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Характеристика темпу старіння у хворих на паркінсонізм по показникам біологічного віку: Автореф. дис… канд. мед. наук / Г.В. Мусієнко, Київ. мед. ак

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I?i?noa?noai Ioi?iie Caei?iay Oe?a?ie

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe

?i.I.E.Ooieea

Ion??iei Aaeeia A?eoi??aia

OAeE 616.858-008.6-08-053.9

Oa?aeoa?enoeea oaiio noa??iiy

o oai?eo ia ia?e?inii?ci

ii iieacieeai a?ieia?/iiai a?eo.

14.01.15 – ia?aia? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien?iaioa aeeiiaia a ?inoeooo?aa?iioieia?? AII
Oe?a?ie.Iaoeiaee ea??aiee:aeieoi? iaaee/ieo iaoe Iiethoia Ieaenaiae?
Ieoaeeiae/; ?inoeooo aa?iioieia?? AII Oe?a?ie, a?aeae?e ee?i?/ii?
o?c?ieia?? oa iaoieia?? ia?aiai? nenoaie, caa?aeoaa/ a?aeae?eo.Io?oe?ei?
iiiiaioe:aeieoi? iaaee/ieo iaoe, i?ioani? Naiinthe ?aai Caoa?iae/;
Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC
Oe?a?ie, eaoaae?a iaaee/ii? ?aaa?e?oaoe??, o?c?ioa?ai?? oa eo?i?oieia??,
caa?aeoaa/ eaoaae?e.aeieoi? iaaee/ieo iaoe, i?ioani? Eenaithe A?eoi?
Iaaeiae/; Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey,
eaoaae?a ?aaa?e?oaoe?eii? iaaeeoeeie, caa?aeoaa/ eaoaae?e.I?ia?aeia
onoaiiaa: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ee?i?/ii? oa
aenia?eiaioaeueii? iaa?ieia?? ? ineo?ao??? IIC Oe?a?ie, a?aeae?e
noaeeiii? iaoieia?? aieiaiiai iiceo, i. Oa?e?a.

Caoeno a?aeaoaeaoueny ” 27 ” aeiaoiy 1999 ?. i 10-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.613.01 i?e Ee?anuee?e
iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea I?i?noa?noaa
Ioi?iie Caei?iay Oe?a?ie (254112, i. Ee?a, aoe. Aei?iaiaeeoeueea, 9,
aoaeeoi??y ?3)

C aeena?oaoe??th iiaeia iciaeiieoenue o iaoeia?e a?ae?ioaoe? Ee?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie
(254112, i.Ee?a, aoe. Aei?iaiaeeoeueea,9)

Aaoi?aoa?ao ?ic?neaiee “ 26 ” aa?aniy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

e.i.i., aeioeaio____________________________________________?iiaiaiei
I.?.

Aeooaeuei?noue oaie. A?aeiii, ui ia?e?inii?ci – oea o?ii?/ia
i?ia?anoth/a iae?iaeaaaia?aoeaia caoai?thaaiiy oeaio?aeueii? ia?aiai?
nenoaie, oaeoi?ii ?eceeo ?icaeoeo yeiai ? a?eiaa aeno?ai??ai?aeia
iaaeinoaoi?noue [Ea?aaaiue ?.I.,1990].

A aenia?eiaio? oa ee?i?oe? iieacaii no?oeoo?ii-ooieoe?iiaeueio ?aei?noue
cnoa?a, ui aeieeathoue i?e ia?e?inii?ci? oa noa??ii? ia an?o ??aiyo
oeaio?aeueii? ia?aiai? nenoaie, ii/eiath/e c ei?eiaeo a?aeae?e?a,
no?oeoo? i?a?i-no??i-iae?aea?ii? nenoaie aei noaieiai-ni?iaeueieo
aia?ao?a. I?e noa??ii? oa ia?e?inii?ci? ci?ie ooieoe?iiaeueiiai noaio
oeaio?aeueii? ia?aiai? nenoaie ye?nii aiaeia?/i?, aea cia/ii
a?ae??ciythoueny ii ?ioaineaiino?, ui aea? i?aenoaao eiinoaooaaoe ?o
iaeiiiai?aaeai?noue, a oaeiae ?icaeyaeaoe ia?e?inii?ci ye iaeei c
aa??aio?a i?enei?aiiai noa??iiy Hornykievicz O. 1988, Rinne et al.,
1989, Finch, 1990, Sawle et al., 1990, De Keyser et al., 1990,
A.I.E?uaeaiianeee e niaao., 1995.

