?inoeooo iaae?ao???, aeooa?noaa ? a?iaeieia??

Aeaaeai?? iaaee/ieo iaoe Oe?a?ie

Ua?aaothe Iaoae?y TH???aia

OAeE 616.155.194.8–085–053.2

Ee?i?/i? oa ia?aee?i?/i? i?iyae

cae?ciaeao?oeeoii? aiai?? o ae?oae

? iaoiaee ?o ei?aeoe??

14.01.10 – iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999 Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai IIC Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio AII Oe?a?ie

Ni?yi ?aai Naiaiiae/,

Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss.Ai?aa/aanueeiai
IIC Oe?a?ie,

caa?aeoaa/ eaoaae?e aeeoy/eo oai?ia e?eoaaeueiiai oaeoeueoaoo

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?

Ioo Aaeaioeia Aeieo??aia,

?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie,

ea??aiee a?aeae?eaiiy o?c?ieia?? ? iaoieia?? ae?oae ?aiiueiai a?eo;

aeieoi? iaaee/ieo iaoe, i?ioani?

Aaaaoei Aieiaeeie? A?eai?iae/,

aee?aeoi? ?inoeoooo ee?i?/ii? ?aae?ieia?? IOe?I AII Oe?a?ie

I?ia?aeia onoaiiaa:

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC
Oe?a?ie, i. Ee?a, eaoaae?a iaae?ao??? ?1

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 26 ” aeiaoiy  1999  ?ieo i 13
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee (Ae 26.553.01) ii
caoenoo aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai ? a?iaeieia?y” i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a,
aoe. Iaio?euenueeiai, 8)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
iaae?ao???, aeooa?noaa ? a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a,
aoe. Iaio?euenueeiai, 8)

Aaoi?aoa?ao ?ic?neaiee “ 29 ” /a?aiy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Eaaoi?ia E.A.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue i?iaeaie. Cae?ciaeao?oeeoia aiai?y (CAeA) ? iaei??th c
iaea?eueo iioe?aieo oi?i CAeA, yea ?a?no?o?oueny o 20% ianaeaiiy ieaiaoe
(AIIC, 1991). Na?aae ae?oae aeao?oeeo cae?ca (AeC) ? iia’ycaia c iei
aiai?y cono??/athoueny a e?a?iao c aenieei aeiiii?/iei ??aiai o 7-12% ?
a?ey 50% – o iaei?icaeiaieo ?aa?iiao (Pyne Kirk, S.Munsey, M.D.Wheby,
1996). *anoioa CAeA o ae?oae e?a?i NIAe eieeaa?oueny a iaaeao 10-70%
(E.A.Aeiaeaai, A.E.Aenaeueiee, 1998), a na?aae aini?oae?ciaaieo aei
noaoe?iia?o oey iaoieia?y ae?aaiinoo?oueny a 52-62% (E.I.Eacaeiaa,
1997). Caoai?thaai?noue ia CAeA ii Oa?iii?euenuee?e iaeano? ia?
oaiaeaioe?th aei ?inoo ? neeaaeaea a 1997?. 98.5 ia 1000 aeeoy/iai
ianaeaiiy. sseui acyoe aei oaaae, ui eaoaioiee AeC cono??/a?oueny a
2-2.5 ?ace /ano?oa CAeA, oi iioe?ai?noue neaea?iiai?? ? eaoano?io?/ii
aenieith (E.N.Eaaeiaei, I.E.Iao?aaaiei, I.E.Noa?iaieoia, 1996).

Ae?oe aoaeue-yeiai a?eo noeeuei? aei ?icaeoeo CAeA caaaeyee ?yaeo
ia?aaeoiia, na?aae yeeo i?ia?aeia cia/aiiy iathoue iniaeeaino?
noaiiaeaiiy ooieoe?? a?eo?ioeeoa?ii? nenoaie, iai?i cae?ca oa oaiie
?inoo (I.I.Iaaeiaa, 1996, M.Karr, G.Alperstein, J.Causer, 1996).
Iae/ano?oa AeC aeieea? a ia?o? aeaa ?iee aeeooy (o 40-50% ae?oae) ?
ia??iaee o?c?ieia?/iiai aeoyaaiiy, eiee CAeA aeyaey?oueny o 1/3-1/4
ianoaaeaieo (N.A.Aethea?aaa, 1995). Inoaii?i /anii niinoa??aa?oueny
cia/ia ca?eueoaiiy CAeA na?aae ae?oae aeioe?eueiiai ? oe?eueiiai a?eo,
ui a iaai?e i??? coiiaeaii nioe?aeueieie e aeieia?/ieie iaaa?acaeaie
(A.A.Aaaaoei, 1994).

Oai?aoe/ia ? i?aeoe/ia cia/aiiy eiea i?iaeai, iia’ycaieo ?c CAeA,
aecia/a?oueny ia o?eueee ?? cia/iith iioe?ai?noth, aea ? oeie
iaaaoeaieie aieeaaie, ye? ni?e/eith? AeC ia ??ci? nenoaie oa ooieoe??
i?aai?cio. Ee?i?/i? niinoa?aaeaiiy e aenia?eiaioaeuei? ?iaioe
iieacothoue, ui AeC i?aeaeuo? noeeuei?noue ae?oae aei ?ioaeoe?eieo
caoai?thaaiue (E.I.Eacaeiaa, E.I.Iae?ooei, 1992, O.C.Ia?/aiei, 1983),
ni?ey? oi?ioaaiith o?ii?/ieo aiaieu ?ioaeoe??, aaeueio? o?ce/iee ?
ia?aiai-ineo?/iee ?icaeoie, cieaeo? iiaeeea?noue ?icoiiai? ae?yeueiino?,
ciaioo? oiea?aioi?noue aei o?ce/ieo iaaaioaaeaiue, aaaea aei iiyae
aeaaaia?aoeaii-aeeno?io?/ieo i?ioean?a o o?aaiiio eaiae? oa i’ycia?e
nenoai? (E.I.?aoaoe?ia, N.A.Aaethe, 1991).

Iayaia o?aaeeoe?eia e?eoaaiiy oai?eo ia CAeA ? iaaeinoaoiuei aoaeoeaiei
? iaoyaeeeaei aeey aeeoeie. Aeiaaio?eaae? eo?ne oa?ioa?ai?? iiaeooue
aeaaaoe iaaaoeai? iia?/i? ?aaeoe?? (ss.A.Oi?ooia, 1998, C.Montecuclo,
R.Caparali, R.Invenuzzi, 1995), a iecueeee e?eoaaeueiee aoaeo ia??aeei
coiiaeaiee a?aenooi?noth eiiieaeniiai i?aeoiaeo aei ?aaa?e?oaoe??. Oiio
iiooe iiaeo iaoiae?a oa?ai?? aai oaeeo, ui iineeththoue aoaeo
o?aaeeoe?eiiai e?eoaaiiy, ? aeooaeueiei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, oaiaie.

Aeaia ?iaioa ? o?aaiaioii ieaiiai? oaie eaoaae?e aeeoy/eo oai?ia
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai “Aiaeiaaiia ?ioieneeaoe?y o ae?oae ?c ??ciith
iaoieia??th oa ?? aieea ia iaoiaaiaoe/i? iaoai?cie ? ee?i?/i? i?iyae
caoai?thaaiue”, ? aea?aeaaii? ?a?no?aoe?? – 0196V023277.

Iaoa ?iaioe: aaeineiiaeeoe iaoiaaiaoe/io oa?ai?th cae?ciaeao?oeeoieo
aiai?e o ae?oae oeyoii aeei?enoaiiy /a?acoe??iiai iaai?oieaca?iiai
ii?ii?iaiiy e?ia? (*IEIE) oa a?oai?io A.

Caaea/? aeine?aeaeaiiy.

Aea/eoe iniaeeaino? ee?i?/ieo i?iya?a, iieaciee?a ?ioi?oaoo, ia?aeeniiai
ieeneaiiy e?i?ae?a (IIE), aiaeiaaiii? ?ioieneeaoe?? (A?) o ae?oae,
oai?eo ia CAeA, o caeaaeiino? a?ae a?eo, nooiaiy oyaeeino?, o?eaaeino?
caoai?thaaiiy oa oiiiai? iaoieia??.

?ic?iaeoe e?eoa??? ae?aaiinoeee neiae?iio aiaeiaaiii? ?ioieneeaoe??
(NA?) o ae?oae, oai?eo ia CAeA.

Aecia/eoe iniaeeaino? aieeao o?aaeeoe?eii? oa?ai?? ia ee?i?/i? i?iyae,
noai ?ioi?oaoo, IIE, A? o oai?eo ae?oae.

Aeine?aeeoe aoaeoeai?noue ? iniaeeaino? aieeao ia ee?i?/iee ia?aa?a
CAeA, iieacieee ?ioi?oaoo, IIE, A? o?aaeeoe?eii? oa?ai?? CAeA oa i?e ??
ii?aeiaii? c *IEIE ? a?oai?iii A; a oaeiae ii??aiyoe aeeiai?eo
aeuaaeacaieo iieaciee?a i?ae a?oiaie ae?oae, ye? io?eioaaee o?aaeeoe?eia
? eiiieaenia e?eoaaiiy CAeA.

?ic?iaeoe i?aeoe/i? ?aeiiaiaeaoe?? uiaei canoinoaaiiy *IEIE ? a?oai?io A
a eiiieaeniiio e?eoaaii? oai?eo ia CAeA ae?oae.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aia?oa ia iniia? ee?i?ei-eaai?aoi?iiai ianoaaeaiiy c aeei?enoaiiyi
iieaciee?a ?ioi?oaoo, IIE, A? iaoiaaiaoe/ii iaa?oioiaaii o ae?oae,
oai?eo ia CAeA na?aaeiueiai oa oyaeeiai nooiai?a, ?icaeoie neiae?iio
aiaeiaaiii? ?ioieneeaoe?? ? iieacaii eiai aieea ia ?icaeoie CAeA.

