I?I?NOA?NOAI IOI?IIE CAeI?IA”ss OE?A?IE

E?EINUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?I.N.?.AAI?A??ANUeEIAI

IA?ANEIEIAA ?IAA ?AI??AIA

OAeE: 616-005.8 + 616.127.73+ 616.153.96

?IOA?EO I?IEA?AeA ? CI?IE OOIEOe?IIAEUeII CA”ssCAIEO

A?EE?A NE?IAAOEE E?IA?

14.01.11- EA?Ae?IEIA?ss

AAOI?AOA?AO

AeENA?OAOe?? IA CAeIAOOOss IAOEIAIAI NOOIAIss

EAIAeEAeAOA IAAeE*IEO IAOE

N?IOA?IIIEUe, 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.N.?.Aai?a??anueeiai.

Iaoeiaee ea??aiee: aeieoi? iaaee/ie[ iaoe, i?ioani? EOAEOE?I

AIEIAeEIE? OAAeI?IAE*, E?einueeee aea?aeaaiee

iaaee/iee oi?aa?neoao ?i.N.?.Aai?a??anueeiai,
caa?aeo-

th/ee eaoaae?ith aini?oaeueii? oa?ai?? ? 1.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? OAAOeUe

IAOAE?ss ?AAI?AIA, Ee?anueea iaaee/iay
aeaaeai?y

i?neyaeeieiiii? ina?oe ?i. I.E.Ooi?ea,

caa?aeoth/a eaoaae?ith oa?ai??

aeieoi? eaaee/ieo iaoe, i?ioani? EOCIAOeIA

IEEIEA NOAIAIIAE*, E?einueeee aea?aeaaiee

iaaee/iee oi?aa?neoao
?i.N.?.Aai?a??anueeiai,caa?aeo-

th/ee eaoaae?ith aini?oaeueii? oa?ai?? ?
2.

I?ia?aeia i?aai?caoe?y- Oe?a?inueeee IAe? ea?ae?ieia??
?i.I.Ae.No?aaeanea

I?i?noa?noaa ioi?iie caei?ia”y Oe?a?ie,
i.Ee?a

Caoeno a?aeaoaeaoueny ”20” ea?oiy 1999 ?ieo i _14_ aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 52. 600. 01 E?einueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i.N.?.Aaia??anueeiai (333006, i. N?ioa?iiieue,
aoe. Eai?ia 5/7).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N. ?. Aai?a??anueeiai (333006,
i. N?ioa?iiieue, aoe. Eai?ia 5/7).

Aaoi?aoa?ao ?ic?neaii”20” aa?aciy 1999 ?ieo.

O/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani? I. O.
Iaco?aoeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

Aeooaeuei?noue oaie.

Oe?iea iioe?aiiy ?oai?/ii? oai?iae na?oey (?ON) , a oaeiae aeniea
nia?oi?noue a?ae ?ioa?eoo i?iea?aea (?I) in?a i?aoeacaeaoiiai a?eo
noaaeyoue a ?yae aeooaeueieo i?iaeai ?aiith ae?aaiinoeeo, ioe?ieo
ia?aa?ao, oneeaaeiaiue ? iiaeaeueoiai i?iaiico i?e ?I (Iaea?aae/
O.TH.,1997; Aia?ia A.A., 1998). O?oaeiiu? aeeoa?aioe?aeueii?
ae?aaiinoeee ?I o oai?eo c iaoei?/iith ee?i?/iith oa
aeaeo?iea?ae?ia?ao?/iith ea?oeiith caoai?thaaiiy aeoea?coaaee iiooee
a?io?i?/ieo e?eoa???a ooeiaeaeaiiy i?iea?aea, ye? aeicaieythoue
aecia/eoe ??ci? aoaie eiai ?icaeoeo. A inoaii? ?iee iniaeeao oaaao
i?eaa?oathoue iiaeeeaino? iii?oi?oaaiiy a?eeiaiai i?io?eth oai?iai, oae
ye aiii iiaea aooe aeei?enoaii ia o?eueee aeey ae?aaiinoeee, aea ? aeey
aecia/aiiy i?iaiico (Ei?i/eei E.I., I?eiaa I.A.,1990; Aiaaiaeeia
I.TH.,AEo?aaeaaa E.A.,1990).

A?aoiaoth/e iie?ooieoe?iiaeuei?noue a?ee?a, o?nio ooieoe?iiaeueio
caeaaei?noue i?ae ie?aieie a?eeaie, ia i?aenoaa? ?o aea/aiiy iiaeia
ioa?aeoa?ecoaaoe ye noai i?aai?cio a oe?eiio, oae ? oa?aeoa?, nooi?iue
oyaeeino?, i?iaiic eiie?aoiiai caoai?thaaiiy. I?e oeueiio, /ei a?eueoa
e?euee?noue aeine?aeieo a?ee?a,oei a?eueoa eiia??i?noue ciaeoe iaae?ei?
e?eoa??? ioe?iee. Iiaeeea?noue ia??ai? c ae?aaiinoeeith caoai?thaaiiy
neeanoe oyaeaiiy i?i ae?aaeai?noue aeano?oeoeaieo ? ?aia?aoeaieo
i?ioean?a o i?iea?ae? ia? aaeeea i?aeoe/ia cia/aiiy aeey i?iaaaeaiiy
e?eoaaeueieo caoiae?a oa i?aai?caoe?? aeeoa?aioe?eiaaiiai i?aeoiaeo aei
?aaa?e?oaoe?? oai?eo.

Ca”ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa ? /anoeiith ieaiiai? iaoeiai-aeine?aeii? ?iaioe
eaoaae?e aini?oaeueii? oa?ai?? ? 1 E?einueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i.N.?.Aai?a??anueeiai (iiia? aea?aeaaii? ?a?no?aoe?? 0198U
016039).

Iaoa ? caaea/? aeine?aeaeaiiy.

I?iaiae?coaaoe aca?iica”ycee i?ae ee?i?/iei ia?aa?aii, i?iaiicii ?I ?
oa?aeoa?ii ci?ie ie?aieo a?eeiaeo nenoai i?aai?cio ia i?aenoaa? aea/aiiy
a?ee?a ne?iaaoee e?ia? oai?eo ia ?I c iaoith iie?ioaiiy ae?aaiinoeee oa
?aaa?e?oaoe?? ?ioa?eoo i?iea?aea.

Caaea/? aeine?aeaeaiiy:

1. O oai?eo ia ?I ??ciiai iioe?aiiy, aeeaeie oa eieae?caoe?? aea/eoe
??aaiue a?ee?a-?aaeoaio?a aino?i? oace, aioeieneaeaioiiai caoenoo,
o?anii?oieo a?ee?a, ?ioiiaeiaoe?i?a,a?ee?a eiiieaiaioo iniiaieo
?ia?a?oi??a i?ioa?iac.

2. I?iaanoe aiae?c ci?ie ie?aieo a?ee?a, ?o ca”yceo c ee?i?/iei
ia?aa?aii ? i?iaiicii ?ioa?eoo i?iea?aea.

3. Aeae?eeoe e?eoa??? ioe?iee ae?aaeaiino? aeano?oeoeaieo ? ?aia?aoeaieo
i?ioean?a ia i?aenoaa? aea/aiyy aeeiai?ee a?ee?a o ne?iaaooe? e?ia?
oai?eo ia ?ioa?eo i?iea?aea.

4. I?inoaaeeoe aeeiai?eo ci?ie eiioeaio?aoe?? a?ee?a ne?iaaoee e?ia? o
oai?eo ia ?I a caeaaeiino? a?ae i?iaaaeaii? oa?ai??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

I?iaaaeai? aeine?aeaeaiiy aeicaieeee anoaiiaeoe aenieo ae?aaiinoe/io
oe?ii?noue aecia/aiiy ?yaeo aeine?aeieo a?ee?a o ?iciaaeoaaii?
aeeno?io?/ieo ? iae?ioe/ieo i?ioean?a o i?iea?ae?.

Aeyaeaia caeaaei?noue ci?ie ??ai?a oea?oeiieacieio (OeI), o?ainoa?eio
(OO),aaioiaeia?io (AI), aeueoa-1-?ia?a?oi?a i?ioa?iac (aeueoa-1-?I),
aeueoa-2-iae?iaeiaoe?io (aeueoa-2-IA), aeueaoi?io (A), aeueoa-1-eeneiai
ae?eii?ioa?io (aeueoa-1-EA), ?ioiiaeiaoe?io A (IgA), N3 ? N4 eiiiiiaio?a
nenoaie eiiieaiaioo (N3 ? N4) a?ae oyaeeino? ia?aa?ao caoai?thaaiiy.

Aeyaeaii cieaeaiiy eiao?oe??io?a OeI/OO, ? aeueoa-1-?I/ aeueoa-2-IA i?e
iani?eyoeeaiio ia?aa?ao caoai?thaaiiy, ui iiaea neoaeeoe i?iaiinoe/iith
iciaeith ? aeei?enoiaoaaoeny aeey aecia/aiiy e?eoaaeueii? oaeoeee.
Cao?eniaaia ?aeaioe/i?noue ci?ie a?eeiaiai niaeo?o a a?oiao oai?eo,
oyaee?noue ia?aa?ao ?I o yeeo aecia/aeany ??cieie e?eoa??yie.

I?aeoe/ia oe?ii?noue ?iaioe.

