I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ea?ae?ieia?? ?i. aeaae.
I.Ae.No?aaeanea

I?IOeAIEI AAEEIA IEAENAIAe??AIA

OAeE: 616-002.72-085:612.017

?IOAINEAIA OA?AI?ss ?AAIAOE*IEO CAOAI?THAAIUe C AOOI?IOIIEI OA
?IOIIEIIIEAENIEI IAOAI?CIII ?ICAEOEO

14.01.12 – ?aaiaoieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea IIC Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeaiei Aieiaeeie?
Ieeieaeiae/, aee?aeoi?, caa?aeoaa/ a?aeae?eaiiy ?aaiaoieia??
Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia??
?i.aeaae.I.Ae.No?aaeanea IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eenaiei A?eai??e ?aaiiae/, caa?aeoaa/
eaoaae?e n?iaeii? iaaeeoeeie c eo?nii ee?i?/ii? ?ioiieia?? oa
aea?aieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe
?i.I.E.Ooieea IIC Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani? Ieeoea Oa?an Aeaieniae/, caa?aeoaa/
eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia ?2 Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i.I.I.Aiaiiieueoey

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y
IIC Oe?a?ie, eaoaae?a aini?oaeueii? oa?ai?? ?2

Caoeno a?aeaoaeaoueny 16 ethoiai 1999 ?ieo i ____ aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea

ca aae?anith: 252151, i.Ee?a – 151, aoe.Ia?iaeiiai Iiie/aiiy, 5.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ea?ae?ieia?? ?i.aeaae. I.Ae.No?aaeanea

ca aae?anith: i.Ee?a, aoe.Ia?iaeiiai Iiie/aiiy, 5

Aaoi?aoa?ao ?ic?neaiee 16 n?/iy 1999 ?ieo

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Aeaye N.?

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. A inoaii? aeanyoee?ooy e?ea??-?aaiaoieiae
niinoa??aathoue cia/ia i?aeaeuaiiy ??aiy ?aaiaoe/ieo caoai?thaaiue c
aooi?ioiiei oa ?ioiieiiieaeniei iaoai?ciii ?icaeoeo. A Oe?a?i? oe?
caoai?thaaiiy ? iaeiioe?ai?oei eeanii na?aae oai?ia aioo??oi?o i?aai?a,
ui ni?e/eiththoue aenieo ?iaae?aeecaoe?th ianaeaiiy i?aoeacaeaoiiai a?eo
(Eiaaeaiei A.I., 1997). Caeaa?eueoiai – oea oai?? ia nenoaiiee /a?aiiee
aia/ae (N*A), ?aaiaoi?aeiee a?o?eo (?A), nenoaii? aaneoe?oe (NA),
neea?iaea?i?th. Oe? caoai?thaaiiy oa?aeoa?ecothoueny nenoaiiei oeiii
caiaeaiiy a ??cieo i?aaiao oa nenoaiao, ye? ii?aeiai? i?ae niaith
?icaeoeii aooi?ioiiiai oa ?ioiieiiieaeniiai i?ioeano , a oaeiae
iaaei??iei o?a?iciooai?aiiyi (Ianiiiaa A.I., 1997). Uiaei ia’?aeiaiiy
oeeo oai?ia o a?oio nenoaiieo caoai?thaaiue niieo/ii? oeaieie (NCNO), oi
?nio? ni?euei?noue ie?aieo ee?i?/ieo i?iya?a, iniaeeai ia ?aii?o
noaae?yo ?icaeoeo aooi?ioiiiai i?ioeano; caaaeuei? oa oa?aeoa?i? aeey
eiaeiiai caoai?thaaiiy ?ioiieia?/i? ia?ea?e, aeecuee? i?eioeeie
i?ioecaiaeueii? oa ?ioiinoi?aneaii? oa?ai?? (Aaiaea ?.I., Eiaaeaiei
A.I., Eenaiei A.?., Na?ioeeoeueeee A.N., 1996).

Ia no/aniiio aoai? a ?aaiaoieia?? ?niothoue ??ci? iaoiaee e?eoaaiiy NCNO
?c canoinoaaiiyi ianoa?i?aeieo i?ioecaiaeueieo i?aia?ao?a (IICI),
ei?oeeinoa?i?ae?a, o?iie?iiaeo i?aia?ao?a oa oeeoinoaoee?a (Ianiiiaa
A.A., 1997). O?eaaeee, /anoi i?ia?anoth/ee ia?aa?a NCNO, iaaeinoaoiy
aoaeoeai?noue /e oneeaaeiaiiy oa?iaeioa?ai??, iniaeeai o ?ac?
ia?i?aeueiiai i?eeiio e?ea?nueeeo i?aia?ao?a, iio?aaothoue ?ic?iaeaiiy
iiaeo iaoiae?a ? i?aeoiae?a o ?o e?eoaaii?. Ee?i?/iee ia?aa?a NCNO
iiaea oneeaaeieoeny ?icaeoeii aooi?ioiieo e?ec?a ? naioe/ieo noai?a
(Eenaiei A.?., 1997). O ?ac? aooi?ioiieo e?ec?a iniiaiei iaoiaeii
e?eoaaiiy ? ?ioiinoi?aneaia oa?ai?y aetheiei?oeeinoa?i?aeaie (AEN) ?
oeeoinoaoeeaie (Aiiniaa E.I., 1997; Eenaiei A.?., 1997; Nieiaeia N.E.,
1989). Cia/io ?ieue a?ae?a?athoue ? aeno?aei?ii?aeuei? iaoiaee
aeaoieneeaoe?? — aaiini?aoe?y, ieaciaoa?ac, e?ioioeeoiieaciaoa?ac
(Ai?iaeaoeueeee A.I., 1986; Eenaiei A.?., 1996; ss?aiaiei I.A., 1997).
Oa aei oeueiai /ano iiai?noth ia ae??oaia ieoaiiy i?i aca?iica’ycie i?ae
ieaciaoa?acii (IO) oa ioeuen-oa?ai??th (IO) i?e e?eoaaii? ?aaiaoe/ieo
oai?eo. Ia aecia/ai? e?eoa??? aoaeoeaiino? oa a?aeai?o oai?eo aeey
i?iaaaeaiiy ?ioaineaiiai e?eoaaiiy iaoiaeii IO oa IO AEN a eiia?iaoe??
c IO c o?aooaaiiyi ee?i?ei-?ioiieia?/iiai noaio.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Ia?aiee iai?yiie
aeine?aeaeaiue ni?aiaaea? c aeine?aeaeaiiyie, ye? i?iaiaeyoueny o
a?aeae?eaii? ?aaiaoieia?? Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae. No?aaeanea. Io?eiai? ?acoeueoaoe ?
neeaaeiaith caeeth/iiai ca?oo a?aeae?eaiiy i?i iaoeiai-aeine?aeio ?iaioo
1994–1997??. ca oaiith “?ic?iaeoe iiao iaaee/io oaoiieia?th ?ioaineaiiai
e?eoaaiiy oa caaacia/eoe ?ai?n?th ?aaiaoe/ieo caoai?thaaiue c
aooi?ioiiei oa ?ioiieiiieaeniei iaoai?ciii ?icaeoeo” (? aea?ae.
?a?no?aoe?? 0195OO).

Iaoa ? caaaeaiiy aeine?aeaeaiiy. ?ic?iaeoe e?eoa??? ioe?iee
aoaeoeaiino? ?ioaineaiiai e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue c
aooi?ioiiei oa ?ioiieiiieaeniei iaoai?ciii ?icaeoeo iaoiaeii IO oa IO a
eiia?iaoe?? c IO, aecia/eoe i?eioeeie a?aeai?o oai?eo, yeei iiaeia
canoiniaoaaoe oe? iaoiaee e?eoaaiiy.

