.

Інфаркт міокарда і зміни функціонально зв’язаних білків сироватки крові: Автореф. дис… канд. мед. наук / І.І. Перескокова, Крим. держ. мед. ун-т ім.

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I?I?NOA?NOAI IOI?IIE CAeI?IA”ss OE?A?IE

E?EINUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?I.N.?.AAI?A??ANUeEIAI

IA?ANEIEIAA ?IAA ?AI??AIA

OAeE: 616-005.8 + 616.127.73+ 616.153.96

?IOA?EO I?IEA?AeA ? CI?IE OOIEOe?IIAEUeII CA”ssCAIEO

A?EE?A NE?IAAOEE E?IA?

14.01.11- EA?Ae?IEIA?ss

AAOI?AOA?AO

AeENA?OAOe?? IA CAeIAOOOss IAOEIAIAI NOOIAIss

EAIAeEAeAOA IAAeE*IEO IAOE

N?IOA?IIIEUe, 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.N.?.Aai?a??anueeiai.

Iaoeiaee ea??aiee: aeieoi? iaaee/ie[ iaoe, i?ioani? EOAEOE?I

AIEIAeEIE? OAAeI?IAE*, E?einueeee aea?aeaaiee

iaaee/iee oi?aa?neoao ?i.N.?.Aai?a??anueeiai,
caa?aeo-

th/ee eaoaae?ith aini?oaeueii? oa?ai?? ? 1.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? OAAOeUe

IAOAE?ss ?AAI?AIA, Ee?anueea iaaee/iay
aeaaeai?y

i?neyaeeieiiii? ina?oe ?i. I.E.Ooi?ea,

caa?aeoth/a eaoaae?ith oa?ai??

aeieoi? eaaee/ieo iaoe, i?ioani? EOCIAOeIA

IEEIEA NOAIAIIAE*, E?einueeee aea?aeaaiee

iaaee/iee oi?aa?neoao
?i.N.?.Aai?a??anueeiai,caa?aeo-

th/ee eaoaae?ith aini?oaeueii? oa?ai?? ?
2.

I?ia?aeia i?aai?caoe?y- Oe?a?inueeee IAe? ea?ae?ieia??
?i.I.Ae.No?aaeanea

I?i?noa?noaa ioi?iie caei?ia”y Oe?a?ie,
i.Ee?a

Caoeno a?aeaoaeaoueny ”20” ea?oiy 1999 ?ieo i _14_ aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 52. 600. 01 E?einueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i.N.?.Aaia??anueeiai (333006, i. N?ioa?iiieue,
aoe. Eai?ia 5/7).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N. ?. Aai?a??anueeiai (333006,
i. N?ioa?iiieue, aoe. Eai?ia 5/7).

Aaoi?aoa?ao ?ic?neaii”20” aa?aciy 1999 ?ieo.

O/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani? I. O.
Iaco?aoeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

Aeooaeuei?noue oaie.

Oe?iea iioe?aiiy ?oai?/ii? oai?iae na?oey (?ON) , a oaeiae aeniea
nia?oi?noue a?ae ?ioa?eoo i?iea?aea (?I) in?a i?aoeacaeaoiiai a?eo
noaaeyoue a ?yae aeooaeueieo i?iaeai ?aiith ae?aaiinoeeo, ioe?ieo
ia?aa?ao, oneeaaeiaiue ? iiaeaeueoiai i?iaiico i?e ?I (Iaea?aae/
O.TH.,1997; Aia?ia A.A., 1998). O?oaeiiu? aeeoa?aioe?aeueii?
ae?aaiinoeee ?I o oai?eo c iaoei?/iith ee?i?/iith oa
aeaeo?iea?ae?ia?ao?/iith ea?oeiith caoai?thaaiiy aeoea?coaaee iiooee
a?io?i?/ieo e?eoa???a ooeiaeaeaiiy i?iea?aea, ye? aeicaieythoue
aecia/eoe ??ci? aoaie eiai ?icaeoeo. A inoaii? ?iee iniaeeao oaaao
i?eaa?oathoue iiaeeeaino? iii?oi?oaaiiy a?eeiaiai i?io?eth oai?iai, oae
ye aiii iiaea aooe aeei?enoaii ia o?eueee aeey ae?aaiinoeee, aea ? aeey
aecia/aiiy i?iaiico (Ei?i/eei E.I., I?eiaa I.A.,1990; Aiaaiaeeia
I.TH.,AEo?aaeaaa E.A.,1990).

