OE?A?INUeEA AEAAeAI?ss AA?A?IEO IAOE

?INOEOOO CAIEA?IANOAA ? A?IEIA?? OAA?EI

?NE?A ?ONEAIA ss?INEAA?AIA

OAeE 591.111.1:612.419:577.15:577.17:577.118

AI?IIIAEUeII-NOANO?AOI? IAOAI?CIE ?AAOEssOe??

AOAEAAIAeIIAI IAI?IO OA AIOEIENEAeAIOII? NENOAIE

A I??EI?AeIEO EE?OEIAO ? EAEEIOeEOAO NAEIAE ?AIIUeIAI A?EO

03.00.04 — a?io?i?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa n?euenueeiainiiaea?nueeeo iaoe

Euea?a-1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? caiea?ianoaa ? a?ieia?? oaa?ei OAAI ( i.
Euea?a )

Iaoeiaee ea??aiee: aeieoi? a?ieia?/ieo iaoe, i?ioani?,

/eai-ei?aniiiaeaio OAAI,

Caneoaeaiee ae?y/ iaoee ? oaoi?ee
Oe?a?ie

NI?OEINUeEEE Aieiaeeie? Aaneeueiae/,

Euea?anueeee aea?aeaaiee Aa?a?iee
oi?aa?neoao, ?aeoi?

Io?oe?ei? iiiiaioe: aeieoi? a?ieia?/ieo iaoe, i?ioani?

NIEIAOA Eaii?ae ?ee?/,

?inoeooo caiea?ianoaa ? a?ieia??
oaa?ei OAAI,

caa?aeoaa/ eaai?aoi???th iai?io
?a/iaei;

aeieoi? a?ieia?/ieo iaoe

EOOeEE Iaenei Aeieo?iae/,

A?aeae?eaiiy ?aaoeyoi?ieo nenoai ee?oeie ?inoeoooo

i. I.A. Iaeaae?ia, i?ia?aeiee iaoeiaee ni?a?ia?oiee

a?aeae?eo ?aaoeyoe?? ee?oeiii? i?ie?oa?aoe??

I?ia?aeia onoaiiaa: Oa?e?anueeee ciiaaoa?eia?iee ?inoeooo

I?i?no?a?noaa aa?ii?iieneiaiai
eiiieaeno Oe?a?ie,

eaoaae?a a?io?i??

Caoeno a?aeaoaeaoueny “ 16 ” eeiiy 1999 ?. i 10-00 aiaeei? ia
can?aeaii?

niaoe?ae?ciaaii? a/aii? ?aaee Ae 35.368.01. a ?inoeooo? caiea?ianoaa ?
a?ieia?? oaa?ei OAAI ca aae?anith 290034, i. Euea?a, aoe. A. Noona, 38.

C aeena?oaoe??th iiaeia iciaeiieoeny o iaoeia?e a?ae?ioaoe? ?inoeoooo
caiea?ianoaa ? a?ieia?? oaa?ei OAAI ca aae?anith 290034, i. Euea?a, aoe.
A. Noona, 38.

Aaoi?aoa?ao ?ic?neaiee “ 28 ” o?aaiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
*a?e?i A. A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Iaei??th c aeooaeueieo iaoeiaeo ? i?aeoe/ieo
i?iaeai oaa?eiieoeoaa ? c’ynoaaiiy iieaeoey?ieo iaoai?ci?a iaiiaoaeueii?
aaeaioaoe?? iiaiia?iaeaeaieo oaa?ei. Ae??oaiiy oeueiai ieoaiiy
iaiiaeeeaa aac aeeaieiai i?ciaiiy a?io?i?/ieo i?ioean?a, ye? eaaeaoue a
iniia? eaeeioeeoiiiaco ? aeaoa?i?iothoue ??aaiue ?aaeoe?e ee?oeiiiai ?
aoii?aeueiiai ?ioi?oaoo a i?aai?ci? oaa?ei ?aiiueiai a?eo.

Ca?aeii aei aeaieo e?oa?aoo?e, ?aii?e iinoiaoaeueiee ia??iae
iioiaaiaco o nnaa-oe?a oa?aeoa?eco?oueny iaaieie iniaeeainoyie, na?aae
yeeo — i?aeaeuaia /ooeea?noue aei iaoiaaiieo aieea?a, ui coiiaeth?oueny
iecueeith ?ioiiith ?aaeoeai?noth i?aai?cio iiaiia?iaeaeaiiai [Aeaaen
I.A., Aioaoi?n Ae.,1987; Burgio G.R. et al, 1987]. I?e/e-iaie neaaeiai
?ioi?oaoo a ?aiiueiio a?oe? ? iecueeee ??aaiue i??ei- ? e?ioioeeoiiiaco
i?e ia?iaeaeaii?, a oaeiae iaaeinoaoiy ooieoe?iiaeueia aeoeai?noue
iaeo?io?eueieo a?aioeioeeo?a, ui i?iyaey?oueny o iecuee?e caeaoiino?
aei oaiioaeneno, aeaa?aioeyoe?? oa aaeoa?eoeeaeii? ae?? [Ieoaeeiaa C.I.
e ae?., 1981; Hill H.R., 1987]. Iacaaaeath/e ia ?yae aeine?aeaeaiue,
iaoai?cie, ui eaaeaoue a iniia? cieaeaii? ?aaeoeaiino? iaeo?io?eueieo
a?aioeioeeo?a iiaiia?iaeaeaieo, c’yniaai? iaaeinoaoiuei [Ieaa?aaneee
A.A.. e ae?., 1988; Oi?oaa?iaa I.A., 1991; Aioiiye ? ni., 1996]. ?acii c
oei a?aeiii, ui a ?aae-oe?yo ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo
aaaeeeaa ?ieue iaeaaeeoue i?ioeanai aia?aa-oe/iiai iai?io a eaeeioeeoao
e?ia? oa ?o iiia?aaeieeao a i?aaiao aaiiiiaco [Masters C., 1992; Cai
T.Q., Wright S.D., 1995; Aioiiye A.E. ? ni., 1997]. ?ioaineai?noue
eaoaaie?cio aoaeaaiae?a aeaoa?i?io?, c iaei??? noi?iie, ??aaiue
aia?aicaaacia/aiiy ee?oei i?e a?aioei- ? e?ioioeeoiiiac?, a c ?ioi? —
oaeaee?noue ooai?aiiy a?aeiiaeaieo oi?i iieaeoe eioaeoi?a
NADPH-ieneaeace, iaiao?aeieo aeey i?aeo?eiaiiy aaeoa?eoeeaeii?
aeoeaiino? c??eeo iaeo?io?e?a [Thomas P.D. at al, 1993; Theron A.J. et
al., 1994].

A?aeiia?aeiee ??aaiue aia?aaoe/iiai iaoaaie?cio ia? aaaeeeaa cia/aiiy ?
aeey caaacia/aiiy ooieoe?iiaeueii? aeoeaiino? aioeieneaeaioii? nenoaie a
ee?oeiao i??ei-?aeiiai ?yaeo oa a e?ioioeeoao. Eaoae?oe/ia aeoeai?noue
oa?iaio?a aioeieneaeaioii? nenoaie, yea ?aaoeth? ??aaiue i?ioean?a
a?eueii?aaeeeaeueiiai ieeniaiiy a ee?oeiao, ca-aacia/o? i?aeo?eiaiiy
noaa?eueiino? ?o ieaciaoe/ieo iaia?ai ? aioo??oiueiee?oeiieo no?oeoo? a
oiiaao ieneaeaoe?eiiai no?ano, oa?aeoa?iiai aeey ?aiiueiai ia??iaeo
i?ney ia?iaeaeaiiy [Aeaaeeie?ia TH.A., 1989; Iaiueoeeiaa A. A., Caieia
I. E., 1993].

