20

OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Ai?iiiaa Iaoae?y Ieeiea?aia

OAeE 616-005.4-085.31-085.225.2:616.127-005.8-06

EE?I?EI-AAIIAeEIAI?*I? INIAEEAINO? IA?AA?AO ?OAI?*II? OAI?IAE NA?Oess A
I?NEss?IOA?EOIIIO IA??IAe? I?Ae AIEEAII OA?AI?? AIOAAII?NOAIE EAEUeOe?TH
OA ?IA?A?OI?AIE AIA?IOAICEIIA?AOAI?THTH*IAI OA?IAIOO

14.01.11 — ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaoiaoc ?aai E?iae?aoiae/, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e aioo??oi?o
oai?ia, EOE oa NI, caneoaeaiee ae?y/ iaoee oa oaoi?ee Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeueiaa Ieueaa Ieeiea?aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?1;

aeieoi? iaaee/ieo iaoe I?eieaiei ?aaai sseiae/, ?inoeooo oa?ai?? AII
Oe?a?ie, i.Oa?e?a, canooiiee aee?aeoi?a ii iaoeia?e ?iaio?

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?iai? aeaaeai?ea I.Ae. No?aaeanea AII Oe?a?ie,
i.Ee?a, a?aeae?e ?ioa?eoo i?iea?aea oa a?aeiiaethaaeueiiai e?eoaaiiy.

Caoeno a?aeaoaeaoueny 27 ea?oiy 2000 ?. i 13-30 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

Aaoi?aoa?ao ?ic?neaiee 2 aa?aciy 2000 ?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?oai?/ia oai?iaa na?oey (?ON) oa ?? iaea?eueo
caa?iceeaa oneeaaeiaiiy – aino?ee ?ioa?eo i?iea?aea (?I) caeeoathoueny
iaei??th c iaea?eueo iioe?aieo i?e/ei nia?o? a aeiiii?/ii ?icaeiooeo
e?a?iao. A?aeaeaeaiee i?iaiic i?ney ?I aecia/a?oueny ?icaeoeii
?a?ioa?eo?a, i?ia?anoaaiiyi ?ON oa na?oeaai? iaaeinoaoiino? (NI), yea
?icaeaa?oueny ia i?ioyc? 5 ?ie?a o 15%-30% oai?eo, ye? ia?aianee ?I
(E.I.Aiiniaa, 1998, H. Ogawa et al., 1994, W.Koenig et al., 1996).

Ai?iaaaeaeaiiy a ee?i?/io i?aeoeeo iiiyooy ?aiiaeaethaaiiy e?aiai
oeoii/ea (EO) na?oey o oai?eo i?ney ?I aecia/eei iiaee i?aeo?ae aei
oa?ai?? NI. Nueiaiaei? ?aiiaeaethaaiiy EO ?icaeyaea?oueny ye aoai o
anoaiiaeaii?, ?icaeoeo oa i?ia?anoaaii? NI (M.A.Pfeffer, E.Braunwald,
1990).

A oe?ieiianooaaieo ee?i?/ieo aeine?aeaeaiiyo aoei ia?aeiieeai iieacaii,
ui ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo (?AIO) e??i
ia?aoeiaeaeaiiy ?icaeoeo ?aiiuei? aeeeaoaoe?? EO a aino?iio ia??iae? ?I
? ?icoe?aiiy eiai ciie, iie?auaiiy ooieoe?? “i?eaeooaiiai” i?iea?aeo,
i?e o?eaaeiio canoinoaaii? a i?ney?ioa?eoiiio ia??iae? ni?eythoue
cieaeaiith eaoaeueiino?, ciaioaiith e?eueeino? ?a?ioa?eo?a oa
i?ia?anoaaiiy NI. An? oe? aoaeoe noaaeyoue ?AIO a ?yae iaea?eueo
ia?niaeoeaieo ea?ae?ieia?/ieo i?aia?ao?a (A.Ae.Neaieai, 1998, S.G.Foy et
al., 1994, M.A.Pfeffer et al., 1997).

I?ney ?I niinoa??aa?oueny aeoeaaoe?y ?ai?i-aia?ioaiceiiai? nenoaie
(?AN), i?e/iio, ye a ?aiiueiio, oae ? a i?ciueiio i?ney?ioa?eoiiio
ia??iae?. Iae?i-aoii?aeueia aeoeaaoe?y yaey? niaith iaoio?c?ieia?/iee
eaioetha i?ae ?I oa ?icaeoeii o?ii?/ii? NI (W.J.Remme et al., 1990).

A?ia?aeoeai?noue ?AN i?ney ?I iiaea aooe ciaioaia ca ?aooiie
oa?iaeieia?/iiai ao?o/aiiy. ?AIO caeiyee i?ia?aeia i?noea a e?eoaaii?
oai?eo c NI i?ney ?I, ia?aoeiaeaeoth/e ?icaeoeo ?aiiaeaethaaiiy EO.
Iacaaaeath/e ia oa, ui oi/iee iaoai?ci ?o iiceoeaiiai aieeao iaa?aeiiee,
?nio? iiaeeea?noue ?ic?iaee a?eueo aoaeoeaieo no?aoaa?e i?eai?/aiiy
iae?i-aoii?aeueii? aeoeaiino? i?ney ?I (J.N.Cohn, 1995, T.Omland et al.,
1993, M.P.Schlaich, R.E.Schmieder, 1998).

Iieeaaeathoueny oaeiae iaae?? ia ii?aeiaiiy ?AIO c aioaaii?noaie
eaeueoe?y. Oae? iiceoeai? aoaeoe aioaaii?no?a eaeueoe?y, ye cieaeaiiy
i?neyiaaaioaaeaiiy a ii?aeiaii? c iiooaeiith aaciaeeeaoaoe?eiith ae??th,
oai?aoe/ii aaaaoiia?oeyth/? a oa?ai?? NI, a iaaaoeai? aoaeoe, ui
iia’ycai? c iae?iaoii?aeueiith aeoeaaoe??th, iiaeooue aooe caaeainiaai?
?AIO (J.F.Hansen et al., 1997). Iaeiae, aeai? a i?aeo?eieo oaeiai
iaa?oiooaaiiy iaei/enaeuei?, a aieea aeaii? oa?ai?? ia iieacieee, ui
oa?aeoa?ecothoue ooieoe?th ?AN oa aaiiaeeiai?/i? ia?aiao?e ?
iaaeinoaoiuei aea/aiei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iaoa??aee
aeena?oaoe?? aeieeaathoue c ieaiiaeo iaoeiai-aeine?aeieo ?ia?o
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. Aeena?oaoe?eia
?iaioa ? neeaaeiaith /anoeiith iaoeiai-aeine?aeii? ?iaioe “Iaoieia?y
na?oeaai-noaeeiii? nenoaie” ? Aea?ae. ?a?no?aoe?? 0195002346 2.

Iaoa aeine?aeaeaiiy. ?ic?iaea aeeoa?aioe?eiaaieo noai e?eoaaiiy c
aeei?enoaiiyi ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? ia iniia?
aea/aiiy ee?i?/ii? aoaeoeaiino?, aieeao ia aaiiaeeiai?eo, noai ?AN oa
ai?no aeaeo?ie?o?a ieacie e?ia? o oai?eo ?ON, ui ia?aianee aino?ee ?I,
ye? iai?aaeai? ia iie?auaiiy ia?aa?ao oa i?iaiico caoai?thaaiiy.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe aieea o?eaaei? oa?ai?? ?AIO, aioaaii?noaie eaeueoe?y oa ?o
eiia?iaoe?? ia aaiiaeeiai?/i? ia?aiao?e oa aeaeo?iea?ae?ia?ao?/i?
iieacieee o oai?eo ?ON, ye? ia?aianee aino?ee ?I.

2. Aecia/eoe iiaeeeaee ca’ycie ci?i AEA c aaiiaeeiai?/ieie iieacieeaie
oa ee?i?/iei ia?aa?aii caoai?thaaiiy.

3. Aea/eoe aeeiai?eo iieaciee?a, ye? oa?aeoa?ecothoue aeoeai?noue ?AN
(?ai?i, aia?ioaicei II), a oaeiae ai?no aeaeo?ie?o?a a ieaci? e?ia? i?ae
aieeaii ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe??.

4. Anoaiiaeoe iiaeeeaee ca’ycie i?ae oa?aiaaoe/iei aoaeoii ?AIO,
aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? c aieeaii ia ?aaoeyoi?i?
nenoaie, ui aea/aeenue a aeine?aeaeaii?.

5. Ii??aiyoe a?aeaeaeaio (ia i?ioyc? 1-ai ?ieo) ee?i?/io aoaeoeai?noue
oa aacia/i?noue oa?ai?? ?AIO, aioaaii?no?a eaeueoe?y oa ?o eiia?iaoe?? o
oai?eo ?ON, ye? ia?aianee ?I, oa aieea oa?ai?? ia a?aeaeaeaiee i?iaiic
caoai?thaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iieacaia iiaeeea?noue
ia?aoeiaeaeaiiy i?ioeanai ?aiiaeaethaaiiy EO i?ney ia?aianaiiai ?I i?ae
aieeaii oa?ai?? ?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y, aea
ia oa?ai?? o?eueee aioaaii?noaie eaeueoe?y. Anoaiiaeaii ca’ycie i?ae
ia?aoeiaeaeaiiyi i?ioeanai ?aiiaeaethaaiiy EO oa cieaeaiiyi aeoeaiino?
?AN i?ae aieeaii oa?ai?? ?AIO (ca ?aooiie cieaeaiiy ai?noo aia?ioaiceia
II) oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y (ca ?aooiie cieaeaiiy
ai?noo aia?ioaiceia II ? aeoeaiino? ?ai?ia ieacie). Anoaiiaeaii, ui
o?eaaea oa?ai?y ?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y o
oai?eo, ye? ia?aianee ?I, iaeiaeiai aoaeoeaia aeey caiia?aaiiy
i?ia?anoaaiiy NI ? noaiiea?ae??, a eiia?iiaaia oa?ai?y ?AIO c
aioaaii?noaie eaeueoe?y i?eaiaeeoue aei a?eueoiai cieaeaiiy /anoioe
i?ia?anoaaiiy NI, ?a?ioa?eoa ? nia?o?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaii, ui oa?ai?y
eaioii?eeii, aiaeai?eeii oa aiaeai?eeii a ii?aeiaii? c aaeaeaoii SL
aoaeoeaia o oai?eo c noaiiea?ae??th, ui aeieea? i?ney ?I, a aiaeai?eeii
a ii?aeiaii? c aaeaeaoii SL – o iaoe??io?a c aenieei ?eceeii ?icaeoeo
nia?o?, NI oa/aai ?a?ioa?eoa. Oa?ai?y o?eueee aaeaeaoii SL iiaea aooe
?aeiiaiaeiaaia iaoe??ioai c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy oa
ni?eyoeeaei i?iaiicii.

