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A:aref.doc

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.aeaae. I.I.Aiaiiieueoey

Aiaoei Ieaia Iao??aia

OAeE
618.2:616.15-097+616.155.194.17-053.31:618.33]-07-08-084:57.083.5:577.1

?ioiia?io?i?/i? aniaeoe ae?aaiinoeee, e?eoaaiiy, i?io?eaeoeee
?acon-eiioe?eoii? aaa?oiino? oa aaiie?oe/ii? oai?iae ieiaea oa
iiaiia?iaeaeaiiai.

14.01.01- Aeooa?noai oa a?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i. Aeaae.
I.I. Aiaiiieueoey IIC Oe?a?ie

Iaoeiaee eiinoeueoaio –

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? A?oaiiiia Aieiaeeie? Na?a?eiae/,

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. Aeaae. I.I.Aiaiiieueoey,
caa?aeoth/ee eaoaae?ith aeooa?noaa oa a?iaeieia?? ? 2;

/eai-ei?aniiiaeaio IAI ? AII Oe?a?ie, aeieoi? iaaee/iee iaoe, i?ioani?,
caneoaeaiee ae?y/ iaoee Oe?a?ie, Noaiaie?anueea Aaeeia Einoyioei?aia,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.I.I.Aiaiiieueoey, i?ioani?
eaoaae?e aeooa?noaa oa a?iaeieia?? ? 1;

aeieoi? iaaee/iee iaoe, i?ioani? Aeaoeaae/ Aaeaioeia ?aaeieei?aia,
Iaoeiai-aeine?aeiee ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII,
caa?aeoth/a a?aeae?eo aaa?oieo c aeno?aaai?oaeueiith iaoaeia??th;

aeaaeai?e AII Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? Aooaiei Aaiaae?e
Ieoaeeiaei, ?inoeooo aa?iioieia?? AII Oe?a?ie, caa?aeoth/ee a?aeae?eo
?ioiieia??.I?ia?aeia onoaiiaa-Ee?anueea iaaee/ia aeaaeai?y
i?neyaeeieiiii? ina?oe?i. I.E.Ooi?ea IIC Oe?a?ie, i.Ee?a, eaoaae?a
aeooa?noaa, a?iaeieia?? oa ia?eiaoieia??

Caoeno a?aeaoaeaoueny 20 n?/iy 2000 ?. i 14 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.03 i?e Iaoe?iiaeueiiio
iaaee/iiio oi?aa?neoao? ?i. Aeaae. I.I.Aiaiiieueoey (04004, i.Ee?a,
aoeueaa? O.Oaa/aiea, 17)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. Aeaae. I.I.Aiaiiieueoey IIC Oe?a?ie (04057,
i.Ee?a, aoe. Ciieia?/ia, 3)

Aaoi?aoa?ao ?ic?neaii 18 a?oaeiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i., aeioeaio
A?oianueeee ss.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. I?iaeaia ?ci?ioiii? aaa?oiino? caa??aa? naith
aeooaeuei?noue ia nueiaiaei? ye aeey oai?aoe/iiai, oae ? i?aeoe/iiai
aeooa?noaa o ca’yceo c /anoioith aeaii? iaoieia??, iniaeeainoyie
ia?aa?ao aaa?oiino? ? ?iae?a, aenieeie a?aenioeaie ia?eiaoaeueieo
caoai?thaaiino? e nia?oiino? a?ae aaiie?oe/ii? oai?iae ieiaea ?
iiaiia?iaeaeaiiai (I.E.A?yaa e niaao., 1992; J.W.Dudenhausen, 1992;
M.J.Whittle, 1992; O.A?ean, 1993).

Aeinyaioo? inoaii?i /anii oni?oe o aea/aii? aeaii? i?iaeaie aeicaieeee
cia/ii ?icoe?eoe oyaeaiiy noiniaii ?ioiieia?/ieo a?aeiioaiue iaoa?? e
ieiaea, aeeaoa c?icoi?oe ie?ai? noi?iie iaoiaaiaco ?ioiieia?/iiai
eiioe?eoo, iicia/eoe iia? oeyoe i?io?eaeoeee oa e?eoaaiiy
(A.W.Robertson, 1992; B.Thilaganatan et al, 1992; A.N.A?oaiiiia e
niaao., 1993; I.A.Oea/aiei e niaao., 1996).

Aeei?enoaiiy no/anieo iaoiae?a ioe?iee noaio ieiaea, a oaeiae
i?iaaaeaiiy niaoeeo?/ii? i?io?eaeoeee ?ioiiaeiaoe?iii Rh(D) aeicaieeei
cieceoe ia?eiaoaeueio nia?oi?noue a?ae aaiie?oe/ii? oai?iae. Iaeiae
noaa?e?caoe?y ?? /anoioe, ui a?aecia/a?oueny ca inoaii? ?iee, oi?ie ??
oneeaaeiaiue aeey iiaeaeueoiai ?icaeoeo aeeoeie iaiieaaeeai aeiaaathoue
ae??oaiiy ua ia ?ica’ycaiieo ieoaiue.

Iacaaeia?euei? ?acoeueoaoe e?eoaaiiy ?ci?ioiiiai eiioe?eoo oa eiai
iane?aee?a o iiaiia?iaeaeaieo iaoiiaeai? iaaeinoaoi?i aea/aiiyi ie?aieo
eaiie iaoiaaiaco, a?aenooi?noth ?aii?o e?eoa???a ?icaeoeo aaiie?oe/ii?
oai?iae, i?iaiinoe/ieo oano?a aecia/aiiy nooiaiy oyaeeino? o?aaeaiiy
ieiaea. Ia aei e?ioey c’yniaaia ?ieue ci?i a ?ioiiiio noaoon? iaoa??.

Aeine?aeaeaiiy aieiaiiai eiiieaeno a?noinoi?niino? ethaeeie (HLA)
aeicaieeei anoaiiaeoe HLA-aaiaoe/i? ia?ea?e noeeueiino? aai no?eeino?
aei oeo /e ?ioeo caoai?thaaiue (A.I.Oaaaeei, E.Ae.Na?iaa, 1991;
TH.I.Iaoiia e niaao., 1994). Iaeiae, iaoai?cie ?aae?caoe?? iiaeeeai?
niaaeeiai? noeeueiino?, ui eiio?ieththoueny aaiaie HLA i?e
?acon-nainea?e?caoe??, caeeoathoueny ua iaaeinoaoiuei aea/aieie.

A iniia? aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai eaaeeoue
aaiie?c a?eo?ioeeo?a i?ae aieeaii ?acon-aioeo?e iaoa?? (K.N.Nicolaides,
C.H.Rodeck, 1992; A.I.Aeecee oa ni?aaao., 1996). ?ieue ee?oeiieo iaia?ai
o oeueiio i?ioean? aea/aia iaaeinoaoiuei. Iineeaiiy ia?aeeniiai
ieeniaiiy e?i?ae?a (IIE) i?ecaiaeeoue aei ae?acieo ci?i a
aioeieneaeaioi?e nenoai?, ii?ooo? no?oeoo?ii-ooieoe?iiaeueio
i?aai?caoe?th a?ieia?/ieo iaia?ai ? ? oi?aa?naeueiei iaoai?ciii
o?aaeaiiy ee?oeie. O oeueiio aniaeo? ? aeooaeueiei aea/aiiy i?ioean?a
IIE, noaio a?eo?ioeeoa?ii? iaia?aie o aaa?oieo c ?acon-nainea?e?caoe??th
aeey ioe?iee noaio iai?iieo i?ioean?a, aeyaeaiiy ?aii?o iciae ?o ci?i ?
ae??oaiiy ieoaiiy uiaei ei?aeoe?? iaoaaie?/ieo ii?ooaiue.

Oaeei /eiii, ia nueiaiaei? caeeoathoueny iac’yniaaieie iaoai?cie
?aae?caoe?? niaaeeiai? noeeueiino?, ui eiio?ieothoueny aaiaie HLA, ?ieue
?ioiieia?/ii? ?aaeoeaiino? oa iaoaaie?/ieo ci?i i?aai?cio iaoa?? a
iaoiaaiac? aaiie?oe/ii? oai?iae ieiaea. O ca’yceo c oeei aaaeeeaith
caaea/ath ? c’ynoaaiiy cia/ouino? e oa?aeoa?o aca?iica’yceo ??cieo
iaoai?ci?a aiiainoaco i?e ?acon-eiioe?eo?, ae??oaiiy ieoaiiy uiaei
iaiao?aeiino? ?ioiieia?/ii? oa iaoaaie?/ii? ei?aeoe??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia ca?aeii c ieaiii iaoeiai-aeine?aeii? ?iaioe eaoaae?e aeooa?noaa
oa a?iaeieia?? ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aaneoaoo ?i. aeaae.
I.I.Aiaiiieueoey ? ? o?aaiaioaie ?ia?o “?ic?iaeoe ? ai?iaaaeeoe a
i?aeoeeo ioi?iie caei?ia’y aoaeoeai? iaoiaee i?io?eaeoeee, ae?aaiinoeee
? e?eoaaiiy ano?en?? iiaiia?iaeaeaieo i?e ?acon-eiioe?eo?, aanoic? e
neaaeino? ?iaeiai? ae?yeueiino? c iaoith cieaeaiiy ia?eiaoaeueii?
caoai?thaaiino? oa nia?oiino? (IIC Oe?a?ie, ? aea?aeaaii? ?a?no?aoe??
0194 V 020895, 1992-1994 ??.) ? “Aeine?aeaeaiiy iaae?aoi?ieo iaoai?ci?a
?ioiii? a?aeiia?ae? i?e ?acon-eiioe?eo? c iaoith ?ic?iaee aoaeoeaieo
i?aia?ao?a aeey i?io?eaeoeee oa e?eoaaiiy ?acon-eiioe?eoo i?e
aaa?oiino?” (ia caiiaeaiiy AeEIO Oe?a?ie, ? aea?aeaaii? ?a?no?aoe?? 0194
U 020897, 1994-1996 ??.).

Iaoa ?iaioe. Aea/aiiy ?ioiiaaiaoe/ieo oa ?ioiia?io?i?/ieo aniaeo?a
?aae?caoe?? ?acon-eiioe?eoo, c’ynoaaiiy ie?aieo iaoai?ci?a iaoiaaiaco
oeueiai noaio, ?ic?iaea e?eoa???a ae?aaiinoeee, i?iaiico oa
iaoiaaiaoe/ii? oa?ai?? aeey cieaeaiiy ia?eiaoaeueieo caoai?thaaiino? e
nia?oiino? a?ae aaiie?oe/ii? oai?iae.

Caaea/? aeine?aeaeaiiy

1. Aecia/eoe iniaeeaino? ?ioiieia?/iiai noaoono aaa?oieo i?e
?acon-nainea?e?caoe?? ca e?euee?noth ? ooieoe?iiaeueiith aeoeai?noth
?ioiieiiiaoaioieo ee?oei oa ?o noaiiioeyoe?eiei neeaaeii.

2. Aea/eoe /anoioo ? niieo/aiiy oaiioei?a aaiaoe/ieo nenoai e?ia? aeey
aecia/aiiy a?oi ?eceeo a?aeiinii ?icaeoeo aaaeeeo oi?i aaiie?oe/ii?
oai?iae.

3. C’ynoaaoe ?ioaineai?noue ia?aeeniiai ieeniaiiy e?i?ae?a ?
a?eueii?aaeeeaeueieo i?ioean?a o aaa?oieo c ?acon-nainea?e?caoe??th.

4. I?iaiae?coaaoe aca?iica’ycee i?ae ?ioiiaaiaoe/ieie aa??aioaie,
?ioiiei noaoonii ? iaoaaie?/ieie iniaeeainoyie o aaa?oieo i?e
?acon-eiioe?eo?.

5. Aea/eoe ae?th ?acon-aioeaaio ia ?aii? aoaie ?icaeoeo ?ioiieo ?aaeoe?e
? aecia/eoe eeth/ia? iaoai?cie ?o ?aaoeyoe??.

6. Anoaiiaeoe ee?i?ei-?ioiieia?/i? oa ee?i?ei-a?io?i?/i? e?eoa???
ae?aaiinoeee, i?iaiico ?icaeoeo aaaeeeo oi?i aaiie?oe/ii? oai?iae.

7. Iaa?oiooaaoe aeioe?euei?noue ?ioiieia?/ii? oa iaoaaie?/ii? ei?aeoe??
o aaa?oieo c ?acon-nainea?e?caoe??th; aecia/eoeoa i?eioeeie ??
i?iaaaeaiiy, iieacaiiy oa aoaeoeai?noue.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa io?eiaii aeai? noiniaii
iniaeeainoae ?ioiia?io?i?/iiai aiiainoaco i?e ?acon-eiioe?eo? o
aaa?oieo.

Ia iniia? i?iaaaeaiiai eiiieaeniiai ee?i?ei-?ioiieia?/iiai oa
a?io?i?/iiai aeine?aeaeaiiy aia?oa noi?ioeueiaaia eiioeaioe?y ?icaeoeo
oyaeeeo oi?i aaiie?oe/ii? oai?iae c iiceoe?? aca?iicaeaaeiino? oa
aca?iiiaoiiaeaiino? ?ioii-a?io?i?/iiai noaoono iaoa?einueeiai i?aai?cio.

Aia?oa ?ic?iaeaii iia? ia?aiao?e a?ioai?ethi?i?noeaioiiai aiae?co aeey
ioe?iee i?iieneaeaioii-aioeieneaeaioiiai noaio i?aai?cio, ui aeicaiey?
aeaoaeuei?oa aecia/aoe aeeaeio ? ye?noue iaoaaie?/ieo ii?ooaiue i?e
?acon-eiioe?eo?.

Aia?oa ?ic?iaeaia iaoaiaoe/ia iiaeaeue ioe?iee iaaaciaee ?icaeoeo
aaiie?oe/ii? oai?iae ieiaea ca ?iciiae?eii noeoiiino? ia?aiao??a
ia?aeeniiai ieeniaiiy e?i?ae?a.

Aia?oa anoaiiaeaii aaiaoe/i? ia?ea?e niaaeeiai? noeeueiino? oa aaiaoe/i?
oaeoi?e ?icaeoeo ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? ? ?icaeoeo
aaiie?oe/ii? oai?iae ieiaea e iiaiia?iaeaeaiiai.

Aeaii oai?aoe/ia iaa?oiooaaiiy iiaiai iai?yieo eiiieaeniiai e?eoaaiiy
aaa?oieo c ?acon-nainea?e?caoe??th — naeaeoeaii? ?ioiieia?/ii? oa
iaoaaie?/ii? ei?aeoe??, cai?iiaiiaaiee aeeoa?aioe?eiaaiee i?aeo?ae aei
?? i?ecia/aiiy.

I?aeoe/ia cia/aiiy ?iaioe. Ia iniia? ?ioiiaaiaoe/ieo oa?aeoa?enoee
iaa?oioiaaii ? ooi/iaii a?oie ?eceeo aaa?oieo uiaei ?icaeoeo aaaeeeo
oi?i aaiie?oe/ii? oai?iae.

Anoaiiaeaia ?ioi?iaoe?eia cia/ou?noue ?yaeo ?ioiia?io?i?/ieo iieaciee?a
noaoono ?ci?ioiii? aaa?oii?, cai?iiaiiaaii e?eoa??? ae?aaiinoeee ?
i?iaiico oyaeeino? o?aaeaiiy ieiaea.

Aeiaaaeaii, ui aeei?enoaiiy naeaeoeaii? ?ioiii? oa iaoaaie?/ii?
ei?aeoe?? ciaioo? nooi?iue nainea?e?caoe?? iaoa??, ni?ey? iie?ioaiith
noaio ieiaea ? caaacia/o? iie?auaiiy ia?eiaoaeueieo ?acoeueoao?a.

?ic?iaeaii oa ai?iaaaeaeaii a i?aeoeeo e?eoa??? ?aiiueiai ?icaeoeo
aaiie?oe/ii? oai?iae ? aeai?o ?aoe?iiaeueii? iaoiaaiaoe/ii? oa?ai??
?acon-eiioe?eoo, ui cieaeo? e?euee?noue oyaeeeo oi?i aeaii? iaoieia??.

?ic?iaeaia iaoaiaoe/ia iiaeaeue ioe?iee iaaaciaee ?aae?caoe??
?acon-eiioe?eoo c noeoiiino? ia?aiao??a ia?aeeniiai ieeniaiiy e?i?ae?a
aeicaiey? i?aeaeueoe a??ia?aei?noue i?iaiico aaiie?oe/ii? oai?iae ieiaea
? iiaiia?iaeaeaiiai.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi iaa?oioiaai? oaia,
caaaeaiiy oa iaoiaee aeine?aeaeaiiy, i?iaaaeaii ee?i?ei-eaai?aoi?ia
ianoaaeaiiy ae?iie, aiae?c io?eiaieo ?acoeueoao?a, c?iaeaii i?aenoiee,
aeniiaee ? i?aeoe/i? ?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe?? oa ?o iioae?eiaai?noue. Iaoa??aee
aeena?oaoe?? i?aaenoaaeaii ia 3-io ananithciiio neiiic?oi? c
i?aeia?iaeiith o/anoth (Ee?a, 1987), 8-io ?a?iiaenueeiio eiia?an?
aianoac?ieia?a (Aa?oaaa, 1990), ia IX, X c’?caeao aeooa??a-a?iaeieia?a
Oe?a?ie (Ee?a, 1991; Iaeana, 1996), IV eiia?an? na?oiai? oaaea?aoe??
oe?a?inueeeo e?ea?nueeeo oiaa?enoa (Oa?e?a, 1992), ia Ieaioiao i?aae?iiy
iaoeiaiai oiaa?enoaa aeooa??a-a?iaeieia?a Oe?a?ie (A?iieoey, 1993;
Iieoaaa, 1994), iaoeiai-i?aeoe/i?e eiioa?aioe?? aeooa??a-a?iaeieia?a
Oe?a?ie “Ooieoe?iiaeuei? iaoiaee ae?aaiinoeee a aeooa?noa? ? a?iaeieia??
(Aeiiaoeuee, 1994), ia i?aeia?iaeiiio neiiic?oi? “?ioiieia?y
?ai?iaeoeoe??” (Ee?a, 1996).

