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I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.aeaae. I.I.Aiaiiieueoey

Aiaoei Ieaia Iao??aia

OAeE
618.2:616.15-097+616.155.194.17-053.31:618.33]-07-08-084:57.083.5:577.1

?ioiia?io?i?/i? aniaeoe ae?aaiinoeee, e?eoaaiiy, i?io?eaeoeee
?acon-eiioe?eoii? aaa?oiino? oa aaiie?oe/ii? oai?iae ieiaea oa
iiaiia?iaeaeaiiai.

14.01.01- Aeooa?noai oa a?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i. Aeaae.
I.I. Aiaiiieueoey IIC Oe?a?ie

Iaoeiaee eiinoeueoaio –

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? A?oaiiiia Aieiaeeie? Na?a?eiae/,

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. Aeaae. I.I.Aiaiiieueoey,
caa?aeoth/ee eaoaae?ith aeooa?noaa oa a?iaeieia?? ? 2;

/eai-ei?aniiiaeaio IAI ? AII Oe?a?ie, aeieoi? iaaee/iee iaoe, i?ioani?,
caneoaeaiee ae?y/ iaoee Oe?a?ie, Noaiaie?anueea Aaeeia Einoyioei?aia,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.I.I.Aiaiiieueoey, i?ioani?
eaoaae?e aeooa?noaa oa a?iaeieia?? ? 1;

aeieoi? iaaee/iee iaoe, i?ioani? Aeaoeaae/ Aaeaioeia ?aaeieei?aia,
Iaoeiai-aeine?aeiee ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII,
caa?aeoth/a a?aeae?eo aaa?oieo c aeno?aaai?oaeueiith iaoaeia??th;

aeaaeai?e AII Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? Aooaiei Aaiaae?e
Ieoaeeiaei, ?inoeooo aa?iioieia?? AII Oe?a?ie, caa?aeoth/ee a?aeae?eo
?ioiieia??.I?ia?aeia onoaiiaa-Ee?anueea iaaee/ia aeaaeai?y
i?neyaeeieiiii? ina?oe?i. I.E.Ooi?ea IIC Oe?a?ie, i.Ee?a, eaoaae?a
aeooa?noaa, a?iaeieia?? oa ia?eiaoieia??

Caoeno a?aeaoaeaoueny 20 n?/iy 2000 ?. i 14 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.03 i?e Iaoe?iiaeueiiio
iaaee/iiio oi?aa?neoao? ?i. Aeaae. I.I.Aiaiiieueoey (04004, i.Ee?a,
aoeueaa? O.Oaa/aiea, 17)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. Aeaae. I.I.Aiaiiieueoey IIC Oe?a?ie (04057,
i.Ee?a, aoe. Ciieia?/ia, 3)

Aaoi?aoa?ao ?ic?neaii 18 a?oaeiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i., aeioeaio
A?oianueeee ss.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. I?iaeaia ?ci?ioiii? aaa?oiino? caa??aa? naith
aeooaeuei?noue ia nueiaiaei? ye aeey oai?aoe/iiai, oae ? i?aeoe/iiai
aeooa?noaa o ca’yceo c /anoioith aeaii? iaoieia??, iniaeeainoyie
ia?aa?ao aaa?oiino? ? ?iae?a, aenieeie a?aenioeaie ia?eiaoaeueieo
caoai?thaaiino? e nia?oiino? a?ae aaiie?oe/ii? oai?iae ieiaea ?
iiaiia?iaeaeaiiai (I.E.A?yaa e niaao., 1992; J.W.Dudenhausen, 1992;
M.J.Whittle, 1992; O.A?ean, 1993).

Aeinyaioo? inoaii?i /anii oni?oe o aea/aii? aeaii? i?iaeaie aeicaieeee
cia/ii ?icoe?eoe oyaeaiiy noiniaii ?ioiieia?/ieo a?aeiioaiue iaoa?? e
ieiaea, aeeaoa c?icoi?oe ie?ai? noi?iie iaoiaaiaco ?ioiieia?/iiai
eiioe?eoo, iicia/eoe iia? oeyoe i?io?eaeoeee oa e?eoaaiiy
(A.W.Robertson, 1992; B.Thilaganatan et al, 1992; A.N.A?oaiiiia e
niaao., 1993; I.A.Oea/aiei e niaao., 1996).