Iniaeeaino? i?io?eaiiy aia?aaoe/ieo i?ioean?a ? iaoaaie?/iee ca’ycie
inoai-i?o c ooieoe?iiaeueiei noaiii aioeieneaeaioii? nenoaie, a oaeiae
o/anoue ai?iiiaeue-ieo ? ae?iaioa?ieo oaeoi??a o ?aaoeyoe?? iaoaaie?cio
a i??eiea??ioeeoao aaiiiiaoe/ii? oeaieie ? eaeeioeeoao e?ia? oaa?ei i?e
ia?aoiae? a?ae i?a- aei iinoiaoaeueiiai iioiaaiaco aea/ai?
iaaeinoaoiuei [Strauss R.G., Mauer A.M, 1978; Nieoeineee A.A. e ae?.,
1995; Aioiiye ? ni., 1997, 1998]. Cie?aia, oea noino?oueny ?ie?
a?ae?iei?oeciio, iaeiiai c aaeaioaoe?eieo ai?iii?a, o ooieoe?iioaaii?
nenoaie eaeeioeeoiiiaco oa a ci?iao ni?aa?aeiioaiiy i?ae ?ioaineai?noth
i?io?eaiiy ie?aieo oeyo?a eaoaaie?cio aoaeaaiae?a a eaeeioeeoao naeiae a
?aiiueiio iinoiaoaeueiiio ia??iae? iioiaaiaco.

Aaaeeeaa cia/aiiy aeey oi?ioaaiiy a i?aai?ci? aaeaioaoe?eieo iaoai?ci?a
oa i?aeo?eiaiiy ?ioiiiai aiiainoaco ia? aaeaeaaoia caaacia/aiiy oaa?ei
?aiiueiai a?eo i?ia?aeueieie ?a/iaeiaie, cie?aia, ?iiaie cae?ca ?
naeaio. A ?yae? aeine?aeaeaiue iieacaii, ui cae?ci ? eiiiiiaioii
aaaaoueio iaoaaie?/ieo nenoai, aoiaeeoue aei neeaaeo oa?iaio?a, ui
eaoae?cothoue ieenii-a?aeiiai? i?ioeane [Aaeion A.I., Eiiiee E.I.,1991;
Eoayiiaa E.I., 1998]. Oeae i?e?iaeaiaio caaacia/o? ooieoe?iiaeueio
aeoeai?noue eaeeioeeo?a oa ?o caeaoi?noue aei aaeoa?eoeeaeii? ae?? ?
aeanoo?ainoi?iaoe?? [Genrke M., 1989; Kemp J.D., 1993]. Naeai —
no?oeoo?iee aeaiaio aioeieneaeaioii? nenoaie, i?eeia? o/anoue o
aaaaoueio aeeoo?aiiaiao?aeieo i?ioeanao a i?aai?ci? nnaaoe?a ? ? iaeiei
?c ?aaoeyoi??a ?aaeoe?e ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo [Spallholz
J.E., 1990; Wendel A., 1992; Ni?oeinueeee A.A., Aioiiye A.E., 1994].

A ca’yceo c oeei, cia/iee ?ioa?an noaiiaeyoue aeine?aeaeaiiy, nea?iaai?
ia c’yno-aaiiy iioiaaiaoe/ieo iniaeeainoae eaeeioeeoiiiaco oa aieeao
a?ae?iei?oeciio ? i?e?iaeaiaio?a (Fe, Se) ia ?aaoeyoe?th iaoaaie?/ieo
i?ioean?a a i??ei?aeieo ee?oeiao aaiiiiaoe/ii? oeaieie ? eaeeioeeoao
e?ia? ii?inyo a ?aiiueiio ia??iae? iinoiaoaeueiiai iioiaaiaco.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa ?
o?aaiaioii oaie UA ? 0196E010486, oeo? “Aea/eoe iieaeoey?i? iaoai?cie
oi?ioaaiiy nenoaie ?aaoeyoe?? iaoaaie?cio, aaiiiiaco oa ?ioiii? ooieoe??
o naeiae ? aaeeei? ?iaaoi? ooaeiae ia ?aii?o aoaiao iinoiaoaeueiiai
?icaeoeo”, aeeiiaia a eaai?aoi??? aiaeie?eiii? ?aaoeyoe?? ?inoeoooo
caiea?ianoaa ? a?ieia?? oaa?ei OAAI.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Aeine?aeeoe ?ioaineai?noue
eaeeioeeoiiiaco, aia?aaoe/iiai iaoaaie?cio, i?ioaie?co ? noai
aioeieneaeaioii? nenoaie a ee?oeiao i??ei?aeiiai ?yaeo e?noeiaiai iiceo,
iaeo?io?eueieo a?aioeioeeoao ? e?ioioeeoao ia?eoa??eii? e?ia? naeiae a
ia??iae? a?ae ia?iaeaeaiiy aei 10-aeiaiaiai a?eo oa c’ynoaaoe aieea
a?ae?iei?oeciio ? i?e?iaeaiaio?a (Fe, Se) ia ?aaoeyoe?th iaoaaie?cio a
ee?oeiao aeacaieo iiioeyoe?e.

Aeey ae??oaiiy aeaii? i?iaeaie aoee iinoaaeai? ianooii? caaaeaiiy:

aea/eoe aeeiai?eo iiioeyoe?e ee?oei i??ei?aeiiai ? e?ioi?aeiiai ?yaeo a
e?noeiaiio iiceo ? ia?eoa??ei?e e?ia? naeiae a ia??iae? a?ae
ia?iaeaeaiiy aei 10-aeiaiaiai a?eo oa ci?ie ?o ai?noo i?ae aieeaii
a?ae?iei?oeciio;

aeine?aeeoe ci?ie ?ioaineaiino? ie?aieo aoai?a aia?aaoe/iiai iai?io a
i??ei?ae-ieo ee?oeiao ? a eaeeioeeoao naeiae o a?eiaiio aniaeo?, i?ae
aieeaii a?ae?iei?oe-ciio, cae?ciaeaeno?aiiaiai i?aia?aoo
“Aeaeno?ioa?-100 ” ? naeai?oo iao??th oeyoii aecia/aiiy aeoeaiino?
aaenie?iace, oinoio?oeoie?iace, i??oaaoe?iace, eaeoaoaeaa?ae?iaaiace,
aetheici-6-oinoaoaeaa?ae?iaaiace, ?cioeeo?aoaeaa?ae?iaaiace ? oeeoio?ii
n-ieneaeace;

aea/eoe ci?ie aioeieneaeaioiiai noaoono i??ei?aeieo ee?oei e?noeiaiai
iiceo ? e?ia? naeiae o a?eiaiio aniaeo?, i?ae aieeaii a?ae?iei?oeciio,
cae?ciaeaeno?aii-aiai i?aia?aoo “Aeaeno?ioa?-100 ” ? naeai?oo iao??th
oeyoii aecia/aiiy aeoeaiino? noia?ieneaeaeeniooace,
aeooao?iiia?ieneaeace ? aeooao?ii?aaeoeoace;

c’ynoaaoe ci?ie aeoeaiinoae oa?iaio?a i?ioaie?co o a?eiaiio aniaeo?,
i?ae aieeaii a?ae?iei?oeciio, cae?ciaeaeno?aiiaiai i?aia?aoo
“Aeaeno?ioa?-100” ? naeai?oo iao??th;