Iaeiei c i?aeoiae?a aeey ??oaiiy oeueiai ieoaiiy ? aeei?enoaiiy iaoiaeo
e?euee?nii? ioe?iee oaiio noa??iiy ca aeiiiiiaith iieaciee?a
a?ieia?/iiai (ooieoe?iiaeueiiai) a?eo (AA). Iaoiaeieia?y oeeo
aeine?aeaeaiue aeineoue aeieeaaeii ?ic?iaeyeanue ia i?ioyc? inoaii?o
15-20 ?ie?a a ?inoeooo? aa?iioieia?? AII Oe?a?ie [Aieoaiei A.I. e
niaao., 1984, Ei?eooei I.A. e niaao., 1989, Iiethoia A.I. e niaao.,
1992]. E?euee?nia ioe?iea nooiai? ?icaeoeo a?eiaeo ci?i o oai?eo ia
ia?e?inii?ci iiaeeeaa oeyoii aeei?enoaiiy iieaciee?a AA ye e?eoa??th
ooieoe?iiaeueiiai noaio oeaio?aeueii? ia?aiai? nenoaie ? i?aai?cio
acaaae?. AA iiaea aooe i??ith ioe?iee nenoaiii? aeac?ioaa?aoe??
i?aai?cio [A.I.Iiethoia e niaao., 1996].

Noa??iiy ethaeeie, a a?eueoino? aeiaaee?a, a?aeaoaa?oueny ii
iaoieia?/iiio, i?enei?aiiio oeio, oiaoi /anoioa neiae?ii?a i?enei?aiiai
noa??iiy c?inoa? [I.A.Ei?eooei, 1990, I.A.Ei?eooei e niaao., 1996]. I?e
i?enei?aiiio noa??ii? a i?aai?ci? aeieeathoue oiiae aeey ?icaeoeo
caoai?thaaiue, ye? iia’ycai? c a?eii, ? ye?, noai?thth/e ii?i/ia eiei,
iiaeooue i?enei?thaaoe oaii noa??iiy.

*eneaii? aenia?eiaioaeuei? oa ee?i?/i? aeine?aeaeaiiy iai?aaeai? ia
iiooe oae caaieo aa?ii?ioaeoi??a – ?a/iaei, ui ca?eueoothoue o?eaae?noue
aeeooy, oiia?eueiththoue i?ioeane noa??iiy oa ia?aoeiaeaeathoue yaeuai
i?enei?aiiai noa??iiy [J.Scardigli, 1988, E.I.Yiaioaeue, 1982,
A.A.O?ieueeen, O.E.Io?aaeyi, 1988]. Anoaiiaeaii, ui o in?a c i?enei?aiei
noa??iiyi i?aia?ao o?iae?i, ui noaiiaeoue niaith aeoyaeeo c o?iono
aaeeei? ?iaaoi? ooaeiae ? a?aeiineoueny aei a?oie oeeoiiaae?i?a,
ii?iae?co? iai?ii? i?ioeane, ooieoe?iiaeueiee noai ??cieo nenoai
i?aai?cio, ui, ii?yae ?c cieaeaiiyi iieaciee?a ia?oe?aeueiiai
ooieoe?iiaeueiiai a?eo ? na?aeioeoaii eiai aa?ii?ioaeoi?ii? ae??
[Ii?icia A.A. e niaao., 1978, 1983, Nio?iiia e niaao., 1984, Aieneiia
A.I., 1987, Cae/aiei e niaao., 1994, Ei?eooei I.A. e niaao., 1996]. Ana
cacia/aia aeicaiey? i?eionoeoe iiceoeaiee e?eoaaeueiee aoaeo o?iae?io a
eiiieaeni?e iaoiaaiaoe/i?e oa?ai?? oai?eo ia ia?e?inii?ci.

A e?oa?aoo?? oe?iei aeeneooo?oueny ieoaiiy i?i aeioe?euei?noue
aeei?enoaiiy e?ea?nueeeo i?aia?ao?a, ye? iathoue iae?ii?ioaeoi?iee
aoaeo. Aei oaeeo i?aia?ao?a a?aeiinyoue aaii?no aeioai?io – ia?eiaeae.
Iioaioe?eiee iae?ii?ioaeoi?iee aoaeo oeueiai i?aia?aoo cae?enith?oueny
ca ?aooiie aeoeaoth/i? ae?? ia aeioai?ia?a?/io o?aini?n?th, ii?ooaiiy
yei? aaaaeathoue aaaeo/ei eaioethaii a iaoiaaiac? ia?e?inii?cio
[Yoshikawa T .e.a., 1994; Mizuno Y. e.a., 1995; Poewe W., Caraceni T.
1995]. Oe? aeai? aeyaeeenue iaa?oiooaaiiyi aea/aiiy iae?ii?ioaeoi?iiai
aoaeoo ia?eiaeaeo i?e i?ecia/aii? eiai oai?ei ia ia?e?inii?ci ia oe?
aacenii? i?ioeia?e?inii?/ii? oa?ai??.