Aeiaaaeaia iiaeeea?noue iaiaaeeeaiaioicii? ?aaoeyoe?? iaoaaie?/ieo
ii?ooaiue (aeoeaiino? IIE, ??aiy A?), ?ioiiiai noaoono oeyoii
canoinoaaiiy *IEIE ? a?oai?io A o ae?oae, oai?eo ia CAeA.

Aia?oa aeyaeaii oa?aiaaoe/iee aoaeo a?ae ii?aeiaiiai canoinoaaiiy *IEIE
? a?oai?io A a eiiieaeniiio e?eoaaii? ae?oae, oai?eo ia CAeA, caaaeyee
aeoeaaoe?? ee?oeiieo oa?iaio?a iecueei?ioaineaiei eaca?iei
aei?ii?ithaaiiyi ? aioeieneaeaioi?e ae?? a?oai?io A, ui a naith /a?ao
ni?ey? noaa?e?caoe?? ee?oeiieo iaia?ai, ciaioo? iaeiie/aiiy oiene/ieo
iaoaaie?o?a, noeioeth? ?ioii? ?aaeoe??.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ic?iaeaii oa cai?iiiiiaaii aeey
ai?iaaaeaeaiiy a i?aeoeeo iaoeiai iaa?oioiaai? iia? iaoiaee e?eoaaiiy
CAeA o ae?oae, ye? ia?aaeaa/athoue ei?aeoe?th ?ioiieia?/ieo ii?ooaiue,
neiae?iio A?, IIE oeyoii noi?niiai aeei?enoaiiy *IEIE ? a?oai?io A ia
oii? o?aaeeoe?eii? oa?ai??.

Aianai? aeiiiaiaiiy aei eaai?aoi?ieo iaoiae?a ?aiiuei? ae?aaiinoeee AeC
ca aeiiiiiaith aecia/aiiy a?eo?ioeeoa?ieo ?iaeaen?a.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo.

?acoeueoaoe iaoeiaeo aeine?aeaeaiue, ye? a?aeia?aaeai? a aeena?oaoe??,
ai?iaaaeaeai? a i?aeoeeo ?iaioe iaeanieo ? i?nueeeo aeeoy/eo e?ea?aiue,
a oaeiae iaeaniiai aoaeeieo aeeoeie i?no Oa?iii?eue ? ??aia.

Oai?aoe/i? iieiaeaiiy oa i?aeoe/i? ?aeiiaiaeaoe?? aeena?oaoe?? aeeth/ai?
a oeeee eaeoe?e oa i?aeoe/ieo caiyoue c iaae?ao??? aeey nooaeaio?a ia
eaoaae?? aeeoy/eo oai?ia iaaee/iiai oaeoeueoaoo Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai.

Aeaeaii: Iaoiaeeea canoinoaaiiy /a?acoe??ii? iaai?oieaca?ioa?ai?? a
eiiieaeniiio e?eoaaii? cae?ciaeao?oeeoii? aiai?? o ae?oae // ?ioi?i.
eeno ?55-98.– 2n.: Iioae. 02.07.98. (Ni?aaao.: Ni?yi ?.N.).

Iniaenoee aianie aeena?oaioa.

I?iaaaeaii ee?i?/ia niinoa?aaeaiiy, e?eoaaiiy e aiae?c eaai?aoi?ieo
iieaciee?a o 167 ae?oae, oai?eo ia aiai?th. Onoaiiaeaiee aca?iica’ycie
i?ae ee?i?/ieie i?iyaaie CAeA ? iieacieeaie iai?io cae?ca, ?ioi?oaoo,
IIE, A?. Iieacaiee nooi?iue iaoaaie?/ieo ii?ooaiue o caeaaeiino? a?ae
AeC. ?ic?iaeaii ee?i?ei-eaai?aoi?iee eiiieaen, oa?aeoa?iee aeey
neiae?iio A?. Iaa?oioiaai? ? ?ic?iaeai? noaie eiiieaenii? oa?ai?? CAeA c
aeei?enoaiiyi *IEIE ? a?oai?io A. I?iaaaeaia noaoenoe/ia ia?iaea
io?eiaieo ?acoeueoao?a, ?ic?iaeai? i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?iaioe.

Iniiai? iieiaeaiiy oa ?acoeueoaoe aeine?aeaeaiue aeena?oaoe?eii? ?iaioe
iaaiai?ai? ia iaoeiaiio can?aeaii? eaoaae? aeeoy/eo oai?ia iaaee/iiai
oaeoeueoaoo, iaae?ao??? oaeoeueoaoo i?neyaeeieiiii? ina?oe, iaoieia?/ii?
o?c?ieia?? Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. ?.ss.Ai?aa/aanueeiai (1998?.).

Iaoa??aee aeena?oaoe?? iaaiai?ai? ia iaoeiaeo eiioa?aioe?yo “Caeiaooee
ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie” (Oa?iii?eue, 1997, 1998??.),
I?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo
(Oa?iii?eue, 1997, 1998??.), iaoeiai-i?aeoe/i?e eiioa?aioe?? “No/ani?
i?iaeaie aaiaoieia?? oa o?ainooc?ieia??” (Ee?a, 1998?.), ??-?e
eiioa?aioe?? Anioe?aoe?? aeeoy/eo e?ea??a Oe?a?ie
“E?eoaaeueii-i?io?eaeoe/ia oa?/oaaiiy oa i?ia?ioeee a iaae?ao???” (Ee?a,
1998?.), iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? ieoaiiy ee?i?/ii?
iaaeeoeeie oa aeieia??” (Iieoaaa, 1998?.), ee?i?/i?e eiioa?aioe??
Anioe?aoe?? aeeoy/eo e?ea??a iaeano? (1997, 1998??.).

Ioae?eaoe??.

Ca oaiith aeena?oaoe?? iioae?eiaaii 15 ?ia?o: 5 noaoae o i?ia?aeieo
aeo?iaeao, 2 – o ca??ieeao iaoeiaeo i?aoeue, 4 – o iaoa??aeao, 4 – o
oacao iaoeiai-i?aeoe/ieo eiioa?aioe?e.

Ianya ? no?oeoo?a aeena?oaoe??.

Aeena?oaoe?y aeeeaaeaia ia 165 noi??ieao iaoeiiieno. Neeaaea?oueny c?
anooio, iaeyaeo e?oa?aoo?e, iieno iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy,
2 ?icae?e?a aeanieo aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, ia?ae?eo aeei?enoaieo aeaea?ae, yeee aeeth/a?
223 iaeiaioaaiiy (c ieo oe?a?inueeith oa ?in?enueeith iiaaie – 168,
?iicaiieie – 55) ? caeia? 20 noi??iie. ?iaioa ?ethno?iaaia 36
oaaeeoeyie, 15 ?enoieaie, ye? caeiathoue 52 noi?i?ee.

Ci?no ?iaioe

Ia’?eo ? iaoiaee aeine?aeaeaiiy.

O ?iaio? iaaaaeai? ?acoeueoaoe aeine?aeaeaiue i?ioyaii 1996-1998??. o
167 ae?oae, oai?eo ia CAeA, o a?oe? a?ae 3 aei 14 ?ie?a. Ee?i?/ia ?
eaai?aoi?ia ianoaaeaiiy ae?oae i?iaiaeeeinue o Oa?iii?euenuee?e iaeani?e
? i?nuee?e aeeoy/?e e?ea?i?, Oa?iii?euenueeiio ? ??aiainueeiio aoaeeieo
aeeoeie, ??aiainueeiio ee?i?/iiio e?eoaaeueii-ae?aaiinoe/iiio oeaio??.

I?e anoaiiaeaii? ae?aaiico a?aoiaoaaee aiaiiac, aeai?
caaaeueiii?eeiyoiai ia’?eoeaiiai ianoaaeaiiy i?aai?a ? nenoai,
eaai?aoi?i? e ?ino?oiaioaeuei? aeine?aeaeaiiy, ?acoeueoaoe iaeyaeo
noi?aeieo niaoe?ae?no?a.

?c eaai?aoi?ieo ianoaaeaiue, e??i caaaeueiiai aiae?co e?ia?, na/?, eaeo,
ioe?ithaaee a?io?i?/i? iieacieee (aetheica e?ia?, a?e??oa?i, a?eie ?
eiai o?aeoe??, o?ainai?iace), aaiaoie?eo (Ht), a oaeiae aecia/aee
a?eo?ioeeoa?i? ?iaeaene: na?aaei?e ia’?i a?eo?ioeeoa (MCV), na?aaei?e
ai?no aaiiaeia?io a a?eo?ioeeo? (INI), na?aaeith eiioeaio?aoe?th
aaiiaeia?io a a?eo?ioeeo? (ININ), ?iaeaen ?iciiae?eo a?eo?ioeeo?a (RDW).
Aeacai? aeai? io?eioaaee ia aaiaoieia?/iiio aiae?caoi?? Micros Cobas
o??ie “Roche” aai ?ic?aooieiaei iaoiaeii. Ioe?ithaaee ai?no cae?ca
ne?iaaoee e?ia? (CN) ? caaaeueio cae?cia’ycoth/o caeaoi?noue ne?iaaoee
(CCCN), ye? aecia/aee ca aeiiiiiaith iaai??a A?i-Ea-Oano o??ie “Eaoaia”.

Ae?aoiaoaaee oaeiae eiao?oe??io iane/aiiy o?ainoa?eio (EIO) cae?cii:

Ae?aaiic aiai?? aenoaaeyee o a?aeiia?aeiino? c ?aeiiaiaeaoe?yie AIIC
(1973).

Aeey ioe?iee ?ioiieia?/iiai noaoono ianoaaeaieo ae?oae aecia/aee O
(A-?OE), A (AAN-?OE) oa ioeueia? (0) – e?ioioeeoe ca iaoiaeii
N.F.Mendes et al. (1973) o iiaeeo?eaoe?? O.?.A??oeii? ? ni?aaao. (1984).
“Aeoeai?” O-e?ioioeeoe (AA-?OE) i?ae?aoiaoaaee ca iaoiaeii L.Wybran
(1973). Noaiiioeyoe?? ?aaoeyoi?ieo O-e?ioioeeo?a aecia/aee ca ?o
/ooeea?noth aei oaio?e?io ca iaoiaeii J.Limatibul et al.(1978):
O-noi?ani?e (O*-?OE) – oaio?e?i/ooeea?, O-oaeia?e (O?-?OE) –
oaio?e?i?acenoaioi?. Aeanoeaino? A-e?ioioeeo?a ioe?ithaaee ca
iieacieeaie ?ioiiaeiaoe?i?a eean?a G, A, I iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? a aae? G.Manchini et al. (1965).

