21

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo

ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia

?i. E.A.A?iiaoaanueeiai

I?IEII?A

Ieaenaiae?a Aieiaeeie??aia

OAeE: 616.981.49–053.3–092.19–037

Ee?i?/ia ? i?iaiinoe/ia cia/aiiy ?iceaae?a eieaeueiiai ?ioi?oaoo

i?e naeueiiiaeueic? o ae?oae ?aiiueiai a?eo

oa iiaeeeaino? ?o ei?aeoe??

14.01.13 – ?ioaeoe?ei? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe?y ? ?oeiien

?iaioa aeeiiaia a Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i. Aeaieea Aaeeoeueeiai IIC Oe?a?ie.

Iaoeiaee ea??aiee:aeieoi? iaaee/ieo iaoe, i?ioani?

E?aia??a Na?a?e Ieaenaiae?iae/,

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. aeaae. I.I.Aiaiiieueoey IIC Oe?a?ie,

caa. eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia

Io?oe?ei? iiiiaioe:aeieoi? iaaee/ieo iaoe, i?ioani?

*a?ieoiaa Ethaeieea ?aai?aia,

Ee?anueea aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooeeieea IIC
Oe?a?ie,

caa. eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia

Caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,

aeieoi? iaaee/ieo iaoe, i?ioani?

Ieoaeeiaa Aca Ieoaee?aia,

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie,

caa. eaoaae?e aeeoy/eo ?ioaeoe?eieo oai?ia

I?ia?aeia onoaiiaa:

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

Caoeno a?aeaoaeaoueny «27» n?/iy 2000 ?. ia 11 aiae. ia can?aeaii?
Niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01 i?e Ee?anueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ii.
E.A.A?iiaoaanueeiai IIC Oe?a?ie (252150, i.Ee?a, aoe. N?/iaaiai
iianoaiiy, 23).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? EIAe?A?O IIC Oe?a?ie
(252150, i.Ee?a, aoe. N?/iaaiai iianoaiiy, 23).

Aaoi?aoa?ao ?ic?neaiee «25» a?oaeiy 1999 ?.

A/aiee nae?aoa?

Ciaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe
A.Ae.Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oi?iaeiaae inoaiiueiai aeanyoe??//y a Oe?a?i?
iieacieee caoai?thaaiino? ia aino?? eeoeia? ?ioaeoe?? (AE?)
caeeoathoueny aenieeie, oo?eio?oueny /?oea oaiaeaioe?y aei iaaieiiiai
?inoo caoai?thaaiino? ia naeueiiiaeueic (A.I.Ua?a?inueea, 1995;
A.O.Ia???anueeee, 1996; N.I.E?aia??a, 1997, 1998; E.?.*a?ieoiaa,
1998), ui iaaoa cia/iiai iioe?aiiy c na?aaeeie 80-o ?ie?a
(A.I.Ca-?eoeueeee, 1988). A oiiaao no/anieo aeiiii?/ieo oa aeieia?/ieo
iaaa- ?acae?a naeueiiiaeueic iaeiaaacia/i?oee aeey ae?oae ?aiiueiai
a?eo. Aaeaea, e??i iac??eino? iaoai?ci?a ?ioiieia?/iiai caoenoo
oa iania- oeeo?/ii? ?acenoaioiino? i?aai?cio, ui aecia/a? noeeuei?noue
aei caoai-?thaaiiy ae?oae ?aiiueiai a?eo ia naeueiiiaeueic ? cia/io
/anoioo ?ic- aeoeo o ieo oyaeeeo oi?i oai?iae, naia a oeueiio
a?oe? iaea?eueo a?ae/ooiee aieea iaaaoeaieo /eiiee?a aeiae?eey ia
ii??i?noue i?aai?cio (TH.A.Aa?ooaei, 1996,1998). Ianieyoeea? aeieia?/i?
/eiieee co- iiaeththoue nooo?a? ?iceaaee caaaeueiiai oa i?noeaaiai
?ioi?oaoo (TH.A.Aaeueoeuaa, A.A.Oienaaa, 1992), ?icaeoie
?ioiiaeao?oeeoieo noai?a (A.Ae?aii?e, 1996), ii?ooaiiy ooieoe??
a?noiaaiaoe/ieo aa?’???a (TH.A.Aa?ooaei c? ni?aaao., 1995). Ca oaeeo
ia?aaeoiia /anoioa oyae- eeo oi?i naeueiiiaeueico c ?icaeoeii
a?iiaieai?/iiai oieo ca?eueoo- ?oueny ia eeoa o ae?oae, aea e o
aei?ineeo (AE.E.Aiceaiiaa, A.E.E?aa- /aiei, 1990), cia/iiai iioe?aiiy
iaaoaathoue anioe?eiaai? oi?ie oai- ?iae, neeaaeiaeie yeeo ?
oiiaii-iaoiaaii? aaeoa???, iineeth?oueny ?ecee iicaeeoeiai?
o?aineieaoe?? caoaeiee?a oai?iae ? ?icaeoeo ?ioaeoe?eii-oiene/iiai
oieo.

Oni?o e?eoaaiiy naeueiiiaeueico aaeeeith i??ith aecia/a?oueny
nai?/aniith ?iaeoeaaoe??th oiene/ieo noanoaioe?e caoaeieea oai?iae, ui
caii/aoeiaothoue ye i?noeaa? ci?ie ia ??ai? neeciai? iaieiiee eeoie,
oae ? caaaeuei?, iiina?aaeeiaai? a?ieia?/ii aeoeaieie ?a/iaeiaie
(N.A.E?aia?aa, 1991). Aeioe?euei?noue ca’ycoaaiiy oienei?a aaciina?aae-
iuei a i?ina?o? eeoie, ye i?e naeueiiiaeueic?, oae ? ?ioeo AE?,
aacia?a- /ia. C oe??th iaoith i?e AE? a inoaii? ?iee oni?oii
canoiniaothoueny aioa?ini?aaioe, ye o aei?ineeo (I.A.Aiae?ae/ei c?
ni?aaao., 1991, 1992, 1998; A.A.Aaaao c? ni?aaao., 1992, 1997;
E.A.I?eiea?aa, 1993), oae ? ae?oae (A.?.Iinothe c? ni?aaao.,
1988, 1991; E.A.Aieyinueea, 1998; ?.E.Ai??oiy, 1998, 1999).

Ine?eueee i?e naeueiiiaeueic? i?noeai aaciina?aaeiueiai eiioaeoo c
canoiniaaiei aioa?ini?aaioii ? o?aaeai? eeoee, aea cina?aaeaeaii
aeecueei iieiaeie e?ioi?aeii? oeaieie i?aai?cio, caneoaiao? ia oaaao
aea/aiiy aieeao i?aia?aoo ia iaoai?cie eieaeueiiai ?ioiieia?/iiai
caoenoo. Aaeaea i?e aacia?a/iino? aca?iica’yceo an?o eaiie ?ioiii?
nenoaie aeania i?e AE? noaiii eieaeueiiai ?ioi?oaoo cia/iith i??ith
aecia/a?oueny ?icaeoie ? ia?aa?a oai?iae. Eieae?ciaai? a i?aeai?oa-
e?aeueieo i?inoi?ao neeciai? iaieiiee eeoie O-e?ioioeeoe (Mc. Der-
mott R.P., 1986) i?ae aieeaii aioeaaiieo iiae?aciee?a ?iaeoeothoue nei-
oac iiiiia?ieo ?ioiiaeiaoe?i?a, aieiaiei /eiii IgA, a ieaciaoe/-
ieo ee?oeiao neeciai? iaieiiee eeoie, a ai?oae?aeueieo ee?oeiao yei?
neioaco?oueny a?eueiee nae?aoi?iee eiiiiiaio (ANE), iaiao?aeiee aeey
iaaeaiiy no?eeino? aei ae?? i?ioaie?oe/ieo oa?iaio?a eeoeiaiai ai?noo
aeeia?iiio nae?aoi?iiio ?ioiiaeiaoe?io A (SIgA). E??i oiai, i?e
naeueiiiaeueic? aei ?aae?caoe?? ?io?eoaaiiy oa ?icaeoeo ??cieo ??ai?a
?i-oaeoe?eiiai i?ioeano aaciina?aaeiuei i?e/aoi? iaeo?io?ee (A.O.Aeth-
aa? n niaao., 1975), ui ia?oeie i?a?othoue a ciio o?aaeaiiy i?e
i?i?iaeueieo ?iceaaeao eieaeueiiai aiiainoaco. Ioaea, ?ioiieia?/iee
caoeno oa oeeoii?ioaeoeaia ni?iiiaei?noue neeciai? iaieiiee eeoie
i?e naeueiiiaeueic? caaacia/o?oueny, ianaiia?aae, SIgA oa oaaioeeoa?-
iith nenoaiith caoenoo iaeo?io?e?a. I?e aiae?c? aeaieo e?oa?aoo?e c
ieoaiue ?iceaae?a ?ioiieia?/iiai aiiainoaco o oai?eo ia
naeueiiiaeueic i?eaa?oa? oaaao cia/ia i?aaaethaaiiy iaoeiaeo
aeine?aeaeaiue, ui aa- cothoueny ia aea/aii? nenoaiiiai ?ioi?oaoo. Ca
iayaiino? /eneaiieo ioae?eaoe?e uiaei aoaeoeaiino? aioa?ini?aoe?? i?e
AE?, aeeth/ath/e naeueiiiaeueic, caeeoathoueny ia aea/aieie iaoai?cie
aieeao aioa?i-ni?aaio?a ia eieaeueiee ?ioi?oao oa oeeoii?ioaeoeaio
ni?iiiaei?noue neeciai? iaieiiee eeoie. Aeuaaeeeaaeai? aeai? aecia/eee
iaoo ? ca- aaeaiiy aeaiiai aeine?aeaeaiiy.

Cay’cie ?iaioe c iaoeiaeie i?ia?aiaie. Aeena?oaoe?eia ?iaioa ?
o?aaiaioii eiiieaenii? iaoeiai-aeine?aeii? ?iaioe eaoaae?e aeeoy/eo
?ioaeoe?eieo oai?ia Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
«?ic?iaea iiaeo iaoiae?a e?eoaaiiy aino?eo eeoeiaeo ?ioaeoe?e oa
a??onieo aaiaoeo?a o ae?oae ia iniia? aea/aiiy e?ea?nueeeo i?aia?ao?a
aoa?aioii? ei?aeoe?? ii?ooaiiai aiiainoaco oa iiaeoeyoe??
?ioiii? a?aeiia?ae?» (? Aea?ae?a?no?o 0195V009808).

Iaoa ?iaioe: aea/eoe aieea ?iceaaeia eieaeueiiai iioiioaoo oa
oee-oii?ioaeoeaii? ni?iiiaeiinoi neeciai? iaieiiee eeoie ia ia?aaia
naeueiiiaeueico o aeioae ?aiiueiai aieo i iiaeeeainoue ?o ei?aeoei?
canoi-noaaiiyi a eiiieaeniiio eieoaaiii aioa?ini?aaioa neeea?aea-I.

Iniiaii caaaeaiiy ?iaioe:

1. Aea/eoe iniaeeainoi eeiii/iiai ia?aaiao naeueiiiaeueico o aeioae
?aiiueiai aieo i aecia/eoe iioi?iaoeaiinoue aiinoo INI a ne?i-
aaooei e?iai ye ia?aeeiii/iiai oanoo iiaeeeaoei? nooiaiy
oieneei-ia-oaaiei/ieo c?ooaiue.

2. C’ynoaaoe aeaoa?iiiiaaiinoue nooiaiy oyaeeinoi oa aa?iaioa ia?aaiao
naeueiiiaeueico noaiii eieaeueiiai oa nenoaiiiai aoii?aeueiiai
iio-iioaoo.

3. Aeineiaeeoe ooieoeiiiaeueiee noai oaaioeeoa?ii? nenoaie caoenoo
iaeo?ioieia, aaciina?aaeiuei i?e/aoieo aei caaacia/aiiy oeeoii?i-
oaeoei? neeciai? iaieiiee eeoie.

4. A aeineiaeaeaiiyo in vitro c’ynoaaoe ianeiaeee aaciina?aaeiuei? aei?
nee- ea?aea-I ia caoaeieee iiiinaeueiiiaeueico oa anioeieiaaieo oi?i
oai?iae, /ooeeainoue ?o aei aioeaiioeeia.

5. Iaa?oiooaaoe aeioeieueiinoue i?iaaaeaiiy aeeoa?aioeieiaaieo aa?iaioia
aioa?ini?aoei? neeea?aeii-I i?e ?icieo aa?iaioao ia?aaiao
naeueii-iaeueico.

