9

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa

?ioaeoe?eieo oai?ia ?iai? E.A.A?iiaoaanueeiai

EEEIAIEI AEAIIA AI?EN?AIA

OAeE 616.36 — 002.1/2 — 036.22 — 071

EE?I?EI-AI?AeAI?IEIA?*I? INIAEEAINO? AAIAOEOO N

14.01.13 — ?ioaeoe?ei? oai?iae

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a-1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?iai? E.A.A?iiaoaanueeiai.

Iaoeiaee ea??aieeaeieoi? iaaee/ieo iaoe AIAE Aeea Aeieo??aia, caa?aeoaa/
ee?i?ee a??oniiai aaiaoeoo c aeieii NI?Aeo Ee?anueeiai IAe?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?iai? E.A.A?iiaoaanueeiaiIaoeiaee
eiinoeueoaioaeieoi? iaaee/ieo iaoe AO?AEUe Aiaoie?e Eaiio?eiae/,
caa?aeoaa/ eaai?aoi??? ai?aeai?ieia?? oa i?io?eaeoeee a??oniiai aaiaoeoo
Ee?anueeiai IAe? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?iai?
E.A.A?iiaoaanueeiai

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? EE?E*AIEI Aeieo?i Oaaei?iae/,
caa?aeoaa/ eaoaae?e ?ioaeoe?eieo oai?ia A?iieoeueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. I.?.Ie?iaiaa,

aeieoi? iaaee/ieo iaoe, i?ioani? I?E?O?I ?aaai Aaneeueiae/, caa?aeoaa/
eaoaae?e ?ioaeoe?eieo oai?ia Iaeanueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo

I?ia?aeia onoaiiaa

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie

Caoeno a?aeaoaeaoueny ’’ 31 ’’ aa?aciy 1999 ?ieo ia 11-00 aiaeei? ia
can?aeaii? Niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?iai? E.A.A?iiaoaanueeiai ca aae?anith: 252015, i. Ee?a — 15, aoe.
N?/iaaiai iianoaiiy, 23

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?iai? E.A.A?iiaoaanueeiai IIC Oe?a?ie.

Aaoi?aoa?ao ?ic?neaii ’’ 28 ’’ ethoiai 1999 ?ieo.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe _______________________Aiae A.Ae.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. A??oni? aaiaoeoe a?aeiinyoueny aei oai?ia, ye?
a cia/i?e i??? aecia/athoue caoai?thaai?noue ? nia?oi?noue a na?o?.
Ui??/ii iia? nioi? oeny/ ethaeae ?io?eothoueny, noathoue ?iaae?aeaie, a
oeny/? iiie?athoue a?ae iani?eyoeeaeo iane?aee?a (Aiae?ae/ei I.A. c?
ni?aaao., 1988; Aiae A.Ae., 1990; Aaaao A.A. c? ni?aaao., 1990; Ao?aeue
A.E., 1996; Aic?aiiaa AE.?., 1997; A?iiaoaanueea E.E., 1998).

Aaiaoeo N /AN/, a?aeiiee ?ai?oa i?ae iacaith «aaiaoeo i?-A, i?-A» c
ia?aioa?aeueiei iaoai?ciii ia?aaea/?, a??on yeiai aoa ?aeaioeo?eiaaiee a
1989 ?. Houghton ? ni?aaao., i?eaa?ioa aei naaa cia/io oaaao, ? a
oaia??oi?e /an ? aaaeeeaith ? aeooaeueiith i?iaeaiith iaaee/ii? iaoee oa
ioi?iie caei?ia’y, yea aeeoea ia iaeia c i?ia?aeieo i?noeue a
?ioaeoe?ei?e iaoieia??. Aeooaeuei?noue i?iaeaie aecia/a?oueny a ia?oo
/a?ao oe?ieei ?iciianthaeaeaiiyi AN. Ca?aeii ?ic?aooieiaei aeaiei, a
na?o? ?io?eiaaii HCV 500 iei. /ieia?e, ui aeinyaa? 10 % an??? iiioeyoe??
(Sherlock Sh., 1995). I?eioneathoue, ui a iaaeaeaeiio iaeaooiueiio
iioe?aiiy AN ae?inoa a aeanyoee ?ac?a (Ni??inii N.I., 1996). Ia
nueiaiaei?oi?e aeaiue AN noa? ana a?eueo aaaeeeaith
iaaeeei-nioe?aeueiith i?iaeaiith, cia/ei?noue yei? iaoiiaeaia oaeiae
aenieith /anoioith o?ii?caoe?? i?e /anoi eaoaioiiio ia?aa?ao aino?eo
oi?i oai?iae. O 50 % — 80 % oai?eo oi?io?oueny o?ii?/iee aaiaoeo N
(OAN), o 20 % — 30 % — oee?ic ia/?iee (OeI) oa aaiaoioeaethey?ia
ea?oeeiiia (AOeE) (Iiaeeiiaa N.A., 1996). Onoaiiaeaii, ui o 61,7 % —
81,4 % oai?eo c ia?aeiiei ?aeii ia/?iee aeyaeyeenue aioeo?ea aei a??ono
aaiaoeoo N (aioe-HCV) (Aioyeia A.?. c? ni?aaao., 1996; World health
Rep., 1996; Roguier — Charles D., 1996; Eueaia Ae.E., 1997).

Ia aeeaey/enue ia oa, ui ca inoaii?e /an aeine?aeaeaiiy AN o ??cieo
iai?yieao cia/ii ?ioaineo?eoaaeinue, ea?aeeiaeuei? ieoaiiy ee?i?ee,
ai?aeai?ieia??, iaoiaaiaco, e?eoaaiiy a ?o aca?iica’yceo caeeoathoueny
aei e?ioey iaynieie ? iio?aaothoue iiaeaeueoi? ?ic?iaee.

A Oe?a?i? AN ciaoiaeeoueny ia ii/aoeia?e noaae?? aea/aiiy. A?aoiaoth/e
aaaeeea?noue i?iaeaie, iaaeinoaoith ?? aea/ai?noue, ?, aieiaiei /eiii
oa, ui oai?iae, a o. /. ? ?ioaeoe?ei?, a ca’yceo c aeieia?/ieie oiiaaie
iathoue nai? iniaeeaino?, iao? aeine?aeaeaiiy aoee i?enay/ai? oe?e
aeooaeuei?e oai?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia a ieai? caaaeueii? i?ia?aie aeine?aeaeaiue ii i?iaeai?
«A??oni? aaiaoeoe», ? /anoeiith ieaiiai? iaoeiai-aeine?aeii? ?iaioe
«Aea/eoe ee?i?/i?, ai?aeai?ieia?/i?, a?io?i?/i?, ?ioiieia?/i?
iniaeeaino? ia?aa?ao AN, eiai aeeoa?aioe?eio ae?aaiinoeeo, ?ic?iaeoe
i?eioeeie e?eoaaiiy c iaoith iiia?aaeaeaiiy iani?eyoeeaeo iane?aee?a»,
yea aeeiioaaeanue o Ee?anueeiio IAe? ai?aeai?ieia?? oa ?ioaeoe?eieo
oai?ia ?iai? E.A.A?iiaoaanueeiai IIC Oe?a?ie (EIAe?A?O).

Iaoa ? caaaeaiiy aeine?aeaeaiiy

C’ynoaaoe ai?aeai?ieia?/i? iniaeeaino?, aa??aioe ee?i?/iiai ia?aa?ao,
a?io?i?/ieo c?ooaiue, ?ioiieia?/ieo iieaciee?a o oai?eo ia aino?ee oa
o?ii?/iee aaiaoeo N.

Aeey aeinyaiaiiy aeacaii? iaoe aoee iinoaaeai? ne?aeoth/? iniiai?
caaea/?:

1. I?iaanoe ai?aeai?ieia?/iee aiae?c o oai?eo ia aino?ee aaiaoeo N
(AAN) oa OAN.

2. Aea/eoe ee?i?/iee ia?aa?a, a?io?i?/i? oa ?ioiieia?/i? iieacieee o
oai?eo ia AAN.

3. Ioa?aeoa?ecoaaoe OAN: ee?i?/io ea?oeio, a?io?i?/i? oa ?ioiieia?/i?
iieacieee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Ia iniia? i?iaaaeaieo niinoa?aaeaiue i?e eiiieaeniiio aeei?enoaii?
ee?i?/ieo, ai?aeai?ieia?/ieo, a?io?i?/ieo, ?ioiieia?/ieo iaoiae?a ?c
canoinoaaiiyi aeniei/ooeeaeo oano?a aecia/aiiy ia?ea??a AN (aioe-HCV a
?ioiioa?iaioiiio aiae?c? (?OA), HCV-RNA a iie?ia?aci?e eaioethaia?e
?aaeoe?? (IE?), onoaiiaeai? oaeoi?e, ui ni?eyee ?io?eoaaiith a??onii AN
(HCV), na?aae yeeo oeaio?aeueia i?noea caeiaee e?eoaaeueii-ae?aaiinoe/i?
iaaee/i? ao?o/aiiy oa aioo??oiueiaaiia aaaaeaiiy ia?eioe/ieo ?a/iaei.
Ioa?aeoa?eciaai? ee?i?ei-a?io?i?/i? aa??aioe ia?aa?ao aino?iai oa
o?ii?/iiai AN, aeyaeai? aeeoa?aioe?eii-ae?aaiinoe/i? iniaeeaino? AN.