Aeei?enoaiiy no/anieo iaoiae?a ioe?iee noaio ieiaea, a oaeiae
i?iaaaeaiiy niaoeeo?/ii? i?io?eaeoeee ?ioiiaeiaoe?iii Rh(D) aeicaieeei
cieceoe ia?eiaoaeueio nia?oi?noue a?ae aaiie?oe/ii? oai?iae. Iaeiae
noaa?e?caoe?y ?? /anoioe, ui a?aecia/a?oueny ca inoaii? ?iee, oi?ie ??
oneeaaeiaiue aeey iiaeaeueoiai ?icaeoeo aeeoeie iaiieaaeeai aeiaaathoue
ae??oaiiy ua ia ?ica’ycaiieo ieoaiue.

Iacaaeia?euei? ?acoeueoaoe e?eoaaiiy ?ci?ioiiiai eiioe?eoo oa eiai
iane?aee?a o iiaiia?iaeaeaieo iaoiiaeai? iaaeinoaoi?i aea/aiiyi ie?aieo
eaiie iaoiaaiaco, a?aenooi?noth ?aii?o e?eoa???a ?icaeoeo aaiie?oe/ii?
oai?iae, i?iaiinoe/ieo oano?a aecia/aiiy nooiaiy oyaeeino? o?aaeaiiy
ieiaea. Ia aei e?ioey c’yniaaia ?ieue ci?i a ?ioiiiio noaoon? iaoa??.

Aeine?aeaeaiiy aieiaiiai eiiieaeno a?noinoi?niino? ethaeeie (HLA)
aeicaieeei anoaiiaeoe HLA-aaiaoe/i? ia?ea?e noeeueiino? aai no?eeino?
aei oeo /e ?ioeo caoai?thaaiue (A.I.Oaaaeei, E.Ae.Na?iaa, 1991;
TH.I.Iaoiia e niaao., 1994). Iaeiae, iaoai?cie ?aae?caoe?? iiaeeeai?
niaaeeiai? noeeueiino?, ui eiio?ieththoueny aaiaie HLA i?e
?acon-nainea?e?caoe??, caeeoathoueny ua iaaeinoaoiuei aea/aieie.

A iniia? aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai eaaeeoue
aaiie?c a?eo?ioeeo?a i?ae aieeaii ?acon-aioeo?e iaoa?? (K.N.Nicolaides,
C.H.Rodeck, 1992; A.I.Aeecee oa ni?aaao., 1996). ?ieue ee?oeiieo iaia?ai
o oeueiio i?ioean? aea/aia iaaeinoaoiuei. Iineeaiiy ia?aeeniiai
ieeniaiiy e?i?ae?a (IIE) i?ecaiaeeoue aei ae?acieo ci?i a
aioeieneaeaioi?e nenoai?, ii?ooo? no?oeoo?ii-ooieoe?iiaeueio
i?aai?caoe?th a?ieia?/ieo iaia?ai ? ? oi?aa?naeueiei iaoai?ciii
o?aaeaiiy ee?oeie. O oeueiio aniaeo? ? aeooaeueiei aea/aiiy i?ioean?a
IIE, noaio a?eo?ioeeoa?ii? iaia?aie o aaa?oieo c ?acon-nainea?e?caoe??th
aeey ioe?iee noaio iai?iieo i?ioean?a, aeyaeaiiy ?aii?o iciae ?o ci?i ?
ae??oaiiy ieoaiiy uiaei ei?aeoe?? iaoaaie?/ieo ii?ooaiue.