I?ae /an aeeiiaiiy ?iaioe ae??ooaaeeny ianooii? caaaeaiiy:

1. Aea/eoe ?ioi?iaoeai?noue ?ioiieia?/ieo oa ee?i?ei-a?io?i?/ieo
iieaciee?a o oai?eo ia NCNO aeey iii?oi?eiao ?o ee?i?/iiai ia?aa?ao oa
?ai?n??.

2. Aea/eoe ae?th IO ia ee?i?ei-eaai?aoi?i? oa a?io?i?/i? iieacieee e?ia?
o oai?eo ia N*A, ?aaiaoi?aeiee a?o?eo (?A), aaii?aa?/iee aaneoe?o (AA).

3. Aea/eoe noai ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo o oeeo oai?eo
aiane?aeie e?eoaaiiy IO.

4. Iaa?oiooaaoe e?eoa??? a?aeai?o oai?eo ia NCNO aeey i?iaaaeaiiy IO oa
IO c IO.

5. I?iaanoe ?ioaineaia e?eoaaiiy aooi?ioiieo e?ec?a iaoiaeii IO o
ii?aeiaii? c IO ? aeaoe ee?i?ei-?ioiieia?/io ioe?ieo aoaeoeaiino?
oeueiai iaoiaeo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aecia/aii e?eoa???
a?aeai?o oai?eo aeey ?ioaineaii? oa?ai?? caeaaeii a?ae aeo?aeiiai
?ioiiiai noaoono. Aeyaeaii iniaeeaino? noaio ?ioiii? nenoaie i?e
na?aaeiueiio oa aenieiio nooiaiyo aeoeaiino? aooi?ioiiiai i?ioeano.
?ic?iaeaii ia’?eoeai? e?eoa??? ioe?iee IO oa IO c IO c o?aooaaiiyi
?ioiia?aie oa ee?i?ei-a?io?i?/ieo iieaciee?a e?ia?.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeiaaaeaia iaiao?aei?noue
aeei?enoaiiy iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo aeey
ioe?iee aoaeoeaiino? IO oa IO c IO, a oaeiae aecia/aii e?eoa??? a?aeai?o
oai?eo aeey canoinoaaiiy oeeo iaoiae?a e?eoaaiiy. ?ic?iaeaii
ee?i?ei-?ioiieia?/i? e?eoa??? ioe?iee ?ioaineaiiai e?eoaaiiy aooi?ioiieo
e?ec?a.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. ?acoeueoaoe
aeine?aeaeaiiy ai?iaaaeaeaii a i?aeoeeo ?iaioe ianooiieo a?aeae?eaiue:
ee?i?/ii? ?aaiaoieia?? i?nueei? e?ea?i? ?5 (i. E?eaee ??a),
?anioae?eainueeiai ?aaiaoieia?/iiai oeaio?o, ?aaiaoieia?/iiai
a?aeae?eaiiy ee?i?/ii? e?ea?i? ?6 (i.Ee?a), oa?aiaaoe/iiai a?aeae?eaiiy
iaeanii? ee?i?/ii? e?ea?i? ?1 oa i?nueei? ee?i?/ii? e?ea?i? ?3
(i.*a?i?aoe?), ui i?aeoaa?aeaeo?oueny aeoaie ai?iaaaeaeaiiy.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeaii ee?i?/ia
ianoaaeaiiy oai?eo oa ?o a?aea?? aeey e?eoaaiiy IO oa IO c IO.
I?iaaaeaii e?eoaaiiy oai?eo iaoiaeii IO oa IO. Aeeiiaii caa?? iaoa??aeo
aeey ?ioiieia?/iiai aeine?aeaeaiiy. Ocaaaeueiaii oa noaoenoe/ii
ia?iaeaii ?acoeueoaoe aeine?aeaeaiiy, i?aeaioiaeaii iaoeia? aeai? aei
ioae?eaoe??.

?ioiieia?/i? aeine?aeaeaiiy i?iaaaeaii ?acii ?c ni?a?ia?oieeaie
eaai?aoi??? ee?i?/ii? ?ioiieia?? Oe?a?inueeiai IAe? ea?ae?ieia?? ?i.
aeaae. I.Ae. No?aaeanea (ea??aiee — ae-? a?ie. iaoe Aaa?eeaiei O.?.).

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny oa iaaiai?thaaeeny ia I Eiia?an? ?aaiaoieia?a Oe?a?ie
(Oa?iii?eue, 1993); ?anioae?eainueeiio neiiic?oi? ?aaiaoieia?a (Iaeana,
1995); iaoeiai-i?aeoe/i?e eiioa?aioe?? ?aaiaoieia?a Oe?a?ie (Aeiiaoeuee,
1996); VI Eiia?an? Na?oiai? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo
oiaa?enoa (Iaeana, 1996); II Iaoe?iiaeueiiio Eiia?an? ?aaiaoieia?a
Oe?a?ie (Ee?a, 1997).

?iaioo ai?iaiaaii ia ni?eueiiio can?aeaii? a?aeae?eaiue ee?i?/ii?
?aaiaoieia??, oai?ia i?iea?aea oa aaae na?oey, ee?i?/ii? a?io?i??,
ee?i?/ii? ?ioiieia?? Oe?a?inueeiai iaoeiai-aeine?aeiiai ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea oa eaoaae?e oa?ai?? ?
?aaiaoieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i.
I.E.Ooieea.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 20 iaoeiaeo ?ia?o:
4 noaoo? (2 c ieo naiino?ei?) oa 16 oac?a.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 189 noi??ieao
eiii’thoa?iiai oaenoo, neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e,
/ioe?ueio aeaa iniaenoeo aeine?aeaeaiue, aeniiae?a oa nieneo
aeei?enoiaaieo e?oa?aoo?ieo aeaea?ae. Oaeno ?ethno?iaaii 23 iaethieaie
oa 38 oaaeeoeyie, ui caeiathoue 61 noi??ieo oaenoo. Nienie e?oa?aoo?e
neeaaea?oueny c 299 aeaea?ae a?o/eciyii? oa ca?oa?aeii? e?oa?aoo?e.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

Ianoaaeaii 182 oai?eo ia NCNO a?eii a?ae 18 aei 50 ?ie?a. Ae?aaiic N*A,
?A, AA oa aoceeeiaee ia??a?oa???o (AI) anoaiiaethaaany ia iniia?
ae?aaiinoe/ieo e?eoa???a A?A (1989). O 156 oai?eo anoaiiaeaii II
nooi?iue aeoeaiino? ?aaiaoe/iiai i?ioeano, o 26 – III nooi?iue
aeoeaiino?.

An? oai?? aoee ?iciiae?eai? ia aea? a?oie: iniiaio (IA) – 106 /ieia?e oa
eiio?ieueio (EA) – 75 /ieia?e.

Aei IA oa?eoee 30 oai?eo ia N*A, 35 — ia ?A, 16 — ia AA ? 26 — c
aooi?ioiieie e?ecaie, ye? aeieeee ia oii? aenieiai nooiaiy aeoeaiino?
N*A (21 oai?ee) oa AI (5 oai?eo). Oai?ei ?c IA i?iaiaeeee eo?n IO (aeey
i?io?eaeoeee “rebound”-aoaeoo i?ae /an ieaciicai?uaiiy aaiaeeee 150 ia
nieth-ei?oaoo aai ?ioiai AEN a aea?aaeaioi?e aeic?), cie?aia oai?ei c
aooi?ioiieie e?ecaie – IO iaoeei?aaei?cieiiii o ii?aeiaii? c IO. EA
neeaaeaee 75 oai?eo a?aeiia?aeiiai a?eo, noao?, o?eaaeino? o?ii?/iiai
i?ioeano, yeei i?iaiaeeee o?eueee o?aaeeoe?eio oa?iaeioa?ai?th (IICI,
AEN).