Iaoeiaa iiaecia io?eiaieo ?acoeueoaoia. Ia iiaenoaai aea/aiiy aiinoo a
eii?ioieueo?aoao SIgA, noieeiai aei aei? i?ioaieioe/ieo oa?- iaioia
eeoeiaiai aiinoo, oa aeineiaeaeaiiy oaaioeeoa?ii? aeoeaiinoi
iaeo?ioieia, ui ia?oeie iia?othoue a ciio o?aaeaiiy i?e iiiiiaeueieo
?iceaaeao eieaeueiiai aiiainoaco, aia?oa aeiaaaeaii aeaoa?iiiiaaiinoue
nooiaiy oyaeeinoi oa aa?iaioa ia?aaiao naeueiiiaeueico o aeioae ?aiiuei-
ai aieo oeeoii?ioaeoeaiith ni?iiiaeiinoth neeciai? iaieiiee
eeoie, ui caaacia/o?oueny, aieiaiei /eiii, iioiiaeiaoeiiaie
iinoeaai? aei? oa oaaioeeoa?iith nenoaiith caoenoo iaeo?ioieia.

Aea/aii eeiiiei-aiiaeaiiieiai/ii iniaeeainoi naeueiiiaeueico oa
ani-oeieiaaieo oi?i oai?iae o aeioae ?aiiueiai aieo. Ca aeaieie
a?aaeaoeieii? ioeiiee iaeaieueo iioi?iaoeaieo aeai?eiaeo eeiii/ieo
neiioiiia naeueiiiaeueico ?ic?iaeaii iioaa?aeueii iieacieee aecia/aiiy
nooiaiy oyaeeinoi oai?iae.

Aecia/aii /eiieee, ui coiiaeththoue iani?eyoeeaee ia?aaia
naeue-iiiaeueico. Ia oyaeeinoue eeiii/ieo oi?i naeueiiiaeueico oa
?icaeoie caoyaeiiai ia?aaiao oai?iae aaeeeith ii?ith aieeaathoue aeai-
oa o?e-eiiiiiaioii aaeoa?ieii anioeiaoei?, neeaaeiaeie yeeo ?
oiiaii-iaoiaaiii aaeoa?i?.

C’yniaaii, ui iioiiaeiaoeiie iinoeaai? aei? ni?eythoue eieaeicaoei?
aino?iai iioanoeiaeueiiai caiaeueiiai i?ioeano i iiia?aaeaeothoue
iica-eeoeiao o?aineieaoeith caoaeieeia iiiinaeueiiiaeueico oa
anioeieiaaieo oi?i oai?iae. Aeaoioeeo SIgA coiiaeth? caoyaeiee ia?aaia
naeueiiia- eueico.

Aeyaeaii aeenaaeain ooieoeiiioaaiiy oaaioeeoa?ii? nenoaie iae-o?ioieia,
ui aiaeaeca?eaeth? oyaeeinoue eeiii/ieo oi?i naeueiiiaeueico
oa i?iaiico? caoyaeiee ia?aaia oai?iae. Na?aae ia?aeeiii/ieo oanoia
iiaeeeaoei? oaaioeeoa?ii? iani?iiiaeiinoi iaeo?ioieia o oai?eo ia
naeueiiiaeueic aeiiiiothoue: eaeeiiaiiy, iaeo?iiaiiy, iecueei iieacieee
O*, cia/ia i noaaieueia cieaeaiiy aiinoo a iaeo?ioieao eaoiiiieo
aieeia.

?iaaiue iieaeoe na?aaeiuei? iane a ne?iaaooei e?iai – /ioeee
ia?a-eeiii/iee oano iiaeeeaoei? nooiaiy oieneei-iaoaaiei/ieo c?ooaiue i
aecia/aiiy oyaeeinoi eeiii/ieo oi?i naeueiiiaeueico, aea i?iaiinoe/-
iiai cia/aiiy uiaei oi?ioaaiiy aa??aioa ia?aaiao oai?iae ia ia?.

Aia?oa ?ic?iaeaii iaoiae aano?iaioa?ieieiiini?aoei? neeea?aeii- I i
aea/aii aaaaoia?aiio eeiii/io aoaeoeaiinoue i?aia?aoo i?e
naeue-iiiaeueic? o aeioae ?aiiueiai aieo. C’yniaaii, ui neeea?ae-I, e?ii
aeaoie-neeaoeieiiai aoaeoo, iiceoeaii aieeaa? ia eieaeueii iaoaiicie
iioii-eiai/iiai caoenoo, ui ?aaeiciaothoueny /a?ac SIgA oa OAI, iiia?a-
aeaeo? iicaeeoeiao o?aineieaoeith caoaeieeia iiiinaeueiiiaeueico
oa anioeieiaaieo oi?i oai?iae, ciaioo? o?eaaeinoue aaeoa?iiaeaeieaiiy.

A aeineiaeaeaiiyo in vitro aeiaaaeaii caeaoi?noue neeea?aea-I iiaeaeuo-
aaoe /ooeea?noue naeueiiiaee oa eeaani?ee (iae/anoioiai iie?iaa-ani-
oeiyioa anioeieiaaieo oi?i oai?iae) aei aioeaiioeeia oa ooi?oiiieiiia,
a?aenooi?noue aaeoa?iioeeaeii? aei? i?aia?aoo noiniaii oeeo aaeoa?ie.
Ciaioaiiy o?eaaeino? aaeoa??iaeae?eaiiy i?e canoinoaaii? a eii-ieaeniiio
e?eoaaii? oai?eo ia naeueiiiaeueic neeea?aea-I iiina?aae- eiaaia
iiceoeaiei aieeaii i?aia?aoo ia eieaeueiee iioiioao oa caeaoiinoth
eiai iiaeaeuoaaoe /ooeeainoue caoaeieeia iiiinaeueiiiaeueico oa
anioeieiaaieo oi?i oai?iae aei aioeaaeoa?ieieo na?aaeieeia.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoaoia. ?ic?iaeaii, ai?i-aiaaii i
cai?iiiiiaaii oaaeeoeth iioaa?aeueieo iieacieeia ioeiiee noo- iaiy
oyaeeinoi eeiii/ieo oi?i naeueiiiaeueico. Ia?aaia naeueiiiaeueico
cia/iith ii?ith iaoyaeothoue aaeoa?ieii anioeiaoei?, neeaaeiaeie yeeo ?
oiiaii-iaoiaaiii aaeoa?i?. Ia?aaeoiiaith ?icaeoeo anioeieiaaieo oi?i
naeueiiiaeueico ? ?iceaaee eieaeueieo iaoaiiciia iioiieiai/iiai caoen-
oo oa ianiaoeeoi/ii? ?acenoaioiinoi i?aaiicio.

Iaa?oioiaaii aeioeieueiinoue aeeiaii/iiai aecia/aiiy aiinoo SIgA a
eii?ioieueo?aoao oa OAI, ye oanoia iiaeeeaoei? ?iceaaeia eieaeueiiai
ai-iainoaco, i?iaiicoaaiiy iani?eyoeeaiai ia?aaiao naeueiiiaeueico oa
ioeiiee aoaeoeaiinoi eieoaaiiy.

Aeey ei?aeoei? ?iceaaeia eieaeueiiai aiiainoaco oa iieiioaiiy
oeeoi-i?ioaeoeaii? ni?iiiaeiinoi neeciai? iaieiiee eeoie ?ic?iaeaii,
ai-?iaiaaii oa cai?iiiiiaaii aeeoa?aioeieiaaii aa?iaioe aioa?ini?aoei?
neeea?aeii-I. Aeey iieiioaiiy naiaoeieiiai aoaeoo aioeaaeoa?ieieo
na?aaeieeia i?e naeueiiiaeueici ?o neiae canoiniaoaaoe iaeii/anii c
i?eeiaiiyi ona?aaeeio neeea?aea-I. O oai?eo ia naeueiiiaeueic, ca
ia-yaiinoi iieacaiue, aeey i?iieaaiiy oeoiea i eeoie aeioeieueii
ei?enoo- aaoeny 0,05-0,1% caaenii neeea?aea-I.

Ai?iaaaeaeaiiy ?acoeueoaoia ?iaioe a i?aeoeeo. ?ic?iaeaii oa ai-?iaiaaii
iaoiaee eieoaaiiy oai?eo ia naeueiiiaeueic c canoinoaaiiyi
aeeoa?aioeieiaaieo iaoiaeia aioa?ini?aoei? neeea?aeii-I aoieaii a
i?aeoeeo iioaeoeieieo eiea?aiue Eueaianueei? oa Aieeinueei? iaeanoae.

?acoeueoaoe i?iaaaeaieo aeineiaeaeaiue aeei?enoiaothoueny a iaa/aeue-
iiio i?ioeani ia eaoaae?i aeeoy/eo iioaeoeieieo oai?ia Eueaianueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ii. Aeaieea Aaeeoeueeiai.

Iaoa?iaee ?iaioe aeeth/aii a iaoiaee/ii ?aeiiaiaeaoei? «Aioa?ini?-aaioe
a eieoaaiii oa i?ioieaeoeoei iioaeoeieieo oai?ia o aeioae» (ooaa-
eaii ?anioaeieainueeei oeaio?ii iaoeiai? iaaee/ii? iioi?iaoei? IIC
Oe?a?ie, 1991 ?.).

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii naiinoieii caeieniaii
aiaeioe/iee iaeyae eioa?aoo?e ? aecia/aii iai?yiie iaoeiaiai
aeine?aeaeaiiy. I?iaaaeaii eeiii/ia ianoaaeaiiy oai?eo, oeieani?yiiaaii
aiioiii/ii, iioiieiai/ii oa niaoeiaeueii aeineiaeaeaiiy, noaoenoe/io ia-
?iaeo ?o /eneiaeo aeii?ia, ocaaaeueiaii ?acoeueoaoe, ?ic?iaeaii oa
ai-?iaiaaii ei?aeoeieii iaoiaee eieoaaiiy, iaa?oioiaaii aeniiaee oa
i?aeoe/ii ?aeiiaiaeaoei?. I?aeaioiaeaii iaoa??aee aeey ioae?eaoe??,
ioi?ieaii aeena?oaoe?th oa aaoi?aoa?ao.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?. Iniiaii iieiaeaiiy ?iaioe
aeeeaaeaii ia XII Oe?a?inueeiio ?anioaeieainueeiio c’?caei iie?iaii-
eiaia, aiiaeaiiieiaia i ia?aceoieiaia (Oa?eia, 1991), neiiicioii
«Iaaee- ei-aiieiai/ii i?iaeaie oiii? iiaa?oii» (Ee?a, 1991),
iiaeia?iaeiie eii-oa?aioei? c i?iaeai iaaeeoeeie eaoano?io (Ee?a, 1992),
IV eiia?ani NOOEO (Oa?eia, 1992), IV c’?cae? iioaeoeiiiinoia Oe?a?ie
(Aiiieoey, 1993), iaoeia?e nan??, i?enay/ai?e 100-??//th eaoaae?e
o?c?ieia?? Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (Euea?a,
1995), V c’?cae? iioaeoeiiiinoia Oe?a?ie (Oa?iiiieue, 1998),
iaoeiai-i?aeoe/iie eiioa- ?aioei? i ieaioii Anioeiaoei?
iioaeoeiiiinoia Oe?a?ie (Eooeuee, 1999), ia- oeiaie eiioa?aioei?
«Canoinoaaiiy a iaaee/iie i?aeoeoei eiea?nueeeo i?aia?aoia (iieini?a,
neeea?ae, neeien, ienee o.i.) ia iniiai aenieiaeen-ia?niiai e?aiiacaio
oa iaoaiicie ?o aei?» (Aiiieoey, 1999).

Ioaeieaoei?. Ca oaiith aeena?oaoei? iioaeieiaaii 19 iaoeiaeo i?aoeue,
c ieo 4 noaooi – a aeo?iaeao, ?aeiiaiaeiaaieo AAE aeey ioaeieaoei?
iaoa?iaeia eaiaeeaeaonueeeo oa aeieoi?nueeeo aeena?oaoeie.

