiy NI. An? oe? aoaeoe noaaeyoue ?AIO a ?yae iaea?eueo
ia?niaeoeaieo ea?ae?ieia?/ieo i?aia?ao?a (A.Ae.Neaieai, 1998, S.G.Foy et
al., 1994, M.A.Pfeffer et al., 1997).

I?ney ?I niinoa??aa?oueny aeoeaaoe?y ?ai?i-aia?ioaiceiiai? nenoaie
(?AN), i?e/iio, ye a ?aiiueiio, oae ? a i?ciueiio i?ney?ioa?eoiiio
ia??iae?. Iae?i-aoii?aeueia aeoeaaoe?y yaey? niaith iaoio?c?ieia?/iee
eaioetha i?ae ?I oa ?icaeoeii o?ii?/ii? NI (W.J.Remme et al., 1990).

A?ia?aeoeai?noue ?AN i?ney ?I iiaea aooe ciaioaia ca ?aooiie
oa?iaeieia?/iiai ao?o/aiiy. ?AIO caeiyee i?ia?aeia i?noea a e?eoaaii?
oai?eo c NI i?ney ?I, ia?aoeiaeaeoth/e ?icaeoeo ?aiiaeaethaaiiy EO.
Iacaaaeath/e ia oa, ui oi/iee iaoai?ci ?o iiceoeaiiai aieeao iaa?aeiiee,
?nio? iiaeeea?noue ?ic?iaee a?eueo aoaeoeaieo no?aoaa?e i?eai?/aiiy
iae?i-aoii?aeueii? aeoeaiino? i?ney ?I (J.N.Cohn, 1995, T.Omland et al.,
1993, M.P.Schlaich, R.E.Schmieder, 1998).

Iieeaaeathoueny oaeiae iaae?? ia ii?aeiaiiy ?AIO c aioaaii?noaie
eaeueoe?y. Oae? iiceoeai? aoaeoe aioaaii?no?a eaeueoe?y, ye cieaeaiiy
i?neyiaaaioaaeaiiy a ii?aeiaii? c iiooaeiith aaciaeeeaoaoe?eiith ae??th,
oai?aoe/ii aaaaoiia?oeyth/? a oa?ai?? NI, a iaaaoeai? aoaeoe, ui
iia’ycai? c iae?iaoii?aeueiith aeoeaaoe??th, iiaeooue aooe caaeainiaai?
?AIO (J.F.Hansen et al., 1997). Iaeiae, aeai? a i?aeo?eieo oaeiai
iaa?oiooaaiiy iaei/enaeuei?, a aieea aeaii? oa?ai?? ia iieacieee, ui
oa?aeoa?ecothoue ooieoe?th ?AN oa aaiiaeeiai?/i? ia?aiao?e ?
iaaeinoaoiuei aea/aiei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iaoa??aee
aeena?oaoe?? aeieeaathoue c ieaiiaeo iaoeiai-aeine?aeieo ?ia?o
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. Aeena?oaoe?eia
?iaioa ? neeaaeiaith /anoeiith iaoeiai-aeine?aeii? ?iaioe “Iaoieia?y
na?oeaai-noaeeiii? nenoaie” ? Aea?ae. ?a?no?aoe?? 0195002346 2.

Iaoa aeine?aeaeaiiy. ?ic?iaea aeeoa?aioe?eiaaieo noai e?eoaaiiy c
aeei?enoaiiyi ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? ia iniia?
aea/aiiy ee?i?/ii? aoaeoeaiino?, aieeao ia aaiiaeeiai?eo, noai ?AN oa
ai?no aeaeo?ie?o?a ieacie e?ia? o oai?eo ?ON, ui ia?aianee aino?ee ?I,
ye? iai?aaeai? ia iie?auaiiy ia?aa?ao oa i?iaiico caoai?thaaiiy.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe aieea o?eaaei? oa?ai?? ?AIO, aioaaii?noaie eaeueoe?y oa ?o
eiia?iaoe?? ia aaiiaeeiai?/i? ia?aiao?e oa aeaeo?iea?ae?ia?ao?/i?
iieacieee o oai?eo ?ON, ye? ia?aianee aino?ee ?I.