Aeyaeaii, ui canoinoaaiiy aaeaeaoa SL ? eaioii?eea i?eaiaeeoue aei
a?aeiinii? noaa?e?caoe?? aaiiaeeiai?ee, aiaeai?eea – aei cieaeaiiy
e?ioeaai-nenoie?/iiai ia’?io (ENI) EO, a i?ecia/aiiy eiia?iiaaii?
oa?ai?? aiaeai?eeii oa aaeaeaoii SL – aei cieaeaiiy ENI,
e?ioeaai-ae?anoie?/iiai ia’?io (EAeI) ? i?aeaeuaiiy o?aeoe?? aeeeaeo
(OA) EO.

Iieacaii iiaeeea?noue cieaeaiiy a?ia?aeoeaiino? ?AN i?ae aieeaii oa?ai??
?AIO oa eiia?iaoe?? ?AIO c aioaaii?noaie eaeueoe?y. Iaea?eueoiai aoaeoo
aaea?oueny aeiaeoeny i?e canoinoaaii? eiia?iiaaii? oa?ai?? aiaeai?eeii ?
aaeaeaoii SL, yea, e??i oiai, ia noi?iaiaeaeo?oueny ci?iaie
aeaeo?ie?oiiai aaeaino.

Aeai?, io?eiai? i?e aeeiiaii? ?iaioe, aeei?enoai? a iaaeaaia?/iiio
i?ioean? ia eaoaae?? aioo??oi?o oai?ia, EOE oa NI Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. ?ic?iaeaio aeeoa?aioe?eio noaio
e?eoaaiiy oai?eo ?ON, ui ia?aianee aino?ee ?I, ai?iaaaeaeaii a i?aeoeeo
?iaioe aei?iaeiuei? ee?i?/ii? e?ea?i? ?2 ICAe oa i?nueei? ee?i?/ii?
e?ea?i? ?27 i. Oa?eiaa, Aea?aa/?anueei? oeaio?aeueii? ee?i?/ii?
e?ea?i?, Ciei/?anueei? oeaio?aeueii? ?aeiiii? e?ea?i?, ?aeiiii?
iie?ee?i?ee ?9 i. Oa?eiaa, a ?acoeueoao? aeinyaiooi iie?auaiiy i?iaiico
caoai?thaaiiy, cieaeaiiy /anoioe oaeeo ee?i?/ii aaaeeeaeo iiae?e, ye
nia?oue, ?a?ioa?eo oa i?ia?anoaaiiy na?oeaai? iaaeinoaoiino?.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai iniaenoi i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a ii i?iaeai?, ui aea/aeanue, i?iaaaeaii
ee?i?ei-?ino?oiaioaeueia ianoaaeaiiy a oiio /ene? oeueo?acaoeiaa
ianoaaeaiiy oa ia?iaea aeaieo aeaeo?iea?ae?ia?ao?? c aeei?enoaiiyi
i?ea?iaeueii? iaoiaeeee. ?ic?iaeaia noaia aeeoa?aioe?eiaaiiai
i?ecia/aiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo aiaeai?eea
iaeaaoii ? eaioii?eeii oa aioaaii?noa eaeueoe?th aaeaeaoa SL a
caeaaeiino? a?ae ia?aa?ao i?ney?ioa?eoiiai ia??iaeo. Aaoi?ii i?iaaaeaia
noaoenoe/ia ia?iaea ? aiae?c io?eiaieo ?acoeueoao?a c aeei?enoaiiyi
no/anieo iaoaiaoe/ieo iaoiae?a oa eiii’thoa?ii? oaoi?ee. Caeiaoaa/ai
naiino?eii iaienai? an? ?icae?ee ?iaioe, noi?ioeueiaaii aeniiaee oa
i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny oa iaaiai?thaaeeny ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
iieiaeeo a/aieo (Oa?e?a, 1996, 1997), can?aeaiiyo Oa?e?anueeiai
iaoeiai-iaaee/iiai oiaa?enoaa (Oa?e?a, 1998), XIV c’?cae? oa?aiaao?a
Oe?a?ie (Ee?a, 1998), iaoeiai-i?aeoe/i?e eiioa?aioe?? “Iia? ai?eciioe
ee?i?ee aioo??oi?o caoai?thaaiue” (Oa?e?a, 1998).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 6 ?ia?o (4 noaoo? o
iaoeiaeo aeo?iaeao oa 2 noaoo? a ca??ieeao iaoeiaeo i?aoeue).

No?oeoo?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia 153
noi??ieao ae?oeiaaiiai oaenoo, ?ethno?iaai? 9 iaethieaie oa 9 oaaeeoeyie
(ui neeaaea? 15 noi??iie) ? neeaaeathoueny c? anooio, iaeyaeo
e?oa?aoo?e, 5 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e. Nienie aeei?enoaii? e?oa?aoo?e i?noeoue 191
aeaea?aei (ui neeaaea? 25 noi??iie), c yeeo 37 a?o/eciyieo oa 154
ca?oa?aeieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

A ianoaaeaiiy aoei aeeth/aii 120 oai?eo ?ON, ye? ia?aianee aino?ee ?I
oa ciaoiaeeeeny i?ae iaaeyaeii a ?aeiiieo iie?ee?i?eao ? 27 ? 28
i.Oa?eiaa a ia??iae c 1996 ii 1998 ?iee.

Ae?aaiic ?I aenoaaeyany c o?aooaaiiyi e?eoa???a AIIC. Ia?aa?a aino?iai
ia??iaeo ?I (oneeaaeiaiee, iaoneeaaeiaiee) ioe?ithaaee ca?aeii
?aeiiaiaeaoe?e E.Braunwald, 1993.

Oai?eo ianoaaeoaaee /a?ac 1, 3, 6 oa 12 i?nyoe?a a?ae ii/aoeo ?I.
Ianoaaeaiiy aeeth/aei ioe?ieo ee?i?/ieo, ?ino?oiaioaeueieo oa
eaai?aoi?ieo ia?aiao??a.

Ae?aaiic noaiiea?ae??, ?? oa?aeoa? oa ooieoe?iiaeueiee eean (OE)
anoaiiaethaaee ca?aeii c iaoiaee/ieie ?aeiiaiaeaoe?yie AIEOe AII N?N?
(1983), ?ic?iaeaieo ia i?aenoaa? e?eoa???a AIIC 1979 ?. Aeey ioe?iee
nooiaiy NI aeei?enoiaoaaee eeaneo?eaoe?th o?ii?/ii? na?oeaai?
iaaeinoaoiino? Iueth-Ei?enueei? anioe?aoe?? ea?ae?ieia?a (NYHA, 1973).

?a?no?aoe?th AEA niieith i?iaiaeeee a 12 noaiaea?oieo a?aeaaaeaiiyo c
aeei?enoaiiyi i?e iaiao?aeiino? aeiaeaoeiaeo a?aeaaaeaiue. I?e oeueiio
ioe?ithaaee noai naaiaioo ST AEA (ia ?cie?i??/aeaaaoe?y) oa coaoey O
(iiceoeaiee/iaaaoeaiee). I?iaiaeeee aiae?c e?ioeaai? /anoeie
oeoii/eiaiai eiiieaeno AEA c o?aooaaiiyi ?aeiiaiaeaoe?e Kusniec J. et
al., 1997. O oai?eo c ia?aaei?i ?I aeae?eyee 4 oeie AEA: oei A (ST ia
?cie?i??, O iaaaoeaiee); oei A (aeaaaoe?y ST, O iaaaoeaiee); oei N (ST
ia ?cie?i??, O iiceoeaiee); oei D (aeaaaoe?y ST, O iiceoeaiee).

Aeine?aeaeaiiy nei?ioeeai? caeaoiino? i?iea?aea ? ia?aiao??a
aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii aoiea?ae?ia?ao?? ca aeiiiiiaith
aia?aoa “Aloka SSD-280” (ssiii?y) oa OE-628 (Oe?a?ia) /a?ac 1 oa 12
i?nyoe?a i?ney ia?aianaiiai aino?iai ?I. I?e oeueiio ?ic?aoiaoaaee oae?
iieacieee, ye ENI, EAeI ? OA EO.

Aecia/aiiy ai?noo eae?y oa iao??y a ieaci? e?ia? i?iaiaeeee iaoiaeii
iieoi’yii? oioiiao???.

E?euee?nia aecia/aiiy ai?noo aia?ioaiceia II oa aeoeai?noue ?ai?ia a
ieaci? e?ia? i?iaiaeeee ?aae?i?ioiieia?/iei iaoiaeii ca aeiiiiiaith
iaai??a o??ie DRG (NOA) aeey aia?ioaiceia II oa o??ie SB-REN2 (O?aioe?y)
aeey ?ai?ia. An? ?aaeoeae aeei?enoiaoaaeenue ca?aeii ?ino?oeoe?? aeey
i?iaaaeaiiy aiae?c?a.

Noaoenoe/ia ia?iaea aeaieo i?iaiaeeeanue ca?aeii i?aaee ia?iaee
iaaee/ii-a?ieia?/ii? ?ioi?iaoe?? ca aeiiiiiaith noaoenoe/ii? i?ia?aie
STATISTICA FOR WINDOWS (StatSoft, NOA). An? io?eiai? aeai? iiaeaii o
aeaeyae? na?aaeiueiai a?eoiaoe/iiai (I) eiai noaiaea?oia aeaa?aoe?y
(SD).

?acoeueoaoe aeanieo aeine?aeaeaiue

Na?aae ianoaaeaieo 120 oai?eo aoei 90 /ieia?e?a oa 30 ae?iie
(ni?aa?aeiioaiiy /ieia?ee/ae?iee neeaei 3:1), na?aaei?e a?e 55,45,2
?iee.