Aeey ioe?iee aoaeoeaiino? e?eoaaiiy, e??i ee?i?/ieo aeaieo, aei oaaae
a?aee ?acoeueoaoe eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy: OIA, e?euee?noue
eaeeioeeo?a e?ia?, ?aaeoe?y ia N-?aaeoeaiee a?eie (N?A), ??aaiue
o?a?eiiaaio, i?io?iia?iiaee ?iaeaen, caaaeueiee a?eie ne?iaaoee e?ia? oa
eiai o?aeoe??, n?aeiao i?iao, na?iioei?ae, aeiaoe?ie e?ia?,
?aaiaoi?aeiee oaeoi?, oano ia iayai?noue LE-ee?oei, aioeo?ea aei iAeIE
oa aeAeIE o iaoieia?/iiio oeo??. Oaeiae aecia/aee caaaeueiiee?i?/i?
iieacieee na/?: aeiaiao i?ioa?io??th, i?iao ca Ia/eii?aieii,
eiioeaio?aoe?eio caeaoi?noue ie?ie (i?iaa ca Ceiieoeueeei).

Aeey ioe?iee ee?oeiiiai ?ioi?oaoo aeei?enoai? iaoiaee aecia/aiiy
e?eueeino? Oe, Oo, On, Ae ca aeiiiiiaith iiiieeiiaeueieo aioeo?e.
Oaaioeeoa?io aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a aecia/aee a oano?
?aaeoeoe?? i?o?ineiueiai oao?acie?y (INO). Aeey oa?aeoa?enoeee ?aca?aieo
iiaeeeainoae iaeo?io?eueieo a?aioeioeeo?a o INO-oano? aecia/aee
??cieoeth i?ae iieacieeaie niiioaiiiai oa ?iaeoeiaaiiai INO-oanoo o
a?aenioeao. Aeey ioe?iee aoii?aeueii? eaiee ?ioi?oaoo aecia/aee:
?ioiiaeiaoe?ie (Ig) eean?a G, M, A ca iaoiaeii Manchini (1965); ??aaiue
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) ca Digeon (1977);
eiiieaiaioa?io aeoeai?noue ne?iaaoee e?ia? aecia/aee ca aaiinoacii
nainea?e?ciaaieo a?eo?ioeeo?a aa?aia.

O i?ioean? ianoaaeaiiy oai?eo aeei?enoiaoaaee ?ino?oiaioaeuei? iaoiaee
aeine?aeaeaiiy: aeaeo?iea?ae?ia?ao?th, oiiiea?ae?ia?ao?th,
?aioaaiineii?th i?aai?a a?oaeii? ee?oee, ?aioaaiia?ao?th noaeia?a.

O ?ac? aeyaeaiiy II nooiaiy aeoeaiino? ?aaiaoe/iiai i?ioeano i?ecia/aee
IO, III nooiaiy aeoeaiino? c aooi?ioiieie e?ecaie – IO c IO.

IO i?iaiaeeee ca iaoiaeeeith A.I.Ai?iaeaoeueeiai oa ni?aaaoi??a (1986).
Ia eo?n e?eoaaiiy i?ecia/aee i’youe i?ioeaaeo? IO /a?ac aeaiue c
aeeo/aiiyi ia iaioa i?ae 1,5 e ieacie. IO i?iaiaeeee
iaoee-i?aaei?cieiiii ii 1000 ia uiaeaiii i?ioyaii o?ueio aei?a.
Ianoaaeoaaee oai?eo aei oa i?ney eo?no e?eoaaiiy.