aeine?aeeoe ai?iiiaeueiee noaoon naeiae a ?aiiueiio iinoiaoaeueiiio
ia??iae? iioiaaiaco.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aea/aii a?eiao aeeiai?eo
iiioeyoe?e i??ei?aeieo ee?oei e?noeiaiai iiceo naeiae a ?aiiueiio
iinoiaoaeueiiio ia??iae? iioiaaiaco. Aeine?aeaeaii ci?ie ?ioaineaiino?
ie?aieo eaiie eaoaaie?cio iiiinaoa?e-ae?a oa noai aioeieneaeaioii?
nenoaie a ee?oeiao i??ei?aeiiai ?yaeo e?noeiaiai iiceo ? eaeeioeeoao
naeiae a ia??iae? a?ae ia?iaeaeaiiy aei 10-aeiaiaiai a?eo. Aia?oa
anoaiiaeaii ci?ie aeoeaiino? ie?aieo oeeoiieaciaoe/ieo ?
i?oioiiae??aeue-ieo oa?iaio?a aia?aaoe/iiai iai?io, i?ioaie?co oa
aioeieneaeaioii? nenoaie i?ae aieeaii a?ae?iei?oeciio,
cae?ciaeaeno?aiiaiai i?aia?aoo “Aeaeno?ioa?-100 ” ? naea-i?oo iao??th.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?iaioa i?enay/aia aea/aiith
iioiaaiaoe/ieo iniaeeainoae eaeeioeeoiiiaco ? iaoaaie?cio i??ei?aeieo
ee?oei ? eaeeioeeo?a oa nea?iaaia ia c’ynoaaiiy a?io?i?/ieo iaoai?ci?a,
ye? eaaeaoue a iniia? caaacia/aiiy aeeoo?caeaoiino? iiaiia?iaeaeaiiai
i?aai?cio ? eiai aaeaioaoe?eieo iiaeeeainoae a ?aiiueiio iinoiaoaeueiiio
ia??iae? ?icaeoeo. ?acoeueoaoe aeine?aeaeaiue iiaeooue aooe oai?aoe/iith
iniiaith aeey ?ic?iaee aaeaioiaaiieo oaoiieia?e oa ?ioiiiiaeoeyoi??a c
iaoith i?aeaeuaiiy caa?aaeaiiy oa ?ioaineo?eaoe?? ?inoo iieiaeiyea
i?ioyaii e?eoe/ieo ia??iae?a iioiaaiaco.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai aeanii?o/ii i?iaaaeaii an?
aenia?eiaioaeuei? aeine?aeaeaiiy, a oaeiae cae?eniaii noaoenoe/io oa
aiae?oe/io ia?iaeo iaea?aeaieo ?acoeueoao?a.

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?eii? ?iaioe aeiiia?aeaeenue ia:
iaoeia?e eiioa?aioe?? “Aeooaeueiua i?iaeaiu aeieiaee a aeeaioiiaiaenoaa”
(Ai?iane, 1995);

iaoeia?e eiioa?aioe??, i?enay/ai?e 100-??//th eaoaae?e o?c?ieia??
Euea?anueeiai ia-aee/iiai ?inoeoooo (Euea?a, 1995); i?aeia?iaeiiio
neiiic?oi? “ A?ieia?/i? iaoai?cie noa??iiy” (Oa?e?a, 1996);
i?aeia?iaei?e iaoeia?e eiioa?aioe?? iieiaeeo a/aieo (Oa?e?a, 1997); VII
a?io?i?/iiio c’?cae? (Ee?a, 1997); XVII conf. “Dni fyziologie
hospo-darskych zvierat” (Kosice, 1997); OV c’?cae? Oe?a?inueeiai
o?c?ieia?/iiai oiaa?enoaa (Aeiiaoeuee, 1998); i?aeia?iaei?e eiioa?aioe??
“A?ieia?/i? iniiae aeeaeaiiy n?euenueei-ainiiaea?nueeeo oaa?ei” (
Euea?a, 1998).

Ioae?eaoe??. Ca ?acoeueoaoaie aeine?aeaeaiue iioae?eiaaii 20 iaoeiaeo
?ia?o, c ieo — 10 noaoae.

No?oeoo?a ? ia’?i ?iaioe. Aeena?oaoe?y iaienaia ia 169 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e,
iaoa??aeo ? iaoiaeeee aeine?aeaeaiue, aeanieo aeine?aeaeaiue,
iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiue, aeniiae?a oa nieneo e?oa?aoo?e,
yeee aeeth/a? 424 aeaea?aea. O aeena?oaoe?? i?noeoueny 14 oaaeeoeue, 10
?enoie?a oa 1 aeiaeaoie.

IAOA??AEE ? IAOIAeE AeINE?AeAEAIUe

Aenia?eiaioaeueia /anoeia ?iaioe aeeiiaia c aeei?enoaiiyi 60 ii?inyo
a?eii aei 10 ae?a a?ae ia?iaeaeaiiy c aeeaith ianith 1-3 e?eia?aie,
io?eiaieo a?ae naeiiiaoie aaeeei? a?ei? ii?iaee a niaoeainiiaea?noaao
Ao/aoeueeiai ?aaeainio-oaoi?eoio Oa?iii?euenueei? iaeano?. Ii?inyoa
oo?eioaaeeny i?ae naeiiiaoeaie, aiae?aey yeeo cae?enithaaeany ca?aeii
aeaoae?ciaaieo ii?i [Eaeaoieeia A.I. e ae?., 1985].

I?e aeine?aeaeaii? aieeao a?ae?iei?oeciio ia ?ioaineai?noue
eaeeioeeoiiiaco ? iaoaaie?cio i??ei?aeieo ee?oei ? eaeeioeeo?a
7-aeiaiaei ii?inyoai aeine?aeii? a?oie aioo??oiueii’yciai aaiaeeee
a?ae?iei?oecii (40 ia/ea iane oaa?ei eiaei? 12 aiaeei i?ioyaii 3-o
ae?a).

Aeine?aeaeaiiy, nea?iaai? ia aea/aiiy aieeao cae?ca ? naeaio ia
iaoaaie?ci i??ei?aeieo ee?oei ? eaeeioeeo?a i?iaiaeeeenue ia 3-o a?oiao
ii?inyo 1-10-aeiaiaiai a?eo, ii 15 oaa?ei o eiaei?e. Oaa?eiai 1-?
aeine?aeii? a?oie /a?ac 48 aiaeei i?ney ia?iaeaeaiiy aioo??oiueii’yciai
aaiaeeee 2 ie cae?ciaeaeno?aiiaiai i?aia?aoo “ Aeaeno?ioa?-100”, 1 ie
yeiai i?noeoue 100 ia Fe3+, c ?ic?aooieo 2ie/ea iane o?ea. Oaa?eiai 2-?
aeine?aeii? a?oie — /a?ac 24 aiaeeie i?ney ia?iaeaeaiiy
aioo??oiueii’yciai aaiaeeee ?ic/ei naeai?oo iao??th c ?ic?aooieo 0,075
ia naeaio/ea iane, a /a?ac 48 aiaeei i?ney ia?iaeaeaiiy — 2 ie
aeaeno?ioa?o. Ii?inyoai eiio?ieueieo a?oi cai?noue aeuaaeacaieo
i?aia?ao?a aaiaeeee a?aeiia?aeiee ia’?i 0,9 % ?ic/eio NaNl.

Iaoa??aeii aeey aeine?aeaeaiue aoee ia?eoa??eia e?ia ? aaiiiiaoe/ia
oeaieia e?noeiaiai iiceo naeiae, io?eiai? i?ioyaii 1-? aiaeeie i?ney
ia?iaeaeaiiy ? ia 1-, 3-, 5- 10-o aeiae aeeooy. E?ia io?eioaaee oeyoii
ioieoe?? ia?aaeiuei? ii?iaeienoi? aaie. E?noeiaee iicie aeae?eyee i?ney
aeaeai?oaoe?? oa iaace?iaeaiiy oaa?ei. O?aeoe?i-ioaaiiy ee?oei
e?noeiaiai iiceo ? e?ia? i?iaiaeeee a a?aae??io? aonoeie
o?eie-aa?i-a?ao?io [Boyum A.A., 1968; Harrison F.L. et al., 1981].

Oeeoieia?/iee aiae?c ee?oei i?iaiaeeee oeyoii oa?aoaaiiy o?eniaaieo
iaoaiieii aenooaieo iace?a ca aeiiiiiaith aaiceaeeio ? ?ic/eio
A?ica-?iiaiianueeiai. Eeaneo?eaoe?th i??ei?aeieo aeaiaio?a i?iaiaeeee
ca?aeii caaaeueiii?eeiyoi? iaoiaeeee [Aaca?iiaie I.A., Ai?iaueaaa A.E.,
1991].

A ieaci? e?ia? aeine?aeaeoaaee eiioeaio?aoe?th ai?iii?a ?inoe?io,
oe?ieneio, o?eeiaeoe?ii?io oa a?ae?iei?oeciio ?aae?i?ioiieia?/iei
iaoiaeii c aeei?enoaiiyi iaai??a o??ie «OIIEAIE — IAINE» (Aaea?onue).