Aiae?c aiaiianoe/ieo aeaieo iieacaa, ui o 42 (35%) iaoe??io?a ?I aoa
ia?oei ee?i?/iei i?iyaii ?ON. Noaiiea?ae?th ??cieo ooieoe?iiaeueieo
eean?a iaee 52 (43,3%) iaoe??ioe, o 26 oai?eo aei iiyae ?I aeyaeyany
ia??iae aeanoaa?e?caoe?? noaiiea?ae?? (ca?eueoaiiy /anoioe aai ci?ia
oa?aeoa?o aieueiaeo i?enooi?a, i?aeaeuaiiy i?eeiio ? oiea?aioiino? aei
i?o?iae?oea?eio), i?e/iio o 13 (10,8%) – aia?oa aeyaeaii?. ?I a
aiaiiac? a?aei?/aany o 13 (10,8%) c 120 iaoe??io?a. A?oa??aeueia
a?ia?oaic?y aeyaeyeanue o 67 (55,8%) oai?eo, oeoe?iaee ae?aaao – o 11
(9,2%) iaoe??io?a: o 10 – II oeio ? o 1 – I oeio. Caoai?thaaiiy
ia?eoa??eieo noaeei iaee 6 (5%) iaoe??io?a. I?aeaeuaia iana o?ea
a?aei?/aeanue o 21 (17,5%) oai?eo, 52 (43,3%) iaoe??io?a iaeeee.

Ia?aaeith eieae?caoe?th ?I (aeaaaoe?y naaiaioa ST oa/aai iayai?noue
coaoey Q o a?aea?aeaiiyo I, II, avL, v1-v4) aeyaeee o 72 (60%),
caaeiuei-ae?ao?aaiaeueiee (aeaaaoe?y naaiaioa ST oa/aai iayai?noue
coaoey Q o a?aea?aeaiiyo II, III, avF) – o 42 (35%), ia?aaeiuei-caaeith
(aeaaaoe?y naaiaioa ST oa/aai iayai?noue coaoey Q o a?aea?aeaiiyo II,
III, avF, v3-v5) – o 6 (5%) oai?eo. Ii aeeaei? o?aaeaiiy na?oeaaiai
i’yca o 84 (70%) ?I aoa o?ainio?aeueiei, o 36 (30%) – aaeeeiaiaieuaaei.

Oneeaaeiaiee ia?aa?a aino?iai ?I (?aoeeaeea aieth aai ?I, iaa?ye
eaaaiue, ea?ae?iaaiiee oie, ?inoeueo) a?aei?/aany o 62 (51,7%), ia
oneeaaeiaiee – o 58 (48,3%) oai?eo.

Ia 30-oo aeiao ?I noaiiea?ae?y a?aei?/aeanue o 19 (15,8%) iaoe??io?a; NI
I eeano – o 86 (71,1%) oai?eo; II eeano – o 25 (20,8%); III eeano – o 6
(5%); IV eeano – o 3 (2,5%) oai?eo.

I?e aiae?c? aeaieo AEA ci?ie oeio A ?a?no?oaaeeny o 29 (40,3%), oeio A –
o 13 (18,1%), oeio N – o 10 (13,9%), oeio D – o 20 (27,7%) iaoe??io?a.
Aeaii??ia aoiea?ae?ia?ao?y aeicaieeea aeyaeoe ciie an?ia?a?? i?iea?aea o
112 (93,3%) iaoe??io?a. Ioe?iea noaio aaiiaeeiai?ee iieacaea, ui
na?aaei?e EAeI EO o ianoaaeaieo oai?eo neeaa 95,926,3 ie, ENI EO –
46,616,3 ie ? OA EO – 52,615,7%. Aeai? aeaii??ii? aoiea?ae?ia?ao??
i?aeoaa?aeeee oi?ioaaiiy aino?i? i?ney?ioa?eoii? aiaa?ecie EO o 13
(10,8%) oai?eo.

An? oai?? a caeaaeiino? a?ae oeio oa?ai??, yea i?iaiaeeeany ia i?ioyc?
ianooiiiai i?ney ia?aianaiiai ?I ?ieo aeiaaeeiaei /eiii aoee ?icae?eai?
ia 4 a?oie, a eiaeio c yeeo aa?eoee ii 30 iaoe??io?a. Oai?? a a?oi? 1
iaea?aeoaaee eaioii?ee a aeic? 12,5 ia ia aeiao, a a?oi? 2 – aaeaeao SL
a aeic? 40 ia ia aeiao, a a?oi? 3 – aiaeai?ee a aeic? 10 ia ia aeiao, a
a?oi? 4 – eiia?iaoe?th aiaeai?eea a aeic? 10 ia ia aeiao ? aaeaeaoa SL a
aeic? 40 ia ia aeiao. A?oie aoee ii??aiyi? ii iniiaiei
ee?i?ei-aeaiia?ao?/iei iieacieeai.

Ia 30-oo aeiao ?I a a?oi? 1 i?ney?ioa?eoia noaiiea?ae?y niinoa??aaeanue
o 4 (13,3%) iaoe??io?a, NI > II eeano — o 8 (26,3%) iaoe??io?a. A a?oi?
2 i?ney?ioa?eoia noaiiea?ae?y aoea aeyaeaia o 3 (10%) iaoe??io?a, NI >
II eeano – o 7 (23,3%). A a?oi? 3 i?ney?ioa?eoia noaiiea?ae?y
a?aei?/aeanue o 6 (20%) iaoe??io?a, NI > II eeano – o 10 (33,3%). A
a?oi? 4 i?ney?ioa?eoia noaiiea?ae?y niinoa??aaeanue o 6 (20%)
iaoe??io?a, NI > II eeano – o 9 (30%) iaoe??io?a (a?aei?ie i?ae a?oiaie
iaa??ia?aei?).

*a?ac 3 i?nyoe? a?ae ii/aoeo ?I /anoioa i?ecia/aiiy noiooiuei? oa?ai??
(i?o?aoe, ae?o?aoeee, aaoa-aae?aiiaeieaoi?e oa ?o ii?aeiaiiy) a a?oi? 1
neeaea 53,3%; a a?oi? 2 – 66,7%; a a?oi? 3 – 43,3% ? a a?oi? 4 – 26,7%
(p<0.05 a ii??aiyii? c a?oiith 1, p<0.01 a ii??aiyii? c a?oiith 2). Aiae?c ee?i?/ii? aoaeoeaiino? oa?ai??, ui i?iaiaeeeanue a ??cieo a?oiao /a?ac 12 i?nyoe?a niinoa?aaeaiiy, i?aaenoaaeaii a oaaeeoe? 1. sse aeieeaa? c i?aaenoaaeaieo ?acoeueoao?a, o?eaaea (ia i?ioyc? ?ieo) oa?ai?y ?AIO oa ?AIO a ii?aeiaii? c aioaaii?noaie eaeueoe?y, ia a?aei?io a?ae oa?ai?? o?eueee aioaaii?noaie eaeueoe?y, o iaoe??io?a, ui ia?aianee ?I, i?ecaiaeeea aei cieaeaiiy /anoioe ?icaeoeo noaiiea?ae??. E?euee?noue iaoe??io?a c NI ca?eueooaaeanue ia i?ioyc? ?ieo na?aae oeo, ye? e?eoaaeenue o?eueee aioaaii?noaie eaeueoe?y ia a?aei?io a?ae a?oie oai?eo, ui io?eioaaee ?AIO (oi/a i?e e?eoaaii? eaioii?eeii oaiaeaioe?y aei ca?eueoaiiy e?eueeino? oaeeo iaoe??io?a ? a?aei?/aeanue) ? eiia?iiaaiith oa?ai??th. E??i oiai, a oeeo a?oiao a?aei?/aeanue a??ia?aeii iaioa e?euee?noue iaoe??io?a c i?ia?anoth/ith NI. Aeiaeaoeiaa oa?ai?y iio?aaoaaeanue a??ia?aeii iaio?e e?eueeino? iaoe??io?a, ye? io?eioaaee ?AIO oa eiia?iiaaio oa?ai?th, ia a?aei?io a?ae a?oie iaoe??io?a, ye? e?eoaaeenue o?eueee aioaaii?noaie eaeueoe?y. Ia?aoo?, oa?ai?y aiaeai?eeii ? ii?aeiaiiyi aiaeai?eea c aaeaeaoii SL i?eaiaeeea aei a??ia?aeiiai cieaeaiiy noia?ii? e?eueeino? oaeeo ee?i?/ii aaaeeeaeo iiae?e, ye nia?oue, ?a?ioa?eo ? i?ia?anoaaiiy NI a ii??aiyii? c oa?ai??th o?eueee aaeaeaoii SL aai eaioii?eeii. Oaaeeoey 1. Ee?i?/ia aoaeoeai?noue oa?ai?? /a?ac 12 i?nyoe?a e?eoaaiiy. Iieacieee (n, %)A?oia 1 n=30/28A?oia 2 n=30/27A?oia 3 N=30/29A?oia 4 n=30/29I?ney?ioa?eoa noaiiea?ae?y 11 (36,7) * 13 (43,3) † 11 (36,7) 9 (30)NI > II eeano10 (33,3)16 (53,3) *9 (30)8 (26,7) ‡Noiooiy oa?ai?y8
(28,5) ?24 (88,9)8 (27,5) ?4 (13,8) ?Oneeaaeiaiee ia?aa?a caoai?thaaiiy

8 (26,7) ‡

16 (53,3)

6 (20) §

2 (6,7) §¶I?ei?oee:

1. A /enaeueieeo iiaeaii caaaeueio e?euee?noue oai?eo a a?oi?, a o
ciaiaiieeo – e?euee?noue oai?eo, ye? cae?i/eee aeine?aeaeaiiy.