Ai?iaaaeaeaiiy a i?aeoeeo aeine?aeaeaiue ii aecia/aiith eiioeaio?aoe??
aeine?aeieo a?ee?a o ne?iaaooe? e?ia? oai?eo iiaea aooe oe?iiei i?e
ae?aaiinoeoe? ?I ? aeeoa?aioe?aeuei?e ae?aaiinoeoe? ??cieo oi?i
?oai?/ii? oai?iae na?oey, a oaeiae aeicaiey? ioe?ieoe ae?aaeai?noue
aeano?oeoeaieo ? ?aia?aoeaieo i?ioean?a a i?aai?ci?, ui aea?
iiaeeea?noue aeeoa?aoe?eiaaii i?aeoiaeeoe aei e?eoaaiiy ? ?aaa?e?oaoe??
oai?eo ia ?I. ?ic?iaeai? e?eoa??? iiaeaeueoiai ia?aa?ao caoai?thaaiiy,
ye? iathoue i?iaiinoe/ia cia/aiiy, oea ni?ey? nai?/aniiio aianaiith
ei?aeoea o ieai e?eoaaiiy oai?iai ia ?I. Ia i?aenoaa? iii?oi?oaaiiy
a?eeiaiai i?io?eth a?oi oai?eo ia ?I i?aeoaa?aeaeaia iaa?oioiaai?noue
ee?i?/ieo e?eoa???a oyaeeino? ?I.

Iniaenoa o/anoue aaoi?a a ?ic?iaoe? iniiaieo iieiaeaiue aeena?oaoe??.

?iaioa aeeiiaia ia eaoaae?ao aini?oaeueii? oa?ai?? ? 1 (caa?aeoth/ee-
aeieoi? iaaee/ieo iaoe, i?ioani? A.O.Eoaeoe?i) ? a?ieia?/ii? o?i??
(caa?aeoth/ee- aeieoi? iaaee/ieo iaoe, i?ioani? ?.O.E??tho?i)
E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.N.?.Aai?a??anueeiai
ia aac? ?ioa?eoiiai a?aeae?eaiiy 6-i? i?nueei? ee?i?/ii? e?ea?i?
i.N?ioa?iiiey, E?einueeiai ?anioae?eainueeiai ea?ae?ieia?/iiai
aeeniaina?o. Iniiaiee ianya ee?i?/ieo, a?io?i?/ieo aeine?aeaeaiue, a
oaeiae noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy oa ?o aiae?c
aeeiiai? aaoi?ii naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

?acoeueoaoe aeine?aeaeaiiy iia?aeiieai? oa iaaiai?ai? ia can?aeaii?
E?einueeiai iaoeiaiai oiaa?enoaa oa?aiaao?a, VII Oe?a?inueeiio
a?io?i?/iiio c”?cae? (Ee?a,1997 ?.), ia i?aeeaoaae?aeueiiio can?aeaii?
oa?aiaaoe/ieo eaoaae? E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i.N.?.Aai?a??anueeiai.

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 7 iaoeiaeo ?ia?o.

No?oeoo?a oa ianya aeena?oaoe??.

Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, ee?i?/ii?
oa?aeoa?enoeee oai?eo ? iaoiae?a ianoaaeaiiy, aeaae ?c 5-oe ?icae?e?a ca
iaoa??aeaie iniaenoeo aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a aeanieo
aeine?aeaeaiue, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e ? nieneo
e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 141 noi??ioe?, ?ethno?iaaia 10
oaaeeoeyie ? 20 ?enoieaie. Nienie aeei?enoaii? e?oa?aoo?e aeeth/a? 274
aeaea?aea.

CI?NO AeINE?AeAEAIIss.

Ee?i?/ia oa?aeoa?enoeea ianoaaeaieo oai?eo ? iaoiaee aeine?aeaeaiiy.

O aeine?aeaeaiiy aeeth/aii 85 oai?eo ia ?I (68 /ieia?e?a, 17 ae?iie) o
a?oe? a?ae 27 aei 79 ?ie?a. Ae?aaiic ?I iaa?oioiaoaaany ia aea/aii?
ee?i?/ii? ea?oeie caoai?thaaiiy, ci?ie AEA a aeeiai?oe? ? ?acoeueoaoao
aic?iieia?/ieo ? a?io?i?/ieo aeine?aeaeaiue. Eiio?ieueio a?oio neeaee 35
i?aeoe/ii caei?iaeo in?a.

Aeey ioe?iee oyaeeino? ii?ooaiue e?iaiia?ao i?e ?I aeei?enoiaoaaee
eeaneo?eaoe?th T.Killip ( Killip T.,Kimball,1969), o a?aeiia?aeiino? c
yeith 56,5% oai?eo aoee a?aeianai? aei ? eeano, 28,2% — aei 2 eiano,
12,9% iaoe??io?a aei 3 eeano ? 2,4% -aei 4 eeano. Ca?aeii eeaneo?eaoe??
oyaeeino? noaio oai?eo ia ?I (Ieeieaaaa E.O.,A?iiia Ae.I.,1988) 4,7%
oai?eo aoee a?aeianai? aei ? eeano oyaeeino?, 12,9% — aei ??, 40,0% —
aei ??? ? 42,4% iaoe??io?a — aei ?O eeano oyaeeino?. A oe?eiio
ianoaaeai? oai?? aoee ?iciiae?eai? ia ne?aeoth/? ee?i?/i? a?oie: ?a (1-2
eeane oyaeeino? ca eeaneo?eaoe??th AEIOe AII N?N?), ??a (3 eean
oyaeeino?), ???a (4 eean oyaeeino?), ?a (? eean ca eeaneo?eaoe??th
T.Killip), ?Ia (2 eean), ???a (3-4 eeane), ?a (oai?? ia ?I aac coaoey Q
ia AEA (NQMI), ??a (oai?? ?c coaoeai Q ia AEA (QMI), ?ae (oai?? ia ?I
caaeiuei? no?iee e?aiai oeoii/ea),??ae ( oai?? ia ?I ia?aaeiuei? no?iee
e?aiai oeoii/ea), ???ae (oai?? ia oee?eoey?iee ?I).

A 1-o, 7-9-o, 14-21-o aeiao a?ae ?icaeoeo ?I i?iaiaeeee aeine?aeaeaiiy
ne?aeoth/eo a?ee?a ne?iaaoee e?ia?: AIb i?aaeueaoieio (IA), OO,OeI,AI,
aeueoa-1-?I,aeueoa-2-IA, aeueoa-1-EA, IgG,IgA,IgM, N3 ? N4. Iaoa??aeii
aeey aeine?aeaeaiiy neoaeeea ne?iaaoea e?ia?. Aecia/aiiy e?euee?niiai
ai?noo a?ee?a o aeine?aeieo ne?iaaoeao i?iaiaeeee iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? ii Iai/ei? a iiaeeo?eaoe?? E??tho?ia ?.O. (1974 ?.).

Noaoenoe/ia ia?iaea ?acoeueoao?a aeeth/aea a naaa i?ae?aooiie
na?aaeiueiai a?eoiaoe/iiai cia/aiiy eiioeaio?aoe?? eiaeiiai ?c
aeine?aeieo a?ee?a ne?iaaoee e?ia?- I, na?aaeiueiai eaaae?aoe/iiai
a?aeoeeaiiy-. Ioe?iea aeinoia??iino? ?acoeueoao?a ia?aaeaa/aea
aecia/aiiy na?aaeiuei? iiieeee na?aaeiuei? a?eoiaoe/ii? -m,
aeinoia??iino? ??cieoe? na?aaei?o aaee/ei ii t e?eoa??th No”thaeaioa.
Aeey iicia/aiiy neee ? iai?yieo ca”yceo i?ae iieacieeaie eiioeaio?aoe??
aeine?aeieo a?ee?a aecia/aee eiao?oe??io ei?aeyoe?? rxy. On? ?ic?aooiee
i?iaiaeeee ca i?ia?aiith “Statgraph”.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy.