?acoeueoaoe aeine?aeaeaiue ia?iaeaii ca aeiiiiiaith
iaoaiaoeei-noaoenoe/ieo iaoiae?a, ??cieoey iieaciee?a aaaaeaeany
noaoenoe/ii a??ia?aeiith o ?ac? ?<0,05 ca e?eoa???i No’thaeaioa. ?acoeueoaoe aeine?aeaeaiiy Oaeoe/iee iaoa??ae ?iaioe neeaaea? 4 ?icae?ee. O ia?oiio ?icae?e? iiaeaia ee?i?ei-eaai?aoi?ia, a?io?i?/ia oa ?ioiieia?/ia oa?aeoa?enoeea oai?eo ia N*A aei oa i?ney e?eoaaiiy IO. O ae?oaiio ?icae?e? i?iaiae?ciaaii ?acoeueoaoe e?eoaaiiy IO o oai?eo ia ?A. O o?aoueiio ?icae?e? – ia AA. O /aoaa?oiio ?icae?e? aeeeaaeaii ?acoeueoaoe e?eoaaiiy aooi?ioiieo e?ec?a o oai?eo ia N*A oa AI. Ia?oa caaaeaiiy iaoeo aeine?aeaeaiue iieyaaei o aeyaeaii? iniaeeainoae ee?i?ei-?ioiieia?/iiai noaoono o oai?eo ia NCNO, cie?aia o eiaei?e iicieia?/i?e a?oi? (N*A, ?A. AA). Ni?eueiith ?enith a ee?i?/iiio noai? aoea aeniea aeoeai?noue ?aaiaoe/iiai i?ioeano c nenoaii?noth o?aaeaiiy, ui i?aeoaa?aeaeoaaeany aenieeie ee?i?ei-a?io?i?/ieie oa ?ioiieia?/ieie iieacieeaie. Aeyaeaii aenieee ??aaiue OIA (a 2–3 ?ace), N?A (3+), n?aeiai? eeneioe (a 1,5 ?aco), o?a?eiiaaio, a2 oa !-aeiaoe?io (a 1,5–2 ?ace). Aiae?c ci?i iieaciee?a ee?oeiii? oa aoii?aeueii? eaiee ?ioi?oaoo o ?ac? NCNO a ii??aiyii? c ii?iaeueieie iieacieeaie oa aaee/eiaie cana?ae/ea, ui aeey an?o ianoaaeaieo oai?eo ni?eueiith ?enith a ?ioiia?ai? aoei cieaeaiiy e?euee?nii?, ooieoe?iiaeueii? aeoeaiino? oa i?eai?/aiiy noi?ani?ii? ooieoe?? Oe ?acii ?c aeoeaaoe??th A-nenoaie, iecuee? ?aca?ai? iiaeeeaino? iaeo?io?eueieo a?aioeioeeo?a a INO-oano?; aenieee ??aaiue (a 2–3,5 ?aco) Oe?E oa IgG, iecueeee ??aaiue eiiieaiaioa?ii? aeoeaiino? ne?iaaoee e?ia?, ui oa?aeoa?ii aeey aooi?ioiiiai i?ioeano. Oe? ci?ie iniaeeai aoee ae?aaeai? o oai?eo ?c caaino?aiiyi i?ioeano oa ca oiia aaaeeiai ia?aa?ao caoai?thaaiiy, a naia i?e e?eciaeo noaiao. Iniaeeainoyie ?ioiii? ?aaeoeaiino? i?aai?cio caeaaeii a?ae iicieia?/ieo oi?i aoee: o oai?eo ia N*A – i?aeaeuaiiy ??aiy IgM oa aioeo?e aei AeIE; ia ?A – aenieee ??aaiue iaoaaie?/ii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a c ?o iecueeeie ?aca?aieie iiaeeeainoyie; o oai?eo ia AA – oaiaeaioe?y aei i?aeaeuaiiy IgA. Aeyaeai? ci?ie, ui i?aeoaa?aeaeoaaee aeoeai?noue aooi?ioiiiai i?ioeano, aoee i?aenoaaith aeey oe?eani?yiiaaii? ?ioiiei?eaoaaeueii? oa?ai?? iaoiaeii IO. Ieaciaoa?ac o e?eoaaii? oai?eo ia nenoaiiee /a?aiiee aia/ae Niinoa?aaeaiiy cana?ae/eee, ui e?eoaaiiy oai?eo ia NCNO aeno?aei?ii?aeueieie iaoiaeaie (IO) ia? nooo?a? ia?aaaae o ii??aiyii? c o?aaeeoe?eieie, a naia: na?aae oai?eo ia N*A IA iiceoeaiee ee?i?/iee aoaeo aeinyaiooi o 75,8%, a na?aae oai?eo EA, yeei i?iaiaeeee noaiaea?oio oa?iaeioa?ai?th, – o 54,3%. Ee?i?/ia iie?auaiiy o oai?eo ia N*A i?iyaeyeiny ciaioaiiyi aieth o noaeiaao (73,3%), aiaieuaai? aeneiee (oaiiiai noaeeiiiai iaoaeeea) (75,4%) oa aeenei?aeii? aeneiee ia oe??? (23,3%), ii?iae?caoe??th oaiia?aoo?e o?ea (66,7%), i?eieiaiiyi aa?y/ee (16,7%). O oai?eo c o?aaeaiiyi ia?aiai? nenoaie i?ney i?iaaaeaiiai e?eoaaiiy IO ciaioeany aieiaiee a?eue, i?eieieeeny caiaii?i/aiiy oa ia?anoac??, ii?iae?coaaany nii, iie?ioeany iano??e. O oai?eo ?c caaaeueiio?io?/iei neiae?iiii i?eieieeiny aeiaae?iiy aieinny, caai?eeny ae?acee a ?ioia?e ii?iaeiei?, o ?ac? neiae?iio ?aeii (53,3%) iie?ioeeany i?e?ioee?eoeyoe?y. O 16,7% oai?eo cia/ii ciaioeeany e?ioaaeaiiiao?y. O 56,7 ?c 86,7% i?eieieeeny i?iyae ea?aeeoo, a o 50,2 ?c 56,7% — i?iyae ioeueiii?oo.O oai?eo ?c ethion-iao?eoii (56,7%) cieeee ia?nenooth/a i?ioa?io??y oa a?eo?ioeeoo??y, /iai ia niinoa??aaeiny na?aae oai?eo EA. Aiaeii/an ?c ee?i?/iei iie?auaiiyi cacia/aii iiceoeaio aeeiai?eo eaai?aoi?ieo oa a?io?i?/ieo iieaciee?a aeoeaiino? i?ioeano. Oae, iaea?eueo ae?acia oa noaoenoe/ii a??ia?aeia cieaeaiiy OIA a?aecia/aii o an?o oai?eo iaio a?oi, i?ioa na?aae oai?eo IA a ii??aiyii? c EA aeeiai?ea oeueiai iieacieea aoea a?eueo cia/ouith. A?aei?/aii ii?iae?caoe?th N?A, n?aeiai? eeneioe, ??aiy o?a??iiaaio, a2 – oa g-aeiaoe?i?a. I?e oeueiio anoaiiaeaii, ui na?aae oai?eo IA cacia/ai? iieacieee aoee iaeaea aaea?/? ieae/eie, i?ae o oai?eo EA, ui i?aeoaa?aeaeo? aenieo aoaeoeai?noue IO a ii??aiyii? c o?aaeeoe?eiith oa?iaeioa?ai??th. Aiae?coth/e noai ee?oeiii? oa aoii?aeueii? eaiee ?ioi?oaoo ie ae?eoee aeniiaeo, ui IO aieeaa? ia i?aeaeuaiiy O-noi?ani?ii? aeoeaiino? Oe oa cieaeaiiy Ae, aeoea?co? ?aca?ai? iiaeeeaino? iaeo?io?eueieo a?aioeioeeo?a a INO-oano?, ni?ey? cia/iiio cieaeaiith (ao?e/?) ??aiy Oe?E, IgG ,I oa i?eai?/aiith i?iaeoeoe?? aioeo?e aei AeIE, a oaeiae i?aeaeuo? ??aaiue eiiieaiaioa?ii? aeoeaiino? ne?iaaoee e?ia?. Oe? iieacieee iiaeia aeei?enoiaoaaoe ye e?eoa??? ioe?iee aoaeoeaiino? oa?ai?? IO o oai?eo ia N*A. Ieaciaoa?ac o e?eoaaii? oai?eo ia ?aaiaoi?aeiee a?o?eo Ioe?ithth/e ?acoeueoaoe e?eoaaiiy ?A iaoiaeii IO, iiceoeaio aeeiai?eo a?aecia/aii o 81% oai?eo ?c IA i?ioe 67% oai?eo ?c EA. Oe? aeai? aoei ia’?eoea?ciaaii ia iniia? a??ia?aeiiai cieaeaiiy iieaciee?a noaeiaiaiai, caiaeueiiai oa aieueiaiai ?iaeaen?a. Ciaioeeeny ee?i?