2. * — p<0.05 a ii??aiyii? c aeaieie aei e?eoaaiiy; † - p<0.01 a ii??aiyii? c aeaieie aei e?eoaaiiy; ‡ - p<0.05 a ii??aiyii? c aeaieie a a?oi? 2; § - p<0.01 a ii??aiyii? c aeaieie a a?oi? 2; ? - p<0.001 a ii??aiyii? c aeaieie a a?oi? 2; ¶ - p<0.05 a ii??aiyii? c aeaieie a a?oi? 1. Aieea oa?ai??, ui i?iaiaeeeanue ia i?ioeane ?aiiaeaethaaiiy EO ?, oei naiei, ia eiai nei?ioeeao caeaoi?noue (yeo ioe?ithaaee ca aeaieie aoiea?ae?ia?ao??) i?aaenoaaeaii a oaaeeoe? 2. Aiae?c ?acoeueoao?a, ye? aoei io?eiaii, na?ae/eoue i?i oa, ui oa?ai?y ?AIO 1-ai iieie?iiy (eaioii?ee) ia?aoeiaeaeo? ?icaeoeo aeeeaoaoe?? EO, cieaeaiith eiai nei?ioeeai? caeaoiino? ?, oei naiei, ?icaeoeo ? i?ia?anoaaiith NI. Aeei?enoaiiy a e?eoaaii? a i?ney?ioa?eoiiio ia??iae? ?AIO 2-ai iieie?iiy ia o?eueee ia?aoeiaeaeo? ?icaeoeo NI, aea ? i?eaiaeeoue aei ciaioaiiy aeeeaoaoe?? EO, ui, iaeiae, ia noi?iaiaeaeo?oueny i?aeaeuaiiyi eiai nei?ioeeai? caeaoiino?. Ia a?aei?/aii iie?auaiiy aaiiaeeiai?/ieo iieaciee?a a a?oi? oai?eo, ye? e?eoaaeenue o?eueee c aeei?enoaiiyi aaeaeaoa SL. I?ecia/aiiy aiaeai?eea a ii?aeiaii? c aaeaeaoii SL i?eaiaeeei aei ciaioaiiy aeeeaoaoe?? EO, i?i ui na?ae/eoue ciaioaiiy ENI ? EAeI, yea noi?iaiaeaeoaaeinue iie?auaiiyi nei?ioeeai? caeaoiino? i?iea?aea (i?aeaeuaiiyi OA). Oaaeeoey 2. Aeeiai?ea aaiiaeeiai?/ieo iieaciee?a a i?ioean? e?eoaaiiy ??cieie a?oiaie i?aia?ao?a (MSD). A?oie/ iieacieeeA?oia 1 n=30A?oia 2 N=30A?oia 3 n=30A?oia 4 n=30ENI (ie) Aei e?eoaaiiy I?ney e?eoaaiiy 47,212,8 48,914,3 46,414,2 49,813,9 47,113,8 43,112,8 48,012,9 41,913,3*EAeI (ie) Aei e?eoaaiiy I?ney e?eoaaiiy 97,625,4 98,624,9 98,024,3 106,125,2 96,923,1 93,221,1* 97,521,8 92,425,4*OA (%) Aei e?eoaaiiy I?ney e?eoaaiiy 51,015,1 50,614,1 50,313,7 47,513,3 51,114,1 54,313,8 50,814,5 55,214,1* I?ei?oee: * - p < 0.05 i?e ii??aiyii? ?acoeueoao?a i?ney e?eoaaiiy c a?oiith 2. C iaoith i?iaiicoaaiiy iiaeaeueoiai ia?aa?ao ?ON i?ney ia?aianaiiai ?I aoa i?iaaaeaiee aiae?c AEA (e?ioeaai? /anoeie oeoii/eiaiai eiiieaeno) /a?ac 1 i?nyoeue. Aoei i?iaiae?ciaaii aeai? 72 iaoe??io?a c ia?aaeiueith eieae?caoe??th ?I, yeeo ?icae?eeee ia a?oie a caeaaeiino? a?ae oei?a ci?i AEA (oaaeeoey 3). Oaaeeoey 3. Iieacieee aaiiaeeiai?ee oai?eo /a?ac 1 i?nyoeue i?ney ia?aianaiiai ?I o oai?eo a caeaaeiino? a?ae ci?i AEA (MSD). A?oie/ iieacieeeEAeI (ie)ENI (ie)OA (%)Oei A (n=29)90,421,141,412,357,214,4Oei B (n=13)104,628,4†54,712,8†47,311,1*Oei C (n=10)96,325,747,515,151,314,6Oei D (n=20)112,339,5‡58,213,9‡41,713,7‡I?ei?oee: * - p < 0.05, † - p<0.01, ‡ - p<0.001 a ii??aiyii? c aeaieie i?e oei? A. Aiae?c io?eiaieo ?acoeueoao?a iieaco?, ui ci?ie AEA oeio B ? D (iaeaeaa oeie oa?aeoa?ecothoueny aeaaaoe??th naaiaioa ST) anioe?ththoueny c a??oeie iieacieeaie aioo??oiueina?oeaai? aaiiaeeiai?ee, /ei oeie A ? N (iaeaeaa oeie oa?aeoa?ecothoueny ciaoiaeaeaiiyi naaiaioa ST ia ?cie?i??). Oea aeicaieeei ia’?aeiaoe aeai? a?oie ye ni?eyoeea? (AEA oeio A aai N) oa iani?eyoeea? (AEA oeio B aai D) a aaiiaeeiai?/iiio a?aeiioaii?. A?aeiia?aeii, a 1-oo a?oio aa?eoee 39 (54,2%) iaoe??ioe, a a 2 – 33 (45,8%) iaoe??ioe. Na?aaei? cia/aiiy EAeI i?e AEA oeiao B+D neeaee /a?ac 1 i?nyoeue i?ney ia?aianaiiai ?I 106,831,4 ie, ENI – 56,414,1 ie ? OA EO – 45,413,7 %. I?e iiaeaeueoiio ianoaaeaii? /a?ac 12 i?nyoe?a iieacieee aaiiaeeiai?ee a oe?e a?oi? oai?eo iia??oeeenue (?en. 1). A?aei?/aeanue iiaeaeueoa oaiaeaioe?y aei ca?eueoaiiy EAeI - 119,538,2 ie oa cieaeaiiy OA EO aei 40,913,1 % (a?aei?ie iaa??ia?aei?, p>0.20) i?e a??ia?aeiiio ca?eueoaii?
cia/aiue ENI aei 67,314,2 ie, (a?aei?ie a??ia?aei? ii??aiyii ?c
cia/aiiyie /a?ac 1 i?nyoeue, p<0.01). picscalex100010009000003bc1600000e003500000000001400000026060f001e00ffff ffff040014000000576f72640e004d6963726f736f667420576f7264050000000b020000 0000050000000c021504530613000000fb0200000000000000000000000000cc00000001 436f7572696572204e657700cc00040000002d010000040000000201010015000000fb02 cfff0000000000009001000000000440001254696d6573204e657720526f6d616e000000 040000002d01010005000000090200000000040000000201010007000000fc0201000000 00000000040000002d01020009000000fa02050000000000ffffff002200040000002d01 0300070000001b04a803c2066b03120007000000fc020000ffffff000000040000002d01 040009000000fa02000000000000000000002200040000002d010500030000001e000700 00001604a603c2066b031200040000000201010010000000fb02cfff000000000000bc02 0000000004400022417269616c000000040000002d0106000500000014026c0312001000 0000fb02cfff000000000000bc02000000cc04400022417269616c00cc00040000002d01 0700040000002e01010017000000320a6c031200080004000000000053061504d0e8f12e 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04000000000053061504c5cac3321e0021001c001700040000002e010000040000002d01 0c0004000000f0010d0005000000140257010000040000002d0101000400000002010100 040000002701ffff040000002d010200040000002d010300070000001b0482012b044001 9703040000002d010400040000002d010500030000001e0007000000160481012b044101 97030400000002010100040000002d010c00050000000902000000000500000014024201 970315000000fb02d3ff000000000000bc02000000cc0440001254696d6573204e657720 526f6d616e00cc00040000002d010d00040000002e01010011000000320a420197030400 04000000000053061504c5cac3311e0021001c001700040000002e010000040000002d01 0c0004000000f0010d0005000000140257010000040000002d0101000400000002010100 040000002701ffff040000002d010200040000002d010300070000001b048201d1044001 3d04040000002d010400040000002d010500030000001e000700000016048101d1044101 3d040400000002010100040000002d010c00050000000902000000000500000014024201 3d0415000000fb02d3ff000000000000bc02000000cc0440001254696d6573204e657720 526f6d616e00cc00040000002d010d00040000002e01010011000000320a42013d040400 04000000000053061504c5cac3321e0021001c001700040000002e010000040000002d01 0c0004000000f0010d0005000000140257010000040000002d0101000400000002010100 040000002701ffff040000002d01080009000000fa020000020000000000000222000400 00002d010d00070000001b04630000053a00d704040000002d010400040000002d010500 04000000f0010d00040000002d010200040000002d010300070000001b047e004c063100 1b05040000002d010400040000002d010500030000001e000700000016047d004c063100 1b050400000002010100040000002d010600050000000902000000000500000014023200 1b0510000000fb02cfff000000000000bc02000000cc04400022417269616c00cc000400 00002d010d00040000002e01010017000000320a32001b05080004000000000053061504 f7e5f0e5e72031201c001b001e001b0018000e001b000e00040000002e01000004000000 2d01060004000000f0010d00050000001402570100000500000014023200da0510000000 fb02cfff000000000000bc02000000cc04400022417269616c00cc00040000002d010d00 040000002e01010010000000320a3200da05030004000000000053061504ecb3f1002300 0e001b00040000002e010000040000002d01060004000000f0010d000500000014025701 00000400000002010100040000002701ffff1000000026060f001600ffffffff0000d304 00009700000003050000c70000000800000026060f000600ffffffff0000040000002d01 0300040000002d0102000400000007010400050000000102ffffff000500000009020000 000035000000420105000000280000000800000008000000010001000000000020000000 0f2d00000f2d0000020000000200000000000000ffffff00cc6666666633333333999999 99cccccccc666666663333333399999999cccccc905f04c0e80052c1d0467bc28d952bc0 040000002d010d00040000002d010d00090000001d062100f000280028009b00d7040400 00002d010d000500000009020100000005000000010201000000040000002d0102000400 0000f0010d00040000002d010500040000002d0104000400000007010100080000002606 0f000600ffffffff010009000000fa02000001000000000000002200040000002d010d00 