Ii oai? aeena?oaoe?? iioae?eiaaii 44 iaoeia? i?aoe?. A oiio /ene? 25
iaoeiaeo noaoae o oaoiaeo aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie, oa 3 a
?ioeo aeaeaiiyo. Ii?yae c oeei, o iaoa??aeao iaoeiaeo eiioa?aioe?e,
c’?cae?a – 26.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 250 noi?.
iaoeiiieno. Neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, 6 ?icae?e?a,
caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e. Aiia ?ethno?iaaia 40
oaaeeoeyie oa 8 ?enoieaie. Nienie e?oa?aoo?ieo aeaea?ae iae?/o? 354
?iaioe, a oiio /ene? 234 a?o/eciyieo oa 120 ?iicaiieo aaoi??a.

INIIAIEE CI?NO ?IAIOE

IAOA??AEE OA IAOIAeE AeINE?AeAEAIIss

Aeey ?ica’ycaiiy iinoaaeaieo caaea/ ianoaaeaii 289 iiaoi?iiaaa?oieo
ae?iie o a?oe? a?ae 18 aei 37 ?ie?a a aeeiai?oe? aaa?oiino?: 44 —
?acon-iiceoeai? ae?iee (I a?oia); 70 — ?acon-iaaaoeai? ae?iee aac iciae
?acon-nainea?e?caoe?? (II a?oia); 94 — ?acon-nainea?e?ciaai? ae?iee, ye?
ia?iaeeee ae?oae aac aaiie?oe/ii? oai?iae (III a?oia); 81 —
?acon-nainea?e?ciaaia ae?iea, aaa?oi?noue o eio?eo caaa?oeeanue
ia?iaeaeaiiyi ae?oae c aaiie?oe/ith oai?iaith (IV a?oia). A
ii??yaiyeueiiio aniaeo? i?iaiae?ciaaii iieacieee, ui aea/aeeny, o 20
caei?iaeo iaaaa?oieo ae?iie. O eiaei?e a?oi? oaeiae aoei ianoaaeaii ?
iiaiia?iaeaeaieo.

Aenia?eiaioaeuei? aeine?aeaeaiiy aeeiiaii ia ieoao e?i?? BALB/c.

Ianoaaeaiiy aaa?oieo aoei eiiieaeniei ? aeeth/aei ee?i?/i?, eaai?aoi?i?
oa ?ino?oiaioaeuei? iaoiae? aeine?aeaeaiiy. An?i ianoaaeaiei
i?iaiaeeeenue caaaeueiii?eeiyo? eaai?aoi?i? aeine?aeaeaiiy: caaaeueiee
aiae?c e?ia?, na/?, aecia/aeanue a?oiiaa oa Rh-iaeaaei?noue, aiae?c
aeae?eaiue ia oei?o, eiaaoeia?aia oa ?i. Noai ieiaea ioe?ithaaee ca
?acoeueoaoaie ea?ae?ioieia?ao?? (EOA), oeueo?acaoeiaiai aeine?aeaeaiiy
(OCAe), a?io?ce/iiai i?io?eth ieiaea, ?acoeueoaoaie aii?i- ?
ei?aeioeaioaco.

?ioiiee noaoon aaa?oieo aea/aee oeyoii eiiieaeniiai aeine?aeaeaiiy
iiioeyoe?eiiai ? noaiiioeyoe?eiiai neeaaeo ?ioiieiiiaoaioieo ee?oei oa
?o ooieoe?iiaeueii? aeoeaiino?. Ioe?iea O-nenoaie e?ioioeeo?a
i?iaiaeeeanue ca aecia/aiiyi aaniethoiiai /enea e?ioioeeo?a ia?eoa?e/ii?
e?ia?, a?aeiinii? oa aaniethoii? e?eueeino? O-e?ioioeeo?a a oano?
niiioaiiiai ?icaoeiooai?aiiy (A-?OE) ca iaoiaeeeith J.Bach oa ni?aaao.
(1969). Noaiiioeyoe?eiee neeaae O-ee?oei aea/aany ca aecia/aiiyi
oaio?e?i/ooeeaeo ? oaio?e?ino?eeeo e?ioioeeo?a (Aoo/-?OE ? Aoon-?OE)
iaoiaeaie J.Bach oa ni?aaao. (1969) ? S.Limatibul oa ni?aaao. (1978).
“Aeoeai?” O-e?ioioeeoe aecia/aeeny iaoiaeii niiioaiiiai ?icaoeiooai?aiiy
(Aa-?OE) ca iaoiaeaie G.Wybran, H.Hudenberg (1973), “oa?iinoaa?euei?”
O-e?ioioeeoe (Aon-?OE) — ca M.Schloesinger (1977). Ooieoe?iiaeueio
aeoeai?noue O-e?ioioeeo?a aea/aee ca aeiiiiiaith ?aaeoe?? aeanoii?
o?ainoi?iaoe?? e?ioioeeo?a (?AOE) c o?oiaaiaaethoei?iii (OAA) ca
iaoiaeeeith J.F.Bach, K.Hirschorn (1969) a iiaeeo?eaoe??
(I.I.A?eai?ueaaa, E.E.Eiiaeyi, 1972). Iae?e ?aaeoe?? i?iaiaeeee
ii?oieia?/iei iaoiaeii. Aecia/aiiy /ooeeaino? aei aetheiei?oeei?ae?a
cae?enithaaee a ?aaeoe?yo ?AOE c OAA a i?enooiino? i?aaei?cieiia
(E.N.Eiainiaa e niaao., 1977). A-nenoaia e?ioioeeo?a aea/aeanue ca
aeiiiiiaith aecia/aiiy aaniethoii? oa a?aeiinii? e?eueeino?
A-e?ioioeeo?a a oano? eiiieaiaioa?iiai ?icaoeiooai?aiiy (AAN-?OE) ca
iaoiaeeeith A.I.*a?aae??aa (1976). Ooieoe?iiaeueio aeoeai?noue
A-e?ioioeeo?a ioe?ithaaee ca ??aiai ?ioiiaeiaoe?i?a eean?a G, M, A a
ne?iaaooe? e?ia? iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca G.Mancini oa
ni?aaao. (1968). Ie??i aecia/aiiy ooieoe?iiaeueii? aeoeaiino?
iaeo?io?eueieo a?aioeioeeo?a (IA) ia?eoa?e/ii? e?ia? ca aeiiiiiaith
oao?acie??aiai oanoo (A.A.Aeaiei, 1976) aoea aeine?aeaeaia oaeiae
iiaeeiaeueia caeaoi?noue oaaioeeooth/eo ee?oei, yea oa?aeoa?ecoaaeanue
iieacieeii oaaioeeoico (IO) ? oaaioeeoa?iei /eneii (O*) (N.A.Iioaiiaa,
A.N.O?oneeeia, 1977). Aecia/aiiy oeeoioiene/ii? aeoeaiino? ee?oei
(i?e?iaeieo e?ea??a — IE ? e?ea??a — E) i?iaiaeeee a oeeoie?oe/i?e
?aaeoe?? (I.O.Iaeueieeia e niaao., 1985).

Aioeaaie nenoaie HLA oeioaaee o oeeoie?oe/iiio oano? ia ieaioaoao
Oa?anae?.

Aeey aecia/aiiy ?ioaineaiino? i?ioean?a ia?aeeniiai ieeniaiiy e?i?ae?a
(IIE) aea/aii ai?no ae??iiaeo eii’thaao?a (AeE), iaeiiiaiai
ae?aeueaeaa?aeo (IAeA) (A.A.Aa?aaie e niaao., 1991); aeoeai?noue
enaioeiieneaeace aecia/aeanue ca D.Della Corte oa ni?aaao. (1969);
aea/aii oaeiae ai?no na/iai? eeneioe a e?ia? ianoaaeaieo aaa?oieo
(M.Milsefari et al., 1979), aeaioi?io (M.Grootweld et al, 1987). Aeey
ioe?iee noaio ieneaeaioii-aioeieneaeaioi? nenoaie e?ia? o aaa?oieo aoa
aea/aiee ai?no a?ao?aeiiiai? eeneioe oa i?iaeoeo?a ?? ieenithaaeueiiai
iaoaaie?cio (Y.Takahashi et al, 1993). ?ioaa?aeueio ?ioi?iaoe?th i?i
noai i?iieneaeaioii-aioeieneaeaioii? nenoaie e?ia? o ianoaaeaieo
io?eioaaee ca aeiiiiiaith a?ioai?ethi?i?noeaioiiai (AOE) iaoiaea
(A.A.Aa?aaie, 1991); oaeiae aeine?aeaeaii no?ee?noue a?eo?ioeeo?a aei
eeneioiiai aaiie?co (E.A.Oa?neia, 1957). Aeey ni?aa?aeiioaiiy i?ioean?a
IIE o oaoiieaoeaioa?iiio eiiieaen? o ne?iaaooe? e?ia? oa ieaoeaio?
aea/aeinue oa?iaioaoeaia (IAAeOI-caeaaeia) oa iaoa?iaioaoeaia
(anei?aaocaeaaeia) ia?aeenia ieeniaiiy e?i?ae?a (TH.A.Aeaaeeie?ia,
A.E.A?/aeia, 1972) c aeayeeie iiaeeo?eaoe?yie (TH.E.Aoaneee, 1978).
I?oioiiae??aeueio oa iinoi?oioiiae??aeueio o?aeoe?? ieaoeaioe aeae?eyee
caaaeueiii?eeiyoeie iaoiaeaie (I.Ae.Auaiei, 1982).

Aaee/eio oaoiiaoa?einueei? o?ainooc?? aecia/aee ca oanoii
Eeaeioaoy?a-Aaoea (I.N.Eooeaiei, 1995), a ?? noi?iue — ca?aeii c
I.E.A?y?aei oa ni?aaao. (1995).

A aenia?eiaio? ae?th ?acon-aioeaaio ia ?aii? aoaie ?icaeoeo ?ioiieo
?aaeoe?e aea/aee a aeeiai?oe? aaia?ae?caoe?? ?ioiii? a?aeiia?ae? o ieoae
e?i?? BALB/c, yeeo ?ioi?coaaee a?eo?ioeeoaie ?acon-iiceoeaieo aeiii??a:
2,5’106 ee?oei, aioo??oiuei/a?aaia aaaaeaiiy ca noaiith 0 (I), 14-oa
(II), 28-ia (III) aeiaa. Ia?aiao?e, ui aeine?aeaeoaaeenue, aecia/aee o
o?ii?/iiio aenia?eiaio? ye a noia??aii?e oa ?aii?e ia??iaee i?ney
ia?aeiii? aeoeaaoe?? ?ioiii? nenoaie (1-oa oa 24-oa aiaeeia
a?aeiia?aeii), oae ? i?ae /an iaeneiaeueii? ?? aeoeaaoe?? — 4-oa aeiaa
i?ney ia?oi? ?ioi?caoe?? oa 7-ia aeiaa i?ney eiaeii? ?ioi?caoe?? — 7-ia
(I), 14-oa (II), 21-oa (III) a?aeiia?aeii.

Aecia/aee oae? e?euee?ni? iieacieee iaae?aoi??a ?ioiii? nenoaie: 1)
noia?i? iaioeaeieaeeio???ie N4/Ae4/A4 — ?aae?i?ioiiei iaoiaeii (RIA) ca
aeiiiiiaith iaai?o o??ie “Amerscham” (Aiae?y); 2) noaa?eueia iio?aeia
i?inoaoeeee?io (PG12) — 6-eaoi PG1a — RIA-iaoiaeii ca aeiiiiiaith iaai?o
o??ie “Amerscham” (Aiae?y); 3) NO2 — noaa?eueia iio?aeia NO.-?aaeeeaea
— a noaiaea?oi?e ?aaeoe?? ca iaoiaeii Y.L.C.Green oa ni?aaao. (1982); 4)
noia?ieneae?aaeeeae (I2-) — ca iaoiaeii M.Nishikimi oa ni?aaao. (1972);
5) ia?aeen aiaeith — noaa?eueia iio?aeia (I2-) — ca iaoiaeii G.Cohen oa
ni?aaao. (1970).

Aeoeai?noue ieneaeaioii? nenoaie (AIN) oanooaaee oeyoii aecia/aiiy:

1) caaaeueii? e?eueeino? SH-a?oi ca G.Eliman oa ni?aaao. (1979), a
oaeiae aeoeaiino? eeth/iaeo oa?iaio?a; 2) noia?ieneaeaeeniooace — (NIAe)
ca iaoiaeii E.N.Aa?oaiyi oa ni?aaao. (1992); 3) eaoaeace ca iaoiaeii
I.A.Ei?iethe oa ni?aaao. (1998); 4) aethoao?iiia?ieneaeace ca iaoiaeii
N.I.Ao?aae/ (1992).

Aeoeai?noue oa?iaio?a iai?io aoai?iioeeaioeae?a aecia/aee ca aeiiiiiaith
niaeo?ioioiiao?e/ieo iaoiae?a, aeei?enoiaoth/e oae? noano?aoe: 1)
5’-ioeeaioeaeaca (5’-N)-GMP-aoaiicei o??ie “Reanal” (NOA) (G.Greger,
1979); 2) aoai?iaeacai?iaca (GD) — aoai?i o??ie “Calbiochem” (NOA)
(W.Yashmineh, 1988); 3) IPM-aeaa?ae?iaaiaca (IPMD) — IPM o??ie “Reanal”
(NOA) (T.Ikegami et al., 1985); 4) GPM-?aaeoeoaca (GPMR) — GMR IMP
o??ie “Reanal” (NOA) (A.A.Eieoiei e niaao., 1987); 5)
io?eiioeeaiceaeoinoi??eaca (PNP) — aoaiicei o??ie “Sigma” (NOA) (H.Cheny
et al., 1989).

Ioeea?iia? eeneioe c aeine?aeaeoaaieo oeaiei aeae?eyee iaoiaeii
Oi?aeoa-Oaiaaoca?a. E?euee?noue ?IE ? AeIE aecia/aee niaeo?ioioiiao?e/ii
(A.N.Nie?ei, 1968), oaeaee?noue a?ineioaco ?IE ? AeIE — ca
?ioaineai?noth aeeth/aiiy i?oee (18-14N) AI?, yeo aaiaeeee
aioo??oiuei/a?aaii ca 10 oa aei aeaaaeaiiy oaa?ei c aenia?eiaioo a aeic?
3,7 IAe ia 100 a iane o?ea.

Aioeo?eiooai?thth/? ee?oeie (AOE) aecia/aee iaoiaeii oethi?anoeaioieo
a?aeaeoe?a (S.A.Bobrovnik, 1986).

Aeine?aeaeoaai? ia?aiao?e aecia/aee a ?ioiieiiiaoaioieo ee?oeiao —
nieaiioeeoao ? iae?ioaaao naeac?iee oa e?ia? aenia?eiaioaeueieo oaa?ei.