Nooi?iue ae?aaeaiino? iaia?aiiaeano?oeoeaieo i?ioean?a i?iaiaeeeinue
aecia/aiiyi iaeiiiaiai aeeaeueaeaa?aeo (IAeA) ca iaoiaeii ?.Ae.Noaeueii?
(1977).

Ioe?ieo aioeieneaeaioii? nenoaie caoenoo (AINC) i?aai?cio i?iaiaeeee ca
iieacieeaie noia?ieneaeaeeniooace (NIAe), yeo aecia/aee a a?eo?ioeeoao
ca iaoiaeii N.*aaa?e ? ni?aaao. (1985) o iiaeeo?eaoe?? I.A.Aeoa?i?ii?
(1993), eaoaeace (E) ? oea?oeiieaci?io (OeI) o ne?iaaooe? e?ia? ca
iaoiaeii N.?aaeia (1987).

Aeey aeine?aeaeaiiy neiae?iio aiaeiaaiii? ?ioieneeaoe?? (A?)
i?iaiaeeeinue aecia/aiiy a a?eo?ioeeoao iieaeoe na?aaeiuei? iane (INI)
ca iaoiaeeeith I.?.Ee?a?aa ? ni?aaa. (1990). I?e aeiaaeei? oaee? 254 ii
aecia/aee INI1, ui i?noyoue ioeeaioeaee, i?e aeiaaeei? oaee? 280 ii, –
INI2, ui i?noyoue a?iiaoe/i? eeneioe. A?eo?ioeeoa?iee ?iaeaen
aiaeiaaiii? ?ioieneeaoe?? (A?A?) anoaiiaethaaee ca iaoiaeii
A.A.Oiaaeaa?aa ? ni?aaao. (1988).

Noaoenoe/ia ia?iaea aeaieo aeine?aeaeaiue i?iaiaeeeany ca aeiiiiiaith
i?eeeaaeieo noaoenoe/ieo i?ia?ai ia ia?niiaeueiiio eiii’thoa?? oeio ?AI.

Eiio?ieueio a?oio neeaee 20 ae?oae a?eii a?ae 3 aei 14 ?ie?a aac
ee?i?/ieo ? eaai?aoi?ieo iciae CAeA oa noiooiuei? iaoieia??.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy.

O 55.09% ianoaaeaieo ae?oae ae?aaiinoiaaii CAeA ? nooiaiy (? a?oia), o
27.54% – CAeA ?? nooiaiy (?? a?oia), o 17.37% – CAeA ??? nooiaiy (???
a?oia). Oeii/ee?a aoei 49.7%, ae?a/aoie – 50.3%.

Aeine?aeaeaiiy iieacaee, ui an? nooiai? oyaeeino? CAeA cono??/aeeny
/ano?oa a oeii/ee?a o a?oe? 3-5 ?ie?a, a a ae?a/aoie – o a?oe? 6-14
?ie?a.

I?ia?aoe ioe?ieo aiaiiaco ianoaaeaieo ae?oae, aoei anoaiiaeaii
iaaeaaiiieo//y a aioa- ? iaiiaoaeueiiio ia??iae? a 76.64% aeiaaeeao.
Aiai?y o iaoa?? i?ae /an aaa?oiino? anoaiiaeaia a 73.75% ae?oae 3-5
?ie?a ? a 64.37% ae?oae 6-14 ?ie?a. Ia ia?oiio ?ioe? aeeooy o 2/3 ae?oae
a?aecia/aeenue a?aeoeeaiiy a i?aii?a?aeiiio oii?: oae, ia ooo/iiio
aeaiaeiaoaaii? ia?aaoaaei 63.47% ae?oae.

Aeiaaio?eaaeee AeC iaaaoeaii iicia/aany ia ooieoe?iiaeueiiio noai?
i?aai?a ? nenoai, oi?ioaaii? noiooiuei? aino?i? oa o?ii?/ii?
?ioaeoe?eii? iaoieia?? (61.08%), yea a iaeieo aeiaaeeao ia?aaeoaaea
?icaeoeo CAeA (46.71%), a a ?ioeo – ?icaeaaeany ia ?? oii? (53.29%).

Ee?i?/ia ea?oeia ianoaaeoaaieo oai?eo oa?aeoa?ecoaaeany iie?ii?o?ciii
noa’?eoeaieo ? ia’?eoeaieo iciae caoai?thaaiiy, ye? iiaeia ia’?aeiaoe a
oae? neiae?iie: aiaeiaaiii? ?ioieneeaoe??, neaea?iiai?/iee,
na?oeaai-noaeeiiee.

Ae?aaeai?noue oeeo neiae?ii?a caeaaeaea a?ae nooiaiy CAeA, a?eo ae?oae,
o?eaaeino? caoai?thaaiiy oa iayaiino? noiooiuei? ?ioaeoe?eii? iaoieia??.

I?e a?iien??, yea ? iaoiaaiaoe/iith iniiaith CAeA, noai?ththoueny oiiae
aeey iaeiie/aiiy aiaeiaaiieo oienei?a, i?iyaii /iai ? neiae?ii
aiaeiaaiii? ?ioieneeaoe?? (NA?), yeee aoa iaeiioe?ai?oei ? niinoa??aaany
o 66.46% ianoaaeaieo ae?oae. Oea aoee ae?oe, oai?? ia CAeA na?aaeiueiai
oa oyaeeiai nooiai?a. Ee?i?/i? iciaee NA? aoee iie?ii?oieie ? iaee
ianiaoeeo?/iee oa?aeoa?. Anoaiiiaa?ioe/i? neiioiie (eaie?noue,
ae?ao?aeea?noue, caiaii?i/aiiy, aieiaiee a?eue) o?aeooaaeenue ye iaei? c
ia?oeo i?iya?a NA? (?.N.Ni?yi, 1994, 1998). I?e ia’?eoeaiiio ianoaaeaii?
a ae?oae, oai?eo ia CAeA, aoee ciaeaeai? iciaee o?ii?/ii? ?ioieneeaoe??:
ia?ei?aeueia oa ia?ei?a?oaeueia ae?ae?noue ? n???noue, ?icoe?aiiy
eai?ey?ii? n?oee a i?aeeiiaoeia?e ae?eyioe?, ui oaeiae ? iciaeaie A?.

Neaea?iiai?/iee neiae?ii (64.67%), yeee aeeth/aa ci?ie oe??e oa ??
i?eaeaoe?a, o ae?oae c oyaeeei nooiaiai CAeA cono??/aany a 3.7 ?ac?a
/ano?oa, i?ae i?e eaaeiio nooiai? CAeA. C iiaeeaeaiiyi AeC ci?ithaaany
oaeiae oa?aeoa? neiioii?a oeueiai neiae?iio. sseui i?e eaaeiio nooiai?
ia?aaaaeaea iii??ia ae?ae?noue neeciaeo ? oe??ieo iie?ea?a, oi i?e
na?aaeiueiio ? oyaeeiio nooiai? CAeA oe??a iaaoaaea n??iai a?aeo?ieo,
ia?inoaee o?io?/i? ?iceaaee, noo?noue ? eouaiiy oe??e (44.91%), aiaieua
aeai?aiaioaoe?? (2.99%), iiaaiee ??no, eaie?noue ? aeiaaeaiiy aieinny
(27.42%).

Aei i?iya?a neaea?iiai?/iiai neiae?iio oaeiae a?aeiinyoueny
ai?oae?aeuei? ?iceaaee. Oae, o 9.41% ae?oae 3-5 ?ie?a a?aecia/aeiny
niioai?aiiy niaeo ? aiaoeoo: ae?oe ?ee e?aeaeo, iai??, caieth.

A ianoaaeaieo ae?oae anoaiiaeaii o?aaeaiiy neeciaeo iaieiiie
oeoieiai-eeoeiaiai o?aeoo, ui i?iyaeyeinue aiaoey?iei noiiaoeoii
(4.79%), caeaaeaeai?noth neeciai? yceea (17.36%) aioa?iiao??th (30.4%),
noaao?io?/iei aano?iaeoiaeai?oii (17.24%), i?aeoaa?aeaeaiei
?acoeueoaoaie aano?iaeoiaeaiineii??.

Aiai?/ia a?iien?y, a oaeiae cieaeaiee a ?acoeueoao? AeC neioac
i?iaeia?io ? cae?ciai?nieo oa?iaio?a (A.A.Aoaeaiia, A.A.Nayaeia,
A.O.Oo?aaa, 1991), cia/ii aieeaathoue ia ooieoe?th na?oeaaiai i’yco.
Na?oeaai-noaeeiiee neiae?ii ae?aaiinoiaaii 43.11% oai?eo ae?oae. Oea
aoee ae?oe ia?aaaaeii c ae?oaei ? o?ao?i nooiaiai CAeA.

I?iyaii na?oeaai-noaeeiiiai neiae?iio aoee nea?ae ea?ae?aeueiiai
oa?aeoa?o (64.36%) , a oaeiae o?c?eaeuei? ci?ie: ineaaeaiiy na?oeaaeo
oii?a (43.81%), oao?ea?ae?y (37.5%), iineaaeaiiy ia?oiai oiio ?
nenoie?/iee ooi iaae aa?o?aeith na?oey (60.83%). O 17.4% anoaiiaeaii
?icoe?aiiy ae?ai a?aieoe? na?oey.

AEA oa?aeoa?ecoaaeanue cieaeaiiyi aieueoaaeo coaoe?a, ?icoe?aiiyi coaoey
? (14.8%), cieaeaiiyi aai aeaioaci?noth coaoey O (24.63%), aeai?an??th
naaiaioo S-O (27.3%).