A 1-2-o aeiao a?ae ii/aoeo ?icaeoeo ?I aeinoia??ii cieaeai? ??ai? A?b
(39.32 0.42, p<0.001), OO (2.850.07,p<0.001),IgM (0.920.02, p<0.01), IgA (1.530.05,p<0.05), niinoa??aa?oueny oaiaeaioe?y aei iaae?iiy ai?noo aeueoa-1-?I ? IgG. A oie aea /an aeinoia??ii ae??n ??aaiue aeueoa-2-IA (2.560.09, p<0.001), aeueoa-1-EA (1.030.02,p <0.001), OeI ? AI (a?aeiia?aeii 0.520.01 ? 1.960.04,?<0.01), a?aei?/aia oaiaeaioe?y aei i?aeaeuaiiy ai?noo N3 ? IA. Ia 7-9-o aeiao a?ae ii/aoeo ?icaeoeo ?I i?iaeiaaeothoue cieaeoaaoeny ??ai? AIb ? IgA, eiioeaio?aoe?y IgG caeeoa?oueny ia iiia?aaeiueiio ??ai?, niinoa??aa?oueny oaiaeaioe?y c?inoaiiy eiioeaio?aoe?? OO ? IgM. I?iaeiaaeo?oueny ??no eiioeaio?aoe?? OeI (0.560.01,?<0.01), AI (2.150.5, ?<0.001), C3 (0.970.03,p<0.001), aeueoa-1-EA (1.070.03, ?<0.001), o?ioe cieaeo?oueny, aea caeeoa?oueny ua aenieei ??aaiue aeueoa-2-IA, aeniei aeinoia??ii c?inea eiioeaio?aoe?y IA (0.490.01,?<0.01), niinoa??aa?oueny iaaeinoia??ia i?aeaeuaiiy ai?noo aeueoa-1-?I (3.02 0.01). 14-21-a aeiaa a?ae ?icaeoeo ?I a?aei?/aia oaiaeaioe??th aei ii?iae?caoe?? an?o iieaciee?a, caeeoa?oueny iecueeei eeoa ??aaiue IgA (1.470.02, p<0.01), iacia/ii i?aeaeuaiee ai?no aeueoa-2-IA, AI, cieaeaiee ??aaiue OO. I?ioyaii onueiai ia??iaeo niinoa?aaeaiiy a?aei?/ai? iacia/i? eieeaaiiy o ai?noo N4. I?e aea/aii? iieaciee?a ??aiy a?ee?a ne?iaaoee e?ia? a a?oiao oai?eo ia ?I ??cii? oyaeeino? (oaaeeoey) caa?oa? ia nauea oaaao a?eueo ae?aaeaia i?aeaeuaiiy eiioeaio?aoe?? OeI a a?oiao oai?eo c eaaeei ia?aa?aii caoai?thaaiiy (a?.1a ? 1a) a 1-2-o aeiao a?ae ii/aoeo ?icaeoeo ?I, yeee aei 7-9-? aeiae ? aeinoia??iei (p<0.001). O a?oiao 2a, a, 3a, a i?e eiioeaio?aoe?? OeI oaeiae a?aei?/aiee ia 7-9-o aeiao a?ae ii/aoeo caoai?thaaiiy. O an?o aeine?aeieo a?oiao ??aaiue OeI ii?iae?co?oueny ia 2-3 oeaei? a?ae ?icaeoeo ?I. Aiae?coth/e aeeiai?eo OeI, iaiao?aeii a?aei?oeoe, ui a oe?eiio, ye a a?oiao oai?eo ia ?I ye? ?iciiae?eai? ia eeane oyaeeino? ca eeaneo?eaoe??th AEIOe AII N?N?, oae ? a i?oiao oai?eo, ye? ?iciiae?eai? ca eeaneo?eaoe??th T.Killip, ??aaiue OeI ia caeaaeaa a?ae iaaeoi aaaeeiai noaio iaoe??io?a, a?aei?/aeany eeoa a?eueo ae?aaeaia oaiaeaioe?y aei i?aeaeuaiiy eiai eiioeaio?aoe?? aaea a 1-2 aeiao o oai?eo c a?eueo eaaeei ia?aa?aii caoai?thaaiiy ( 1a ? 1a a?.). ?icaeoie o oai?eo aino?i? e?aioeoii/eiai? iaaeinoaoi?no? (AEOI) aai ea?ae?iaaiiiai oieo oaeiae nooo?ai ia aieeaaee ia nooi?iue i?aeaeuaiiy ??aiy OeI a?aeiia?aeii iieaciee?a o a?oi?, ui a?aeiia?aea? aeayeei e?oa?aoo?iei aeaiei (Ai?aioeaeca I.E., Ia?aaeaaeca E.E.,1981). Ie aeae?eeee a?oio ?c 5 iaoe??io?a, o yeeo oaea a 1-2 aeiao a?aei?/aeiny cia/ia cieaeaiiy ??aiy OeI (29-45%). ?c ieo 4 iaoe??ioa aoee iioeeiai a?eo, o ieo ca?a?no?iaaiee o?ainio?aeueiee ?I, ia?aa?a caoai?thaaiiy aoa aaaeeei, noi?iaiaeaeoaaany ?icaeoeii oaeeo oneeaaeiaiue, ye iaa?ye eaaai?a, ieioua ii?ooaiiy iiceiaiai e?iaiia?ao ii ?oai?/iiio oeio, iie?oiiia aeno?anenoie?y, ieaioeeaa a?eoi?y, na?oeaaa iaaeinoaoi?noue (NI) 1-2 no. Oa?aeoa?iei ? iayai?noue o?ii?/ii? aeeoaeueii? iaaeinoaoiino? (AeI) o oeeo oai?eo. O an?o aeine?aei?o a?oiao niinoa??aaeiny iaae?iiy eiioeaio?aoe?? OO c i?i?iaeueieie iieacieeaie a 1-2 aeiao a?ae ii/aoeo ?icaeoeo ?I (oaaeeeoey), i?e/iio a?eueo ae?aaeaia cieaeaiiy ??aiy OO a?aei?/aeiny a 1a a?., a a a?oiao 3a, a oea cieaeaiiy aoei i?i?iaeueiei. Aei 7-9 aeiae caoai?thaaiiy niinoa??aaeany oaiaeaioe?y aei ?inoo iieaciee?a ? ia 2-3 oeaei? ??aaiue OO iaaeeaeaany aei cia/aiue o eiio?ieuei?e a?oi?. A a?oiao 3a, a ??no eiioeaio?aoe?? OO o?ioe a?aeno?i/aii a /an? ? aei 14- 21 aeiae iieacieee OO aoee ieae/a cia/aiue a ?ioeo aeine?aeieo a?oiao. sse aeey aeine?aeieo a?oi, oae ? aeey ie?aieo oai?eo iaie aoa ?ic?aoiaaiee eiao?oe??io OeI/OO, yeee ia aeoieo aeayeeo aaoi??a (Anaoeeay E.I., Aai?ia Ae.TH.,1990), oa?aeoa?eco? caaaeueio aioeieenio aeoeai?noue (AIA) ne?iaaoee e?ia?. Iaea?eueo iecueeee eiao?oe??io cao?eniaaiee o 3 a a?oi?. A ie?aieo oai?eo a?eueo iecuee? eiao?oe??ioe ( <0.12) a?aei?/ai? i?e o?ainio?aeueiiio iioe?aiiio ?I. Ii??aithth/e aeeiai?eo ee?i?/ii? ea?oeie caoai?thaaiiy o oai?eo c aenieei ? iecueeei ni?aa?aeiioaiiyi OeI/OO ne?ae a?aei?oeoe ??cieoeth a ia?aa?ao caoai?thaaiiy i?e ia?a?niii iiae?aieo noaiao oai?eo. A?ia?i?iaeoeoe?y a?eueieo ?aaeeeae?a a ii?aeiaii? ?c cieaeaiiyi oaeaeeino? ae?i?iaoe?? (Burton K.P.,1988) i?eaiaeeoue aei ca?eueoaiiy eiioeaio?aoe?? noia?ieneaeieo ? a?ae?ieneeueieo ?ii?a, ye? aeeeeeathoue ia?ieneaeaoe?th e?i?ae?a ee?oeiii? iaia?aie, aeeeeeath/e aeiaeaoeiaa o?aaeaiiy i?iea?aea. Ia aeoieo ?yaeo aeine?aeiee?a, iaeiith ?c eaiie i?ioeano aeoeaaoe?? IIE i?e ?oai?? i?iea?aea ? ca?eueoaiiy ?icoiaeo aioeieneaeaio?a ? cieaeaiiy iiooaeiino? oa?iaioieo ? iaoa?iaioieo aioeieneaeaioieo nenoai ?oai?ciaaieo oeaiei (Ai?aioeaeca I.A.,1981; Aeeaiei I.A., 1989). A ca”yceo c oeei iiaea aooe iaa?oioiaaiei canoinoaaiiy aioeieneaeaio?a a oa?ai?? aino?iai ?I o oai?eo c NI, o?ii?/iith AeI o aeiaaeeo, yeui a 1-2 aeiao ia? i?noea oaiaeaioe?y aei cieaeaiiy ??aiy OeI aai i?e iecueeiio eiao?oe??io? OeI/OO. I?i oea na?ae/aoue ?acoeueoaoe canoinoaaiiy o?eiaoaceae?ia a 1-o aeiao o 14 oai?eo ia ?I, a ne?iaaooe? 4-o ?c yeeo niinoa??aaeiny cieaeaiiy ??aiy OeI (<0.32 a/e) ? eiao?oe??ioa OeI/OO (<0.09), ca iaoeie aeaieie aoei iani?eyoeeaith i?iaiinoe/iith iciaeith. A aino??oiio ia??iae? o oeeo iaoe??io?a ?icaeioeeny caa?iceea? aeey aeeooy oneeaaeiaiiy (AEOI, anenoie?y). Iaeiae, iio?i niinoa??aaeany iiceoeaia aeeiai?ea, noai noaa?e?coaaany, o 3-o ?c ieo aino?ee ia??iae ?I i?io?eaa aac oneeaaeiaiue. Ia?aa?a ?I a ?ioeo 10 iaoe??io?a oa?aeoa?ecoaaany ??ciiiai?oi?noth ee?i?