No?oeoo?a ? ianya aeena?oaoe??. Aeena?oaoe?y iiaoaeiaaia ca
caaaeueii-i?eeiyoei ieaiii ? neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iaoa??ae?a oa iaoiae?a aeine?aeaeaiue, o?ueio
?icae?e?a aeanieo aeine?aeaeaiue, aiae?co oa ocaaaeueiaiiy ?acoeueoao?a
aeine?aeaeaiue, aeniiae?a, i?aeoe/- ieo ?aeiiaiaeaoe?e, nieneo
aeei?enoaieo aeaea?ae. ?iaioa aeeeaaeaia ia 144 noi??ieao
iaoeiiieniiai oaenoo (aac o?aooaaiiy a?ae?ia?ao??, ui i?noeoue 336
e?oa?aoo?ieo aeaea?ae), ?ethno?iaaia 21 oaaeeoeath, 4 ia-ethieaie,
aeaiia aeieneaie ?c ?noi??? oai?iae.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiue. Niinoa?aaeaiiy i?iaaaeaii o 146
oai?eo ia naeueiiiaeueic ae?oae ia?oiai ?ieo aeeooy, ye? ciaoiaee-
eeny ia noaoe?iia?iiio e?eoaaii? a ee?i?/i? eioaeoe?ei?e e?ea?i?
i.Eueaiaa. I?e aea/aii? aiaiiaco aeeooy a?aoiaaii noeoii?noue aeaieo,
ui iiaee iaaaoeaii aieeiooe ia i?aii?a?aeio ?aaeoeai?noue i?aai?cio.
Uiaei ai?aeai?ieia?/iiai aiaiiaco aeoeaioiaaii oaaao ia aecia/aii?
nooiaiy a??ia?aeiino? aioo??oiueie?ea?iyiiai ?io?eoaaiiy.

Oyaee?noue caaaeueiiai noaio oai?iai ioe?ithaaee ca ?ioaineai?noth
i?iya?a ?ioieneeaoe?eiiai neiae?iio o ii?aeiaii? c aeeniaine/iei, noo-
iaiai aeneeico, iayai?noth iciae iae?ioieneeico, ?iceaae?a
i?e?ioee?-eoeyoe??, aaiiaeeiai?ee, na?oeaai-noaeeiii? oa aeeoaeueii?
iaaeinoaoiino?.

A aeeiai?oe? oai?iae i?iaiaeeeeny caaaeueiii?eeiyo? eaai?aoi?i?
aeine?aeaeaiiy: aaiia?aia, caaaeueiee aiae?c na/?, eii?ineii?/ia
aeine?-aeaeaiiy aeii?iaeiaiue.

Aeey c’ynoaaiiy ao?ieia?? AE? i?iaiaeeeenue aaeoa??ieia?/i?
aeine?-aeaeaiiy aeii?iaeiaiue, na/?, i?e iio?aa? e e?ia?, ia iaoiaaiio
eeoeiao oei?o, oiiaii- iaoiaaii? aioa?iaaeoa???, noao?eieiee, c
ianooiiei aecia/aiiyi /ooeeaino? aeae?eaieo aaeoa??e aei aioea?ioee?a.

Iaiao?aeiith oiiaith eiinoaoaoe?? ao?ieia?/ii? i?e/aoiino? oiiaii-
iaoiaaiieo aaeoa??e aei anioe?eiaaieo oi?i naeueiiiaeueico aoei ii-
aoi?ia, ia iaioa 2-o ?ac?a, aeae?eaiiy ?o c aeii?iaeiaiue a ia??iae?
iai?oanoaoe?? ee?i?/ieo i?iya?a oai?iae a eiioeaio?aoe?? 106 ? a?eueoa
i?e?ia?a a 1 a.

Ai?no INI a ne?iaaooe? e?ia? aecia/aee aeni?an-iaoiaeii I.?.Aaa-???eyia
c? ni?aaao. (1985) oa aaeue-o?iiaoia?ao?/iei ca E.A.Inoa?ia-
iii (1984).

Aeey aea/aiiy noaio eieaeueiiai ?ioi?oaoo, a eii?io?eueo?aoao, e??i IgA,
IgM oa IgG, aecia/aee ai?no nae?aoi?ieo ?ioiiaeiaoe?i?a A (ia- oiaeii
?ioiiaeeooc?? a aae? ca Iai/?i?). Aeey oieeiaiiy iiaeeeaeo oea- ieo
?acoeueoao?a aecia/aiiy ai?noo SIgA a eii?io?eueo?aoao i?iaiaee-
ee c aeaiia aioene?iaaoeaie: aei IgA oa SIgA. Noai nenoaiiiai
aoii-?aeueiiai ?ioi?oaoo a aeeiai?oe? oai?iae aecia/aee ca ai?noii
iniiaieo eean?a ?ioiiaeiaoe?i?a (I, A, G) a ne?iaaooe? e?ia?.

Aeey ioe?iee iiaeeiaeueii? aeoeaiino? iaeo?io?e?a aecia/aee
oaai-oeeoa?iee ?iaeaen (O?) ? oaaioeeoa?ia /enei (O*) ca aeaieie
iiaeeiaiiy a?aioe eaoaeno. Ieneaeaoe?eii-a?aeiiaio aeoeai?noue
iaeo?io?e?a – ?ioaineai?noue eenaiuecaeaaeiiai iaoaaie?cio, ioe?ithaaee
ca aeaieie oanoo a?aeiiaeaiiy i?o?ineiueiai oao?acie?th
(INO-oanoo). C eiiii- iaio?a ?io?aeaeeioeeoa?ieo i?e?iaioeeaeieo
nenoai, ui ae?thoue ia i?e?ia aac o/ano? eenith, aecia/aee
e?ciniiaeuei? eao?iii? a?eee (EA).

E??i caaaeueiii?eeiyoeo aaeoa??ieia?/ieo aeine?aeaeaiue aeii?iae- iaiue,
na/? oa e?ia?, i?iaiaeeeeny niaoe?aeuei? aaeoa??ieia?/i? aeine?-
aeaeaiiy c iaoith aea/aiiy in vitro aaciina?aaeiueiai aieeao aioa?ini?-
aaioa neeea?aea-I ia caoaeieee AE? (iiaeeea?noue aaeoa??ioeeaeii? ae??)
oa noai /ooeeaino? aei aioea?ioee?a.

Aecia/aiiy iiaeeeai? aaeoa??ioeeaeii? ae?? neeea?aea-I i?iaiaeeee aeaiia
niiniaaie. 1. Aeiaia? eoeueoo?e naeueiiiaee oa eeaan??ee ia?an?aaee
iaeii/anii ia 2 /aoee Iao?? c aeaeoeaiei iiaeeaiei na?a-aeiaeuai,
aeiaaaeyth/e a iaeio c ieo ii 1 ie caaeno neeea?aea-I ??cii?
eiioeaio?aoe??: 0,01%, 0,1% oa 1,0%. Ae?oaa iaeii/anii can?yia /aoea
Iao?? neoaeeea eiio?ieai. ?acoeueoaoe ia?an?a?a ioe?ithaaee i?ney
?ieoaoaaiiy a oa?iinoao? ai?iaeiaae 24-26 aiaeei a?coaeueii. 2. A
/aoee Iao?? c aeiaiaeie eoeueoo?aie naeueiiiaee oa eeaan??ee aeiaaa-
eyee ii 5 ie 0,01%, 0,05%, 0,1%, 0,5% oa 1,0% caaeno neeea?aea-I.
I?ney aeniiceoe?? 30 oa., 4 aiae., 12 ? 24 aiae. c eiaeii? /aoee
Iao?? ii 1 ie cieao, ui i?noea a?aeiia?aei? i?e?iai? eoeueoo?e,
aaeni?aiaai? ia neeea?ae?-I, ia?an?aaee ia oaa?ae? iiaeeai?
na?aaeiaeua. ?acoeueoaoe ioe?ithaaee i?ney ?ieoaoaaiiy a oa?iinoao?
ai?iaeiaae 24-26 aiaeei a?coaeueii.

Aeey aecia/aiiy /ooeeaino? naeueiiiaee oa eeaan??ee aei aioeaae-oa??eieo
na?aaeiee?a canoiniaoaaee iaoiae aeeooc?? a aaa? c aeei?en- oaiiyi
eiia?oe?eieo aeene?a, iane/aieo a?aeiia?aeieie o?i?ii?aia?aoa- ie.
Iiaeeeaee aieea neeea?aea-I ia /ooeea?noue naeueiiiaee oa
eeaan??ee aei aioeaaeoa??eieo na?aaeiee?a aecia/aee ca ?acoeueoaoaie
aeine?aeaeaiue, i?iaaaeaieo ia?aeaeueii c aaeni?aiaaieie ia neeea?ae?-I
i?e?iaieie eoeueoo?aie, iaea?aeaieie aeuaiienaiei niiniaii, oey- oii
ni?anoaaeaiiy c eiio?ieueieie iieacieeaie.

Iaea?aeai? oeeo?ia? aeai? ia?iaeaii iaoiaeii aa??aoe?eii? noaoenoeee
c aecia/aiiyi ianooiieo aaee/ei: na?aaeiueiai a?eoiaoe/iiai (I),
na?aaeiueiai eaaae?aoe/iiai a?aeoeeaiiy (?), noaiaea?oii? iiieeee
na-?aaeiueiai a?eoiaoe/iiai (m), eiao?oe??ioa Nouethaeaioa-O?oa?a (t),
aei-noia??iino? ??cieoe? i?ae na?aaei?ie a?eoiaoe/ieie ?yae?a (?) ca
aeaie- ie oaaeeoeue ?iciiae?eo eiia??iinoae Nouethaeaioa-O?oa?a,
eiao?oe??ioa ei?aeyoe?? (r).

Aeey aioa?ini?aoe?? aeei?enoaii neeea?ae-I – ae??aiiaeenia?niee
e?aiiacai (aeicaieaiee aeey ee?i?/iiai canoinoaaiiy o ae?oae
Oa?iaei-eia?/iei eii?oaoii IIC Oe?a?ie a?aeiia?aeii aei iaeaco ?1 a?ae
28.01.1993 ?.). Oea eaaeee aeaeeoii-a?eoaaoee ii?ioie, aac niaeo;
oa?-iino?eeee, aii?oiee, a?ae?io?eueiee.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Aeai? ai?aeai?ieia?/iiai aiaiiaco aeathoue ciiao aaaaeaoe eiia??iei o
87,7% oai?eo ia naeueiiiaeueic aioo??oiueie?ea?iyia ?io?eoaaiiy
eiioaeoiei oeyoii. I?eaa?oa? oaaao ?icaeoie naeueiiiaeueico ia
ia-oyaeaiiio i?aii?a?aeiiio oii? o 96,6% oai?eo. Ae?aaiic naeueiiiaeuei-
co i?aeoaa?aeaeaii aaeoa??ieia?/ii: aeae?eaiiyi caoaeieea c
aeii?iae- iaiue o 100,0% oai?eo, c? na/? – o 54,1% oai?eo. O
an?o oai?eo aeae?eyeeny naeueiiiaee a?oie A, na?iaa? –
S.typhimurium.

O 49,3% (72 ?c 146) oai?eo ae?aaiinoiaaii anioe?eiaai? oi?ie
naeue-iiiaeueico. O 58 (39,7%) oai?eo niinoa??aaeeny aeaieiiiiiaioi?
aae- oa??ei? anioe?aoe??. C ieo o 27 (46,6%) oai?eo naeueiiiaeueic
ii?aeioaaa- ny c eeaan??eueiciith ?ioaeoe??th, o 16 (27,6%) – c
i?ioaeiith, o 15 (25,8%) – c? noao?eieieiaith. O 14 (9,6%) oai?eo
niinoa??aaeeny o?e-eiiiiiaioi? anioe?eiaai? oi?ie naeueiiiaeueico:
naeueiiiaeueicii-eeaa-n??eueicii-noao?eieieiaa (5 oai?eo),
naeueiiiaeueicii-eeaan??eueicii-i?ioaeia (4),
naeueiiiaeueicii-i?ioaeii-noao?eieieiaa (3) oa
naeueii-iaeueicii-neiueiai?eii-eeaan??eueicia (2 oai?eo).