2. Aecia/eoe iiaeeeaee ca’ycie ci?i AEA c aaiiaeeiai?/ieie iieacieeaie
oa ee?i?/iei ia?aa?aii caoai?thaaiiy.

3. Aea/eoe aeeiai?eo iieaciee?a, ye? oa?aeoa?ecothoue aeoeai?noue ?AN
(?ai?i, aia?ioaicei II), a oaeiae ai?no aeaeo?ie?o?a a ieaci? e?ia? i?ae
aieeaii ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe??.

4. Anoaiiaeoe iiaeeeaee ca’ycie i?ae oa?aiaaoe/iei aoaeoii ?AIO,
aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? c aieeaii ia ?aaoeyoi?i?
nenoaie, ui aea/aeenue a aeine?aeaeaii?.

5. Ii??aiyoe a?aeaeaeaio (ia i?ioyc? 1-ai ?ieo) ee?i?/io aoaeoeai?noue
oa aacia/i?noue oa?ai?? ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? o
oai?eo ?ON, ye? ia?aianee ?I, oa aieea oa?ai?? ia a?aeaeaeaiee i?iaiic
caoai?thaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iieacaia iiaeeea?noue
ia?aoeiaeaeaiiy i?ioeanai ?aiiaeaethaaiiy EO i?ney ia?aianaiiai ?I i?ae
aieeaii oa?ai?? ?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y, aea
ia oa?ai?? o?eueee aioaaii?noaie eaeueoe?y. Anoaiiaeaii ca’ycie i?ae
ia?aoeiaeaeaiiyi i?ioeanai ?aiiaeaethaaiiy EO oa cieaeaiiyi aeoeaiino?
?AN i?ae aieeaii oa?ai?? ?AIO (ca ?aooiie cieaeaiiy ai?noo aia?ioaiceia
II) oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y (ca ?aooiie cieaeaiiy
ai?noo aia?ioaiceia II ? aeoeaiino? ?ai?ia ieacie). Anoaiiaeaii, ui
o?eaaea oa?ai?y ?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y o
oai?eo, ye? ia?aianee ?I, iaeiaeiai aoaeoeaia aeey caiia?aaiiy
i?ia?anoaaiiy NI ? noaiiea?ae??, a eiia?iiaaia oa?ai?y ?AIO c
aioaaii?noaie eaeueoe?y i?eaiaeeoue aei a?eueoiai cieaeaiiy /anoioe
i?ia?anoaaiiy NI, ?a?ioa?eoa ? nia?o?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaii, ui oa?ai?y
eaioii?eeii, aiaeai?eeii oa aiaeai?eeii a ii?aeiaii? c aaeaeaoii SL
aoaeoeaia o oai?eo c noaiiea?ae??th, ui aeieea? i?ney ?I, a aiaeai?eeii
a ii?aeiaii? c aaeaeaoii SL – o iaoe??io?a c aenieei ?eceeii ?icaeoeo
nia?o?, NI oa/aai ?a?ioa?eoa. Oa?ai?y o?eueee aaeaeaoii SL iiaea aooe
?aeiiaiaeiaaia iaoe??ioai c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy oa
ni?eyoeeaei i?iaiicii.

Aeyaeaii, ui canoinoaaiiy aaeaeaoa SL ? eaioii?eea i?eaiaeeoue aei
a?aeiinii? noaa?e?caoe?? aaiiaeeiai?ee, aiaeai?eea – aei cieaeaiiy
e?ioeaai-nenoie?/iiai ia’?io (ENI) EO, a i?ecia/aiiy eiia?iiaaii?
oa?ai?? aiaeai?eeii oa aaeaeaoii SL – aei cieaeaiiy ENI,
e?ioeaai-ae?anoie?/iiai ia’?io (EAeI) ? i?aeaeuaiiy o?aeoe?? aeeeaeo
(OA) EO.