Ai?no ?inoe?io a e?ia? aecia/aee c aeei?enoaiiyi iaai?o
?EI-EIN-IA-125?, ai?no a?ae?iei?oeciio — NOA?II-E- 125?-M,
3,3′,5-o?eeiaeoe?ii?io — ?EI-O3-IA, oe?ieneio — ?EI-O4-IA.
Eiioeaio?aoe?th ai?iii?a a e?ia? aecia/aee ia e?/eeueieeo
g-aei?ii?ithaaiiy «COMPI-GAM-MA 1282». ?ic?aooiee cae?enithaaee a
eii?aeeiaoao «logit-log».

Aeoeai?noue aaenie?iace (EO 2.7.1.1), i??oaaoe?iace (EO 2.7.1.40),
eaeoaoaeaa?ae-?iaaiace (EO 1.1.1.27), oinoio?oeoie?iace (EO 2.7.1.11),
?cioeeo?aoaeaa?ae?iaaiace (EO 1. 1. 1. 40),
aetheici-6-oinoaoaeaa?ae?iaaiace (EO 1.1.1.49) aecia/aee
niaeo?ioioiiao?e/ieie iaoiaeaie, ui aacothoueny ia aeei?enoaii?
ni?yaeaieo nenoai ieeneaiiy aai a?aeiiaeaiiy i?eioeiai?aeieo eioa?iaio?a
[Anoao?ia A.E., 1974; Nieoeineee A. A., ssiiae/ A. A., 1984].
Aeoeai?noue oeeoio?iiieneaeace (EO 1. 9 3. 1) aecia/aee ca iaoiaeii,
yeee aaco?oueny ia aecia/aii? oaeaeeino? ieeneaiiy oeei oa?iaioii
a?aeiiaeaiiai oeeoio?iio-n [Cooperstein S.J., Lazarow A., 1951].
Aeoeai?noue aeooao?iiia?ieneaeace (EO 1.11.1.9) aecia/aee ca
oaeaee?noth ieeneaiiy aeooao?iio a i?enooiino? a?ae?iia?aeeno o?aoeiiiai
aooeeo [Iiei A. I., 1986], aeooao?ii?a-aeoeoace ( EO 1.6.4.3.) — ca
oaeaee?noth a?aeiiaeaiiy aeooao?iio a i?enooiino? NADPH [Aeaniaa N. e
ae?. 1990]. Aeoeai?noue noia?ieneaeaeeniooace (EO 1.15.1.11) aecia/aee
iiaeeo?eiaaiei iaoiaeii, a?aoiaoth/e ??aaiue ?ia?aoaaiiy a?aeiiaeaiiy
i?o?ineiuei-ai oao?acieth a i?enooiino? NADH ? oaiaceiiaoanoeueoaoo
[Aioiiye A.E., Ao/ei I.I., 1998]. Aeoeai?noue eaeia?i?a (Na2+- caeaaeieo
iaeo?aeueieo i?ioa?iac) ? eaoainei?a (eeneeo i?ioa?iac) aecia/aee ca
?ioaineai?noth ooai?aiiy eeneioi?ic/eiieo i?iaeoeo?a oa?iaioaoeaiiai
a?ae?ie?co a?eeiaeo noano?ao?a [I?aoiae/ I.A., 1977; Kevin K.W. et al.,
1988]. Eiioeaio?aoe?th a?eeo a e?caoao i??ei?aeieo ee?oei e?noeiaiai
iiceo ? eaeeioeeo?a e?ia? aecia/aee ca iaoiaeii Eio?? (1951). Io?eiai?
aeai? ii?aoeueiaoaaee noaoenoe/ii ca iaoiaeii Iea?ia (1960).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Ci?ie iiioeyoe?eiiai neeaaeo eaeeioeeo?a e?ia? ? ee?oei e?noeiaiai
iiceo naeiae a ?aiiueiio ia??iae? i?ney ia?iaeaeaiiy. ?acoeueoaoe
i?iaaaeaieo aeine?aeaeaiue aeacothoue ia oa, ui a ?aiiueiio ia??iae?
iinoiaoaeueiiai iioiaaiaco a?aeaoaathoueny cia/i? ci?ie o
ooieoe?iiaeuei?e aeoeaiino? e?iaioai?ii? nenoaie. Oae, ia?eoa??eia e?ia
iiaiia?iaeaeaieo ii?inyo oa?aeoa?eco?oueny cia/iei ai?noii ee?oeiieo
eiiiiiaio?a eaeeioeeoiiiaco. I?ioa, i?ioyaii ia?oeo ae?a aeeooy
a?aenioeiaee ai?no iaeo?io?e?a, iniaeeai, ?o iac??eeo oi?i o
ia?eoa??ei?e e?ia? oaa?ei cia/ii ciaioo?oueny, aeinyaath/e iaeieae/iai
??aiy o 10-aeiaiaeo ii?inyo. Ai?no e?ioioee-o?a o oee?eoeyoe?? oaa?ei
a??ia?aeii c?inoa? i?ioyaii ia?oeo 10-oe ae?a iinoiaoaeueiiai aeeooy.

A aaiiiiaoe/i?e oeaiei? iiaiia?iaeaeaieo ii?inyo niinoa??aa?oueny
iecueeee ai?no ee?oei i??ei?aeiiai ?yaeo, ui na?ae/eoue i?i iecueeo
?ioaineai?noue a?aioeioeeoiiiaco. I?ioa, ii/eiath/e c 3-aeiaiaiai a?eo a
e?noeiaiio iiceo ii?inyo a?aeaoaa?oue-ny aeoeaaoe?y oeueiai i?ioeano. O
10-aeiaiaeo ii?inyo ni?aa?aeiioaiiy i?ae ai?noii ee?oei i??ei?aeii? ?
a?eo?i?aeii? e?i?e a aaiiiiaoe/i?e oeaiei? noaiiaeoue 2 : 1 ? ee-oa a
iacia/i?e i??? ci?ith?oueny ai?iaeiaae iiaeaeueoiai ?icaeoeo.

Oaeei /eiii ?acoeueoaoe aeine?aeaeaiue aeacothoue ia oa, ui a ia??iae?
a?ae ia?iaeaeaiiy aei 10-aeiaiaiai a?eo o naeiae cia/ii ci?ith?oueny
ooieoe?iiaeueia aeoeai?noue e?iaioai?ii? nenoaie, yea iieyaa? o
iinooiia?e ?ioaineo?eaoe?? i?ioean?a i??ei- ? e?ioioeeoiiiaco.

Iaoaaie?ci a i??ei?aeieo ee?oeiao oa eaeeioeeoao naeiae a ?aiiueiio
iinoiaoaeueiiio ia??iae? iioiaaiaco. Aeey caaacia/aiiy aeniei?
?ioaineaiino? i?ioean?a i?ie?oa?aoe?? i??ei?aeieo ee?oei oa ?o
oa?i?iaeueii? aeeoa?aioe?aoe?? a e?noeiaiio iiceo ? oee?eoeyoe?? oaa?ei
iaiao?aeia i?aeo?eiaiiy a oeeo ee?oeiao aaeaeaaoiiai ??aiy aia?aaoe/iiai
iai?io. Aia?aaoe/iei i?ioeanai iaeaaeeoue aaaeeeaa ?ieue ? a ?aaeoe?yo
ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo [Strauss R.G., Mauer A.M., 1978].

A i?ioean? aeine?aeaeaiue anoaiiaeaii, ui eaeeioeeoe e?ia?, a oaeiae ?o
iiia?aaeieee o aaiiiiaoe/i?e oeaiei? e?noeiaiai iiceo naeiae
oa?aeoa?ecothoueny aenieith ?ioaineai?noth eaoaaie?cio aetheice.