040000002d010200070000001b04c40000059b00d704040000002d01050004000000f001 0d00040000002d0104000800000026060f000600ffffffff0100040000002d0102000400 00002d010300070000001b04df00680692001b05040000002d010400040000002d010500 030000001e00070000001604de00680692001b050400000002010100040000002d010600 0500000009020000000005000000140293001b0510000000fb02cfff000000000000bc02 000000cc04400022417269616c00cc00040000002d010d00040000002e01010019000000 320a93001b05090004000000000053061504f7e5f0e5e720313220001c001b001e001b00 18000e001b001b000e00040000002e010000040000002d01060004000000f0010d000500 00001402570100000500000014029300f50510000000fb02cfff000000000000bc020000 00cc04400022417269616c00cc00040000002d010d00040000002e01010010000000320a 9300f505030004000000000053061504ecb3f10023000e001b00040000002e0100000400 00002d01060004000000f0010d0005000000140257010000040000000201010004000000 2701ffff040000002d0100000300000000000000000000000000 I?e AEA oei?a A+N aeo?aei? cia/aiiy EAeI neeaee 89,119,3 ie, p<0.01 a ii??aiyii? c oeiaie B+D, ENI – 44,511,8 ie, p<0.001 a ii??aiyii? c oeiaie B+C, oa OA EAE – 54,311,2%, p<0.01 a ii??aiyii? c oeiaie A+N. *a?ac 12 i?nyoe?a o aeaii? a?oie oai?eo iieacieee, ui aea/aeenue, neeaee: EAeI - 84,120,6 ie, p<0.001 a ii??aiyii? c oeiaie B+D i?ney e?eoaaiiy; ENI – 41,813,0 ie, p<0.001 a ii??aiyii? c oeiaie B+C i?ney e?eoaaiiy; OA EO – 59,215,2%, p<0.001 a ii??aiyii? c oeiaie A+N i?ney e?eoaaiiy. Ana?aaeei? a?oie aoee aeyaeai? oaiaeaioe?? aei ciaioaiiy EAeI ? ENI, a oaeiae i?aeaeuaiiy OA EO ia oii? e?eoaaiiy, ye? ia aeinyaee a??ia?aeieo a?aei?i. A a?oi? 1 oa?ai?y eaioii?eeii i?eaaea aei a??ia?aeiiai ciaioaiiy /enea iaoe??io?a c “iani?eyoeeaeie” oeiaie AEA c 47,1% (8 iaoe??io?a) aei 11,8% (2 iaoe??ioa), p<0.05. A a?oi? 2 i?e e?eoaaii? aioaaii?noaie eaeueoe?y oea ciaioaiiy ia aoei a??ia?aeiei – c 36,8% (7 iaoe??io?a) aei 31,5% (6 iaoe??io?a), p>0.2. A a?oi? 3 i?e e?eoaaii? aiaeai?eeii
e?euee?noue “iani?eyoeeaeo” AEA a??ia?aeii ciaioeeanue c 50% (9
iaoe??io?a) aei 11,1% (2 iaoe??ioe), p<0.01. I?e eiia?iiaaiiio canoinoaaii? ?AIO oa aioaaii?no?a eaeueoe?y a 4 a?oi? oea cieaeaiiy aoei iaea?eueo cia/iei – c 50% (9 iaoe??io?a) aei 5,6% (1 iaoe??io), a?aei?ie a??ia?aei?, p<0.01. I?e ii/aoeia?e a?aenooiino? a?aei?i i?ae a?oiaie a e?eueeino? oai?eo c “iani?eyoeeaeie” oeiaie AEA, i?ney e?eoaaiiy a?aei?ie i?ae a?oiaie iaoe??io?a, ye? e?eoaaeeny aioaaii?noaie eaeueoe?y oa eiia?iaoe??th ?AIO c aioaaii?noaie eaeueoe?y iaaoaathoue noaoenoe/ii a??ia?aeieo a?aei?i. O an?o ianoaaeaieo a?oiao iaoe??io?a ia 30 aeiao ?I a?aei?/aeanue a?ia?aeoeai?noue ?AN. Oae, a a?oi? 1 aeoeai?noue ?ai?ia ieacie neeaea 4,91,4 ia/ie/aiae (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth - 3,10,8 ia/ie/aiae), eiioeaio?aoe?y aia?ioaiceia II - 5,71,7 ia/ie (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth - 3,81,2 ia/ie); a a?oi? 2 aeoeai?noue ?ai?ia - 5,01,6 ia/ie/aiae (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth), eiioeaio?aoe?y aia?ioaiceia II - 5,91,5 ia/ie (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth); a a?oi? 3 aeoeai?noue ?ai?ia - 5,11,7 ia/ie/aiae (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth), ai?no aia?ioaiceia II - 6,01,8 ia/ie (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth); a a?oi? 4 aeoeai?noue ?ai?ia - 4,81,5 ia/ie/aiae (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth), eiioeaio?aoe?y aia?ioaiceia II - 5,81,7 ia/ie (p<0.001 a ii??aiyii? c aeaieie a?oie eiio?ieth). O iaoe??io?a, ye? io?eioaaee eaioii?ee (a?oia 1) ? aiaeai?ee (a?oia 3) /a?ac 3 i?nyoe? e?eoaaiiy a?aei?/aeinue cia/ia i?aeaeuaiiy aeoeaiino? ?ai?ia ieacie a ii??aiyii? c aeaieie, ye? io?eiaii i?e ianoaaeaii? /a?ac 1 i?nyoeue i?ney ?I – 6,21,8 ia/ie/aiae (p<0.01 a ii??aiyii? c aeaieie aei e?eoaaiiy) oa 6,31,9 ia/ie/aiae (p<0.02 a ii??aiyii? c aeaieie aei e?eoaaiiy), a?aeiia?aeii. A a?oi? iaoe??io?a, ye? io?eioaaee aaeaeao SL, ye ? a a?oiao oai?eo, ui e?eoaaeenue ?AIO, a?aei?/aeinue a??ia?aeia i?aeaeuaiiy ai?noo ?ai?io - 5,91,7 ia/ie/aiae (p<0.02 a ii??aiyii? c aeaieie aei ii/aoeo e?eoaaiiy), iacaaaeath/e ia ??ci? iaoai?cie ae?? oeeo i?aia?ao?a. O?eueee o iaoe??io?a 4 a?oie (eiia?iiaaia oa?ai?y aiaeai?eeii ? aaeaeaoii SL) a i?ioean? e?eoaaiiy a?aei?/aii a??ia?aeia cieaeaiiy aeoeaiino? ?ai?ia aei 3,60,9 ia/ie/aiae, i?e/iio ia o?eueee a ii??aiyii? c aeaieie aei e?eoaaiiy (p<0.001), aea ? a ii??aiyii? c a?oiith eiio?ieth (p<0.05). Ai?no aia?ioaiceia II aeinoia??ii ciaiooaaany a i?ioean? e?eoaaiiy i?ae aieeaii ?AIO (a?oia 1 ? a?oia 3), a??ia?aeii, ca ?aooiie i?eai?/aiiy eiai ooai?aiiy ii AIO-caeaaeiiio oeyoo ? neeaa 4,21,3 ia/ie (p<0.001 a ii??aiyii? c aeaieie aei e?eoaaiiy) oa 4,11,4 ia/ie (p<0.001 a ii??aiyii? c aeaieie aei e?eoaaiiy), a?aeiia?aeii. A a?oi? 2 ai?no aia?ioaiceia II caeeoaany aenieei ? neeaa 6,01,8 ia/ie. A a?oi? 4 a?aei?/aii iaea?eueo cia/ia cieaeaiiy ??aiy aia?ioaiceia II, yeee neeaa 3,71,1 ia/ie (p<0.001 a ii??aiyii? c aeaieie aei e?eoaaiiy), ui iiaea aooe iane?aeeii ye i?eai?/aiiy AIO, oae ? cieaeaiiy aeoeaiino? ?ai?ia ieacie o oeeo iaoe??io?a. I?e ii??aiyi?e ii/aoeia?e aeoeaaoe?? ?AN o oai?eo i?ney aino?iai ?I ciaioaiiy ?? a?ia?aeoeaiino? aoei oa?aeoa?ii aeey iaoe??io?a 1-?, 3-? ? 4-? a?oi, i?e/iio iaea?eueoee aoaeo aoa aeinyaiooee o oai?eo 4-? a?oie. ?ioei aniaeoii, yeee aecia/a? aacia/i?noue o?eaaei? oa?ai?? oai?eo i?ney ?I ? aieea i?aia?ao?a ia aeaeo?ie?oiee iai?i. A??ia?aei? ci?ie ai?noo aeaeo?ie?o?a a ieaci? a?aei?/aeenue a a?oi? 2 ca ?aooiie cieaeaiiy ??aiy iao??y a ieaci? c 14515 iiieue/e aei 13519 iiieue/e (p<0.05) oa a a?oiao 1 ? 3 – ca ?aooiie i?aeaeuaiiy ??aiy eae?y ieacie: c 4,00,8 iiieue/e aei 4,61,2 iiieue/e (p<0.05) ? c 4,10,9 iiieue/e aei 4,61,0 iiieue/e (p<0.05), a?aeiia?aeii. Iaeiae, ci?ie aeaieo iieaciee?a i?e oeueiio ia aeeoee ca ?aiae ii?iaeueieo cia/aiue. Eiia?iiaaia oa?ai?y aiaeai?eeii oa aaeaeaoii SL ia aeeacoaaea cia/iiai aieeao ia aeaeo?ie?oiee aaeain. C iaoith ?iaeea?aeoae?caoe?? e?eoaaiiy oai?eo ?ON, ui ia?aianee aino?ee ?I oa iiooeo e?eoa???a a?aeai?o aeey oa?ai??, ye? iiaeia aoei a aeei?enoiaoaaoe a oe?ie?e ee?i?/i?e i?aeoeoe?, aoei i?iaaaeaii aiae?c aoaeoeaiino? oa?ai?? a caeaaeiino? a?ae ?eceeo iani?eyoeeaiai ia?aa?ao caoai?thaaiiy, ui aaco?oueny ia ee?i?ei-?ino?oiaioaeueieo iieacieeao. C o?aooaaiiyi iacaaeia?eueiiai ia?aa?ao i?ney?ioa?eoiiai ia??iaeo o oai?eo, ye? io?eioaaee iiiioa?ai?th aaeaeaoii SL, oey a?oia iaoe??io?a aei iiaeaeueoiai aiae?co ia aeeth/aeanue. Aeey ioe?iee aieeao oa?ai??, ui i?iaiaeeeanue, ia i?iaiic caoai?thaaiiy ianoaaeaieo iaoe??io?a ?icae?eeee ia 2 a?oie. 1-oo a?oio neeaee oai??, ye? i?eeiaee iaeei c ?AIO – eaioii?ee aai aiaeai?ee (n=60). Oi/ i?ae oeeie a?oiaie ?niothoue iaai? a?aei?iiino? a ee?i?/iiio ia?aa?ao oa ci?iao ia?aiao??a oeaio?aeueii? aaiiaeeiai?ee, aiie a a?eueoino? aeiaaee?a iineee oa?aeoa? oaiaeaioe?e, ui e aeicaieeei ia’?aeiaoe ?o a iaeio a?oio. 2-ao a?oio neeaee oai??, ye? o?eaaeee /an i?eeiaee eiia?iaoe?th aiaeai?eea oa aaeaeaoa SL (n=30). Aeey aiae?co ee?i?/iiai ia?aa?ao caoai?thaaiiy aoei aeei?enoaii 2 /ania? ia??iaee – 3 oa 12 i?nyoe?a a?ae ii/aoeo i?iaaaeaiiy oa?ai??. Ia?aiao?e, ui ioe?ithaaeenue, aeeth/aee iayai?noue ? /anoioo noaiiea?ae??, cano?eii? na?oeaai? iaaeinoaoiino? (NI>2 nooiaith ii eeaneo?eaoe??
NYHA), oneeaaeiaiee ia?aa?a i?ney?ioa?eoiiai ia??iaeo oa /anoioa
i?ecia/aiiy aeiaeaoeiaeo a?oi oa?iaeieia?/ieo i?aia?ao?a (i?o?ao?a,
aaoa-aae?aiiaeieaoi??a ? ae?o?aoee?a).