Oaeei /eiii, ia nueiaiaei? caeeoathoueny iac’yniaaieie iaoai?cie
?aae?caoe?? niaaeeiai? noeeueiino?, ui eiio?ieothoueny aaiaie HLA, ?ieue
?ioiieia?/ii? ?aaeoeaiino? oa iaoaaie?/ieo ci?i i?aai?cio iaoa?? a
iaoiaaiac? aaiie?oe/ii? oai?iae ieiaea. O ca’yceo c oeei aaaeeeaith
caaea/ath ? c’ynoaaiiy cia/ouino? e oa?aeoa?o aca?iica’yceo ??cieo
iaoai?ci?a aiiainoaco i?e ?acon-eiioe?eo?, ae??oaiiy ieoaiiy uiaei
iaiao?aeiino? ?ioiieia?/ii? oa iaoaaie?/ii? ei?aeoe??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia ca?aeii c ieaiii iaoeiai-aeine?aeii? ?iaioe eaoaae?e aeooa?noaa
oa a?iaeieia?? ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aaneoaoo ?i. aeaae.
I.I.Aiaiiieueoey ? ? o?aaiaioaie ?ia?o “?ic?iaeoe ? ai?iaaaeeoe a
i?aeoeeo ioi?iie caei?ia’y aoaeoeai? iaoiaee i?io?eaeoeee, ae?aaiinoeee
? e?eoaaiiy ano?en?? iiaiia?iaeaeaieo i?e ?acon-eiioe?eo?, aanoic? e
neaaeino? ?iaeiai? ae?yeueiino? c iaoith cieaeaiiy ia?eiaoaeueii?
caoai?thaaiino? oa nia?oiino? (IIC Oe?a?ie, ? aea?aeaaii? ?a?no?aoe??
0194 V 020895, 1992-1994 ??.) ? “Aeine?aeaeaiiy iaae?aoi?ieo iaoai?ci?a
?ioiii? a?aeiia?ae? i?e ?acon-eiioe?eo? c iaoith ?ic?iaee aoaeoeaieo
i?aia?ao?a aeey i?io?eaeoeee oa e?eoaaiiy ?acon-eiioe?eoo i?e
aaa?oiino?” (ia caiiaeaiiy AeEIO Oe?a?ie, ? aea?aeaaii? ?a?no?aoe?? 0194
U 020897, 1994-1996 ??.).

Iaoa ?iaioe. Aea/aiiy ?ioiiaaiaoe/ieo oa ?ioiia?io?i?/ieo aniaeo?a
?aae?caoe?? ?acon-eiioe?eoo, c’ynoaaiiy ie?aieo iaoai?ci?a iaoiaaiaco
oeueiai noaio, ?ic?iaea e?eoa???a ae?aaiinoeee, i?iaiico oa
iaoiaaiaoe/ii? oa?ai?? aeey cieaeaiiy ia?eiaoaeueieo caoai?thaaiino? e
nia?oiino? a?ae aaiie?oe/ii? oai?iae.

Caaea/? aeine?aeaeaiiy

1. Aecia/eoe iniaeeaino? ?ioiieia?/iiai noaoono aaa?oieo i?e
?acon-nainea?e?caoe?? ca e?euee?noth ? ooieoe?iiaeueiith aeoeai?noth
?ioiieiiiaoaioieo ee?oei oa ?o noaiiioeyoe?eiei neeaaeii.

2. Aea/eoe /anoioo ? niieo/aiiy oaiioei?a aaiaoe/ieo nenoai e?ia? aeey
aecia/aiiy a?oi ?eceeo a?aeiinii ?icaeoeo aaaeeeo oi?i aaiie?oe/ii?
oai?iae.

3. C’ynoaaoe ?ioaineai?noue ia?aeeniiai ieeniaiiy e?i?ae?a ?
a?eueii?aaeeeaeueieo i?ioean?a o aaa?oieo c ?acon-nainea?e?caoe??th.

4. I?iaiae?coaaoe aca?iica’ycee i?ae ?ioiiaaiaoe/ieie aa??aioaie,
?ioiiei noaoonii ? iaoaaie?/ieie iniaeeainoyie o aaa?oieo i?e
?acon-eiioe?eo?.

5. Aea/eoe ae?th ?acon-aioeaaio ia ?aii? aoaie ?icaeoeo ?ioiieo ?aaeoe?e
? aecia/eoe eeth/ia? iaoai?cie ?o ?aaoeyoe??.

6. Anoaiiaeoe ee?i?ei-?ioiieia?/i? oa ee?i?ei-a?io?i?/i? e?eoa???
ae?aaiinoeee, i?iaiico ?icaeoeo aaaeeeo oi?i aaiie?oe/ii? oai?iae.

7. Iaa?oiooaaoe aeioe?euei?noue ?ioiieia?/ii? oa iaoaaie?/ii? ei?aeoe??
o aaa?oieo c ?acon-nainea?e?caoe??th; aecia/eoeoa i?eioeeie ??
i?iaaaeaiiy, iieacaiiy oa aoaeoeai?noue.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa io?eiaii aeai? noiniaii
iniaeeainoae ?ioiia?io?i?/iiai aiiainoaco i?e ?acon-eiioe?eo? o
aaa?oieo.