Eaai?aoi?ia ianoaaeaiiy oai?eo ae?oae aeicaieeei aeae?eeoe oae?
iieacieee aaiiaeia?io (Hb) ? a?eo?ioeeo?a i?e ??cieo nooiaiyo CAeA. I?e
eaaeiio nooiai? CAeA ??aaiue Hb neeaaeaa 92-117 a/e, e?euee?noue
a?eo?ioeeo?a – 3.8-4.2·1012/e. Na?aaei?e nooi?iue CAeA oa?aeoa?ecoaaany
eieeaaiiyi Hb 75-92 a/e, a?eo?ioeeo?a – 2.6-3.8·1012/e. I?e oyaeeiio
nooiai? ??aaiue Hb aoa ieae/a 75 a/e, a?eo?ioeeo?a – ieae/a 2.7·1012/e.

I?e ioe?ioe? a?eo?ioeeoa?ieo ?iaeaen?a e?ia? a?aecia/aii, ui aiai?y iaea
a?iio?iiiee i?e?ioeeoa?iee oa?aeoa?, oae, c ia?inoaiiyi oyaeeino? CAeA
ciaiooaaeeny MCV, MCH, MCHC, ia?inoaa ai?cioeeoic.

MCV noaiiaea i?e oyaeeiio nooiai? CAeA 61.69±1.00 oe, a i?e eaaeiio ?
na?aaeiueiio nooiaiyo – 78.57±0.58 oe ? 75.88±0.86 oe a?aeiia?aeii; o
eiio?ie? – 83.45±0.44 oe (P<0.01). ?iaeaen ?iciiae?eo a?eo?ioeeo?a (RDW), yeee aea? e?euee?nio ioe?ieo ?iceeaeo a?eo?ioeeo?a ca ia’?iii ? aeicaiey? iai/ii ioe?ieoe nooi?iue ai?cioeeoico, i?e na?aaeiueiio (15.79±0.48%) oa oyaeeiio nooiai? (18.36±0.66%) CAeA aoa cia/ii aeuei (P<0.05), i?ae o ae?oae ?c eaaeei nooiaiai CAeA (13.36±0.26%), a eiio?ie? – 13.04±0.15%. I?e/iio ci?ie RDW o 9.58% ae?oae iaee i?noea iaa?oue i?e ua ii?iaeueiiio ia’?i? a?eo?ioeeoa, ui aeicaiey? aaaaeaoe RDW iaeiei ?c ?aii?o /ooeeaeo a?eo?ioeeoa?ieo ?iaeaen?a aeey aeyaeaiiy AeC (TH.A.Eociaoeiaa, 1996). I?e aecia/aii? ??aiy CN a?aecia/aii, ui a?i cieaeoaaany aaeaeaaoii nooiaith CAeA ? i?e oyaeeiio ia?aa?ao CAeA aoa o 2 ?ace ieae/ei (7.30±0.32 ieiieue/e) ca iieaciee o eiio?ieuei?e a?oi? ae?oae (14.11±0.48 ieiieue/e), P<0.01. Ia?aeaeueii cieaeaiith CN ciaiooaaany EIO ? aeinoia??ii i?aeaeuoaaeany CCCN, yea i?e oyaeeiio nooiai? CAeA noaiiaeea 81.10±2.97 ieiieue/e, a a eiio?ie? – 62.00±1.64 ieiieue/e, P<0.01. A?aoiaoth/e aaaeeea?noue ?ioiieo ?aaeoe?e o iaoiaaiac? CAeA, iayai?noue o ianoaaeaieo ae?oae aino?eo ? o?ii?/ieo aiaieu ?ioaeoe??, noeeuei?noue ae?oae ?c AeC aei iiaoi?iiai ?io?eoaaiiy, aoa i?iaaaeaiee aiae?c iieaciee?a ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo a 126 ae?oae. Ca ?acoeueoaoaie aeanieo aeine?aeaeaiue aeyaeaii nooo?aa i?eai?/aiiy O-ee?oeiii? eaiee ?ioi?oaoo. Ia?aeaeueii niinoa??aaee cieaeaiiy ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a ? ca?eueoaiiy iac??eeo oi?i I-ee?oei. Oea na?ae/eoue i?i ao?aoo ?ioiieia?/ii? eiiiaoaioiino? /anoeie O-e?ioioeeo?a, cao?eieo ?o o?ainoi?iaoe?? a oiiaao AeC a c??e? oi?ie, aiane?aeie ia?aaaioaaeaiiy ?ioiii? nenoaie iecueeiiieaeoey?ieie oieneiaie. I?e aiae?c? ai?noo ?ioii?aaoeyoi?ieo O-ee?oei aeyaeaii cia/ia cieaeaiiy O*-?OE ? O?-?OE. Oae, i?e oyaeeiio nooiai? CAeA a?aeiiniee ai?no O-noi?ani??a aoa ieae/ei, i?ae o caei?iaeo ae?oae o 2 ?ace, a O-oaeia??a – o 1.5 ?ace. Aeyaeaii i?yiee ei?aeyoeaiee ca’ycie i?ae CN ? O-e?ioioeeoaie i?e ?? ? ??? no. CAeA (r=+0.41; +0.37; P<0.05), i?ae CN ? O-aeoeaieie e?ioioeeoaie (r=+0.38; r=+0.46; P<0.05). I?e an?o nooiaiyo CAeA anoaiiaeaii cai?ioi?e ei?aeyoeaiee ca’ycie i?ae CN ? O-ioeueiaeie e?ioioeeoaie. Oe? aeai? na?ae/aoue i?i i?eai?/oth/o ae?th AeC ia ee?oeiio eaieo ?ioi?oaoo (TH.A.Iaeaoianeee e ae?., 1988). ??aaiue A-e?ioioeeo?a o ianoaaeaieo ae?oae oaeiae caeaaeaa a?ae nooiaiy AeC, ? e?euee?noue A-e?ioioeeo?a cieaeoaaeany ia?aeaeueii ia?inoaiith i?iya?a CAeA. Aea/aiiy ??aiy ?ioiiaeiaoe?i?a G, A, M aeacoaaei ia eieeaaiiy ai?noo inoaii?o o ne?iaaooe? e?ia? i?e CAeA. Oae, eiioeaio?aoe?y Ig G i?e an?o nooiaiyo oyaeeino? CAeA aoea yaii ieae/ith (P<0.001), i?ae o eiio?ieuei?e a?oi?. Oey ??cieoey aeyaeeany iaea?eueo ae?aaeaiith o oai?eo ?c oyaeeei nooiaiai CAeA, aea ??aaiue Ig G neeaaeaa 6.37±0.11 a/e, a a eiio?ie? – 9.08±0.27 a/e. Ai?no Ig A i?e ? ? ?? nooiaiyo CAeA aoa iaci?iiee, a i?e ??? – cieaeaiee (P<0.01). Ai?no Ig M i?aeaeuoaaany a i??o ia?inoaiiy AeC, ui iiaea aooe aeieacii noeeueiino? ae?oae ?c CAeA aei ?io?eoaaiiy. ? i?aenoaae aaaaeaoe, ui oiiiaa iaoieia?y, o naith /a?ao, aoaea iaoyaeeeai aieeaaoe ia ia?aa?a aiai?? ? cieaeoaaoe aoaeoeai?noue ?? oa?ai??. Aeey ioe?iee noaio aeanoaa?e?coth/eo i?ioean?a, ye? aeieeathoue a i?aai?ci? i?e AeC, ei?enooaaeenue iieacieeii IIE–IAeA ? oa?iaioaie AINC–NIAe, E, OeI. I?e oeueiio aeyaeaii, ui ia?inoaiiy oyaeeino? aiai?? noi?iaiaeaeoaaeinue aeoeaaoe??th ia?ieneaeaoe?? e?i?ae?a (?en. 1): oae, ??aaiue IAeA aoa iaeaeuei i?e ??? nooiai? CAeA – 5.28±0.20 ieiieue/e (P<0.001), ui a 1.8 ?ace ia?aaeuoaaei aeai? eiio?ieueii? a?oie. Uiaei aeaaiino? caoai?thaaiiy, oi i?e o?eaaeino? CAeA a?eueoa o?ueio ?ie?a ??aaiue IAeA aoa iaeaea a aeaa ?ace aeuei (6.11±0.32 ieiieue/e), i?ae i?e o?eaaeino? iaoieia?? aei iaeiiai ?ieo (3.98±0.71 ieiieue/e, P<0.05). I/aaeaeii, o?eaaea a?iien?y aieeaa? ia ?ioaineai?noue IIE, ui i?aeoaa?aeaeo?oueny cai?ioi?i ei?aeyoe?eiei ca’yceii i?ae CN, Hb i IAeA. Aeaeici?ie no?oeoo?e a?ieia?/ieo iaia?ai coiiaeee ia?aaoaeiao AINC. Oae, aeoeai?noue aioo??oiueiee?oeiieo oa?iaio?a NIAe ? E cieaeoaaeanue o i??o ia?inoaiiy aeao?oeeoo cae?ca (P<0.001). O ii??aiyii? c eiio?ieueiith a?oiith, ??aaiue NIAe i?e oyaeeiio nooiai? CAeA cieaeoaaany ia 38.6%, a ??aaiue E – ia 45.2%. Io?eiai? ?acoeueoaoe iieaciee?a IAeA, NIAe, E o ae?oae, oai?eo ia CAeA, ni?aiaaeathoue ?c aeine?aeaeaiiyie ?ioeo aaoi??a (A.A.Eeeiaiia, O.A.Naaeeeia, 1997). I?e ii?aeiaii? CAeA c ?ioaeoe?eiith iaoieia??th iniaeeai ae?aaeai? aoee ci?ie E, ??aaiue yei? o oe??? a?oie ae?oae nyaaa 9.65±0.27 oi.iae. ii??aiyii c 10.44±0.26 oi.iae. o a?oie ae?oae aac noiooiuei? ?ioaeoe?eii? iaoieia?? (P<0.05). Iaea?iaaia aeoeaaoe?y IIE i?e a?aenooiino? iaeaaeii? a?aeiia?ae? AINC aieeaa? ia ooieoe?iiaeueio aeoeai?noue iicaee?oeiieo oa?iaio?a. Oae, ??aaiue OeI i?e o?aoueiio nooiai? CAeA ca?eueooaaany a 1.6 ?ace a ii??aiyii? c eiio?ieueiith a?oiith. A?aoiaoth/e ?yae ia?aaeoiia aeey aeieeiaiiy NA? i?e CAeA, a naia: a?iien?th, ?ioiieia?