/ii? ea?oeie, a aino?iio ia??iae? ?I o ieo niinoa??aaeeny ??ci? oneeaaeiaiiy (AEOI, ?aoeeaeeae ?I), 1 oai?a aia?ea aiane?aeie ?ic?eao i?iea?aea. A 1-2 aeiao o oai?eo ia ?I ??cii? eieae?caoe?? ia aeyaeai? cia/i? a?aei?iiino? a iieacieeao OeI, iaeiae, a?eueo ??cea cieaeaiiy OO cao?eniaaii i?e ?I caaeiuei? no?iee e?aiai oeoii/ea, a iaioa anueiai cieaeaiei ??aaiue OO aeyaeany o oai?eo ia oee?eoey?iee ?I. A?aei?/a?oueny a?eueo aeniea eiioeaio?aoe?y OO i?e QMI, i?ae i?e NQMI. Eiao?oe??io OeI/OO a a?oi? oai?eo ia NQMI neeaa 0.2, a a?oi? oai?eo ia QMI- 0.17, ui a?aeia?aaea? a?eueo iecueeo AIA ne?iaaoee e?ia? oai?eo ia QMI, ui iiaea aooe i?aenoaaith aeey i?ecia/aiiy aioeieneaeaioii? oa?ai?? a a?eueo ?aii? no?iee ?icaeoeo QMI. O aeine?aeieo a?oiao iieacieee eiioeaio?aoe?? aeueoa-2-IA ? aeueoa-1-?I ?iciiae?eeeeny ne?aeoth/ei /eiii. A 1-2 aeiao a a?oiao 3a,a a?aei?/aeiny iaae?iiy ??aiy aeueoa-1-?I, yea noaaaei ana a?eueo ae?aaeaiei aei 7-9 aeiy caoai?thaaiiy, a oie /an, ye a ?ioeo a?oiao niinoa??aaany ??no iieaciee?a c iaeneioiii aei 7-9 aeiae. Ia 2-3 oeaei? ??aaiue aeueoa-1-?I iaaeeceany aei cia/aiue o eiio?ieuei?e a?oi?. Ai?no aeueoa-2-IA a 1-2 aeiao aoa i?aeaeuaiei o oai?eo on?o a?oi, i?e/iio iaeneiaeueieie cia/aiiy aoee a a?oiao 3a, a. Oea i?aeaeuaiiy eiioeaio?aoe?? aaea a1-2 aeiao a?ae ii/aoeo ?icaeoeo ?I iiynith?oueny o/anoth aeueoa-2-IA a yeino? iaeiiai ?c iniiaieo ?ia?a?oi??a eae?e?a?i?a ieacie (Eaueineee E.A.,Noaeiaaa E.E.,1989) a iaeo?ae?caoe?? oeaieiieo ? ieaciaieo i?ioaac, ui ni?ey? aaeueioaaiith e?i?iiaaiaco. ?acii c N1-aeoeaaoi?ii oa ?ioeie eiiiiiaioaie aioei?ioaacii? aeoeaiino? a?i neeaaea? ia?oee aoaeii aaeaioeaieo ?aaeoe?e, ye? iai?aaeai? ia noaa?e?caoe?th aaiiaeeiai?ee. Aei 14-21 aeiy caoai?thaaiiy ??aaiue iinooiiai cieaeoaaany aei cia/aiue ii?ie, oiae? ye o a?oiao aeoaea aaaeeeo oai?eo o oeae ia??iae eiioeaio?aoe?y aeueoa-2-IA caeeoaeany i?aeaeuaiith. O a?eueoino? oai?eo o a?oiao 3a, a aeeiai?ea ci?ie aeueoa-1-?I a?aeiia?aeaea aeeiai?oe? a 2a, a a?oiao, iaeiae, o aeayeeo iaoe??io?a niinoa??aaeiny nooo?aa (aei 38%) cieaeaiiy aeueoa-1-?I. Ia?aa?a ?I o oeeo oai?eo aoa iniaeeai iani?eyoeeaei. O an?o iaoe??io?a, o yeeo ?I i?ea?a aei eaoaeueiiai iane?aeeo, niinoa??aaany aeao?oeeo aeueoa-1-?I, ui yaey?oueny iani?eyoeeaith i?iaiinoe/iith iciaeith. I?e oeueiio a a?oi? caa??aaeany caaaeueia oaiaeaioe?y aei i?aeaeuaiiy ??aiy aeueoa-1-?I ia 7-9 aeiao caoai?thaaiiy. sseui i?eeiyoe ??aaiue aeueoa-1-?I o oai?eo ia iaoneeaaeiaiee ?I ca “aaeaioaoe?eio ii?io”, oi o aeiaaeeao eiai aeao?oeeoo iiaeia aiai?eoe i?i iaaeinoaoith aeoeai?noue aioei?ioaaciiai iioaioe?aeo o oai?eo ?c iani?eyoeeaei ia?aa?aii caoai?thaaiiy. I?e/eiith cieaeaiiy eiioeaio?aoe?? aeueoa-1-?I a ne?iaaooe? e?ia? iiaea aooe eiai ?ioaineaia niiaeeaaiiy i?e iaeo?ae?caoe?? i?ioa?iac, ye? neoaeaoue aeoeaaoi?aie e?i?iiaaiaco ( I?eia A.I.,Nieiae I.I.,1990). Oaeiae iaiiaeeeai aeeeth/eoe iiaeeea?noue eiai ia?aeiiiai aeao?oeeoo. Iaie aoa ?ic?aoiaaiee eiao?oe??io aeueoa-1-?I/aeueoa-2-IA o oai?eo ia ?I a 1-2 aeiao a?ae ii/aoeo ?icaeoeo ?I. O eiio?ieuei?e a?oi? cia/aiiy eiao?oe??ioo -1.47. O a?oi? oai?eo ia ?I oeae eiao?oe??io neeaa- 1-.05. Ii aeine?aeiei a?oiai cia/aiiy eiao?oe??ioo ?iciiae?eeeeny ne?aeoth/ei /eiii: 1a- 1.07; 1a -1.02; 2a -1.07; 2a -1.10; 3a -0.96; 3a -0.95. Oaeei /eiii, /?oei i?inoaaeo?oueny oaiaeaioe?y aei cieaeaiiy oeueiai iieacieea i?e iineeaii? oyaeeino? ?I.Oeae aea aeniiaie i?aeoaa?aeaeo?oueny aea/aiiyi aeaiiai eiao?oe??ioo a ie?aieo oai?eo. ?c 6 iaoe??io?a c iieacieeii ni?aa?aeiioaiiy aeueoa-1-?I/aeueoa-2-IA <0.75 o o?ueio ?I i?ea?a aei eaoaeueiiai iane?aeeo, a 1 oai?a aia?ea /a?ac 3 i?nyoey aiane?aeie ?icaeoeo iiaoi?iiai (3-ai) ?I, o aeaio aeiaaeeao ?I noi?iaiaeaeoaaany ?icaeoeii AEOI. ?icaeoie aeao?oeeoo aeueoa-1-?I iiaea na?ae/eoe i?i eiai nooo?ao ?ieue o ae?oaiio aoaeii? eiiiainaoi?ieo ?aaeoe?e, eiee iioaioe?aeuei? iiaeeeaino? aeueoa-2-IA oa ?ioeo e?i?iac ae/a?iai?. ?icaeoie aoi?eiiiai aeao?oeeoo aeueoa-1-?I na?ae/eoue i?i iayai?noue “aaa??eii?” neooaoe?? a aaeaioeaieo ?aaeoe?yo i?aai?cio ? ? i?iaiinoe/ii iani?eyoeeaith iciaeith. Oaeei /eiii, o oai?eo c iecueeeie iieacieeaie eiioeaio?aoe?? aeueoa-1-?I ? eiao?oe??ioo aeueoa-1-?I/aeueoa-2-IA iiaea aooe iieacaia cai?nia oa?ai?y eae?e?a?i-i?ioaacieie ?ia?a?oi?aie. O a?oiao ianoaaeaieo oai?eo ia ?I a?aei?/aany ??no eiioeaio?aoe?? AI, ii/eiath/e c 1-2 aeiae, aeinyaath/e iaeneioio aei 7-9 aeiy caaoi?thaaiiy, iio?i cieaeoth/enue aei 3-4 oeaeiy, aea ia aeinyaath/e cia/aiue ii?ie. I?e/iio, /ei iaoe?i?oa aoei o?aaeaiiy i?iea?aea (3 a a?oia), oei aeua cia/aiiy AI, oea iiynith?oueny aeeeaeii aaeeei? e?eueeino? AA?, iaae?aoi??a, i?ioaac, a oiio /ene? e?ciniiaeueieo o?ieiaeo i?ioaac, eaoainei?a A,I,?, ?ia?a?oi?ii yeeo ? AI (Aeaeoei A.A., Iiaeeiaa E.E.,1988). ia?inoaiiyi e?eueeino? i?iaeoeo?a ooeiaeaeaiiy, o aeaaaeaii? yeeo oaeiae i?eeia? o/anoue AI. Caa?oa? ia naaa oaaao cia/ia i?aeaeuaiiy eiioeaio?aoe?? AI a ii??aiyii? c 1a ? 2a a?oiaie a 3a a?oi? oai?eo ia ?I, aea a?eueo ae?aaeai? ii?ooaiiy aiiainoaco. Oeae oaeo a?aei?/aiee ? ?ioeie aaoi?aie (*a?ieoianeay E.N..Oaaei?ia A.A.,1985), a aeine?aeaeaiiyo yeeo niinoa??aaany a?eueo aenieee ??aaiue AI o oai?eo c oneeaaeiaiiyie a aino?iio ia??iae? ?I, ye? a?aeiia?aeaee oa?aeoa?enoeoe? oai?eo 3a a?. a iaoeo aeine?aeaeaiiyo. I?e/iio, i?e caaaeuei?e oaiaeaioe?? aei ii?iae?caoe?? ??aiy AI a a?oi? aei 3-4 oeaeiy caoai?thaaiiy, a ne?iaaooe? e?ia? oai?eo, o yeeo o oe? no?iee ?icaeioeeny oneeaaeiaiiy ( iaa?ye eaaai?a, ?aoeeaeea ?I), ??aaiue AI caeeoaany aenieei, ia?aaeuoth/e ii?io ia 30%. Aiae?c ai?noo AI iieacaa iaio ae?aaeaia i?aeaeuaiiy ??aiy AI o oai?eo ia NQMI (1.920.8, p<0.05), ui iiaea na?ae/eoe i?i a?eueo aeoeaia niiaeeaaiiy oeueiai a?eea a ?acoeueoao? ?aia?ooc?iiiiai ooeiaeaeaiiy i?iea?aea, yeee ia? i?noea i?e NQMI, yeee oa?aeoa?eco?oueny iaeiie/aiiyi a oeaiei? ?yaeo iaoaaie?o?a (noia?ieneaeieo ai?ii?a, ia?aeen?a, a?ae?ieneeueieo ?aaeeeae?a oa ?i.). Oaeei /eiii, aeine?aeaeaiiy ??aiy AI ne?iaaoee e?ia? o oai?eo ia ?I a 1-2 -o aeiao a?ae?a?a? iaaio ?ieue o ?iciaaeoaaii? aeeno?io?