Io?eiaiee oeeo?iaee iaoa??ae aoa ia?iaeaiee ca caaaeueiii?eeiyoeie
iaoiaeaie aa??aoe?eii? noaoenoeee (E.N.Eaieineee, 1964). I?e oeueiio
aecia/aeenue na?aaeiy aaee/eia (I), iioeaea na?aaeiuei? aaee/eie (m),
e?eoa??e a??ia?aeiino? (t), ??aaiue cia/ouino? (?). A??ia?aei?noue
iaea?aeaieo ?acoeueoao?a ioe?ithaaee caaaeueiii?eeiyoei iaoiaeii ca
aeiiiiiaith e?eoa??th No’thaeaioa. A??ia?aei?noue aaaaeaeanue
anoaiiaeaiith, yeui aiia aoea ia iaioa 95 % (? < 0,05). ?ic?aooiee i?iaiaeeee ia ia?niiaeuei?e AII. ?acoeueoaoe aiineeenue o eiii’thoa?i? aace aeaieo EXEL 7.0 ? ACCES 7.0. Aeey aea/aiiy aca?iica’yceo aeine?aeaeoaaieo iieaciee?a ca aeiiiiiaith ei?aeyoe?eiiai aiae?co aeei?enoiaoaaeenue iaoaiaoe/i? iaeaoe STATISTICA-5. ?icaeyaeaeenue o?eueee ei?aeyoe?ei? ca’ycee c aeinoia??i?noth p < 0,05. Neaaeee ca’ycie niinoa??aaany i?e eiao?oe??ioao ei?aeyoe?? 0,3, iii??iee - 0,31-0,5, iii?oiee - 0,5-0,7, aenieee - a?eueoa 0,7 (O.A.Anoaoiaa, A.E.Iaaeaaaeaa, 1989). ?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss Aiae?c 8421 ?noi??e ?iae?a, i?iaaaeaieo ia ee?i?/ieo aacao eaoaae?e aeooa?noaa oa a?iaeieia?? ? 2 Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. aeaae. I.I.Aiaiiieueoey, eio?? ooieoe?iioaaee ye niaoe?ae?ciaai? oeaio?e ii aaaeaith aaa?oieo c ?acon-iaaaoeaiei oeiii e?ia? ca 1982-1996 ??., iieacaa, ui ?acon-nainea?e?caoe?y ?icaeaa?oueny o 12,5-13,1 %, a ?acon-eiioe?eo - o 4,1-4,5 % aaa?oieo. Cia/iee a?aenioie (78,2 %) ?cinainea?e?ciaaieo ae?iie noaiiaeyoue iiaoi?iiaaa?oi?; ?acon-nainea?e?caoe?y i?e ia?o?e aaa?oiino? a?aei?/aeany eeoa o 21,8 % ae?iie. Na?aae ieo aoee ae?iee (5,2 %), nainea?e?ciaai? i?ney aaiio?ainooc?e ua aei aaa?oiino?. Aaiie?oe/ia oai?iaa ieiaea ?icaeaaeanue o oeeo ae?iie /ano?oa ? o a?eueo oyaee?e oi?i?, i?ae o ae?iie, nainea?e?ciaaieo o?eueee i?ae /an aaa?oiino?. O ia?oiaaa?oieo, eio?? nainea?e?coaaeeny i?ae /an aaa?oiino?, i?ioe?aconi? aioeo?ea aecia/aeeny ia?aaaaeii a e?ioe? aaa?oiino?. Aiae?c no?oeoo?e AO iieacaa, ui o 1982-1986 ??. ia?aaaaeaea aeiaoooii-iaa?yeiaa, o 1987-1992 ??. - iaa?yeiai-aiai?/ia, o 1992-1996 ??. - aeiaoooii-aiai?/ia oi?ia. Eaaeee nooi?iue ia?aa?ao AO aoa o 40,9-41,06 %, na?aaei?e nooi?iue - o 39,02-40,0, oyaeeee - o 20,45-18,94 %. Ia?eiaoaeuei? ao?aoe neeaaeaee 11,6-13,1 ‰. Oaeei /eiii, ieoiia aaaa oyaeeeo oi?i AO aeineoue aeniea. Ee?i?ei-noaoenoe/iee aiae?c ?noi??e ?iae?a iieacaa, ui niaoeeo?/ia ?ioiii?io?eaeoeea aoea i?iaaaeaia i?ney iieia?a o 87 % ?acon-iaaaoeaieo ae?iie, ye? ia?iaeeee ?acon-iiceoeaieo ae?oae. Aea/aiiy aiaiianoe/ieo aeaieo 289 ianoaaeaieo aaa?oieo iieacaei, ui an? ae?iee iaee ooo/i? aai naiia?euei? aai?oe, ?iaee aai aai?oe ? ?iaee. Na?aae ?acon-nainea?e?ciaaieo e?euee?noue ae?iie, ye? iaee a aiaiiac? ? aai?oe ? ?iaee, aoea aeaui ieae/a, i?ae na?aae ianoaaeaieo aac ?acon-nainea?e?caoe?? ca ?aooiie a?eueo aenieiai a?aenioeo naiia?eueieo aai?o?a. Oneeaaeiaiiy i?ae /an iiia?aaei?o aaa?oiinoae ? ?iae?a iaee 14 % ae?iie I a?oie, 13 % - II, 22 % - III ? 33 % - IV a?oie. Iaeaeuee a?aenioie oneeaaeiaiue i?e iiia?aaei?o ?iaeao niinoa??aaany o ae?iie IV ee?i?/ii? a?oie; iaea?eueo /anoei oneeaaeiaiiyi aoee e?iaioa/? a ?iaeao. Na?aae ianoaaeaieo III i IV a?oi iaoieia?/i? ?iaee a ieioeiio aoee o 18 (19 %) ? 13 (16 %) ae?iie oeeo a?oi, a?aeiia?aeii; aaiio?ainooc?y aoea i?iaaaeaia o 11 (11 %) ae?iie III a?oie ? 12 (15 %) - IV a?oie. Aiae?c aeaieo uiaei oa?aeoa?o ia?aa?ao oaia??oiuei? aaa?oiino? o ianoaaeoaaiiai eiioeiaaioo ae?iie na?ae/eoue, ui o ?acon-nainea?e?ciaaieo aaa?oieo aeineoue /anoi a?aei?/aeenue oae? oneeaaeiaiiy, ye caa?ica ia?a?eaaiiy aaa?oiino? (9,9 % o IV a?oi? i?ioe 2 % o II a?oi?), aiai?y (6 % a IV a?oi?, a eiio?ieuei?e II a?oi? ia aoei ae?iie c aiai??th) ? iniaeeai aoa aenieee a?aenioie /enea aeiaaee?a oaoiieaoeaioa?ii? iaaeinoaoiino? (34,5 % i?ioe 1,4 % a?aeiia?aeii). Aeacai? oneeaaeiaiiy iiaeooue aooe ye naiino?eieie i?e/eiaie oneeaaeiaiiai ia?aa?ao aaa?oiino?, oae ? iane?aeeii ?cinainea?e?ciaaiiai noaio. I?ioe?aconi? aioeo?ea i?eaeecii c iaeiaeiaith /anoioith aecia/aeenue o aaa?oieo III i IV ee?i?/ieo a?oi o I ? II o?eiano?ao. Ne?ae cacia/eoe, ui iaaea eieeaaiue aaee/ei oeo??a aoea ana ae aeua o aaa?oieo IV a?oie, i?ae III (1:2-1:512 ? 1:2-1:64 a?aeiia?aeii). Nooi?iue oyaeeino? aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai ioe?ithaaee o a?aeiia?aeiino? aei iaoiaee/ieo ?aeiiaiaeaoe?e IIC Oe?a?ie “I?io?eaeoeea ?acon-eiioe?eoo ? aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai” (1989). Noiniaii iane?aee?a aaa?oiino? o ae?iie IV a?oie na?ae/aoue, ui noaee?i?/ia oi?ia aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai ?icaeioeanue o 12,5 %, eaaeee nooi?iue - o 26,0, na?aaei?e - o 23,5, oyaeeee - o 16,0 %, aioaiaoaeueia caaeaaeue ieiaea - o 22,0 % aeiaaee?a. A?aoiaoth/e a?aenioie aeiaaee?a aioaiaoaeueii? caaeaae? a?ae aaiie?oe/ii? oai?iae ? a?aenioie oyaeeiai o?aaeaiiy ieiaea, ne?ae cacia/eoe, ui /anoea ?icaeoeo aaaeeeo oi?i aaiie?oe/ii? oai?iae aeineoue aaeeea. C iaoith aea/aiiy aniaeo?a aaiaoe/ii? aeaoa?i?iaoe?? iaoai?ci?a ?acon-eiioe?eoo i?iaaaeaii ii??aiyeueia aeine?aeaeaiiy ?ie? oaeoi??a HLA-anioe?eiaaii? niaaeeiai? noeeueiino? a ?iaeoeoe?? iaoieia?/iiai i?ioeano na?aae ?cinainea?e?ciaaieo aaa?oieo aac ? c ?aae?caoe??th ?acon-eiioe?eoo. Anoaiiaeaii, ui iae/ano?oa o iaoa??a c ?acon-eiioe?eoii aecia/aeenue HLA-aioeaaie eieono A (o ii?yaeeo cia/ouino?): A2, A9, A3; eieono A: A17, A7, A14. A ca’yceo c oei ui ?ioi?iaoeai?o?i ? aeyaeaiiy anioe?aoeaiiai ca’yceo caoai?thaaiiy ia c iaeiei aioeaaiii, a c eiiieaenii aioeaai?a, ie i?iaiae?coaaee oaeiae /anoioo cono??/a?iino? ia? aioeaai?a. A?aecia/aii, ui iae/ano?oa niieo/aeeny aioeaaie eieon?a A ? A, aeaui iaioa - A, ? aeineoue ??aeei - aioeaaie eieono A. Iaeaeuo /anoioo iaei niieo/aiiy HLA-aioeaai?a A2A17. Aioeaaiiee neeaae aaouee?a, ye? aeathoue /anoeio aioeaaiii? ?ioi?iaoe?? ieiaeo, iieacaa, ui a a?oi? aaa?oieo c ?acon-eiioe?eoii o aaouee?a iae/ano?oa oeioaaeeny aioeaaie (o ii?yaeeo cia/ouino?) A9, A10, A5, A14, A40. Aea/aiiy /anoioe ia? aioeaai?a o iiae?oaeaey anoaiiaeei, ui i?e ?acon-eiioe?eo? aoa cia/iee a?aenioie ia? c aeaiia caaaeueieie aioeaaiaie ii eieono A (25,0 %) i?e a?aenooiino? caaaeueieo aioeaai?a ii eieono A. Aeey ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy /anoioiiai aiae?co aoa i?iaaaeaiee eeanoa?iee aiae?c, yeee aea? iiaeeea?oue aeyaeoe ??cii??aei?noue a aaaaoii??iiio i?inoi?? iciae. Aeaoaeueiee aiae?c /anoio aioeaaiieo oa?aeoa?enoee eeanoa??a iieacaa, ui iaeoyae/? oi?ie AOI niinoa??aaeenue o aeiaaeeao, eiee aioeaaiiee niaeo? oeaieie aaoueea i?noea HLA-aioeaai A10, a iaoa?? A2 a ??cieo niieo/aiiyo c ?ioeie aioeaaiaie. I?e ii??aiyeueiiio aiae?c? a?oi eeanoa??a aeey aaouee?a ? iaoa??a a caeaaeiino? a?ae nooiaiy oyaeeino? AOI ie aiaaieeenue, ui iaeoyae/ee ia?aa?a caoai?thaaiiy (aae aei aioaiaoaeueii? caaeaae? ieiaeo) niinoa??aaany i?e iaeii/aniiio niieo/aii? ? o iaoa?? e o aaoueea aioeaai?a HLA A9A14. Io?eiai? aeai? /?oei ocaiaeaeothoueny c aiae?cii anioe?aoeaieo ca’yce?a, ye? na?ae/aoue i?i aenieee ?ecee ?aae?caoe?? ?acon-eiioe?eoo c aioeaaiaie HLA A9 (R=4,0) ? B14 (R=4,4). Aenieee ?ecee ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? iathoue ae?iee c A(II) a?oiith e?ia?. Iaoyaeoth/ei aaiaoe/iei oaeoi?ii ? noi?ni?noue ca a?oiith e?ia? o iiae?oaei?e ia??. Noeeuei?noue aei ?icaeoeo oyaeeeo oi?i AOI anioe?eiaaia c? niieo/aiiyi aioeaai?a HLA A9A14 i?e ?o iaeii/ani?e iaeaaeiino? ? o iaoa??, ? o aaoueea. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue iiaeia i?eionoeoe, ui nooi?iue HLA-aioeaaiii? noi?niino?, ye ? noi?ni?noue ca a?oiith e?ia?, o iiae?oaeaey ia ? ia?oi?yaeiei oaeoi?ii o ?icaeoeo ?acon-eiioe?eoo, aea i?aeaeuo? a??ia?aei?noue oneeaaeiaiaiiai ia?aa?ao ?acon-nainea?e?caoe??. Aecia/aiiy HLA-oaiioeio aeicaiey? aeae?eeoe a?oio ?eceeo aaa?oieo noiniaii ?icaeoeo oyaeeeo oi?i oaeiai aeaeo ?ioiiiaoieia??, ye ?acon-ianoi?ni?noue o iaoa?? ? ieiaea, aeey caaacia/aiiy caoiae?a uiaei ?aiiuei? ae?aaiinoeee ? oe?eani?yiiaaii? i?io?eaeoeee aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai. A ?acoeueoao? ioe?iee noaio ?ioiii? nenoaie iaoa?? aoei anoaiiaeaii, ui ?icaeoie ?acon-eiioe?eoo noi?iaiaeaeo?oueny ci?iith iiioeyoe?eiiai ? noaiiioeyoe?eiiai neeaaeo ?ioiieiiiaoaioieo ee?oei oa ?o ooieoe?iiaeueii? aeoeaiino?. O ae?iie c ?acon-eiioe?eoii o i?ioean? ?icaeoeo aaa?oiino?, ia a?aei?io a?ae ae?iie c o?c?ieia?/iei ia?aa?aii aaa?oiino?, o yeeo niinoa??aa?oueny cieaeaiiy e?eueeino? O-e?ioioeeo?a ii??aiyii c iaaaa?oieie, anoaiiaeaii i?aeaeuaiiy ??aiy ?ioaineaiino? niiioaiiiai ?icaoeiooai?aiiy aaea a I o?eiano??, ??cea i?aeaeuaiiy ??aiy A-?OE o III o?eiano??, ui noaiiaea 50+1,53 % (i?ioe 34,70+1,47 % o aaa?oieo II a?oie oa 41,10+1,80 % o iaaaa?oieo). Cia/ia i?aeaeuaiiy ?ioaineaiino? aeanoiooai?aiiy O-e?ioioeeo?a o a?aeiia?aeue ia OAA niinoa??aaeinue o aaa?oieo c ?acon-eiioe?eoii: aaea o II o?eiano?? iieacieee ?AOE ia OAA o ieo aeinyaee 71,84+0,86 %, ui cia/ii aeua ii??aiyii c ?ioeie a?oiaie aaa?oieo. Iiaeaeueoa ca?eueoaiiy ooieoe?iiaeueii? aeoeaiino? O-e?ioioeeo?a aecia/aeinue o III o?eiano?? (79,0+0,94 % ). Aiae?coth/e iieacieee eiiieaiaioa?iiai ?icaoeiooai?aiiy o aaa?oieo c ?acon-eiioe?eoii, ie anoaiiaeee, ui ii/eiath/e c I o?eiano?a ? aae aei 39-40 oeaeiy aaa?oiino? aaee/eie AAN-?OE aoee aeu?, i?ae a on?o ?ioeo ianoaaeaieo a?oiao aaa?oieo. Oae, o I o?eiano?? oeae iieaciee o aaa?oieo II oa III a?oi aoa i?aeoe/ii iaeiaeiaee ? noaiiaea 14,0+0,99 oa 14,3+1,27 % a?aeiia?aeii. Na?aae aaa?oieo c ?acon-eiioe?eoii ?ioaineai?noue AAN-?OE nyaaea 24,43+1,52 %. O aeeiai?oe? aaa?oiino? a?aei?/aeenue iacia/i? eieeaaiiy ??aiy eiiieaiaioa?iiai ?icaoeiooai?aiiy o aaa?oieo II oa III a?oi, a oie /an ye o aaa?oieo c ?acon-eiioe?eoii a?i aoa a??ia?aeii aeuei ? noaiiaea o II o?eiano?? 