I?e ii/aoeo i?ecia/aiiy iaeiiai c aa??aio?a o?eaaei? oa?ai?? (/a?ac 1
i?nyoeue a?ae ?icaeoeo aino?iai ?I) a?oie ia a?ae??ciyeenue ii iniiaiei
ee?i?ei-aiaiianoe/iei oa?aeoa?enoeeai.

Ioe?iea ee?i?/ieo aeaieo o ianoaaeaieo iaoe??io?a /a?ac 3 i?nyoe? a?ae
?icaeoeo aino?iai ?I iieacaea, ui noaiiea?ae?y a 1-e a?oi? oai?eo, ye?
e?eoaaeenue ?AIO, niinoa??aaeanue o 14 (23,3%) iaoe??io?a, iciaee
cano?eii? na?oeaai? iaaeinoaoiino? – o 18 (30%) iaoe??io?a. *anoioa
i?ecia/aiiy aeiaeaoeiaiai e?eoaaiiy a iniiaiiio c-ca ?icaeoeo
noaiiea?ae??, NI aai ii?ooaiue na?oeaaiai ?eoio /a?ac 3 i?nyoe?
niinoa?aaeaiiy a 1-e a?oi? neeaea 48,3% (29 oai?eo).

Oneeaaeiaiee ia?aa?a i?ney?ioa?eoiiai ia??iaeo aeeth/aa iayai?noue oaeeo
ee?i?/ii aaaeeeaeo iiae?e, ye i?ia?anoaaiiy NI, ?a?ioa?eo ? nia?oue, oe?
oneeaaeiaiiy aoee ia’?aeiai? ana?aaeei? a?oi. A ?acoeueoao?, a a?oi? 1
oaeee ia?aa?a caoai?thaaiiy aoei a?aei?/aii a 8 oai?eo 1-? a?oie (13,3%
aeiaaee?a).

A 2-e a?oi? iaoe??io?a, ye? io?eioaaee ii?aeiaio oa?ai?th aiaeai?eeii ?
aaeaeaoii SL, e?euee?noue oai?eo c iayai?noth noaiiea?ae?? oa iciae NI
i?aeoe/ii ia a?ae??ciyeanue, oa neeaea 23,3% (7 iaoe??io?a) ? 9 (30%)
oai?eo, a?aeiia?aeii.