Iieacaii iiaeeea?noue cieaeaiiy a?ia?aeoeaiino? ?AN i?ae aieeaii oa?ai??
?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y. Iaea?eueoiai aoaeoo
aaea?oueny aeiaeoeny i?e canoinoaaii? eiia?iiaaii? oa?ai?? aiaeai?eeii ?
aaeaeaoii SL, yea, e??i oiai, ia noi?iaiaeaeo?oueny ci?iaie
aeaeo?ie?oiiai aaeaino.

Aeai?, io?eiai? i?e aeeiiaii? ?iaioe, aeei?enoai? a iaaeaaia?/iiio
i?ioean? ia eaoaae?? aioo??oi?o oai?ia, EOE oa NI Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. ?ic?iaeaio aeeoa?aioe?eio noaio
e?eoaaiiy oai?eo ?ON, ui ia?aianee aino?ee ?I, ai?iaaaeaeaii a i?aeoeeo
?iaioe aei?iaeiuei? ee?i?/ii? e?ea?i? ?2 ICAe oa i?nueei? ee?i?/ii?
e?ea?i? ?27 i. Oa?eiaa, Aea?aa/?anueei? oeaio?aeueii? ee?i?/ii?
e?ea?i?, Ciei/?anueei? oeaio?aeueii? ?aeiiii? e?ea?i?, ?aeiiii?
iie?ee?i?ee ?9 i. Oa?eiaa, a ?acoeueoao? aeinyaiooi iie?auaiiy i?iaiico
caoai?thaaiiy, cieaeaiiy /anoioe oaeeo ee?i?/ii aaaeeeaeo iiae?e, ye
nia?oue, ?a?ioa?eo oa i?ia?anoaaiiy na?oeaai? iaaeinoaoiino?.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai iniaenoi i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a ii i?iaeai?, ui aea/aeanue, i?iaaaeaii
ee?i?ei-?ino?oiaioaeueia ianoaaeaiiy a oiio /ene? oeueo?acaoeiaa
ianoaaeaiiy oa ia?iaea aeaieo aeaeo?iea?ae?ia?ao?? c aeei?enoaiiyi
i?ea?iaeueii? iaoiaeeee. ?ic?iaeaia noaia aeeoa?aioe?eiaaiiai
i?ecia/aiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo aiaeai?eea
iaeaaoii ? eaioii?eeii oa aioaaii?noa eaeueoe?th aaeaeaoa SL a
caeaaeiino? a?ae ia?aa?ao i?ney?ioa?eoiiai ia??iaeo. Aaoi?ii i?iaaaeaia
noaoenoe/ia ia?iaea ? aiae?c io?eiaieo ?acoeueoao?a c aeei?enoaiiyi
no/anieo iaoaiaoe/ieo iaoiae?a oa eiii’thoa?ii? oaoi?ee. Caeiaoaa/ai
naiino?eii iaienai? an? ?icae?ee ?iaioe, noi?ioeueiaaii aeniiaee oa
i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny oa iaaiai?thaaeeny ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
iieiaeeo a/aieo (Oa?e?a, 1996, 1997), can?aeaiiyo Oa?e?anueeiai
iaoeiai-iaaee/iiai oiaa?enoaa (Oa?e?a, 1998), XIV c’?cae? oa?aiaao?a
Oe?a?ie (Ee?a, 1998), iaoeiai-i?aeoe/i?e eiioa?aioe?? “Iia? ai?eciioe
ee?i?ee aioo??oi?o caoai?thaaiue” (Oa?e?a, 1998).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 6 ?ia?o (4 noaoo? o
iaoeiaeo aeo?iaeao oa 2 noaoo? a ca??ieeao iaoeiaeo i?aoeue).