21,8+1,19 % ? o III o?eiano?? - 29,17+1,82 % a?aeiia?aeii. I?e aea/aii? ooieoe?iiaeueii? aeoeaiino? A-e?ioioeeo?a ca ai?noii ?ioiiaeiaoe?i?a eean?a G, A, M ie a?aei?oeee, ui o aaa?oieo c ?acon-eiioe?eoii niinoa??aaeenue a?eueo aenie? eiioeaio?aoe?? a ne?iaaooe? e?ia? IgM ? iniaeeai IgG. Aeey aeyaeaiiy ni?aa?aeiinii? ?ie? ?ci?ioi?caoe?? o oi?ioaaii? iniaeeainoae ?ioiii? a?aeiia?ae? aeine?aeaeoaaeenue e?euee?ni? iieacieee ie?aieo noaiiioeyoe?e ?ioiieiiiaoaioieo ee?oei. Iieacaii, ui ia?aa?a aaa?oiino?, yea noi?iaiaeaeoaaeany oi?ioaaiiyi AOI, oa?aeoa?ecoaaany ae?aciith ci?iith noaiiioeyoe?eiiai neeaaeo O-ee?oei, ui ae?aaeaeinue o ??ceiio iaae?ii? /enea oaio?e?i/ooeeaeo e?ioioeeo?a ? i?aeaeuaii? e?eueeino? oaio?e?ino?eeeo ee?oei. Iaeae?aci?o? ci?ie aeacaiiai oa?aeoa?o niinoa??aaeenue o III o?eiano?? aaa?oiino?. Oae, ai?no O-oaeia??a o oeae oa?i?i noaiiaea 36,24+1,2 %, a O-noi?ani??a - 6,8+0,9 %. Iieaciee O-oaeia??a aoa o 1,5-2,0 ?ace aeuee, a O-noi?ani??a - o 1,5-2,0 ?ace ieae/ei ii??aiyii c II oa III a?oiaie. Aeecaaeain ?ioii?aaoeyoi?ieo ee?oei, ui niinoa??aaany i?e ?acon-eiioe?eo?, i?ecaiaeea aei ca?eueoaiiy ni?aa?aeiioaiiy O-oaeia?e / O-noi?ani?e. sseui a a?oiao c o?c?ieia?/iei ia?aa?aii aaa?oiino? oeae ?iaeaen o I ? II a?oiao aoa 1,30 oa 1,13 a?aeiia?aeii, oi i?e ?acon-eiioe?eoi?e aaa?oiino? oea ni?aa?aeiioaiiy ca?eueooaaeinue aei 5,3. Aiae?c ?acoeueoao?a aeine?aeaeaiue c aea/aiiy O-aeoeaieo ? O-noaa?eueieo e?ioioeeo?a iieacaa, ui ?icaeoie ?acon-eiioe?eoii? aaa?oiino? noi?iaiaeaeo?oueny i?aeaeuaiiyi e?eueeino? ye aeoeaieo, oae ? noaa?eueieo O-e?ioioeeo?a ii/eiath/e aaea c I o?eiano?o aaa?oiino?. Iaeaeu? oeeo?e aeacaieo iieaciee?a niinoa??aaeenue o III o?eiano?? aaa?oiino?. Oae, yeui O-aeoeai?-?OE a oeae ia??iae o aaa?oieo II a?oie noaiiaeee 23,9+0,76 %, o III a?oi? - 28,7+0,79 %, oi a IV a?oi? - 45,1+1,31 %; O-noaa?euei? ?OE - 5,1+0,69 %; 5,4+0,56 ? 13,7+1,0 % a?aeiia?aeii. I?e aea/aii? e?iaoeee ei?oecii?acenoaioii? oa ei?oecii/ooeeai? iiioeyoe?e O-e?ioioeeoia o ianoaaeaieo ae?iie ie anoaiiaeee, ui o caei?iaeo iaaaa?oieo a oiae? ?aaeoe?? aeanoii? o?ainoi?iaoe??, yea aeieea? o a?aeiia?aeue ia OAA, aeiaeaaaiiy i?aaei?cieiio aeeeeeaei a??ia?aeii ae?aaeaia i?eai?/oaaiiy aeanoiooai?aiiy. Iaae?iiy ?ioaineaiino? ?AOE ia i?oiaai a i?enooiino? i?aaei?cieiio o ieo noaiiaeei a na?aaeiueiio 67,9 % (iaae? eieeaaiue a?ae 62,3 aei 88,0 %). Ie aaaaeaee, ui e?eoa???i ii/aoeo cieaeaiiy /ooeeaino? e?ioioeeo?a aei aetheiei?oeei?ae?a ? cieaeaiiy ieae/a 60 % ?ioaineaiino? ?AOE ia OAA+i?aaei?cieii. O aaa?oieo c ?acon-eiioe?eoii niinoa??aaeinue ??cea i?eai?/aiiy ei?oecii/ooeeai? noaiiioeyoe??. Na?aaei?e a?aenioie cieaeaiiy ?aaeoe?? ia i?aaei?cieii a oe? no?iee aaa?oiino? aoa anueiai 25,74 % (II o?eiano?) ? 22,65 % (III o?eiano?). sse na?ae/aoue io?eiai? aeai?, a i?ioean? ?icaeoeo o?c?ieia?/ii? aaa?oiino? iathoue i?noea iinooiiaa cieaeaiiy i?e?iaeii? ee?oeiii? oeeoioiene/iino? ? aeayea i?aeaeuaiiy aeoeaiino? E-ee?oei ii??aiyii c iaaaa?oieie ae?ieaie. Aaa?oi?noue c ?acon-eiioe?eoii o III o?eiano?? noi?iaiaeaeoaaeanue ca?eueoaiiyi aeoeaiino? IE-ee?oei aei 43,75+2,82 % ia a?aei?io a?ae aaa?oiino? o ae?iie II oa III a?oi (20,52+2,81 % oa 24,61+1,79 % a?aeiia?aeii). O aaa?oieo c ?acon-eiioe?eoii oaeiae ?a?no?oaaeenue a?eueo aenie? iieacieee E-ee?oeiii? aeoeaiino?, i?ae o aaa?oieo a ii??aithaaieo a?oiao. Iaeae?aci?o? ci?ie a?aecia/aeenue o III o?eiano?? ? o IV a?oi? aiie noaiiaeee 72,10+1,93 %, o II - 60,70+1,67, a III - 68,40+1,54 %. Ine?eueee a iaoai?ciao caoenoo i?aai?cio aaeeea cia/aiiy ia? ee?oeiia ?acenoaioi?noue, iaie aeine?aeaeaiee ooieoe?iiaeueiee noai iaeo?io?eueieo a?aioeioeeo?a ia?eoa?e/ii? e?ia? a on?o a?oiao aaa?oieo a aeeiai?oe? aaa?oiino?. C? ca?eueoaiiyi oa?i?io aaa?oiino? a on?o a?oiao c?inoaea e?euee?noue INO-iiceoeaieo ee?oei. Iaeaeu? iieacieee e?eueeino? INO-iiceoeaieo ee?oei ?a?no?oaaeenue o III o?eiano??, aea iaea?eueoeie aiie aoee o ae?iie c ?acon-eiioe?eoii (INO aei??aithaaa 82,2+2,6 % ii??aiyii c 44,0+3,8 % o aaa?oieo II a?oie oa 68,0+2,9 % a III a?oi?). Aiae?coth/e io?eiai? aeai? c? noaio ?ioiieia?/ii? ?aaeoeaiino? ianoaaeaieo ae?iie, ie aeae?eeee iae?ioi?iaoeai?o? iieacieee, ui oa?aeoa?ecothoue ?icaeoie ?acon-eiioe?eoo. ?o ae?aci?noue i?e ??cieo aa??aioao ia?aa?ao aaa?oiino? i?aaenoaaeaia a oaae. 1. Oaaeeoey 1 Ae?aci?noue (%) ?ioiieia?/ieo iieaciee?a i?e ??cieo aa??aioao ia?aa?ao aaa?oiino? Aa??aio ia?aa?ao aaa?oiino?O?e-iano? IE EAoo/-?OE?AOE ia OAA+i?aae-i?cieiiNa?aaei?e % ?aaeoe?? ia i?aaei?cieii O?c?ieia?/iaII 23,86 +1,0* 61,10 +1,78 14,4 +1,2* 27,94 +1,39*58,61III 20,52 +2,81* 60,70 +1,67 15,6 +0,89* 32,96 +1,04*47,17 ?acon-II 40,72 +1,56* ** 69,20 +2,16* ** 8,5 +0,8* ** 52,63 +1,0* **26,94eiioe?eoIII 43,75 +1,82* ** 72,10 +1,93* ** 6,8 +0,9* ** 61,11 +0,94* **21,15Iaaaa?oi? 35,07 +2,37 55,81 +2,27 24,40 +1,42 24,40 +1,4267,90 * A??ia?aei? a?aei?iiino? iieaciee?a ii??aiyii c iaaaa?oieie. ** A??ia?aei? a?aei?iiino? i?ae a?oiaie ii o?eiano?ao. I?e aecia/aii? nooiaith ?ioi?iaoeaiino? anoaiiaeaieo iieaciee?a ie c’ynoaaee, ui cieaeaiiy aeoeaiino? IE-ee?oei ia oii? iii??iiai i?aeaeuaiiy aeoeaiino? E-ee?oei, c?inoaiiy e?eueeino? O-noi?ani??a oa iacia/ia ciaioaiiy /ooeeaino? O-e?ioioeeo?a aei aetheiei?oeei?ae?a a?aei?/aeinue i?e o?c?ieia?/iiio ia?aa?ao aaa?oiino? iaeaea o 83,7 % ae?iie aac ?acon-nainea?e?caoe??. Iaeii/ania i?aeaeuaiiy IE ? E-ee?oei e cieaeaiiy O-noi?ani??a oa cia/ia i?eai?/aiiy /ooeeaino? O-e?ioioeeo?a aei aetheiei?oeei?ae?a niinoa??aaeinue o 77,4 % ae?iie c ?acon-eiioe?eoii. A on?o a?oiao ianoaaeaieo a?aei?/aeanue caaaeueia oaiaeaioe?y aei i?aeaeuaiiy ai?noo i?iaeoeo?a IIE (IAeA ? AeE o ne?iaaooe? e?ia? aaa?oieo). Niinoa??aaeinue a??ia?aeia ca?eueoaiiy ai?noo aeacaieo i?iaeoeo?a o aaa?oieo c ?acon-eiioe?eoii, iniaeeai o III o?eiano??. Oae, iieaciee AeE o aaa?oieo IV a?oie noaiiaea 140,4+3,1 iiieue/ ie, o II a?oi? - 126,8+2,7, o III - 132+2,9 iiieue/ ie; ??aaiue IAeA aoa a?aeiia?aeii 15,70+0,48; 13,50+0,52 ? 9,65+0,65 ie/ie. Noai IIE o ne?iaaooe? e?ia? oa ieaoeaio? ianoaaeaieo aaa?oieo aea/aiee oaeiae ca i?ioeanaie oa?iaioaoeaiiai (IAAeOI-caeaaeiiai - ICI) ? iaoa?iaioaoeaiiai (anei?aaocaeaaeiiai) ia?aeeniiai ieeniaiiy e?i?ae?a (ACI). ?acoeueoaoe aeine?aeaeaiiy iaaaaeai? a oaae. 2. Oaaeeoey 2 I?ioeane ia?aeeniiai ieeniaiiy e?i?ae?a (ieiieue IAeA/e) a ne?iaaooe? e?ia? ianoaaeaieo aaa?oieo A?oia ianoaaeaieoE?euee?noueICIACIIa?i?oe?eiaaia IIEII2513,71±0,50,23+0,064,90±0,03III3015,68±0,8 *1,83±0,095,38±0,05 *IV2519,18±0,9 * **9,90±0,23 * **4,09±0,02 * ** * A??ia?aeia ??cieoey ii??aiyii c eiio?ieai (II a?oiith) (p < 0,05). ** A??ia?aeia ??cieoey i?ae III ? IV a?oiaie (p < 0,05). I?e ?icaeoeo ?acon-nainea?e?caoe?? ia? i?noea a??ia?aeia iineeaiiy i?ioean?a ye oa?iaioaoeaiiai, oae ? iaoa?iaioaoeaiiai ia?aeeniiai ieeniaiiy e?i?ae?a a ne?iaaooe? e?ia? ii??aiyii c oaeei o aaa?oieo II a?oie. Aea ??aaiue IAAeO- ? anei?aaocaeaaeiiai IIE o aaa?oieo c ?acon-eiioe?eoii iaeaea o 5 ?ac?a aeuee, i?ae o aaa?oieo III a?oie, i?i ui na?ae/eoue ni?a?aeiioaiiy iieaciee?a ACI aei ICI a oeeo a?oiao. Oaeei /eiii, i?e ?acon-nainea?e?caoe?? iineeththoueny i?ioeane IAAeOI- oa anei?aaocaeaaeiiai e?iiia?aieeniaiiy, i?e/iio ?aae?caoe?y ?acon-eiioe?eoii? neooaoe?? c ?icaeoeii AO oa?aeoa?eco?oueny cia/iith ae?aaeai?noth oeeo i?ioean?a. ?acoeueoaoe aeine?aeaeaiiy i?ioean?a ia?aeeniiai ieeniaiiy a ne?iaaooe? e?ia? iiaiia?iaeaeaieo iiaeaii a oaae. 3. sse aeieeaa? c iaaaaeaieo aeaieo, o iiaiia?iaeaeaieo c AO aoei a??ia?aeia i?aeaeuaiiy IAAeOI-caeaaeiiai (ICI) (aei 19,89+ 1,12 ieiieue IAeA/e) ? anei?aaocaeaaeiiai (ACI) e?iiia?aieeniaiiy (aei 1,40+ 0,09 ieiieue IAeA/e) ii??aiyii ?c caei?iaeie iiaiia?iaeaeaieie (15,77+1,09 ieiieue IAeA/e ? 0,18+0,04 ieiieue IAeA/e a?aeiia?aeii). Aiaeii/an ??aaiue ia?i?oe?-eiaaiiai IIE aoa a??ia?aeii ieae/a ? noaiiaea o iiaiia?iaeaeaieo c AO 4,14+0,1 ieiieue IAeA/e i?ioe 4,42+0,09 ieiieue IAeA/e o caei?iaeo iiaiia?iaeaeaieo. Ioaea, ?icaeoie aaiie?oe/ii? oai?iae o ieiaea ? iiaiia?iaeaeaiiai noi?iaiaeaeo?oueny aeoea?caoe??th i?ioean?a IIE o ne?iaaooe? e?ia?, ye?, iiaeeeai, iia’ycai? ia eeoa c iineeaiiyi caoenieo iaoai?ci?a, a e iaoieia?/ieie i?ioeanaie, ui iaoyaeothoue noai o?aaeaiiai ieiaea oa iiaiia?iaeaeaiiai. Oaaeeoey 3 I?ioeane ia?aeeniiai ieeneaiiy e?i?ae?a (ieiieue IAeA/e) a ne?iaaooe? e?ia? iiaiia?iaeaeaieo Ianoaaeai? iiaiia?iaeaeai? E?euee?noueICIACIIa?i?oe?eiaaia IIECaei?ia?2315,77±1,090,18+0,044,42±0,09C aaiie?oe/iith oai?iaith2019,89±1,12 *1,40±0,09 *4,14±0,10 * * A??ia?aeia ??cieoey i?ae a?oiaie (p<0,05) A i?oioiiae??yo ? iinoi?oioiiae??aeueieo o?aeoe?yo ieaoeaio aea/ai? i?ioeane ICI ? ACI, a oaeiae ??aaiue ia?i?oe?eiaaiiai IIE (oaae. 4). Cacia/ai? aeai? na?ae/aoue i?i ?ioaineo?eaoe?th ieenithaaeueii-a?aeiiaieo i?ioean?a a ieaoeaio? i?e ?icaeoeo ?acon-nainea?e?caoe??. Aecia/aeiny i?aeaeuaiiy a i?oioiiae??yo ieaoeaio ae?iie III a?oie ICI aei 3,23+0,009 ieiieue IAeA/ia a?eea 30 oa, ACI aei 0,64±0,001 IAeA/ia a?eea 30 oa ? ??aiy ia?i?oe?eiaaiiai IIE aei 0,88+0,002 ieiieue IAeA/ia a?eea 30 oa ii??aiyii c oaeeie iieacieeaie o aaa?oieo eiio?ieueii? a?oie. Oaaeeoey 4 Ia?aeenia ieeniaiiy e?i?ae?a (ieiieue IAeA/ia a?eea, 30 oa) o i?oioiiae??yo ? iinoi?oioiiae??aeueieo o?aeoe?yo ieaoeaio ianoaaeaieo ae?iie A?oia E?eue-I?oioiiae???Iinoi?oioiiae??aeueia o?aeoe?yianoa- aeaieoe?noue ianoa- aeaieo ICI ACIia?i?oe?-eiaaia IIE ICI ACI ia?i?oe?eiaaia IIEII 21 2,85 ±0,01 0,02 +0,001 0,70 ±0,002 2,18 ±0,01 0,01 +0,001 0,78 ±0,001III24 3,23 ±0,009 * 0,64 ±0,001 * 0,88 ±0,002 * 2,89 ±0,02 * 0,53 ±0,001 * 0,66 ± 0,002 *IV19 2,80 ±0,007 ** 0,17 ±0,001* ** 0,78± 0,002* ** 1,84 ±0,01* ** 0,11 ±0,001* ** 0,64 ±0,003 * * A??ia?aeia ??cieoey ii??aiyii c eiio?ieai (p < 0,05). ** A??ia?aeia ??cieoey i?ae II ? III a?oiaie (p < 0,05). ? a i?oioiiae??yo, ? a iinoi?oioiiae??aeuei?e o?aeoe?? ieaoeaio ae?iie III a?oie a?aecia/aeiny i?aeaeuaiiy aeoeaiino? IAAeO- ? anei?aaocaeaaeiiai IIE ia oii? aenieiai ??aiy ia?i?oe?eiaaiiai IIE. A oie aea /an o ?acon-nainea?e?ciaaieo IV a?oie aeyaeaii a??ia?aeia cieaeaiiy aeoeaiino? IAAeO- ? anei?aaocaeaaeiiai IIE ii??aiyii ye c eiio?ieueiith a?oiith, oae ? c aaa?oieie III a?oie, ui na?ae/eoue i?i aeniaaeaiiy eiiiainaoi?ieo iaoaaie?/ieo i?ioean?a o oeaieiao ieaoeaioe. Ii?oieia?/iei i?aeoaa?aeaeaiiyi ?icaeoeo oyaeeeo oi?i aaiie?oe/ii? oai?iae aoa eiiieaen oa?aeoa?ieo ci?i a ieaoeaio?, ye? i?aaenoaaeyee oeiia? i?iyae ii?ooaiue ?ioiieia?/iiai aa?’