A e?oa?aoo?? oe?iei iiaeai? aeaii? ii iaoiaaiaco, ee?i?oe? oa oa?ai??
ia?e?inii?cio. ?acii c oei, a?aenooi? ni?iae ioe?iee oaiio noa??iiy
oaeeo oai?eo ca aeiiiiiaith ?ioaa?aeueieo oa?aeoa?enoee a?ieia?/iiai
a?eo oa ?o caeaaeiino? a?ae o?eaaeino? caoai?thaaiiy ? eaeaiaea?iiai
a?eo. I?aeoe/ii ia aea/aia iiaeeea?noue ei?aeoe?? ii?ooaieo ooieoe?e ca
aeiiiiiaith aeei?enoaiiy aa?i- ? iae?ii?ioaeoi?ieo i?aia?ao?a o
eiiieaeni?e iaoiaaiaoe/i?e oa?ai?? ia?e?inii?cio.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiioaaeanue o A?aeae?e? ee?i?/ii? o?c?ieia?? oa iaoieia?? ia?aiai?
nenoaie ?inoeoooo aa?iioieia?? AII Oe?a?ie o a?aeiia?aeiino? c ieaiii
iaoeiai-aeine?aeieo ?ia?o ca oaiaie: “Ee?i?ei-o?c?ieia?/ia
oa?aeoa?enoeea i?enei?aiiai noa??iiy” (?2253, 1992-1996 ?.), ui ?
o?aaiaioii aea?aeaaii? iaoeiai-i?aeoe/ii? i?ia?aie ?1.06.02/014-92
“I?enei?aia noa??iiy: i?e/eie, iaoai?cie, i?io?eaeoeea”; “?ic?iaea oa
ioe?iea aieeao aa?ii?ioaeoi?ieo cania?a ia ooieoe?iiaeueiee noai iiceo
i?e a?e-caeaaei?e oea?aa?aeuei?e iaoieia??” (?005.95, 1995-1997 ?.) oa
“Ee?i?ei-ae?aaiinoe/i? aniaeoe, iaoai?cie ?icaeoeo oa iaaeeeaiaioicia
oa?ai?y ia?e?inii?cio” (?310, 1992-1994 ?.).

Iaoa ?iaioe: i?iaanoe ioe?ieo oaiio noa??iiy o oai?eo ia ia?e?inii?ci
na?aaeiueiai ? iioeeiai a?eo iaoiaeii aecia/aiiy iieaciee?a a?ieia?/iiai
a?eo oa ioe?ieoe ?ieue ie?aieo iae?ii?ioaeoi?ieo ? aa?ii?ioaeoi?ieo
i?aia?ao?a a eiiieaeni?e oa?ai?? caoai?thaaiiy.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe oaii noa??iiy o oai?eo ia ia?e?inii?ci na?aaeiueiai ?
iioeeiai a?eo ca aeiiiiiaith ??cieo iiaeaeae a?ieia?/iiai a?eo.

2. I?iaanoe ioe?ieo iieaciee?a AA a caeaaeiino? a?ae eaeaiaea?iiai a?eo
oa o?eaaeino? caoai?thaaiiy o oai?eo ia ia?e?inii?ci.

3. I?iaiae?coaaoe ie?ai? iieacieee, ye? aoiaeyoue aei aaoa?a? oano?a
aeey aecia/aiiy AA, o oai?eo ia ia?e?inii?ci a ii??aiyii? c
iiioeyoe?eiei eiio?ieai.

4. Ioe?ieoe aoaeoeai?noue o?iae?io ? ia?eiaeaeo a eiiieaeni?e oa?ai??
oai?eo ia ia?e?inii?ci.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aea/aii oaii noa??iiy
oa iniaeeaino? ooieoe?iiaeueiiai noaio oeaio?aeueii? ia?aiai? nenoaie o
oai?eo ia ia?e?inii?ci iaoiaeii ioe?iee iieaciee?a a?ieia?/iiai a?eo,
aecia/aii ?o ca’ycie c eaeaiaea?iei a?eii oai?eo ? o?eaae?noth
caoai?thaaiiy. Aia?oa aecia/aia ?ieue ii?aeiaiiai aeei?enoaiiy aa?i- ?
iae?ii?ioaeoi??a c aacenieie aioeia?e?inii?/ieie i?aia?aoaie, aeaia
ee?i?ei-o?c?ieia?/ia ioe?iea aoaeoeaiino? o?iae?io ? ia?eiaeaeo a
eiiieaeni?e iaoiaaiaoe/i?e oa?ai?? ia?e?inii?cio.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe i?iaaaeaieo
aeine?aeaeaiue iiaeooue aeei?enoiaoaaoenue aeey ioe?iee
ooieoe?iiaeueiiai noaio oeaio?aeueii? ia?aiai? nenoaie o oai?eo ia
ia?e?inii?ci. Iienai? a ?iaio? iaoiaeeee iiaeooue aeei?enoiaoaaoenue
aeey ia?eoeaii? ioe?iee aoaeoeaiino? i?aia?ao?a o oai?eo ia ia?e?inii?ci
a eiiieaeni?e oa?ai?? caoai?thaaiiy. Anoaiiaeaia a?aeiia?aeii
aa?ii?ioaeoi?ia oa iae?ii?ioaeoi?ia aoaeoeai?noue o?iae?io oa ia?eiaeaeo
a eiiieaeni?e iaoiaaiaoe/i?e oa?ai?? ia?e?inii?cio aea? iiaeeea?noue
?aeiiaiaeoaaoe oe? i?aia?aoe aeey aeeth/aiiy a noaie e?eoaaiiy aeaieo
oai?eo.