/ieo ? iae?ioe/ieo i?ioean?a o na?oeaaiio i”yc?, yeui a?aooaaoe aeai? i?i a?aenooi?noue ci?ie ??aiy AI i?e noaiiea?ae?? oa aiaieuaa?e aeeno?io?? i?iea?aea (I?eiaa A.A.,Caaai?iaeiee N.A.,1982). Aeine?aeaeaiiy eiioeaio?aoe?? oeueiai a?eea a aeeiai?oe? ia? aaaeeeaa i?iaiinoe/ia cia/aiiy. ??aaiue aeueoa-1-?I a aeine?aeieo a?oiao oai?eo ia ?I ?iciiae?eeany ne?aeoth/ei /eiii: a 1-2 aeiao iaeneiaeueia cia/aiiy eiioeaio?aoe?? aeueoa-1-EA a?aei?/aii a 3 a a?oi?, yea aei 7-9 aeiy caoai?thaaiiy ia ci?ithaaeiny. A ?ioeo a?oiao c ia?oi? aeiae a?aei?/aany iinooiiaee ??no ??aiy aeueoa-1-EA c iaeneioiii ia 7-9 aeaiue ? iinooiiaei cieaeaiiyi aei 2-3 oeaeiy. Ii??aiyiiy ee?i?/ieo a?oi oai?eo ia ?I aeyaeei a?eueo aeniea cia/aiiy aeueoa-1-EA o oai?eo c aaaeeei ia?aa?aii caoai?thaaiiy. Oae, i?aeaeuaiiy eiioeaio?aoe?? aeueoa-1-EA aoei aeinoia??iei a 3 a a?oi? iaa?oue a 1-2 aeiao. Ni?aa?aeiioaiiy ??aiy aeueoa-1-EA o oai?eo c ??ciei ee?i?/iei ia?aa?aii ?I aeyaeei a?eueo aenie? iieacieee, ye? aeinyaathoue o ?yae? aeiaaee?a noaoenoe/ii aeinoia??iiai cia/aiiy o oai?eo c oaeeie oneeaaeiaiiyie , ye ?aoeeaeea ?I., AEOI.Cieaeaiiy eiioeaio?aoe?? aeueoa-1-EA a 1-2 aeiao ? cia/ii a?eueo iecuee? iieacieee oeueiai a?eea a ii??aiyii? c na?aaei?ie iieacieeaie a ee?i?/i?e a?oi? ia 7-9 aeiao noi?iaiaeaeoaaeiny oi?ioaaiiyi o oai?eo aino?i? ? o?ii?/ii? aiaa?ecie na?oey, i?e/iio 3 oai?eo aia?ee a?ae ?ic?eao i?iea?aea. Iiaeeeai, ooo i?inoaaeo?oueny aca?iic”ycie iaaeinoaoiino? ?aia?aoeaieo i?ioean?a ?c cieaeaiiyi aieeao aeueoa-1-EA ye aeoeaaoi?a ?inoo o?a?iaeano?a ? cae?aiino? eiai ca”ycoaaoe eieaaai. O an?o aeine?aeieo a?oiao niinoa??aa?oueny cieaeaiiy eiioeaio?aoe?? A?b aaea a 1-o aeiao , yea aeinyaa? iaeneiaeueieo cia/aiue ia 7-9 aeiao, a aei 3-4 oeaeiy caoai?thaaiiy i?inoaaeoaaeany oaiaeaioe?y aei ii?iae?caoe?? iieacieea. I?e/iio, c iiaaae/aiiyi i?ioeano cieaeaiiy ??aiy AIb a?eueoa ae?aaeaii (oaaeeoey). Oae, a 3a ? 3a a?oiao oaea a 1-o aeiao a?aei?/aii aeinoia??ia cieaeaiiy eiioeaio?aoe?? A?b. Aiae?c ??aiy A?b a ie?aieo oai?eo iieacaa a?eueo ae?aaeaia cieaeaiiy eiioeaio?aoe?? a 1-2 aeiao oa oiia?eueiaio aeeiai?eo ii?iae?caoe?? o iaoe??io?a ?c oneeaaeiaiei ia?aa?aii ?I .Oaeiae a 1-2 aeiao niinoa??aaeiny aeinoia??ia cieaeaiiy ??aiy A?b a ne?iaaooe? e?ia? oai?eo ia QMI (38.98 0.51,p<0.001), a oie /an ye cieaeaiiy eiioeaio?aoe?? A?b a a?oi? oai?eo ia NQMI aoei iaio cia/iei. O aeiaaeeao ?icaeoeo oee?eoeyoi?iiai ?I a 1-2 aeiao aoa a?aei?/aiee iaea?eueo iecueeee ??aaiue A?b, eieae?caoe?y aea ?I ia aieeaaea ia iieaciee eiioeaio?aoe?? A?b. Ca aeaieie e?oa?aoo?e, i?e ?I cieaeo?oueny e?euee?noue A?b , yeee ia? o?ainii?oio cae?ai?noue aei 52% (Iaeueiee E.A., Aa?aiianeee I.A.,1985),i?e/iio oea cieaeaiiy a?eueo ae?aaeaii ia 2 oeaei? caoai?thaaiiy, eiee ca iaoeie aeaieie, a?aei?/a?oueny iaeieae/a caaaeueia eiioeaio?aoe?y A?b. Ia oii? cieaeaiiy caaaeueii? e?eueeino? A?b, aeao?oeeo o?ainii?oiiai A?b noa? ua a?eueo ae?aaeaiei.Ianoa/a o?ainii?oii? ooieoe?? ne?iaaoeiaiai A?b i?iyaey?oueny oei, ui ii?iaeueii ia?aiini? oeei a?eeii ?a/iaeie, iniaeeai e?i?aee,a?aeeeaaeathoueny a no?ieao noaeei aai aaciina?aaeiuei a oeaieiao, ia?aoeiaeaeath/e oei naiei ii?iaeueiiio iaoaaie?cio ia ??ai? oeaiei ? ee?oei (Ioaeye A.A.,Na?aaethe I.C.,1990), ui iiaea iineeeoe oyaee?noue ia?aa?ao caoai?thaaiiy. Iaie ia aeyaeai? a?aei?iiino? a iieacieeao IA a caeaaeiino? a?ae oyaeeino? ?I (oaaeeoey), o?eueee a a?oi? 1a i?ioyaii onueiai ia??iaeo aeine?aeaeaiiy ??aaiue IA i?aeoe/ii ia a?ae??ci?any a?ae cia/aiue ii?ie. A a?oi? oai?eo ia NQMI a 1-2 aeiao caoai?thaaiiy a?aei?/aeany a?eueo aeniea eiioeaio?aoe?y IA. ??aaiue IA ia caeaaeaa a?ae eieae?caoe?? ?I. Iiaeeeai, a?eueo oe?iiei oea aeine?aeaeaiiy ? i?e i?iaaaeaii? eiai a ia?? c aecia/aiiyi N-?aaeoeaiiai a?eea (N?A), oae ye ca aeaieie aeayeeo aaoi??a (Harrison S.B.,1987), iaea?eueo /ooeeaei iieacieeii aino?ioaciai? a?aeiia?ae? i?e ?I ? a?aeiioaiiy N?A aei IA. ?I , ye aeoeaiee ?ioiiee oa aooi?ioiiee i?ioean oa?aeoa?eco?oueny ii?ooaiiyie ?ioiieia?/ieo iieaciee?a (Neaaecaaneay E.E.,1997). ?acoeueoaoe aeine?aeaeaiiy ??ai?a aea/aieo iaie ?ioiiaeiaoe?i?a o oai?eo c ??ciei ee?i?/iei ia?aa?aii caoai?thaaiiy ?iciie?eyeeny ne?aeoth/ei /eiii (oaaeeoey). O oai?eo 1a a?oie i?ioyaii onueiai ia??iaeo niinoa??aaeiny aeinoia??ia cieaeaiiy eiioeaio?aoe?? IgA c i?i?iaeueiei ??aiai ia 7-9 aeiao a?ae ?icaeoeo ?I, iaaeinoia??ia cieaeaiiy ??aiy IgM. O oai?eo 1a a?oie a 1-2 aeiao a?aei?/aii cieaeaiiy eiioeaio?aoe?? IgA, yea i?ia?anoaaei, i?e/iio i?e cieaeaiiy a?aei?/aany ia 14-21 aeiao a?ae ii/aoeo caoai?thaaiiy (p<0.01),a ia?oo aeiao ?I niinoa??aaeiny aeinoia??ia cieaeaiiy IgM c iine?aeoth/ith oaiaeaioe??th aei ii?iae?caoe??. A a?oiao oai?eo 2a ? 2a oaeiae iaei i?noea cieaeaiiy eiioeaio?aoe?? IgA i?ioyaii onueiai ia??iaeo niinoa?aaeaiiy, i?e/iio a a?oi? 2a i?i?iaeueia cia/aiiy ??aiy IgA a?aei?/aii ia 7-9 aeiao, a a a?oi? 2a iieacieee a 1-2 ? 7-9 aeiao aeniei aeinoia??ii a?ae??ciyeeny a?ae iieaciee?a o eiio?ieuei?e a?oi?, i?i?iaeueiee iieaciee cao?eniaaiee a 1-2 aeiao a?ae ii/aoeo ?icaeoeo ?I. O oeeo a?oiao a 1-2 aeiao aeinoia??ii cieaeoaaeany eiioeaio?aoe?y IgM c ianooiiith ii?iae?caoe??th. Aiaeia?/i? ci?ie ??aiy ?ioiiaeiaoe?i?a a?aeaoaaeeny ? a a?oiao 3a ? 