A a?oi? 2 /a?ac 3 i?nyoe? a?ae ii/aoeo i?iaaaeaiiy oa?ai?? a?aei?/aii
oaiaeaioe?th aei cieaeaiiy /anoioe oneeaaeiaiue oa a??ia?aeii iaioa
/anoioa i?ecia/aiiy aeiaeaoeiai? oa?ai??, yeo iio?aaoaaee 8 (26,7%)
oai?eo, p<0.05 ii a?aeiioaiith aei a?oie iiiioa?ai?? ?AIO. *a?ac 12 i?nyoe?a niinoa?aaeaiiy a a?oi? iaoe??io?a, ye? e?eoaaeeny eiia?iiaaiith oa?ai??th ?AIO oa aioaaii?noii eaeueoe?y a?aei?/aeany oaiaeaioe?y aei cieaeaiiy /anoioe noaiiea?ae?? – 9 iaoe??io?a (30%) i?ioe 22 iaoe??io?a (36,6%) a 1-e a?oi?; NI – o 8 (26,7%) i?ioe 19 (31,7%) oa iaiao?aeiino? i?ecia/aiiy aeiaeaoeiaeo a?oi oa?iaeieia?/ieo i?aia?ao?a – o 4 (13,8%) i?ioe 16 (28,1%) oai?eo, ii a?oiai a?aeiia?aeii. A oie aea /an a 1-e a?oi? /anoioa oneeaaeiaiiai ia?aa?ao caoai?thaaiiy aoea a??ia?aeii aeuith oa neeaea 23,3% (14 iaoe??io?a) i?ioe 6,7% (2 iaoe??ioe) a a?oi? 2, p<0.05. ?acoeueoaoe, ye? i?eaaaeaii, na?ae/aoue i?i oa, ui a?aei?/ai? /a?ac 3 i?nyoe? oaiaeaioe?? aei ciaioaiiy /anoioe oneeaaeiaiue a a?oi? oai?eo, ye? e?eoaaeeny eiia?iaoe??th aiaeai?eea ? aaeaeaoa SL /a?ac 12 i?nyoe?a niinoa?aaeaiiy aeinyaathoue a??ia?aeieo a?aei?i. A ?acoeueoao? aiae?co aeeiai?ee aaiiaeeiai?/ieo iieaciee?a a?aei?/aii, ui a iaio a?oiao oai?eo i?ecia/aiiy ?AIO a aeaeyae? iiiioa?ai?? oa ii?aeiaia i?ecia/aiiy ?AIO aiaeai?eea ? aioaaii?noa eaeueoe?y aaeaeaoa SL i?eaiaeeei aei iie?auaiiy ia?aiao??a oeaio?aeueii? aaiiaeeiai?ee ? ciaioaiiy aeeeaoaoe?? EO. I?i oea na?ae/eee ciaioaiiy EAeI ? ENI ca aeaieie aoiea?ae?ia?ao??, ui noi?iaiaeaeoaaeinue iie?auaiiyi nei?ioeeai? caeaoiino? i?iea?aea, a?eueo cia/iei a 2-e a?oi? ianoaaeaieo. Oae, a 1-e a?oi? ENI /a?ac 12 i?nyoe?a e?eoaaiiy cieceany ia 2,90,8 ie, a a a?oi? 2 – ia 5,91,9 ie (p<0.001); ENI – ia 2,80,7 oa 5,71,8 (p<0.001) oa o?aeoe?y aeeeaeo – ia 2,10,7% ? 4,91,6% (p<0.001), ii a?oiai a?aeiia?aeii. Iacaaaeath/e ia oa, ui ii?aeiaia oa?ai?y ?AIO oa aioaaii?noii eaeueoe?y a 2-e a?oi? oai?eo aoea iaea?eueo aoaeoeaiith, i?ecia/aoe ?? an?i iaoe??ioai iaia iaiao?aeiino?. C iaoith no?aoeo?eaoe?? oai?eo ii nooiaith ?o ?eceeo iaie aoea aeei?enoaia oeaea ioe?iee i?iaiico ?I, cai?iiiiiaaia A.E.R. Arnold ? M. Simoons (1997). A?aeiia?aeii, a 1-e a?oi? aoei aeae?eaii 37 oai?eo c iani?eyoeeaei i?iaiicii, na?aaei?e i?iaiinoe/iee ?iaeaen ca oeaeith A.E.R. Arnold ? M. Simoons neeaa 21%. A 2-e a?oi? aoei 19 oaeeo iaoe??io?a, na?aaei?e i?iaiinoe/iee ?iaeaen neeaa 22%. A a?oi? iaoe??io?a, ye? io?eioaaee ?AIO, /a?ac 12 i?nyoe?a e?eoaaiiy aeaiee i?iaiinoe/iee ?iaeaen cieceany aei 17% (a?aeiinia cieaeaiiy iieacieea i?e oeueiio neeaei 19%). O iaoe??io?a, ye? e?eoaaeeny eiia?iaoe??th ?AIO oa aioaaii?noa eaeueoe?th, na?aaei?e i?iaiinoe/iee ?iaeaen /a?ac 12 i?nyoe?a neeaa 11% (a?aeiinia cieaeaiiy iieacieea - 50%). Oaeei /eiii, cieaeaiiy ?eceeo iani?eyoeeaiai ia?aa?ao o oai?eo c ii/aoeiaith eiai aenieith ?iia??i?noth aoei a??ia?aeii a?eueoei, /ei a a?oi? iaoe??io?a, ye? e?eoaaeeny eiia?iaoe??th aiaeai?eea oa aaeaeaoa SL (p<0.05). AENIIAEE 1. O iaoe??io?a c ?ON, ye? ia?aianee aino?ee ?I, o?eaaea (ia i?ioyc? ?ieo) eiia?iiaaia oa?ai?y aiaeai?eeii ? aaeaeaoii SL a ii??aiyii? c iiiioa?ai??th aiaeai?eeii aai eaioii?eeii ni?ey? a??ia?aeiiio cieaeaiith noia?ii? /anoioe oaeeo ee?i?/ii aaaeeeaeo iiae?e, ye nia?oue, ?a?ioa?eo oa i?ia?anoaaiiy NI ia 20% ? ciaioaiith /anoioe iani?eyoeeaiai i?iaiico ia 31%. 2. Ci?ie e?ioeaai? /anoeie oeoii/eiaiai eiiieaeno AEA, ye? noi?ioaaeenue /a?ac 1 i?nyoeue i?ney ia?aianaiiai ?I, ei?aeththoue c iieacieeaie oeaio?aeueii? aaiiaeeiai?ee ? iiaeooue aooe aeei?enoai? aeey i?iaiicoaaiiy iiaeaeueoiai ia?aa?ao caoai?thaaiiy. 3. O?eaaea canoinoaaiiy o oai?eo ?ON, ye? ia?aianee ?I, eiia?iiaaii? oa?ai?? aiaeai?eeii ? aaeaeaoii SL ni?ey? ciaioaiith aeeeaoaoe?? EO, i?i ui na?ae/eoue a??ia?aeia ciaioaiiy ENI ? EAeI, oa iie?auaiith nei?ioeeai? caeaoiino? i?iea?aea (a??ia?aeiiio i?aeaeuaiith OA EO), a oaeiae noi?iaiaeaeo?oueny iaea?eueo ni?eyoeeaith aeeiai?eith AEA, oiae? ye iiiioa?ai?y aiaeai?eeii noi?iaiaeaeo?oueny o?eueee cieaeaiiyi EAeI EO. 4. Cieaeaiiy a?ia?aeoeaiino? ?AN o iaoe??io?a c ?ON i?ney ia?aianaiiai ?I a?aeaoaa?oueny i?ae aieeaii o?eaaei? oa?ai?? eaioii?eeii aai aiaeai?eeii ? i?iyaey?oueny ciaioaiiyi ai?noo aia?ioaiceia II, oiae? ye i?ae aieeaii oa?ai?? aiaeai?eeii a ii?aeiaii? c aaeaeaoii SL a?aei?/a?oueny cieaeaiiy ye ??aiy aia?ioaiceia II, oae ? aeoeaiino? ?ai?ia ieacie. 5. Aieea o?eaaei? oa?ai?? aaeaeaoii SL o oai?eo ?ON, ye? ia?aianee ?I, ia aeaeo?ie?oiee iai?i i?iyaey?oueny a cieaeaii? ??aiy iao??y a ieaci? e?ia?, eaioii?eeii ? aiaeai?eeii – a i?aeaeuaii? eae?y a ieaci? e?ia?. Eiia?iiaaia oa?ai?y aiaeai?eeii ? aaeaeaoii SL ia aeeaco? iani?eyoeeaiai aieeao ia aeaeo?ie?oiee iai?i. 6. Eiia?iiaaia oa?ai?y aiaeai?eeii ? aaeaeaoii SL i?eaiaeeoue aei iaea?eueo cia/iiai cieaeaiiy i?iaiinoe/iiai ?iaeaeno, yeee ?ic?aoiao?oueny ii oeae? ioe?iee ia?aa?ao caoai?thaaiiy, a ii??aiyii? c iiiioa?ai??th aiaeai?eeii, eaioii?eeii aai aaeaeaoii SL oa noi?iaiaeaeo?oueny cia/iei cieaeaiiyi e?eueeino? oneeaaeiaiue i?ney?ioa?eoiiai ia??iaeo ia i?ioyc? 1 ?ieo niinoa?aaeaiiy. I?AEOE*I? ?AEIIAIAeAOe?? 1. Iaoe??ioai c ?ON, yee ia?aianee aino?ee ?I, oa?ai?y ?AIO iiaea aooe ?aeiiaiaeiaaia aeey caiia?aaiiy ?icaeoeo noaiiea?ae?? ? i?ia?anoaaiith NI; oa?ai?y aiaeai?eeii a aeic? 10 ia ia aeiao a ii?aeiaii? c aaeaeaoii SL a aeic? 40 ia ia aeiao iieacaia iaoe??ioai c aenieei ?eceeii nia?o?, ?icaeoeo ? i?ia?anoaaiiy NI oa/aai ?icaeoeo ?a?ioa?eoa. Oa?ai?y o?eueee aaeaeaoii SL a aeic? 40 ia ia aeiao iiaea aooe aeei?enoaia o iaoe??io?a c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy oa ni?eyoeeaei i?iaiicii. 2. Aiae?c e?ioeaai? /anoeie oeoii/eiaiai eiiieaena AEA iiaea aooe aeei?enoaiei aeey i?iaiicoaaiiy a?aeaeaeaieo ?acoeueoao?a i?ney?ioa?eoiiai ia??iaeo. Oeie AEA: aeaaaoe?y naaiaioa ST, coaaoeue O iaaaoeaiee oa aeaaaoe?y naaiaioa ST, coaaoeue O iiceoeaiee oa?aeoa?ecothoueny a??oeie aaiiaeeiai?/ieie iieacieeaie, /ei oeie AEA: naaiaio ST ia ?cie?i??, coaaoeue O iiceoeaiee oa naaiaio ST ia ?cie?i??, coaaoeue O iaaaoeaiee. 3. Aeniea aeoeai?noue ?AN, yea noi?iaiaeaeo?oueny iani?eyoeeaeie aaiiaeeiai?/ieie ci?iaie, o oai?eo, ye? ia?aianee aino?ee ?I, ? iieacaiiyi aeey i?ecia/aiiy eiia?iiaaii? oa?ai?? aiaeai?eeii a aeic? 10 ia ia aeiao ? aaeaeaoii SL a aeic? 40 ia ia aeiao, oae ye i?ae aieeaii oaeiai caniao e?eoaaiiy a?aeaoaa?oueny iaea?eueo ae?aaeaia cieaeaiiy aeoeaiino? ?AN, ciaioaiiy aeeeaoaoe?? EO (EAeI oa ENI) ? iie?auaiiy nei?ioeeai? caeaoiino? i?iea?aea. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. I.I.Ai?iiiaa. Yeaeo?i- e yoiea?aeeia?aoe/aneea ia?aeeaee o aieueiuo eoaie/aneie aieaciueth na?aeoea, ia?aianoeo ino?ue eioa?eo ieiea?aea. // A?noiee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.- N22.- N.86-88. 2. I.I.Ai?iiiaa. I?eiaiaiea eiaeaeoi?ia aiaeioaicei-i?aa?auathuaai oa?iaioa o aieueiuo eoaie/aneie aieaciueth na?aeoea, ia?aianoeo eioa?eo ieiea?aea (Iaci? eeoa?aoo?u) // A?noiee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.- N23.- N.29-34. 3. E.E.Eaoiaoc, I.I. Ai?iiiaa. Iioeiecaoeey iiaeoiaeia e oa?aiee aioaaiienoaie eaeueoeey o aieueiuo eoaie/aneie aieaciueth na?aeoea, ia?aianoeo ino?ue eioa?eo ieiea?aea. // A?a/aaiay i?aeoeea.- 1999.- N2-3.- N. 82-84. 4. E.E.Eaoiaoc, I.I.Ai?iiiaa. Eciaiaiey aaiiaeeiaie/aneeo iieacaoaeae o aieueiuo ia?aianoeo ino?ue eioa?eo ieiea?aea iiae aeeyieai aeeeoaeueiie oa?aiee eiaeaeoi?aie aiaeioaiceii?aa?auathuaai oa?iaioa. // Iaoa??aee XIV c’?caeo oa?aiaao?a Oe?a?ie. - Ee?a, 1998. – N.182-183. 5. I.I.Ai?iiiaa. I?eiaiaiea yaeieoa o aieueiuo iinoeioa?eoiui ea?aeeineea?icii. // Na. iao/. o?. OAIO “Iiaua ai?eciiou eeeieee aioo?aiieo aieaciae”, Oa?ueeia, 1998.- N. 93-95. 6. I.I.Ai?iiiaa. N?aaieoaeueiay yooaeoeaiinoue aeeeoaeueiie oa?aiee eiaeaeoi?aie AIO, aioaaiienoaie eaeueoeey e eo ni/aoaieai o aieueiuo, ia?aianoeo ino?ue eioa?eo ieiea?aea. // A?a/aaiay i?aeoeea. - 1999.- N4.- N. 41-44. AIIOAOe?ss Ai?iiiaa I.I. Ee?i?ei-aaiiaeeiai?/i? iniaeeaino? ia?aa?ao ?oai?