Ca aeaieie a?aaeaoe?eii? (aaeueii?) ioe?iee iaea?eueo ?ioi?iaoeaieo
aea??eiaeo ee?i?/ieo neiioii?a naeueiiiaeueico, ui niinoa??aaeeny
i?e iinooieaii? oai?eo a noaoe?iia?, ?ic?iaeaii oaaeeoeth aecia/aiiy
?ioaa?aeueieo iieaciee?a nooiaiy oyaeeino? oai?iae (oaae.1). A?aeii-
a?aeii aei oeueiai iieacieea c ianoaaeaieo iaie 146 oai?eo o 112
ae?aaiin-oiaaii na?aaeiueioyaeeo, o 34 – oyaeeo oi?io naeueiiiaeueico.
E??i ioe?iee nooiaiy oyaeeino? naeueiiiaeueico, aaaaeaee ca
aeioe?eueia aeae?-

Oaaeeoey 3.1

A?aaeaoe?eia ioe?iea aea??eiaeo ee?i?/ieo neiioii?a aecia/aiiy
?ioaa?aeueiiai iieacieea nooiaiy oyaeeino? naeueiiiaeueico o ae?oae
ia?oiai ?ieo aeeooy

Ee?i?/i? neiioiieIoe?iea ee?i?/ieo neiioii?a a aaeao1 aae2 aaee3 aaee4
aaee1. Caaaeueiee noaiaeaui ii?ooaieeii?ooaieecia/ii ii?ooaieeiaaeo? c
e?eoe/iei2. Oaiia?aoo?a o?eanoaoaa?eeueia38?N -39?N39,1?N -39,9?N40?N ?
aeua1. noaii?iaeueia3. Aiaoeoaeaui cieaeaieecieaeaieecia/ii
cieaeaieeaii?aen?y4. Noai
i?e?ioee?eoeyoe??ae?ae?noue»ia?io?ia?noue»neiioii «a?ei? ieyie», ae?i-
oa ia??i?aeueiee oe?aiiccaaaeueiee oe?aiic5. Aethaioaiaeii?aciaa3-5
?ac?aa?eueoa 5 ?ac?a»eaaiaa aoua»aeii?oee aeia/?6. Aeii?iae-iaiiy/anoioa

(ia aeiao)aei 5 ?ac?a6-10 ?ac?aa?eueoa ye 10 ?ac?acao?eiea — ia?ac
eeoieoa?aeoa???aee?, aac iaoieia?/ieo aeii?oieneec, i?iaeeeee e?ia?,
caeaiue»aieioia oaaiue», aeii?oee e?ia?eeoeiaa e?iaioa/a7. Nooi?iue
ciaaiaeiaiiyao?aoa iane o?ea ia nooo?aa?-e (5% iane o?ea)??-e (6-9% iane
o?ea)???-e (ao?aoa iane o?ea > 10%)8. Oei
ciaaiaeiaiiy?cioii?/ieeaiaeiaeao?oeeoieenieaaeao?oeeoieeaia?ae?ai?/iee
oie9. Iae?ioieneeicianiie?ecaoaeaeaiiynoaeiiia
aioiai?noueniii?caaaeueiiaai?noue??cea caaaeueiiaai?noueno?ee? noaeiie

Ioe?iea ?acoeueoao?aNoia aae?aOi?ia oai?iaeaei 10 aae?aeaaea a?ae 11 aei
20na?aaeiueioyaeeaa?ae 21 aei 30oyaeeaiiiaae 30 aae?aaeoaea oyaeea,
caa?iceeaee aeey aeeooy noaieeoe oae? aa??aioe ia?aa?ao oai?iae: aino?ee
oeeee?/iee ? caoyaeiee (aacia?a?aiee oa oaeeaiiae?aiee). Aeii?ioth/?
e?eoa??? aino?iai oeeee?/iiai ia?aa?ao naeueiiiaeueico – oaeaeea
iiceoeaia aeeiai?ea ee?i?/ii? neiioiiaoeee i?e /?oe?e iine?aeiaiino?
oaeeo aoai?a oai?i- ae: 1-e – ?ioieneeaoe?eiee neiae?ii, ui
?icaeaa?oueny aino?i aai ia oii? i?ia?niee?a; 2-e – oa?aeoa?iee
aeeniaine/iee neiae?ii, ui ?ic- aeaa?oueny ia oii? caa?aaeaiiy
i?iya?a caaaeueii? ?ioieneeaoe??; 3-e – aeeniaine/iee neiae?ii ca
a?aenooiino? /?oeeo i?iya?a caaaeueii? ?ioie-neeaoe??; 4-e – caeeoeia?
i?iyae aeenooieoe?? eeoie, ui ia iicia/a- thoueny ia caaaeueiiio
noai? oai?iai. Caoyaeiee aacia?a?aiee ia?aa?a naeueiiiaeueico
oa?aeoa?eco?oueny no?ee?noth ee?i?/ieo i?iya?a oai?iae oa?i?iii iiiaae
10 aei?a. I?e oaeeaiiae?aiiio caoyaeiiio ia?aa?ao naeueiiiaeueico
niinoa??aa?oueny ia??iaee/ia a?aeiiaeaiiy aai iineeaiiy ?ioaineaiino?
ee?i?/ii? neiioiiaoeee, coiiaeaia caeaa?eueoiai iaoa-?oaaiiyi
oneeaaeiaiue aai noia??ioaeoe??th.

Aeey aecia/aiiy aca?iica’yceo nooiaiy oyaeeino? ee?i?/ieo oi?i
naeueiiiaeueico oa aa??aio?a ia?aa?ao oai?iae c ia?aee?i?/ieie oanoa-
ie, ui a?aeaeca?eaeththoue nooi?iue oieneei-iaoaaie?/ieo c?ooaiue,
noai eieaeueieo iaoai?ci?a ?ioiieia?/iiai caoenoo oa OAI, ni?aanoaaeaii
cia/aiiy oeeo iieaciee?a a a?oiao oai?eo ia na?aaeiueioyaeeo oa
oyaeeo oi?ie naeueiiiaeueico. I?e oeueiio c’yniaaii ianooiia.

I?aeaeuaiiy ai?noo INI a ne?iaaooe? e?ia? – iaae?eiee e?eoa??e ioe?iee
nooiaiy oyaeeino? ee?i?/ii? oi?ie naeueiiiaeueico oa ?iaeeeaoe??
?ioaineaiino? oieneei-iaoaaie?/ieo c?ooaiue, aea oeae iieaciee ia
iiaea aooe aeei?enoaiee ia ii/aoeiaeo aoaiao caoai?thaaiiy ye oano
i?iaiicoaaiiy aa??aioa ia?aa?ao naeueiiiaeueico (aeo?aei? na?aaei?
ii-eacieee ai?noo INI a ne?iaaooe? e?ia? a iaaeao a?oi oai?eo ia
na-?aaeiueioyaeeo oa oyaeeo oi?ie naeueiiiaeueico ia ??cieeeny caeaaeii
a?ae aa??aioa iiaeaeueoiai ia?aa?ao oai?iae).

Ine?eueee i?e aaeoa??ieia?/ii i?aeoaa?aeaeaieo AE? o ae?oae ?aiiueiai
a?eo ca aeaieie aeine?aeaeaiiy eii?io?eueo?ao?a iaoiaeii ?OA nia-
oeeo?/i? aioeo?ea iaeaaeaoue aei eeano ?ioiiaeiaoe?i?a A
(E.A.Oaeai-aa?eaeca, A.E.Oa/aaa, 1988), ca aeaieie aeeiai?ee ?o ai?noo a
eii-?io?eueo?aoao iiaeia ioe?ieoe ?ioiieia?/io ?aaeoeai?noue i?aai?cio
oa aeaoe ioe?ieo iaaiiio iaoiaeo e?eoaaiiy.

I?e iinooieaii? a noaoe?iia?, a ia??iae? ii/aoeiai? iai?oanoaoe??
ee?i?/ieo i?iya?a oai?iae, o oai?eo ia na?aaeiueioyaeeo oi?io
naeue-iiiaeueico aeyaeaii neio?iiia i?aeaeuaiiy ai?noo a
eii?io?eueo?aoao ye IgA, oae ? S?gA. I?e oyaee?e oi?i?
naeueiiiaeueico noaoenoe/ii a??ia?aeiiai i?aeaeuaiiy ai?noo S?gA a
eii?io?eueo?aoao ia niin- oa??aa?oueny. Oea iiaea aooe coiiaeaii
iaaeinoaoi?i neioacii ai?oae?aeueieie ee?oeiaie cia/ii o?aaeaii? i?e
oyaee?e oi?i? naeue-iiiaeueico neeciai? iaieiiee eeoie neeaaeiai? S?gA –
a?eueiiai nae-?aoi?iiai eiiiiiaioa. A aeeiai?oe? oai?iae i?e aino?iio
oeeee?/iiio ia?aa?ao na?aaeiueioyaeei? oi?ie naeueiiiaeueico ye ia 5-7,
oae ? 10- 14 aei? e?eoaaiiy, ai?no S?gA oa IgA
i?aeaeuo?oueny (o ii??aiyii? c eii-o?ieai oa aeo?aeieie aeaieie). I?e
caoyaeiiio oaeeaiiae?aiiio ia?aa?ao na?aaeiueioyaeei? oi?ie
naeueiiiaeueico i?aeaeuai? ia 5-7 aeaiue e?eoaaiiy na?aaei?
iieacieee ai?noo S?gA oa IgA ia 10-14 aeaiue e?eoaaiiy cieaeothoueny o
ii??aiyii? c iiia?aaei?i aeine?aeaeaiiyi ? ia a?ae??ciythoueny a?ae
aeo?aeieo aeaieo (?>0,05). I?e caoyaeiiio aacia?a- ?aiiio ia?aa?ao
naeueiiiaeueico ai?iaeiaae aeaioeaeiaaiai ia??iaeo niin-oa?aaeaiue, ia
a?aeiia?aeieo aoaiao i?iaaaeaieo aeine?aeaeaiue (5-7 ? 10-
14 aei? e?eoaaiiy) ia eiinoaoiaaii noaoenoe/ii a??ia?aeii? ??cieoe?
ii-eaciee?a /anoioe aeyaeaiiy oa ai?noo ??ciiaeae?a ?ioiiaeiaoe?i?a
eeano A a eii?io?eueo?aoao. Ee?i?/ii oae?e aeeiai?oe? iieaciee?a
ei- eaeueiiai aoii?aeueiiai ?ioi?oaoo a?aeiia?aea? oi?i?aei?noue i?iya?a
aeen-iaine/iiai neiae?iio, ui iai?oanoo?oueny ia oii? iii??ii ae?aaeaieo
no?eeeo neiioii?a caaaeueii? ?ioieneeaoe??.