No?oeoo?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia 153
noi??ieao ae?oeiaaiiai oaenoo, ?ethno?iaai? 9 iaethieaie oa 9 oaaeeoeyie
(ui neeaaea? 15 noi??iie) ? neeaaeathoueny c? anooio, iaeyaeo
e?oa?aoo?e, 5 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e. Nienie aeei?enoaii? e?oa?aoo?e i?noeoue 191
aeaea?aei (ui neeaaea? 25 noi??iie), c yeeo 37 a?o/eciyieo oa 154
ca?oa?aeieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

A ianoaaeaiiy aoei aeeth/aii 120 oai?eo ?ON, ye? ia?aianee aino?ee ?I
oa ciaoiaeeeeny i?ae iaaeyaeii a ?aeiiieo iie?ee?i?eao ? 27 ? 28
i.Oa?eiaa a ia??iae c 1996 ii 1998 ?iee.

Ae?aaiic ?I aenoaaeyany c o?aooaaiiyi e?eoa???a AIIC. Ia?aa?a aino?iai
ia??iaeo ?I (oneeaaeiaiee, iaoneeaaeiaiee) ioe?ithaaee ca?aeii
?aeiiaiaeaoe?e E.Braunwald, 1993.

Oai?eo ianoaaeoaaee /a?ac 1, 3, 6 oa 12 i?nyoe?a a?ae ii/aoeo ?I.
Ianoaaeaiiy aeeth/aei ioe?ieo ee?i?/ieo, ?ino?oiaioaeueieo oa
eaai?aoi?ieo ia?aiao??a.

Ae?aaiic noaiiea?ae??, ?? oa?aeoa? oa ooieoe?iiaeueiee eean (OE)
anoaiiaethaaee ca?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie AIEOe AII N?N?
(1983), ?ic?iaeaieo ia i?aenoaa? e?eoa???a AIIC 1979 ?. Aeey ioe?iee
nooiaiy NI aeei?enoiaoaaee eeaneo?eaoe?th o?ii?/ii? na?oeaai?
iaaeinoaoiino? Iueth-Ei?enueei? anioe?aoe?? ea?ae?ieia?a (NYHA, 1973).

?a?no?aoe?th AEA niieith i?iaiaeeee a 12 noaiaea?oieo a?aeaaaeaiiyo c
aeei?enoaiiyi i?e iaiao?aeiino? aeiaeaoeiaeo a?aeaaaeaiue. I?e oeueiio
ioe?ithaaee noai naaiaioo ST AEA (ia ?cie?i??/aeaaaoe?y) oa coaoey O
(iiceoeaiee/iaaaoeaiee). I?iaiaeeee aiae?c e?ioeaai? /anoeie
oeoii/eiaiai eiiieaeno AEA c o?aooaaiiyi ?aeiiaiaeaoe?e Kusniec J. et
al., 1997. O oai?eo c ia?aaei?i ?I aeae?eyee 4 oeie AEA: oei A (ST ia
?cie?i??, O iaaaoeaiee); oei A (aeaaaoe?y ST, O iaaaoeaiee); oei N (ST
ia ?cie?i??, O iiceoeaiee); oei D (aeaaaoe?y ST, O iiceoeaiee).

Aeine?aeaeaiiy nei?ioeeai? caeaoiino? i?iea?aea ? ia?aiao??a
aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii aoiea?ae?ia?ao?? ca aeiiiiiaith
aia?aoa “Aloka SSD-280” (ssiii?y) oa OE-628 (Oe?a?ia) /a?ac 1 oa 12
i?nyoe?a i?ney ia?aianaiiai aino?iai ?I. I?e oeueiio ?ic?aoiaoaaee oae?
iieacieee, ye ENI, EAeI ? OA EO.

Aecia/aiiy ai?noo eae?y oa iao??y a ieaci? e?ia? i?iaiaeeee iaoiaeii
iieoi’yii? oioiiao???.