A?aoiaoth/e iie?ooieoe?iiaeuei?noue a?ee?a, o?nio ooieoe?iiaeueio
caeaaei?noue i?ae ie?aieie a?eeaie, ia i?aenoaa? ?o aea/aiiy iiaeia
ioa?aeoa?ecoaaoe ye noai i?aai?cio a oe?eiio, oae ? oa?aeoa?, nooi?iue
oyaeeino?, i?iaiic eiie?aoiiai caoai?thaaiiy. I?e oeueiio, /ei a?eueoa
e?euee?noue aeine?aeieo a?ee?a,oei a?eueoa eiia??i?noue ciaeoe iaae?ei?
e?eoa??? ioe?iee. Iiaeeea?noue ia??ai? c ae?aaiinoeeith caoai?thaaiiy
neeanoe oyaeaiiy i?i ae?aaeai?noue aeano?oeoeaieo ? ?aia?aoeaieo
i?ioean?a o i?iea?ae? ia? aaeeea i?aeoe/ia cia/aiiy aeey i?iaaaeaiiy
e?eoaaeueieo caoiae?a oa i?aai?caoe?? aeeoa?aioe?eiaaiiai i?aeoiaeo aei
?aaa?e?oaoe?? oai?eo.

Ca”ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa ? /anoeiith ieaiiai? iaoeiai-aeine?aeii? ?iaioe
eaoaae?e aini?oaeueii? oa?ai?? ? 1 E?einueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i.N.?.Aai?a??anueeiai (iiia? aea?aeaaii? ?a?no?aoe?? 0198U
016039).

Iaoa ? caaea/? aeine?aeaeaiiy.

I?iaiae?coaaoe aca?iica”ycee i?ae ee?i?/iei ia?aa?aii, i?iaiicii ?I ?
oa?aeoa?ii ci?ie ie?aieo a?eeiaeo nenoai i?aai?cio ia i?aenoaa? aea/aiiy
a?ee?a ne?iaaoee e?ia? oai?eo ia ?I c iaoith iie?ioaiiy ae?aaiinoeee oa
?aaa?e?oaoe?? ?ioa?eoo i?iea?aea.

Caaea/? aeine?aeaeaiiy:

1. O oai?eo ia ?I ??ciiai iioe?aiiy, aeeaeie oa eieae?caoe?? aea/eoe
??aaiue a?ee?a-?aaeoaio?a aino?i? oace, aioeieneaeaioiiai caoenoo,
o?anii?oieo a?ee?a, ?ioiiaeiaoe?i?a,a?ee?a eiiieaiaioo iniiaieo
?ia?a?oi??a i?ioa?iac.

2. I?iaanoe aiae?c ci?ie ie?aieo a?ee?a, ?o ca”yceo c ee?i?/iei
ia?aa?aii ? i?iaiicii ?ioa?eoo i?iea?aea.

3. Aeae?eeoe e?eoa??? ioe?iee ae?aaeaiino? aeano?oeoeaieo ? ?aia?aoeaieo
i?ioean?a ia i?aenoaa? aea/aiyy aeeiai?ee a?ee?a o ne?iaaooe? e?ia?
oai?eo ia ?ioa?eo i?iea?aea.

4. I?inoaaeeoe aeeiai?eo ci?ie eiioeaio?aoe?? a?ee?a ne?iaaoee e?ia? o
oai?eo ia ?I a caeaaeiino? a?ae i?iaaaeaii? oa?ai??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

I?iaaaeai? aeine?aeaeaiiy aeicaieeee anoaiiaeoe aenieo ae?aaiinoe/io
oe?ii?noue aecia/aiiy ?yaeo aeine?aeieo a?ee?a o ?iciaaeoaaii?
aeeno?io?/ieo ? iae?ioe/ieo i?ioean?a o i?iea?ae?.

Aeyaeaia caeaaei?noue ci?ie ??ai?a oea?oeiieacieio (OeI), o?ainoa?eio
(OO),aaioiaeia?io (AI), aeueoa-1-?ia?a?oi?a i?ioa?iac (aeueoa-1-?I),
aeueoa-2-iae?iaeiaoe?io (aeueoa-2-IA), aeueaoi?io (A), aeueoa-1-eeneiai
ae?eii?ioa?io (aeueoa-1-EA), ?ioiiaeiaoe?io A (IgA), N3 ? N4 eiiiiiaio?a
nenoaie eiiieaiaioo (N3 ? N4) a?ae oyaeeino? ia?aa?ao caoai?thaaiiy.