— i??eiea??ioeeoe — e?ioioeeoe —
iaeo?io?ee

?en.2.Aeoeai?noue oa?iaio?a aia?aaoe/iiai iai?io a i??eiea??ioeeoao,
iaeo?io?eueieo a?aioeioeeoao ? e?ioioeeoao naeiae (I±m, n=5):
A-aaenie?iaca (iiieue NADPH/oa o ia a?eea), A-i??oaaoe?iaca (iiieue
NAD+/oa o ia a?eea), A-aetheici-6-oinoaoaeaa?ae?iaaiaca (iiieue NADPH/oa
o ia a?eea), A-oeeoio?ii n-ieneaeaca (oi.iae./oa o ia a?eea).

?acii c oei, ?ioaineai?noue ie?aieo eaiie aia?aaoe/iiai iaoaaie?cio
??cei cieaeo?oueny i?e aeeoa?aioe?aoe?? i??eiea??ioeeo?a aei c??eeo
a?aioeioeeo?a, cie?aia, oea noino?oueny aaenie?iace ?
aetheici-6-oinoaoaeaa?ae?iaaiace (?en. 1).

Ca?aeii aei ?acoeueoao?a aeine?aeaeaiue i?ioyaii 10-aeiaiaiai ia??iaeo
i?ney ia?iaeaeaiiy o ee?oeiao i??ei?aeiiai ?yaeo e?noeiaiai iiceo ?
eaeeioeeoao e?ia? ii?inyo aeoeao?oueny i?ioean aiaa?iaiiai ?icuaieaiiy
aetheice ? c?inoa? ?ioaineai?noue aeei?enoaiiy aetheici-6-oinoaoo a
iaioicioinoaoiiio ooio? ae?eie?co (aeea. ?en. 1). Oaea iaoaaie?/ia
neooaoe?y ia? aaaeeeaa cia/aiiy ia eeoa a a?aioeioeeoiiiac?, aea ? a
caaacia/aii? ooieoe?iiaeueii? aeoeaiino? c??eeo eaeeioeeo?a e?ia?.
Aaeaea a?aeiii, ui oae? ooieoe?? eaeeioeeo?a ye oaiioaenen,
aeaa?aioeyoe?y, oaaioeeoic caaacia/othoueny aia?a??th, aieiaiei /eiii,
ca ?aooiie aiaa?iaiiai ?icuaieaiiy iiiinaoa?eae?a [Arown E.J., 1995].
?acii c oei, o ca’yceo c iacia/iith caeaoi?noth ee?oei i??ei?aeiiai
?yaeo aei neioaco io?ei?a iniiaia ?ieue iaioicioinoaoiiai oeyoo ?,
cie?aia aetheici-6-oinoaoaeaa?ae?iaaiacii? ?aaeoe?? a i??eiea??ioeeoao
iieyaa? o i?aeo?eiaii? aaeaeaaoiiai ??aiy NADPI, ui c iaei??? noi?iie ?
aeiiaoi?ii aiaeith i?e a?ineioac? aee?ieo eeneio, a c ?ioi? — eioaeoi?ii
NADPH — ieneaeacii? ? aeooao?ii?aaeoeoacii? nenoai [Strauss R.G., Mauer
A.M., 1978; Theron A.J., 1994]. Oiio ia?aaoaeiaa iaoaaie?cio a
i??ei?aeieo ee?oeiao o iai?yieo ?ioaineo?eaoe?? i?ioeano ieeneaiiy
aetheice a iaioicioinoaoiiio oeyoo ? aaaeeeaith aeey noaiiaeaiiy
aaeoa?eoeeaeii? ooieoe?? e?ia? a i?aai?ci? oaa?ei ?aiiueiai a?eo.

Ii?yae c aeoeaaoe??th iaioicioinoaoiiai oeyoo a ?aiiueiio
iinoiaoaeueiiio ia??iae? a ee?oeiao i??ei?aeiiai ?yaeo ? e?ioioeeoao
oaa?ei niinoa??aa?oueny aeoeaaoe?y NADP-?cioeeo?aoaeaa?ae?iaaiacii?
?aaeoe??, ui, i/aaeaeii, noi?iaiaeaeo?oueny i?aeae-uaiiyi ??aiy
aeei?enoaiiy a?aeiiaieo aea?aaeaio?a aiaeith nenoaiith
i?oioiiae-??aeueieo oeeoio?ii?a. Oae, aeoeai?noue oeeoio?ii n-ieneaeace
— eaoae?caoi?a inoaiiuei? eaiee eaioethaa ieenii-a?aeiiaieo i?ioean?a o
i??eiea??ioeeoao oa eaeeioeeoao e?ia? oaa?ei cia/ii c?inoa? i?ioyaii
ia?oeo ae?a aeeooy, ca?eueooth/enue a ee?oeiao 3-aeiaiaeo ii?inyo o 2 —
3 ?ace ii??aiyii c ??aiai, oa?aeoa?iei aeey iiaiia?iaeaeaieo (aeea.?en.
1). Aeniea ooieoe?iiaeueia aeoeai?noue oa?iaioo i?aeo?eio?oueny a
ee?oeiao aeine?aeaeoaaieo iiioeyoe?e ? i?ioyaii iiaeaeueoiai ?icaeoeo.

Oaeei /eiii, aenia?eiaioaeueii anoaiiaeaii, ui i?ioyaii ?aiiueiai
iinoiaoaeueiiai ia??iaeo a i??eiea??ioeeoao e?noeiaiai iiceo ?
eaeeioeeoao ia?eoa??eii? e?ia? a?aeaoaa?oueny ia?aaoaeiaa ie?aieo eaiie
iai?io ?a/iaei, yea a cia/i?e i??? nea?iaaia ia caaacia/aiiy
ooieoe?iiaeueii? aeoeaiino? c??eeo eaeeioeeo?a. Aaeaioaoe?ei? ci?ie
aia?aaoe/iiai iaoaaie?cio a iioiieiiiaoaioieo eeioeiao iieyaathoue,
aieiaiei /eiii, a ?ioaineo?eaoe?? ieenieo i?ioean?a, cie?aia
iaioicioinoaoiiai oeyoo ia?aoai?aiue iiiinaoa?eae?a oa aeoeaaoe??
i?oioiiae??aeueieo oeeoio?ii?a. ?acii c oei i?aeaeuaiiy aeoeaiino?
oa?iaio?a ae?eie?co a iaeo?io?eueieo a?aioeioeeoao, i/aaeaeii, ?
aaaeeeaei oaeoi?ii a aia?aicaaacia/aii? ee?oeiieo ooieoe?e oa
noaiiaeaiiy caoenii? caeaoiino? eaeeioeeo?a i?e ia?aoiae? oaa?ei aei
iinoiaoaeueiiai niiniao aeeooy.

A?aeiii, oi ?ioaineo?eaoe?y ieenieo i?ioean?a o ee?oeiao
noi?iaiaeaeo?oueny i?ae-aeuaiiyi eiioeaio?aoe?e i?iaeoeo?a iaiiaiiai
a?aeiiaeaiiy eeniaaeo iieaeoe [Ineiia A. I. e ae?., 1990; Yu B.P.,
1994]. A ca’yceo c oeei aaaeeeaa ?ieue o caoeno? a?ae ieeneaiiy a?eeiaeo
eiiiiiaio?a aioo??oiueiee?oeiieo ? ieaciaoe/ieo iaia?ai oa ?ioeo
ee?oeiieo no?oeoo? iaeaaeeoue nenoai? aioeieneaeaioiiai caoenoo ee?oei,
cie?aia oa?iaioai aeooao?iiiai? nenoaie ? noia?ieneaeaeeniooac?
[Aeoaeieia A.A., 1993; Iaiueoeeiaa A. A., Caieia I. E., 1993].

Aenia?eiaioaeueii anoaiiaeaii, ui ??aaiue eaoae?oe/ii? aeoeaiino?
aioeieneaeaioeo oa?iaio?a ? iecueeei o iiaiia?iaeaeaieo oaa?ei (?en.2),
i?ioa i?ney ia?iaeaeaiiy ?o aeoeai?noue a i??ei?aeieo ee?oeiao
e?noeiaiai iiceo ? eaeeioeeoao e?ia?

ii?inyo c?inoa?.