3a: i?ioyaii onueiai ia??iaeo niinoa?aaeaiiy cieaeoaaeany eiioeaio?aoe?y IgA c i?i?iaeueiei cia/aiiyi ia 7-9 aeiao a?ae ii/aoeo caoai?thaaiiy, caeeoath/enue aeinoia??ii cieaeaiith ? ia 3-4 oeaei?. Niinoa??aaeiny oaeiae iaae?iiy ??aiy IgM a 1-2 aeiao ? iiaeaeueoa ca?eueoaiiy eiioeaio?aoe?? aei 14-21 aeiae. Eieeaaiiy ??aiy IgG o an?o a?oiao caeeoaeeny iacia/ieie i?ioyaii onueiai ia??iaeo niinoa?aaeaiiy. Ia aeyaeaii ??cieoeue o iieacieeao ??ai?a IgA ? IgM i?e QMI ? NQMI, a?aei?/aii a?eueo iecueeee ??aaiue IgG i?e QMI. Aiae?c ci?ie eiioeaio?aoe?? ?ioiiaeiaoe?i?a i?e ?I ??cii? eieae?caoe?? aeyaea a?eueo iecueea cia/aiiy IgG i?e oee?eoeyoi?iiio ?I, IgA ? IgM - i?e ?I caaeiuei? no?iee e?aiai oeoii/ea. A?aoiaoth/e iaeaaei?noue oee?eoethth/eo aioeo?e aei i”yciaeo aieieii i?iea?aea aei ?ioiiaeiaoe?i?a eeano I, iaae?iiy ??aiy IgM ? IgA iiaeia iiynieoe ?o aeoeaiei aoyaiaiiyi a neeaae ?ioiieo eiiieaen?a, ye? caoiieththoueny ee?oeiaie nenoaie iae?ioaa?a, a oaeiae o?eno?oueny a noaeeiao. I?e/iio, iao? aeai? i?i a?eueo ae?aaeaia iaae?iiy eiioeaio?aoe?? IgM a 1-2 aeiao ?I ocaiaeaeothoueny c aeaieie i?i oa, ui aioeo?ea aei i”yciaeo aieieii eeano IgM c”yaeythoueny ia 2-4 aeiao caoai?thaaiiy (Neiaeiuenee N., Iio/uinee I.,1987). Caneoaiaothoue oaaao iaea?aeai? iaie aeai? i?i ci?ie eiioeaio?aoe?? N3 ? N4 a ne?iaaooe? e?ia? oai?eo ia ?I. I/aaeaeii, i?e ?I ia? i?noea aeoeaaoe?y nenoaie eiiieaiaioo, yea ? ?iaeeeaoi?ii ia aeeth/aiiy ?oai?ciaaiiai i?aaio a e?iaioie (Oaaaei A.E., ?iaeeiiia A.ss.,1994), i?ci?oa iiaea noaoe aeiiaoi?ii a?ieia?/ii aeoeaieo ?a/iaei, ye? cae?ai? iineethaaoe oyaee?noue ?iceaae?a aiiainoaco. Oea i?aeoaa?aeaeo?oueny a?eueo aeieeaaeiei aiae?cii aeeiai?ee N3 ? N4 o oai?eo c ??ciei ee?i?/iei ia?aa?aii caoai?thaaiiy (oaaeeoey). A 1a ? 1a a?oiao a?aei?/aeiny i?aeaeuaiiy ??aiy N3 c ia?oi? aeiae ?icaeoeo ?I c iaeneioiii ia 7-9 aeiao ? ii?iae?caoe??th iieaciee?a aei 3-4 oeaeiy. Niinoa??aaeeny iaaeinoia??i? ci?ie ??aiy N4 i?ioyaii onueiai ia??iaeo. A a?oiao 2a ? 2a aeinoia??ia i?aeaeuaiiy ??aiy N3 a?aei?/aeiny oaeiae aei 7-9 aeiy, ci?ie N4 aoee iacia/ieie. Iaea?eueo? ci?ie aeine?aeieo a?ee?a niinoa??aaeeny o oai?eo 3a ? 3a a?oie. A oeeo a?oiao a ia?oee aeaiue ?I aeyaeaii aeinoia??ia ciaioaiiy eiioeaio?aoe?? N3 ? N4 ?c i?aeaeuaiiyi N3 ia 7-9 aeaiue caoai?thaaiiy. A 1-2 aeiao a?ae ii/aoeo ?icaeoeo ?I a?aei?/aeiny iaaeinoia??ia i?aeaeuaiiy eiioeaio?aoe?? N3 ? N4 a a?oi? oai?eo ia NQMI. Aeyaeaii aeinoia??ia i?aeaeuaiiy eiioeaio?aoe?? N4 (0.31 0.02, ?<0.01), a a?oi? oai?eo ia ?I caaeiuei? no?iee e?aiai oeoii/ea. Iaea?aeai? aeai? iiaeooue na?ae/eoe i?i i?aeneeaia niiaeeaaiiy N3 ? N4 a oiiaao aeoeaii? ?iaioe nenoaie eiiieaiaioo o oai?eo ia aino?ee ?I c iani?eyoeeaei ia?aa?aii i?ioeano a ia?o? aiaeeie a?ae ii/aoeo caoai?thaaiiy. Ine?eueee a?eee nenoaie eiiieaiaioo i?e ?o aeoeaaoe?? iiaeooue neoaeeoe aeaea?aeii iaae?aoi??a iaeo?io?eueii? ?io?eueo?aoe??, ye? cae?ai? i?eaanoe aei ?icoe?aiiy ciie ?ioa?eoa, a oaeiae noaeeiii-aeoeaieo ?a/iaei, iiaeia i?eionoeoe, ui “iaaeaeoeaaoe?y” nenoaie eiiieaiaioo o oai?eo ia ?I a ia?o? aiaeeie a?ae ii/aoeo caoai?thaaiiy neoaeeoue iaeiith ?c aaaeeeaeo eaiie ?icaeaath/iainy iaoieia?/iiai i?ioeano ? iiaea i?eaanoe aei iineeaiiy oyaeeino? noaio oai?eo. Oaeei /eiii, cieaeaiiy ??aiy N3 ? N4 a ia?o? aiaeeie a?ae ii/aoeo ?icaeoeo ?I iiaea neoaeeoe iani?eyoeeaith i?iaiinoe/iith iciaeith. Ie i?inoaaeeee ci?ie a?eeiaiai niaeo?o a caeaaeiino? a?ae oiai, /e canoiniaoaaeany o iaoe??ioa o?iiaie?oe/ia oa?ai?y. Aiae?c ??aiy aeayeeo ?c aeine?aeieo a?ee?a o aeaio a?oiao oai?eo ia ?I, a iaei?e ?c yeeo oai?? iaea?aeoaaee oa?ai?th no?aioie?iacith aai oeae?acith o na?aaeiueioa?aiaaoe/ieo aeicao, a ae?oa?e -iaoe??ioai ia i?ecia/aeeny o?iiaie?oe/i? i?aia?aoe, ia aeyaea aeinoia??ieo a?aei?iiinoae o ??ai? aeine?aeieo a?ee?a i?ae a?oiaie. I/aaeaeii, oea iia”ycaii c oei, ui ia?oee caa?? e?ia? aeey aeine?aeaeaiue i?iaiaeeany o iaoe??io?a aaciina?aaeiuei i?e iaaeoiaeaeaii?, ua aei i?ecia/aiiy e?eoaaiiy, a ianooiiee - o?eueee ia 7-9 aeiao. AENIIAEE. 1. I?e ?ioa?eo? i?iea?aea a 1-2 aeiao a?ae ii/aoeo ?icaeoeo caoai?thaaiiy niinoa??aa?oueny aeinoia??ia cieaeaiiy ??aiy aeueaoi?io, o?anoa?eio, ?ioiiaeiaoe?i?a A ? I, aeinoia??ia i?aeaeuaiiy eiioeaio?aoe?? oea?oeiieacieio, aaioiaeia?io, aeueoa-2-iae?iaeiaoe?io, aeueoa-1-eeneiai ae?eii?ioa?io. ??aaiue oeacaieo a?ee?a, ca aeeeth/aiiyi ?ioiiaeiaoe?io A, ii?iae?co?oueny ia 3-4 oeaei? a?ae ?icaeoeo ?ioa?eoo i?iea?aea i?e ni?eyoeeaiio ia?aa?ao caoai?thaaiiy. 2. Niinoa??aa?oueny caeaaei?noue ci?ie eiioeaio?aoe?? oea?oeiieacieio, o?ainoa?eio, aaioiaeia?io, aeueoa-1- ?ia?a?oi?a i?ioa?iac, aeueoa-2-iae?iaeiaoe?io, aeueaoi?io, i?aaeueaoi?io, aeueoa-1- eeneiai ae?eii?ioa?io, ?ioiiaeiaoe?io A, N3 ? N4 eiiiiiaio?a nenoaie eiiieaiaioo a?ae oyaeeino? ia?aa?ao caoai?thaaiiy. 3. Eiao?oe??ioe oea?oeiieaciei /o?ainoa?ei ? aeueoa-1-?ia?a?oi? i?ioa?iac / aeueoa-2-iae?iaeiaoe?i cieaeothoueny i?e iani?eyoeeaiio ia?aa?ao caoai?thaaiiy oa ?o aecia/aiiy a 1-2 aeiao a?ae ii/aoeo ?icaeoeo ?ioa?eoo i?iea?aea iiaea aooe aeei?enoaii aeey i?iaiico oa ei?aeoe?? e?eoaaiiy c aeei?enoaiiyi i?aia?ao?a-?ia?a?oi??a i?ioa?iac oa aioeieneaeaio?a. 4. ?ioa?eo i?iea?aea c coaoeai Q oa?aeoa?eco?oueny ae?aaeaiei cieaeaiiyi ??aiy aeueaoi?io, cia/ii aenieeie iieacieeaie eiioeaio?aoe?? aaioiaeia?io, aeueoa-2- iae?iaeiaoe?io, aeueoa-1- eeneiai ae?eii?ioa?io. I?e ?ioa?eo? i?iea?aea aac coaoey Q cia/ii cieaeo?oueny ??aaiue o?ainoa?eio,oa?aeoa?iee a?eueo aenieee ai?no oea?oeiieacieio. 