E?euee?nia aecia/aiiy ai?noo aia?ioaiceia II oa aeoeai?noue ?ai?ia a
ieaci? e?ia? i?iaiaeeee ?aae?i?ioiieia?/iei iaoiaeii ca aeiiiiiaith
iaai??a o??ie DRG (NOA) aeey aia?ioaiceia II oa o??ie SB-REN2 (O?aioe?y)
aeey ?ai?ia. An? ?aaeoeae aeei?enoiaoaaeenue ca?aeii ?ino?oeoe?? aeey
i?iaaaeaiiy aiae?c?a.

Noaoenoe/ia ia?iaea aeaieo i?iaiaeeeanue ca?aeii i?aaee ia?iaee
iaaee/ii-a?ieia?/ii? ?ioi?iaoe?? ca aeiiiiiaith noaoenoe/ii? i?ia?aie
STATISTICA FOR WINDOWS (StatSoft, NOA). An? io?eiai? aeai? iiaeaii o
aeaeyae? na?aaeiueiai a?eoiaoe/iiai (I) eiai noaiaea?oia aeaa?aoe?y
(SD).

?acoeueoaoe aeanieo aeine?aeaeaiue

Na?aae ianoaaeaieo 120 oai?eo aoei 90 /ieia?e?a oa 30 ae?iie
(ni?aa?aeiioaiiy /ieia?ee/ae?iee neeaei 3:1), na?aaei?e a?e 55,45,2
?iee.

Aiae?c aiaiianoe/ieo aeaieo iieacaa, ui o 42 (35%) iaoe??io?a ?I aoa
ia?oei ee?i?/iei i?iyaii ?ON. Noaiiea?ae?th ??cieo ooieoe?iiaeueieo
eean?a iaee 52 (43,3%) iaoe??ioe, o 26 oai?eo aei iiyae ?I aeyaeyany
ia??iae aeanoaa?e?caoe?? noaiiea?ae?? (ca?eueoaiiy /anoioe aai ci?ia
oa?aeoa?o aieueiaeo i?enooi?a, i?aeaeuaiiy i?eeiio ? oiea?aioiino? aei
i?o?iae?oea?eio), i?e/iio o 13 (10,8%) – aia?oa aeyaeaii?. ?I a
aiaiiac? a?aei?/aany o 13 (10,8%) c 120 iaoe??io?a. A?oa??aeueia
a?ia?oaic?y aeyaeyeanue o 67 (55,8%) oai?eo, oeoe?iaee ae?aaao – o 11
(9,2%) iaoe??io?a: o 10 – II oeio ? o 1 – I oeio. Caoai?thaaiiy
ia?eoa??eieo noaeei iaee 6 (5%) iaoe??io?a. I?aeaeuaia iana o?ea
a?aei?/aeanue o 21 (17,5%) oai?eo, 52 (43,3%) iaoe??io?a iaeeee.

Ia?aaeith eieae?caoe?th ?I (aeaaaoe?y naaiaioa ST oa/aai iayai?noue
coaoey Q o a?aea?aeaiiyo I, II, avL, v1-v4) aeyaeee o 72 (60%),
caaeiuei-ae?ao?aaiaeueiee (aeaaaoe?y naaiaioa ST oa/aai iayai?noue
coaoey Q o a?aea?aeaiiyo II, III, avF) – o 42 (35%), ia?aaeiuei-caaeith
(aeaaaoe?y naaiaioa ST oa/aai iayai?noue coaoey Q o a?aea?aeaiiyo II,
III, avF, v3-v5) – o 6 (5%) oai?eo. Ii aeeaei? o?aaeaiiy na?oeaaiai
i’yca o 84 (70%) ?I aoa o?ainio?aeueiei, o 36 (30%) – aaeeeiaiaieuaaei.

Oneeaaeiaiee ia?aa?a aino?iai ?I (?aoeeaeea aieth aai ?I, iaa?ye
eaaaiue, ea?ae?iaaiiee oie, ?inoeueo) a?aei?/aany o 62 (51,7%), ia
oneeaaeiaiee – o 58 (48,3%) oai?eo.