Io?eiai? ?acoeueoaoe aeei?enoiaothoueny i?e /eoaii? eaeoe?e ia eaoaae??
aa?iioieia?? oa aa??ao??? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe ?i.I.E.Ooieea IIC Oe?a?ie. ?acoeueoaoe ?iaioe cai?iaaaeaeaii a
ee?i?/io i?aeoeeo o a?aeae?eaii? aia?iiaa?ieia?? Aieiaiiai a?enueeiaiai
ee?i?/iiai aini?oaeth, i?i ui na?ae/aoue aeoe ai?iaaaeaeaiiy.

Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a a io?eiai? ?acoeueoaoe ?
iniiaiei ? iieyaa? o ?ic?iaoe? iaoiaee/iiai i?aeoiaeo, iinoaiiaoe? iaoe
oa oi?ioethaaii? caaaeaiue aeine?aeaeaiiy. Aaoi?o iaeaaeeoue aanue ianya
?iaioe, iia’ycaii? c ianoaaeaiiyi oai?eo, c aiae?cii, /eneiaith oa
eiii’thoa?iith ia?iaeith io?eiaieo aenia?eiaioaeueieo aeaieo,
iaaiai?aiiyi ?acoeueoao?a aeine?aeaeaiue, i?aeaioiaeith iaoeiaeo
iaoa??ae?a aei ioae?eaoe?e.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? ?acoeueoaoe aeine?aeaeaiue
aeiiia?aeaeenue ia can?aeaiiyo A/aii? ?aaee A?aeae?eo ee?i?/ii?
aa?iioieia?? ? aa??ao??? ?inoeoooo aa?iioieia?? AII Oe?a?i?, ia ?
Iaoe?iiaeueiiio C?cae? aa?iioieia?a Oe?a?ie (Ee?a, 1994), ia ?
Iaoe?iiaeueiiio Eiia?an? iaa?iiaoieia?a, ineo?ao??a ? ia?eieia?a Oe?a?i?
(Oa?e?a, 1996).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 6 iaoeiaeo i?aoeue, c
ieo: 2 – iniaenoi, 4 – o ni?aaaoi?noa?; a oiio /ene?: 4 – o iaoeiaeo
aeo?iaeao, 2 – o iaoa??aeao a?o/eciyieo oa ca?oa?aeieo eiia?an?a.

No?oeoo?a ? ia’?i aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 173 noi??ieao
iaoeiiieniiai oaenoo ? neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, iieno
iaoiae?a ianoaaeaiue, aeaio ?icae?e?a ?acoeueoao?a aeanieo
aeine?aeaeaiue, i?aenoie?a oa aeniiae?a. Nienie aeei?enoaieo
e?oa?aoo?ieo aeaea?ae ia?aoiao? 131 a?o/eciyieo ? 100 ca?oa?aeieo ?ia?o.

Iniiaiee ci?no ?iaioe.

Iaoa??aee ? iaoiaee aeine?aeaeaiue. Ee?i?ei-iae?io?c?ieia?/i? ?
iae?i-ooieoe?iiaeuei? ianoaaeaiiy aoee i?iaaaeai? o 83 oai?eo ia oai?iao
Ia?e?iniia (?ae?iiaoe/iee ia?e?inii?ci) na?aaeiueiai ? iioeeiai a?eo
(45-59 ?ie?a ? 60-74 ?iee) c iciaeaie caoai?thaaiiy, ui a?aeiia?aeathoue
?A-??A nooiaith ae?aciino? [I.A.Iaiueeianueeee e niaao.,1982],
aai1,5-2,5 noaae?? ca I?aeia?iaeiith oeaeith Unifed Parkinsons Disease
Rating Scale (UPDRS) [Hoehn M., Yahr M., 1967 – aa?n?y 1987 ?ieo].
Oaeiae, 15 oai?eo ianoaaeaii aei ? i?ney e?eoaaiiy o?iae?iii, 21 oai?ee
ianoaaeaiee aei ? i?ney e?eoaaiiy ia?eiaeaeii, eiio?ieueio a?oio
noaiiaeee 15 oai?eo, ye? ia iaea?aeoaaee e?eoaaiiy oeeie i?aia?aoaie.

A aeai?e ?iaio? canoiniaaii eiiieaenio i?ia?aio ianoaaeaiiy, ui
aeeth/aea ee?i?/io ioe?ieo ? ia?aiao?e, ye? oa?aeoa?ecoaaee
ooieoe?iiaeueiee noai oeaio?aeueii? ia?aiai? nenoaie, na?oeaai-noaeeiii?
nenoaie, aeeoaeueii? nenoaie ? i?aai?cio a oe?eiio.

Ee?i?/ia ianoaaeaiiy neeaaeaeiny c iaeyaeo oa eaai?aoi?iiai
aeine?aeaeaiiy iaoe??ioa (caaaeueiee aiae?c e?ia?, caaaeueiee aiae?c
na/?, AEA, aiae?c e?ia? ia ai?no aetheice, ?AA, AAA, AIA).