/i? i?iyae ea?aeeoo, aaneoe?oo, e?ioaaeaiiiao??; niinoa??aaeany ?aa?an?y ?aaiaoi?aeieo aoceee?a o 8 c 12 oai?eo. Aeineoue oaeaeeei ? no?eeei aoei caai?iiy o?io?/ieo ae?acie i?ney i?iaaaeaiiai eo?no IO. O 24 oai?eo c neiia?oaie ii?iae?coaaeany oaiia?aoo?a o?ea, ciaioeany iaa?ye oa aeao?ao?aoe?y noaeiaa, a?aeiiaeeany i’yciaa neea. Ocaaaeueithaaeueiee iieaciee aoaeoeaiino? e?eoaaiiy oai?eo na?ae/eoue, ui iiceoeaia ee?i?/ia aeeiai?ea na?aae oai?eo ?c IA a?aecia/aia aaea iai?ee?ioe? eo?no IO, oiae?, ye na?aae oai?eo EA ee?i?/ia aeeiai?ea aoea iacia/iith ? ooieoe?iiaeueia aeoeai?noue i?aeaeuoaaeanue o?eueee iai?ee?ioe? o?aoueiai oeaeiy e?eoaaiiy. Oae, i?iyae neiia?oo o oai?eo EA ciaioeeeny o?eueee a 1,5 ?aco, i?ioe 2,4 ?aco o oai?eo IA; aieueiaee neiae?ii — a 1,4 ?aco i?ioe 3 ?ac?a; ?aieiaa neoo?noue – a 2,3 ?aco i?ioe 3,4 ?aco o oai?eo IA. O aeiaeiiai ?c 30 oai?eo EA ia niinoa??aaeiny ?aa?an?? ?aaiaoi?aeieo aoceee?a ? o?eueee o 3 ?c 8 ii?iae?coaaeany oaiia?aoo?a o?ea. Ia io?eiaii iiceoeaii? aeeiai?ee c aieo a?noea?aeueieo i?iya?a ?A o oai?eo EA. Iaaaaeai? aeai? na?ae/aoue, ui iaeaeaa aa??aioe oa?ai?? cieaeothoue aeoeai?noue caiaeueiiai i?ioeano o oai?eo ia ?A, i?ioa canoinoaaiiy IO aoei a?eueo aoaeoeaiei. Aiae?c eaai?aoi?ieo iieaciee?a i?aeoaa?aeaeo? iiceoeaio ae?th IO o oai?eo ia ?A. Oae, noaoenoe/ii a??ia?aeiei (?<0,01) aoei cieaeaiiy OIA, N?A, na?iioei?aeo, ??aiy o?a?eiiaaio, a2- oa g-aeiaoe?i?a; iaeaea ao?e/? ciaioeany oeo? ?aaiaoi?aeiiai oaeoi?o. Iiceoeaia aeeiai?ea cacia/aieo iieaciee?a niinoa??aaeany ? o oai?eo EA, i?ioa aiia aoea iaio ae?aciith (?<0,05). Oaeei /eiii, aeyaeaia i?yia caeaaei?noue i?ae ciaioaiiyi e?eueeino? “aino?ioacieo” a?ee?a caiaeaiiy, OIA, aeeni?ioa?iai?? oa ee?i?/ieie i?iyaaie ?A, ui ua ?ac i?aeoaa?aeaeo? aoaeoeai?noue oa?ai??, yeo i?iaiaeeee. Ne?ae cacia/eoe, ui e?eoaaiiy IO ia ni?e/eieei nooo?aeo ci?i a ii?oieia?/iiio neeaae? e?ia?, ui aeiaiaeeoue aacia/i?noue eiai canoinoaaiiy. Iioei?caoe?y ?ioiieia?/ieo iieaciee?a o oai?eo ia ?A i?ney i?iaaaeaiiai eo?no IO na?ae/eoue i?i eiai ei?eaoaaeueio ae?th ye ia ee?oeiio, oae ? ia aoii?aeueio eaiee. A?aecia/aii ii?iae?caoe?th On, Oo oa ?o ni?aa?aeiioaiiy (Oo/On), cia/ii ciaioeeany aeoeaaoe?y Ae, a?aeiiaeeeny ?aca?ai? iiaeeeaino? iaeo?io?eueieo a?aioeioeeo?a a INO-oano?. Iieaciaei aoei cieaeaiiy ??aiy Oe?E (a 2 ?ace) oa IgG, IgM; ii?iae?coaaeeny i?iyae eiiieaiaioai??. O oai?eo EA iieacieee ?ioiia?aie caeeoaeeny aac nooo?aeo ci?i. Oaeei /eiii, ocaaaeueithth/e aeeeaaeaia, iiaeia c?iaeoe aeniiaie, ui aeno?aei?ii?aeueia e?eoaaiiy iaoiaeii IO caaacia/o? cia/ia iie?ioaiiy ooieoe?iiaeueii? aeoeaiino? noaeia?a o ?ac? ?A oa ei?aeoe?th ?ioiia?aie a ii??aiyii? c o?aaeeoe?eiith oa?ai??th. E??i oeueiai, IO ni?ey? cieaeaiith aeice AEN ia 20–40%, a IICI — ia 30–50%. A ie?aieo aeiaaeeao ei?oeeinoa?i?aee aoei a?aei?iaii. O aeiaeiiai oai?iai i?ae /an e?eoaaiiy IO ia niinoa??aaeiny iia?/ieo ?aaeoe?e oa neiae?iio ?eeioaoa. Ieaciaoa?ac o e?eoaaii? oai?eo ia aaii?aa?/iee aaneoe?o A?aeiii, ui a ae?aaiinoeoe? nenoaiieo aaneoe?o?a aaaeeeaa cia/aiiy ia? i?aaeeueia o?aeooaaiiy ee?i?/ieo neiioii?a, ine?eueee niaoeeo?/ieo eaai?aoi?ieo oano?a aeey oeueiai caoai?thaaiiy ia ?nio?. Oiio, aiae?coth/e aoaeoeai?noue e?eoaaiiy IO, iniiaio oaaao aoei i?eae?eaii naia aeeiai?oe? ee?i?/ieo iieaciee?a. Ie aeyaeee, ui e?eoaaiiy IO o oai?eo IA aoei iiceoeaiei o 74% i?ioe 63,4% ?c EA. I?ney i’yoiai naaino IO o oai?eo ?c ae?aceaie ieaei?o e?ioe?aie, ui o?eaaei ia caaiththoueny, a?aeaoaaeeny ?aia?aoeai? ci?ie c iiaiith a?aioeyoe??th ?ai. Iaeii/anii a?aeaoaaeany ?aa?an?y noaeiaiaiai eiiiiiaioa o 14 c 16 oai?eo oa aaaeii?iaeueiiai neiae?iio o an?o oai?eo. O iaoe??io?a ?c aeeno?io?/ieie ci?iaie i?iea?aea ciaioeany a?eue o ae?eyioe? na?oey oa i?eieieeany caaeeoea i?ae /an o?ce/ieo iaaaioaaeaiue. O oai?iai c ?cieueiaaiei iao?ioe/iei neiae?iiii ii?iae?coaaeeny iieacieee caaaeueiiai aiae?co na/? oa aiae?co ca Ia/eii?aieii. O oai?eo EA oaeiae niinoa??aaeany iiceoeaia aeeiai?ea ee?i?/ieo i?iya?a AA, i?ioa ia??iae aei ia?oeo i?iya?a oeueiai iie?auaiiy aoa cia/ii aeiaoei (o 1,5–2 ?ace a ii??aiyii? c oai?eie IA). O 1/3 oai?eo no?eei caa??aaany noaeiaiaee neiae?ii. Ii?yae ?c iiceoeaiith ee?i?/iith aeeiai?eith iiaa?oaeeny aei ii?ie ? eaai?aoi?i? iieacieee, a naia: a??ia?aeii cieaeoaaeeny OIA, e?euee?noue eaeeioeeo?a, N?A, aaia-aeiaoe?ie, ioeii?ioa?aee oa ??aaiue o?a?eiiaaio e?ia?. O oai?eo EA eaai?aoi?i? iieacieee ci?ithaaeeny iaa??ia?aeii. Aiae?coth/e ?ioiieia?/iee neeaae e?ia? i?ney IO, ie aeyaeee cia/ia (?