Ia 30-oo aeiao ?I noaiiea?ae?y a?aei?/aeanue o 19 (15,8%) iaoe??io?a; NI
I eeano – o 86 (71,1%) oai?eo; II eeano – o 25 (20,8%); III eeano – o 6
(5%); IV eeano – o 3 (2,5%) oai?eo.

I?e aiae?c? aeaieo AEA ci?ie oeio A ?a?no?oaaeeny o 29 (40,3%), oeio A –
o 13 (18,1%), oeio N – o 10 (13,9%), oeio D – o 20 (27,7%) iaoe??io?a.
Aeaii??ia aoiea?ae?ia?ao?y aeicaieeea aeyaeoe ciie an?ia?a?? i?iea?aea o
112 (93,3%) iaoe??io?a. Ioe?iea noaio aaiiaeeiai?ee iieacaea, ui
na?aaei?e EAeI EO o ianoaaeaieo oai?eo neeaa 95,926,3 ie, ENI EO –
46,616,3 ie ? OA EO – 52,615,7%. Aeai? aeaii??ii? aoiea?ae?ia?ao??
i?aeoaa?aeeee oi?ioaaiiy aino?i? i?ney?ioa?eoii? aiaa?ecie EO o 13
(10,8%) oai?eo.

An? oai?? a caeaaeiino? a?ae oeio oa?ai??, yea i?iaiaeeeany ia i?ioyc?
ianooiiiai i?ney ia?aianaiiai ?I ?ieo aeiaaeeiaei /eiii aoee ?icae?eai?
ia 4 a?oie, a eiaeio c yeeo aa?eoee ii 30 iaoe??io?a. Oai?? a a?oi? 1
iaea?aeoaaee eaioii?ee a aeic? 12,5 ia ia aeiao, a a?oi? 2 – aaeaeao SL
a aeic? 40 ia ia aeiao, a a?oi? 3 – aiaeai?ee a aeic? 10 ia ia aeiao, a
a?oi? 4 – eiia?iaoe?th aiaeai?eea a aeic? 10 ia ia aeiao ? aaeaeaoa SL a
aeic? 40 ia ia aeiao. A?oie aoee ii??aiyi? ii iniiaiei
ee?i?ei-aeaiia?ao?/iei iieacieeai.

Ia 30-oo aeiao ?I a a?oi? 1 i?ney?ioa?eoia noaiiea?ae?y niinoa??aaeanue
o 4 (13,3%) iaoe??io?a, NI > II eeano – o 8 (26,3%) iaoe??io?a. A a?oi?
2 i?ney?ioa?eoia noaiiea?ae?y aoea aeyaeaia o 3 (10%) iaoe??io?a, NI >
II eeano – o 7 (23,3%). A a?oi? 3 i?ney?ioa?eoia noaiiea?ae?y
a?aei?/aeanue o 6 (20%) iaoe??io?a, NI > II eeano – o 10 (33,3%). A
a?oi? 4 i?ney?ioa?eoia noaiiea?ae?y niinoa??aaeanue o 6 (20%)
iaoe??io?a, NI > II eeano – o 9 (30%) iaoe??io?a (a?aei?ie i?ae a?oiaie
iaa??ia?aei?).

*a?ac 3 i?nyoe? a?ae ii/aoeo ?I /anoioa i?ecia/aiiy noiooiuei? oa?ai??
(i?o?aoe, ae?o?aoeee, aaoa-aae?aiiaeieaoi?e oa ?o ii?aeiaiiy) a a?oi? 1
neeaea 53,3%; a a?oi? 2 – 66,7%; a a?oi? 3 – 43,3% ? a a?oi? 4 – 26,7%
(p II eeano10 (33,3)16 (53,3) *9 (30)8 (26,7) ‡Noiooiy oa?ai?y8
(28,5) ?24 (88,9)8 (27,5) ?4 (13,8) ?Oneeaaeiaiee ia?aa?a caoai?thaaiiy

8 (26,7) ‡

16 (53,3)

6 (20) §

2 (6,7) §¶I?ei?oee:

1. A /enaeueieeo iiaeaii caaaeueio e?euee?noue oai?eo a a?oi?, a o
ciaiaiieeo – e?euee?noue oai?eo, ye? cae?i/eee aeine?aeaeaiiy.