I?aeoe/ia cia/aiiy ?iaioe

Onoaiiaeai? iniiai? oeyoe ? oaeoi?e ?io?eoaaiiy oai?eo ia AN, ui
aecia/athoue iniiai? iai?yiee i?io?eaeoe/ieo oa i?ioeai?aeai?/ieo
caoiae?a, ye? ni?yiiaai? ia ia?a?eaaiiy iaoai?ci?a ooo/iiai
ia?aioa?aeueiiai ?io?eoaaiiy i?e i?iaaaeaii? iaaee/ieo iai?ioeyoe?e ?
aioo??oiueiaaiiiai aaaaeaiiy ia?eioe/ieo ?a/iaei.

Io?eiai? aeai? i?i ee?i?/io ea?oeio ??cieo aa??aio?a AAN, OAN ?
a?io?i?/i? iieacieee, ye? ?o oa?aeoa?ecothoue oa canoiniaothoueny
iae/ano?oa ia i?aeoeoe? (aeoeai?noue AeAO, eiioeaio?aoe?y a?e??oa?io,
ai?no aeueaoi?io ? aaiaaeiaoe?i?a oa ?i.), iiaeooue i???iooaaoe
i?aeoe/ieo e?ea??a i?e aeeoa?aioe?ei?e ae?aaiinoeoe? aaiaoeo?a ?
ioe?ioe? oyaeeino? AN.

Iniaenoee aianie caeiaoaa/a

Aaoi?ii ia?niiaeueii i?iaiae?ciaaia iaoeiaa e?oa?aoo?a c
aeine?aeaeoaaii? i?iaeaie, i?iaaaeaiee ?ioi?iaoe?eiee iiooe, naiino?eii
aeeiiaia ee?i?/ia oa ai?aeai?ieia?/ia ianoaaeaiiy oai?eo, i?iaiae?ciaai?
aeai? eaai?aoi?ieo oa ?ino?oiaioaeueieo aeine?aeaeaiue, iaienai? an?
?icae?ee ?iaioe, noi?ioeueiaai? aeniiaee oa i?aeoe/i? ?aeiiaiaeaoe??.
Iniaenoee aianie caeiaoaa/a a ?iaioao, iaae?oeiaaieo ?c ni?aaaoi?aie,
noaiiaeoue 50 %.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iaoa??aee aeena?oaoe?eii? ?iaioe aoee aeeeaaeai? oa iaaiai?ai? ia
can?aeaiiyo Ee?anueeiai iaeaniiai iaoeiaiai oiaa?enoaa ?ioaeoe?ii?no?a
(1996, 1997, 1998 ??.), ia ia?aae? aieiaieo ?ioaeoe?ii?no?a oa
caa?aeoth/eo eaoaae?aie ?ioaeoe?eieo oai?ia (i. sseoa, 1996), ia
iaoeiai-i?aeoe/i?e eiioa?aioe?? ? Ieaioi? Anioe?aoe?? ?ioaeoe?ii?no?a
(i. Noie, 1997), ia Ieaioi? Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie (i.
Ioea/aai, 1998?.). Ai?iaaoe?y aeena?oaoe?? a?aeaoeany 24.12.98?. ia
can?aeaii? Ai?iaaoe?eii? ?aaee ee?i?/iiai a?aeae?eo EIAe?A?O.

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 13 iaoeiaeo ?ia?o, c
ieo 4 o aeaeaiiyo, ye? aecia/ai? AAEii Oe?a?ie o yeino? oaeeo, aea
iiaeooue aooe iioae?eiaai? iaoa??aee eaiaeeaeaonueeeo ? aeieoi?nueeeo
aeena?oaoe?e.

No?oeoo?a oa ia’?i aeena?oaoe??

?iaioa aeeeaaeaia ia 140 noi??ieao iaoeiiieniiai oaenoo, neeaaea?oueny
?c anooio, iaeyaeo e?oa?aoo?e, ?icae?eo caaaeueiiee?i?/ieo oa
niaoe?aeueieo iaoiae?a aeine?aeaeaiiy oai?eo, 5 ?icae?e?a aeanieo
aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, nieneo aeei?enoaieo aeaea?ae,
i?noeoue 28 oaaeeoeue, 8 ?enoie?a.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiue

?iaioa aeeiioaaeanue o ee?i?/iiio a?aeae?eaii? a??onieo aaiaoeo?a
EIAe?A?O oa o eaai?aoi??yo ee?i?/ii? a?io?i??, ai?aeai?ieia?? oa
i?io?eaeoeee a??onieo aaiaoeo?a, ?ioiieia??.

Aeey aeeiiaiiy iinoaaeaieo caaea/ iaie ianoaaeaii 284 oai?eo ia AN,
na?aae yeeo o 74 aoa AAN, o 64 — aaiaoeo A+N, o 146 — OAN. Ia?aaaaeaee
iniae iieiaeiai a?eo aei 30 ?ie?a (65,2 %). Na?aae ianoaaeaieo oai?eo
190 ciaoiaeeeenue ia noaoe?iia?iiio e?eoaaii? ? 94 niinoa??aaeenue
iie?ee?i?/ii (aeiii?e noaioe?? ia?aeeaaiiy e?ia? c noaee?i?/iith ?
?iaia?aioiith oi?iaie OAN). Oai?? ia AAN ia?aaoaaee a noaoe?iia?? 3-4
oeaei?, ca a?eueoith /anoeiith c ieo i?ney aeienee c noaoe?iia?o a?any
?aoaeueiee iaaeyae i?ioyaii 1 ?ieo ? a?eueoa. Oai?? ia OAN
niinoa??aaeenue iaie 2 — 4 ?iee.

Ae?aaiic oai?iae iaa?oioiaoaaee ia iniia? niaoeeo?/ieo iaoiae?a,
ee?i?ei-ai?aeai?ieia?/ieo aeaieo, ?acoeueoao?a a?io?i?/iiai ianoaaeaiiy
oai?eo, OC aeine?aeaeaiiy.

Niaoeeo?/io eaai?aoi?io ae?aaiinoeeo cae?enithaaee oeyoii aecia/aiiy
aioe — INV o ne?iaaooe? e?ia?, ia?ea??a aino?i? oace aaiaoeoo A (AA)
(IAsAg, aioe-HBnIgM) ca aeiiiiiaith ?OA. O /anoeie oai?eo aeyaeyee HCV —
RNA (IE?), aioeo?ea aei iano?oeoo?ieo a?ee?a NS4, NS5 iaoiaeii
oaa?aeioaciiai ?OA. Aeei?enoiaoaaee no/ani? oano — nenoaie ae?iaieoeoaa
IAI «Ae?ai?io Iaae» (Oe?a?ia), IAI «Aeeaaiinoe/aneea nenoaiu» (?in?y),
o??ie «Sanofi Diagnostics Pasteur» (O?aioe?y), “Orgenics Ltd”
(?c?a?eue). AAN ae?aaiinooaaee i?e aeyaeaii? o oai?eo aioe-INV,
a?aenooiino? ia?ea??a aino?i? oace AA. Ae?aaiic OAN onoaiiaethaaee i?e
ee?i?ei-eaai?aoi?i?e neiioiiaoeoe? aaiaoeoo o?eaae?noth a?eueoa 1 ?ieo ?
aeyaeaii? aioe-HCV o ne?iaaooe? e?ia? oai?eo, cie?aia aei iano?oeoo?ieo
a?ee?a NS4, NS5, i?e a?aenooiino? ia?ea??a AA ? aeaeueoa, iayai?noth
HCV-RNA o ne?iaaooe? e?ia? oai?eo. O ianoaaeaieo in?a aeeeth/aeenue an?
?io? i?e/eie, caeaoi? i?eaanoe aei o?ii?/iiai o?aaeaiiy ia/?iee
(oiene/i?, aeeiaieuei? aaiaoeoe oa ?i.).

E??i oiai, i?e aeeiiaii? ?iaioe aeei?enoiaoaaeenue oae? iaoiaee:
aecia/aiiy eiioeaio?aoe?? na?aaei?o iieaeoe «NI» ii iaoiaeo I?eieae/eea
? ni?aaao. (1991), aeoeaiino? AeAO o oe?euei?e ? a 10 ?ac ?icaaaeai?e
o?c?ieia?/iei ?ic/eiii ne?iaaoee, ye iienaii E.E.A?iiaoaanueeith (1968,
1979), ai?no a?e??oa?io ca Aiae?aneeii — A?ioii oi?o?eiaaiei iaoiaeii.
Ianoaaeaiiy oai?eo ia AAN ? OAN i?iaiaeeeenue i?ae /an ia?aaoaaiiy ?o ia
noaoe?iia?iiio e?eoaaii? — eiaeai oeaeaeaiue, i?e i?neynoaoe?iia?iiio
niinoa?aaeaii? — eiaei? 2-3 i?nyoe?. OCAe i?aai?a /a?aaii? ii?iaeieie
cae?enithaaeenue a aeeiai?oe? iaaeyaeo ca oai?eie aia?aoii «Aloka
SSD-500» (ssiii?y).

Na?aae ?ioiieia?/ieo iieaciee?a aecia/aee iniiai? iiioeyoe?? ?
noaiiioeyoe?? e?ioioeeo?a ia?eoa??eii? e?ia? iaoiaeii eiia?iiaaiiai
?icaoeiooai?aiiy (N. Mendes, 1974; S.Limatibul, 1976); eiioeaio?aoe?th
?ioiiaeiaoe?i?a A, G, I o ne?iaaooe? e?ia? aecia/aee ii iaoiaeo
?aae?aeueii? ?ioiiaeeooc?? a aae? ca aeiiiiiaith iiiiniaoeeo?/ieo
ne?iaaoie ae?iaieoeoaa IAe?A ?i. I.O.Aaiaea?.