/i? c?ooaiiy, aeac?ioaa?aoe?th IIE, i?iaiaeeeiny aea/aiiy ia?ea??a NA? – iieaeoe na?aaeiuei? iane (oaae. 1). ?acoeueoaoe ianoaaeaiue iieacaee, ui a ae?oae, oai?eo ia CAeA, aiie aoee i?aeaeuai? ? nyaaee iaeneioio i?e oyaeeiio nooiai? CAeA: 460.64±12.34 oi.iae. ? 269.55±7.68 oi.iae. a?aeiia?aeii (P<0.001), ui a 1.5 ? 1.8 ?ac?a ia?aaeuoaaei oe? iieacieee a ae?oae eiio?ieueii? a?oie. Nooi?iue oiene/ieo aieea?a INI ? i?iaeoeo?a IIE ia iaia?aie a?eo?ioeeo?a ioe?ithaaee ca ??aiai A?A?. I?e an?o nooiaiyo oyaeeino? CAeA A?A? aoa aeinoia??ii i?aeaeuaiei (P<0.001) ii??aiyii c eiio?ieai – 24.39±0.34% – ? aoa iaea?eueoei i?e ??? no. CAeA – 41±0.5%. Iaa?iaiee na?aaei?e ei?aeyoe?eiee ca’ycie i?ae CN ? A?A? i?e ?? ? ??? nooiai? CAeA (r=-0.43; -0.52), (P<0.05) na?ae/eoue i?i aca?iica’ycie i?ae ciaioaiiyi caian?a cae?ca ? ca?eueoaiiyi A?A?. Ioaea, iaoaaie?/i? ci?ie o ae?oae, oai?eo ia CAeA, noai?ththoue caieiooa eiei c ia?inoaiiyi a?iien??, iineeaiiyi IIE, cieaeaiiyi aeoeaiino? nenoaie aioeieneaeaioiiai caoenoo, iaa?iiaaeaeaiiyi oiene/ieo i?iaeoeo?a iai?io ? ?icaeoeii ?ioieneeaoe??. I?yia caeaaei?noue i?ae nooiaiai AeC ? i?iyaaie NA? na?ae/eoue i?i i?ia?aeio ?ieue neaea?iiai?? a oe?e eaioethaia?e ?aaeoe??. Iie?ii?o?ci ee?i?/ieo ? iaoaaie?/ieo ii?ooaiue ia?aaeaa/a? eiiieaeniee i?aeo?ae aei oa?ai??, yeee ae aieeaaa ia an? aeuaia?a?aoiaai? eaiee CAeA oa ni?eya oaeaeo?e ?aaa?e?oaoe?? aeeoeie. O ?iaio? aoei ai?iaiaaii o?e eiiieaene e?eoaaiiy AeC. Aeey oeueiai aoei aeae?eaii o?e a?oie ii 30 ae?oae o eiaei?e. Oe? ae?oe a eiaei?e a?oi?, caeaaeii a?ae a?eo oa nooiaiy oyaeeino? CAeA, aoee i?ae?a?ai? oaeei /eiii: ii 5 ae?oae a?eii 3-5 ?ie?a oa ii 5 ae?oae a?eii 6-14 ?ie?a, oai?eo ia CAeA ?, ?? oa ??? nooiai?a oyaeeino?. Ia?oa a?oia (n=30) io?eioaaea aaciaa e?eoaaiiy o aeaeyae? i?aia?ao?a cae?ca a aeic? 5 ia/ea/aeiao, iie?a?oai?i?a oa oa?iaio?a o a?eia?e aeic?. Ae?oa?e a?oi? (n=30), e??i aaciai? oa?ai??, i?iaiaeeeiny *IEIE, e?euee?noue naain?a yeiai, o?eaae?noue i?ioeaaeo?e oa iiooaei?noue aei?ii?ithaaiiy caeaaeaee a?ae a?eo aeeoeie. Oae, aeey ae?oae 3-6 ?ie?a o?eaae?noue i?ioeaaeo?e aoea 5 oa., iiooaei?noue aei?ii?ithaaiiy ia aeoiae? iaai?oii? ianaaeee – 8 iAo. E?euee?noue i?ioeaaeo? – 6. O ae?oae 7-10 ?ie?a oe? iieacieee noaiiaeee a?aeiia?aeii 7 oa., 12 iAo, 7 i?ioeaaeo?, o ae?oae i?ney 10 ?ie?a – 9 oa., 15 iAo, 8 i?ioeaaeo?. O?aoy a?oia (n=30), e??i i?aia?ao?a cae?ca oa *IEIE, io?eioaaea a?oai?i A, yeee aieiae?? aioeieneaeaioiith ae??th a aeic? 2 ia/ea iaeei ?ac ia aeiao i?ioyaii 14 aei?a. Ca ?acoeueoaoaie aeine?aeaeaiiy anoaiiaeaii, ui o ae?oae ia?oi? a?oie ia a?aeaoeiny ae?aaeaieo iiceoeaieo ci?i ye o ee?i?/i?e ea?oei? caoai?thaaiiy, oae ? a iieacieeao ia?eoa?e/ii? /a?aiii? e?ia?, CN ? CCCN. Oae, iciaee NA? caeeoeeeny ia 21 aeaiue e?eoaaiiy o 63.3% ae?oae ?c ?? oa ??? nooiaiai CAeA, ae?aaeai?noue neaea?iiai?/iiai neiae?iio ciaioeeanue eeoa a 9 ae?oae. Oo?eioaaeeny nea?ae ia caaaeueio a’ye?noue, neaa?noue, oaeaeeo aoiiethaai?noue, iiaaiee aiaoeo. Ne?ae cacia/eoe, ui a eiaei?e a?oi? iiceoeaia aeeiai?ea ee?i?/ieo neiae?ii?a a?aecia/aeany oei oaeaeoa, /ei iaioee aeao?oeeo cae?ca aoa o aeeoeie. O ae?oae ?? a?oie, ye?, e??i i?aia?ao?a cae?ca, io?eioaaee *IEIE, niinoa??aaeenue a?eueo ae?aaeai? iiceoeai? ci?ie a ee?i?/iiio ia?aa?ao caoai?thaaiiy. Oae, i?iyae NA? cia/ii ciaioeeenue o 36.3% ae?oae. Ia?anoaea oo?aoaaoe eaie?noue, ae?ao?aeea?noue. I?iyae neaea?iiai?/iiai neiae?iio cieeee a 66.6% ianoaaeaieo ae?oae ?? a?oie, o 72.3% cieeea oaiaeaioe?y aei oao?ea?ae??, ci?ie a?iiene/iiai oa?aeoa?o ia AEA noaee iaio ae?aaeaieie. “Aiai?/iee” ooi ia aa?o?aoe? i?iaeiaaeoaaa oo?eioaaoenue. O ae?oae ??? a?oie, ye?, e??i ia?a?aoiaaii? oa?ai??, aeiaeaoeiai io?eioaaee a?oai?i A, iiceoeai? ci?ie ee?i?/ii? ea?oeie ianoaaaee c 4-5 naaino *IEIE, ia a?aei?io a?ae ae?oae ?? a?oie, o yeeo iiae?ai? ci?ie ianoaaaee eeoa i?ney 7-8 naaino. Oae, ia 21-e aeaiue e?eoaaiiy i?iyae NA? caeeoeeeny eeoa a 9 ae?oae (30%), oiae? ye o ia?o?e ? ae?oa?e a?oiao oe? iieacieee noaiiaeee a?aeiia?aeii 63.3% ? 36.7%. Aecia/aiiy aeeiai?ee iieaciee?a ia?eoa?e/ii? /a?aiii? e?ia? a ianoaaeoaaieo a?oiao iieacaei ?o i?aeaeuaiiy a ii??aiyii? c iieacieeaie aei e?eoaaiiy iacaeaaeii a?ae aeaeo oa?ai??. I?ioa, yeui o ia?o?e a?oi? caaaeueiee i?e??no aaiiaeia?io neeaaeaa 9.9 a/e, a iiaeiaiaee – 0.47 a/e, oi a ?? ? ??? a?oiao oe? iieacieee aoee aeinoia??ii aeueie (P<0.05) ? neeaaeaee a?aeiia?aeii: 11.47 a/e ? 0.56 a/e, 19.83 a/e ? 0.94 a/e. A ianoaaeaieo ae?oae uiaeiaiaee i?e??no aaiiaeia?io aoa oei aeuee, /ei ieae/ei aoa eiai aeo?aeiee ??aaiue. O ae?oae ? a?oie i?ney aaciaiai e?eoaaiiy niinoa??aaeany eeoa oaiaeaioe?y aei i?aeaeuaiiy e?eueeino? a?eo?ioeeo?a, EI, Ht, MCV, MCH, MCHC ? oaiaeaioe?y aei cieaeaiiy RDW (P>0.05), oiae? eiee a ?? ? ???
a?oiao niinoa??aaeinue ?o aeinoia??ia i?aeaeuaiiy (P<0.05), e??i RDW, yeee iaa, ciiao ae oaee, eeoa oaiaeaioe?th aei cieaeaiiy (P>0.05). E??i
oiai, o ae?oae ??? a?oie iieacieee aeinoia??ii ia a?ae??ciyeenue a?ae
cia/aiue o eiio?ieuei?e a?oi? (P>0.05), e??i RDW (P<0.05). Oaeiae caa?aaeany aeinoia??ia ??cieoey i?ae oeeie iieacieeaie i?ney ??cieo iaoiae?a e?eoaaiiy o ii??aiyii? i?ae ??? oa ? a?oiaie (P<0.05). O ae?oae, ye? io?eioaaee eiiieaenia e?eoaaiiy CAeA (??? a?oia), a?aecia/aeiny iaea?eueo ae?aaeaia ca?eueoaiiy ??aiy CN, ciaioaiiy CCCN oa ca?eueoaiiy EIO: 12.91±0.43 ieiieue/e; 62.26±1.41 ieiieue/e; 20.85±0.92%, ? oe? cia/aiiy aeinoia??ii ia a?ae??ciyeeny a?ae iieaciee?a o eiio?ieuei?e a?oi? (P>0.05).