Aeyaeaii cieaeaiiy eiao?oe??io?a OeI/OO, ? aeueoa-1-?I/ aeueoa-2-IA i?e
iani?eyoeeaiio ia?aa?ao caoai?thaaiiy, ui iiaea neoaeeoe i?iaiinoe/iith
iciaeith ? aeei?enoiaoaaoeny aeey aecia/aiiy e?eoaaeueii? oaeoeee.
Cao?eniaaia ?aeaioe/i?noue ci?ie a?eeiaiai niaeo?o a a?oiao oai?eo,
oyaee?noue ia?aa?ao ?I o yeeo aecia/aeany ??cieie e?eoa??yie.

I?aeoe/ia oe?ii?noue ?iaioe.

Ai?iaaaeaeaiiy a i?aeoeeo aeine?aeaeaiue ii aecia/aiith eiioeaio?aoe??
aeine?aeieo a?ee?a o ne?iaaooe? e?ia? oai?eo iiaea aooe oe?iiei i?e
ae?aaiinoeoe? ?I ? aeeoa?aioe?aeuei?e ae?aaiinoeoe? ??cieo oi?i
?oai?/ii? oai?iae na?oey, a oaeiae aeicaiey? ioe?ieoe ae?aaeai?noue
aeano?oeoeaieo ? ?aia?aoeaieo i?ioean?a a i?aai?ci?, ui aea?
iiaeeea?noue aeeoa?aoe?eiaaii i?aeoiaeeoe aei e?eoaaiiy ? ?aaa?e?oaoe??
oai?eo ia ?I. ?ic?iaeai? e?eoa??? iiaeaeueoiai ia?aa?ao caoai?thaaiiy,
ye? iathoue i?iaiinoe/ia cia/aiiy, oea ni?ey? nai?/aniiio aianaiith
ei?aeoea o ieai e?eoaaiiy oai?iai ia ?I. Ia i?aenoaa? iii?oi?oaaiiy
a?eeiaiai i?io?eth a?oi oai?eo ia ?I i?aeoaa?aeaeaia iaa?oioiaai?noue
ee?i?/ieo e?eoa???a oyaeeino? ?I.

Iniaenoa o/anoue aaoi?a a ?ic?iaoe? iniiaieo iieiaeaiue aeena?oaoe??.

?iaioa aeeiiaia ia eaoaae?ao aini?oaeueii? oa?ai?? ? 1 (caa?aeoth/ee-
aeieoi? iaaee/ieo iaoe, i?ioani? A.O.Eoaeoe?i) ? a?ieia?/ii? o?i??
(caa?aeoth/ee- aeieoi? iaaee/ieo iaoe, i?ioani? ?.O.E??tho?i)
E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.N.?.Aai?a??anueeiai
ia aac? ?ioa?eoiiai a?aeae?eaiiy 6-i? i?nueei? ee?i?/ii? e?ea?i?
i.N?ioa?iiiey, E?einueeiai ?anioae?eainueeiai ea?ae?ieia?/iiai
aeeniaina?o. Iniiaiee ianya ee?i?/ieo, a?io?i?/ieo aeine?aeaeaiue, a
oaeiae noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy oa ?o aiae?c
aeeiiai? aaoi?ii naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

?acoeueoaoe aeine?aeaeaiiy iia?aeiieai? oa iaaiai?ai? ia can?aeaii?
E?einueeiai iaoeiaiai oiaa?enoaa oa?aiaao?a, VII Oe?a?inueeiio
a?io?i?/iiio c”?cae? (Ee?a,1997 ?.), ia i?aeeaoaae?aeueiiio can?aeaii?
oa?aiaaoe/ieo eaoaae? E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i.N.?.Aai?a??anueeiai.

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 7 iaoeiaeo ?ia?o.

No?oeoo?a oa ianya aeena?oaoe??.

Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, ee?i?/ii?
oa?aeoa?enoeee oai?eo ? iaoiae?a ianoaaeaiiy, aeaae ?c 5-oe ?icae?e?a ca
iaoa??aeaie iniaenoeo aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a aeanieo
aeine?aeaeaiue, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e ? nieneo
e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 141 noi??ioe?, ?ethno?iaaia 10
oaaeeoeyie ? 20 ?enoieaie. Nienie aeei?enoaii? e?oa?aoo?e aeeth/a? 274
aeaea?aea.

CI?NO AeINE?AeAEAIIss.

Ee?i?/ia oa?aeoa?enoeea ianoaaeaieo oai?eo ? iaoiaee aeine?aeaeaiiy.