A aeeiai?oe? oai?iae i?e aino?iio oeeee?/iiio ia?aa?ao oyaeei? oi?ie
naeueiiiaeueico, ia oii? /ano?oiai aeyaeaiiy a eii?io?eueo?a- oao
?ioiiaeiaoe?i?a eeano A, iinooiiai i?aeaeuothoueny na?aaei? iieac-
ieee ai?noo IgA oa S?gA. Ia 10-14 aeaiue e?eoaaiiy oe? iieacieee
noa-oenoe/ii a??ia?aeii aeu? a?ae aeo?aeieo (?<0,05). I?e caoyaeiiio ia?a- a?ao oyaeei? oi?ie naeueiiiaeueico ai?iaeiaae aeaioeaeiaaiai ia??iaeo niinoa?aaeaiue, ia a?aeiia?aeieo iine?aeiaieo aoaiao i?iaaaeaieo aeine?- aeaeaiue (5-7 ? 10-14 aei? e?eoaaiiy), ia eiinoaoiaaii noaoenoe/ii a??ia?aeii? ??cieoe? iieaciee?a /anoioe aeyaeaiiy ? ai?noo a eii?i- o?eueo?aoao IgA oa S?gA. Aeuaiaaaaeai? aeai? na?ae/aoue i?i aeaoa?i?iiaai?noue nooiaiy oyae- eino? oa aa??aio?a ia?aa?ao naeueiiiaeueico ooieoe?iiaeueiei noaiii nenoaie eieaeueiiai ?ioiieia?/iiai caoenoo, ui ?aae?ciao?oueny /a?ac ?ioiiaeiaoe?ie eeano A, ianaiia?aae SIgA. Ioaea, ai?no SIgA a eii-?io?eueo?aoao – iaeei c ia'?eoeaieo ia?aee?i?/ieo oano?a ?iaeeeaoe?? nooiaiy oyaeeino? ee?i?/ieo i?iya?a naeueiiiaeueico oa i?iaiicoaaiiy ia?aa?ao oai?iae. Ine?eueee aeae?eaiiy c? na/? caoaeiee?a iiiinaeueiiiaeueico oa naeue-iiiaeueicii-eeaan??eueicii? AE? iiaeia o?aeooaaoe ye i?iya ?o iica-eeoeiai? o?aineieaoe?? aiane?aeie ?iceaae?a oeeoii?ioaeoe?? neeciai? iaieiiee eeoie, ni?anoaaeaii /anoioo aeyaeaiiy, aeo?aei? aeai? oa aeeiai?eo na?aaei?o iieaciee?a ai?noo IgA oa SIgA a eii?io?eueo?aoao a 2-o a?oiao oai?eo, aeae?eaieo c a?aooaaiiyi ?acoeueoao?a iie?noa- no?aoieo aaeoa??ieia?/ieo aeine?aeaeaiue. O 79 oai?eo ia iiiinaeueiiia- eueic oa anioe?eiaaio c eeaan??eueicii oi?io oai?iae (iniiaia a?oia), e??i aeii?iaeiaiue, iaeei aai iaeaeaa caoaeieee ia ??cieo aoaiao oai?i- ae aeae?eaii oaeiae c? na/?. O 67 aiaeia?/ieo oai?eo (eiio?ieueia a?oia) ai?iaeiaae anueiai ia??iaeo niinoa?aaeaiue caoaeieee oai?iae, ye naeueii- iaea, oae ? eeaan??ea, aeae?eyeeny eeoa c aeii?iaeiaiue. C'yniaaii, ui o oai?eo iniiaii? a?oie a eii?io?eueo?aoao ia iine?aeiaieo aoaiao oai?iae /ano?oa a?aenooi? ?ioiiaeiaoe?ie A, a ca iayaiino? oeeo ?ioii-aeiaoe?i?a a eii?io?eueo?aoao na?aaei? iieacieee ?o ai?noo ieae/?, i?ae o oai?eo eiio?ieueii? a?oie. Iicaeeoeiaa o?aineieaoe?y ao?ieia?/ieo /eiiee?a naeueiiiaeueicii? oa naeueiiiaeueicii-eeaan??eueii? AE? (iice- oeaia o?eiieoeueoo?a o oai?eo iniiaii? a?oie) ca a?aenooiino? aai i?e iecueeiio ai?no? a eii?io?eueo?aoao ?ioiiaeiaoe?i?a A, na?ae/eoue i?i i?e/aoi?noue inoaii?o aei caaacia/aiiy oeeoii?ioaeoe?? neeciai? iaieii- ee eeoie. Ioaea, iiceoeaio o?eiieoeueoo?o i?e naeueiiiaeueic? iiaeia o?aeooaaoe ye nai???aeiee ia?aee?i?/iee oano ?iaeeeaoe?? ?iceaae?a i?noeaaiai ?ioi?oaoo. I?e aea/aii? noaio OAI c'yniaaii, ui a iaaeao a?oi oai?eo ia na?aaeiueioyaeeo oa oyaeeo oi?ie naeueiiiaeueico, caeaaeii a?ae aa??aioa iiaeaeueoiai ia?aa?ao oai?iae, oaea i?e iinooieaii? ia noaoe?iia?ia e?eoaaiiy aeyaey?oueny a??ia?aeia ??cieoey iieaciee?a, ui oa?aeoa?e- cothoue OAI. Na?aae ia?aee?i?/ieo oano?a ?iaeeeaoe?? ?iceaae?a OAI, ui na?ae/aoue i?i ?icaeoie oyaeei? oi?ie oai?iae oa i?iaiicothoue caoyae- iee ia?aa?a, aeii?iothoue: iaeo?iiai?y, iecuee? iieacieee O*, cia/ia oa noaa?eueia cieaeaiiy ai?noo EA a iaeo?io?eao. I?e aiae?c? ie?aieo aeiaaee?a caoai?thaaiiy ia naeueiiiaeueic, ia'?aeiaieo ca ni?eueiith iciaeith aea??eiaeo iieaciee?a, ui oa?aeoa-?ecothoue noai OAI, c'yniaaii oaea. Ii/aoeiaee iaeo?io?eueiee eae-eioeeoic, ui noi?iaiaeaeo?oueny cia/iith aeoea?caoe??th iiaeeiaeueii? oa iaoaaie?/ii? aeoeaiino? iaeo?io?e?a, niinoa??aa?oueny, aieiaiei /e- iii, i?e na?aaeiueioyaee?e oi?i? naeueiiiaeueico c ianooiiei aino?ei oeeee?/iei ia?aa?aii oai?iae. Ioaea, oea i?iaiicii ni?eyoeeaee eiiieaen iieaciee?a OAI (a?ia??aaeoeaiee oei ooieoe?iiaeueii? ae-oeaiino? iaeo?io?e?a). Ii/aoeiaa iaeo?iiai?y, iaeii/ania iacia/ia i?aeaeuaiiy iieaciee?a iiaeeiaeueii? (ca aeaieie O*) oa iaoaaie?/ii? aeoeaiino? iaeo?io?e?a niinoa??aa?oueny, aieiaiei /eiii, i?e oyaee?e oi?i? naeueiiiaeueico, iniaeeai o aeiaaeeao ianooiiiai caoyaeiiai ia?aa?ao oai?iae, a oaeiae a aeeiai?oe? oai?iae i?e caoyaeiiio aac-ia?a?aiiio ia?aa?ao na?aaeiueioyaeei? oi?ie naeueiiiaeueico. Oea i?i-aiinoe/ii iani?eyoeeaee "oaaioeeoa?iee eiiieaen" ?iaeeeaoe?? oyaeei? oi?ie oai?iae aai oi?ioaaiiy caoyaeiiai ia?aa?ao (a?ii?aaeoeaiee oei ooieoe?iiaeueii? aeoeaiino? iaeo?io?e?a). Aeey ioe?iee aoaeoeaiino? aioa?ini?aaioa neeea?aea-I a eiiieaen-iiio e?eoaaii? oai?eo ia naeueiiiaeueic ae?oae ia?oiai ?ieo aeeooy ?acoeueoaoe a?aeiia?aeieo eiiieaenieo aeine?aeaeaiue c?noaaeai? o noi?- iiaaieo oeyoii aeiaaeeiaiai iine?aeiaiiai aeiai?o 2-o a?oi oai?eo, o yeeo i?e iinooieaii? a noaoe?iia? ia iniia? ?ic?iaeaiiai ?ioaa?aeue- iiai iieacieea aecia/aiiy nooiaiy oyaeeino? oai?iae (oaae.1) ae?aa-iinoiaaii na?aaeiueioyaeeo oi?io naeueiiiaeueico. Aei ia?oi? a?oie aa?eoei 60 oai?eo ia naeueiiiaeueic, eio?ei ia oii? iaeneiaeueii? iai?oanoaoe?? ii/aoeiaeo ee?i?/ieo i?iya?a oai?i- ae i?iieaaiiy oeoiea oa eeoie i?iaaaeaii 0,05-0,1% caaenii nee- ea?aea-I ? i?ioyaii ianooiieo 5-7 aei?a i?ecia/aii ona?aaeeio 1- 3% caaen i?aia?aoo 4-6 ?ac?a a aeaiue, o i?ii?aeeao i?ae i?eeiaiiy- ie ?ae?, o aeiaia?e aeic? 100-150 ia/ea iane o?ea. O ca'yceo c iayaieie ?iceaaeaie i?e?ioee?eoeyoe?? aioa?aeueio aeaoieneeaoe?th neeea?aeii-I ii?aeioaaee c aioo??oiueiaaiieie ?iooc?yie ?cioii?/ieo aetheici- nieueiaeo ?ic/ei?a oa neioaoe/ieo ieaciicai?iiee?a (aieiaiei /eiii, ?aiiie?aethe?i). 52 oai?eo ia naeueiiiaeueic (2-a?oia) i?aeaeaaaee aia-eia?/i?e ia?aioa?aeuei?e aeaoieneeaoe?? aac iaeii/aniiai canoinoaaiiy neeea?aea-I ona?aaeeio aai ye eiiiiiaioa ?ic/ei?a aeey i?iieaaiiy oeoiea oa eeoie. Uiaei i?eioeei?a i?ecia/aiiy oa canoinoaaiiy i?e naeueiiiaeueic? aioeaaeoa??eieo na?aaeiee?a oa ?ioeo eiiiiiaio?a eii-ieaeniiai e?eoaaiiy aeae?eai? a?oie oai?eo ia ??cieeeny. A?aenooi?noue a??ia?aeii? ??cieoe? ii/aoeiaiai oieneeico i?e iiiinaeueiiiaeueic? oa anioe?eiaaieo oi?iao oai?iae aeaee ciiao ia aeeoa?aioe?thaaoe ?o a iaaeao aeae?eaieo a?oi c?noaaeaiiy. C'yniaaii, ui i?e canoinoaaii? a eiiieaeniiio e?eoaaii? oai?eo ia naeueiiiaeueic neeea?aea-I a??ia?aeii iaioa o?eaae?noue ee?i?/ieo i?iya?a ?ioieneeaoe?eiiai oa aeeniaine/iiai neiae?ii?a. Oeueiio ni?ey?, i/aaeaeii, aeieoaaiiy aniieooaaiiy neeea?aeii-I oienei?a c i?ina?oo o?aaiiai eaiaeo oa ciaioaiiy ?o ?iaeoeoth/iai aieeao ia neioac i?i-noaaeaiaeei?a oa aeoeaaoe?th oeeee?/ieo ioeeaioeae?a ia ??ai? aioa?i- oeeo?a. Aioeae?a?aeiee aoaeo neeea?aea-I iineeth?oueny a?ae?io?eueieie aeanoeainoyie i?aia?aoo. Aeiaaaeaii oaeiae, ui i?e i?iieaaii? eeoie 0,05% caaenii neeea?aea-I o oai?eo c caoyaeieie ia?aa?aii naeueii- iaeueico ciaioothoueny i?iyae ia?aco eeoie oa iaoai?eci. C 27 oai- ?eo iiceoeaiee aoaeo iaeii?aciai? i?ioeaaeo?e eiinoaoiaaii o 12 (44,4%) oai?eo, 2-3 ?aciai? – o 10 (37,1%) oai?eo. Iioeiaeueia oaiia?aoo?a ??aeeie, ?aeoaeueiei aaaaeaiiyi eio?i? iiaeia aeinyaoe ii-neeaiiy ia?enoaeueoeee eeoie, aeecueea aei e?iiaoii?. Aeaoieneeaoe?eiee aoaeo neeea?aea-I i?aeoaa?aeaeaii ia?aee?i?/ii: oaeaeoeie oaiiaie cieaeaiiy ai?noo INI a ne?iaaooe? e?ia?. Aenieo ni?aoe?eio aeoeai?noue neeea?aea-I noiniaii INI i?aeoaa?aeaeaii oaeiae a aeno?aei?ii?aeueieo oiiaao ca aeiiiiiaith aaeue-o?iiaoia?ao??. I/a-aeaeii, iaeiei c iaoai?ci?a, ui aecia/athoue aeaoieneeaoe?eio ae?th nee- ea?aea-I, ? cieaeaiiy ai?noo INI a ne?iaaooe? e?ia? oeyoii aeieo- aaiiy ?o ?aoee?eoeyoe?? c i?ina?oo o?aaiiai eaiaeo. Ia a?aei?io a?ae ciaioaiiy ai?noo INI a ne?iaaooe? e?ia?, oaea ia 5-7 aeaiue canoinoaaiiy neeea?aea-I a eiiieaeniiio e?eoaaii? oai?eo ia naeueiiiaeueic, ui i?aeoaa?aeaeo? oaeaeeo aeaoieneeaoe?eio ae?th i?a- ia?aoo, iiceoeaiee aieea eiai ia noai OAI eiinoaoiaaii eeoa ia 10-14 aeaiue e?eoaaiiy ca aeaieie iieaciee?a O?, O*, INO-oanoo oa ai?noo EA a iaeo?io?eao. Ine?eueee na?aae iieaciee?a OAI cia/ia ? no?eea cieaeaiiy ai?noo EA a iaeo?io?eao, ca aeaieie iaoeo niinoa- ?aaeaiue, ? iaea?eueo ?ioi?iaoeaiei oanoii i?iaiicoaaiiy caoyaeiiai ia?aa?ao naeueiiiaeueico, a i?ae ai?noii INI a ne?iaaooe? e?ia? ? EA a iaeo?io?eao o oeeo oai?eo aeyaeythoueny o?ni? i?yiie?i?ei? iaaaoeai? ei?aeyoe?ei? ca'ycee (cia/aiiy eiao?oe??ioa ei?aeyoe?? r ciaoiaeeoueny a iaaeao a?ae –0,672 aei –0,794), iiceoeaiee aieea neeea?aea-I ia noai OAI iiaea aooe iiina?aaeeiaaiee iiia?aaeiueith aeaoieneeaoe?eiith ae??th i?aia?aoo. Iieaciaa a oeueiio ieai? ianoaiiy a??ia?aeiiai i?aeaeuaiiy ai?noo EA a iaeo?io?eao i?e canoinoaaii? a e?eoaaii? oai?eo ia naeueiiiaeueic neeea?aea-I eeoa ia 10-14 aeaiue e?eoaaiiy i?e cia/ii ?ai?oiio cieaeaii? ai?noo INI a ne?iaaooe? e?ia? (5-7 aeaiue e?eo- aaiiy). I/aaeaeii, iaiaaeaiiy oa i?aaethaaiiy aieeao aaeoa??eieo oienei?a oa iaoieia?/ieo iaoaaie?o?a ia nenoaio oaaioeeoico ca aeiii- iiaith canoiniaaiiai aioa?ini?aaioa iiceoeaii iicia/a?oueny ia ?? ooieoe?iioaaii?. Ine?eueee i?e naeueiiiaeueic? ia?inoaiiy ai?noo SIgA a eii-?io?eueo?aoao a aeeiai?oe? oai?iae ? i?iaiinoe/ii ni?eyoeeaith icia- eith, iiaeia aoei iiaithaaoeny, ui canoinoaaiiy aioa?ini?aaioa nee- ea?aea-I iaaaoeaii iicia/eoueny ia ia?aa?ao caoai?thaaiiy. Aaeaea, o ca'yceo c i?ioa?iiiaeoe/ieie aeanoeainoyie neeea?aea-I (I.A.Eo- oethe c? ni?aaao., 1999) ?nio? iaaaciaea ca'ycoaaiiy i?aia?aoii SIgA. Aeai? aeeiai?ee ai?noo ?ioiiaeiaoe?i?a A a eii?io?eueo?aoao o oai- ?eo ia naeueiiiaeueic c a?aooaaiiyi iaoiaeo e?eoaaiiy iiaeaii a oaae.2. Oaaeeoey 2 Aeeiai?ea ai?noo ?ioiiaeiaoe?i?a A a eii?io?eueo?aoao o oai?eo ia naeueiiiaeueic c a?aooaaiiyi iaoiaeo e?eoaaiiy Iaoiae e?eo- aaiiy (A?oia oai?eo)?ioiiaeiaoe?ie eeano A eii?io?eueo?ao?a SIgA/IgAAei ii/aoeo e?eoaaiiy (?iciae oai?iae)A iine?aeiai? aei? e?eoaaiiy5-710-14% aeya-eaiiyM±m, a/e% aeya-eaiiyM±m, a/e% aeya-eaiiyM±m, a/eC canoino- aaiiyi nee-ea?aea-I, n=6073,40,45±0,06100,0*0,69±0,02*100,0**0,89±0,07* **0,31±0,070,29±0,020,24±0,04Eiio?ieueia a?oia, n=5275,80,47±0,0979,90,58±0,0980,80,52±0,070,34±0,080,41±0,040,28±0,04?>
0,05>0,05<0,05>0,05<0,05<0,05>0,05<0,05>0,05