Ia iniia? i?iaaaeaiiai eiiieaeniiai ee?i?ei-?ioiieia?/iiai oa
a?io?i?/iiai aeine?aeaeaiiy aia?oa noi?ioeueiaaia eiioeaioe?y ?icaeoeo
oyaeeeo oi?i aaiie?oe/ii? oai?iae c iiceoe?? aca?iicaeaaeiino? oa
aca?iiiaoiiaeaiino? ?ioii-a?io?i?/iiai noaoono iaoa?einueeiai i?aai?cio.

Aia?oa ?ic?iaeaii iia? ia?aiao?e a?ioai?ethi?i?noeaioiiai aiae?co aeey
ioe?iee i?iieneaeaioii-aioeieneaeaioiiai noaio i?aai?cio, ui aeicaiey?
aeaoaeuei?oa aecia/aoe aeeaeio ? ye?noue iaoaaie?/ieo ii?ooaiue i?e
?acon-eiioe?eo?.

Aia?oa ?ic?iaeaia iaoaiaoe/ia iiaeaeue ioe?iee iaaaciaee ?icaeoeo
aaiie?oe/ii? oai?iae ieiaea ca ?iciiae?eii noeoiiino? ia?aiao??a
ia?aeeniiai ieeniaiiy e?i?ae?a.

Aia?oa anoaiiaeaii aaiaoe/i? ia?ea?e niaaeeiai? noeeueiino? oa aaiaoe/i?
oaeoi?e ?icaeoeo ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? ? ?icaeoeo
aaiie?oe/ii? oai?iae ieiaea e iiaiia?iaeaeaiiai.

Aeaii oai?aoe/ia iaa?oiooaaiiy iiaiai iai?yieo eiiieaeniiai e?eoaaiiy
aaa?oieo c ?acon-nainea?e?caoe??th – naeaeoeaii? ?ioiieia?/ii? oa
iaoaaie?/ii? ei?aeoe??, cai?iiaiiaaiee aeeoa?aioe?eiaaiee i?aeo?ae aei
?? i?ecia/aiiy.

I?aeoe/ia cia/aiiy ?iaioe. Ia iniia? ?ioiiaaiaoe/ieo oa?aeoa?enoee
iaa?oioiaaii ? ooi/iaii a?oie ?eceeo aaa?oieo uiaei ?icaeoeo aaaeeeo
oi?i aaiie?oe/ii? oai?iae.

Anoaiiaeaia ?ioi?iaoe?eia cia/ou?noue ?yaeo ?ioiia?io?i?/ieo iieaciee?a
noaoono ?ci?ioiii? aaa?oii?, cai?iiaiiaaii e?eoa??? ae?aaiinoeee ?
i?iaiico oyaeeino? o?aaeaiiy ieiaea.

Aeiaaaeaii, ui aeei?enoaiiy naeaeoeaii? ?ioiii? oa iaoaaie?/ii?
ei?aeoe?? ciaioo? nooi?iue nainea?e?caoe?? iaoa??, ni?ey? iie?ioaiith
noaio ieiaea ? caaacia/o? iie?auaiiy ia?eiaoaeueieo ?acoeueoao?a.

?ic?iaeaii oa ai?iaaaeaeaii a i?aeoeeo e?eoa??? ?aiiueiai ?icaeoeo
aaiie?oe/ii? oai?iae ? aeai?o ?aoe?iiaeueii? iaoiaaiaoe/ii? oa?ai??
?acon-eiioe?eoo, ui cieaeo? e?euee?noue oyaeeeo oi?i aeaii? iaoieia??.