5. Eieae?caoe?y ?ioa?eoo i?iea?aea aeinoia??ii ia aieeaa? ia ai?no aeine?aeieo a?ee?a o ne?iaaooe? e?ia?, iaeiae, aeey oee?eoeyoi?iiai ?ioa?eoo i?iea?aea oa?aeoa?i? i?i?iaeueia eiioeaio?aoe?y aeueaoi?io, aeueoa-1-?ia?a?oi?a i?ioa?iac, iaio ae?aaeaia cieaeaiiy ??aiy o?ainoa?eio, ?ioiiaeiaoe?i?a A ? I. 6. O aeaio a?oiao oai?eo, ?iciiae?eaieo ii oyaeeino? ia?aa?ao ?ioa?eoo i?iea?aea, yea aecia/aeany ??cieie e?eoa??yie, cao?eniaai? ?aeaioe/i? ci?ie a?eeiaiai i?io?eth oai?eo, ui i?aeoaa?aeaeo? iaa?oioiaai?noue ee?i?/ieo e?eoa???a oyaeeino? ?ioa?eoo i?iea?aea. 7. Canoinoaaiiy o?iiaie?oe/ii? oa?ai?? ia aieeaa? ia ai?no o ne?iaaooe? e?ia? oai?eo ia ?ioa?eo i?iea?aea aeueaoi?io, i?aaeueaoi?io, oea?oeiieacieio, o?ainoa?eio, aeueoa-1-?ia?a?oi?a i?ioa?iac, aeueoa-2-iae?iaeiaoe?io i?ioyaii ia?oeo 7-9 ae?a a?ae ii/aoeo ?icaeoeo caoai?thaaiiy. 8. Aecia/aiiy ai?noo aeueaoi?io, oea?oeiieacieio, aaioiaeia?io, aeueoa-1-?ia?a?oi?a i?ioa?iac, aeueoa-2-iae?iaeiaoe?io, aeueoa-1-eeneiai ae?eii?oa?io, ?ioiiaeiaoe?i?a A ? I , N3 ? N4 eiiiiiaio?a nenoaie e?iieaiaioo a ne?iaaooe? e?ia? o oai?eo ia ?ioa?eo i?iea?aea iiaea aooe aeniei ?ioi?iaoeaiei o ae?aaiinoe/iiio ieai?, a oaeiae i?e aecia/aii? i?iaiico ? oaeoeee aaaeaiiy oai?iai. I?AEOE*I? ?AEIIAIAeAOe??. 1. Aecia/aiiy ai?noo aeueaoi?io, o?ainoa?eio, oea?oeiieacieio, aaioiaeia?io, iniiaieo ?ia?a?oi??a i?ioa?iac, aeueoa-1-eeneiai ae?eii?ioa?io, ?ioiiaeiaoe?i?a A ? I, N3 ? N4 eiiiiiaio?a nenoaie eiiieaiaioo iiaea aooe aeei?enoaii a yeino? aeiaeaoeiaiai iaoiaeo aeey oni?oii? ae?aaiinoeee ?ioa?eoo i?iea?aea ? aeeoa?aioe?aeueii? ae?aaiinoeee ??cieo oi?i ?oai?/ii? oai?iae na?oey. 2. I?e iaoneeaaeiaiiio caaithaaii? ?ioa?eoo i?iea?aea niinoa??aa?oueny ne?aeoth/a aeeiai?ea a?ee?a ne?iaaoee e?ia?: ??no ??aiy OeI c iaeneioiii ia 7-9 aeiao, cieaeaiiy eiioeaio?aoe?? OO, yea iaea?eueoa ae?aaeaia a 1-2 aeiao caoai?thaaiiy, i?aeaeuaiiy eiioeaio?aoe?? iniiaieo ?ia?a?oi??a i?ioa?iac c ia?oi? aeiae ?icaeoeo ?I, i?e/iio a oe? ae no?iee a?aei?/a?oueny iaeneiaeueiee ??aaiue aeueoa-2-IA, ??no eiioeaio?aoe?? AI c iaeneioiii ia 7-9 aeiao, iaeneiaeueia i?aeaeuaiiy ??aiy aeueoa-1-EA a?aeaoaa?oueny ia 2 oeaei? caoai?thaaiiy, cieaeaiiy eiioeaio?aoe?? AIb a?eueo ae?aaeaia ia 7-9 aeiao ?I, a 1-2 aeiao cieaeo?oueny ??aaiue IgA, IgM, ci?ie eiiiiiaio?a nenoaie eiiieaiaioo, ye? oa?aeoa?ecothoueny aeayeei i?aeaeuaiiyi eiioeaio?aoe?? N3 a 1-2 aeiao c iaeneioiii ia 7-9 aeiao. Niinoa??aa?oueny oaiaeaioe?y aei ii?iae?caoe?? an?o iieaciee?a ia 3-4 oeaei? caoai?thaaiiy. 3. Cieaeaiiy ??aiy OeI a 1-2 aeiao (aei 45%) , nooo?aa (aei30-40%) cieaeaiiy eiioeaio?aoe?? aeueoa-1-?I a 1-2 aeiao, oiia?eueiaia aeeiai?ea AI, yea oa?aeoa?eco?oueny i?aeaeuaiith (aei 30% aeua ii?ie) eiioeaio?aoe??th a?eea ia 3-4 oeaei? caoai?thaaiiy, a oaeiae cieaeaiiy a 1-2 aeiao iieaciee?a N3 ? N4; na?ae/aoue i?i aeaneio?ii?caoe?th ?iaioe aaaeeeaeo nenoai i?aai?cio, ui iio?aao? aianaiiy ei?aeoea o oaeoeeo aaaeaiiy oaeeo oai?eo. 4. Cieaeaiiy iieaciee?a ni?aa?aeiioaiiy eiioeaio?aoe?? oea?oeiieacieio aei o?ainoa?eio iaioa 0.12 ? aeueoa-1-?ia?a?oi?a i?ioa?iac aei aeueoa-2-iae?iaeiaoe?io iaioa 0.75 a 1-2 aeiao a?ae ii/aoeo ?icaeoeo caoai?thaaiiy ? i?iaiinoe/ii iani?eyoeeaiai iciaeith, yea na?ae/eoue i?i iaiao?aei?noue i??i?eoaoiiai i?ecia/aiiy oaeei oai?ei i?aia?ao?a ?ia?a?oi??a i?ioa?iac oa aioeieneaeaio?a. 5. ?aeaioe/i?noue ci?ie a?eeiaiai niaeo?o ne?iaaoee e?ia? oai?eo ia ?ioa?eo i?iea?aea a aeeiai?oe? i?e ia?ao?aniiio ?iciiae?e? iaoe??io?a ia a?oie ca ??cieie iciaeaie na?ae/aoue i?i iaa?oioiaai?noue canoinoaaiiy a i?aeoeoe? ee?i?/ieo e?eoa???a oyaeeino? ?ioa?eoo i?iea?aea. 6. ?ioa?i?aoaoe?y ?acoeueoao?a aeine?aeaeaiiy ai?noo a?ee?a o ne?iaaooe? e?ia? oai?eo iiaeiia i?iaiaeeoeny c iaeii/aniei aiae?cii ee?i?/ii? ea?oeie caoai?thaaiiy, aeaieo aeaeo?iea?ae?ia?ao?/ieo oa ?ioeo iaoiae?a aeine?aeaeaiiy. NIENIE Ae?OEIAAIEO ?IA?O. 1. Eoauoeei A.O., Ee?thoei E.O., Ia?aneieiaa E.E. Aeeiaieea eciaiaiee aaeeia nuai?ioee e?iae o aieueiuo eioa?eoii ieiea?aea // I?iaeaiu , aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey: O?. E?ui. iaae. ei-oa ei.N.E.Aai?aeaaneiai.-Neioa?iiieue, 1997.-O.133, /. II.-N.3-10. 2. Ia?aneieiaa E.E. O?iaaiue eiaeeaeaeoaeueiuo aaeeia nuai?ioee e?iae eae iieacaoaeue oyaeanoe oa/aiey eioa?aeoa ieiea?aea // Ecaanoey E?uineie Aeaaeaiee Iaoe.-1998.-? 6.-N.15-16. 3. Ia?aneieiaa E.E. Eeeie/aneay oeaiiinoue eco/aiey eiaeeaeaeoaeueiuo aaeeia nuai?ioee e?iae i?e eioa?eoa ieiea?aea //I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiiio?aiaiey : O?. E?ui. iaae. ei-oa ei. N.E.Aai?aeaaneiai. -Neioa?iiieue, 1996.-O.132,/.I.-N.271-273. 4. Ia?aneieiaa ?.?. Aea/aiiy iieaciee?a ?ioiii? nenoaie oa nenoaie eiiieaiaioo o oai?eo ia ?ioa?eo i?iea?aea a aeeiai?oe? // Aeooaeuei? i?iae. ee?i?/. ?ioiieia?? oa aea?aieia?? .- Euea?a, 1997.- ? 2.- N. 139- 143. 5. Naaeiaie A.E., Ia?aneieiaa E.E. Nacyue eaeannia oyaeanoe eioa?eoa ieiea?aea n iaeioi?uie aaeeiauie nenoaiaie ieaciu e?iae // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey : O?. E?ui. iaae. ei-oa ei. N. E. Aai?aeaaneiai.- Neioa?iiieue, 1996.- O. 132, /. I.-C. 274- 278. 6. Ionoeaay ?.A., Ia?aneieiaa E.E., Oacae O. Ei??aeyoeey aaeeia nuai?ioee e?iae o iiai?iaeaeaiiuo e ac?ineuo a ii?ia e i?e iaoieiaee // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-.aeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey : O?. E?ui. iaae. ei-oa ei. N. E. Aai?aeaaneiai.- Neioa?iiieue, 1996.-O. 132, /. I.- N. 265- 267. 7. Eoaeoe?i A.O. , E??tho?i ?.O., Ia?aneieiaa ?.?. Aea/aiiy eiiieaeno ?iaeea?aeoaeueieo a?ee?a ne?iaaoee e?ia? i?e ?ioa?eo? ieiea?aea // VII Oe?a?inueeee a?io?i?/iee c”?cae : Oace aeiiia?ae?.- Ee?a, 1997.-N .36- 37. AIIOAOe?ss. Ia?aneieiaa ?.?. ?ioa?eo i?iea?aea ? ci?ie ooieoe?iiaeueii ca”ycaieo a?ee?a ne?iaaoee e?ia?. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14. 01. 11 -ea?ae?ieia?y. -E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. N. ?. Aai?a??anueeiai, N?ioa?iiieue, 1999. Aeena?oaoe?y i?enay/aia ieoaiiyi ae?aaiinoeee, ioe?iee oyaeeino?, i?iaiico ? iiaeeeaino? ei?aeoe?? e?eoaaiiy oai?eo ia ?ioa?eo i?iea?aea. A ?iaio? i?iaiaeeoueny aiae?c ci?ie aeayeeo a?eeiaeo nenoai i?aai?cio oa ?o ca”yceo c ee?i?/iei ia?aa?aii ? i?iaiicii ?ioa?eoo i?iea?aea, ia i?aenoaa? /iai ?ic?iaeaiee ?yae e?eoa???a ioe?iee ae?aaeaiino? aeano?ooeaieo ? ?aia?aoeaieo i?ioean?a ,ui aeicaieeei aeae?eeoe aeeoa?aioe?eiaai? i?aeoiaee aei ?o ei?aeoe?? ?c canoinoaaiiyi i?aia?ao?a-?ia?a?oi??a i?ioa?iac oa aioeieneaeaio?a. Iieacaia iaa?oioiaai?noue canoinoaaiiy ia i?aeoeoe? ee?i?/ieo e?eoa???a oyaeeino? ?ioa?eoa i?iea?aea. Eeth/ia? neiaa: ?ioa?eo i?iea?aea, ?oai?/ia oai?iaa na?oey, a?eee “aino?i? oace”, aioeieneaeaioe, ?ia?a?oi?e i?ioa?iac. AIIIOAOeEss. Ia?aneieiaa E.E. Eioa?eo ieiea?aea e eciaiaiea ooieoeeiiaeueii naycaiiuo aaeeia nuai?ioee e?iae. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14. 01. 11 - ea?aeeieiaey.- E?uineee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. N. E. Aai?aeaaneiai, Neioa?iiieue, 1999. Aeenna?oaoeey iinayuaia aii?inai aeeaaiinoeee, ioeaiee oa/aiey, i?iaiica e aiciiaeiinoe ei??aeoeee ea/aiey eioa?eoa ieiea?aea. A ?aaioa i?iaiaeeony aiaeec eciaiaiey iaeioi?uo aaeeiauo nenoai i?aaiecia e eo nayce n eeeie/aneei oa/aieai e i?iaiicii eioa?eoa ieiea?aea. A enneaaeiaaiea aeeth/aii 85 aieueiuo EI, eioi?ua auee ?acaeaeaiu ia eeeie/aneea a?oiiu a caaeneiinoe io oyaeanoe oa/aiey, eieaeecaoeee, aeoaeiu e ?ani?ino?aiaiiinoe EI, a oaeaea i?eiaiyaiie oa?aiee. A 1-a, 7-9- a, 14- 21-a nooee io ?acaeoey EI iaoiaeii ?aaeeaeueiie eiioiiaeeooocee i?iaiaeeee enneaaeiaaiey neaaeothueo aaeeia nuai?ioee e?iae: aeueaoieia (A1b), i?aaeueaoieia (IA), o?ainoa?eia (OO), oea?oeiieacieia (OeI), aaioiaeiaeia (AI), aeueoa-1- eiaeaeoi?a i?ioaeiac (aeueoa-1-EI), aeueoa-2- iae?iaeiaoeeia (aeueoa-2-IA), aeueoa-1-eeneiai aeeeii?ioaeia (aeueoa-1-EA), eiioiiaeiaoeeiia (IgG, IgA, IgM), N3 e N4 eiiiiiaioia nenoaiu eiiieaiaia (N3 e N4). Iaoa?eaeii enneaaeiaaiey neoaeeea nuai?ioea e?iae. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee onoaiiaeaii, /oi a 1-2 nooee io ia/aea ?acaeoey EI iaaethaeaaony aeinoiaa?iia nieaeaiea o?iaiy A1b, OO, eiioiiaeiaoeeiia A e I, aeinoiaa?iia iiauoaiea eiioeaio?aoeee OeI, AI, aeueoa-2-IA, aeueoa-1-EA. O?iaaiue oeacaiiuo aaeeia, ca eneeth/aieai IgA, ii?iaeecoaony ia 3-4 iaaeaea io ?acaeoey EI i?e aeaaii?eyoiii oa/aiee caaieaaaiey. Iaia?oaeaia caaeneiinoue eciaiaiey eiioeaio?aoeee OeI, OO, AI, aeueoa-1-EI, aeueoa-2-IA,AIb, aeueoa-1-EA, IgA, N3 e N4 eiiiiiaioia nenoaiu eiiieaiaioa io oyaeanoe oa/aiey caaieaaaiey. Auyaeaii nieaeaiea eiyooeoeeaioia OeI/OO e aeueoa-1-EI /aeueoa-2-IA i?e iaaeaaii?eyoiii oa/aiee EI, /oi iiaeao auoue eniieueciaaii aeey i?iaiica e ei??aeoeee ea/aiey n eniieueciaaieai i?aia?aoia-eiaeaeoi?ia i?ioaeiac e aioeieneaeaioia. I?e EI n coaoeii Q iaaethaeaeinue au?aaeaiiia nieaeaiea o?iaiy A1b, aieaa aunieea iieacaoaee eiioeaio?aoeee AI, aeueoa-2-IA, aeueoa-1-EA. I?e eioa?eoa ieiea?aea aac coaoea Q cia/eoaueiae nieaeaaony o?iaaiue OO, oa?aeoa?ii aieaa aunieia niaea?aeaiea OeI. Eieaeecaoeey EI aeinoiaa?ii ia aeeyao ia niaea?aeaiea eco/aiiuo aaeeia a nuai?ioea e?iae, iaeiaei aeey oee?eoey?iiai EI oa?aeoa?iu ieieiaeueiay eiioeaio?aoeey A1b, aeueoa-1-EI, iaiaa au?aaeaiiia nieaeaiea o?iaiy OO, eiioiiaeiaoeeiia A e I. A aeaoo a?oiiao aieueiuo, ?acaeaeaiiuo ii oyaeanoe eioa?eoa ieiea?aea, ii?aaeaeyaiie ?acee/iuie e?eoa?eyie, caoeene?iaaiu eaeaioe/iua eciaiaiey aaeeiaiai i?ioeey aieueiuo, /oi iiaeoaa?aeaeaao iainiiaaiiinoue eeeie/aneeo e?eoa?eaa oyaeanoe eioa?eoa ieiea?aea. Aiaeec ?acoeueoaoia eco/aiey o?iaiy aaeeia a caaeneiinoe io i?iaiaeeiie oa?aiee iieacae, /oi i?eiaiaiea o?iiaieeoe/aneeo i?aia?aoia ia aeeyao ia niaea?aeaiea a nuai?ioea e?iae aieueiuo EI AIb,IA, OeI, OO, aeueoa-1-EI, aeueoa-2-IA a oa/aiea ia?auo 7-9 nooie io ia/aea ?acaeoey caaieaaaiey. Oaeei ia?acii, ii?aaeaeaiea niaea?aeaiey aeueaoieia, oea?oeiieacieia, o?ainoa??eia, aaioiaeiaeia, aueoa-1- eiaeaeoi?a i?ioaeiac, aeueoa-2-iae?iaeiaoeeia, aeueoa-1-eeneiai aeeeii?ioaeia, eiioiiaeiaoeeiia A e I , N3 e N4 eiiiiiaioia nenoaiu eiiieaiaioa a nuai?ioea e?iae o aieueiuo eioa?eoii ieiea?aea iiaeao auoue aunieieioi?iaoeaiui a aeeaaiinoe/aneii ieaia, a oaeaea i?e ii?aaeaeaiee i?iaiica e oaeoeee aaaeaiey aieueiiai. SUMMARY Pereskokova I.I. Myocardial infarction and change of functionally fixed serum proteins.- Manuscript. The thesis for a Candidate’s degree in medical sciences (speciality 14.01.11 - cardiology). - The Crimea medical university by S.I.Georgievsky, Simferopol, 1999. The thesis is devoted to the questions of diagnostics, estimation of flow, prognosis and possibility of treatment correction of patients with myocardial infarction. In the work is taking analysis of change of some protein systems of organism and their connection with clinical flow and prognosis of myocardial infarction , on these grounds it was developed number of estimation criterions of destructive and reparative processes expressiveness, it was allowed to distinguish differentiate approaches to their correction with use of preparations - proteinase inhibitors and antioxidants. It was showed validity of use in practice of clinical criterions of myocardial infarction severity. Key words: myocardial infarction, myocardial ischemia, “acute phase” proteins, antioxidants, proteinase inhibitors.

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