Noaoenoe/io ia?iaeo io?eiaieo aeaieo i?iaiaeeee c aeei?enoaiiyi iaoiae?a
aa??aoe?eii? noaoenoeee (Eai?inueeee E.N., 1964; ?oioeinueeee E.C.,
1971).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

I?iaaaeai? na?iai?aeai?ieia?/i? aeine?aeaeaiiy iieacaee, ui na?aae
oai?eo ia a??oni? aaiaoeoe, aini?oae?ciaaieo o EIAe?A?O, ieoiia aaaa AN
neeaea 18,5 %.

Iaoa??aee ai?aeai?ieia?/iiai aiae?co na?ae/aoue i?i oa, ui iaea?eueoa
cia/aiiy a ?io?eoaaii? a??onii AN iaee ooo/i? ia?aioa?aeuei? ao?o/aiiy,
ye? aeeth/aee e?eoaaeueii-ae?aaiinoe/i? iaaee/i? iai?ioeyoe?? (49,4 %)
oa aioo??oiueiaaiia aaaaeaiiy ia?eioe/ieo ?a/iaei (32,7 %).

Aiae?c no?oeoo?e iaaee/ieo ia?aioa?aeueieo iai?ioeyoe?e, ye? neoaeeee
oaeoi?ii ia?aaea/? caoaeieea AN iieacaa (?en. 1), ui o oai?eo ia AAN,
OAN oa aaiaoeo A+N (anueiai190 in?a) aiie ?iciiae?eeeenue oaeei /eiii:
aaiio?ainooc?? — 16,3 %, ?i’?eoe?? e?ea?nueeeo oa ae?aaiinoe/ieo
i?aia?ao?a — 13,2 %, iia?aoeai? ao?o/aiiy — 8,4 %, e?eoaaiiy o
noiiaoieiaa — 11,0 %, a?iaeieia?/i? ianoaaeaiiy — 0,5 %. O 17,9 % oai?eo
eiie?aoi? oeyoe ?io?eoaaiiy ia onoaiiaeai?.

Aioo??oiueiaaiia aaaaeaiiy ia?eioe/ieo ?a/iaei iae/ano?oa a?aei?/aeinue
i?e aaiaoeo? A+N (40.6 %). Na?aae ianoaaeaieo iaie oai?eo ia AAN oeae
oeyo

?en. 1. Iniiai? oaeoi?e ?io?eoaaiiy oai?eo ia AN.