Aecia/aeenue iieacieee AA ca ?ioaa?aeueiith ? ia?oe?aeueieie iiaeaeyie –
ea?ae?i-ioeueiiiaeueiith, iae?i-ooieoe?iiaeueiith oa ineoieia?/iith.
?iaeea?aeoaeuei? iieacieee a?ieia?/iiai a?eo ?ic?aoiaoaaeenue ca
aeiiiiiaith oi?ioe iiiaeeiii? e?i?eii? ?aa?an??, aea caeaaeiith ci?iiith
aoa eaeaiaea?iee a?e (EA) aeaiiai oai?iai, iacaeaaeieie ci?iieie –
ia?aiao?e, ye? oa?aeoa?ecothoue a?aeiia?aei? ooieoe?iiaeuei? nenoaie
i?aai?cio, oa aeniei ei?aeththoue c EA (ia?ea?e noa??iiy). Eiao?oe??ioe
?aa?an?? aoei iaea?aeaii ia iniia? aeine?aeaeaiiy iiioeyoe?eii? aea??ee.
?ioaa?aeuei? iieacieee AA aoee ae?aaeai? a ?ieao ? ii??aithaaeeny c
iieacieeii iaeaaeiiai a?ieia?/iiai a?eo (IAA), ui noaiiaeoue niaith
na?aaei? iiioeyoe?ei? cia/aiiy AA aeey a?aeiia?aeiiai EA (iiioeyoe?eiee
noaiaea?o).

IAA aecia/aany ca oi?ioeith:

IAA = (EA?iae. – EAna?aaei.) o R2 + EAna?aaei.,

aea: EA?iae. oa EAna?aaei. a?aeiia?aeii – a?e ?iaeea?aeooia ? na?aaei?e
a?e an?o aeine?aeaeaieo a iiioeyoe?ei?e aea??oe?, ca yeith aoea
?ic?aoiaaia oi?ioea AA, R – eiao?oe??io iiiaeeiii? ei?aeyoe?? i?ae EA ?
aaoa?a?th oano?a [A.I.Aieoaiei, A.I.Iiethoia, 1984].

?a?no?aoe?th a?iiioaioe?ae?a aieiaiiai iiceo i?iaiaeeee iiiiiiey?iei
niiniaii ca caaaeueiii?eeiyoeie noaiaea?oaie a?ae 10 a?aeaaaeaiue:
eiaieo (F3-F4), oeaio?aeueieo (C3-C4), o?iyieo (P3-P4), ne?iiaaeo
(O3-O4) oa iioeee/ieo (O1-O2). Aiae?coaaeenue a?ae??cee AAA o?eaae?noth
a 100 naeoiae, ye? ia i?noeee a?oaoaeo?a. Aeey aaaaeaiiy ? ia?iaee
aioeaoaeia?ai aeei?enoiaoaaee oi?aa?naeueio eiiithoa?io nenoaio IA-
Iae?iea?oia?ao (IAI, Iineaa, 1994). Aecia/aee ia?aiao?e oaeeue a
ianooiieo /anoioieo ae?aiaciiao (Aoe): aeaeueoa (0-4,0), oaoa1
(4,1-6,0), oaoa2 (6,1-8,0), aeueoa (8,1-13,0) oa aaoa1(13,1-20,0).

Noaoenoe/iee aiae?c aeeth/aa aeei?enoaiiy iaia?aiao?e/ieo e?eoa???a
(e?eoa??e ciae?a ? e?eoa??e o?-eaae?ao), iaoiae?a aa??aoe?eii?
noaoenoeee (t-e?eoa??e Nothaeaioa, t-e?eoa??e Nothaeaioa aeey
ia?iicaycaieo iciae) oa ei?aeyoe?eiiai aiae?co. ?ic?aooiee i?iaiaeeee ca
noaiaea?oieie i?ia?aiaie (Microsoft Excel).

Iniiai? ?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Na?aae oai?eo ia
ia?e?inii?ci a?aecia/a?oueny oaiaeaioe?y aei ia?aaaaeaiiy iaoe??io?a ?c
cia/aiiyie ?ioaa?aeueiiai a?ieia?/iiai a?eo (?AA), ui ia?aaeuothoue
na?aaei? ii iiioeyoe??. Na?aae /ieia?e?a iaoe??ioe ?c cia/aiiyie ?AA, ui
ia?aaeuoaaee iaeaaei?, neeaaeaee 55,3%, a oie /an, ye ?c cia/aiiyie ?AA
iaioa iaeaaeieo oey oeeo?a aei??aithaaea 44,7%. O ae?iie oe? cia/aiiy
a?aeiia?aeii neeaaeaee 63,9% oa 36,1%. Ine?eueee noaoenoe/ii aaaiii?
a?aei?iiino? i?ae /ieia?eaie oa ae?ieaie ia a?aecia/aeinue, a?oie aoee
ia?aeiai? ii noao?. A ia?aeiai?e a?oi? oe? cia/aiiy a?aeiia?aeii
aei??aithaaee 59,0% ? 41,0% (?0,05).