/ii? oai?iae na?oey a i?ney?ioa?eoiiio ia??iae? i?ae aieeaii oa?ai?? aioaaii?noaie eaeueoe?y ? ?ia?a?oi?aie aia?ioaiceiia?aoai?thth/iai oa?iaioa. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. I?iaaaeai? aeine?aeaeaiiy i?enay/ai? aoaeoeaiino? o?eaaei? oa?ai?? oai?eo ?ON, ye? ia?aianee aino?ee ?ioa?eo i?iea?aea, ?ia?a?oi?aie aia?ioaiceiia?aoai?thth/iai oa?iaioa, aioaaii?noaie eaeueoe?th oa ?o ii?aeiaiiyi. Iieacaii, ui eiia?iiaaia oa?ai?y aiaeai?eeii ? aaeaeaoii SL a ii??aiyii? c iiiioa?ai??th aiaeai?eeii ? eaioii?eeii ni?ey? a??ia?aeiiio cieaeaiith noia?ii? /anoioe oaeeo ee?i?/ii aaaeeeaeo iiae?e, ye nia?oue, ?a?ioa?eo ? i?ia?anoaaiiy NI oa ciaioaiith /anoioe iani?eyoeeaiai i?iaiico. Aeyaeaii ciaioaiiy aeeeaoaoe?? e?aiai oeoii/ea ? iie?auaiiy eiai nei?ioeeai? caeaoiino? i?ae aieeaii eiia?iiaaii? oa?ai??. Iieacaii, ui cieaeaiiy a?ia?aeoeaiino? ?ai?i-aia?ioaiceiiai? nenoaie i?ney ia?aianaiiai ?ioa?eoo i?iea?aea a?aeaoaa?oueny i?ae aieeaii o?eaaei? oa?ai?? eaioii?eeii ? aiaeai?eeii ? i?iyaey?oueny ciaioaiiyi ??aiy aia?ioaiceia II, oiae? ye i?ae aieeaii oa?ai?? aiaeai?eeii a ii?aeiaii? c aaeaeaoii SL niinoa??aa?oueny cieaeaiiy ye ??aiy aia?ioaiceia II, oae ? aeoeaiino? ?ai?ia ieacie. E??i oeueiai, eiia?iiaaia oa?ai?y ia ia? iaaaoeaiiai aieeao ia aeaeo?ie?oiee iai?i. Eeth/ia? neiaa: ?oai?/ia oai?iaa na?oey, ?ioa?eo i?iea?aea, aioaaii?noe eaeueoe?y, ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioa, oeaio?aeueia aaiiaeeiai?ea, ?ai?i, aia?ioaicei II, i?iaiic. AIIIOAOeEss Ai?iiiaa I.I. Eeeieei-aaiiaeeiaie/aneea iniaaiiinoe oa/aiey eoaie/aneie aieacie na?aeoea a iinoeioa?eoiii ia?eiaea iiae aeeyieai oa?aiee aioaaiienoaie eaeueoeey e eiaeaeoi?aie aiaeioaiceii?aa?auathuaai oa?iaioa. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey. Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. I?iaaaeaiiua enneaaeiaaiey iinayuaiu yooaeoeaiinoe aeeeoaeueiie oa?aiee aieueiuo EAN, ia?aianoeo ino?ue eioa?eo ieiea?aea, eiaeaeoi?aie aiaeioaiceii?aa?auathuaai oa?iaioa, aioaaiienoaie eaeueoeey e eo ni/aoaieai. Iieacaii, /oi eiiaeie?iaaiiay oa?aiey yiaeai?eeii e aaeaeaoii SL ii n?aaiaieth n iiiioa?aieae yiaeai?eeii e eaioii?eeii niinianoaoao aeinoiaa?iiio nieaeaieth noiia?iie /anoiou oaeeo eeeie/anee aaaeiuo niauoee, eae nia?oue, ?aeioa?eo e i?ia?anne?iaaiea NI. Oae, /a?ac 12 ianyoeaa /anoioa yoeo niauoee a a?oiia iaoeeaioia, iieo/aaoeo eaioii?ee ninoaaeea 26.7% (p<0.05 a n?aaiaiee n a?oiiie, iieo/aaoeo aaeaeao SL), n?aaee iieo/aaoeo aaeaeao SL - 53.3%, n?aaee iieo/aaoeo yiaeai?ee - 20% (p<0.01 a n?aaiaiee n iieo/aaoeie aaeaeao SL) e n?aaee iieo/aaoeo aaeaeao SL e yiaeai?ee - 6.7% (p<0.01 a n?aaiaiee n a?oiiie, iieo/aaoeo aaeaeao SL e p<0.05 a n?aaiaiee n a?oiiie, iieo/aaoeo eaioii?ee). Aiaeec eiia/iie /anoe aeaeoaei/eiaiai eiiieaena YEA iicaieee auaeaeeoue 4 oeia YEA o iaoeeaioia n ia?aaeiae eieaeecaoeeae EI (n=72): oei A - (ST ia ecieeiee, O io?eoeaoaeueiue); oei A - (yeaaaoeey ST, O io?eoeaoaeueiue); oei N - (ST ia ecieeiee, O iieiaeeoaeueiue); oei D - (yeaaaoeey ST, O iieiaeeoaeueiue). I?e yoii oei A ?aaeno?e?iaaeny o 29 (40.3%), oei A - 13 (18.1%), oei N - 10 (13.9%), oei D - o 20 (27.7%) iaoeeaioia. Eciaiaiey YEA oeia B e D annioeee?iaaeenue n ooaeoeie iieacaoaeyie aioo?ena?aea/iie aaiiaeeiaieee, /ai YEA oeia A e C, /oi iicaieeei iauaaeeieoue aeaiiua a?oiiu, eae iaaeaaii?eyoiua a aaiiaeeiaie/aneii ioiioaiee (YEA oei B+D) e aeaaii?eyoiua (YEA oei A+C). *anoioa "iaaeaaii?eyoiuo" a i?iaiinoe/aneii ieaia oeiia YEA a a?oiia iieo/aaoeo eaioii?ee oiaiueoeeanue n 47.1% aei 11.8%, p<0.05; a a?oiia iieo/aaoeo aaeaeao SL - n 36.8% aei 31.5%, p>0.2; a a?oiia ea/aiiuo
yiaeai?eeii — n 50.0% aei 11.1%, p<0.01 e a a?oiia ea/aiiuo eiiaeie?iaaiiie oa?aieae n 50% aei 5.6%, p<0.01. I?e enoiaeiii ionoonoaee ?acee/ee iaaeaeo a?oiiaie a eiee/anoaa iaoeeaioia n "iaaeaaii?eyoiuie" oeiaie YEA, iinea ea/aiey ?acee/ey iaaeaeo a?oiiaie iaoeeaioia, ea/aiiuo oieueei aioaaiienoaie eaeueoeey e ni/aoaieai EAIO n aioaaiienoaie eaeueoeey noaiiayony noaoenoe/anee cia/eiuie (p<0.05). Auyaeaii oiaiueoaiea aeeeaoaoeee eaaiai aeaeoaei/ea (nieaeaiea EAeI n 97.5+21.8 ie aei 92.4+25.4 ie, p<0.05) e oeo/oaiea aai nie?aoeoaeueiie niiniaiinoe (oaaee/aiea OA n 50.8+14.5% aei 55.2+14.1%, p<0.05) iiae aeeyieai eiiaeie?iaaiiie oa?aiee. Iieacaii, /oi nieaeaiea aeia?aeoeaiinoe ?aiei-aiaeioaiceiiaie nenoaiu iinea ia?aianaiiiai eioa?eoa ieiea?aea i?ienoiaeeo iiae aeeyieai aeeeoaeueiie oa?aiee eaioii?eeii e yiaeai?eeii e i?iyaeyaony oiaiueoaieai o?iaiy aiaeioaiceia II (n 5.7+1.7 ia/ie aei 4.2+1.3 ia/ie, ?<0.001 e n 6.0+1.8 ia/ie aei 4.1+1.4 ia/ie, ?<0.001, niioaaonoaaiii), oiaaea eae iiae aeeyieai oa?aiee yiaeai?eeii a ni/aoaiee n aaeaeaoii SL iaaethaeaaony nieaeaiea eae o?iaiy aiaeioaiceia II (n 5.8+1.7 ia/ie aei 3.7+1.1 ia/ie, ?<0.001), oae e aeoeaiinoe ?aieia ieaciu (n 4.8+1.5 ia/ie// aei 3.6+0.9 ia/ie//, ?<0.001). Aeinoiaa?iia eciaiaiea niaea?aeaiey yeaeo?ieeoia a ieacia i?ienoiaeeei a a?oiia iieo/aaoeo aaeaeao SL ca n/ao nieaeaiey o?iaiy ieaciaiiiai iao?ey n 145+15.4 iiieue/e aei 135+19.4 iiieue/e (p<0.05) e a a?oiiao, iieo/aaoeo eaioii?ee e yiaeai?ee, ca n/ao iiauoaiey o?iaiy eaeey ieaciu: n 4.0+0.8 iiieue/e aei 4.6+1.2 iiieue/e (p<0.05) e n 4.1+0.9 iiieue/e aei 4.6+1.0 iiieue/e (p<0.05), niioaaonoaaiii. Eiiaeie?iaaiiay oa?aiey yiaeai?eeii e aaeaeaoii SL ia ieacuaaea aeeyiey ia yeaeo?ieeoiue aaeain. I?e ?an/aoa i?iaiinoe/aneiai eiaeaena ii oeaea ?enea iaaeaaii?eyoiiai enoiaea a a?oiiao, ea/aiiuo eaioii?eeii eee yiaeai?eeii, auei auaeaeaii 37 aieueiuo n iaaeaaii?eyoiui i?iaiicii, n?aaeiee i?iaiinoe/aneee eiaeaen i?e yoii ninoaaee 21%. A a?oiia iaoeeaioia, ea/aiiuo eiiaeie?iaaiiie oa?aieae, auei 19 oaeeo iaoeeaioia, n?aaeiee i?iaiinoe/aneee eiaeaen ninoaaee 22%. E 12 ianyoeai ea/aiey, a a?oiia iaoeeaioia, iieo/aaoeo EAIO, aeaiiue i?iaiinoe/aneee eiaeaen nieceeny aei 17% (ioiineoaeueiia nieaeaiea iieacaoaey i?e yoii ninoaaeei 19%). O iaoeeaioia, ea/aiiuo eiiaeiaoeeae EAIO e aioaaiienoa eaeueoeey, i?iaiinoe/aneee eiaeaen e 12 ianyoeai ninoaaee 11% (ioiineoaeueiia nieaeaiea iieacaoaey ninoaaeei 50%). Oaeei ia?acii ioiineoaeueiia nieaeaiea ?enea iaaeaaii?eyoiiai enoiaea o iaoeeaioia n enoiaeii aunieie aai aa?iyoiinoueth auei aeinoiaa?ii aieueoei a a?oiia ea/aiiuo eiiaeiaoeeae yiaeai?eea e aaeaeaoa SL (p<0.05). Eeth/aaua neiaa: eoaie/aneay aieaciue na?aeoea, eioa?eo ieiea?aea, aioaaiienou eaeueoeey, eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa, oeaio?aeueiay aaiiaeeiaieea, ?aiei, aiaeioaicei II, i?iaiic. ANNOTATION Voronova N.N. Clinical and hemodynamic features of coronary artery disease in postinfarction period under influence of the treatment by calcium antagonist and angiotensin-converting enzyme inhibitors. – Manuscript. Thesis on competition of a scientific degree of the candidate of medical science on the speciality 14.01.11 – cardiology. Kharkov state medical university, Kharkov, Ukraine, 1999. The conducted research are devoted to study efficacy long-term therapy in patients with coronary artery disease, which survived after acute myocardial infarction, with angiotensin-converting enzyme inhibitors, calcium antagonist and its combination. Were shown that combination of captopril and adalat SL in comparison with monotherapy by enalapril or captopril leads to significant decrease frequency of clinical important events – death, reinfarction and progression of heart failure. Was found decreasing of dilatation of left ventriculi and improving its contractility with combination therapy. Decreasing of angiotensin II level after myocardial infarction was found in captopril and enalapril groups. In the group of combined therapy inhibition of renin-angiotensin system was maximal and include declining both renin and angiotensin II levels. Moreover, combined therapy have not negative influence on electrolytes levels. Key words: coronary artery disease, myocardial infarction, calcium antagonist, angiotensin-converting enzyme inhibitors, central hemodynamic, renin, angiotensin, prognosis.

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