<0,01) cieaeaiiy Oe?E, IgA, i?aeaeuaiiy On oa a?aeiiaeaiiy ?aca?aieo iiaeeeainoae iaeo?io?eueieo a?aioeioeeo?a. O oai?eo EA ?ioiia?aia caeeoaeany aac ci?i. Oaeei /eiii, i?aeoaa?aeaeaii aoaeoeai?noue canoinoaaiiy IO o oai?eo ia AA o ii??aiyii? c? noaiaea?oiith oa?iaeioa?ai??th. Ioeuen-oa?ai?y a eiia?iaoe?? c ieaciaoa?acii o e?eoaaii? aooi?ioiieo e?ec?a Iniaeeao caoe?eaaeai?noue o iaoeo aeine?aeaeaiiyo aeeeeeaei e?eoaaiiy aooi?ioiieo e?ec?a, ye? aeieeee aiane?aeie aeniei? aeoeaiino? aooi?ioiiiai i?ioeano o oai?eo ia N*A oa AI. Aia/aeiaee e?ec noi?iaiaeaeoaaany aenieith oaiia?aoo?ith o?ea (aeua ca 38° N), nooaeiaiiyi (aei 9 ea), ae?aceiai-iae?ioe/iei noiiaoeoii oa o?aaeaiiyi o?aaiiai o?aeoo. O 4 oai?eo ae?aaiinoiaaii aino?ee i?iea?aeeo, o 19 — ethion-iao?eo c ai?eaioeoi?iieie iaiaaeaie. Aiaeii/an i?iyae e?eco noi?iaiaeaeoaaeeny aenieeie iieacieeaie “aino?ioacieo” a?ee?a, aiai??th, eaeeiiai??th, o?iiaioeeoiiai??th, iayai?noth LE-ee?oei. O oai?eo c ie?eiaei neiae?iiii niinoa??aaeany ianeaia i?ioa?io??y (a?eueoa ca 3 a/e), aineia? oa a?ae?iia? oeee?iae?e. E??i oeueiai, cia/i? ii?ooaiiy niinoa??aaeeny ? a ?ioiia?ai?: ao?e/? aoa i?aeaeuaiee ??aaiue Oe?E, oaea?/? IgG oa oeo? aioeo?e aei AeIE. I?ney i?iaaaeaiiai ?ioaineaiiai e?eoaaiiy IO iaoeei?aaei?cieiiii o eiia?iaoe?? c eo?nii IO e?ec aoei eoi??oaaii i?aeoe/ii o an?o (21) oai?eo. Oaiia?aoo?a o?ea cieceeany aei noaoaa?eeueieo iieaciee?a, ii?iae?coaaany ?eoi na?oeaai? ae?yeueiino?, i?aeaeueeany cao/i?noue oii?a na?oey. O oai?eo c o?aaeaiiyi ie?ie onoiaii ?ecee ?icaeoeo ie?eiai? iaaeinoaoiino?. I?eai?/aiiy aino?ioe e?eco i?aeoaa?aeaeoaaeiny eaai?aoi?ieie iieacieeaie: a??ia?aeii cieceeeny OIA, N?A, iieacieee n?aeiai? i?iae, a2- oa g-aeiaoe?i?a, ??aaiue o?a?eiiaaio, i?aeaeueeany e?euee?noue eaeeioeeo?a oa o?iiaioeeo?a, ao?e/? ciaioeeany e?euee?noue LE-ee?oei. O oai?eo ?c iao?ioe/iei neiae?iiii ii?iae?coaaeeny iieacieee na/? ca Ia/eii?aieii oa Ceiieoeueeei. Iniaeeai iieaciaith aoea aeeiai?ea ?ioiia?aie: a??ia?aeii cieceany ??aaiue Oe?E, IgG oa aioeo?e aei aeAeIE, ui aeicaiey? i?iaiicoaaoe iiaeaeueoee ia?aa?a caoai?thaaiiy. Iiceoeaiee e?eoaaeueiee aoaeo IO c IO niinoa??aaany o oai?eo ia AI. Ca 12 aei?a ?ioaineaiiai e?eoaaiiy o oai?eo cieeee i?aea??, ciaioeeeny a ?ici??ao e?ioaoe/i? aocee, ii?iae?coaaeany oaiia?aoo?a o?ea, caai?eeny ae?acee ia aii?eeao. A??ia?aeii ii?iae?coaaeeny eaai?aoi?i? iieacieee e?ia?. O aeeiai?oe? ?ioiia?aie a?aecia/aii ii?iae?caoe?th aoii?aeueii? eaiee ?ioi?oaoo, oiae? ye ee?oeiia eaiea ia ci?ithaaeany. Oaeei /eiii, ?ioaineaia e?eoaaiiy IO a eiia?iaoe?? c IO ni?eyei eoi??oaaiith e?eciaiai noaio, ui i?aeoaa?aeaeoaaeiny ee?i?ei-eaai?aoi?ieie oa ?ioiieia?/ieie iieacieeaie. AENIIAEE 1. Aiae?c noaio ?ioiia?aie o oai?eo ia NCNO aea? i?aenoaae aeae?eeoe ni?euei? ?ene aeey an??? ianoaaeaii? a?oie: aenieee ??aaiue Oe?E, IgG, eiiieaiaioai?th, cieaeaiiy noi?ani?ii? aeoeaiino? Oe, aeenooieoe?th iaeo?io?eueieo a?aioeioeeo?a c iecueeeie ?aca?aieie iiaeeeainoyie a INO-oano?. Aiaeii/an aeae?eaii iniaeeaino? ?ioiiiai noaoono i?e ie?aieo iicieia?/ieo oi?iao. Oae, o oai?eo ia N*A a?aecia/aii aenieee ??aaiue aioeo?e aei AeIE, o oai?eo ia ?A – aenieee ??aaiue IgG ia oii? iaoaaie?/ii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a oa ?o iecueeeo ?aca?aieo iiaeeeainoae, o oai?eo ia AA – oaiaeaioe?th aei i?aeaeuaiiy IgA. 2. Canoinoaaiiy IO c AEN o oai?eo ia NCNO ni?ey? cieaeaiith aeoeaiino? aooi?ioiiiai i?ioeano, ui ae?aaea?oueny cia/iei cieaeaiiyi OIA, N?A, iieaciee?a n?aeiai? i?iae, na?iioei?aeo, a2- oa g-aeiaoe?i?a, ??aiy o?a?eiiaaio, e?eueeino? LE-ee?oei, oeo?o aioeo?e aei AeIE, ca?eueoaiiyi eiiieaiaioo o ne?iaaooe? e?ia?. 3. Aea/aiiy ae?? IO ia ?ioiieia?/iee neeaae e?ia? o oai?eo ia NCNO na?ae/eoue i?i eiai ei?eaoaaeueio ae?th ye ia ee?oeiio, oae ? ia aoii?aeueio eaiee ?ioi?oaoo. 4. Cai?iiiiiaaia iaie noaia i?iaaaeaiiy IO aeicaiey? io?eiaoe iiceoeai? ee?i?ei-?ioiieia?/i? ?acoeueoaoe o 75,8% oai?eo ia N*A, o 81% — ia ?A, o 74% — ia AA; oieeiooe ?icaeoeo aooi?ioiieo e?ec?a, a oaeiae i?aeaeueoe oiea?aioi?noue aei AEN oa IICI. 5. Aeeth/aiiy aei e?eoaaiiy eiia?iaoe?? IO iaoeei?aaei?cieiiii ? IO aeicaiey? caaaeueioaaoe aooi?ioiiee e?ec oa oieeiooe ie?eiai? iaaeinoaoiino?, aooi?ioiii? iaioeeoiiai??, caiia?aoe o?aaeaiith oeaio?aeueii? ia?aiai? nenoaie o oai?eo ia N*A oa AI. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeioe?eueii aeei?enoiaoaaoe ianooii? e?eoa??? a?aeai?o oai?eo ia NCNO aeey i?iaaaeaiiy IO: — II–III nooi?iue aeoeaiino? i?ioeano; — nenoaii?noue o?aaeaiiy (ie?ie, oeaio?aeueii? ia?aiai? nenoaie, iayai?noue aooi?ioiiiai aaiaoieia?/iiai neiae?iio); — ?acenoaioi?noue aei iiia?aaeiuei? oa?ai?? IICI oa AEN; — oneeaaeiaiiy i?ney o?eaaeiai i?eeiio AEN. 2. O ?ac? iaeneiaeueiiai nooiaiy aeoeaiino? c ?icaeoeii aooi?ioiiiai e?eco iaiao?aeii i?ecia/aoe eiia?iiaaia e?eoaaiiy ?c canoinoaaiiyi IO ei?oeeinoa?i?aeaie oa IO. 3. O ?ac? e?eoaaiiy oai?eo ia NCNO iaoiaeii IO oa IO o ii?aeiaii? c IO iaiao?aeii caa??aaoe iiia?aaeith iaoiaaiaoe/io oa?iaeioa?ai?th a aaeaeaaoieo aeicao. 4. C iaoith caiia?aaiiy “rebaund”-aoaeoo i?ae /an naaino IO aeioe?eueiei ? aaaaeaiiy aioo??oiueiaaiii aaeaeaaoieo aeic AEN caeaaeii a?ae nooiaiy aeoeaiino? i?ioeano. NIENIE IIOAE?EIAAIEO I?AOeUeCA OAIITH AeENA?OAOe?? 1. I?ioeaiei A.A. Aooaeoeaiinoue eioaineaiie oa?aiee nenoaiiie e?aniie aie/aiee n e?eciaui oa/aieai. //Oe?. ea?ae?ie. aeo?iae. — 1997. — Aei. 2, ? 