?ic?iaeaia iaoaiaoe/ia iiaeaeue ioe?iee iaaaciaee ?aae?caoe??
?acon-eiioe?eoo c noeoiiino? ia?aiao??a ia?aeeniiai ieeniaiiy e?i?ae?a
aeicaiey? i?aeaeueoe a??ia?aei?noue i?iaiico aaiie?oe/ii? oai?iae ieiaea
? iiaiia?iaeaeaiiai.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi iaa?oioiaai? oaia,
caaaeaiiy oa iaoiaee aeine?aeaeaiiy, i?iaaaeaii ee?i?ei-eaai?aoi?ia
ianoaaeaiiy ae?iie, aiae?c io?eiaieo ?acoeueoao?a, c?iaeaii i?aenoiee,
aeniiaee ? i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe?? oa ?o iioae?eiaai?noue. Iaoa??aee
aeena?oaoe?? i?aaenoaaeaii ia 3-io ananithciiio neiiic?oi? c
i?aeia?iaeiith o/anoth (Ee?a, 1987), 8-io ?a?iiaenueeiio eiia?an?
aianoac?ieia?a (Aa?oaaa, 1990), ia IX, X c’?caeao aeooa??a-a?iaeieia?a
Oe?a?ie (Ee?a, 1991; Iaeana, 1996), IV eiia?an? na?oiai? oaaea?aoe??
oe?a?inueeeo e?ea?nueeeo oiaa?enoa (Oa?e?a, 1992), ia Ieaioiao i?aae?iiy
iaoeiaiai oiaa?enoaa aeooa??a-a?iaeieia?a Oe?a?ie (A?iieoey, 1993;
Iieoaaa, 1994), iaoeiai-i?aeoe/i?e eiioa?aioe?? aeooa??a-a?iaeieia?a
Oe?a?ie “Ooieoe?iiaeuei? iaoiaee ae?aaiinoeee a aeooa?noa? ? a?iaeieia??
(Aeiiaoeuee, 1994), ia i?aeia?iaeiiio neiiic?oi? “?ioiieia?y
?ai?iaeoeoe??” (Ee?a, 1996).

Ii oai? aeena?oaoe?? iioae?eiaaii 44 iaoeia? i?aoe?. A oiio /ene? 25
iaoeiaeo noaoae o oaoiaeo aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie, oa 3 a
?ioeo aeaeaiiyo. Ii?yae c oeei, o iaoa??aeao iaoeiaeo eiioa?aioe?e,
c’?cae?a – 26.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 250 noi?.
iaoeiiieno. Neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, 6 ?icae?e?a,
caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e. Aiia ?ethno?iaaia 40
oaaeeoeyie oa 8 ?enoieaie. Nienie e?oa?aoo?ieo aeaea?ae iae?/o? 354
?iaioe, a oiio /ene? 234 a?o/eciyieo oa 120 ?iicaiieo aaoi??a.

INIIAIEE CI?NO ?IAIOE

IAOA??AEE OA IAOIAeE AeINE?AeAEAIIss

Aeey ?ica’ycaiiy iinoaaeaieo caaea/ ianoaaeaii 289 iiaoi?iiaaa?oieo
ae?iie o a?oe? a?ae 18 aei 37 ?ie?a a aeeiai?oe? aaa?oiino?: 44 –
?acon-iiceoeai? ae?iee (I a?oia); 70 – ?acon-iaaaoeai? ae?iee aac iciae
?acon-nainea?e?caoe?? (II a?oia); 94 – ?acon-nainea?e?ciaai? ae?iee, ye?
ia?iaeeee ae?oae aac aaiie?oe/ii? oai?iae (III a?oia); 81 –
?acon-nainea?e?ciaaia ae?iea, aaa?oi?noue o eio?eo caaa?oeeanue
ia?iaeaeaiiyi ae?oae c aaiie?oe/ith oai?iaith (IV a?oia). A
ii??yaiyeueiiio aniaeo? i?iaiae?ciaaii iieacieee, ui aea/aeeny, o 20
caei?iaeo iaaaa?oieo ae?iie. O eiaei?e a?oi? oaeiae aoei ianoaaeaii ?
iiaiia?iaeaeaieo.

Aenia?eiaioaeuei? aeine?aeaeaiiy aeeiiaii ia ieoao e?i?? BALB/c.

Ianoaaeaiiy aaa?oieo aoei eiiieaeniei ? aeeth/aei ee?i?/i?, eaai?aoi?i?
oa ?ino?oiaioaeuei? iaoiae? aeine?aeaeaiiy. An?i ianoaaeaiei
i?iaiaeeeenue caaaeueiii?eeiyo? eaai?aoi?i? aeine?aeaeaiiy: caaaeueiee
aiae?c e?ia?, na/?, aecia/aeanue a?oiiaa oa Rh-iaeaaei?noue, aiae?c
aeae?eaiue ia oei?o, eiaaoeia?aia oa ?i. Noai ieiaea ioe?ithaaee ca
?acoeueoaoaie ea?ae?ioieia?ao?? (EOA), oeueo?acaoeiaiai aeine?aeaeaiiy
(OCAe), a?io?ce/iiai i?io?eth ieiaea, ?acoeueoaoaie aii?i- ?
ei?aeioeaioaco.