?io?eoaaiiy cono??/aany cia/ii /ano?oa, i?ae o oai?eo ia aino?ee aaiaoeo
A (AAA) (35 % ? 15,9 % a?aeiia?aeii, ?<0,05). Ioaea, ia iniia? i?iaaaeaiiai ai?aeai?ieia?/iiai aiae?co, iiaeia aeae?eeoe oae? iniiai? e?eoa???, ui aeathoue ciiao cai?aeic?eoe AN: - iayai?noue a aiaiiac? iia?aoeaieo ao?o/aiue, o?eaaeeo eo?n?a ?i’?eoe?eii? oa?ai??, aaiio?ainooc?e, aiaeineii?/ieo ianoaaeaiue ? o. ?i.; - aioo??oiueiaaiia canoinoaaiiy ia?eioe/ieo ?a/iaei, iaaii?yaeeiaai? aiii- ? aaoa?inaenoaeuei? eiioaeoe; - a?e oai?eo - a?ae 18 aei 30 ?ie?a; - ia?aaaaeii /ieia?/a noaoue. I?e aea/aii? ee?i?/ieo iniaeeainoae o oai?eo ia AN aoei onoaiiaeaii, ui o?eaae?noue ?ieoaaoe?eiiai ia??iaeo cia/ii aa??thaaea ? a na?aaeiueiio neeaea 75,0±13,8 aei?a, i?e/iio o oai?eo, ye? iaee a aiaiiac? ia?aeeaaiiy e?ia? - 38,3±7,8 aei?a. Aeine?aeaeaiiy i?iaaaeai? o 74 oai?eo ia AAN, na?aae yeeo o 16 (21,6 %) ae?aaiinoiaaia aacaeiaoyie/ia, o 44 (59,5 %) - eaaea, o 8 (10,8 %)- na?aaeiuei? oyaeeino?, o 6 (8,1 %) - oyaeea oi?ie oai?iae. Ioaea, AAN /ano?oa oa?aeoa?ecoaaany eaae?noth ee?i?/ieo i?iya?a (81,1 % neeaee aacaeiaoyie/i? ? eaae? oi?ie). Oai?iaa, ye i?aaeei, ii/eiaeanue iinooiiai (71,6 %). Iaea?eueo /anoeie aa??aioaie ia?aaeaeiaoyie/iiai ia??iaeo aoee anoaii-aaaaoaoeaiee (27,6 %), ci?oaiee (25,9 %) oa aeeniaioe/iee (24,1 %). O?eaae?noue ia?aaeaeiaoyie/iiai ia??iaeo AAN neeaea a na?aaeiueiio 4,2±0,5 aei?a. C iiyaith aeiaoyieoe? ?ioieneeaoe?eiee neiae?ii aoa neaaeiae?aaeaiei (82,9 %). Ee?i?/ia neiioiiaoeea o oai?eo ia AAN i?aaenoaaeaia a oaae 1. Na?aae Oaaeeoey 1. Ee?i?/ia neiioiiaoeea o oai?eo ia aino?ee oa o?ii?/iee aaiaoeo N Ee?i?/i? iciaeeAAN n = 74OAN n = 40e?euee?noue oai?eoaan /enei %aan /enei %Caaaeueia neaae?noue Oaeaeea noiieai?noue ? cieaeaiiy i?aoeacaeaoiino? Iia??oaiiy aiaoeoo Aieiaiee a?eue I?aeaeuaiiy t0 o?ea A?o?aea?? Ioaeioa Aethaaiiy Noo?noue ? a??eioa a ?ioia?e ii?iaeiei? Aaaee?noue o i?aaiio i?ae?aaa?’? A?eue o i?aaiio i?ae?aaa?’? Nooaeiaiiy Iaoai?eci AEiaoyieoey - oaeeaiiae?aia - iino?eia - ia a?aei?/aeanue Naa?a?iiy oe??e Oaeaaia?iaeoac?? Iaeueia?ia a??oaia Aaii?aa?/iee neiae?ii Iaa?yei-anoeeoe/iee neiae?ii Ca?eueoaiiy ia/?iee aei 3,0 ni a?eueoa 3,0 ni Ca?eueoaiiy naeac?iee65 32 12 16 10 31 7 14 26 27 58 16 7 63 11 4387,8 43,2 16,2 21,6 13,5 41,9 9,5 18,9 35,1 36,5 78,4 21,6 9,5 85,1 14,9 58,140 22 13 12 6 6 15 2 19 19 18 5 4 18 11 7 22 6 15 15 8 8 27 13 26100 55,0 32,5 30,0 15,0 15,0 37,5 5,0 47,5 47,5 45,0 12,5 10,0 45,0 27,5 17,5 55,0 15,0 37,5 37,5 20,0 20,0 67,5 32,5 65,0ee?i?/ieo neiioii?a iae/ano?oa niinoa??aaeenue: caaaeueia neaae?noue (87,8 %), cieaeaiiy aiaoeoo (43,2 %), ioaeioa (41,9 %), aaaee?noue o i?aaiio i?ae?aaa?’? (35,1 %), a?eue o i?aaiio i?ae?aaa?’? (36,5 %). I?aeaeuaiiy oaiia?aoo?e o?ea niinoa??-aaeinue o 21,6 % in?a. Ca?eueoaiiy ?ici???a ia/?iee aoei o an?o oai?eo, /ano?oa anueiai aiia aenooiaea c-i?ae e?ath ?aa?iai? aeoae aei 3 ni (85,1 %), nieaiiiaaae?y a?aei?/aeanue o 58,1 %. O?eaae?noue aeiaoyie/iiai ia??iaeo neeaea i?e eaae?e oi?i? 17,5±1,8 aei?a, i?e na?aaeiuei? oyaeeino? - 38,5±7,5 aei?a, i?e oyaee?e - 57,0±12,6 aei?a, oiaoi a?aeiia?aeaea oi?i? oyaeeino? oai?iae. I?e aeienoe? c noaoe?iia?o o oai?eo niinoa??aaeenue aeaye? caeeoeia? yaeua: anoaii-aaaaoaoeaiee neiae?ii (AAN) (28,4 %), ca?eueoaiiy ?ici???a ia/?iee (64,9 %), nieaiiiaaae?y (27 %), iaeaea o iieiaeie oai?eo - aeeni?ioa?iai?y (a?ia?aaiaaeiaoe?iai?y, a?iiaeueaoi?iai?y), ye iciaee ii?ooaiiy a?eeiai-neioaoe/ii? ooieoe?? ia/?iee ? aeoeaiino? iacaio?iaeueii-caiaeueiiai i?ioeano - ana oea na?ae/eei i?i iacaaa?oai?noue AN. Caoyaeiee ia?aa?a oai?iae a?aei?/aany o 18 oai?eo (43,9 %) ?c 41 iniae, ye? ?aaoey?ii ianoaaeoaaeenue i?ioyaii 3 - 4 i?nyoe?a i?ney aeienee ?o ?c noaoe?iia?o. Na?aae 26 oai?eo, ye? niinoa??aaeenue i?ioyaii 1 ?ieo, ?aoeeaeeae aeieeee o 8 in?a (30,8 %), c ieo o 3 aiie aoee ?aii?ie (o no?iee aei 3 i?n i?ney ia?aianaii? aino?i? oi?ie AN), o 2 - a?ae 3 aei 6 i?nyoe?a, o 3 a?aei?/aeenue i?ci? ?aoeeaeeae (a?ae 6 i?n aei 1 ?ieo). O oai?eo ia AN neiae?ii ?ioieneeaoe?? aoa neaai ae?aaeaiee. I?ioa a?io?i?/i? aeine?aeaeaiiy, cie?aia iaeiiai ?c iieaciee?a "iaoaaie?/ii? ?ioieneeaoe??", oiaoi ?ioieneeaoe??, yea a?aeia?aaea? ii?ooaiiy iai?io ?a/iaei ? noi?iaiaeaeo?oueny iaeiie/aiiyi i?e?iaeiuei ?nioth/eo, i?ii?aeieo ? e?ioeaaeo i?iaeoeo?a ?o iai?io, iaii?iaeueieo iaoaaie?o?a (E.E.A?iiaoaanueea, 1979) - eiioeaio?aoe?? "NI" o ne?iaaooe? e?ia? ? a na/?, ni?aa?aeiioaiiy i?ae ieie aeyaeei iaai? ?o ci?ie. Oae, o oai?eo ia AAN ia i?ioyc? o?ueio oeaei?a niinoa?aaeaiiy aecia/aeanue i?aeaeuaia eiioeaio?aoe?y "NI" o e?ia? ? a na/?: a e?ia? o 1/3 ianoaaeaieo (a?ae 0,74 a/e aei 1,0 a/e, i?e ii?i? 0,22 - 0,73 a/e, a na?aaeiueiio 0,59 a/e, a na/? - iaeaea o an?o (a?ae 9,1 a/e aei 18 a/e), o 1/3 - a iaaeao 16-19 a/e, o ie?aieo in?a iaa?oue a?eueoa, i?e ii?i? 9 a/e. Aiae?c aeoeaiino? AeAO a oe?euei?e ? ?icaaaeai?e ne?iaaoeao e?ia? o oai?eo ia AAN i?e iaaeoiaeaeaii? ?o aei noaoe?iia?o iieacaa (oaae 2), ui o ia?aaaaei?e a?eueoino? (iaeaea o 2/3) aeoeai?noue AeAO a oe?euei?e ne?iaaooe? e?ia? aecia/aeanue a iaaeao a?ae 1,2 aei 5,0 iiieue/ae, i?e oeueiio o 1/3 - aei 3,0 iiieue/ae. Iaea?eueo aeniea aeoeai?noue AeAO (14,1 ? aeua) niinoa??aaeanue eeoa o o?ueio ?c 66 ianoaaeaieo. O ?icaaaeai?e ne?iaaooe? e?ia? o 51,5 % oai?eo aecia/aeenue ii?iaeuei? iieacieee AeAO. O oeo in?a, o yeeo i?e ?icaaaeaii? ne?iaaoee e?ia? aeoeai?noue oeueiai oa?iaioo c?inoaea, e?aoi?noue i?aeaeuaiiy ("aoaeo ?icaaaeaiiy") aoea ??ciith. ?c 32 in?a c i?aeaeuaiiyi i?e ?icaaaeaii? ne?iaaoee e?ia?, o 62,5 % aiia c?inoaea aei 2 ?ac, o 37,5 % - a 2,1 - 5 ?ac?a. Oaaeeoey 2. ?iciiae?e oai?eo ia aino?ee aaiaoeo N ii iieacieeai aeoeaiino? AeAO a oe?euei?e ne?iaaooe? e?ia? i?e iaaeoiaeaeaii? aei noaoe?iia?o, aeienoe? oa o a?aeaeaeaiiio ia??iae? niinoa?aaeaiiy Aeoeai?noue AeAO, iiieue / aeOi?ie oyaeeino?Ianoa-aeaiiaei 1,01,2 - 3,03,1 - 5,05,1 - 8,08,1 - 11,011,1 - 14,014,0 ? a?eueoaI?e iaaeoiaeaeaii? aei noaoe?iia?oEaaea53picscalex100010009000003be0000000300170000000000050000 000902000000000400000002010100050000000102ffffff00040000002e011800050000 00310201000000050000000b0200000000050000000c02400480031200000026060f001a 00ffffffff000010000000c0ffffffb1ffffff40030000f10300000b00000026060f000c 004d617468547970650000e00009000000fa02000010000000000000002200040000002d 010000050000001402200240000500000013022002290317000000fb0240fe0000000000 009001000000cc0402001054696d6573204e657720526f6d616e2043797200cc7e040000 002d01010008000000320aad03450201000000380008000000320aad03f001010000002c 0008000000320aad03440002000000333508000000320a8d01be000200000031390a0000 0026060f000a00ffffffff01000000000010000000fb021400090000000000bc02000000 