*IEIE o ii?aeiaii? c a?oai?iii A, yeee aieiae?? aioeieneaeaioiith
ae??th, i?eaiaeeei aei ii?iae?caoe?? ye?nieo ? e?euee?nieo iieaciee?a
ia?eoa?e/ii? /a?aiii? e?ia?, CN, CCCN, EIO. Oea a?aeaoaa?oueny /a?ac
noeioeyoe?th a?eo?iiiaca oa aaiiaeia?iiooai?aiiy I?EA (E.?.?iiai/oe ?
ni?aaao., 1997, ?.C.Naiinthe ? ni?aaao., 1997, N.A.Oi?eue, 1994).

Canoinoaaiiy *IEIE iiceoeaii aieeioei ia ee?oeiio oa aoii?aeueio eaiee
?ioi?oaoo. Oae, niinoa??aaeinue aeinoia??ia i?aeaeuaiiy (P<0.05) ai?noo A-?OE, ye o aaniethoiiio, oae ? o a?aeiiniiio ae?aaeaiiyo o ae?oae ?? oa ??? a?oi. E?euee?noue AA-?OE aoea aeinoia??ii ca?eueoaiith o ae?oae ?? oa ??? a?oi (P<0.05) ? iaea eeoa oaiaeaioe?th aei ca?eueoaiiy a ae?oae ia?oi? a?oie, i/aaeaeii, ie?aii acyoa oa?ioa?ai?y ia ? aeinoaoiueith aeey a?aeiiaeaiiy ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a. Niinoa??aaeiny ciaioaiiy a?aeiinii? e?eueeino? I-e?ioioeeo?a i?ney eiiieaeniiai e?eoaaiiy a ae?oae ??? a?oie (P<0.001) ? a?aecia/aia aeinoia??ia ??cieoey oeueiai iieacieea ii??aiyii c ?? oa ? a?oiaie (P<0.001). Ai?no ?ioii?aaoeyoi?ieo noaiiioeyoe?e O-e?ioioeeo?a o ae?oae ??? a?oie i?aeaeueany (P<0.001) ? aeinoia??ii a?ae cia/aiue o eiio?ieuei?e a?oi? ia a?ae??ciyany (P>0.05), a o a?aeiinieo cia/aiiyo
aoa aeinoia??ii aeuei, i?ae o ?? oa ? a?oiao (P<0.05). ??aaiue ?ioiiaeiaoe?i?a o?ueio eean?a o ??? a?oi? iaaeeceany aei cia/aiue o eiio?ie? (P>0.05). ??cieoey o ??ai? Ig G oa Ig M i?ae a?oiaie
aoea aeinoia??iith (P<0.05) eeoa i?e ii??aiyii? i?ae ??? oa ? a?oiaie. Aecia/aiiy aeeiai?ee ??aiy IAeA o o?ueio a?oiao iieacaei ?o aeinoia??ia ciaioaiiy (P<0.05) o ii??aiyii? c iieacieeaie aei e?eoaaiiy eeoa a ?? oa ??? a?oiao. Oaeiae a?aecia/aii i?aeaeuaiiy (P<0.001) ??aiy E ? NIAe o ae?oae ?? a?oie oa ciaioaiiy iicaee?oeiiiai oa?iaioo OeI o 1.4 ?ace, ui iiynith?oueny iaia?aiinoaa?e?coth/ith ae??th I?EA (N.A.Oi?eue, 1994). Aeinoia??ii? ??cieoe? i?ae aeuaia?a?aoiaaieie iieacieeaie a ae?oae ??? oa ?? a?oi ia niinoa??aaeinue (P>0.05), oi/a a ??? a?oi? aiie noaee
aeeae/eie aei ii?ie ? aeinoia??ii ia a?ae??ciyeeny a?ae cia/aiue o
eiio?ieuei?e a?oi? (P>0.05).

Uiaei aeeiai?ee iieaciee?a NA? – INI, oi a ae?oae ia?oi? a?oie i?ae
aieeaii aaciaiai e?eoaaiiy CAeA niinoa??aaeiny ciaioaiiy (P<0.05) INI1, ? eeoa oaiaeaioe?y aei ciaioaiiy INI2 (P>0.05), oaeiae iacia/ii
ciaioeany A?A? (P>0.05).