2. – N.78–79. 2. I?ioeaiei A.A., Ai?oeaae/ I.I., Aieiaeia TH.AE. E?eoa?ee ioai?a e i?iaaaeaieth ieaciaoa?aca aieueiuo ?aaiaoieaeiui a?o?eoii ia iniiaa ioeaiee ninoiyiey einoiie oeaie ii aeaiiui aeaineoiiao?ee. // Oe?. ea?ae?ie. aeo?iae. — 1997. – Aei. 2, ? 2. — N.80–81. 3. Eiaaeaiei A.I., I?ioeaiei A.I., Eeoaiaa A.O. Aoaeoeai?noue ioeuen-oa?ai?? nieth-iaae?ieii o oai?eo ia ?aaiaoe/i? caoai?thaaiiy. //Ee?i?/ia oa?iaoe?y. — 1997. – O. 1, ? 1. — N. 18–19. 4. I?ioeaiei A.A. I?eiaiaiea ieaciaoa?aca a eiiieaeniii ea/aiee ?aaiaoieaeiiai a?o?eoa. //Oe?. ea?ae?ie. aeo?iae. — 1998. – ? 9. – N.74–75. 5. I?ioeaiei A.I. Iaoiaee/i? aniaeoe aeno?aei?ii?aeueieo iaoiae?a e?eoaaiiy a ?aaiaoieia??. // Iaoa??aee iaoeiaeo i?aoeue II Iaoe?iiaeueiiai Eiia?ano ?aaiaoieia?a Oe?a?ie.– Ee?a. — 1997. – N. 23–24. 6. I?ioeaiei A.I. Aieea ieaciaoa?aco ia ee?i?ei-?ioiieia?/i? iieacieee o oai?eo ia aaii?aa?/iee aaneoe?o.//Iaoa??aee iaoeiaeo i?aoeue II Iaoe?iiaeueiiai Eiia?ano ?aaiaoieia?a Oe?a?ie. — Ee?a. — 1997. — N.76–77. 7. I?ioeaiei A.I. Iioeiaeaeaiiy oeoieiai-eeoeiaiai o?aeoo o oai?eo ia aea?iaoii?iceo.//Iaoa??aee iaoeiaeo i?aoeue II Iaoe?iiaeueiiai Eiia?ano ?aaiaoieia?a Oe?a?ie.- Ee?a. — 1997. — N.77–78. 8. I?ioeaiei A.I., I?e?oi?iaa E.I., Ia?’yi E.A., Einoth/aiei O.I. Aieea ieaciaoa?aco ia ?ioiieia?/i? iieacieee e?ia? o oai?eo ia ?aaiaoi?aeiee a?o?eo.//Iaoa??aee iaoeiaeo i?aoeue II Iaoe?iiaeueiiai Eiia?ano ?aaiaoieia?a Oe?a?ie. — Ee?a. — 1997. – N.105. 9. Aaeeoeeay A.E., I?ioeaiei A.A. Eioaineaiay oa?aiey nenoaiiie e?aniie aie/aiee. //Oe?. ea?ae?ie. aeo?iae. — 1995. – ?1 (aeiaeaoie).– N.66. 10. Ooaa I.I., I?ioeaiei A.A. Aeeiaieea eiioiieiae/aneeo iieacaoaeae i?e ea/aiee aieueiuo nenoaiiie e?aniie aie/aieie n aooieioiiui e?ecii. //Oe?.ea?ae?ie.aeo?iae. — 1995. – ?1 (aeiaeaoie). – N.77. 11. Aaeeoeeay A.E., I?ioeaiei A.A., Iaaeaiei A.I. I?eiaiaiea ieaciaoa?aca o aieueiuo aaii??aae/aneei aaneoeeoii.//Iaoa?eaeu ?anioaeeeaineiai neiiiceoia “Aeooaeueiua aii?inu ?aaiaoieiaee”. – Iaeanna. — 1995. – N.22-23. 12. I?ioeaiei A.A. Aiaeec ioaeaeaiiuo ?acoeueoaoia eiiieaeniiai i?eiaiaiey ieaciaoa?aca e ioeuen-oa?aiee o aieueiuo nenoaiiie e?aniie aie/aieie. //Iaoa?eaeu ?anioaeeeaineiai neiiiceoia “Aeooaeueiua aii?inu ?aaiaoieiaee”. — Iaeanna. — 1995. — N.89. 13. Eiaaeaiei A.I., Aaeeoeueea A.E., Cai?oaenueea A.TH., I?ioeaiei A.I. Ioe?iea aoaeoeaiino? ieaciaoa?aco o oai?eo ia nenoaiiee /a?aiiee aia/ae. //Oac. aeii. I Eiia?ano ?aaiaoieia?a Oe?a?ie. – Oa?iii?eue. – 1993. – N.55–56. 14. Aaeeoeeay A.E., Eiaaeaiei A.I., Ooaa I.I., Noeoaiiaa O.AE., I?ioeaiei A.A., Ai?oeaae/ A.I., Iaouoeeee A.E. Ii?aaeaiea ieiea?aea o aieueiuo nenoaiiie e?aniie aie/aieie. //Oac. aeii. iaoeiai-i?aeoe/. eiio. “No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”. — Aeiiaoeuee. — 1996. – N. 9. 15. I?ioeaiei A.A. Aeeiaieea eeeieei-aeioeie/aneeo iieacaoaeae e?iae o aieueiuo ?aaiaoieaeiui a?o?eoii iinea eiiaeie?iaaiiie eioaineaiie oa?aiee.//Oac.aeii. iaoeiai-i?aeoe/. eiio.”No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”. — Aeiiaoeuee. —1996. – N. 48. 16. I?ioeaiei A.A., Ieeeoi?iaa E.I., Ia?ueyi E.A., Einoth/aiei O.I., Iaianthe O.I. Eiiaeie?iaaiiia eniieueciaaiea ieaciaoa?aca e ioeuen-oa?aiee o aieueiuo ?aaiaoieaeiui a?o?eoii. //Oac.aeii. iaoeiai-i?aeoe/. eiio.”No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”.— Aeiiaoeuee.—1996. – N. 48-49. 17. I?ioeaiei A.A. N?aaieoaeueiay ioeaiea yooaeoeaiinoe ieaciaoa?aca e eiiaeie?iaaiiiai ea/aiey ieaciaoa?aca n ioeuen-oa?aieae o aieueiuo caaieaaaieyie niaaeeieoaeueiie oeaie. //Oac.aeii. iaoeiai-i?aeoe/. eiio. ”No/ania e?eoaaiiy ?aaiaoe/ieo caoai?thaaiue”. — Aeiiaoeuee. — 1996. — N. 49. 18. Ooaa I.I., Eiaaeaiei A.I., I?ioeaiei A.I. E?eoaaiiy aooi?ioiieo e?ec?a o oai?eo ia nenoaiiee /a?aiiee aia/ae oa aoceeeiaee ia?ea?oa???o. // Oac. aeii. VI Eiia?ano na?oiai? oaaea?aoe?? oe?. e?ea?. oiaa?enoa. — Iaeana. — 1996. – N. 192. 19. Galitskaya A.K., Gavrilenko T.I., Protsenko G.A. Immunological findings in patients with sistemic lupus erythematosus (SLE) treated by pulsetherapy (PT) and plasmapheresis (PE). //Revista de reumatologie. – 1996.- Vol. IV. - P.93. 20. Kovalenko V., Shuba N., Galitskaya A., Terzov A., Protsenko G. Clinical assesment of patients with systemic lupus erythematosus associated with the complement deficiency. //Rheumatology in Europe.- 1995.- ?2.- P.349. AIIOAOe?ss I?ioeaiei A.I. ?ioaineaia oa?ai?y ?aaiaoe/ieo caoai?thaaiue c aooi?ioiiei oa ?ioiieiiieaeniei iaoai?ciii ?icaeoeo.-?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.12. – ?aaiaoieia?y. Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea IIC Oe?a?ie, Ee?a, 1998. I?iaaaeai? aeine?aeaeaiiy i?enay/ai? ?ic?iaeaiith iiaeo e?eoa???a a?aeai?o oai?eo ia NCNO aeey ?ioaineaii? oa?ai?? iaoiaeii ieaciaoa?aco c aetheiei?oeeinoa?i?aeaie oa eiia?iaoe?? ioeuen-oa?ai?? c ieaciaoa?acii c o?aooaaiiyi aeo?aeiiai ?ioiiiai noaoono (ee?oeiii? oa aoii?aeueii? eaiee). Anoaiiaeaii, ui aenie? iieacieee Oe?E, IgG, i?eai?