??a ieaoeaioe. ?acoeueoaoe aeine?aeaeaiiy aeoeaiino? enaioeiieneaeace a e?ia? ianoaaeaiiai eiioeiaaioo ae?iie na?ae/aoue i?i /?oeo oaiaeaioe?th aei i?aeaeuaiiy aeoeaiino? aeaiiai oa?iaioo i?e o?c?ieia?/iiio ia?aa?ao aaa?oiino?. A III i IV a?oiao ianoaaeaieo iaee i?noea a?eueo aenie? iieacieee aeoeaiino? enaioeiieneaeace, i?ae a I, II ? eiio?ieuei?e a?oiao. Ne?ae cacia/eoe, ui a aeeiai?oe? aaa?oiino? c? c?inoaiiyi oyaeeino? AOI niinoa??aaeinue i?aeaeuaiiy enaioeiieneaeacii? aeoeaiino? e?ia? o aaa?oieo c ?acon-eiioe?eoii. O aeiaaeeao aioaiaoaeueii? caaeaae? ieiaea i?aeaeuaiee ??aaiue aeoeaiino? enaioeiieneaeace caa??aaany aae aei ?iaei?ica’ycaiiy. Oaeei /eiii, i?ae nooiaiai oyaeeino? AOI ? aeoeai?noth enaioeiieneaeace niinoa??aa?oueny /?oeee aca?iica’ycie, yeee a?aeaeaa? oyaee?noue ?acon-eiioe?eoo, ui ?icaeioany. Aeeiai?ea ci?ie ai?noo aeaioi?io a e?ia? aaa?oieo ianoaaeaieo a?oi na?ae/eoue, ui i?ioyaii aaa?oiino? ia? i?noea cieaeaiiy eiioeaio?aoe?? aeaioi?io a on?o a?oiao aaa?oieo. Iaeieae/? ??ai? a e?ia? niinoa??aaeenue o ae?iie c ?acon-eiioe?eoii. Ie a?aei?oeee, ui nooi?iue oyaeeino? aaiie?oe/ii? oai?iae /?oei ei?aeth? c iieacieeii aeaioi?io a e?ia?. Aiae?coth/e io?eiai? aeai? ai?noo na/iai? eeneioe ? aeaioi?io aeey oa?aeoa?enoeee ieneaeaioii-aioeieneaeaioii? nenoaie i?aai?cio ianoaaeaiiai eiioeiaaioo aaa?oieo, ie aiaaieeenue, ui ie?aii acyo? oe? iieacieee iathoue ?iaeea?aeoaeuei? eieeaaiiy, aiane?aeie /iai aiie iaaeinoaoiuei ?ioi?iaoeai?. Iaeiae aaee/eia ni?aa?aeiioaiiy na/iai? eeneioe aei aeaioi?io, ye aeyaeeinue, aeineoue /?oei ei?aeth? c oyaee?noth ?acon-nainea?e?caoe??. I?e ?icaeoeo AOI aaee/eia ni?aa?aeiioaiiy na/iaa eeneioa/aeaioi?i (UA/A) ca?eueooaaeanue o na?aaeiueiio a?eueoa i?ae oaea?/? ? noaiiaeea 12,78+1,03. Ie aiaaieeenue, ui oey aaee/eia ii?iaiaa, ? cia/aiiy, ui ?? ia?aaeuothoue, na?ae/aoue i?i caa?ico aaiie?oe/ii? oai?iae ieiaea. Ca?eueoaiiy a e?ia? ai?noo a?eueii? a?ao?aeiiiai? eeneioe ? i?iaeoeo?a ?? iaoaaie?cio aaaaea?oueny iaei??th c oa?aeoa?ieo iciae ?ioaineo?eaoe?? i?ioean?a IIE ? a?eueii?aaeeeaeueiiai ieeniaiiy. O ca’yceo c oeei aeey ioe?iee noaio ieneaeaioii-aioeieneaeaioii? nenoaie e?ia? aoa aea/aiee ai?no a?ao?aeiiiai? eeneioe ? i?iaeoeo?a ?? ieenithaaeueiiai iaoaaie?cio o ianoaaeoaaiiai eiioeiaaioo aaa?oieo. Anoaiiaeaii, ui ?aae?caoe?y ?acon-eiioe?eoo noi?iaiaeaeo?oueny a??ia?aeiei ca?eueoaiiyi ai?noo a e?ia? a?ao?aeiiiai? eeneioe ? i?iaeoeo?a ?? ia?aeeniiai ieeniaiiy. A??ia?aeia ??cieoey o aaee/eiao oeeo iieaciee?a a?aei?/aeanue aaea na?aae aaa?oieo II i III a?oi, ui na?ae/eoue i?i iai?oaeaiiy ieneaeaioii-aioeieneaeaioii? nenoaie o ?cinainea?e?ciaaieo aaa?oieo. Na?aae i?iaeoeo?a ieenithaaeueiiai iaoaaie?cio a?ao?aeiiiai? eeneioe iniaeeai ae?acii (iaeaea o aea?/?) ci?ithaaany ai?no ?cieueiaaieo iiaea?eieo ca’ce?a (?IC) o aaa?oieo c ?acon-eiioe?eoii ii??aiyii c oaeei o aaa?oieo aac iciae ?acon-nainea?e?caoe??. Ca?eueooaaany oaeiae ai?no ? ae??iiaeo eii’thaao?a, ia ui aeacoaaeinue ?ai?oa. Ia iao iiaeyae, a?aeiioaiiy ai?noo ?IC ? a?ao?aeiiiai? eeneioe (?IC / AA) iiaea neoaeeoe iieacieeii ae?aaiinoeee oa i?iaiico iani?eyoeeaiai iane?aeeo aeey ieiaea. ?ioaa?aeueio ?ioi?iaoe?th i?i noai i?iieneaeaioii-aioeieneaeaioii? nenoaie e?ia? ianoaaeaiiai eiioeiaaioo aaa?oieo ie io?eioaaee ca ?acoeueoaoaie aecia/aiiy a?ioai?ethi?i?noeaioe?? e?ia?. Ci?ie ?yaeo iieaciee?a e?ia? ?acon-nainea?e?ciaaieo aaa?oieo c ?aae?caoe??th eiioe?eoo na?ae/aoue i?i ca?eueoaiiy a?eueii?aaeeeaeueieo i?ioean?a ? aaee/eie IIE. Oe? ci?ie eaaeaoue a iniia? iacai?ioiueiai ii?ooaiiy iaia?ai a?eo?ioeeo?a ia o?eueee ieiaea, aea e iaoa??, i?i ui na?ae/eoue oaeee aaaeeeaee iieaciee oe?e?niino? iaia?ai a?eo?ioeeo?a, ye ?o no?ee?noue aei eeneioiiai aaiie?co. I?iaiae?coaaaoe eeneioi? a?eo?ia?aie nooe?eueii? e?ia? aaa?oieo ae?iie o ??ci? oa?i?ie aaa?oiino?, iiaeia c?iaeoe aeniiaie i?i a?aei?iiino? o oi?i? e?eaeo ?iciiae?eo a?eo?ioeeo?a ca no?ee?noth aei eeneioiiai aaiie?co i?e iayaiino? ?acon-eiioe?eoo ? i?e eiai a?aenooiino? (?en. 1). Iaea?eueo? a?aei?iiino? noinothoueny aenioe aaeeeiai oieey, yeee oa?aeoa?eco? iaeneiaeueio aaee/eio a?aenioea a?eo?ioeeo?a aeaii? no?eeino?, a oaeiae /ano ii/aoeo e e?ioey ?o eeneioiiai aaiie?co. Ia i?aenoaa? io?eiaieo aeaieo iiaeia c?iaeoe caeeth/aiiy, ui i?e aaa?oiino?, yea ia?aa?aa? ii?iaeueii o ianainea?e?ciaaieo ae?iie, iacaeaaeii a?ae ?? oa?i?io na?aaeiy aaee/eia aenioe oieey ia nionea?oueny ieae/a 20 %, a eiai aa?oiy iaaea ciaoiaeeoueny a iaeano? 25 %. I?e ??cieo oa?i?iao aaa?oiino?, oneeaaeiaii? ?acon-eiioe?eoii, aenioa oieey, yeee oa?aeoa?eco? iaeneiaeueiee a?aenioie a?eo?ioeeo?a aeaii? no?eeino?, cia/ii ieae/a - 20 %. I?e iayaiino? ?acon-eiioe?eoo /an ii/aoeo aaiie?co cnoaa?oueny ia 1,5 oa, ? c’yaey?oueny iaaaeeeee /?oeee aeiaeaoeiaee oieeue ia 1,5-3 oaeeeiao, ui iia’ycaia c? c’yaeaiiyi ianoaa?eueii? iiioeyoe?? a?eo?ioeeo?a. I?e oeueiio iiaeiaaeo?oueny caaaeueiee /an aaiie?co. Ana oea na?ae/eoue i?i aeeaie? no?oeoo?i? ci?ie a iaia?aiao a?eo?ioeeo?a i?e aaa?oiino?, oneeaaeiai?e ?acon-eiioe?eoii. Oaeei /eiii, aenioa iaeneiaeueiiai oieey ia eeneioieo a?eo?ia?aiao ? ii/aoeiaee /an aaiie?co a?eo?ioeeo?a iiaeooue neoaeeoe ?aii?i ae?aaiinoe/iei ? i?iaiinoe/iei oanoii ?icaeoeo aaiie?oe/ii? oai?iae ieiaea. Ioaea, c ?icaeoeii aaiie?oe/ii? oai?iae ?aae?caoe?y ?acon-eiioe?eoii? neooaoe?? noi?iaiaeaeo?oueny iaia?aiiith iaoieia??th a on?o eaieao nenoaie iaoe-ieaoeaioa-ie?ae. Cia/ia aeoeaaoe?y i?ioean?a IIE, o oiio /ene? a?eueii?aaeeeaeueiiai ieeniaiiy, c iaeiie/aiiyi o e?ia? a?ieia?/ii aeoeaieo ?a/iaei, ??aaiue yeeo c?inoa? a?aeiia?aeii aei nooiaiy oyaeeino? ?acon-nainea?e?caoe??, na?ae/eoue i?i eiiiainaoi?ia iai?oaeaiiy caoenieo iaoai?ci?a, oiae? ye cieaeaiiy ?ioaineaiino? oeeo i?ioean?a, eiia??ii, aeaco? ia ?o aeniaaeaiiy. Oaeei /eiii, iiaeia c?iaeoe aeniiaie, ui ?icaeoie AOI i?ecaiaeeoue aei aca?iicaeaaeiiai ia?a?iciiae?eo cia/aiue ia?aiao??a IIE. Ni?yiiaai?noue oeeo ci?i oa?aeoa?eco? i?ioeane, iia’ycai? c ?ioiiith aa?an??th iaoa?? ii a?aeiioaiith aei ieiaeo. Iaie ?ic?iaeaia iaoaiaoe/ia iiaeaeue ioe?iee iaaaciaee ?icaeoeo AOI c o?aooaaiiyi noeoiiino? iieaciee?a IIE. Aiia a?aoiaoaa? ?iciiae?e 21 ia?aiao?a, ui oa?aeoa?eco? IIE: 2 caaaeueiii?eeiyoeo ia?aiao?a a?ioai?ethi?i?noeaioe?? (AOE) (?ioaineai?noue na?o?iiy oa na?oeinoia) ? 7 aia?oa ?ic?iaeaieo ia?aiao??a (iiooaei?noue na?o?iiy, iai?aoe?eia na?o?iiy, oaeaee?noue iaae?iiy, ii?iiaaia oaeaee?noue iaae?iiy, oaeaee?noue c?inoaiiy, ii?iiaaia oaeaee?noue ia?inoaiiy, eiao?oe??io neiao???), 10 - a?io?i?/ieo ? 3 - eeneioeo a?eo?ia?ai. ?ic?aoiaaii aaaia? eiao?oe??ioe aeey eiaeii? a?oie ia?aiao??a ? anueiai ?o ae?aiaciio. Ia iniia? ?ic?iaeaii? iiaeae? aoee ia/eneai? ?iaeea?aeoaeuei? ?eceee ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? o aaa?oieo. Aeei?enoaiiy aia?oa ?ic?iaeaieo iieaciee?a i?aeaeueei a??ia?aei?noue ia?aaeaa/aiiy ?icaeoeo AO c 33 aei 87 %. Aeey c’ynoaaiiy iaoai?ci?a ?icaeoeo ?ioiii? a?aeiia?ae? ia ?acon-aioeaai oa oeyo?a ?? ?aaoeyoe?? a aenia?eiaio? aeine?aeaeaii iaae?aoi?i? iaoai?cie, ye? oi?iothoue oei ?ioiii? ?aaeoe?? i?e ae?? ?acon-aioeaaio. Anoaiiaeaii, ui a?ineioaco aioe?acon-aioeo?e (IgG) ia?aaeo? aeoeaaoe?y ?ioiii? nenoaie. Inoaiiy, ye iieacaee iao? aeine?aeaeaiiy, cae?enith?oueny a ?ioiieiiiaoaioieo ee?oeiao a oiio /ene? e ca ?aooiie aeoeaaoe?? oinoie?i?aeii? neaiaeueii? nenoaie. Iaeiei c ?aaoeyoi??a ?icaeoeo ?ioiii? ?aaeoe?? ? ?ic/eiia aoai?eaooeeeeaca, yea ca’ycaia c oinoie?i?aeiith neaiaeueiith nenoaiith /a?ac i?iaeoeoe a?eueii?aaeeeaeueiiai ieeniaiiy a?ao?aeiiiai? eeneioe - eaeeio???ie ? i?inoaaeaiae?ie, a oaeiae a?euei? ?aaeeeaee - I2-, NO, OH, ui i?iaeoeothoueny aeoeaiaaieie iae?ioaaaie ii e?i?aeiiio ? ioeeaioeaeiiio eaiaeo e eiio?ieththoueny AIN (a oiio /ene? oa?iaioaie NIAe, eaoaeacith, aethoao?iiia?ieneaeacith ? ai?noii a?eueieo SH-a?oi). Aeeiai?ea ci?i e?eueeino? aeoeaieo oi?i eenith a ?ioiieiiiaoaioieo ee?oeiao ? e?ia? iaoiiaeaia aieeaii aioeieenithaaeueii? nenoaie (AIN). ?acoeueoaoe aea/aiiy aeoeaieo oa?iaio?a nenoaie AIN i?ney ?ioi?caoe?? ?acon-aioeaaiii i?aaenoaaeai? a oaae. 5. Iiaeia aaaaeaoe, ui iaeiei c iaoai?ci?a ?aaoeyoe?? ?ioiii? a?aeiia?ae? ia ?acon-aioeaai iiaea aooe naia iiaeoeyoe?y a?eueii?aaeeeaeueieo i?ioean?a ia an?o aoaiao ?ioiii? a?aeiia?ae? aai iiaeoeyoe?y iai?io aoai?i-ioeeaioeae?a, ye? eiio?ieththoue ye aoai a?ineioaco a?eeiaeo iieaeoe aioe?acon-IgG, oae ? aoaie, ui ?i ia?aaeothoue, ii/eiath/e c ia?aaea/? ia?aeiiiai neaiaeo ?acon-aioeaaio ia oinoie?i?aeio neaiaeueio nenoaio, eio?a ?i?oe?th? ?ioiiee eaneaae. A caeaaeiino? a?ae aaaeaieo ?acoeueoao?a iiaeia iineaaeoe (o aeiaaeeo aeanainea?e?caoe?? i?e aaa?oiino?) aai i?aeneeeoe (o aeiaaeeo a?ia??ioi?caoe?? aeiii??a) aenioo aoii?aeueii? a?aeiia?ae? a i?ioean? ?? aaia?ae?caoe?? ia ?acon-aioeaai. Ia i?aenoaa? aenia?eiaioaeueieo aeaieo aeine?aeaeaia iiaeeea?noue i?aeneeaiiy aoii?aeueii? a?aeiia?ae? o aenia?eiaioaeueieo oaa?ei aeey io?eiaiiy ne?iaaoie c aenieei oeo?ii aioe?acon- ?en. 1. Aeeiai?ea ci?ie eeneioieo a?eo?ia?ai o ianoaaeaieo aaa?oieo: a- aaa?oi? c ?acon-iiceoeaiei oeiii e?ia?; a-a - aaa?oi? c ?acon-nainea?e?caoe??th; ae - aaa?oi? c ?acon-iaaaoeaiei oeiii e?ia?; c-i - aaa?oi? c ?acon-eiioe?eoii (c aaiie?oe/iith oai?iaith ieiaea) Oaaeeoey 5 Aeoeai?noue oa?iaio?a (iiieue/oa ia 1 ia a?eea) aioeieneaeaioii? nenoaie ? ai?no SH-a?oi /a?ac 24 aiae i?ney aaaeaiiy Rh-aioeaaia (M+m; n =7-10) Ia’aeoe aeine?aeaeaiiyNIAeEaoaeacaAethoao?ii- ia?ieneaeacaSH-a?oie 0 aiae 24 aiae 0 aiae 24 aiae 0 aiae 24 aiae 0 aiae.24 aiae Nieaiioeeoe39,23 +2,36116,38 +23,41*44,01 +3,7349,16 +57,606,07 +0,437,32 +0,845,31 +0,472,43 +0,30*Iae?ioaae36,03 +2,74109,36 +17,32*66,74 +4,0857,60 +7,138,32 +0,478,24 +0,743,84 +0,282,51 +0,32*E?ia45,22 +3,8922,99 +3,16*46,32 +3,0446,62 +4,198,91 +0,526,26 +0,71*10,27 +0,8521,14 +2,68** p < 0,05 a?aeiinii cia/aiiy aei ?ioi?caoe?? (ioeueiaa aiaeeia) aioeo?e. I?aia?aoii aeai?o noaa aeoeaiee iaoaaie?o a?oai?ia D3 - eaeueoe?o??ie, yeee i?iyaey? ?ioiiiiaeoethth/? aeanoeaino?. A?aeooiaooth/enue a?ae inoaiiueiai, ie aaaaeaee ca aeioe?eueia c eiai aeiiiiiaith ?iaeoeoaaoe i?aeneeaiiy ?ioiii? a?aeiia?ae? o aeiii??a aeey io?eiaiiy ne?iaaoee c aenieei oeo?ii aioe?acon-aioeo?e, yea iaiao?aeia aeey aeaioiaeaiiy niaoeeo?