O aeine?aeaeaiiy aeeth/aii 85 oai?eo ia ?I (68 /ieia?e?a, 17 ae?iie) o
a?oe? a?ae 27 aei 79 ?ie?a. Ae?aaiic ?I iaa?oioiaoaaany ia aea/aii?
ee?i?/ii? ea?oeie caoai?thaaiiy, ci?ie AEA a aeeiai?oe? ? ?acoeueoaoao
aic?iieia?/ieo ? a?io?i?/ieo aeine?aeaeaiue. Eiio?ieueio a?oio neeaee 35
i?aeoe/ii caei?iaeo in?a.

Aeey ioe?iee oyaeeino? ii?ooaiue e?iaiia?ao i?e ?I aeei?enoiaoaaee
eeaneo?eaoe?th T.Killip ( Killip T.,Kimball,1969), o a?aeiia?aeiino? c
yeith 56,5% oai?eo aoee a?aeianai? aei ? eeano, 28,2% – aei 2 eiano,
12,9% iaoe??io?a aei 3 eeano ? 2,4% -aei 4 eeano. Ca?aeii eeaneo?eaoe??
oyaeeino? noaio oai?eo ia ?I (Ieeieaaaa E.O.,A?iiia Ae.I.,1988) 4,7%
oai?eo aoee a?aeianai? aei ? eeano oyaeeino?, 12,9% – aei ??, 40,0% –
aei ??? ? 42,4% iaoe??io?a – aei ?O eeano oyaeeino?. A oe?eiio
ianoaaeai? oai?? aoee ?iciiae?eai? ia ne?aeoth/? ee?i?/i? a?oie: ?a (1-2
eeane oyaeeino? ca eeaneo?eaoe??th AEIOe AII N?N?), ??a (3 eean
oyaeeino?), ???a (4 eean oyaeeino?), ?a (? eean ca eeaneo?eaoe??th
T.Killip), ?Ia (2 eean), ???a (3-4 eeane), ?a (oai?? ia ?I aac coaoey Q
ia AEA (NQMI), ??a (oai?? ?c coaoeai Q ia AEA (QMI), ?ae (oai?? ia ?I
caaeiuei? no?iee e?aiai oeoii/ea),??ae ( oai?? ia ?I ia?aaeiuei? no?iee
e?aiai oeoii/ea), ???ae (oai?? ia oee?eoey?iee ?I).

A 1-o, 7-9-o, 14-21-o aeiao a?ae ?icaeoeo ?I i?iaiaeeee aeine?aeaeaiiy
ne?aeoth/eo a?ee?a ne?iaaoee e?ia?: AIb i?aaeueaoieio (IA), OO,OeI,AI,
aeueoa-1-?I,aeueoa-2-IA, aeueoa-1-EA, IgG,IgA,IgM, N3 ? N4. Iaoa??aeii
aeey aeine?aeaeaiiy neoaeeea ne?iaaoea e?ia?. Aecia/aiiy e?euee?niiai
ai?noo a?ee?a o aeine?aeieo ne?iaaoeao i?iaiaeeee iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? ii Iai/ei? a iiaeeo?eaoe?? E??tho?ia ?.O. (1974 ?.).

Noaoenoe/ia ia?iaea ?acoeueoao?a aeeth/aea a naaa i?ae?aooiie
na?aaeiueiai a?eoiaoe/iiai cia/aiiy eiioeaio?aoe?? eiaeiiai ?c
aeine?aeieo a?ee?a ne?iaaoee e?ia?- I, na?aaeiueiai eaaae?aoe/iiai
a?aeoeeaiiy-. Ioe?iea aeinoia??iino? ?acoeueoao?a ia?aaeaa/aea
aecia/aiiy na?aaeiuei? iiieeee na?aaeiuei? a?eoiaoe/ii? -m,
aeinoia??iino? ??cieoe? na?aaei?o aaee/ei ii t e?eoa??th No”thaeaioa.
Aeey iicia/aiiy neee ? iai?yieo ca”yceo i?ae iieacieeaie eiioeaio?aoe??
aeine?aeieo a?ee?a aecia/aee eiao?oe??io ei?aeyoe?? rxy. On? ?ic?aooiee
i?iaiaeeee ca i?ia?aiith “Statgraph”.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy.

A 1-2-o aeiao a?ae ii/aoeo ?icaeoeo ?I aeinoia??ii cieaeai? ??ai? A?b
(39.32 0.42, p

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