?ioiiee noaoon aaa?oieo aea/aee oeyoii eiiieaeniiai aeine?aeaeaiiy
iiioeyoe?eiiai ? noaiiioeyoe?eiiai neeaaeo ?ioiieiiiaoaioieo ee?oei oa
?o ooieoe?iiaeueii? aeoeaiino?. Ioe?iea O-nenoaie e?ioioeeo?a
i?iaiaeeeanue ca aecia/aiiyi aaniethoiiai /enea e?ioioeeo?a ia?eoa?e/ii?
e?ia?, a?aeiinii? oa aaniethoii? e?eueeino? O-e?ioioeeo?a a oano?
niiioaiiiai ?icaoeiooai?aiiy (A-?OE) ca iaoiaeeeith J.Bach oa ni?aaao.
(1969). Noaiiioeyoe?eiee neeaae O-ee?oei aea/aany ca aecia/aiiyi
oaio?e?i/ooeeaeo ? oaio?e?ino?eeeo e?ioioeeo?a (Aoo/-?OE ? Aoon-?OE)
iaoiaeaie J.Bach oa ni?aaao. (1969) ? S.Limatibul oa ni?aaao. (1978).
“Aeoeai?” O-e?ioioeeoe aecia/aeeny iaoiaeii niiioaiiiai ?icaoeiooai?aiiy
(Aa-?OE) ca iaoiaeaie G.Wybran, H.Hudenberg (1973), “oa?iinoaa?euei?”
O-e?ioioeeoe (Aon-?OE) – ca M.Schloesinger (1977). Ooieoe?iiaeueio
aeoeai?noue O-e?ioioeeo?a aea/aee ca aeiiiiiaith ?aaeoe?? aeanoii?
o?ainoi?iaoe?? e?ioioeeo?a (?AOE) c o?oiaaiaaethoei?iii (OAA) ca
iaoiaeeeith J.F.Bach, K.Hirschorn (1969) a iiaeeo?eaoe??
(I.I.A?eai?ueaaa, E.E.Eiiaeyi, 1972). Iae?e ?aaeoe?? i?iaiaeeee
ii?oieia?/iei iaoiaeii. Aecia/aiiy /ooeeaino? aei aetheiei?oeei?ae?a
cae?enithaaee a ?aaeoe?yo ?AOE c OAA a i?enooiino? i?aaei?cieiia
(E.N.Eiainiaa e niaao., 1977). A-nenoaia e?ioioeeo?a aea/aeanue ca
aeiiiiiaith aecia/aiiy aaniethoii? oa a?aeiinii? e?eueeino?
A-e?ioioeeo?a a oano? eiiieaiaioa?iiai ?icaoeiooai?aiiy (AAN-?OE) ca
iaoiaeeeith A.I.*a?aae??aa (1976). Ooieoe?iiaeueio aeoeai?noue
A-e?ioioeeo?a ioe?ithaaee ca ??aiai ?ioiiaeiaoe?i?a eean?a G, M, A a
ne?iaaooe? e?ia? iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca G.Mancini oa
ni?aaao. (1968). Ie??i aecia/aiiy ooieoe?iiaeueii? aeoeaiino?
iaeo?io?eueieo a?aioeioeeo?a (IA) ia?eoa?e/ii? e?ia? ca aeiiiiiaith
oao?acie??aiai oanoo (A.A.Aeaiei, 1976) aoea aeine?aeaeaia oaeiae
iiaeeiaeueia caeaoi?noue oaaioeeooth/eo ee?oei, yea oa?aeoa?ecoaaeanue
iieacieeii oaaioeeoico (IO) ? oaaioeeoa?iei /eneii (O*) (N.A.Iioaiiaa,
A.N.O?oneeeia, 1977). Aecia/aiiy oeeoioiene/ii? aeoeaiino? ee?oei
(i?e?iaeieo e?ea??a – IE ? e?ea??a – E) i?iaiaeeee a oeeoie?oe/i?e
?aaeoe?? (I.O.Iaeueieeia e niaao., 1985).

Aioeaaie nenoaie HLA oeioaaee o oeeoie?oe/iiio oano? ia ieaioaoao
Oa?anae?.