— i??eiea??ioeeoe — e?ioioeeoe —
iaeo?io?ee

?en.2 Aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie a i??eiea??ioeeoao
? eaeeioeeoao e?ia? naeiae (I±m, n=5): A-noia?ieneaeaeeniooaca
(oi.iae./oa o ia a?eea), A-aeo-oao?iiia?ieneaeaca (iiieue ieeneaiiai
aeooao?iio/oa o ia a?eea), A-aeooao?ii?aaeoe-oaca (iiieue NADP+/oa o ia
a?eea).

Oaeei /eiii, ?acoeueoaoe aeine?aeaeaiue aeacothoue ia oa, ui i?ioyaii
?aiiueiai iinoiaoaeueiiai ia?iiaeo aiaeaoaa?oueny oi?ioaaiiy
aioeieneaeaioii? caeaoiinoi eei-oei e?iai oa ?o iiia?aaeieeia o
aaiiiiaoe/iie oeaieii, noaiiaeaiiy ooieoeiiiaeueii? aeoeaiinoi
coia?ieneaeaeeniooace i oa?iaio?a aeooaoiiiiai? nenoaie.

Aenia?eiaioaeueii anoaiiaeaii, ui a i?ioean? iinoiaoaeueii? aaeaioaoe??
ci?ith-?oueny aeoeai?noue i?ioaie?oe/ieo oa?iaio?a a ee?oeiao nenoaie
aaiioeeoiiiaco. I?e oeueiio aeoeai?noue eaoainei?a a i??eiea??ioeeoao ?
eaeeioeeoao ii?inyo c?inoa? a ia-??iae? c 3-? ii 5-o aeiao
iinoiaoaeueiiai ?icaeoeo, a aeoeai?noue eaeia?i?a a??ia?aeii
ca?eueoo?oueny a i??ei?aeieo ee?oeiao e?noeiaiai iiceo ? e?ioioeeoao
10-aeiaiaeo ii?inyo o ii??aiyii? aei cia/aiue, oa?aeoa?ieo aeey
3-aeiaiaeo oaa?ei. Aeai? e?oa?aoo?e aeacothoue ia oa, ui oa?iaioe, ye?
iaeaaeaoue aei Na2+- caeaaeieo iaeo?aeueieo i?ioa?-iac a?ae?a?athoue
cia/io ?ieue o ooieoe?iiaeuei?e aeoeaiino? ee?oei, i?eeiath/e o/anoue o
o?ainaeoeoe?? neaiae?a ?inoiaeo oaeoi??a oa ?ioeo a?ieia?/ii aeoeaieo
?a/iaei [Melloni E. et al, 1986; Nieiaoa E.?. oa ni., 1992]. A ca’yceo c
oeei aeoeaaoe?y eaeia?i?a o i??eiea??ioeeoao aaiiiiaoe/ii? oeaieie oa
e?ioioeeoao iiaea na?ae/eoe i?i c?inoaiiy /ooeeaino? ee?oei aei ae??
a?i?aaoeyoi??a ? a?ae?a?aaaoe iaaio ?ieue o iaoai?ciao noaiiaeaiiy
caoenii? ooieoe?? e?ia? a i?aai?ci? oaa?ei i?ney ia?iaeaeaiiy.

Aieea a?ae?iei?oeciio ia eaeeioeeoiiiac ? iaoaaie?/io aeoeai?noue a
i??ei?aeieo ee?oeiao e?noeiaiai iiceo ? eaeeioeeoao e?ia? naeiae.
Aaaeeeaa ?ieue a ?aae?caoe?? aaeaioaoe?eiiai neiae?iio iaeaaeeoue
ai?iiiai ei?e iaaeie?iee?a, ine?eueee ia?ao?ae a?ae i?a- aei
iinoiaoaeueiiai ?icaeoeo ? neeueiei no?aniaei oaeoi?ii. A ?yae?
aeine?aeaeaiue anoaiiaeaii, ui eiioeaio?aoe?y a?ae?iei?oeciio a e?ia?
naeiae aeinyaa? cia/iiai ??aiy i?ioyaii ia?oeo aiaeei i?ney
ia?iaeaeaiiy [Ni?oeinueeee A.A. ? ni., 1994; Antonyak H.L., 1996]. A
ca’yceo c oeei i?iaiaeeeenue aeine?aeaeaiiy aieeao a?ae?iei?oeciio ia
?ioaineai?noue eaeeioeeoiiiaco oa iaoaaie?ci a eaeeioeeoao e?ia? ?
ee?oeiao e?noeiaiai iiceo ii?inyo.

Aenia?eiaioaeueii anoaiiaeaii, ui a?ae?iei?oecii a?ae?a?a? ?aaoeyoi?io
?ieue a e?iaioai?ieo i?ioeanao, a i?e canoinoaaii? o aenieeo
eiioeaio?aoe?yo oeae ai?iii i?eai?/o? ?ioaineai?noue a?aioeioeeoiiiaco.
Oaeei /eiii, ai?iiiaeueia neooaoe?y a i?aai?ci? iiaiia?iaeaeaieo oaa?ei,
cie?aia, aenieee ai?no a?ae?iei?oeciio a cia/i?e i??? coiiaeth? oa?aeoa?
aaiioeeoiiiaco a ?aiiueiio iinoiaoaeueiiio ia??iae? ?icaeoeo.