*anoioa in?a c i?aeaeuaiith a?aeiinii iiioeyoe?eiiai noaiaea?oo
aaee/eiith ea?ae?i-ioeueiiiaeueiiai a?ieia?/iiai a?eo (EIAA) na?aae
/ieia?e?a ia?aaaaeaea oaeo o in?a c? cieaeaiith aaee/eiith EIAA, ?
neeaaeaea a?aeiia?aeii 59,6% oa 40,4%, i?ioa ??cieoey ia nyaa? ??aiy
noaoenoe/ii? aeinoia??iino?. O ae?iie ?iciiae?eaiiy in?a ?c i?aeaeuaiith
aai cieaeaiith a?aeiinii iiioeyoe?eiiai noaiaea?oo aaee/eiith EIAA
aeecueea aei neiao?e/iiai – 47,2% oa 52,8%, ??cieoey noaoenoe/ii ia
aaaiia. A ia’?aeiai?e ii noao? a?oi? e?euee?noue in?a c i?aeaeuaiei EIAA
ia?aaeuoaaea e?euee?noue in?a ?c cieaeaiei EIAA ? neeaaeaea a?aeiia?aeii
54,2% oa 45,8%, iaeiae, ye ? a ?icae?eaieo ii noao? aea??eao, ??cieoey
ia nyaa? ??aiy noaoenoe/ii? aeinoia??iino?.

Cia/aiiy iieaciee?a EIAA o ianoaaeaieo iaie oai?eo ia ia?e?inii?ci
nooo?ai caieaeai? /a?ac oa, ui a aea??eo oai?eo ia ia?e?inii?ci ia
aeeth/aeenue iniae c a?oa??aeueiith a?ia?oaic??th aai a?ia?oii?/iith
oai?iaith, ui oneeaaeieei a aeeoa?aioe?eiee ae?aaiic oai?iae Ia?e?iniia
? noaeeiiiai ia?e?inii?cio. I?e ii??aiyii? iieaciee?a, ui aea/athoueny,
o oai?eo ia ia?e?inii?ci ianoaaeaii? a?oie oa in?a eiio?ieueii? a?oie
aac a?oa??aeueii? a?ia?oaic?? aai a?ia?oii?/ii? oai?iae, o ia?oeo
anoaiiaeaii aeinoia??ia ia?aaeuaiiy iieaciee?a EIAA ye ii na?aaei?i
aaee/eiai, oae ? ii ?o ?iciiae?eaiith.

Ca iaoeie aeaieie, ?iciiae?eaiiy oai?eo ia ia?e?inii?ci ii iieacieeo
iae?i-ooieoe?iiaeueiiai a?ieia?/iiai a?eo (IOAA) aeey /ieia?e?a ? ae?iie
iaei aiaeia?/io oaiaeaioe?th. Oey oaiaeaioe?y i?iyaey?oueny a
ca?eueoaii? e?eueeino? oai?eo ia ia?e?inii?ci, o yeeo cia/aiiy IOAA
ia?aaeuothoue na?aaeiueiiiioeyoe?eiee noaiaea?o. Aeey /ieia?e?a
e?euee?noue ianoaaeaieo c iieacieeii IOAA, ui ia?aaeuo? iiioeyoe?eiee
noaiaea?o, neeaaeaea 61,7%, c iieacieeii IOAA, iaioa iaeaaeieo cia/aiue,
neeaaeaea 38,3%. Aeey ae?iie oe? iieacieee aei??aithaaee a?aeiia?aeii
58,3% oa 41,7%. A ia?aeiai?e ii noao? a?oi? oe? cia/aiiy nyaathoue ??aiy
noaoenoe/ii? aeinoia??iino? ? neeaaeaee 60,2% ? 39,8% a?aeiia?aeii.

Aiae?c /anoioe cono??/a?iino? oai?eo ia ia?e?inii?ci a caeaaeiino? a?ae
iiceoeaieo ? iaaaoeaieo cia/aiue ??cieoe? i?ae ineoieia?/iei a?ieia?/iei
a?eii (IAA) oa eiai iiioeyoe?eiei noaiaea?oii oaeiae ? aeieacii
ca?eueoaiiy iieaciee?a IAA o a?eueoino? ianoaaeaieo. O /ieia?e?a oe?
iieacieee neeaaeaee 66,3% ? 34,0%, o ae?iie – 61,1% ? 38,9%
a?aeiia?aeii. A ia?aeiai?e ii noao? aeai?oe? a?aei?/aii aenieee nooi?iue
ia?aaaae in?a ?c ca?eueoaiiyi cia/aiue ineoieia?/iiai a?ieia?/iiai a?eo
– 63,9% oa 36,1% (p0,01) a?aeiia?aeii.

Oaeei /eiii, aiae?c oa?aeoa?o ?iciiae?eaiiy oai?eo ia ia?e?inii?ci a
caeaaeiino? a?ae i?aeaeuaieo aai cieaeaieo, a ii??aiyii? c
iiioeyoe?eieie noaiaea?oaie, cia/aiue AA ii an?i /ioe?ueii aeei?enoaiei
iiaeaeyi aeyaey? caaaeueio oaiaeaioe?th, yea ? na?aeioeoaii iaaiiai
i?aeaeuaiiy oaiio noa??iiy o a?eueoino? oai?eo ia ia?e?inii?ci.