Aeey aecia/aiiy ?ioaineaiino? i?ioean?a ia?aeeniiai ieeniaiiy e?i?ae?a
(IIE) aea/aii ai?no ae??iiaeo eii’thaao?a (AeE), iaeiiiaiai
ae?aeueaeaa?aeo (IAeA) (A.A.Aa?aaie e niaao., 1991); aeoeai?noue
enaioeiieneaeace aecia/aeanue ca D.Della Corte oa ni?aaao. (1969);
aea/aii oaeiae ai?no na/iai? eeneioe a e?ia? ianoaaeaieo aaa?oieo
(M.Milsefari et al., 1979), aeaioi?io (M.Grootweld et al, 1987). Aeey
ioe?iee noaio ieneaeaioii-aioeieneaeaioi? nenoaie e?ia? o aaa?oieo aoa
aea/aiee ai?no a?ao?aeiiiai? eeneioe oa i?iaeoeo?a ?? ieenithaaeueiiai
iaoaaie?cio (Y.Takahashi et al, 1993). ?ioaa?aeueio ?ioi?iaoe?th i?i
noai i?iieneaeaioii-aioeieneaeaioii? nenoaie e?ia? o ianoaaeaieo
io?eioaaee ca aeiiiiiaith a?ioai?ethi?i?noeaioiiai (AOE) iaoiaea
(A.A.Aa?aaie, 1991); oaeiae aeine?aeaeaii no?ee?noue a?eo?ioeeo?a aei
eeneioiiai aaiie?co (E.A.Oa?neia, 1957). Aeey ni?aa?aeiioaiiy i?ioean?a
IIE o oaoiieaoeaioa?iiio eiiieaen? o ne?iaaooe? e?ia? oa ieaoeaio?
aea/aeinue oa?iaioaoeaia (IAAeOI-caeaaeia) oa iaoa?iaioaoeaia
(anei?aaocaeaaeia) ia?aeenia ieeniaiiy e?i?ae?a (TH.A.Aeaaeeie?ia,
A.E.A?/aeia, 1972) c aeayeeie iiaeeo?eaoe?yie (TH.E.Aoaneee, 1978).
I?oioiiae??aeueio oa iinoi?oioiiae??aeueio o?aeoe?? ieaoeaioe aeae?eyee
caaaeueiii?eeiyoeie iaoiaeaie (I.Ae.Auaiei, 1982).

Aaee/eio oaoiiaoa?einueei? o?ainooc?? aecia/aee ca oanoii
Eeaeioaoy?a-Aaoea (I.N.Eooeaiei, 1995), a ?? noi?iue – ca?aeii c
I.E.A?y?aei oa ni?aaao. (1995).

A aenia?eiaio? ae?th ?acon-aioeaaio ia ?aii? aoaie ?icaeoeo ?ioiieo
?aaeoe?e aea/aee a aeeiai?oe? aaia?ae?caoe?? ?ioiii? a?aeiia?ae? o ieoae
e?i?? BALB/c, yeeo ?ioi?coaaee a?eo?ioeeoaie ?acon-iiceoeaieo aeiii??a:
2,5’106 ee?oei, aioo??oiuei/a?aaia aaaaeaiiy ca noaiith 0 (I), 14-oa
(II), 28-ia (III) aeiaa. Ia?aiao?e, ui aeine?aeaeoaaeenue, aecia/aee o
o?ii?/iiio aenia?eiaio? ye a noia??aii?e oa ?aii?e ia??iaee i?ney
ia?aeiii? aeoeaaoe?? ?ioiii? nenoaie (1-oa oa 24-oa aiaeeia
a?aeiia?aeii), oae ? i?ae /an iaeneiaeueii? ?? aeoeaaoe?? – 4-oa aeiaa
i?ney ia?oi? ?ioi?caoe?? oa 7-ia aeiaa i?ney eiaeii? ?ioi?caoe?? – 7-ia
(I), 14-oa (II), 21-oa (III) a?aeiia?aeii.