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I?e aeienoe? c noaoe?iia?o o 48,5 % oai?eo aeoeai?noue AeAO o oe?euei?e ne?iaaooe? e?ia? ciaoiaeeeanue a iaaeao ii?iaeueieo iieaciee?a, o 51,5 % aoea i?aeaeuaiith (o 45,5 % - iacia/ii i?aeaeuaia a?ae 1,2 aei 3,0 iiieue/ae, aea na?aae ieo o a?eueoino? - a?ae 1,2 aei 2,0 iiieue/ae, o 6,0 % - a?ae 3,1 aei 8,0 iiieue/ae). A ?icaaaeai?e ne?iaaooe? e?ia? o 12,1 % oai?eo niinoa??aaeinue i?aeaeuaiiy e?aoiino? ni?aa?aeiioaiiy i?ae iieacieeaie a ?icaaaeai?e ? oe?euei?e ne?iaaoeao, oiaoi "aoaeo ?icaaaeaiiy" aeyaeyany o iaaaeeei? e?eueeino? ianoaaeaieo. I?e niinoa?aaeaii? ca 33 oai?eie a aeeiai?oe? /a?ac 6 i?nyoe?a i?ney aeienee ?o ?c noaoe?iia?o, aeoeai?noue AeAO a oe?euei?e ne?iaaooe? e?ia? aoea ii?iaeueiith o 33,3 % ? i?aeaeuaiith o 66,7 % in?a. A ?icaaaeai?e ne?iaaooe? e?ia? o 63,6 % aoee ii?iaeuei? iieacieee, o 36,4 % - i?aeaeuai?. O 3 oai?eo aecia/aany "aoaeo ?icaaaeaiiy". *a?ac ??e ?c 26 oai?eo o 11 in?a aoee ii?iaeuei? iieacieee AeAO a oe?euei?e ne?iaaooe? e?ia?, o 15 - i?aeaeuai?. A ?icaaaeai?e ne?iaaooe? e?ia? o 9 in?a aeoeai?noue AeAO caeeoaeanue i?aeaeuaiith. "Aoaeo ?icaaaeaiiy" niinoa??aaany o 4 oai?eo. Oaeei /eiii, ? i?e aeienoe? c noaoe?iia?o, ? o a?aeaeaeaiiio ia??iae? - /a?ac 6 i?nyoe?a oa 1 ??e o /anoeie oai?eo ia AAN a?aei?/aeenue i?aeaeuai? iieacieee aeoeaiino? AeAO, o iaaaeeei? e?eueeino? c ieo aeyaeyany "aoaeo ?icaaaeaiiy". I?aaenoaaeyei ?ioa?an i?iaanoe aiae?c ee?i?/ieo aeaieo o oai?eo ia AAN ie?aii c i?aeaeuaieie oa ii?iaeueieie iieacieeaie aeoeaiino? AeAO i?e aeienoe? c noaoe?iia?o oa a oiae? iiaeaeueoeo niinoa?aaeaiue. I?e aeienoe? na?aae 34 oai?eo c i?aeaeuaieie iieacieeaie aeoeaiino? AeAO a oe?euei?e ne?iaaooe? e?ia? AAN niinoa??aaany o 12 in?a, ca?eueoaiiy ?ici???a ia/?iee aei 3 ni ieae/a e?ath ?aa?iai? aeoae - o 25, nieaiiiaaae?y - o 10 /ie; o oai?eo c ii?iaeueieie iieacieeaie: AAN - o 7 in?a, aaiaoiiaaae?y - 18, nieaiiiaaae?y - o 8 /ie. *a?ac 6 i?nyoe?a o oai?eo (22 /ie) c i?aeaeuaieie iieacieeaie AeAO AAN a?aei?/aany o 7, aaiaoiiaaae?y - 15, nieaiiiaaae?y - 6 in?a; c ii?iaeueieie iieacieeaie - o 3, 6, 2, a?aeiia?aeii. *a?ac 1 ??e o oai?eo (15 /ie) c i?aeaeuaieie iieacieeaie AeAO AAN aoa o 7, aaiaoiiaaae?y - o 11, nieaiiiaaae?y - 5; o in?a c ii?iaeueieie iieacieeaie: AAN - o 2, aaiaoiiaaae?y - o 5. Oaeei /eiii, o oai?eo ia AAN ? c i?aeaeuaieie, ? c ii?iaeueieie iieacieeaie aeoeaiino? AeAO niinoa??aaeenue aeaye? ee?i?/i? neiioiie, a naia: AAN, ca?eueoaiiy ?ici???a ia/?iee, iiaeeeaa nieaiiiaaae?y. O in?a c ii?iaeue-ieie iieacieeaie oe? ee?i?/i? neiioiie aeyaeyeenue aeaui ??aeoa, i?ae o oai?eo c i?aeaeuaiith aeoeai?noth AeAO. Oaea ea?oeia iiaea na?ae/eoe i?i iacaaa?oa-i?noue iaoieia?/iiai i?ioeano ia o?eueee o oai?eo c i?aeaeuaiith, aea ? c ii?iaeue-iith aeoeai?noth AeAO. Oe? iniae iio?aaothoue iiaeaeueoiai niinoa?aaeaiiy. I?e ianoaaeaii? oai?eo ia AN aoee aeyaeai? iniae c aaiaoeoii A+N. I?e aea/aii? ee?i?/ieo ? a?io?i?/ieo iieaciee?a o oeeo oai?eo, ia aeyaeaii niaoee-o?/ieo iniaeeainoae, oa?aeoa?ieo o?eueee aeey oe??? i?eno-?ioaeoe??. Nii-noa??aaeanue aeayea oaiaeaioe?y aei a?eueo oyaeeiai ia?aa?ao oai?iae. Caa?oathoue ia naaa oaaao a?eueo aeniea aeoeai?noue AeAO a oe?euei?e ne?iaaooe? e?ia? o cia/ii? e?eueeino? oai?eo ? aeaui aeu? iieacieee ni?aa?aeiioaiiy aeoeaiino? AeAO a ?icaaaeai?e ? oe?euei?e ne?iaaoeao e?ia? (e?aoi?noue ci?i, “aoaeo ?icaaaeaiiy”).I?iaiae?ciaai? ee?i?/i? oa eaai?aoi?i? iieacieee ia iiaeooue aooe aeei?enoai? ye e?eoa??? aeeoa?aioe?eiiai ae?aaiico aac iae?eo aeaieo ?OA c aeyaeaiiyi aioe-HCV, HNV-RNA, ia?ea??a AA. Eaoaeueiee iane?aeie a?aei?/aany o 3 in?a (4,7 %), c ieo o 1 oai?iai ia OeI, 2 - c oyaeeith oi?iith aaiaoeoo A+N; o 1 oai?iai niinoa??aaany ooeuei?iaioiee aaiaoeo. Na?aae oai?eo ia OAN o 27,4 % ae?aaiinoiaaia iai?oanoia, o 53,4 % - noaee?i?/ia, o 19,2 % - ?iaia?aioia oi?ie. I?ney aeieeiaiiy o?ii?/ia INV-?ioaeoe?y a 1/2 aeiaaeeao ia?aa?aaea eaoaioii aac yne?aai? ee?i?/ii? ea?oeie ? aeiaoyie/iiai neiae?iio. Na?aae ianoaaeaieo iaie oai?eo noaee?i?/ia oi?ia /ano?oa aeyaeyeanue o aeiii??a noaioe?? ia?aeeaaiiy e?ia? (o iaoiio niinoa?aaeaii? ia??iae aeiii?noaa o ieo neeaaeaa a?ae 1 aei 17 ?ie?a). Oea aoee oai?? iieiaeiai a?eo a?ae 18 aei 40 ?ie?a, a iniiaiiio /ieia?ee. Ca?a?no?iaaiee ii/aoie oai?iae c iacia/iiai i?aeaeuaiiy aeoeaiino? AeAO o iaaeao 1,2-2,4 iiieue/ae, iiaeaeueoee ?icaeoie ee?i?/ieo neiioii?a oai?iae i?ioiaeea c i?i?iaeueiith aeoeai?noth iaoieia?/iiai i?ioeano. Ia a?aei?io a?ae noaee?i?/ii? oi?ie, i?e ?iaia?aioi?e aeyaeyeenue aioe-HCV, aea ia a?aei?/aeinue i? a?io?i?/ieo, i? ee?i?/ieo iciae, ye? a aiai?eee i?i iayai?noue aaiaoeoo. Oaeo aeyaeaiiy aioe-HCV na?aae oeeo in?a ie ?icoe?ithaaee ye "caei?iaa" iin?enoai, aiaeia?/ia aneiioiiiiio iin?enoao HBsAg. Oi?ioaaiiy ee?i?/ii iai?oanoiiai OAN i?ioiaeeei i?ioyaii 1-10-19 ?ie?a. Onoaiiaeaii, ui o 60 % oai?eo ia OAN aoea aeyaeaia iaoieia?y oeoieiai-eeoeiaiai o?aeoo. O i?ia?anoaaii? iaoieia?/iiai i?ioeano aieiaio ?ieue a?ae?a?aaaee iiaoi?i?, a a aeayeeo aeiaaeeao aacia?a?ai? caaino?aiiy, a cia/i?e i??? iia’ycai?, i/aaeaeii, c ia?nenoaioe??th a??ono oa ?ioiieie iaoai?ciaie, ye? iaoiiaeththoue o?aaeaiiy oa caaeaaeue aaiaoioeeo?a. Na?aae 40 oai?eo ia iai?oanoio oi?io aacia?a?aia aeoeai?noue i?ioeano i?ney ia?aia-naiiai aino?iai ia??iaeo iaea i?noea o 27,5 % oai?eo, o 60 % in?a a?aei?/aeinue a?ae 1 aei 8 caaino?aiue c ??cieie ?ioa?aaeaie iaaeoeaiiai noaio ? a 10 % oai?eo ee?i?/ia ea?oeia aia?oa i?iyaeeanue iciaeaie noi?iiaaiiai OeI. O?ii?/ia HCV-?ioaeoe?y aecia/aeanue iaiaeiioeiia?noth o nai?o ee?i?/ieo i?iyaao. Ee?i?/i? aeai? a noaae?? caaino?aiiy oa?aeoa?ecoaaeenue caaaeueiith neaae?noth, cieaeaiiyi i?aoeacaeaoiino?, ioaeioith, aaaee?noth o i?aaiio i?ae?aaa?’?, iayai?noth aeno?aia/?ieiaeo ciae?a, aaiaoie??iaeueiiai neiae?iio (oaae 1). I?e OeI aeineoue /anoi a?aei?/aeanue o?eaaea ?eoa?e/i?noue neea? ? ??ci? i?iyae aaii?aa?/iiai neiae-?iio, iaa?yei-anoeeoe/iee neiae?ii. Ee?i?/ia ea?oeia OAN ia iaea niaoeeo?/-ieo ?en ii??aiyii c ?ioeie a??onieie aaiaoeoaie, iaeiae aeey HNV-?ioaeoe?? oa?aeoa?ia aeniea aeoeai?noue i?ioeano, eiai oee?iciaaiia iai?aaeai?noue. Ia??aeei a iaoieia?/iee i?ioean caeo/aeenue ?io? i?aaie ? nenoaie. Iaea?eueo /anoei ?c iicaia/?ieiaeo i?iya?a, cao?eniaaieo o iaoeo niinoa?aaeaiiyo, aoa noaeiaiee neiae?ii (12,5 %). Neiae?ii Oaa?aia, oe?ai?aeeo, iao?eo aoee a?aei?/ai? o 5 % in?a eiaeiee, a aaii?aa?/iee aaneoe?o ? aea?a?/iee aea?iaoeo cono??