Na?aaeiy aaee/eia a?aeoeeaiiy iieaciee?a ?iaeea?aeoaeueiiai a?ieia?/iiai
a?eo a?ae iaeaaeieo eiai aaee/ei (iiioeyoe?eiiai noaiaea?oo) ii iiaeae?
?AA na?ae/eoue i?i ia?aaeuaiiy oeueiai iieacieea a a?oi? oai?eo ia
ia?e?inii?ci o /ieia?e?a – ia 3,01,3 ?iee (p0,05), o ae?iie – ia 4,62,0
?iee (p0,05), a ia?aeiai?e ii noao? aea??oe? – ia 3,71,0 ?iee (p0,01).

Oaei? /?oei? oaiaeaioe?? ia a?aecia/a?oueny o a?aeiioaii?
ea?ae?i-ioeueiiiaeueiiai AA. O /ieia?e?a EIAA ia?aaeuo? AeEIAA ia 2,71,6
?iee (p0,05), o ae?iie iieaciee EIAA iaioa iaeaaeiiai cia/aiiy ia 1,41,6
?iee (p0,05). A ia?aeiai?e ii noao? aea??oe? EIAA ia?aaeuo? IEIAA ia
0,91,1 ?iee (p0,05). Iaeiae, i?e ii??aiyii? c iieacieeaie EIAA o in?a
eiio?ieueii? a?oie (aac a?oa??aeueii? a?ia?oaic??) a?aecia/a?oueny
aeinoia??ia ??cieoey a a?e i?aeaeuaiiy cia/aiue EIAA o oai?eo ia
ia?e?inii?ci ia 4,20,1 ?iee (p0,01).

Ii iiaeae? IOAA ?iaeea?aeoaeuei? cia/aiiy o oai?eo ia ia?e?inii?ci
ia?aaeuothoue iaeaaei? aaee/eie o /ieia?e?a – ia 1,80,7 ?iee (p0,05), o
ae?iie – ia 1,30,6 ?iee (p0,05), a ia?aeiai?e ii noao? aea??oe? – ia
1,60,5 ?iee (p0,01).

Ii iiaeae? IAA na?aaeiy aaee/eia ia?aa?eueoaiiy ?iaeea?aeoaeueieo
cia/aiue iaae iiioeyoe?eiei noaiaea?oii neeaaea? aeey /ieia?e?a -3,61,1
?iee (p0,01), aeey ae?iie – 3,31,2 ?iee (p0,01), a ia?aeiai?e ii noao?
aea??oe? – 3,50,8 ?iee (p0,01).

Oaeei /eiii, i?aaenoaaeaiee aiae?c na?aaei?o aaee/ei ??cieoe? i?ae
iieacieeaie AA o oai?eo ia ia?e?inii?ci ? iiioeyoe?eiei noaiaea?oii ii
an?i /ioe?ueii aeei?enoaiei iiaeaeyi ? na?aeioeoaii i?enei?aiiai oaiio
noa??iiy o oai?eo ia ia?e?inii?ci. Ca iaoeie aeaieie, oea ia?
a?aeiioaiiy ye aei ie?aieo ooieoe?iiaeueieo nenoai, oae ? aei oaiio
noa??iiy anueiai i?aai?cio a oe?eiio.

Ine?eueee ia?e?inii?ci ? a?e-caeaaeiei caoai?thaaiiyi, ie?aio
caoe?eaaeai?noue aeeeeeaei aea/aiiy a?ieia?/iiai a?eo oai?eo ia
ia?e?inii?ci a caeaaeiino? a?ae ?o eaeaiaea?iiai a?eo.

I?e ii??aiyii? ?iaeea?aeoaeueieo cia/aiue AA ii ??ciei iiaeaeyi ?c
na?aaeiueiiiioeyoe?eieie eiai cia/aiiyie, ui aecia/aeenue ca oi?ioeaie
IAA, aoei aeyaeaii ianooii? iniaeeaino?: ii iiaeae? ?AA o oai?eo ia
ia?e?inii?ci na?aaeiueiai a?eo ?iaeea?aeoaeuei? cia/aiiy noaoenoe/ii
aeinoia??ii ia?aaeuoaaee na?aaeiueiiiioeyoe?ei? cia/aiiy ? neeaaeaee
4,041,22 ?iee (p0,01), o iaoe??io?a iioeeiai a?eo ?iaeea?aeoaeuei?
cia/aiiy ia?aaeuoaaee na?aaeiueiiiioeyoe?ei? noaiaea?oe ia 3,782,09
?iee, iaeiae oe? ci?ie ia nyaathoue ??aiy noaoenoe/ii? aeinoia??iino?
(p0,05).

Ii iiaeae? EIAA noaoenoe/ii aeinoia??ieo ci?i ?iaeea?aeoaeueieo cia/aiue
a ii??aiyii? c iiioeyoe?eieie noaiaea?oaie o iaoe??io?a iaio a?eiaeo
a?oi ia aeyaeaii.

Ii iiaeae? IOAA ?iaeea?aeoaeuei? iieacieee noaoenoe/ii aeinoia??ii
ia?aaeuoaaee na?aaeiueiiiioeyoe?ei? cia/aiiy o oai?eo ia ia?e?inii?ci ye
na?aaeiueiai, oae ? iioeeiai a?eo.