I?ei?oee: * – a?aei?iiino? a??ia?aei? ii??aiyii c iiia?aaei?i
aeine?aeaeaiiyi,

** – a?aei?iiino? a??ia?aei? ii??aiyii c aeo?aeieie aeaieie.

A?eueoa /anoioa aeyaeaiiy oa aeu? na?aaei? iieacieee ai?noo SIgA a
eii?io?eueo?aoao i?e canoinoaaii? a eiiieaeniiio e?eoaaii? oai-
?eo ia naeueiiiaeueic neeea?aea-I (oaae.2) na?ae/aoue i?i aeinoaoi?e
nei- oac ?o e?ioi?aeieie ee?oeiaie oiiei? eeoee oa
ooieoe?iiaeueio ni?i-iiaei?noue ai?oae?aeueieo ee?oei neeciai? iaieiiee
eeoie uiaei i?i- aeoeoe?? a?eueiiai nae?aoi?iiai eiiiiiaioa. Oaeo
eieaeueio ?ioiio a?aeiia?aeue iiaeia ioe?ieoe ye aaeaeaaoio, ui
i?aeoaa?aeaeo?oueny eiinoaoi- aaiith o oeeo oai?eo iaeii/aniith
iiceoeaiith aeeiai?eith ee?i?/ieo neiioii?a oai?iae oa ia?aee?i?/ieo
oano?a ?iaeeeaoe?? nooiaiy oieneei-iaoaaie?/ieo c?ooaiue. ? oi/
?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ia aeathoue ciiao
eaoaai?e/ii aeeeth/eoe iiaeeea?noue iaaaaeaiiai aieeao neeea?aea-I ia
ie?ai? eiiiiiaioe eieaeueiiai ?ioi?oaoo, noia?iee iiceoeaiee aoaeo
i?aia?aoo ia eieaeueiee ?ioi?oao aacia?a/iee.