/aeenue o iiiaeeiieeo oai?eo. Iieacieee aeoeaiino? AeAO a oe?euei?e ? ?icaaaeai?e ne?iaaoeao e?ia? o oai?eo ia OAN iaaaaeai? a oaae 3. I?aaenoaaeai? aeai? iieacaee, ui o oai?eo ia OAN aecia/aeanue, a iniiaiiio, ii?iaeueia aai iii??ii i?aeaeuaia aeoeai?noue AeAO a oe?euei?e ne?iaaooe? e?ia?, aeniea aeyaeyeanue ??aeei. A ?icaaaeaieo ne?iaaoeao e?ia? i?aeaeuaiiy aeoeaiino? AeAO ia niinoa??aaeinue, oiaoi aoa a?aenooi?e "aoaeo ?icaaaeaiiy". Ii??aiyeueiee aiae?c aeaieo o oai?eo iai?oanoiith ? noaee?i?/iith oi?iaie OAN ia aeyaea nooo?aeo a?aei?iiinoae i?ae oeeie a?oiaie. O in?a c iai?oanoiith oi?iith cono??/aeenue a?eueo aenie? iieacieee, i?ae i?e noaee?i?/i?e oi?i?. I?ioa o eiaeiiai eiie?aoiiai oai?iai oe? a?aei?iiino? i?aeoe/iiai cia/aiiy ia iaee, oei a?eueoa, ui i?aeaeuai? iieacieee /ano?oa aeyaeyeenue ia caeiiii??ii. O ianoaaeaieo oai?eo ia OeI aeoeai?noue AeAO aoea a iaaeao ii?iaeueieo iieaciee?a. O in?a c OAN i?aeaeuaia eiioeaio?aoe?y "NI" a e?ia? aecia/aeanue o 3/4 ianoaaeaieo a iaaeao 0,74-2,0 a/e, a na/? iaae? eiioeaio?aoe?? "NI" aeae?eueea iaio?, i?ae i?e AAN. Ii??aiyiiy iieaciee?a "NI" o oai?eo ia OAN c iai?oanoiith ? noaee?i?/iith oi?iaie iieacaee, ui o in?a c iai?oanoiith oi?iith ? a ne?iaaooe? e?ia?, ? a na/? iaae? eiioeaio?aoe?? "NI" a?eueo aocuee? - o oai?eo c iai?oanoiith oi?iith aiia aoea a?eueo aenieith. O ianoaaeaieo oai?eo ia OeI caeaeae a?io?i?/ieo iieaciee?a oa?aeoa?ecoaaeenue oaeith ea?oeiith: i?aeaeuaiee ai?no "NI" o ne?iaaooe? e?ia? oa aeecueeee aei ii?ie a na/? a?aei?/aany a ia??iae ae?aaeaii? aeoeaaoe?? iaoieia?/iiai i?ioeano c neiae?iiii oeeoie?co ? c neiae?iiii oieanoaco. I?e noi?iiaaiiio OeI eaoaioiiai ia?aa?ao aecia/aeenue aenie? iieacieee "NI" o ne?iaaooe? e?ia? oa na/?. Oaeei /eiii, o oai?eo ia OAN, ia caaaeath/e ia a?aenooi?noue yne?aaeo ee?i?/ieo i?iya?a ?ioieneeaoe??, aeyaeai? a?io?i?/i? ci?ie, ye? na?ae/aoue i?i "ia-oaaie?/io ?ioieneeaoe?th", iieacieee yei? iiaeooue aeacoaaoe ia ia?aa?a oai?iae. Aea/aiiy iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo i?iaaaeaii o 84 oai?eo, na?aae yeeo o 21 iniae aoa ae?aaiinoiaaiee AAN, o 10 - aaiaoeo A+N, o 30 - OAN, o 23 - AAA. Aeai? ?ioiieia?/iiai aeine?aeaeaiiy o oai?eo ia AN aeyaeee nooo?a? ci?ie ?ioiieia?/iiai noaoono, aoi?eiio ?ioiieia?/io iaaeinoaoi?noue, yea oa?aeoa?ecoaaeanue cieaeaiiyi caaaeueieo A-?OE oa ci?iith iniiaieo ?aaoeyoi?ieo Aeoeai?noue AeAO a oe?euei?e oa ?icaaaeai?e ne?iaaoeao e?ia? o oai?eo ia o?ii?/iee aaiaoeo N Oi?ie OANNAeoeai?noue AeAO, iiieue/aeOe 0,11 - 0,220,35 - 0,50,6 - 0,70,71 - 0,80,9 - 1,51,6 - 2,94 - 89 ? aeuaAnueiaiIai?oanoia?0,14-0,150,04 - 0,140,03 - 0,040,02 - 0,150,04 - 0,150,04 - 2,20,02 - 4,80,02 - 9,0E?euee?noue oai?eopicscalex100010009000003ae0000000300170000000000050000000902000000 000400000002010100050000000102ffffff00040000002e011800050000003102010000 00050000000b0200000000050000000c02600400021200000026060f001a00ffffffff00 0010000000c0ffffffa8ffffffc0010000080400000b00000026060f000c004d61746854 7970650000e00009000000fa02000010000000000000002200040000002d010000050000 001402400240000500000013024002bf0117000000fb0240fe0000000000009001000000 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0000000000000000040000002d010600050000001402550bd60305000000020101000000 0500000013022006a903050000001402550bd603050000001302550bb103050000001402 b40ad103050000001302b40aac03050000001402110acb03050000001302110aa6030500 000014026d09c6030500000013026d09a103050000001402c708c003050000001302c708 9b030500000014021f08ba030500000013021f0895030500000014027707b50305000000 130277079003050000001402cc06af03050000001302cc068a030500000014022006a903 0500000013022006840309000000320a250b77030100000030c32e0009000000320a840a 72030100000035c32e000a000000320ae1093e030200000031302e002e000a000000320a 3d0939030200000031352e002e000a000000320a970833030200000032302e002e000a00 0000320aef072d030200000032352e002e000a000000320a470728030200000033302e00 2e000a000000320a9c0622030200000033352e002e000a000000320af0051c0302000000 34302e002e00040000002d010200040000002d010400040000002d010300040000002701 ffff030000001e00040000002d010200040000002d010600050000000102ffffff000500 00000902000000000700000016042409090361087f020500000004010d00000005000000 02010100000009000000320a7f0890020100000025306800040000002d01040004000000 2d010300040000002701ffff030000001e00040000002d010200040000002d0106000500 00000102ffffff0005000000090200000000070000001604960e2f0fc003780004000000 2d010400040000002d010300040000002701ffff030000001e00040000002d0102000400 00002d010600050000000102ffffff0005000000090200000000070000001604960e2f0f c0037800040000002d010400040000002d010300040000002701ffff030000001e000400 00002d010200040000002d010600050000000102ffffff00050000000902000000000700 00001604960e2f0fc0037800040000002d010400040000002d010300040000002701ffff 030000001e00040000002d010200040000002d010600050000000102ffffff0005000000 090200000000070000001604b70e500f00000000040000002d010700040000002d010a00 040000002d01040004000000f0010600040000002701ffff050000000c02180bf90e0300 00001e00050000000102ffffff0005000000090200000000040000002701ffff05000000 0b0200000000030000001e00050000000102ffffff000500000009020000000004000000 f00101002d000000f7000003140000000000800000000080000080800000000080008000 800000808000c0c0c000c0dcc000a6caf000fffbf000a0a0a40080808000ff00000000ff 0000ffff00000000ff00ff00ff0000ffff00ffffff000400000034020100040000002701 ffff03000000000000000000000000000000000000000000000000000000000000000000 00000000000000000000000000000000000000000000 ?en. 2. ?ioiieia?/i? iieacieee i?e ??cieo ee?i?/ieo oi?iao aaiaoeoo N. Ci?ithaaany ai?no eiio?iethth/iai eaioethaa O-ee?oei a a?e a?ia?noi?an?? (On - 20,6 ±3,1 %) i?e ciaioaii? O-oaeia??a iaeaea aaea?/? (11,5 ±1,5 %) /?<0,05/, ui i?ecaiaeeei aei ?aaa?n?? ni?aa?aeiioaiiy ?ioii?aaoeyoi?ieo noaiiioeyoe?e Oo/On, ciaioaiiy oeueiai iieacieea i?e oyaeeeo oi?iao aei 0,5. Ia?aaaaeia ca?eueoaiiy O-noi?ani??a i?e iaeii/aniiio ciaioaii? O-oaeia??a ni?eyei i?eai?/aiith ?ioiieo ?aaeoe?e, ye? iai?aaeai? ia aethi?iaoe?th a??ono, caoyaeiiio, o?ii?/iiio ia?aa?ao iaoieia?/iiai i?ioeano. Nooi?iue ae?aaeaiino? oeeo ci?i caeaaeaea a?ae oyaeeino? oa iane?aee?a aaiaoeoo. Noiniaii ci?ie iieaciee?a aoii?aeueii? eaiee ?ioi?oaoo, oi i?aeaeuaiiy ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) i?e ??cieo nooiaiyo oyaeeino?, eiioeaio?aoe?? ?gI ? IgG na?ae/eee, ia iao iiaeyae, i?i aeoeaaoe?th aoii?aeueiiai ?ioi?oaoo. I?e aaiaoeo? A+N a?aei?/aeinue a?eueo ae?aaeaia i?eai?/aiiy e?euee?nieo iieaciee?a ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo, yea, i/aaeaeii, iia’ycaia c iayai?noth cia/iiai a?aenioeo ?i’?eoe?eieo ia?eiiai?a (42,4 %), ui ne?ae ?icaeyaeaoe ye oaeoi?, yeee ni?ey? ?ioiieia?/iei ii?ooaiiyi. O oai?eo ia OAN oaeiae a?aei?