O ?? oa ??? a?oiao niinoa??aaeiny aeinoia??ia cieaeaiiy oeeo o?ueio
iieaciee?a (P<0.05), ui iiynith?oueny oei, ui I?EA oa oieioa?iea aoeaoao noeioeththoue i?ioeane oeaieiiiai aeeoaiiy, ciaioothoue aai?/io a?iien?th, noaa?e?cothoue ee?oeii? iaia?aie. Oaeei /eiii, aeeth/aiiy *IEIE oa a?oai?io A a eiiieaenia e?eoaaiiy CAeA ni?ey? iie?auaiith ee?i?/iiai ia?aa?ao caoai?thaaiiy, ?noioiiio i?e?inoo aaiiaeia?io, ne?iaaoeiaiai cae?ca, noaa?e?caoe?? aeoeaiino? oa ciaioaiith aeao?oeeoo a O-ee?oeii?e eaioe? ?ioi?oaoo c a?aeiiaeaiiyi caeaoiino? ?ioiieiiiaoaioieo ee?oei aei aeic??aaiiy oa aeeoa?aioe?aoe??, a oaeiae noaa?e?caoe?? ee?oeiieo iaia?ai, iineeaiith aeoeaiino? AINC, ?noioiiio cieaeaiith ia?ea??a aiaeiaaiii? ?ioieneeaoe??. Aeniiaee 1. Cae?ciaeao?oeeoi? aiai?? o ae?oae aeioe?eueiiai oa oe?eueiiai a?eo aeieeathoue aiane?aeie ii?aeiaiiai aieeao ?yaeo oaeoi??a, na?aae yeeo i?ia?aeia ?ieue iaeaaeeoue aeaoaeoai aeaiaeiaoaaiiy ia ia?oiio ?ioe? aeeooy (63.47%) oa iacaaeainiaaiiio oa?/oaaiith a iiaeaeueoiio, a oaeiae aino??e ? o?ii?/i?e ?ioaeoe?ei?e iaoieia?? (61.08%). 2. O ee?i?/i?e ea?oei? CAeA na?aaeiueiai oa oyaeeiai nooiai?a ia?aaaaeathoue neiae?iie: aiaeiaaiii? ?ioieneeaoe?? (66.46%), neaea?iiai?/iee (64.67%), na?oeaai-noaeeiiee (43.11%). 3. Ae?aaeai?noue ee?i?/ieo ? ia?aee?i?/ieo i?iya?a CAeA ciaoiaeeoueny o i?yi?e caeaaeiino? a?ae oyaeeino? ? o?eaaeino? CAeA, ia?aa?a yei? o 73.64% ianoaaeaieo ae?oae iaaoaaa o?ii?/iiai oa?aeoa?o, iayaiino? noiooiuei? iaoieia??, yea ?icaeaa?oueny ia oii? aeao?oeeoo cae?ca (53.29%) aai ia?aaeo? eiai iiya? (46.71%). 4. Ia oe? aeao?oeeoo cae?ca a i?aai?ci? aeeoeie i?aeaeuo?oueny aeoeai?noue i?ioean?a ia?ieneaeaoe??, ui i?aeoaa?aeaeo?oueny aeinoia??iei ca?eueoaiiyi iaeiiiaiai aeeaeueaeaa?aeo, cieaeaiiyi ai?noo aioeieneaeaioieo oa?iaio?a noia?ieneaeaeeniooace ? eaoaeace, eiiiainaoi?iei i?aeaeuaiiyi oea?oeiieaci?io, ui a naith /a?ao ni?ey? oi?ioaaiith neiae?iio aiaeiaaiii? ?ioieneeaoe?? (66.46%), a?io?i?/iei ia?ea?ii yeiai ? i?aeaeuaiee ??aaiue iieaeoe na?aaeiuei? iane a a?eo?ioeeoao ? ca?eueoaiiy a?eo?ioeeoa?iiai ?iaeaeno aiaeiaaiii? ?ioieneeaoe??. 5. I?e cae?ciaeao?oeeoi?e aiai?? aeieeathoue ci?ie a ?ioiieia?/iiio noaoon?, ye? i?iyaeythoueny cieaeaiiyi caaaeueii? e?eueeino? oa ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a, i?aeaeuaiiyi iaaeeoa?aioe?eiaaieo I-ee?oei, ii?ooaiiyi ni?aa?aeiioaiiy ?ioii?aaoeyoi?ieo O-e?ioioeeo?a, cieaeaiiyi ??aiy Ig G oa Ig A, i?aeaeuaiiyi ??aiy Ig I. Iane?aeeii oeeo ci?i ? i?aeaeuaia noeeuei?noue ae?oae, oai?eo ia CAeA, aei ?io?eoaaiiy ? oi?ioaaiiy o?ii?/ieo aiaieu ?ioaeoe??. 6. Canoinoaaiiy eiiieaeniiai e?eoaaiiy CAeA c aeeth/aiiyi /a?acoe??ii? iaai?oieaca?ioa?ai?? oa a?oai?io A ii?yae ?c o?aaeeoe?eiith oa?ai??th (i?aia?aoe cae?ca, a?oai?i N, oa?iaioe) ni?ey? a?eueo oaeaee?e iiceoeai?e aeeiai?oe? ee?i?/ieo neiioii?a, e?euee?nieo oa ye?nieo iieaciee?a /a?aiii? e?ia?, ii?iae?caoe?? i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a ? ai?noo iieaeoe na?aaeiuei? iane, a oaeiae a?aeiiaeaiith ooieoe?iiaeueii? aeoeaiino? oa ciaioaiith aeao?oeeoo a O-eaioe? ?ioi?oaoo. I?aeoe/i? ?aeiiaiaeaoe?? 1. I?iiiio?oueny aecia/aiiy na?aae ae?oae 3-14 ?ie?a a?oi ?eceeo c ?icaeoeo cae?ciaeao?oeeoii? aiai??: ae?oe c aeaoaeoaie aeaiaeiaoaaiiy ia ia?oiio ?ioe? aeeooy ? o?, ye? a iiaeaeueoiio ciaoiaeeeeny ia iacaaeainiaaiiio oa?/oaaii?; /anoi oai??th/?; c o?ii?/ieie aiaieuaie ?ioaeoe??. Aeacai? a?oie ae?oae ia ??aeoa aeaio ?ac?a ia ??e iiaeii? ianoaaeoaaoenue ia iayai?noue cae?ciaeao?oeeoii? aiai??. 2. C iaoith ioe?iee aeeaeie iaoaaie?/ieo ii?ooaiue, i?io?eaeoeee ?ioaeoe?eieo caoai?thaaiue ? aeey ?ic?iaee iaoiaaiaoe/ii iaa?oioiaaiiai ?iaeea?aeoaeueiiai e?eoaaiiy i?iiiio?oueny aeine?aeaeaiiy iieaciee?a ?ioiia?aie, aiaeiaaiii? ?ioieneeaoe?? (iieaeoee na?aaeiuei? iane, a?eo?ioeeoa?iee ?iaeaen aiaeiaaiii? ?ioieneeaoe??), e?iiia?ieneaeaoe?? (iaeiiiaee aeeaeueaeaa?ae), oa?iaio?a aioeieneaeaioiiai caoenoo (noia?ieneaeaeeniooaca, eaoaeaca, oea?oeiieaci?i). 3. E?eoaaiiy ae?oae, oai?eo ia cae?ciaeao?oeeoio aiai?th, iiaeiii aooe eiiieaeniei ?c a?aooaaiiyi i?e/eie aeao?oeeoo cae?ca, oiiiai? iaoieia??, iaoaaie?/ieo ii?ooaiue. 4. C iaoith i?aeaeuaiiy aoaeoeaiino? oa?ai?? aeaieo oai?eo ?aeiiaiaeo?oueny a ii?aeiaii? c o?aaeeoe?eiith oa?ai??th canoinoaaiiy /a?acoe??ii? iaai?oieaca?ioa?ai?? ? a?oai?io A. *a?acoe??ia iaai?oieaca?ia ii?ii?iaiiy e?ia? i?iaiaeeoueny ia i?iaeoe?th eoa?oaeueii? aaie eaca?iith onoaiiaeith iai?ai?ia?aeieeiaiai oeio, ui aeeo/a? ?io?a/a?aiiee i?ii?iue a aacia?a?aiiio ?aaeei? ?iaioe, ? iaai?oiith ianaaeeith iiooaei?noth 25 iAo. O?eaae?noue naain?a a?ae 5 aei10 oaeeei o caeaaeiino? a?ae a?eo aeeoeie. Eo?n e?eoaaiiy neeaaea?oueny c 7-8 i?ioeaaeo?. A?oai?i A aea?oueny a aeic? 2 ia/ea/aeiao a iaeei i?eeii i?ioyaii 14 aei?a. Nienie iioae?eiaaieo ?ia?o  Aeaye? aniaeoe ee?i?/iiai ia?aa?ao cae?ciaeao?oeeoieo aiai?e o ae?oae // IAA.–1997.–?3.–N.33-34.  Cia/aiiy a?eo?ioeeoa?ieo ?iaeaen?a aeey ae?aaiinoeee cae?ciaeao?oeeoieo aiai?e o ae?oae // Aano. i?iaeai aeie. e iaae.– 1997.–?9.–N.86-87 (ni?aaao. Eooeee A.A.).  Aeaye? iieacieee iai?io cae?ca o ae?oae i?e cae?ciaeao?oeeoi?e aiai?? // Oe?. iaoe.-iaae. iieiae?ae. aeo?i.–1997.–?4.–N.49–51.  E?eoa??? ae?aaiinoeee aiaeiaaiii? ?ioieneeaoe?? i?e cae?ciaeao?oeeoi?e aiai?? o ae?oae // IAA.–1998.–?2.–N.19-20 (ni?aaao. Ni?yi ?.N.).  Canoinoaaiiy iaai?oieaca?ioa?ai?? o eiiieaeniiio e?eoaaii? ae?oae, oai?eo ia cae?ciaeao?oeeoio aiai?th // A?niee iaoeiaeo aeine?aeaeaiue.– 1999.– ?2.– N.62-64.  Ee?i?ei-noaoenoe/ia oa?aeoa?enoeea ae?oae ?c aeao?oeeoieie aiai?yie e aoaeoeai?noue ?o ?aaa?e?oaoe?? // Iaoa??aee ieaioio iaoe.-iaae. oiaa?enoaa aeeoy/eo e?ea??a: ?aaa?e?oaoe?y a iaae?ao???.– Ee?a–Oa?iii?eue, 1995.– N.111-112 (ni?aaao. Oiaei?/oe I.ss.)  Ee?i?ei-?ioiieia?/i? ci?ie i?e cae?ciaeao?oeeoieo aiai?yo o ae?oae // Iaoa??aee OL iaoe. eiio.: Caeiaooee ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie.– Oa?iii?eue, 7 o?aaiy 1997.–N.484-486.  Iaaeeei-nioe?aeuei? i?iaeaie cae?ciaeao?oeeoieo aiai?e o ae?oae // Iaoa??aee XLI iaoe. eiio.: Caeiaooee ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie.– Oa?iii?eue, 9 /a?aiy 1998.– N.356-360.  Iniaeeaino? ooieoe?iiaeueiiai noaio o?aaiiai eaiaeo o ae?oae ?c cae?ciaeao?oeeoieie aiai?yie // Oace aeiiia. I?aeia?. eiio.: Aeooaeuei? ieoaiiy ii?oieia??. Oa?iii?eue, 6–8 o?aaiy 1996.– N.721.  Iniaeeaino? ia?aa?ao ? aoaeoeai?noue e?eoaaiiy cae?ciaeao?oeeoieo aiai?e o ae?oae // Oace aeii. XXXIX iaoe. eiio. nooae. ? iieiaeeo a/aieo. Oa?iii?eue, 1996.– N.93-95.  Ae?aaiinoeea cae?ciaeao?oeeoieo aiai?e c aeei?enoaiiyi aeaieo aaoiiaoe/iiai aiae?co e?ia? // Oace aeiiia. ? I?aeia?. iaae. eiia?ano nooae. ? iieiae. a/aieo.– Oa?iii?eue, 18–22 o?aaiy 1997.– N.105-106 (ni?aaao. Eooeee A.A.).  Ia?aeenia ieeneaiiy e?i?ae?a ? aeoeai?noue aioeieneaeaioieo oa?iaio?a i?e cae?ciaeao?oeeoieo aiai?yo o ae?oae // Oace aeiiia. iaoe. eiio.: No/ani? i?iaeaie aaiaoieia?? oa o?ainooc?ieia??. Ee?a, 31 aa?aciy 1998.–N.31.  Aieea aeao?oeeoo cae?ca ia ooieoe?iiaeueiee noai na?oeaai-noaeeiii? nenoaie o ae?oae // I?iae. aeieia?? oa iaaeeoeeie.– 1998.–?3–4.–N.66.  Aei ieoaiiy ao?ieia?? oa iaoiaaiaco cae?ciaeao?oeeoieo aiai?e o ae?oae // Oace aeiiia. ?? I?aeia?. iaae eiia?ano nooae. ? iieiaeeo a/aieo.– Oa?iii?eue, 6–8 o?aaiy 1998.–N.196-197.  ?ieue oa?/oaaiiy a ?icaeoeo cae?ciaeao?oeeoieo aiai?e o ae?oae 3–14 ?ie?a // Oace aeiiia. ?? eiio. Anioe?aoe?? aeeoy/eo e?ea??a Oe?a?ie: E?eoaaeueii-i?io?eaeoe/ia oa?