Aecia/aee oae? e?euee?ni? iieacieee iaae?aoi??a ?ioiii? nenoaie: 1)
noia?i? iaioeaeieaeeio???ie N4/Ae4/A4 – ?aae?i?ioiiei iaoiaeii (RIA) ca
aeiiiiiaith iaai?o o??ie “Amerscham” (Aiae?y); 2) noaa?eueia iio?aeia
i?inoaoeeee?io (PG12) – 6-eaoi PG1a – RIA-iaoiaeii ca aeiiiiiaith iaai?o
o??ie “Amerscham” (Aiae?y); 3) NO2 – noaa?eueia iio?aeia NO.-?aaeeeaea
– a noaiaea?oi?e ?aaeoe?? ca iaoiaeii Y.L.C.Green oa ni?aaao. (1982); 4)
noia?ieneae?aaeeeae (I2-) – ca iaoiaeii M.Nishikimi oa ni?aaao. (1972);
5) ia?aeen aiaeith – noaa?eueia iio?aeia (I2-) – ca iaoiaeii G.Cohen oa
ni?aaao. (1970).

Aeoeai?noue ieneaeaioii? nenoaie (AIN) oanooaaee oeyoii aecia/aiiy:

1) caaaeueii? e?eueeino? SH-a?oi ca G.Eliman oa ni?aaao. (1979), a
oaeiae aeoeaiino? eeth/iaeo oa?iaio?a; 2) noia?ieneaeaeeniooace – (NIAe)
ca iaoiaeii E.N.Aa?oaiyi oa ni?aaao. (1992); 3) eaoaeace ca iaoiaeii
I.A.Ei?iethe oa ni?aaao. (1998); 4) aethoao?iiia?ieneaeace ca iaoiaeii
N.I.Ao?aae/ (1992).

Aeoeai?noue oa?iaio?a iai?io aoai?iioeeaioeae?a aecia/aee ca aeiiiiiaith
niaeo?ioioiiao?e/ieo iaoiae?a, aeei?enoiaoth/e oae? noano?aoe: 1)
5’-ioeeaioeaeaca (5’-N)-GMP-aoaiicei o??ie “Reanal” (NOA) (G.Greger,
1979); 2) aoai?iaeacai?iaca (GD) – aoai?i o??ie “Calbiochem” (NOA)
(W.Yashmineh, 1988); 3) IPM-aeaa?ae?iaaiaca (IPMD) – IPM o??ie “Reanal”
(NOA) (T.Ikegami et al., 1985); 4) GPM-?aaeoeoaca (GPMR) – GMR IMP
o??ie “Reanal” (NOA) (A.A.Eieoiei e niaao., 1987); 5)
io?eiioeeaiceaeoinoi??eaca (PNP) – aoaiicei o??ie “Sigma” (NOA) (H.Cheny
et al., 1989).

Ioeea?iia? eeneioe c aeine?aeaeoaaieo oeaiei aeae?eyee iaoiaeii
Oi?aeoa-Oaiaaoca?a. E?euee?noue ?IE ? AeIE aecia/aee niaeo?ioioiiao?e/ii
(A.N.Nie?ei, 1968), oaeaee?noue a?ineioaco ?IE ? AeIE – ca
?ioaineai?noth aeeth/aiiy i?oee (18-14N) AI?, yeo aaiaeeee
aioo??oiuei/a?aaii ca 10 oa aei aeaaaeaiiy oaa?ei c aenia?eiaioo a aeic?
3,7 IAe ia 100 a iane o?ea.

Aioeo?eiooai?thth/? ee?oeie (AOE) aecia/aee iaoiaeii oethi?anoeaioieo
a?aeaeoe?a (S.A.Bobrovnik, 1986).

Aeine?aeaeoaai? ia?aiao?e aecia/aee a ?ioiieiiiaoaioieo ee?oeiao –
nieaiioeeoao ? iae?ioaaao naeac?iee oa e?ia? aenia?eiaioaeueieo oaa?ei.

Io?eiaiee oeeo?iaee iaoa??ae aoa ia?iaeaiee ca caaaeueiii?eeiyoeie
iaoiaeaie aa??aoe?eii? noaoenoeee (E.N.Eaieineee, 1964). I?e oeueiio
aecia/aeenue na?aaeiy aaee/eia (I), iioeaea na?aaeiuei? aaee/eie (m),
e?eoa??e a??ia?aeiino? (t), ??aaiue cia/ouino? (?). A??ia?aei?noue
iaea?aeaieo ?acoeueoao?a ioe?ithaaee caaaeueiii?eeiyoei iaoiaeii ca
aeiiiiiaith e?eoa??th No’thaeaioa. A??ia?aei?noue aaaaeaeanue
anoaiiaeaiith, yeui aiia aoea ia iaioa 95 % (?

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