I?ney o?eaaeiai aaaaeaiiy a?ae?iei?oeciio a eaeeioeeoao ? ?o
iiia?aaeieeao a e?noeiaiio iiceo ii?inyo a?aeaoaa?oueny ia?aaoaeiaa
ie?aieo eaiie aia?aaoe/iiai iaoaaie?cio (oaae.1). Oae, i?ney ?i’?eoe?e
ai?iiio oaeaee?noue aaenie?iacii? ?aaeoe?? a i??eiea??ioeeoao ?
iaeo?io?eueieo a?aioeioeeoao ii?inyo cieaeo?oueny a?aeiia?aeii ia 32%
(?<0,001) ? 20% (?<0,01) (aeea. oaae.1), ui na?ae/eoue i?i i?eai?/aiiy ?ioainea-iino? ii/aoeiaeo noaae?e ae?eie?co ? iaioicioinoaoiiai oeyoo. ?acii c oei aeoeaaoe?y i??oaaoe?iacii? ?aaeoe??, ui niinoa??aa?oueny a ee?oeiao i?e iecuee?e ?ioaineaiino? ii/aoeiaeo noaae?e ae?eie?co ? iaioicioinoaoiiai oeyoo iiaea aeacoaaoe ia caeo/aiiy a i?ioean ae?eie?oe/iiai ?icuaieaiiy ?ioa?iaae?ao?a e?i?aeiiai iaoaaie?cio. I?e aeine?aeaeaii? ooieoe?iiaeueii? aeoeaiino? oeeoio?ii n-ieneaeace anoaiiaeaii cia/ia cieaeaiiy aeoeaiino? oa?iaioo a e?ioioeeoao i?e a?aeiini?e noaa?eueiino? oaeaeeino? oeeoio?ii n-ieneaeacii? ?aaeoe?? a iaeo?io?eueieo a?aioeioeeoao i?ney aaaaeaiiy a?ae?iei?oeciio (aeea. oaae.1). Oea iiaeeeai coiiaeth?oueny ieae/ith /ooeea?noth oa?iaioo a?aioeioeeo?a aei ae?? ?aaoeyoi?ieo oaeoi??a a ca'yceo c iaioei ooieoe?i-iaeueiei cia/aiiyi a oeeo ee?oeiao nenoaie ee?oeiiiai aeeoaiiy o ii??aiyii? aei ?ioiieiiiaoaioieo ee?oei [Strauss R.G., Mauer A.M., 1978]. A oie naiee /an o iaeo?io?eao oa ?o iiia?aaeieeao a e?noeiaiio iiceo ii?inyo aeine?aeii? a?oie ??cei cieaeo?oueny aeoeai?noue aetheici-6-oinoaoaeaa?ae?iaaiace (aeea. oaae.1). I/aaeaeii, iecueeee ??aaiue ooai?aiiy a ee?oeiao NADPH- eioaeoi?a aeooao?ii?aaeoeoace ? iaeiei c oaeoi??a, ui coiiaeththoue ciaioaiiy aeoeaiino? oa?-iaio?a aeooao?iiiai? nenoaie, yea niinoa??aa?oueny a eaeeioeeoao oaa?ei i?ney o?eaaeiai aaaaeaiiy a?ae?iei?oeciio. ?acii c oei a ee?oeiao on?o aeine?aeaeoaaieo iiioey-oe?e a??ia?aeii cieaeo?oueny aeoeai?noue noia?ieneaeaeeniooace. Oaaeeoey 1 - Aieea a?ae?iei?oeciio ia aeoeai?noue oa?iaio?a aia?aaoe/- iiai iai?io a i??eiea??ioeeoao ? eaeeioeeoao e?ia? naeiae (I±m; n=5) A?oie oaa?ei Ee?oeie Eiio?ieueia a?oia Aeine?aeia a?oia Aaenie?iaca (iiieue NADPI / oa o ia a?eea) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 16,50±1,20 7,74±0,41 10,20±0,92 11,23±0,24*** 6,14±0,32** 11,90±0,68 Oinoio?oeoie?iaca ( iiieue NAD+ / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 154,4±21,7 133,2±5,16 282,5±18,3 134,0±16,5 151,5±11,2 241,2±16,3 I??oaaoe?iaca ( iiieue NAD+ / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 39,8±2,4 25,4±1,3 33,0±1,9 65,89±4,58*** 72,35±8,31*** 119,4±12,4*** Eaeoaoaeaa?ae?iaaiaca ( iiieue NAD+ / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 78,5±6,8 166,5±10,0 124,3±12,9 37,7±2,0*** 76,3±5,6*** 125,4±7,6 Aetheici-6-oinoaoaeaa?ae?iaaiaca ( iiieue NADPI / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 64,9±4,6 8,15±0,68 7,45±0,38 28,5±1,8*** 2,32±0,11*** 5,16±1,3 NADP-?cioeeo?aoaeaa?ae?iaaiaca ( iiieue NADPI / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 4,78±0,21 3,80±0,46 9,42±0,60 7,30±0,65** 6,98±0,24*** 14,22±0,78*** Oeeoio?ii n-ieneaeaca ( oi. iae / oa o ia a?eea ) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 3,58±0,32 4,35±0,51 10,08±0,41 2,98±0,34 5,56±0,54 8,98±0,26* I?ei?oea. A oe?e ? ianooiieo oaaeeoeyo *,**,*** - a??ia?aei?noue a?aei?iiinoae o cia/aiiyo iieaciee?a i?ae aeine?aeiith ? eiio?ieueiith a?oiaie oaa?ei (*- ?F0,05; **- ?F0,01; ***- ?F0,001). A i?ioean? aeine?aeaeaiue anoaiiaeaii, ui e??i aia?aaoe/iiai iai?io, ?ioith /ooeeaith aei aieeao a?ae?iei?oeciio ae?eyieith iaoaaie?cio a eaeeioeeoao ? i??ei?aeieo ee?oe-iao e?noeiaiai iiceo ? i?ioaie?oe/ia nenoaia. I?e oeueiio aeyaeaii, ui ae?y ai?iiio ? iaiaeiicia/iith a?aeiinii ooieoe?iiaeueii? caeaoiino? iaeo?aeueieo ? eeneeo i?ioa?iac (oaae.2). Oae i?ney ?i'?eoe?e ai?iiio aeoeai?noue eaeia?i?a cieaeo?oueny a on?o aeine?aeaeo-aaieo ee?oeiao, a eaoainei?a - c?inoa? a a?aioeioeeoao ? e?ioioeeoao e?ia? oaa?ei. Oaaeeoey 2 - Aieea a?ae?iei?oeciio ia aeoeai?noue i?ioaie?oe/ieo oa?iaio?a a i??eiea??ioeeoao ? eaeeioeeoao e?ia? naeiae (I±m; n=5) A?oie oaa?ei Ee?oeie Eiio?ieue Aeine?ae Eaoaineie (ia noano?aoo / oa o ia a?eea) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 12,84±1,50 4,20±0,31 3,00±0,15 14,1±1,08 6,93±0,72** 8,60±1,10*** Eaeia?ie (ia noano?aoo / oa o ia a?eea) I??eiea??ioeeoe Iaeo?io?ee E?ioioeeoe 15,60±0,91 10,28±0,79 13,51±0,76 11,58±1,30* 6,95±0,87* 5,25±0,56*** Oaeei /eiii aenia?eiaioaeueii anoaiiaeaii o/anoue a?ae?iei?oeciio a ?aaoeyoe?? ie?aieo eaiie iaoaaie?cio a eaeeioeeoao ? ?o iiia?aaeieeao a e?noeiaiio iiceo ii?inyo. I?ney o?eaaeiai aaaaeaiiy ai?iiio a i??eiea??ioeeoao, iaeo?io?eao ? e?ioioeeoao cieaeo?oueny ?ioaineai?noue ii/aoeiaeo noaae?e ae?eie?co ? iaioicioinoaoiiai oeyoo oa i?eai?/o?oueny aeoeai?noue i?oioiiae??aeueii? oeeoio?ii n-ieneaeace. ?acii c oei a ee?oeiao aeine?aeaeoaaieo iiioeyoe?e cieaeo?oueny aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie. Oae? aoaeoe a?ae?iei?oeciio cia/iith i??ith coiiaeththoue i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? eaeeioeeo?a oa ?ioiieo ?aaeoe?e a i?aai?ci? oaa?ei a iaiiaoaeueiiio ia??iae? ?icaeoeo [Iayineee Ae.I., Iaea?iaa I.I.,1989; Meier C. A., 1996], a c aenieei ai?noii aetheiei?oeei?ae?a o e?ia? iiaiia?iaeaeaieo, i/aaeaeii, ca'ycaia iecueea ?ioaineai?noue i??ei- ? e?ioioeeoiiiaco o nnaaoe?a i?e ia?aoiae? a?ae i?a- aei iinoiaoaeueiiai iioiaaiaco. Aieea ?ii?a cae?ca ? naeaio ia iaoaaie?ci a eaeeioeeoao ? i??ei?aeieo ee?oeiao e?noeiaiai iiceo naeiae a ?aiiueiio iinoiaoaeueiiio ia??iae?. Aaeaeaaoia caaacia/aiiy oaa?ei ?aiiueiai a?eo i?ia?aeueieie ?a/iaeiaie, cie?aia, ?iia-ie cae?ca ? naeaio, ia? aaaeeeaa cia/aiiy aeey oi?ioaaiiy a i?aai?ci? aaeaioaoe?eieo iaoai?ci?a oa i?aeo?eiaiiy ee?oeiiiai aiiainoaco [Burgio G.R., 1987, Schrauzer G.N., 1991; Aioiiye A.E., 1997]. Anoaiiaeaii, ui canoinoaaiiy cae?ciaeaeno?aiiaiai i?aia?aoo “Aeaeno?ioa?