/iiai aioe Rh0(D)-?ioiiaeiaoe?io. Aoei i?iaaaeaii aea/aiiy aieeao a?oai?ia D ia aoii?aeueio ?ioiio a?aeiia?aeue o aenia?eiaioaeueieo oaa?ei ia ??ci? aioeaaie ia ??ai? aioeo?eii?iaeoeoth/eo ee?oei (AIE) ? ni?iaaoeiaeo aioeo?e. Aenia?eiaioaeuei? aeine?aeaeaiiy aoee i?iaaaeai? a aeine?aeao ye c iiaeaeueiei aioeaaiii (oa?ii?iaeoeaiaaieie aaeoa??aeueieie ee?oeiaie Staphylococcus aureus, ooai Wood 46), oae ? c Rh-iiceoeaieie a?eo?ioeeoaie aeiii??a 0(I) a?oie e?ia?. Aeai? uiaei aieeao a?oai?io D ia e?euee?noue aioeo?eiooai?thth/eo ee?oei a naeac?ioe? ? oeo?e ne?iaaoeiaeo aioeo?e i?ney ?ioi?caoe?? oaa?ei noao?eieieii i?aaenoaaeai? a oaae. 6. sse aeieeaa? c i?aaenoaaeaieo ?acoeueoao?a, e?euee?noue aioeo?eiooai?thth/eo ee?oei a naeac?ioe? oaa?ei, ui iaea?aeoaaee a?oai?i D, o 7 ?ac?a aeua, i?ae o eiio?ieueieo oaa?ei, yeei aaiaeeee o?eueee noao?eieieiaee aioeaai ( p < 0,001). Aeey oiai, uia ioe?ieoe caeaoi?noue a?oai?io D aieeaaoe ia ?icaeoie ?ioiii? a?aeiia?ae? ia o?eueee ia aaeoa??aeuei? aioeaaie, aea e ia neioac aioeo?e, niaoeeo?/ieo aei Rh(+)-aioeaaio, aoei i?iaaaeaii aenia?eiaioe c aeniaaeaiiy ne?iaaoie ieoae ?acon-iaaaoeaieie a?eo?ioeeoaie, ui i?ecaiaeeei aei nooo?aiai cieaeaiiy oeo??a aioeo?e, ye? iai?aaeai? i?ioe ?acon-iiceoeaieo a?eo?ioeeo?a, ? iiaii? a?aenooiino? aioeo?e aei ?acon-iaaaoeaieo a?eo?ioeeo?a. Oaaeeoey 6 Aieea a?oai?io D ia oeo?e aioeo?e a ne?iaaooe? e?ia? ? e?euee?noue aioeo?eiooai?thth/eo ee?oei a naeac?ioe? aeine?aeieo oaa?ei A?oie oaa?eiE?euee?noue AOE ia naeac?ieoAaee/eia oeo??a AOM+mtp- log2t?Eiio?ieue (?ioi?caoe?y o?eueee noao?eieieii)2280 +25-- 3,5 +0,3--Aeine?ae (?ioi?caoe?y noao?eieieii+a?oai?i D)15510 +74317,81<0,001 5,5 +0,354,35<0,001 Oaeei /eiii, io?eiai? aeai? na?ae/aoue, ui a?oai?i D o aeacaieo aeicao caeaoiee iineethaaoe aoii?aeueio ?ioiio a?aeiia?aeue aeine?aeieo oaa?ei aei ?acon-aioeaaio. I?iaaaeai? aeine?aeaeaiiy aeicaieythoue c?iaeoe aeniiaie uiaei ia?niaeoeaiino? canoinoaaiiy a?oai?io D ye ?ioiinoeioeyoi?a aeey i?aeneeaiiy e?ioeaaeo aoai?a aoii?aeueii? ?ioiii? a?aeiia?ae?, a naia - i?iaeoeoe?? aioeaainiaoeeo?/ieo aioeo?e. Oea iiaea aooe canoiniaaii c iaoith i?aeaeuaiiy oeo??a aioe?acon-aioeo?e o aeiii??a-i?iaeooeaio?a aeey aeaioiaeaiiy aioe?acon-?ioiiaeiaoe?io ethaeeie. I?aeaeuaiiy oeo??a niaoeeo?/ieo aioeo?e a i?aia?ao? aioe?acon-?ioiiaeiaoe?io ? iioei?caoe?y noai eiai canoinoaaiiy ni?eyoeia aoaeoeai?e i?io?eaeoeoe? ?acon-nainea?e?caoe?? ? cieaeaiith ia?eiaoaeueieo nia?oiino? e caoai?thaaiino? a?ae aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai. O ?ac? eiee, eiee aioeaai iio?aiey? a i?aai?ci, a iueiio oi?iothoueny ?aaeoe?? ee?oeiiiai oa aoii?aeueiiai oeio, ni?yiiaai? ia ae?i?iaoe?th /oaei??aeiiai iaoa??aeo (A.I.Naaeueia, 1993). Ii/aoeii ia?aaoaeiae ?ioiii? nenoaie ? aeoeaaoe?y a?eueii?aaeeeaeueieo i?ioean?a a i?aai?ci? (TH.I.Eiaeaaieeia, 1985). A ?acoeueoao? oi?io?oueny oe?e?nia a?aeiia?aeia ?aaeoe?y ia ao?o/aiiy aioeaaio, ui aeeth/a? ia o?eueee eaiee ?ioi?oaoo, aea e ?io? aiiainoaoe/i? iaoai?cie. A?ae oiai, ye? ?ioiieiiiaoaioi? ee?oeie aoaeooue caeo/ai? aei a?aeiia?ae?, caeaaeaoeia ?? oi?ia. A?aeiii, ui i?iaeoeoe a?eueii?aaeeeaeueiiai ieeneaiiy aeathoue neaiae aei aeoeaaoe?? ?ioiieiiiaoaioieo ee?oei ? ii/aoeo ?ioiii? a?aeiia?ae? (A.A.Ecaaeiaa, 1991). Io?eiai? o ?cinainea?e?ciaaieo aaa?oieo aeai? na?ae/aoue i?i cia/iee ia?a?iciiae?e ?ioiieiiiaoaioieo ee?oei, ye? aeeiiothoue ??ci? ooieoe??, ? i?e ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? oa?aeoa?ecothoue iai?oaeaiiy nenoaiiiai ?ioi?oaoo (oaae. 7). Ne?ae cacia/eoe, ui /ei a?eueoa o?aaeaiee ie?ae, oiaoi /ei aaae/ee nooi?iue AO, oei ae?aci?o? oe? ci?ie. Anoaiiaeai? iaie iae?ioi?iaoeai?o? iieacieee ?ioiiiai noaoono iaoa??, ui a?aeia?aaeathoue nooi?iue ?ioiii? aa?an?? iaoa?? ii a?aeioaiith aei ieiaea, iiaeooue aooe aeei?enoai? ye ae?aaiinoe/i? oa i?iaiinoe/i? e?eoa??? a ioe?ioe? oyaeeino? ?ioiieia?/iiai eiioe?eoo. Oaaeeoey 7 ?ioaineai?noue ?ioiieia?/ieo iieaciee?a o ?cinainea?e?ciaaieo aaa?oieo a caeaaeiino? a?ae ia?eiaoaeueiiai ?acoeueoaoa i?e AO (M+m) A?oiaE?eue-e?noue ianoa-aeaieoIE, %E, %Aoo/-?OE?AOE ia OAA, %?AOE ia OAA+ i?aaei?-cieii, %Na?aaei?e % ?aaeoe?? ia i?aae-i?cieiiNoaee?i?/ia oi?ia AO2619,84 +1,059,0 +1,3314,80 +0,7360,0 +1,029,58 +1,20*50,70Eaaeee nooi?iue AO2823,73 +0,9865,21+ 1,49*12,87 +0,81*63,80 +1,1041,33 +1,16*35,22Na?aaei?e nooi?iue AO2425,32 +1,2*68,18 +1,38*10,61 +0,65*70,20 +1,20*52,63 +1,10*25,03Oyaeeee nooi?iue AO2128,15 +1,3*71,10 +1,47*6,80 +0,27*77,50 +1,43*61,11 +0,94*21,15Aioaiaoaeue-ia caaeaaeue ieiaea1931,27 +1,18*73,52 +1,51*5,96 +0,38*79,58 +1,19*63,0 +1,08* 20,84Eiio?ieue (Rh-iaaaoea-i? aaa?oi? aac Rh-aioeo?e) 54 20,52 +1,21 60,70 +1,34 15,60 +0,89 62,20 +0,65 32,86 +1,04 47,17 * A??ia?aei? a?aei?iiino? iieaciee?a ii??aiyii c eiio?ieai (p < 0,05). Aeey c’ynoaaiiy iayaiino? ei?aeyoe?eieo ca’yce?a i?ae aea/aieie iieacieeaie, ui oa?aeoa?ecothoue noai a?eueii?aaeeeaeueieo i?ioean?a, ? neeaaeii ?ioiieiiiaoaioeo ee?oei o ianoaaeaieo aaa?oieo aoa i?iaaaeaiee ei?aeyoe?eiee aiae?c, yeee iieacaa, ui c ?icaeoeii ?acon-eiioe?eoo ci?iththoueny oa?aeoa? ? neea ca’yce?a i?ae e?euee?noth ?ioiieiiiaoaioieo ee?oei oa ?ioaineai?noth ieenithaaeueii-a?aeiiaieo i?ioean?a. I?ae ??aiyie a?ao?aeiiiai? eeneioe oa i?iaeoeo?a ?? iaoaaie?/iiai ieeniaiiy anoaiiaeai? ??cii? neee iiceoeai? ca’ycee, ye?, eiia??ii, na?ae/aoue i?i aeeiai?/iee i?ioean ?? ooai?aiiy, ui iino?eii ci?ith?oueny, yeee i?aeoaa?aeaeo? iaiao?aei?noue ?o aecia/aiiy aeey oa?aeoa?enoeee aoaeue-yeiai noaio a aeeiai?oe?. Neeueiee iiceoeaiee ca’ycie anoaiiaeaii i?ae ??aiai o?e?iiaeo eii’thaao?a oa e?euee?noth E-ee?oei, yeee, iaaii, iiaeia ?icoe?ithaaoe ye i?aeaeuaiiy aioeo?eicaeaaeii? ee?oeiii? oeeoioiene/iino? i?e iaeiie/aii? o?e?iiaeo eii’thaao?a. Oea iiaea aooe aeei?enoaia i?e aeeiai?/iiio niinoa?aaeaii? c iaoith ioe?iee ia?aa?ao ?acon-eiioe?eoii? aaa?oiino? oa ?? i?iaiico. Oaeei /eiii, io?eiai? aeai? na?ae/aoue i?i oa, ui ?icaeoie ?acon-eiioe?eoii? aaa?oiino? ci?ith? ?ioaineai?noue ia?aeeniiai ieeniaiiy e?i?ae?a oa a?eueii?aaeeeaeueiiai ieeniaiiy a i?aai?ci? iaoa??, ui noi?iaiaeaeo?oueny ci?iith neeaaeo ?ioiieiiiaoaieo ee?oei c ??cieie ?ioiieie ooieoe?yie. Oa?aeoa? ? aeeaeia aeyaeaieo a?aeoeeaiue caeaaeaoue a?ae nooiaiy oyaeeino? aaiie?oe/ii? oai?iae ieiaea. Aea/ai? iieacieee iiaeooue aooe aeei?enoai? c ae?aaiinoe/iith ? i?iaiinoe/iith iaoith aeey ioe?iee oyaeeino? ?acon-eiioe?eoo ? a?aoiaai? i?e aeai?? aaeaeaaoii? ?ioiieia?/ii? oa iaoaaie?/ii? ei?aeoe??. Ia iniia? io?eiaieo aeaieo i?i noai ?ioiieia?/ii? ?aaeoeaiino?, ?ioaineaiino? IIE ? ??aiy i?iaeoeo?a a?eueii?aaeeeaeueiiai ieeniaiiy e?i?ae?a ie i?iaaee aeine?aeaeaiiy aoaeoeaiino? e?eoaaeueieo caoiae?a a caeaaeiino? a?ae ae?aciino? aeacaieo i?ioean?a. Aiae?c canoinoaaiiy ieaciaoa?aco o aaa?oieo c ?acon-nainea?e?caoe??th iieacaa, ui iaoiae aeioe?eueiee i?e iayaiino? aenieiai oeo?o i?ioe?aconieo aioeo?e, aeinoaoiuei aenieiio ??ai? i?iaeoeoea a?eueii?aaeeeaeueiiai ieeniaiiy e?i?ae?a, cieaeaiiio ??ai? aioeieneaeaio?a e?ia? ia oii? iii??ii? aeoeaaoe?? ?ioiii? nenoaie. Aecia/aii, ui iaaaeee? ianyae aenooc?? ieacie, ui i?iaiaeeeeny c iaaaeeeeie i?ii?aeeaie, ni?eythoue no?eeiio cieaeaiith oeo?o i?ioe?aconieo aioeo?e. ?iia??ii, oea iiynith?oueny oei, ui o a?aeiia?aeue ia aeeo/aiiy iaaaeeei? e?eueeino? ieacie ?ioiia nenoaia iaoa?? ia ni?aoeueiao? eiiiainaoi?iei aeeeaeii iiaeo aioeo?e. ?icaeoie aaiie?oe/ii? oai?iae ieiaea iiaeia ?icaeyaeaoe ye no?aniao ?aaeoe?th i?aai?cio, yea noi?iaiaeaeo?oueny aeoeaaoe??th a?eueii?aaeeeaeueiiai ieeneaiiy, iia??oaiiyi ?aieia?/ieo aeanoeainoae e?ia? ? i?e?ioee?eoeyoe??, ?icaeoeii a?iien??, ii?ooaiiyi aiaeii-aeaeo?ie?oiiai ? aoaeaaiaeiiai iai?i?a ia o?eueee iaoa?einueeiai, aea e ieiaeiaiai i?aai?cio. A oeeo oiiaao canoinoaaiiy oa?iaeieia?/ieo cania?a, ye? i?eai?/othoue i?ioeane ia?aeeniiai ieeniaiiy e?i?ae?a ? iie?auothoue i?e?ioee?eoeyoe?th, iaoiaaiaoe/ii iaa?oioiaaii. C oe??th iaoith aoea aea/aia eiia?iiaaia ae?y a?oai?io A ? o?aioaeo o aaa?oieo c ?acon-nainea?e?caoe??th. A?oai?i A i?ecia/aee aioo??oiueii’yciai o aeaeyae? 10 %-ai ianeyiiai ?ic/eio ii 100 ia aea?/? ia aeiao. O?aioae aaiaeeany aioo??oiueiaaiii ii 0,1 a, yeee aeiaeaaaee o 250-500 ie 5,0 % ?ic/eio aetheice /a?ac aeaiue. Io?eiai? aeai? na?ae/aoue, ui i?iaaaeaiiy eiia?iiaaii? oa?ai?? ni?ey? iie?ioaiith iaoaaie?/iiai noaio iaoa?einueeiai i?aai?cio, ia ui aeaco? cieaeaiiy ?ioaineaiino? IIE o ianoaaeaiiai eiioeiaaioo aaa?oieo. Oea iiceoeaii a?aeaeaa?oueny ia noai? aioo??oiueioo?iaiiai ieiaea. A?aoiaoth/e aeai? e?oa?aoo?e i?i iiceoeaiee aieea nieai?io ia a?aeiiaeaiiy /ooeeaino? O-e?ioioeeo?a aei aetheiei?oeei?ae?a, ie aaaaeaee ca iaiao?aeia c’ynoaaoe, /e ii?aeio?oueny ae?y oeueiai i?aia?aoo c iiceoeaiei aieeaii eiai ia ?ioiiee noaoon aaa?oieo c ?acon-nainea?e?caoe??th. Aeey oeueiai iaie aoee ianoaaeai? 25 aaa?oieo c ?acon-eiioe?eoii a o? ae oa?i?ie aaa?oiino?, yeei iaeii/anii c i?aaei?cieiiii i?ecia/aany nieai?i ii 2 ie o?e/? ia aeaiue i?ioyaii 2 oeaei?a. Noia?i? aeai? noiniaii noaio ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo o aaa?oieo c ?acon-nainea?e?caoe??th aei oa i?ney e?eoaaiiy ?ioiiiiaeoethth/eie i?aia?aoaie iaaaaeai? a oaae. 8. Oaaeeoey 8 Noai ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo o aaa?oieo c ?acon- nainea?e?caoe??th aei oa i?ney e?eoaaiiy ?ioiiiiaeoethth/eie i?aia?aoaie ?ioiieia?