Aeey c’ynoaaiiy aieeao neeea?aea-I ia /anoioo iicaeeoeiai? o?aineieaoe??
naeueiiiaee ca aeaieie iiceoeaii? o?eiieoeueoo?e ni?anoaaeaii
a?aeiia?aei? iieacieee o oai?eo a?oi ii??aiyiiy. Oae, c 60 oai?eo, a
e?eoaaii? eio?eo canoiniaaii neeea?ae-I ona?aaeeio oa ye eiiiiiaio
??aeei aeey i?iieaaiiy oeoiea ? eeoie, a aeeiai?oe? oai?iae
o?eiieoeueoo?a aoea iiceoeaiith eeoa o 23 (38,3%) oai?eo, a c 52
oai?eo eiio?ieueii? a?oie – o 33 (63,5%) oai?eo. A??ia?aeii iaioa
/anoioa iicaeeoeiai? o?aineieaoe?? naeueiiiaee ca aeaieie iiceoeaii?
o?eiieoeueoo?e i?e aeeth/aii? neeea?aea-I a eiiieaenia e?eoaaiiy
oai?eo ia naeueiiiaeueic (38,3% i?ioe 63,5%; P<0,05), aea? ciiao aaa- aeaoe i?aia?ao aoaeoeaiei na?aaeieeii iiia?aaeaeaiiy iicaeeoeiai? o?aineieaoe?? caoaeieea oai?iae. Ia oaaao caneoaiao? oaeiae aea/aiiy aieeao neeea?aea-I ia o?e-aae?noue aaeoa??iaeae?eaiiy c aeii?iaeiaiiyie (iiceoeaia eii?ieoeue- oo?a). C 60 oai?eo ia na?aaeiueioyaeeo oi?io naeueiiiaeueico, o e?eo- aaii? yeeo canoiniaoaaee neeea?ae-I, ia 14-15 aeaiue e?eoaaiiy aae-oa??iaeae?eaiiy i?eieieeinue o 50 (83,3%) oai?eo. C 52 oai?eo eiio?ieueii? a?oie a oe? oa?i?ie aaeoa??iaeae?eaiiy i?eieieeiny eeoa o 35 (67,3%) oai?eo (P<0,05). Ioaea, aeeth/aiiy neeea?aea-I a eii- ieaenia e?eoaaiiy oai?eo ia naeueiiiaeueic ni?ey? nei?i/aiith o?e- aaeino? aaeoa??iaeae?eaiiy c aeii?iaeiaiiyie. Iiceoeaiee aieea neeea?aea-I ia eieaeueiee ?ioi?oao iiaea aooe iiina?aaeeiaaiee aeaoieneeaoe?eiith ae??th i?aia?aoo. Oea i?aeoaa?aeaeo?, cie?aia, iayai?noue o?nieo i?yiie?i?eieo iaaaoeaieo ei?aeyoe?eieo ca'yce?a i?ae ai?noii INI a ne?iaaooe? e?ia? – iieacieeii nooiaiy oieneei-iaoaaie?/ieo c?ooaiue, oa ai?noii SIgA a eii?io?eueo?aoao (cia/aiiy eiao?oe??ioa ei?aeyoe?? r ciaoiaeeoueny a iaaeao a?ae –0,739 aei –0,811). I?e oeueiio i?aeaeuaiith ai?noo SIgA a eii?io?eueo?aoao ia?a- aeo? cieaeaiiy ai?noo INI a ne?iaaooe? e?ia?. Ne?ae cacia/eoe oaeiae, ui eiinoaoiaaia a iaoeo aeine?aeaeaiiyo ciaioaiiy o?eaaeino? aaeoa??iaeae?eaiiy o oai?eo ia naeueiiiaeueic i?e canoinoaaii? a eiiieaeniiio e?eoaaii? neeea?aea-I, coiiaeaia, i/aaeaeii, aeuacacia/aiith iiceoeaiith ae??th i?aia?aoo ia eieaeuei? iaoai?cie ?ioiieia?/iiai caoenoo. Aaeaea, a aeine?aeaeaiiyo in vitro aei- aaaeaii, ui neeea?ae-I ia aieiae?? aaeoa??ioeeaeiith ae??th. Ni?aiaai? ia neeea?ae?-I aaeoa??? caa??aathoue caeaoi?noue aei ?ai?iaeoeoe??. Caneoaiaothoue aiaeii/an ia oaaao iiceoeai? ?acoeueoaoe i?iaaaeaieo iaie in vitro aeine?aeaeaiue uiaei i?aeaeuaiiy /ooeeaino? naeueiiiaee oa eeaan??ee (iae/ano?oiai i?e?iaa-anioe?yioa anioe?eiaaieo oi?i oai?i- ae) aei aioea?ioee?a oa ooi?o?iieii?a i?ae aieeaii neeea?aea-I. I?aeae- uaiiy /ooeeaino? naeueiiiaee oa eeaan??ee aei aioeaaeoa??eieo na?aae- iee?a i?ae aieeaii neeea?aea-I iiaea aooe coiiaeaia oei, ui iaaeiei iiaa?oi? aaeoa??? cina?aaeaeothoueny cia/ii ae??ai?o? a?ae ia? /anoee i?a-ia?aoo (A.I.Ii?ic c? ni?aaao., 1992) ? eiioi?ioth/e ?? iiaa?oith, ii-eaaoothoue ?aae?caoe?th ?oei?aiiai aieeao aioei?e?iaiiai na?aaeieea. AENIIAEE 1. O oai?eo ia na?aaeiueioyaeeo oa oyaeeo oi?ie naeueiiiaeueico aeya- eaii ?iceaaee eieaeueiiai aiiainoaco oa oeeoii?ioaeoeaii? ni?i- iiaeiinoi neeciai? iaieiiee eeoie, coiiaeaii aeaoioeeoii ?ioii-aeiaoeiiia iinoeaai? aei? oa aeenaaeainii oaaioeeoa?ii? nenoaie caoenoo iaeo?ioieia. 2. Iaaeieia oeeoii?ioaeoeiy neeciai? iaieiiee eeoie caaacia/o?oueny, ianaiia?aae, SIgA, noieeeie aei aei? i?ioaieioe/ieo oa?iaioia. Iiaeaeuaiiy aiinoo SIgA a eii?ioieueo?aoao naiae/eoue i?i aaea- eaaoiinoue eieaeueieo iaoaiiciia iioiieiai/iiai caoenoo. Aeaoioeeo iioiiaeiaoeiiia iinoeaai? aei? aeyaey?oueny i?e oyaeeie oi?ii naeueii-iaeueico i i?iaiico? caoyaeiee ia?aaia oai?iae. 3. Iioiiaeiaoeiie iinoeaai? aei? ni?eythoue eieaeicaoei? aino?iai iioan-oeiaeueiiai caiaeueiiai i?ioeano i iiia?aaeaeothoue iicaeeoeiao o?ain-eieaoeith caoaeieeia iiiinaeueiiiaeueico oa anioeieiaaieo oi?i oai- ?iae. Ia?aaia naeueiiiaeueico aaeeeith ii?ith iaoyaeothoue aeai- oa o?eeiiiiiaioii aaeoa?ieii anioeiaoei?, neeaaeiaeie yeeo ? oiiaii-ia-oiaaiii aaeoa?i?. 4. O oai?eo ia na?aaeiueioyaeeo oa oyaeeo oi?ie naeueiiiaeueico aeya- eaii aeenaaeain ooieoeiiioaaiiy oaaioeeoa?ii? nenoaie caoenoo iaeo?ioieia, aaciina?aaeiuei i?e/aoieo aei ?aaeicaoei? eieaeueieo na-iiaaiieo iaoaiiciia iioiieiai/iiai caoenoo. Na?aae iieacieeia eii-ieaena iiaeeeaoei? oaaioeeoa?ii? iani?iiiaeiinoi iaeo?ioieia aei- iiiothoue: iaeo?iiaiiy, iecueei iieacieee oaaioeeoa?iiai /enea, cia/ia i noaaieueia cieaeaiiy aiinoo a iaeo?ioieao eaoiiiieo aieeia. Ii/aoeiaee iaeo?ioieueiee eaeeioeeoic, ui ii?aeio?oueny ci cia/iith aeoeaicaoei?th iiaeeiaeueii? oa iaoaaiei/ii? aeoeaiinoi iaeo?ioieia, aiaeaeca?eaeth? aaeaeaaoio ?aaeoeith oaaioeeoa?ii? nenoaie caoenoo iaeo?ioieia. 5. ?iaaiue INI a ne?iaaooei e?iai – iaaeieiee ia?aeeiii/iee oano iiaeeeaoei? nooiaiy oieneei-iaoaaiei/ieo c?ooaiue i e?eoa?ie aecia- /aiiy oyaeeinoi eeiii/ii? oi?ie naeueiiiaeueico, aea i?iaiinoe/ii- ai cia/aiiy uiaei oi?ioaaiiy aa?iaioa ia?aaiao oai?iae ia ia?. 6. I?e naeueiiiaeueici iiae ?iaiai INI a ne?iaaooei e?iai oa aiinoii SIgA a eii?ioieueo?aoao, a oaeiae eaoiiiieo aieeia a iaeo?ioieao, iayaii oinii i?yiieiiieii iaaaoeaii ei?aeyoeieii ca'ycee (cia/aiiy eiaoioei?ioa ei?aeyoei? r ciaoiaeeoueny a iaaeao aiae –0,811 aei –0,672), ui naiae/eoue i?i iiina?aaeeiaaiinoue ?iceaaeia eieaeueiiai aiiainoaco nooiaiai oieneei-iaoaaiei/ieo c?ooaiue. Iiaeaeuaiith aiinoo SIgA a eii?ioieueo?aoao ia?aaeo? cieaeaiiy ?iaiy INI a ne?iaaooei e?iai. 7. E?ii /ioeiai aeaoieneeaoeieiiai oa aioeaeia?aeiiai aoaeoo aioa?ini?-aaioa neeea?aea-I, canoiniaaiiai i?e i?iaaaeaiii o oai?eo ia naeue-iiiaeueic aeeoa?aioeieiaaieo aa?iaioia aioa?ini?aoei?, aeeth/ath/e aano?iaioa?ieieiiini?aoeith, aeyaeaii iiceoeaiee aieea i?aia?aoo ia eieaeueii iaoaiicie iioiieiai/iiai caoenoo, ui ?aaeiciaothoueny /a?ac SIgA oa oaaioeeoa?io nenoaio caoenoo iaeo?ioieia, caeaoiinoue eiai iiia?aaeaeoaaoe iicaeeoeiao o?aineieaoeith caoaeieeia iiii-naeueiiiaeueico oa anioeieiaaieo oi?i oai?iae, ciaiooaaoe o?e- aaeinoue aaeoa?iiaeaeieaiiy. 8. A aeineiaeaeaiiyo in vitro aeiaaaeaii caeaoiinoue neeea?aea-I iiaeaeuoaa- oe /ooeeainoue naeueiiiaee oa eeaani?ee (iae/anoioiai iie?iaa-ani- oeiyioa anioeieiaaieo oi?i oai?iae) aei aioeaiioeeia oa ooi?oiii- eiiia, aiaenooiinoue i?yii? aaeoa?iioeeaeii? ae?? i?aia?aoo noiniaii oeeo aaeoa?ie. Ciaioaiiy o?eaaeinoi aaeoa?iiaeaeieaiiy i?e canoi- noaaiii a eiiieaeniiio eieoaaiii oai?eo ia naeueiiiaeueic neeea?- aea-I iiina?aaeeiaaia iiceoeaiei aieeaii i?aia?aoo ia eieaeueiee iioiioao oa caeaoiinoth eiai iiaeaeuoaaoe /ooeeainoue caoaeieeia oai- ?iae aei aioeaaeoa?ieieo na?aaeieeia. Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe?? 1. Ia?aee?i?/i? oanoe ?iaeeeaoe?? ii?ooaiue o?c?ieia?/ieo nenoai ca- oenoo a i?iaiicoaaii? ia?aa?ao naeueiiiaeueico o ae?oae ia?oiai ?ieo aeeooy // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y ? a?io?i?y.– 1999.– ?3.– N.68-73 (o ni?aaao. c A.?.Iinothe) 2. Aeaoieneeaoe?eia, ?ioiiiiaeoethth/a oa oeeoii?ioaeoeaia aoae- oeai?noue neeea?aea-I i?e naeueiiiaeueic? o ae?oae ia?oiai ?ieo aeeooy // A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoa- oo.– 1999.– O.3, ?1.– N.243-245 (o ni?aaao. c A.?.Iinothe) 3. Ee?i?/ia, a?io?i?/ia oa ?ioiieia?/ia ioe?iea aoaeoeaiino? o?c?i- eia?/iiai iaoiaeo aoa?aioii? aeaoieneeaoe?? i?e naeueiiiaeueic? o ae?oae ia?oiai ?ieo aeeooy // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y ? a?io?i?y.– 1999.– ?1.– N.54-60 4. Ao?ieia?/i?, ai?aeai?ieia?/i? oa ee?i?/i? aniaeoe aaiethoe?? aino?eo eeoeiaeo ?ioaeoe?e // ?ioaeoe?ei? oai?iae.– 1998.– ?1.– N.33-38 5. Iie?ni?a ye na?aaeiee iiaeoeyoe?? eieaeueiiai ?ioi?oaoo i?e naeueii-iaeueic? o ae?oae ia?oiai ?ieo aeeooy // Aaaeeea? ciiiice: Iaoa??aee iaoe.-i?aeo. eiioa?aioe?? ? ieaioio Anioe?aoe?? ?ioae- oe?ii?no?a Oe?a?ie (Eooeuee, 13-14 o?aaiy 1999 ?.).– Oa?iii?eue: Oe?iaaeeieaa, 1999.– N.96-98 6. Aoaeoeai?noue aano?i- oa eieiiini?aoe?? i?e aino?eo eeoeiaeo ?ioaeoe?yo o ae?oae // Aeooaeuei? i?iaeaie ee?i?/ii? ?ioaeoieia??: Oac. aeii. 5-ai c'?caeo ?ioaeoe?ii?no?a Oe?a?ie (Oa?iii?eue, 7-9 aeiaoiy 1998 ?.).– Oa?iii?eue: Oe?iaaeeieaa, 1998.– N.175-177 7. Ee?i?ei-ai?aeai?ieia?/ia oa?aeoa?enoeea aino?eo eeoeiaeo ?ioae- oe?e eeaan??eueicii? ao?ieia?? // Oai aea.– N.162-164 (o ni?aaao. c A.?.Iinothe) 8. Iie?ni?a ye can?a aeno?aii? aeiiiiiae i?e aino?eo eeoeiaeo ?ioaeoe?yo o ae?oae // Aenia?eiaioaeueia oa ee?i?/ia o?c?ieia?y: ca. iaoe. i?aoeue aei 100-??//y eaoaae?e o?c?ieia??, 10-14 aeiaoiy 1995 ?.– Euea?a, 1995.– N.268-269 9. Aaeue-o?iiaoia?ao?/ia aeine?aeaeaiiy aieeao iie?ni?ao ia ??aaiue ie?aiiaioeae?a na?aaeiuei? iieaeoey?ii? iane a aeno?aei?ii?aeueieo oiiaao // Oai aea.– N.270 (o ni?aaao. c TH.?.A?eiao, A.I.A?e- iao) 10. Iie?ni?a a eiiieaeni?e oa?ai?? ?ioaeoe?eieo caoai?thaaiue o ae?oae // I?iaeaie ae?aaiinoeee, e?eoaaiiy oa i?io?eaeoeee ?ioaeoe?e- ieo oai?ia: Oac. aeii. 4-ai c'?caeo ?ioaeoe?ii?no?a Oe?a?ie (A?iieoey, 23-25 aa?aniy 1993 ?.).– Ee?a, 1993.– N.11 (o ni?aaao. c ?.?.Ae/e?anueeith, I.Ae.?iiaieoei) 11. Iie?ni?a a ei?aeoe?? iaoaaie?/ieo ?iceaae?a, ui noi?iaiaeaeothoueny eaoiaoeeaeicii // Oai aea.– N.69 (o ni?aaao. c ?.A.I?ieii?aei) 12. O?c?ieia?/iee iaoiae aoa?aioii? aeaoieneeaoe?? n?ea?aeii i?e ?ioaeoe?eieo oai?iaao o ae?oae // Iaoeiai-iaoiaee/i? aniaeoe o?c?ieia??: ca. iaoe. i?aoeue / Euea?anueeee iaae. ?i-o.– Euea?a, 1993.– *.??.– N.171 (o ni?aaao. c A.?.Iinothe, ?.?.Ae/e?anueeith, TH.?.A?eiao, I.A.Aeaoi, I.Ae.?iiaieoei) 13. I?eiaiaiea iieeni?aa i?e ino?uo eeoa/iuo eioaeoeeyo o aeaoae // E?aiiacaiu a iaaeeoeeia e aeieiaee: na. iao/. o?. / Iiae ?aae. aeaae. AI Oe?aeiu A.A.*oeei.– Eeaa; Noaa?iiieue, 1993.– N.168-169 (a niaao. n A.E.Aiaiiacii, E.E.Aanaoei, I.E.Aeaie- eeoei, I.A.Iano?ee) 14. I?ioeeaeoe/aneay yooaeoeaiinoue iieeni?aa a i/aaa naeueiiiae- eaciie eioaeoeee o aeaoae ?aiiaai aic?anoa // Oai aea.– N.170– 171 (a niaao. n A.E.Iinothe, TH.E.A?eiao, A.E.Aoaa?ue) 15. Aoa?aioia aeaoieneeaoe?y iie?ni?aii i?e aino?eo eeoeiaeo, ?ani??aoi?ieo a??onieo oa iae?i?ioaeoe?yo o ae?oae // IV eiia?an NOOEO: oac. aeii.– Oa?e?a, 9-14 na?iiy, 1992 ?.