2. * – p0.20) i?e a??ia?aeiiio ca?eueoaii?
cia/aiue ENI aei 67,314,2 ie, (a?aei?ie a??ia?aei? ii??aiyii ?c
cia/aiiyie /a?ac 1 i?nyoeue, p0.2. A a?oi? 3 i?e e?eoaaii? aiaeai?eeii
e?euee?noue “iani?eyoeeaeo” AEA a??ia?aeii ciaioeeanue c 50% (9
iaoe??io?a) aei 11,1% (2 iaoe??ioe), p2 nooiaith ii eeaneo?eaoe??
NYHA), oneeaaeiaiee ia?aa?a i?ney?ioa?eoiiai ia??iaeo oa /anoioa
i?ecia/aiiy aeiaeaoeiaeo a?oi oa?iaeieia?/ieo i?aia?ao?a (i?o?ao?a,
aaoa-aae?aiiaeieaoi??a ? ae?o?aoee?a).

I?e ii/aoeo i?ecia/aiiy iaeiiai c aa??aio?a o?eaaei? oa?ai?? (/a?ac 1
i?nyoeue a?ae ?icaeoeo aino?iai ?I) a?oie ia a?ae??ciyeenue ii iniiaiei
ee?i?ei-aiaiianoe/iei oa?aeoa?enoeeai.

Ioe?iea ee?i?/ieo aeaieo o ianoaaeaieo iaoe??io?a /a?ac 3 i?nyoe? a?ae
?icaeoeo aino?iai ?I iieacaea, ui noaiiea?ae?y a 1-e a?oi? oai?eo, ye?
e?eoaaeenue ?AIO, niinoa??aaeanue o 14 (23,3%) iaoe??io?a, iciaee
cano?eii? na?oeaai? iaaeinoaoiino? – o 18 (30%) iaoe??io?a. *anoioa
i?ecia/aiiy aeiaeaoeiaiai e?eoaaiiy a iniiaiiio c-ca ?icaeoeo
noaiiea?ae??, NI aai ii?ooaiue na?oeaaiai ?eoio /a?ac 3 i?nyoe?
niinoa?aaeaiiy a 1-e a?oi? neeaea 48,3% (29 oai?eo).

Oneeaaeiaiee ia?aa?a i?ney?ioa?eoiiai ia??iaeo aeeth/aa iayai?noue oaeeo
ee?i?/ii aaaeeeaeo iiae?e, ye i?ia?anoaaiiy NI, ?a?ioa?eo ? nia?oue, oe?
oneeaaeiaiiy aoee ia’?aeiai? ana?aaeei? a?oi. A ?acoeueoao?, a a?oi? 1
oaeee ia?aa?a caoai?thaaiiy aoei a?aei?/aii a 8 oai?eo 1-? a?oie (13,3%
aeiaaee?a).

A 2-e a?oi? iaoe??io?a, ye? io?eioaaee ii?aeiaio oa?ai?th aiaeai?eeii ?
aaeaeaoii SL, e?euee?noue oai?eo c iayai?noth noaiiea?ae?? oa iciae NI
i?aeoe/ii ia a?ae??ciyeanue, oa neeaea 23,3% (7 iaoe??io?a) ? 9 (30%)
oai?eo, a?aeiia?aeii.

A a?oi? 2 /a?ac 3 i?nyoe? a?ae ii/aoeo i?iaaaeaiiy oa?ai?? a?aei?/aii
oaiaeaioe?th aei cieaeaiiy /anoioe oneeaaeiaiue oa a??ia?aeii iaioa
/anoioa i?ecia/aiiy aeiaeaoeiai? oa?ai??, yeo iio?aaoaaee 8 (26,7%)
oai?eo, p0.2; a a?oiia ea/aiiuo
yiaeai?eeii – n 50.0% aei 11.1%, p

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