/iee iieacieeIa??iae e?eoaaiiyEiio?ieue (n=10)I?aaei?cieii (n=23)I?aaei?cieii+ nieai?i (n=25)12345A-?OEAei43,9 + 1.244,2 + 1,3 42,6 + 1,2I?ney41,8 + 1,034,4 + 0,9* ** 38,3 + 1,1* **?AOE ia OAAAei72,3 + 0,973,5 + 0,7 70,9 + 1,0I?ney70,1 + 0,866,8 +1,0* ** 65,4 + 0,9* **AAN-?OE, %Aei24,4 + 0,723,9 + 0,9 23,7 + 0,7I?ney25,2 + 0.821,3 + 0,8* ** 19,0 + 0,8* **Ig G, a/eAei12,3 + 0,412,9 + 0,3 11,0 + 0,4I?ney13,0 + 0,510,8 + 0,5* ** 9,3 + 0,3* **Ig I, a/eAei1,26 + 0,21,29 + 0,41,32 + 0,1I?ney1,18 + 0,31,32 + 0,61,20 + 0,2Ig A, a/eAei1,79 + 0,41,85 + 0,31,92 + 0,3I?ney1,52 + 0,31,39 + 0,2* ** 1,59 + 0,2* **A-?OEoo/Aei 8,3 +1,08,10 + 0,9 8,1 + 0,5I?ney 7,8 + 0,95,60 + 0,7**11,8 + 0,6* **A-?OEoonAei 33,5 + 1,2033,2 + 1,333,0 + 0,6I?ney34,0 + 1,036,6 + 1,1* ** 36,0 + 0,7**???Aei 4,0 + 0,9 4,0 + 0,74,07 + 0,4I?ney 4,4 + 1,0 6,3 + 0,8** 2,81 + 0,5**?AOE ia OAAAei51,2 + 1,150,95 + 1,254,6 + 0,9+ i?aaei?cieiiI?ney50,0 + 1,051,20 + 1,030,4 + 1,0% cieaeaiiyAei29,1 30,623,0I?ney28,7 23,453,5 * A??ia?aei?noue a?aei?iiinoae ii??aiyii c eiio?ieai. ** A??ia?aei?noue a?aei?iiinoae i?ae iieacieeaie aei ? i?ney e?eoaaiiy. sse na?ae/aoue io?eiai? ?acoeueoaoe, i?ecia/aiiy i?aaei?cieiio ? nieai?io aeeeeea? iaai? ci?ie ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo. I?e eiia?iiaaiiio i?eeii? oeeo ?ioiiiiaeoeyoi??a cieaeothoueny e?euee?noue oa ooieoe?iiaeueia aeoeai?noue O-e?ioioeeo?a, aaee/eie yeeo iaaeeaeathoueny aei iieaciee?a, ui oa?aeoa?ecothoue o?c?ieia?/iee ia?aa?a aaa?oiino?. Iaeii/ania eiia?iiaaia aeei?enoaiiy i?aaei?cieiio ? nieai?io cieaeo? e?euee?noue e ooieoe?iiaeueio aeoeai?noue A-e?ioioeeo?a, iiceoeaiei i?iyaii /iai ? ciaioaiiy ??aiy aioeo?e. Ua iaeiei iiceoeaiei oaeoi?ii ? oa, ui i?e eiia?iiaaiiio i?eeii? aeacaieo ?ioiiiiaeoeyoi??a ca?eueoo?oueny e?euee?noue O-ee?oei c noi?ani?iith ooieoe??th, ui oa?aeoa?eco? o?c?ieia?/iee ia?aa?a aaa?oiino?. I?e oaeiio ia?a?iciiae?e? noaiiioeyoe?eiiai neeaaeo O-e?ioioeeo?a cia/ii ciaioo?oueny ?ioii?aaoeyoi?iee ?iaeaen (???), aaee/eia yeiai aeinyaa? 2,81+0,5. sse na?ae/aoue aeai? oaae. 8, iaeaieiai?oei aoaeoii iiceoeaiiai aieeao eiia?iiaaii? ae?? ?ioiiiiaeoeyoi??a ? cia/ia i?aeaeuaiiy /ooeeaino? O-e?ioioeeo?a aei aetheiei?oeei?ae?a. Oae, a?aenioie cieaeaiiy ?aaeoe?? ia i?oiaai a i?enooiino? i?aaei?cieiio in vitro i?ney e?eoaaiiy noaiiaea 53,5. Na?aae aaa?oieo c ?acon-nainea?e?caoe??th, ye? io?eioaaee i?aaei?cieii c nieai?iii, cieaeaiiy oeo?o aioe?acon-aioeo?e ia 2-3 ii?yaeee a?aei?/aia o 12 (49 %), ia 1-2 ii?yaeee o 10 (43 %), ? o?eueee o 3 aaa?oieo ia aoei ca?a?no?iaaia cieaeaiiy oeo?o aioeo?e. Aeeoa?aioe?eiaaiee i?aeo?ae aei i?ecia/aiiy eiiieaenii? ?ioiiei?eaoth/i? ? aioeieneaeaioii? oa?ai?? o aaa?oieo c ?acon-nainea?e?caoe??th ni?ey? cieaeaiith ?icaeoeo aaaeeeo oi?i aaiie?oe/ii? oai?iae ? iie?ioo? ia?eiaoaeuei? iane?aeee. AENIIAEE 1. Ee?i?ei-noaoenoenoe/iee aiae?c iieacaa, ui ?acon-nainea?e?caoe?y ?icaeaa?oueny o 12,5-13,1 %, a ?acon-eiioe?eo - o 4,1-4,5 % ?acon-iaaaoeaieo aaa?oieo. O ae?iie c ?cinainea?e?ciaaiith aaa?oi?noth, yea oa?aeoa?ecoaaeany ?icaeoeii ?acon-eiioe?eoo, noaee?i?/ia oi?ia aaiie?oe/ii? oai?iae ieiaea aecia/aeany o 12,5 %, eaaeee nooi?iue - o 26,0, na?aaei?e - 23,5, oyaeeee - 16,0 % aeiaaee?a. Aioaiaoaeueia caaeaaeue ieiaea aoea o 22,0 % ae?iie. A?aoiaoth/e a?aenioie inoaiiuei? a?ae AOI ? ??aaiue oyaeeeo o?aaeaiue ieiaea, /anoea ?icaeoeo aaaeeeo oi?i AO aeineoue aeniea. 2. I?e ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? a i?aai?ci? iaoa?? a?aeaoaathoueny nooo?a? ci?ie noaio ?ioiieia?/ii? ?aaeoeaiino?, ye? ae?aaeathoueny a i?aeaeuaii? e?eueeino? oa ooieoe?iiaeueii? aeoeaiino? O-, A-e?ioioeeo?a oa nooo?aiio cieaeaii? e?eueeino? O-ee?oei ?c noi?ani?ieie ooieoe?yie, ui cia/ii i?aeaeuo? ?ioii?aaoeyoi?iee ?iaeaen. Ii?yae c oeei a?aecia/a?oueny ae?acia cieaeaiiy /ooeeaino? e?ioioeeo?a aei aetheiei?oeei?ae?a. ?icaeoie ?acon-eiioe?eoo noi?iaiaeaeo?oueny /?oeith aeeiai?eith i?aeaeuaiiy i?e?iaeii? oa aioeo?eicaeaaeii? ee?oeiii? oeeoioiene/iino?, ae?aciei i?aeaeuaiiyi ooieoe?iiaeueii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a. 3. Aecia/aiiy HLA-oaiioeio aeicaiey? aeae?eeoe a?oio ?eceeo aaa?oieo a?aeiinii ?icaeoeo oyaeeeo oi?i AOI aeey caaacia/aiiy caoiae?a uiaei ?aiiuei? ae?aaiinoeee ? ni?yiiaaii? i?io?eaeoeee aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai.Aaiaoe/ieie ia?ea?aie noeeueiino? aei ?icaeoeo AOI ? HLA-aioeaaie eieono A: A2; A9; A3; eieono A: A7; A17 ? A14 o iaoa??a. Aenieee ?ecee ?aae?caoe?? ?acon-eiioe?eoii? neooaoe?? iathoue ae?iee c A(II) a?oiith e?ia?. Iaoyaeoth/ei aaiaoe/iei oaeoi?ii ? noi?ni?noue ca a?oiith e?ia? o iiae?oaei?e ia??. Noeeuei?noue aei ?icaeoeo oyaeeeo oi?i AOI anioe?eiaaia c? niieo/aiiyi aioeaai?a HLA A9 A14 i?e ?o iaeii/ani?e iaeaaeiino? ? o iaoa??, ? o aaoueea. 4. ?aae?caoe?y ?acon-eiioe?eoii? neooaoe?? noi?iaiaeaeo?oueny ?icaeoeii iaia?aiii? iaoieia?? a on?o eaieao nenoaie iaoe-ieaoeaioa-ie?ae, ui ae?aaea?oueny o iineeaii? a?eueii?aaeeeaeueieo i?ioean?a e IIE. ?ioaineai?noue IIE ? a?eueii?aaeeeaeueiiai ieeniaiiy ei?aeth? c? neeaaeii ? e?euee?noth ?ioiieiiiaoaioieo ee?oei a i?aai?ci? iaoa??. Oa?aeoa? ? neea ca’yce?a ci?iththoueny c ?icaeoeii ?acon-eiioe?eoo; ?o aeeaeia caeaaeeoue a?ae nooiaiy oyaeeino? AOI. Oea i?aee?aneth? iaiao?aei?noue aacia?a?aiiai iii?oi?eiao ?acon-nainea?e?ciaaieo aaa?oieo c iaoith ioe?iee ia?aa?ao ?acon-eiioe?eoo. 5. Anoaiiaeaia ?ioi?iaoeaia cia/ou?noue ?ioiieia?/ieo ? a?io?i?/ieo iieaciee?a aeey i?iaiicoaaiiy ? ae?aaiinoeee ?aii?o i?iya?a aaiie?oe/ii? oai?iae. Iaea?eueo i?iaiinoe/ii cia/oueie ?: cieaeaiiy e?eueeino? O-e?ioioeeo?a c noi?ani?ieie ooieoe?yie, i?eai?/aiiy /ooeeaino? e?ioioeeo?a aei aetheiei?oeei?ae?a, iaeii/ania i?aeaeuaiiy i?e?iaeii? oa aioeo?eicaeaaeii? ee?oeiii? oeeoioiene/iino?, oa?aeoa? eeneioieo a?eo?ia?ai (aenioa iniiaiiai oieey, ii/aoeiaee /an aaiie?co) ? a?ioai?ethi?i?noeaioe?? e?ia? aaa?oieo (na?oeinoia na?o?iiy oa ?ioaineai?noue na?o?iiy), ?iaeaen a?aeiioaiiy ??aiy anei?aaocaeaaeiiai aei IAAeO-caeaaeiiai e?iiia?aieeniaiiy. 7. ?ic?iaeaia iaoaiaoe/ia iiaeaeue, yea ca noeoii?noth ia?aiao??a ia?aeeniiai ieeniaiiy e?i?ae?a aeicaiey? ioe?ieoe iaaaciaeo ?icaeoeo aaiie?oe/ii? oai?iae ieiaea. 8. Aecia/ai? iaoai?cie ?ioiii? a?aeiia?ae? ia ?acon-aioeaai. Anoaiiaeaii, ui a?ineioaco aioe?acon-aioeo?e (IgG) ia?aaeo? aeoeaaoe?y ?ioiii? nenoaie. Inoaiiy cae?enith?oueny a ?ioiieiiiaoaioieo ee?oeiao a oiio /ene? e ca ?aooiie aeoeaaoe?? oinoie?i?aeii? neaiaeueii? nenoaie. Iaeiei c ?aaoeyoi??a ?icaeoeo ?ioiii? ?aaeoe?? ? ?ic/eiia aoai?eaooeeeeaca, yea ca’ycaia c oinoie?i?aeiith neaiaeueiith nenoaiith /a?ac i?iaeoeoe a?eueii?aaeeeaeueiiai ieeniaiiy a?ao?aeiiiai? eeneioe - eaeeio???ie ? i?inoaaeaiae?ie, a oaeiae a?euei? ?aaeeeaee - I2-, NO, OH, ui i?iaeoeothoueny aeoeaiaaieie iae?ioaaaie ii e?i?aeiiio ? ioeeaioeaeiiio eaiaeo e eiio?ieththoueny aioeieneaeaioiith nenoaiith. Aenioo aoii?aeueii? a?aeiia?ae? ia ?acon-aioeaai a i?ioean? ?? aaia?ae?caoe?? iiaeia iiaeoethaaoe a caeaaeiino? a?ae aaaeaieo ?acoeueoao?a: iineaaeoe o aeiaaeeo aeanainea?e?caoe?? i?e aaa?oiino?, i?aeneeeoe - i?e a?ia??ioi?caoe?? aeiii??a. 9. A aenia?eiaio? anoaiiaeaii, ui canoinoaaiiy eaeueoeeo??ieo ye ?ioiinoeioeyoi?a i?eaiaeeoue aei i?aeaeuaiiy oeo?o aioe?acon-aioeo?e o ?acon-?ioi?ciaaieo oaa?ei, ui iiaea aooe aeei?enoaii aeey i?aeneeaiiy ?ioiii? a?aeiia?ae? o aeiii??a i?e io?eiaii? ne?iaaoee c aenieei oeo?ii aioe?acon-aioeo?e. I?aeaeuaiiy niaoeeo?/ieo aeanoeainoae aoe?acon-?ioiiaeiaoe?io ni?eyoeia ca?eueoaiith aoaeoeaiino? niaoeeo?/ii? ?ioiii?io?eaeoeee ?acon-nainea?e?caoe?? o aaa?oieo. 10. Anoaiiaeaii, ui ?icaeoie oyaeeeo oi?i aaiie?oe/ii? oai?iae ieiaea ? iiaiia?iaeaeaiiai coiiaeaiee aeniaaeaiiyi aaeaioaoe?eii-eiiiainaoi?ieo iaoai?ci?a o nenoai? iaoe-ieaoeaioa-ie?ae. Aeey iie?auaiiy ooieoe?iiaeueii? iiaiioe?iiino? oaoiieaoeaioa?iiai eiiieaeno i?e aaiie?oe/i?e oai?ia? c iaoith iie?ioaiiy ia?eiaoaeueieo iane?aee?a iaiao?aeii canoiniaoaaoe naeaeoeaio ?ioiio ? iaoaaie?/io ei?aeoe?th noaio aaa?oii?. 11. Cai?iiiiiaaii iioeiaeuei? i?ia?aie ei?aeoe?? ?ioiieia?/ieo ? iaoaaie?/ieo cnoa?a o aaa?oieo c ?cinainea?e?caoe??th aeey cieaeaiiy ?acon-nainea?e?caoe??. I?ia?aie a?aoiaothoue aeo?aeiee ??aaiue aeyaeaieo ci?i ? aeeth/athoue ieaciaoa?ac, ?ioiiiiaeoethth/o oa aioeieneaeaioio oa?ai?th. 12. Iii?oi?eia ca iieacieeaie, ye? oa?aeoa?ecothoue ?ioiieia?/iee oa iaoaaie?/iee i?io?eue, a oaeiae aeeoa?aioe?eiaaiee i?aeo?ae aei aaaeaiiy aaa?oieo c ?acon-nainea?e?caoe??th i?aeaeuothoue aoaeoeai?noue i?io?eaeoe/ieo oa e?eoaaeueieo caoiae?a, cieaeothoue ia?eiaoaeueio nia?oi?noue a?ae aaiie?oe/ii? oai?iae o 1,5 ?ace. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey cieaeaiiy a?ia??ioi?caoe?? o iaoa?? oa iiia?aaeaeaiiy aaaeeeo oi?i aaiie?oe/ii? oai?iae ?aeiiaiaeiaaii i?ecia/aiiy ia?a?ea/anoiai ieaciaoa?aco, yeee ia o?eueee cieaeo? nooi?iue nainea?e?caoe??, aea e ni?ey? i?aeneeaiith aeoeaiino? aioeieneaeaio?a e?ia? ? cieaeaiith ??aiy i?iaeoeo?a a?eueii?aaeeeaeueiiai ieeniaiiy e?i?ae?a. 2. Aeey caaacia/aiiy a?iinainea?e?coth/iai aoaeoo ? ei?aeoe?? ?ioiieia?/iiai noaio aaa?oieo c ?acon-eiioe?eoii ?aeiiaiaeiaaii eiia?iiaaia aeei?enoaiiy i?aaei?cieiio oa nieai?io. I?aeaeuaiiy aoaeoeaiino? e?eoaaiiy noa?i?aeieie ai?iiiaie aeinyaa?oueny a?aeiiaeaiiyi /ooeeaino? e?ioioeeo?a aei aetheiei?oeei?ae?a ca ?aooiie iiceoeaii? ae?? nieai?io. Caaaeyee eiia?iiaaiiio aeei?enoaiith ?ioiiiiaeoeyoi??a aeinyaa?oueny a?eueo cia/iee aoaeo e?eoaaiiy, ciaioothoueny /an ? aeice aeei?enoaiiy noa?i?aeieo ai?iii?a. 3. Aeey iie?ioaiiy ooieoe?iiaeueii? iiaiioe?iiino? oaoiieaoeaioa?iiai eiiieaeno aoaeoeaia noeoiia canoinoaaiiy a?oai?io A ? o?aioaeo. 4. Aeey naeaeoeaii? ei?aeoe?? iaoaaie?/ieo ii?ooaiue o aaa?oieo c ?acon-nainea?e?caoe??th ?aeiiaiaeiaaii aeeoa?aioe?eiaaia i?ecia/aiiy a?oai?io A e anaioe?aea. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Ninoiyiea eeaoi/iiai e aoii?aeueiiai eiioieoaoa o aa?aiaiiuo n iaauiaoeaaieai ia oiia eiioeeeoa ii ?acon-oaeoi?o // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.-1982.-? 4.- N.37-39 (Niaao. Iaeaoeia ?.E., A?oaiiiia A.N., Aoeiiaaiiaa A.I., Eiioa A., A?iiiaa E.Ae.). 2. Anoanoaaiiua eeaoee-eeeea?u i?e aa?aiaiiinoe, ineiaeiaiiie ?acon-eiioeeeoii // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.-Ee?a; Eoaainuee, 1996.-Aei. 5.- N.39-45. 3. Neeaae ?ioiieiiiaoaioieo ee?oei o aaa?oieo c ?acon-nainea?e?caoe??th // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.-Ee?a; Eoaainuee, 1997.-Aei. 2.- N.25-29. 4. Aioeoaeicaaeneiay oeeoioiene/iinoue eeioioeeoia ia?eoa?e/aneie e?iae i?e aa?aiaiiinoe, ineiaeiaiiie ?acon-eiioeeeoii // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue. - Ee?a; Eoaainuee, 1997.-Aei. 5.- N.59-64. 5. Eiioiieiae/aneea acaeiiioiioaiey iaoa?e e ieiaea i?e oeceieiae/aneie e ineiaeiaiiie ?acon-eiioeeeoii aa?aiaiiinoe // Aanoi. i?iaeai aeieiaee e iaaeeoeeiu.