– N.223 (o ni?aaao. c A.?.Iinothe, I.A.Aeaoi) 16. Yooa?aioiay aeaoieneeaoeey iieeni?aii a eiiieaeniie oa?aiee eioaeoeeiiiuo caaieaaaiee o aeaoae // Iaaeaeoia?iaeiay eiioa- ?aioeey ii i?iaeaiai iaaeeoeeiu eaoano?io: oac. aeiee.– Eeaa, 1992.– N.92-93 (a niaao. n A.E.Iinothe, I.E.Aeaieeeoei, A.E.Aiaiiacii, TH.E.A?eiao, A.E.Aoaa?ue) 17. Iie?ni?a a i?io?eaeoeoe? eeoeiaeo ?ioaeoe?e oa i?aaethaaii? i?iya?a oiene/ii? aioa?iiao?? i?e ?ani??aoi?ieo a??onieo ?ioaeoe?yo o ae?oae // 12-e Oe?a?inueeee ?anioae?eainueeee c'?cae i?e?ia?ieia?a, ai?aeai?ieia?a ? ia?aceoieia?a: oac. aeii.– Ee?a, 1991.– *.??.– N.30 (o ni?aaao. c A.?.Iinothe, TH.?.A?eiao, I.?.N?/ei??cii, I.Ae.?iiaieoei, C.I.Iaeiia/iith) 18. Yioa?ini?aaiou a ea/aiee e i?ioeeaeoeea eioaeoeeiiiuo caai-eaaaiee o aeaoae // Iaoiaee/aneea ?aeiiaiaeaoeee, iaeia?aiu ?an-ioaeeeaineei oeaio?ii iao/iie iaaeeoeeineie eioi?iaoeee IC ONN?.– Eueaia, 1991.– 28 n. (a niaao. n A.E.Iinothe, I.A.Ne/ei- ?ecii, E.A.Aaeaeoeii, I.E.Aeaieeeoei, TH.E.A?eiao, I.A.Iia-eyiueneie, A.E.Aoaa?ue, I.Ae.?iiaieoei, I.A.Aeaoi) 19. Yioa?ini?aaiou a ea/aiee ino?uo eeoa/iuo eioaeoeee o aeaoae // Ieaioi i?aaeaiey ?anioaeeeaineiai iao/ii-iaaeeoeeineiai ia- uanoaa eioaeoeeiienoia: oac. aeiee.– Eeaa, 1990.– N.97 (a niaao. n A.E.Iinothe, E.A.Aaeaeoe, I.A.Ne/ei?ecii, I.A.Iano?ee, I.Ae.?iiaieoei) Aiioaoe?y. I?ieii?a I.A. Ee?i?/ia ? i?iaiinoe/ia cia/aiiy ?iceaae?a ei-eaeueiiai ?ioi?oaoo i?e naeueiiiaeueic? o ae?oae ?aiiueiai a?eo oa iiaeeeaino? ?o ei?aeoe??.– ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae.– Ee?anueeee ia-oeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai IIC Oe?a?ie, Ee?a, 1999. Ia iniia? ee?i?/iiai oa eaai?aoi?iiai ianoaaeaiiy 146 oai?eo ia naeueiiiaeueic ae?oae ?aiiueiai a?eo aia?oa aeiaaaeaii aeaoa?i?iiaai?noue nooiaiy oyaeeino? oa aa??aioa ia?aa?ao oai?iae oeeoii?ioaeoeaiith ni?iiiaei?noth neeciai? iaieiiee eeoie, ui caaacia/o?oueny ?ioiiaeiaoe?iaie i?noeaai? ae?? oa oaaioeeoa?iith nenoaiith caoenoo iaeo?io?e?a. Aecia/aii /eiieee, ui coiiaeththoue ianieyoeeaee ia?aa?a naeueiiiaeueico. Cia/ii iaoyaeothoue ia?aa?a naeueiiiaeueico aeai- oa o?eeiiiiiaioi? aaeoa??ei? anioe?aoe??, neeaaeiaeie yeeo ? oiiaii-iaoiaaii? aaeoa???. C'yniaaii, ui ?ioiiaeiaoe?ie i?noeaai? ae?? ni?eythoue eieae?caoe?? aino?iai ?ioanoeiaeueiiai caiaeueiiai i?ioeano ? iiia?aaeaeothoue iicaeeoeiao o?aineieaoe?th caoaeiee?a iiiinaeueiiiaeueico oa anioe?eiaaieo oi?i oai?iae. Aeao?oeeo SIgA coiiaeth? caoyaeiee ia?aa?a naeueiiiaeueico. Aeenaaeain ooieoe?iioaaiiy oaaioeeoa?ii? nenoaie iaeo?io?e?a a?aeaeca?eaeth? oyaee?noue ee?i?/ieo oi?i naeueiiiaeueico oa i?iaiico? caoyaeiee ia?aa?a oai?iae. Na?aae iieaciee?a eiiieaena ?iaeeeaoe?? ?iceaae?a OAI aeii?iothoue: iaeo?iiai?y, iecuee? iieacieee O*, cia/ia ? noaa?eueia cieaeaiiy ai?noo a iaeo?io?eao EA. Aia?oa ?ic?iaeaii ? aea/aii aoaeoeai?noue iaoiaeo aano?iaioa?ieieiiini?aoe?? neeea?aeii-I i?e naeueiiiaeueic? o ae?oae ?aiiueiai a?eo. C'yniaaii, ui neeea?ae-I, ie??i aeaoieneeaoe?eiiai oa aioeae?a?aeiiai aoaeoo, iiceoeaii aieeaa? ia eieaeuei? iaoai?cie ?ioiieia?/iiai caoenoo, ui ?aae?ciaothoueny /a?ac SIgA oa OAI, iiia?aaeaeo? iicaeeoeiao o?aineieaoe?th caoaeiee?a iiiinaeueiiiaeueico oa anioe?eiaaieo oi?i oai?iae, ciaioo? o?eaae?noue aaeoa??iaeae?eaiiy. A aeine?aeaeaiiyo in vitro aeiaaaeaii caeaoi?noue neeea?aea-I i?aeaeuoaaoe /ooeea?noue naeueiiiaee oa eeaan??ee (iae/ano?oiai i?e?iaa-anioe?yioa anioe?eiaaieo oi?i oai?iae) aei aioea?ioee?a oa ooi?o?iieii?a. Eeth/ia? neiaa: naeueiiiaeueic, ae?oe ?aiiueiai a?eo, ee?i?ea, aiaeioieneeic, eieaeueiee ?ioi?oao, aioa?ini?aoe?y. Aiiioaoeey I?ieiiea A.A. Eeeie/aneia e i?iaiinoe/aneia cia/aiea ?anno?ienoa eieaeueiiai eiioieoaoa i?e naeueiiiaeeaca o aeaoae ?aiiaai aic?anoa e aiciiaeiinoe eo ei??aeoeee.– ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.13 – Eioaeoeeiiiua aieacie.– Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei.E.A.A?iiaoaaneiai IC Oe?aeiu, Eeaa, 1999. Ia iniiaaiee eeeie/aneiai e eaai?aoi?iiai ianeaaeiaaiey 146 aeaoae ?aiiaai aic?anoa, aieueiuo naeueiiiaeeacii, aia?aua onoaiiaeaia aeaoa?ieie?iaaiiinoue noaiaie oyaeanoe e aa?eaioa oa/aiey aieacie ninoiyieai oeeoii?ioaeoeee neecenoie iaieiiee eeoae, iaania/eaathuaeny eiioiiaeiaoeeiaie ianoiiai aeaenoaey e oaaioeeoa?iie nenoaiie caueou iaeo?ioeeia. Eco/aiu eeeieei-yieaeaieieiae/aneea iniaaiiinoe iiiinaeueii-iaeeaca e annioeee?iaaiiuo oi?i aieacie. Onoaiiaeaii, /oi ia noaiaiue oyaeanoe eeeie/aneie oi?iu naeueiiiaeeaca e /anoioo oi?ie?iaaiey caoyaeiiai oa/aiey aieacie iaaeaaii?eyoiia aeeyiea ieacuaatho aeaoo- e o?aoeiiiiiaioiua annioeeaoeee aicaoaeeoaey n oneiaii-iaoiaaiiuie aaeoa?eyie. Eiioiiaeiaoeeiu ianoiiai aeaenoaey, i?aaeaea anaai, SIgA, niinianoaotho eieaeecaoeee ino?iai ainiaeeoaeueiiai eioanoeiaeueiiai i?ioeanna e i?aaeoi?aaeaeatho aiaeeoa/ioth o?aineieaoeeth aicaoaeeoaeae iiiinaeueiiiaeeaca e annioeee?iaaiiuo oi?i aieacie. Iiauoaiea niaea?aeaiey SIgA a eii?ioeeueo?aoao o aieueiuo naeueiiiaeeacii a aeeiaieea aieacie naeaeaoaeuenoaoao ia aaeaeaaoiinoe eieaeueiuo iaoaieciia eiioiieiae/aneie caueou. Aeaoeoeeo SIgA iaaethaeaaony i?e oyaeaeuo oi?iao naeueiiiaeaca e i?iaiice?oao caoyaeiia oa/aiea aieacie. O aieueiuo naeueiiiaeeacii auyaeyaony aeenaaeain ooieoeeiie?iaaiey oaaioeeoa?iie nenoaiu caueou iaeo?ioeeia, iaiin?aaenoaaiii i?e/anoiuo e ?aaeecaoeee eieaeueiuo naiiaaiiuo iaoaieciia eiioiieiae/aneie caueou. N?aaee iieacaoaeae eiiieaena eiaeeeaoeee oaaioeeoa?iie ianinoiyoaeueiinoe iaeo?ioeeia aeiieie?otho: iaeo?iiaiey, ieceea iieacaoaee O*, cia/eoaeueiia e noaaeeueiia nieaeaiea niaea?aeaiey EA a iaeo?ioeeao. Aia?aua ?ac?aaioai iaoiae aano?iyioa?ieieiiini?aoeee neeea?aeii-I e eco/aia yooaeoeaiinoue aeeooa?aioee?iaaiiuo aa?eaioia aai i?e naeueiiiaeeaca o aeaoae ?aiiaai aic?anoa. Onoaiiaeaii, /oi neeea?ae-I, e?iia /aoeiai aeaoieneeaoeeiiiiai e aioeaeea?aeiiai yooaeoa, iieiaeeoaeueii aeeyao ia eieaeueiue eiioieoao e OAI, i?aaeai?aaeaeaao aiaeeoa/ioth o?aineieaoeeth aicaoaeeoaeae iiiinaeueiiiaeeaca e annioeee?iaaiiuo oi?i aieacie, oiaiueoaao i?iaeieaeeoaeueiinoue aaeoa?eiauaeaeaiey. A enneaaeiaaieyo in vitro onoaiiaeaia niiniaiinoue neeea?aea-I iiauoaoue /oanoaeoaeueiinoue naeueiiiaeeu e eeaaneaeeu (iaeaieaa /anoi ano?a/athuaainy iee?iaa-annioeeaioa annioeee?iaaiiuo oi?i aieacie) e aioeaeeoeeai e ooi?oeiieiiai, ionoonoaea aaeoa?eioeeaeiiai aeeyiey i?aia?aoa ia yoe aaeoa?ee. Oiaiueoaiea aeeeoaeueiinoe aaeoa?eiauaeaeaiey i?e aeeth/aiee a eiiieaeniia ea/aiea naeueiiiaeeaca yioa?ini?aaioa neeea?aea-I naycaii n iieiaeeoaeueiui aeeyieai i?aia?aoa ia eieaeueiue eiioieoao e niiniaiinoueth aai iiauoaoue /oanoaeoaeueiinoue aicaoaeeoaeae iiiinaeueiiiaeeaca e annioeee?iaaiiuo oi?i aieacie e aioeaaeoa?eaeueiui n?aaenoaai. Iainiiaaiu e i?aaeeiaeaiu aeeooa?aioee?iaaiiua aa?eaiou aano?iyioa?ieieiiini?aoeee neeea?aeii-I i?e ?acee/iuo aa?eaioao eeeie/aneiai oa/aiey naeueiiiaeeaca. Eeth/aaua neiaa: naeueiiiaeeac, aeaoe ?aiiaai aic?anoa, eeeieea, yiaeioieneeic, eieaeueiue eiioieoao, yioa?ini?aoeey. Annotation Prokopiv O.V. Clinical and prognostic significance of local immune disturbances in salmonellosis in early childhood and the possibility of their correction.– Manuscript. Dissertation for obtaining scientific gegree of candidate of Science (Medicine), speciality 14.01.13 – Infections diseases.– Kyjv Research Institute of Epidemiology and Infections Diseases named after L.V.Gromashevsky of MPH of Ukraine, Kyjv, 1999. On the basis of clinical and laboratory studies of 146 children of early age having salmonellosis, determining the severity level and the variant of the course of the disease by cytoprotective ability of the mucous membrane of the intestines, it being provided with local action immunoglobulins and phagocytic system of neutrophils defence, has been proved for the first time. Causes stipulating an unfavourablecourse of salmonellosis have been determined.The course of salmonellosis is significantly complicated by two- and three component bacterial associations, conventionally pathogenic bacteria being their constituent. It has been stated that immunoglobulins of the local action contribute to the localization of acute intestinal inflammatory process and prevend extraintestinal translocation of the causative agents of monosalmonellosis and associeted forms of the disease. Deficiency of SIgA results in protracting the course of salmonellosis. Dysbalance of the functioning of phagocytic system of neutrophils reflects the severity of clinical forms of salmonellosis and prognosticates protracted course of the disease. Among indices of indication complex of disturbances of phagocytic activity of neutrophils predominate the following: neutropenia, low indices of phagocytes number, significant and stable lowering of the content of cation proteins in neutrophils. The method of gastroenterocolonosorption with sillard-P in salmonellosis in early childhood has been worked out for the first time and its efficiency has been studied. It has been stated that enterosorbent sillard-P, besides its detoxicational and a tidiarrheal effect, influences positively local mechanisms of immunological defense realised through SIgA and phagocytic activity of neutrophils, prevents extraintestinal translocation of the causetive agents of monosalmonellosis and associated forms of the disease, diminishes the duration of bacteria release. In studies in vitro the ability of sillard-P to increase sensitivity of Salmonella and Klebsiella (the most widespread microbe-associate of associated forms of the disease) to antibiotics and fluoroguinoline has been proved. Key words: sallmonellosis, children of early age, clinic, endotoxicosis, local immunity, enterosorption. IA?AE?E OIIAIEO IICIA*AIUe ANE–a?eueiee nae?aoi?iee eiiiiiaioAE?–aino?? eeoeia? ?ioaeoe??A?A?–aino?? ?ani??aoi?i? a??oni? ?ioaeoe??IgA–?ioiiaeiaoe?ie AIgM–?ioiiaeiaoe?ie IIgG–?ioiiaeiaoe?ie GEA–eao?iii? a?eeeINI–iieaeoee na?aaeiuei? ianeINO-oano–oano a?aeiiaeaiiy i?o?ineiueiai oao?acie?thIssE–iie?ii?oiiyaea?i? eaeeioeeoeSIgA–nae?aoi?i? ?ioiiaeiaoe?ie AOIA–oiiaii iaoiaaii? aioa?iaaeoa???O?–oaaioeeoa?iee ?iaeaenO*–oaaioeeoa?ia /eneiOe?E–oee?eoethth/? ?ioii? eiiieaeneOeE–oeeoio?i?/iee eiao?oe??io

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