/aiiy noi?ani?ii? aeoeaiino? O-e?ioioeeo?a, iecuee? ?aca?ai? iiaeeeaino? iaeo?io?eueieo a?aioeioeeo?a a INO-oano? iiaeooue aooe aeiaeaoeiaeie e?eoa??yie aeey i?ecia/aiiy aeno?aei?ii?aeueiiai e?eoaaiiy. ?ic?iaeaii ee?i?ei-eaai?aoi?i? oa ?ioiieia?/i? e?eoa??? aoaeoeaiino? ieaciaoa?aco oa ioeuen-oa?ai?? c ieaciaoa?acii o oai?eo ia NCNO. Eeth/ia? neiaa: nenoaiiee /a?aiiee aia/ae, ?aaiaoi?aeiee a?o?eo, aaii?aa?/iee aaneoe?o, aoceeeiaee ia??a?oa???o, ieaciaoa?ac, ioeuen-oa?ai?y. SUMMARY Protsenko G. Intensive cure of rheumatic diseases with autoimmune and immunocomplex mechanisms.-Manuscript. Dissertation for obtaining of scientifical degree of candidate of medical sciences in 14.01.12 – rheumatology.- Ukrainian research institute Healthy Ministry of Ukraine, Kiev, 1998. The investigation is devoted to the elaboration of new criteria for selection patients with systemic connective tissue disorders (SCTD) for intensive cure by the methods of plasmapheresis (RA) and pulsetherapy (PT) with accounting of basic immune state (cellular and humoral links). It was determined, that high levels of circulating immune complexes, immunoglobulins G, as well as decrease in activity of T-lymphocytes and low reserve possibilities of neutrophiles by NBT-test-all of them may be additional criteria for prescription of extracorporal methods of treatment. The were elaborated clinical, laboratory and immunological creteria of PA and PA with PT efficacy in SCTD-patients. Key words: systhemic lupus erythematosus, rheumatoid arthritis, vasculitis haemorragica, polyarteritis nodosa, plasmapheresis, pulsetherapy. AIIIOAOeEss I?ioeaiei A.A. Eioaineaiay oa?aiey ?aaiaoe/aneeo caaieaaaiee n aooieioiiui e eioiieiiieaeniui iaoaieciii ?acaeoey.-?oeiienue Aeena?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.12. – ?aaiaoieiaey. Oe?aeineee iao/ii-enneaaeiaaoaeueneee einoeooo ea?aeeieiaee ei. aeaae. I.Ae.No?aaeanea IIC Oe?aeiu, Eeaa, 1999. ?aaioa iinayuaia aeooaeueiie oaia – eco/aieth yooaeoeaiinoe eioaineaiiai ea/aiey aieueiuo NCNO (NEA, ?A, AA, OI) n eniieueciaaieai ieaciaoa?aca n aetheiei?oeeinoa?ieaeaie e eiiaeiaoeee ioeuen-oa?aiee n ieaciaoa?acii, a oaeaea ?ac?aaioea iiauo e?eoa?eaa ioai?a aieueiuo NCNO aeey aeaiiuo iaoiaeia ea/aiey n o/aoii enoiaeiiai eiioiiiai noaoona (eeaoi/iiai e aoii?aeueiiai caaia). Ianeaaeiaaa 107 aieueiuo NCNO (IA), auee ii?aaeaeaiu e?eoa?ee aeey iacia/aiey yeno?aei?ii?aeueiiai ea/aiey iaoiaeii IO n aetheiei?oeeinoa?ieaeaie: II–III noaiaie aeoeaiinoe i?ioeanna, nenoaiiinoue ii?aaeaiey, ?acenoaioiinoue e i?aaeoanoaothuae oa?aiee, iaee/ea i?ioeaiiieacaiee e iacia/aieth IIAI eee AEN, a oaeaea ineiaeiaiee, naycaiiuo n eo aeeeoaeueiui i?eaiii. Ieaciaoa?ac i?iaiaeeee eo?nii 5-6 i?ioeaaeo? /a?ac aeaiue n ecaea/aieai 1,5–2 e ieaciu. Aeey i?ioeeaeoeee neiae?iia ?eeioaoa ai a?aiy ieaciicaiauaiey aaiaeeee aaeaeaaoiua aeicu ai?iiiia. Aieueiui n iaeneiaeueiie noaiaiueth aeoeaiinoe n ?acaeoeai aooieiioiiiai e?eca iacia/aee eiiaeie?iaaiiia ea/aiea n aeeth/aieai ioeuen-oa?aiee nieth-iaae?ieii ii 1000 ia o?e aeiy iiae?yae n iineaaeothuei i?iaaaeaiea ieaciaoa?aca ii auoaoeacaiiie noaia. Yooaeo io i?iaaaeaiiiai ea/aiey iaoiaeii IO iaaethaeaeny o 75% aieueiuo NEA, o 81% - ?A, o 74% - AA e i?iyaeyeny oiaiueoaieai aeoeaiinoe i?ioeanna (cia/eoaeueiui nieaeaieai NIY, N?A, iieacaoaeae neaeiaie i?iau e na?iioeieaea, a-2 e g-aeiaoeeiia, o?iaiy oea?eiiaaia). Eco/aiea aeaenoaey IO ia eiioiieiae/aneee ninoaa e?iae o aieueiuo NCNO iicaieyao iiaeoaa?aeaeaoue aai ei??eae?othuaa aeaenoaea eae ia eeaoi/iia, oae e ia aoii?aeueiia caaii. Onoaiiaeaii, /oi aunieea iieacaoaee OeEE, IgG, oaiaoaiea noi?anni?iie aeoeaiinoe O-eeioioeeoia, ieceea ?aca?aiua aiciiaeiinoe iaeo?ioeeueieo a?aioeioeeoia a INO-oanoa iiaoo neoaeeoue aeiiieieoaeueiuie e?eoa?eyie aeey iacia/aiey yeno?aei?ii?aeueiiai ea/aiey. Aeeth/aiea a i?ia?aiiiia ea/aiea eiiaeiaoeee IO iaoeei?aaeiecieiiii n IO iicaieyao a oa/aiea ei?ioeiai n?iea eoie?iaaoue aooieiioiiue e?ec o aieueiuo NEA e OI, ecaaaeaoue ii/a/iie iaaeinoaoi/iinoe, aooieiioiiie iaioeeoiiaiee, a oaeaea ii?aaeaiey oeaio?aeueiie ia?aiie nenoaiu. Eeth/aaua neiaa: nenoaiiay e?aniay aie/aiea, ?aaiaoieaeiue a?o?eo, aaii??aae/aneee aaneoeeo, ocaeeiaue ia?ea?oa?eeo, ieaciaoa?ac, ioeuen-oa?aiey. IA?AE?E OIIAIEO IICIA*AIUe Ae - A-e?ioioeeoe AI - aoceeeiaee ia??a?oa???o AA - aaii?aa?/iee aaneoe?o AEN – aetheiei?oeeinoa?i?aee aeAeIE – aeaiaoo?iaaia AeIE iAeIE – iaoeaia AeIE IICI – ianoa?i?aei? i?ioecaiaeuei? i?aia?aoe INO-oano – i?o?inei?-oao?acie??aee oano IO – ioeuen-oa?ai?y IO – ieaciaoa?ac ?A – ?aaiaoi?aeiee a?o?eo N*A – nenoaiiee /a?aiiee aia/ae NCNO – nenoaii? caoai?thaaiiy niieo/ii? oeaieie Oe – O-e?ioioeeoe On – O –noi?ani?e Oo – O-oaeia?e Oe?E – oee?eoethth/? ?ioii? eiiieaene Ig – ?ioiiaeiaoe?ie

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