/oaaiiy oa i?ia?ioeee a iaae?ao???.– Ee?a, 1–3 /a?aiy 1998.–N.41-42. AIIOAOe?ss Ua?aaothe Iaoae?y TH???aia. “Ee?i?/i? oa ia?aee?i?/i? i?iyae cae?ciaeao?oeeoii? aiai?? o ae?oae ? iaoiaee ?o ei?aeoe??”. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.10 – iaae?ao??y. ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, Ee?a, 1999?., ?oeiien. Aeena?oaoe?y i?enay/aia aea/aiith iniaeeainoae ee?i?/ieo i?iya?a, iieaciee?a ia?eoa?e/ii? /a?aiii? e?ia?, cae?ca ne?iaaoee, caaaeueii? cae?cica’ycoth/i? caeaoiino? e?ia?, eiao?oe??ioa iane/aiiy o?ainoa?eia, ?ioi?oaoo, ia?aeeniiai ieeneaiiy e?i?ae?a, aiaeiaaiii? ?ioieneeaoe?? o ae?oae 3-14 ?ie?a, oai?eo ia CAeA, o caeaaeiino? a?ae a?eo, nooiaiy oyaeeino?, o?eaaeino? caoai?thaaiiy, noiooiuei? iaoieia??. Ia iniia? ee?i?ei-eaai?aoi?iiai ianoaaeaiiy iaoiaaiaoe/ii iaa?oioiaaii ?icaeoie neiae?iio aiaeiaaiii? ?ioieneeaoe?? i?e CAeA na?aaeiueiai oa oyaeeiai nooiai?a ? iieacaii eiai aieea ia aeeiai?eo caoai?thaaiiy. Aeyaeaii ae?aaeaiee aoaeo a?ae ii?aeiaiiai canoinoaaiiy iaai?oieaca?ioa?ai?? ? a?oai?io A a eiiieaeniiio e?eoaaii? ae?oae, oai?eo ia CAeA. Eeth/ia? neiaa: cae?ciaeao?oeeoia aiai?y, aiaeiaaiia ?ioieneeaoe?y, ia?aeenia ieeneaiiy e?i?ae?a, iaai?oieaca?ioa?ai?y. AIIIOAOeEss Ua?aaothe I.TH. “Eeeie/aneea e ia?aeeeie/aneea i?iyaeaiey aeaeaciaeaoeoeeoiie aiaiee o aeaoae e iaoiaeu eo ei??aeoeee”. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 – iaaeeao?ey. Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee AII Oe?aeiu, Eeaa, 1999a., ?oeiienue. Aeenna?oaoeey iinayuaia eco/aieth iniaaiiinoae eeeie/aneeo i?iyaeaiee, iieacaoaeae ia?eoa?e/aneie e?aniie e?iae, nuai?ioi/iiai aeaeaca (NAE), iauae aeaeacinaycuaathuae niiniaiinoe nuai?ioee (IAENN), eiyooeoeeaioa ianuuaiey o?ainoa?eia (EIO), eiioieoaoa, ia?aeeniiai ieeneaiey eeieaeia, yiaeiaaiiie eioieneeaoeee o aeaoae 3-14 eao, aieueiuo aeaeaciaeaoeoeeoiie aiaieae (AEAeA), a caaeneiinoe io aic?anoa, noaiaie oyaeanoe, i?iaeieaeeoaeueiinoe caaieaaaiey, oiiiaie iaoieiaee. N yoie oeaeueth auei ianeaaeiaaii 167 aieueiuo e 20 caei?iauo aeaoae a aic?anoa io 3 aei 14 eao. Aeeaaiic AEAeA aunoaaeyeny ia iniiaa ?aeiiaiaeaoeee AIIC. Ana aeaoe auee ?acaeaeaiu ia o?e a?oiiu a caaeneiinoe io oyaeanoe caaieaaaiey. O iaeue/eeia AEAeA /aua ano?a/aeanue a aic?anoa 3-5 eao, a o aeaai/ae – a 6-14 eao. Aicieeiiaaieth aeaoeoeeoa aeaeaca niinianoaiaae ?yae oaeoi?ia, n?aaee eioi?uo aeaaiay ?ieue ioaiaeeeanue aeaoaeoai anea?ieeaaiey ia ia?aii aiaeo aeecie, ianaaeaine?iaaiiiio ieoaieth a iineaaeothuai, a oaeaea ino?ie e o?iie/aneie eioaeoeeiiiie iaoieiaee. A eeeie/aneie ea?oeia caaieaaaiey auee auaeaeaiu neaaeothuea neiae?iiu: yiaeiaaiiie eioieneeaoeee, neaea?iiaie/aneee, na?aea/ii-ninoaeenoue. *anoioa e au?aaeaiiinoue eeeie/aneeo neiae?iiia caaenaea io oyaeanoe e i?iaeieaeeoaeueiinoe caaieaaaiey, oa?aeoa?a niioonoaothuae iaoieiaee. Iaeaieaa /anoi ano?a/aaiui aue neiae?ii yiaeiaaiiie eioieneeaoeee – o 66.46% aeaoae n aoi?ie e o?aoueae noaiaiueth AEAeA. Eeeie/aneea i?eciaee neiae?iia auee iieeii?oiuie e eiaee ianiaoeeoe/aneee oa?aeoa?. Ea?oeia ia?eoa?e/aneie e?aniie e?iae aieueiuo AEAeA aeaoae oa?aeoa?eciaaeenue iaee/eai i?eciaeia aeiio?iiiie iee?ioeeoa?iie aiaiee. Ii ia?a ia?inoaiey aeaoeoeeoa aeaeaca oiaiueoaeny n?aaeiee iauai y?eo?ioeeoa, n?aaeiaa niaea?aeaiea e n?aaeiyy eiioeaio?aoeey aaiiaeiaeia a y?eo?ioeeoa. Ioia/aeinue oaaee/aiea a 1.5 ?aca ii n?aaiaieth n eiio?ieueiie a?oiiie eiaeaena ?ani?aaeaeaiey y?eo?ioeeoia. I?e/ai o 9.6% aeaoae aai eciaiaiey eiaee ianoi i?e aua ii?iaeueiii n?aaeiai iauaia y?eo?ioeeoia, /oi aeaao i?aai n/eoaoue aai ?aiiei /oanoaeoaeueiui iieacaoaeai aeaoeoeeoa aeaeaca. Oa?aeoa? y?eo?ioeeoa?iie aenoia?aiiu caaenae io noaiaie oyaeanoe caaieaaaiey. Iia eiaea oe?ieia iniiaaiea e auea naeaeiooa aeaai. I?e III noaiaie AEAeA aenoia?aiia auea aeaoai?aie, /oi oeacuaaei ia iaee/ea aeaoo noaiiioeyoeee y?eo?ioeeoia: iee?ioeeoia e iae?ioeeoia. O?iaaiue NAE e?iae i?e oyaeaeie noaiaie aue a 2 ?aca iaiueoa, /ai o aeaoae eiio?ieueiie a?oiiu. Ia?aeeaeueii nieaeaieth NAE oiaiueoaeny EIO, e iiauoaeanue IAENN. Aiaeec ?acoeueoaoia eiioiieiae/aneeo enneaaeiaaiee auyaee aeaoeoeeo O-nenoaiu eiioieoaoa, ?ino iaaeeooa?aioee?iaaiiuo ioeaauo eeaoie, nieaeaiea eiee/anoaa eiioii?aaoeyoi?iuo noaiiioeyoeee, eiioeaio?aoeee eiioiiaeiaoeeiia G e A, iiauoaiea o?iaiy eiioiiaeiaoeeia I. Ioia/aeinue iiauoaiea iaeiiiaiai aeeaeueaeaaeaea – iieacaoaey oneeaiey ia?aeeniiai ieeneaiey eeieaeia (IIE) e nieaeaiea aeoeaiinoe oa?iaioia aioeieeneeoaeueiie caueou: noia?ieneaeaeeniooacu e eaoaeacu, iiauoaiea oea?oeiieacieia. Ia iniiaa eeeieei-eaai?aoi?iuo enneaaeiaaiee auei iaoiaaiaoe/anee iainiiaaii ?acaeoea neiae?iia yiaeiaaiiie eioieneeaoeee i?e AEAeA ?? e ??? noaiaie, aeieacaoaeuenoaii iaee/ey eioi?iai auei iiauoaiea iieaeoe n?aaeiae iannu (INI) o ianeaaeiaaiiuo aeaoae n iaeneiaeueiie au?aaeaiiinoueth i?e III noaiaie AEAeA. Aiaeiae/iua eciaiaiey auee onoaiiaeaiu aeey y?eo?ioeeoa?iiai eiaeaena yiaeiaaiiie eioieneeaoeee (YEYE). Onoaiiaeai au?aaeaiiue yooaeo aneaaenoaea ni/aoaiiiai i?eiaiaiey iaaieoieaca?ioa?aiee e aeoaieia A a eiiieaeniii ea/aiee aeaoae, aieueiuo AEAeA. I?e yoii i?e?ino aaiiaeiaeia aue a 1.5-2 ?aca auoa, /ai o aeaoae, eioi?ua iieo/aee eneeth/eoaeueii i?aia?aou aeaeaca. Yoi aeaao aiciiaeiinoue nie?aoeoue iineaaeothuee i?eai i?aia?aoia aeaeaca a 1.5-2 ?aca. E?iia yoiai, i?eiaiaiea eiiieaeniiai ea/aiey AEAeA niinianoaiaaei aieaa auno?ie iieiaeeoaeueiie aeeiaieea eeeie/aneeo i?iyaeaiee caaieaaaiey, iiauoaieth o?iaiy NAE, nieaeaieth IAENN, iiauoaieth EIO, oeo/oaieth eiioiieiae/aneie ?aaeoeaiinoe, oiaiueoaieth aeaoeoeeoa iauaai eiee/anoaa O-eeioioeeoia, aiciaiiaeaieth eo ooieoeeiiaeueiie aeoeaiinoe, iiauoaieth o?iaiy eiioii?aaoeyoi?iuo noaiiioeyoeee, ii?iaeecaoeee niaea?aeaiey eiioiiaeiaoeeia G. Oaeaea ioia/ai au?aaeaiiue yooaeo eiiieaeniiai ea/aiey AEAeA a ieaia ii?iaeecaoeee i?ioeannia IIE, oneeaiey aeoeaiinoe oa?iaioia aioeieeneeoaeueiie caueou, oiaiueoaiey o?iaiy INI e YEYE. Eeth/aaua neiaa: aeaeaciaeaoeoeeoiay aiaiey, yiaeiaaiiay eioieneeaoeey, eiioiiay nenoaia, ia?aeeniia ieeneaiea eeieaeia, iaaieoieaca?ioa?aiey. SUMMARY Shcherbatyuk N.J. Clinical and Paraclniical Manifestation of Iron Deficiency Anemia in Children and their Correction Methods. Thesis for a Master’s degree of medicine in Speciality 14.01.10 – pediatrics. The institute for pediatrics, obstetrics and gynecology of Ukrainian AMS, Kyiv, 1999. Manuscript. The thesis deals with the study of clinical manifestations peculiarities, peripheral red blood findings, iron serum, general iron combining capability, transferin saturation index, immunity, lipid peroxidation, endogenic intoxication in children 3-14 years of age with iron deficiency anemia depending on age, severity state, the disease duration and associated pathology. Endogenic intoxication syndrome development in mild and moderate iron deficiency anemia in pathogenically substantiated on the basis of clinical and laboratory investigation, its influence upon the disease dynamics being demonstrated. There has been achieved a pronounced effect due to a combined usage of the magneto-lazer therapy and vitamin E in complex treating children with deficiency anemia. Key words: iron deficiency anemia, endogenic intoxication, immune system, lipid peroxidation, magneto-lazer therapy.

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