/aia ?ioiinoi?an?y ii O-ee?oeiiiio oeio. Niinoa??aaeinue i?iaeiaaeaia ia?nenooaaiiy Oe?E, ui na?ae/eei i?i ?icaeoie iia?eueii? ?ioaeoe?? oeyoii oi?ioaaiiy Oe?E, a?aeeeaaeaiiy yeeo ia aaiaoioeeoao coiiaeth? ?icaeoie iia?eueii i?ia?anoth/i? caiaeueii? ?aaeoe??. Oaeei /eiii, i?iaaaeai? aeine?aeaeaiiy iieacaee, ui AN caeia? nooo?aa i?noea a ?ioaeoe?ei?e iaoieia?? ethaeeie. Io?eiai? aeai? i?i ee?i?ei-ai?aeai?ieia?/i? iniaeeaino? AN iiaeooue ?icaeyaeaoenue ye iaiao?aeia ia?aaeoiiaa aeey ?ic?iaee iaoeiai-iaa?oioiaaieo iaoiae?a e?eoaaiiy oa nenoaie i?io?eaeoeee oe??? ?ioaeoe??. AENIIAEE 1. Ieoiia aaaa iiiiao?ieia?/iiai aaiaoeoo N na?aae oai?eo ia a??oni? aaiaoeoe, aini?oae?ciaaieo o EIAe?A?O, neeaea 18,5 %. Aieiaieie oaeoi?aie, ui ni?eyee ?io?eoaaiith oai?eo a??onii aaiaoeoo N, aoee e?eoaaeueii-ae?aaiinoe/i? iaaee/i? ao?o/aiiy (49,4 %), aioo??oiueiaaiia aaaaeaiiy ia?eioe/ieo ?a/iaei (32,7 %). O 17,9 % oai?eo eiie?aoi? oeyoe ?io?eoaaiiy ia onoaiiaeai?. 2. Aino?ee aaiaoeo N oa?aeoa?ecoaaany iie?ii?o?ciii ee?i?/ieo i?iya?a, o a?eueoino? oai?eo ia?aa?aaa o aacaeiaoyie/i?e (21,6 %) ? eaae?e aeiaoyie/i?e (59,5 %) oi?iao, iaa aenieo /anoioo caoyaeiiai ia?aa?ao (43,9 %), ?aoeeaeea?a (30,8 %), iacaaa?oaiino? iaoieia?/iiai i?ioeano (57,7 %). 3. O?ii?/iee aaiaoeo N aeyaeyany a iai?oanoi?e (27,4 %), noaee?i?/i?e (53,4 %) oa ?iaia?aioi?e (19,2 %) oi?iao, ?icaeaaany /ano?oa eaoaioii, ia iaa ae?aaeaii? ee?i?/ii? neiioiiaoeee, oa?aeoa?ecoaaany aaiaoiiaaae??th, yea /anoi noi?iaiaeaeoaaeanue nieaiiiaaae??th, iayai?noth aeno?aia/?ieiaeo ciae?a oa iicaia/?ieiaeie i?iyaaie, ci?iaie aoino?oeoo?e ia/?iee. 4. O oai?eo ia iai?oanoio oi?io o?ii?/iiai aaiaoeoo N a?aei?/aeanue ia?aaaaa ia??iae?a caaino?aiue iaae ?ai?n?yie, o 25 % c ieo aoa ae?aaiinoiaaiee oee?ic ia/?iee. I?e oee?ic? ia/?iee ia??aeei niinoa??aaeanue o?eaaea ?eoa?e/i?noue neea? ? ??ci? i?iyae aaii?aa?/iiai oa iaa?yei-anoeeoe/iiai neiae?ii?a, aeeni?ioa?iai?y c aenieei ??aiai aaiaaeiaoe?i?a. 5. O 2/3 oai?eo ia aino?ee aaiaoeo N aecia/aeinue iacia/ia (1,2 - 3,0 iiieue/ae) aai iii??ia (3,0 - 5,0 iiieue/ae) i?aeaeuaiiy aeoeaiino? AeAO o oe?euei?e ne?iaaooe? e?ia?. I?e aeienoe? c noaoe?iia?o o 48,5 % aoee ii?iaeuei? ? o 51,5 % iacia/ii aai iii??ii i?aeaeuai? iieacieee. Oaea iai?aaeai?noue ni?aa?aeiioaiiy onoaiiaeaia ? /a?ac 6 i?nyoe?a oa 1 ??e niinoa?aaeaiiy. Caeiiii??iiai ca’yceo i?ae iieacieeaie aeoeaiino? AeAO a oe?euei?e ? ?icaaaeai?e ne?iaaoeao e?ia? ia aeyaeaii. I?e o?ii?/iiio aaiaoeo? N o 3/4 ianoaaeaieo oai?eo aecia/aeenue ii?iaeuei? iieacieee aeoeaiino? AeAO. O /anoeie oai?eo ii?iaeuei? iieacieee ia?aiaaeiaoaaeenue c i?aeaeuaieie. "Aoaeo ?icaaaeaiiy" aoa a?aenooi?i. Eiioeaio?aoe?y "NI" a e?ia? aoea i?aeaeuaia o 1/3 oai?eo ia aino?ee aaiaoeo N oa o 3/4 - ia o?ii?/iee aaiaoeo N. 6. O oai?eo ia aino?ee aaiaoeo N i?e aeienoe? ?o ?c noaoe?iia?o oa o a?aeaeaeai? no?iee (6 i?n, 1 ??e) iiaee niinoa??aaoenue: anoaii-aaaaoaoeaiee neiae?ii, aaiaoiiaaae?y, nieaiiiaaae?y. Oeacai? ee?i?/i? neiioiie aecia/aeenue o in?a ? c i?aeaeuaieie, ? c ii?iaeueieie iieacieeaie AeAO, aea i?e ii?iaeueieo iieacieeao oe? ee?i?/i? neiioiie aeyaeyeenue aeaui ??aeoa, i?ae i?e i?aeaeuai?e aeoeaiino? AeAO. I?e iayaiino? ee?i?/ieo i?iya?a iniae ? c i?aeaeuaiith, ? c ii?iaeueiith aeoeai?noth AeAO iio?aaothoue iiaeaeueoiai niinoa?aaeaiiy, ye ? oai?? o?eueee c i?aeaeuaiith aeoeai?noth AeAO. 7. I?e aino?iio ? o?ii?/iiio aaiaoeo? N aeyaeaia aoi?eiia ?ioiieia?/ia iaaeinoaoi?noue ii O-ee?oeiiiio oeio, ui i?iyaeyeanue cieaeaiiyi caaaeueieo A-?OE oa ci?iith iniiaieo ?aaoeyoi?ieo eaioetha?a O-nenoaie ?ioi?oaoo a a?e a?ia?noi?an??. ?acii c oei, aeyaeai? i?aeaeuaiiy ??aiy Oe?E, ca?eueoaiiy eiioeaio?aoe?? ?gI ? ?gG. IA?AE?E ?IA?O, UI IIOAE?EIAAI? CA OAIITH AeENA?OAOe?? 1. Ee?i?/ia oa ?ioiieia?/ia oa?aeoa?enoeea a??oniiai aaiaoeoo N //AEo?iae i?aeoe/aneiai a?a/a. - 1998. - ?3. - N. 38-39 (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A., Aia?iaith ?.A. oa ?i.). 2. Iniaaiiinoe aeioeie/aneeo enneaaeiaaiee i?e o?iie/aneii aaiaoeoa N //AEo?iae i?aeoe/aneiai a?a/a. - 1998. - ?6. - N. 11-14 (a niaao. n A?iiaoaaneie E.E., Oaoueyiei I.A., Ao?aeai A.E. e ae?.). 3. Iaoiae i?eiaiaiey ?aeiiaeiaioiiai eioa?oa?iia aeueoa - 2a (Eio?iia A) i?e o?iie/aneii ae?oniii aaiaoeoa N //Eioi?iaoeeiiiia ienueii ? 18-98 i iiaiaaaaeaieyo a nenoaia cae?aaiio?aiaiey. Aui. 2. - Eeaa. - 1998. (a niaao. n Aiae A.Ae., Eyoie I.A., Aioiiaiei N.A. e ae?.). 4. Ee?i?/ia oa ai?aeai?ieia?/ia oa?aeoa?enoeea a??oniiai aaiaoeoo "N" // Na. iao/i. o?. iaaeaeoia?iaeiie iao/ii-i?aeoe/aneie eiioa?aioeee "Nia?aiaiiua aniaeou aiaiiie iaaeeoeeiu". - Eeaa, 1998. - N. 249-250. 5. Eeeie/aneia oa/aiea HCV/HBV ieeno-aaiaoeoia // Na. iao/i. o?. iaaeaeoia?iaeiie iao/ii-i?aeoe/aneie eiioa?aioeee "Nia?aiaiiua aniaeou aiaiiie iaaeeoeeiu". - Eeaa, 1998. - N. 345-346. (a niaao. n Aiae A.Ae., Oaoueyiei I.A.). 6. "Eio?ii A" a ea/aiee aieueiuo ae?oniuie aaiaoeoaie // Na. iao/. o?. iaaeaeoia?iaeiie iao/ii-i?aeoe/aneie eiioa?aioeee "Nia?aiaiiua aniaeou aiaiiie iaaeeoeeiu". - Eeaa, 1998. - N. 141-142. (a niaao. n Aiae A.Ae., Oaoueyiei I.A., Eyoie I.A.). 7. Aei ieoaiiy i?i a??oniee aaiaoeo "N". // Iaoa??aee O??? c’?caeo Oe?a?inueeiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a oa ia?aceoieia?a ?i. Ae.E.Caaieioiiai. A?iieoey. - 1996. - N. 155-156 (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A., Oaa?iyi A.?.). 8. Eeeie/aneea iniaaiiinoe ae?oniiai aaiaoeoa N // THaeeaeiay iao/iay eiioa?aioeey "Eioaeoieiaey. Aeinoeaeaiey e ia?niaeoeau". - N.-Ia, 1996. - N. 55. (a niaao. n Aiae A.Ae., Oaoueyiei I.A., Oaaeiyi A.?.). 9. Aeaye? ai?aeai?ieia?/i? oa ee?i?/i? iniaeeaino? aaiaoeoo N // ?ioaeoe?ei? oai?iae: Ca. iaoe. i?. Aei. V. - Euea?a: "Aneoeai", 1997.-N. 19-20. 10. Aeeoa?aioe?eia ae?aaiinoeea a??onieo aaiaoeo?a N ? A // Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? "Iiaa a ae?aaiinoeoe? oa e?eoaaii? a??onieo oai?ia".- Noie, 1997.- N. 38-39. (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A.). 11. Aeooaeuei? ieoaiiy aaiaoeoo N // Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? “A?eia? iniaeeaino? ?ioaeoe?eieo oai?ia”. - Oa?iii?eue, 1998. - N. 24-25. (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A.). 12. Ee?i?ei-?ioiieia?/ia oa?aeoa?enoeea aaiaoeoo N // Iaoa??aee V c’?caeo ?ioaeoe?ii?no?a Oe?a?ie. – Oa?iii?eue, 1998. - N. 26-28. (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A., Aia?iaith ?.A. oa ?i.). 13. Aeanyoe??/iee aeina?ae canoinoaaiiy ?aeiia?iaioieo aaiii?iaeaia?ieo aeueoa - ?ioa?oa?ii?a i?e a??onieo aaiaoeoao // Iaoa??aee V c’?caeo ?ioaeoe?ii?no?a Oe?a?ie. - Oa?iii?eue, 1998. - N. 28-30. (o ni?aaao. c Aiae A.Ae., Oaoueyiei I.A., Oaaei?/aiei N.A. oa ?i.). 14. AIIOAOe?? Eeeiaiei AE.A. Eeeieei-yieaeaieieiae/aneea iniaaiiinoe aaiaoeoa N. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.13 - eioaeoeeiiiua aieacie. - Eeaaneee IEE yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei. E.A. A?iiaoaaneiai, Eeaa, 1999. A aeenna?oaoeee eceiaeaiu ?acoeueoaou yieaeaieieiae/aneeo, eeeieei-eaai?aoi?iuo enneaaeiaaiee 284 aieueiuo AN. Iaaethaeaiey i?iaiaeeeenue a aeeiaieea: i?e IAN - a oa/aiea aiaea, i?e OAN - aieaa 3-o eao. Yieaeaieieiae/aneee aiaeec iieacae, /oi iaeaieueoaa cia/aiea a eioeoee?iaaiee INV eiaee ea/aaii-aeeaaiinoe/aneea ia?aioa?aeueiua iaieioeyoeee (aaiio?ainoocee, eiuaeoeee eaea?noaaiiuo e aeeaaiinoe/aneeo i?aia?aoia, iia?aoeaiua aiaoaoaeuenoaa, ea/aiea o noiiaoieiaa, aeiaeieiae/aneea ianeaaeiaaiey) e aioo?eaaiiia aaaaeaiea ia?eioe/aneeo aauanoa. I?e IAN ioia/ai iieeii?oeci eeeie/aneeo i?iyaeaiee, iinoaiaiiia ia/aei, ionoonoaea /aoeie neiae?iiaeueiie oa?aeoa?enoeee i?aaeaeaeoooiiai ia-?eiaea n i?aiaeaaeaieai anoaii-aaaaoaoeaiuo yaeaiee e niaoaiiie neiioiia-oeee, neaai au?aaeaiiue eioieneeaoeeiiiue neiae?ii. O 81,1 % aieueiuo aeeaaiinoe?iaaiu eaaeay e aacaeaeoooiay oi?iu. O 43,9 % iaoeeaioia eiaee ianoi caoyaeiia oa/aiea, o 30,8 % - ?aoeeaeeau, o 57,7 % - iacaaa?oaiiinoue iaoieiae/aneiai i?ioeanna. O 2/3 aieueiuo IAN ii?aaeaeyeinue iacia/eoaeueiia eee oia?aiiia iiauoaiea aeoeaiinoe AeAO a oeaeueiie nuai?ioea e?iae. Caeiiiia?iiai niioiioaiey iaaeaeo iieacaoaeyie aeoeaiinoe AeAO a oeaeueiie e ?acaaaeaiiie nuai?ioeao e?iae ia onoaiiaeaii. O /anoe aieueiuo IAN /a?ac aiae auyaeyeenue iaeioi?ua eeeie/aneea neiioiiu: AAN, aaiaoiiaaaeey, nieaiiiaaaeey e i?e ii?iaeueiie e i?e iiauoaiiie aeoeaiinoe AeAO eee oieueei iiauoaiiay aeoeaiinoue AeAO. Yoi naeaeaoaeuenoaiaaei i iacaaa?oaiiinoe iaoieiae/aneiai i?ioeanna ia oieueei o aieueiuo n iiauoaiiie, ii e n ii?iaeueiie aeoeaiinoueth AeAO. Iie ioaeaeathony a aeaeueiaeoai iaaethaeaiee. O 1/3 aieueiuo auea iiauoaia eiioeaio?aoeey “NI” a e?iae. I?e ianeaaeiaaiee aieueiuo n aaiaoeoii A+N ioia/aeanue iaeioi?ay oaiaeaioeey e aieaa oyaeaeiio oa/aieth aieacie. O cia/eoaeueiie /anoe aieueiuo ii?aaeaeyeanue aieaa aunieay aeoeaiinoue AeAO a oeaeueiie nuai?ioea e?iae e ianeieueei iiauoaiiua iieacaoaee niioiioaiey aeoeaiinoe AeAO a ?acaaaeaiiie e oeaeueiie nuai?ioeao. OAN oa?aeoa?eciaaeny eaoaioiui oa/aieai, aaiaoiiaaaeeae, nieaiiiaaaeeae, iaee/eai yeno?aia/aii/iuo ciaeia, aiaia/aii/iuie i?iyaeaieyie, eciaiaieai yoino?oeoo?u ia/aie. Auaeaeaiu iaieoanoiay, noaeeeie/aneay e eiaiia?aioiay oi?iu. I?e OeI iaaethaeaeanue aeeeoaeueiay eeoa?e/iinoue neea? e ?aciua i?iyaeaiey aaii??aae/aneiai e ioa/ii-anoeeoe/aneiai neiae?iiia, aeeni?ioaeiaiey n aunieei o?iaiai aaiiaaei-aoeeiia. Ioia/aeanue oia?aiii iiauoaiiay e ii?iaeueiay aeoeaiinoue AeAO a oeaeueiie nuai?ioea e?iae, ionoonoaea “yooaeoa ?acaaaeaiey”, iaee/ea “iaoaaiee/aneie eioieneeaoeee”, eioi?ay i?iyaeyeanue iiauoaieai eiioeaio?a-oeee “CM” a e?iae e eciaiaieai eo niioiioaiey e?iaue/ii/a. Aeaiiua eiioiieiae/aneiai enneaaeiaaiey o aieueiuo AN auyaeee ii?a-aeaeaiiua eciaiaiey eiioiieiae/aneiai noaoona, aoi?e/ioth eiioiieiae/aneoth iaaeinoaoi/iinoue, eioi?ay oa?aeoa?eciaaeanue nieaeaieai iaueo A-?IE e eciaiaieai iniiaiuo ?aaoeyoi?iuo oeaiae O-nenoaiu eiioieoaoa. Eciaiyeny ninoaa eiio?iee?othuae oeaie O-eeaoie a noi?iio aeia?noi?annee i?e oiaiueoaiee O-oaeia?ia ii/oe a aeaa ?aca. Yoi i?eaiaeeei e ?aaa?nee niioiioaiey eiioii?aaoeyoi?iuo noaiiioeyoeee Oo/On, oiaiueoaiea yoiai iieacaoaey i?e oyaeaeuo oi?iao aei 0,5. Oaaee/aiea O-noi?anni?ia i?e iaeiia?aiaiiii oiaiueoaiee O-oaeia?ia niinianoaiaaei oaiaoaieth eiioiiuo ?aaeoeee, eioi?ua iai?aaeaiu ia yethieiaoeeth ae?ona, caoyaeiiio, o?iie/aneiio oa/aieth iaoieiae/aneiai i?ioeanna. Ia aeoeaaoeee aoii?aeueiiai eiioieoaoa naeaeaoaeuenoaiaaee iiauoaiea o?iaiy OeEE i?e ?aciuo noaiaiyo oyaeanoe, eiioeaio?aoeee IgM e IgG. O aieueiuo OAN oaeaea ioia/aia eiioiinoi?anney ii O-eeaoi/iiio oeio, aeeeoaeueiia ia?nenoe?iaaiea OeEE. Eeth/aaua neiaa: aaiaoeo N, yieaeaieieiae/aneea enneaaeiaaiey, eeeie/aneea i?iyaeaiey, o?iie/aneee aaiaoeo N, aeoeaiinoue AeAO. Eeeiaiei AE.A. Ee?i?ei-ai?aeai?ieia?/i? iniaeeaino? aaiaoeoo N. - ?oeiien Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.13 - ?ioaeoe?ei? oai?iae. - Ee?anueeee IAe? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai, Ee?a, 1999. A aeena?oaoe?? aeeeaaeai? ?acoeueoaoe ai?aeai?ieia?/ieo, ee?i?ei-eaai?aoi?ieo aeine?aeaeaiue 284 oai?eo ia AN. Niinoa?aaeaiiy i?iaiaeeeenue a aeeiai?oe?: i?e AAN - i?ioyaii ?ieo, i?e OAN - a?eueoa 3 ?ie?a. Iaea?eueoa cia/aiiy a ?io?eoaaii? INV iaee e?eoaaeueii-ae?aaiinoe/i? ia?aioa?aeuei? iai?ioeyoe?? oa aioo??oiueiaaiia aaaaeaiiy ia?eioe/ieo ?a/iaei. I?e AAN a?aei?/aiee iie?ii?o?ci ee?i?/ieo i?iya?a, o 81,1 % - eaaea ? aacaeiaoyie/ia oi?ie, ?aoeeaeeae, caoyaeiee ia?aa?a. O /anoeie oai?eo AAN /a?ac ??e aeyaeyeenue aeaye? ee?i?/i? neiioiie ? i?e ii?iaeuei?e, ? i?e i?aeaeuai?e aeoeaiino? AeAO aai o?eueee i?aeaeuaia aeoeai?noue AeAO. OAN oa?aeoa?ecoaaany eaoaioiei ia?aa?aii, iii??ii i?aeaeuaiith ? ii?iaeueiith aeoeai?noth AeAO, a?aenooi?noth “aoaeoo ?icaaaeaiiy”, i?aeaeuaiiyi eiioeaio?aoe?? “NI” o e?ia?. O oai?eo ia AN aeyaeaia ?ioiia iaaeinoaoi?noue ii O-ee?oeiiiio oeio. Eeth/ia? neiaa: aaiaoeo N, ai?aeai?ieia?/i? aeine?aeaeaiiy, ee?i?/i? i?iyae, o?ii?/iee aaiaoeo N, aeoeai?noue AeAO. Z.B. Klymenko. Nlinical and apidemiological peculiarities of hepatitis C. -Manuscript. Thesis for candidate's degree by specialty 14.01.13 - infectious diseases. Kyiv Scientific and Research Institute of Epidemiology and Infectious Diseases named after L.V. Gromashevsky, Kyiv, 1999. The dissertation shows the results of epidemiological, clinical, and laboratory research of 284 patients with Hepatitis C. The research was done in dynamics: under acute hepatitis C - within I year; under chronic hepatitis C -within more than 3 years. Medical-diagnostic parental manipulations and intravenous use of drugs had the biggest effect in infecting by HCV. Under acute hepatitis C, polymorphism of clinical demonstration has been detected, 81,1 % of patients showed light and non-jaundice forms, recurrence, and lingering course. After a year, a part of patients showed some clinical symptoms both under normal and increased activity of ALT, or just increased activity of ALT. Chronic hepatitis C was characterized by latent course, moderately increased and normal activity of ALT, absence of "dilute effect", increased concentration of "average molecules " in blood. Immunity deficit by T-cells type has been detected in hepatitis C patients. Key words: hepatitis C, epidemiological research, clinical demonstration, chronic hepatitis C, activity of ALT.

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