-1997.-? 10.- N. 25-40. 6. Aea/aiiy HLA aioeaai?a o aaa?oieo c ?acon-nainea?e?caoe??th // Iaae. ia?niaeoeae.-1997.-O. 2, ? 2.- N.48-51. 7. ?ioiieiiiaoaioi? ee?oeie i?e ?acon-eiioe?eoi?e aaa?oiino? // Iaae. ia?niaeoeae.-1997.-O. 2, ? 3.- N.43-45. 8. Iniaaiiinoe i?ioeannia ia?aeeniiai ieeneaiey eeieaeia o aa?aiaiiuo n ?acon-naineaeeecaoeeae a caaeneiinoe io niiniaa ?iaei?ac?aoaiey // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.-Ee?a; Eoaainuee, 1998.-Aei. 3.- N.123-129 (Ni?aaao. Caaei??ia I.A.). 9. Ooieoe?iiaeueia aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a i?e ?acon-eiioe?eoi?e aaa?oiino? // Iaae. ia?niaeoeae.-1998.-O. 3, ? 1.- N. 54-56. 10. E?eoaaeueiee ieaciaoa?ac o eiiieaeni?e oa?ai?? aaa?oieo c ?ci?ioi?caoe??th ca ?acon-oaeoi?ii // Oe?. iaoe.-iaaee/i. iieiae?aei. aeo?i.-1998.-? 1.- N.90-93 (Ni?aaao. Ionoia?o ss.A.). 11. Noai ia?aeeniiai ieeneaiiy e?i?ae?a o aaa?oieo ae?iie c ?acon-nainea?e?caoe??th // Oe?. iaoe.-iaaee/i. iieiae?aei. aeo?i.-1998.-? 2-3. -N.102-105 (Ni?aaao. Ionoia?o ss.A., Caaei??ia I.A.). 12. Eiia?iiaaia canoinoaaiiy a?oai?ia A oa o?aioaeo a e?eoaaii? aaa?oieo c ?acon-nainea?e?caoe??th // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.-Ee?a; Eoaainuee, 1998.-Aei. 1(15).- N.119-125. 13. Aeine?aeaeaiiy eeneioii? no?eeino? a?eo?ioeeo?a i?e ?acon-eiioe?eoi?e aaa?oiino? // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.-Ee?a; Eoaainuee, 1998.-Aei. 5(19).- N.102-111 (Ni?aaao. A.A.Eioeth?oaa, I.I.Aooaiaae/). 14. Iniaeeaino? ?iciiae?eo HLA-aioeaai?a o ?acon-nainea?e?ciaaieo aaa?oieo // A?ni. i?iaeai a?ieia?? oa iaaeeoeeie.-1999. - ? 5.- N.38-41. 15. Canoinoaaiiy ?ioiiiiaeoethth/eo i?aia?ao?a aeey e?eoaaiiy aaa?oieo c ?acon-nainea?e?caoe??th // E?ee.-1999.-? 1.- N.7-11. 16. Aieea a?oai?io D ia aoii?aeueio ?ioiio a?aeiia?aeue ieoae aei ?acon-aioeaaio // Iaae. ia?niaeoeae.-1999.-O. 4, ? 1.- N.12-14. 17. I?e?iaeia oa aioeo?eicaeaaeia oeeoioiene/i?noue e?ioioeeo?a ia?eoa?e/ii? e?ia? i?e oneeaaeiaiee ?acon-eiioe?eoii aaa?oiino? // Iaae. ia?niaeoeae. - 1999.-O. 4, ? 1.- N. 60-63. 18. A?eueii?aaeeeaeuei? i?ioeane oa neeaae ?ioiieiiiaoaioieo ee?oei o aaa?oieo c ?acon-nainea?e?caoe??th // Oe?.iaoe.-iaaee/i. iieiae?aei. aeo?i.-1999.-? 1/2.- N.74-6 (Ni?aaao. Ionoia?o ss.A., A?oaiiiia A.N., Na?aethoeueea E.O.). 19. Naiaiaeii?aaeeeaeueiua i?ioeannu i?e oeceieiae/aneie e ineiaeiaiiie ?acon-eiioeeeoii aa?aiaiiinoe // A?ni. i?iaeai a?ieia?? oa iaaeeoeeie.-1999. - ? 4.- N.3-8. 20. Aeeyiea aaee/eiu oaoiiaoa?eineie o?ainoocee ia eiioiiue noaoon aa?aiaiiuo n ecinaineaeeecaoeeae // A?ni. i?iaeai a?ieia?? oa iaaeeoeeie. - 1999.-? 5.- N.7-10. 21. Nia?aiaiiua naaaeaiey i i?ioeeaeoeea e ea/aiee aaiieeoe/aneie aieacie ieiaea e iiai?iaeaeaiiiai i?e ?acon-eiioeeeoa // A?ni. i?iaeai a?ieia?? oa iaaeeoeeie.-1999.-? 11.- N.7-14. 22. Iaa?oiooaaiiy aioeieneaeaioii? oa?ai?? i?e ?acon-eiioe?eoi?e aaa?oiino? // A?ni. i?iaeai a?ieia?? oa iaaeeoeeie.-1999.-? 12.- N.3-7. 23. Nenoaia HLA i?e ?acon-eiioe?eoi?e aaa?oiino? // I?iaeaie aeieia?? oa iaaeeoeeie.-1999.-? 1-2.- N.71-78. 24. ?ioiieia?/i? aniaeoe iaaeiiooaaiiy i?e ?acon-ianoi?niino? // I?iaeaie aeieia?? oa iaaeeoeeie.-1999.-? 1-2.- N.86-93. 25. Aieea ?acon-aioeaaio ia Na++-/ooeeao oinoie?i?aecaeaaeio neaiaeueio nenoaio ee?oei ?ioiii? nenoaie // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: ca. iaoe. i?aoeue.- Ee?a; Eoaainuee, 1999.-Aei. 2(22).- N.54- 60 (Ni?aaao. A?oaiiiia A.N., Eioeth?oaa A.A., Aooaiaae/ I.I.). 26. 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International Symposium: Abstracts.- Kiev, 1996.-p. 110 (Co-author Artamonov V.S.). 44. Aeoea?caoe?y ?ioiii? a?aeiia?ae? ia ?acon-aioeaai a aenia?eiaio? // ? Iaoe?iiaeueiee eiia?an Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??: oace aeii. –Aeoooa, 1996.- n.166. Aiaoei I.I. “?ioiia?io?i?/i? aniaeoe ae?aaiinoeee, e?eoaaiiy, i?io?eaeoeee ?acon-eiioe?eoii? aaa?oiino? oa aaiie?oe/ii? oai?iae ieiaea oa iiaiia?iaeaeaiiai”.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01- aeooa?noai oa a?iaeieia?y.- Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.aeaae. I.I.Aiaiiieueoey, Oe?a?ia, Ee?a, 1999 ?iaioa i?enay/aia aeine?aeaeaiith iaoai?ci?a ?aae?caoe?? niaaeeiai? noeeueiino?, c’ynoaaiith ?ie? ?ioiieia?/ii? ?aaeoeaiino? oa iaoaaie?/ieo ci?i a i?aai?ci? iaoa?? a iaoiaaiac? ?acon-eiioe?eoo. Anoaiiaeaii ia?ea?e niaaeeiai? noeeueiino? aei ?aae?caoe?? ?acon-eiioe?eoo ye o iaoa??a, oae ? a iiae?oaei?e ia??. ?acon-eiioe?eo noi?iaiaeaeo?oueny ci?iaie iiioeyoe?eiiai ? noaiiioeyoe?eiiai neeaaeo, a oaeiae ooieoe?iiaeueii? aeoeaiino? ?ioiieiiiaoaioieo ee?oei, ?ioaineo?eaoe??th i?ioean?a IIE ? a?eueii?aaeeeaeueiiai ieeneaiiy a on?o eaieao nenoaie iaoeieaoeaioaie?ae. Ae?aci?noue ci?i ?ioiieia?/ieo ? iaoaaie?/ieo iieaciee?a caeaaeeoue a?ae nooiaiy oyaeeino? aaiie?oe/ii? oai?iae. Anoaiiaeaii ae?aaiinoe/i? ? i?iaiinoe/i? e?eoa??? ?icaeoeo aaaeeeo oi?i aaiie?oe/ii? oai?iae. Iaa?oioiaaii i?aeoiaee oa iioeiaeuei? i?ia?aie e?eoaaeueii-i?io?eaeoe/ieo caoiae?a c aeeth/aiiyi naeaeoeaii? ?ioiii? ? iaoaaie?/ii? ei?aeoe?? ci?i aiiainoaco iaoa?einueeiai i?aai?cio c iaoith iie?ioaiiy ia?eiaoaeueieo ?acoeueoao?a. Eeth/ia? neiaa: Aaa?oi?noue, ?acon-eiioe?eo, aaiie?oe/ia oai?iaa ieiaea ? iiaiia?iaeaeaiiai, HLA-nenoaia, ?ioiia nenoaia, ia?aeenia ieeniaiiy e?i?ae?a, a?eueii?aaeeeaeueia ieeniaiiy, iaoiaaiaoe/ia oa?ai?y Aiaoei A.I. Eioiiaeioeie/aneea aniaeou aeeaaiinoeee, ea/aiey, i?ioeeaeoeee ?acon-eiioeeeoiie aa?aiaiinoe e aaiioiee/aneie aieacie ieiaea e iiai?iaeae?iiiai.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/?iie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 – “aeooa?noai e aeiaeieiaey”.- Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. Aeaae. A.A.Aiaiiieueoea, Oe?aeia, Eeaa, 1999 Enneaaeiaaiu iaoaieciu ?aaeecaoeee ianeaaenoaaiiie i?aae?aniieiaeaiiinoe, eiio?iee?oaiie nenoaiie HLA, auyniaia ?ieue eiioiieiae/aneie ?aaeoeaiinoe e iaoaaiee/aneeo eciaiaiee a i?aaiecia iaoa?e a iaoiaaiaca ?acon-eiioeeeoa. Ianeaaeiaaii 309 aeaiuei ?ai?iaeoeoeaiiai aic?anoa, ec eioi?uo 289 iiaoi?iiaa?aiaiiuo a aeeiaieea aa?aiaiiinoe. Ia?ea?aie ianeaaenoaaiiie i?aae?aniieiaeaiiinoe yaeeenue HLA-aioeaaiu eieona A: A2; A9; A3; eieona A: A14, A35, A40 o iaoa?ae. Aunieee ?ene ?aaeecaoeee ?acon-eiioeeeoiie neooaoeee eiatho aeaiueiu ni A(II) a?oiiie e?iae. Onoaoaeythuei oaeoi?ii yaeyaony niaianoeiinoue ii a?oiia e?iae a noi?oaeaneie ia?a, ni/aoaiea aioeaaiia HLA A9 A14 i?e eo iaeiia?aiaiiie i?eiaaeeaaeiinoe o iaoa?e e iooea, iaee/ea o ieo iaueo HLA-aioeaaiia. Eiioiieiae/aneia enneaaeiaaiea i?e ?acon-eiioeeeoa onoaiiaeei eciaiaiey ninoaaa e ooieoeeiiaeueiie aeoeaiinoe O- e A-eeioioeeoia, oiaiueoaiea eiee/anoaa O-noi?anni?ia, oaaee/aiea eiioii?aaoeyoi?iiai eiaeaena, nieaeaiea /oanoaeoaeueiinoe eeioioeeoia e aetheiei?oeeieaeai, iaeiia?aiaiiia iiauoaiea anoanoaaiiie e aioeoaeicaaeneiie eeaoi/iie oeeoioiene/iinoe. ?aaeecaoeey ?acon-eiioeeeoiie neooaoeee nii?iaiaeaeaaony ?acaeoeai iaia?aiiie iaoieiaee ai anao caaiueyo nenoaiu iaoueieaoeaioaieiae: eioaineoeeaoeeae i?ioeannia IIE e naiaiaeii?aaeeeaeueiiai ieeneaiey. Auyaeaiu acaeiinayce iaaeaeo eioaineaiinoueth IIE e eiioiieiae/aneeie iieacaoaeyie, iaiythueany a caaeneiinoe io oyaeanoe aaiieeoe/aneie aieacie. A yenia?eiaioa onoaiiaeaiu iaaeeaoi?iua iaoaieciu aaia?aeecaoeee eiioiiiai ioaaoa ia ?acon-aioeaai. Onoaiiaeaiu aeeaaiinoe/aneea e i?iaiinoe/aneea e?eoa?ee ?acaeoey oyaeaeuo oi?i aaiieeoe/aneie aieacie, aeeth/athuea eiee/anoai O-noi?anni?ia, /oanoaeoaeueiinue eeioioeeoia e aetheiei?oeeieaeai, anoanoaaiioth e aioeoaeicaaeneioth eeaoi/ioth oeeoioiene/iinoue, oa?aeoa? e?eauo eeneioiuo y?eo?ia?aii e aeioaieethieienoeaioeee e?iae aa?aiaiiuo. Iainiiaaiu iiaeoiaeu e i?aaeeiaeaiu iioeiaeueiua i?ia?aiiu ei??aeoeee eiioiieiae/aneeo e iaoaaiee/aneeo naeaeaia o aa?aiaiiuo aeey nieaeaiey ?acon-naineaeeecaoeee, aeeth/athuea ieaciaoa?ac, eiioiiiiaeoee?othuoth e aioeieneaeaioioth oa?aieth. Iiaeoaa?aeaeaiu iaiaoiaeeiinoue i?iaaaeaiey iiieoi?eiaa ca iieacaoaeyie eiioiiaeioeie/aneiai aiiainoaca, aeeooa?ai-oee?iaaiiue iiaeoiae e aaaeaieth aa?aiaiiuo, /oi iiauoaao yooaeoeaiinoue i?ioeeaeoe/aneeo e ea/aaiuo ia?ii?eyoee, nieaeaao ia?eiaoaeueioth nia?oiinoue io aaiieeoe/aneie aieacie. Eeth/aaua neiaa: Aa?aiaiiinoue, ?acon-eiioeeeo, aaiieeoe/aneay aieaciue ieiaea e iiai?iaeaeaiiiai, HLA-nenoaia, eiioiiay nenoaia, ia?aeeniia ieeneaiea eeieaeia, naiaiaeii?aaeeeaeueiia ieeneaiea, iaoiaaiaoe/aneay oa?aiey. Gnatko E.P. “The immunobiochemical aspects ofdiagnostics, treatment? Prjphylaxis of rhesus-coflict pregnancy and hemolytic disease of fetus and newborn”.-Manuscript. The dissertation for doctors degree in medicine? Specialty 14.01/01- obstetrics and gynecology.-National medical university named after acad A.A.Bogomolets, Ukraine, Kyiv, 1999. The work is devoted to the investigation of mechanisms of realization of hereditary pre disposition, elucidation of the role of immunological reactivity and metabolic changes in maternal organism in rhesus-conflict’s pathogenesis. The markers of hereditary pre disposition for rhesus-conflict’s realization in mothers as well as in matrimonial couples established. Rhesus-conflict pregnancy is accompanied by changes in population and subpopulation contents and functional activity of immunocompetent cells, by intensification of processes of lipid’s peroxide oxidation in all links of the system mother - placenta - fetus. The expressiveness of changes in immunological and metabolic indices depends on the degree of hemolytic disease dangerous. The diagnostic and prognostic criteria of dangerous forms of hemolytic disease’s development established. The approaches and optimum programmes of medicinal-prophylactic measures with inclusion the selective immune and metabolic correction of maternal organism’s homeostasis with purpose to improve the perinatal results were grounded. Key word: ?regnancy, rhesus-conflict, hemolytic disease of fetus and newborn, HLA-system, immune system, peroxide oxidation of lipids, free-radical oxidation, pathogenetic therapy

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