Ii iiaeae? IAA a a?oi? iaoe??io?a na?aaeiueiai a?eo a?aei?/aeinue
noaoenoe/ii aeinoia??ia ca?eueoaiiy ?iaeea?aeoaeueieo cia/aiue AA a
ii??aiyii? c iiioeyoe?eieie noaiaea?oaie ia 4,860,91 ?iee (p0,01). O
iaoe??io?a iioeeiai a?eo aeai? iieacieee aeinoia??ii ia ci?ithaaeenue e
neeaaeaee 1,801,41 ?iee (p0,05).

Oaeei /eiii, anoaiiaeaii ia?aaeuaiiy cia/aiue AA iaae IAA o oai?eo ia
ia?e?inii?ci a a?eueo iieiae?e a?eia?e a?oi?, ui ? na?aeioeoaii iaio
?ioaineaiiai oaiio noa??iiy o oai?eo ia ia?e?inii?ci iioeeiai a?eo. Oea
iiaea aooe iiaycaii c a?eueoith o?eaae?noth oai?iae o /anoeie iaoe??io?a
aeaiiai a?eo ?, a?aeiia?aeii, c a?eueoith ae?aci?noth nooiaith oai?iae,
ui iaiaaeo? ?o aeeth/aiiy a ianoaaeaio iaie aea??eo. Iiaeeeaa, oaeiae, ?
oa ianoaaeia, ui ?c c?inoaiiyi eaeaiaea?iiai a?eo aeieea? i?e?iaeia
ciaioaiiy a iiioeyoe?? e?eueeino? in?a c i?enei?aiei oaiiii noa??iiy
?c-ca ?o nia?o?. Ci?ie a?ieia?/iiai a?eo o oai?eo ia ia?e?inii?ci, ui
aeyaeai? a iaoeo aeine?aeaeaiiyo, iiaeia iiynieoe aieeaii iaio
aeuaiienaieo oaeoi??a.

I?e aiae?c? oaiio noa??iiy o oai?eo ia ia?e?inii?ci a caeaaeiino? a?ae
o?eaaeino? caoai?thaaiiy aoei anoaiiaeaii, ui o iaoe??io?a c o?eaae?noth
caoai?thaaiiy aei 3 ?ie?a aeinoia??ii? ??cieoe? i?ae iieacieeaie
?iaeea?aeoaeueieo oa iaeaaeieo cia/aiue a?ieia?/iiai a?eo i? ii iaei?e c
iiaeaeae ia aeyaey?oueny.

O iaoe??io?a c o?eaae?noth caoai?thaaiiy a?ae 3 aei 5 ?ie?a aeyaeyeinue
noaoenoe/ii aeinoia??ia ca?eueoaiiy ?iaeea?aeoaeueieo iieaciee?a AA a
ii??aiyii? c na?aaeiueiiiioeyoe?eieie aaee/eiaie ii iiaeaeyi IOAA – ia
2,431,02 ?iee (p0,05) oa IAA – ia 2,981,29 ?iee (p0,05); ii iiaeaeyi ?AA
oa EIAA ci?ie oeeo iieaciee?a ia nyaaee noaoenoe/ii aeinoia??iiai ??aiy.

O oai?eo ia ia?e?inii?ci c o?eaae?noth caoai?thaaiiy iiiaae 5 ?ie?a
aeyaeyeinue ia?aaeuaiiy ?iaeea?aeoaeueieo iieaciee?a AA iaae
iiioeyoe?eieie noaiaea?oaie ii iiaeae? ?AA – ia 3,301,50 ?iee (p0,05),
ii iiaeae? IOAA – ia 1,860,81 ?iee (p0,05) ? ii iiaeae? IAA – ia
4,281,30 ?iee (p0,01). Aeiyoeii ? iiaeaeue EIAA, aea ?iaeea?aeoaeuei?
cia/aiiy noaoenoe/ii aeinoia??ii ia a?ae??ciyeenue a?ae
na?aaeiueiiiioeyoe?eieo iieaciee?a, ui iiynith?oueny, ye neacaii aeua,
iniaeeainoyie oi?ioaaiiy aea??ee oai?eo ia ia?e?inii?ci.

Oaeei /eiii, i?e ca?eueoaii? o?eaaeino? caoai?thaaiiy ia ia?e?inii?ci
c?inoa? e?euee?noue ci?i a iieacieeao ?iaeea?aeoaeueieo aaee/ei AA, ui ?
na?aeioeoaii i?enei?aiiy oaiio noa??iiy ? a?aeia?aaeaiiyi cia/iiai
aieeao o?eaaeino? caoai?thaaiiy ia ia?e?inii?ci ia caaaeueiee oaii
noa??iiy i?aai?cio.

Iaie anoaiiaeaii, ui iaeieae/ee oaii noa??iiy a?aei?/a?oueny o oai?eo ia
ia?e?inii?ci iioeeiai a?eo c o?eaae?noth caoai?thaaiiy aei 3 ?ie?a –
iieaciee AA-IAA ii an?i iiaeaeyi aeinoia??ii ia ci?ithaaany. O a?oi?
oai?eo iioeeiai a?eo c o?eaae?noth caoai?thaaiiy a?eueoa 3 ?ie?a
aeinoia??ii ca?eueoeany eeoa iieaciee IOAA – ia 2,991,26 ?iee (?

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