-100” i?eaiaeeoue aei ?ioaineo?eaoe?? aa?iaieo i?ioean?a aia?aaoe/iiai iai?io. O eaeeioeeoao ii?inyo i?aeaeuo?oueny aeoeai?noue oeeoio?ii n-ieneaeace oa ?cioeeo?aoaeaa?ae-?iaaiace, i?ioa, cieaeo?oueny aeoeai?noue oa?iaio?a ae?eie?co (oaae. 3). ?acii c oei o an?o aeine?aeaeoaaieo oeiao ee?oei ii?inyo 1-? aeine?aeii? a?oie i?aeaeuo?oueny eaoae?oe/ia aeoeai?noue aetheici-6-oinoaoaeaa?ae?iaaiace (aeea. oaae. 3). Oaaeeoey 3 - Aieea aeaeno?ioa?o ? naeai?oo iao?ith ia aeoeai?noue oa?iaio?a a e?ioioeeoao ii?inyo (M±m, n=5) Oa?iaio Oiiae aeine?aeaeaiue Aaenie?iaca (iiieue NADI /oa o ia a?eea) Oinoio?oe-oie?iaca (iiieue NAD+ /oa o ia a?eea) Aetheici-6-oinoaoaea-a?ae?iaaiaca (iiieue NADI /oa o ia a?eea) NADP+- ?cioeeo?aoaea- a?ae?iaaiaca (iiieueNADPI/oa o iaa?eea) Oeeoio?ii n-ieneaeaca (oi. iae. / oa o ia a?eea) 3-aeaii? E 9,50±0,78 233±10,5 7,96±0,48 8,03±0,55 7,50±0,92 Ae1 4,88±0,39*** 133 ±11,9 14,1±1,5** 9,47±0,12* 13,96±1,10*** Ae2 8,03±0,72 143±11,5 19,2±1,7*** 7,12±0,85 10,71±1,50 5-aeaii? E 7,53±0,45 357±14,8 11,2±2,2 7,45±0,26 15,14±0,73 Ae1 8,50±1,2*** 306±27,6 18,6±1,67* 8,68±0,48* 15,90±1,12 Ae2 10,02±1,1 385±36,3 19,3±2,12* 8,51±1,32* 11,08±1,33* 10-aeaii? E 10,23±0,9 282±18,3 7,45±0,38 9,42±0,60 10,08±0,71 Ae1 9,82±1,17 223±29,1 10,9±1,3 9,82±0,78 9,28±0,57 Ae2 16,10±1,4** 320±21,5 29,3±1,8*** 10,2±1,2 14,72±1,20* Aeoeaaoe?y ieenieo i?ioean?a o ee?oeiao, ye a?aeiii, aaaea aei ?ioaineo?eaoe?? ooai?aiiy ?aaeoe?eiicaeaoieo oi?i eeniaaeo iieaeoe. Aeoeaaoe?y ia?aeeniiai ieeneaiiy e?i?ae?a, yea coiiaeaia aaaaeaiiyi cae?ciaeaeno?aiiaiai i?aia?aoo, i?eaiaeeoue aei cieaeaiiy a eaeeioeeoao aeoeaiino? oa?iaio?a aioeieneaeaioii? nenoaie - noia?ieneaeaeeniooace ? aeooao?iiia?ieneaeace (oaae. 4). I?ioa ne?ae a?aei?oeoe, ui aeoea-i?noue aeooao?ii?aaeoeoace o eaeeioeeoao oaa?ei 1-? aeine?aeii? a?oie a ie?ai? oa?i?ie aenia?eiaioo c?inoa? (aeea. oaae. 4), ui i/aaeaeii, coiiaeth?oueny i?aeaeuaiiyi ai?noo a ee?oeiao NADPH, o ca'yceo c aeoeaaoe??th a oeae ia??iae oa?iaio?a iaioici-oinoaoiiai ooioo. C iaoith i?aeaeuaiiy aoaeoeaiino? cae?ciaeaeno?aiiaeo i?aia?ao?a o ieai? noeioeyoe?? ooieoe?iiaeueii? aeoeaiino? ?ioiieiiiaoaioieo ee?oei aaaeeeaa cia/aiiy ia? eiiieaenia canoinoaaiiy i?aia?ao?a cae?ca ? aioeieneaeaio?a. Aenia?eiaioaeueii anoaiiaeaii, ui canoinoaaiiy cae?ciaeaeno?aiiaiai i?aia?aoo o eiiieaen? c naeai?-oii iao??th o eaeeioeeoao i?eaiaeeoue aei ii?iae?caoe??, a a ie?ai? oa?i?ie aenia?eiaioo aei c?inoaiiy aeoeaiino? aaenie?iace, oinoio?oeoie?iace ? aetheici-6-oin-oaoaeaa?ae?iaaiace (aeea.oaae. 3). ?acii c oei, aaaaeaiiy naeai?oo iao??th a cia/i?e i??? ni?ey? i?aeaeuaiith ooieoe?iiaeueii? aeoeaiino? noia?ieneaeaeeniooace ? aeooao?ii-ia?ieneaeace oa ii?iae?caoe?? aeooao?ii?aaeoeoace (aeea.oaae. 4). Io?eiai? ?acoeueoaoe aeathoue i?aenoaao aaaaeaoe, ui o/anoue naeaio a ?aaoeyoe?? eaoae?oe/ii? caeaoiino? oa?iaioieo aioeieneaeaio?a a cia/i?e i??? ni?ey? noaa?e?caoe?? ieaciaoe/ieo ? aioo??o-iueiee?oeiieo iaia?ai eaeeioeeo?a ?, a?aeiia?aeii, a?ae?a?a? aaaeeeao ?ieue o caaacia/aii? ooieoe?iiaeueii? aeoeaiino? ee?oei a oiiaao aeoeaaoe?? ieenieo i?ioean?a. Oaaeeoey 4 - Aieea aeaeno?ioa?o ? naeai?oo iao?ith ia aeoeai?noue aioeieneaeaio-ieo oa?iaio?a a iaeo?io?eueieo a?aioeioeeoao ii?inyo (M±m, n=5) Oa?iaio Oiiae aeine?aeaeaiue Noia?ieneaeaeenio-oaca ( oi.iae / oa o ia a?eea ) Aeooao?iiia?iene-aeaca ( iiieue ieeneaiiai aeooao?iio / oa o ia a?eea ) Aeooao?ii?aaeoeoaca ( iiieue NADP+ / oa o ia a?eea) 3-aeaii? E 12,76±0,91 18,80±0,75 15,42±1,12 Ae1 12,18±0,57 17,16±1,12 23,00±1,29*** Ae2 13,73±1,65 21,95±0,96* 20,82±0,70*** 5-aeaii? E 12,82±1,10 21,45±1,47 21,58±2,05 Ae1 8,58±0,95* 23,66±2,45 23,40±2,61 Ae2 13,84±0,82 24,68±2,60 22,79±2,16 10-aeaii? E 13,30±0,65 19,45±1,16 18,02±1,92 Ae1 10,78±0,74* 10,82±0,48*** 16,78±1,39 Ae2 12,85±1,20 26,42±1,85** 16,84±1,13 Oaeei /eiii, aioo??oiueiee?oeii? iaoaaie?/i? aoaeoe ?ii?a cae?ca ? naeaio noai?ththoue oiiae aeey noaiiaeaiiy caoenii? ooieoe?? eaeeioeeo?a oaa?ei, i?aeaeuaiiy ?ioiii? ?aaeoeaiino? oa aaeaioaoe?eieo iiaeeeainoae i?aai?cio a ?aiiueiio iinoiaoaeueiiio ia??iae? iioiaaiaco. AENIIAEE 1. Anoaiiaeai? ai?iiiaeueii-noano?aoi? iaoai?cie ?aaoeyoe?? iaoaaie?cio a i??ei?ae-ieo ee?oeiao e?noeiaiai iiceo oa eaeeioeeoao e?ia? naeiae ?aiiueiai a?eo. Iaea?aeai? ?acoeueoaoe iiaeooue aooe oai?aoe/iith iniiaith aeey ?ic?iaee aaeaioiaaiieo oaoiieia?e oa ?ioiiiiaeoeyoi??a c iaoith i?aeaeuaiiy ?acenoaioiino? ? i?io?eae-oeee caoai?thaaiue iiaiia?iaeaeaieo oaa?ei. 2. A ia??iae? a?ae ia?iaeaeaiiy aei 10-aeiaiaiai a?eo a e?noeiaiio iiceo naeiae a?aeao-aa?oueny ?ioaineo?eaoe?y i?ioean?a i??ei- oa e?ioioeeoiiiaco. O ia?eoa??ei?e e?ia? 10-aeiaiaeo oaa?ei aaea?/? c?inoa? ai?no e?ioioeeo?a ( P<0,001 ). 3. A i??ei?aeieo ee?oeiao e?noeiaiai iiceo ? eaeeioeeoao e?ia? naeiae i?ney ia?iaeaeaiiy i?aeaeuo?oueny aeoeai?noue ie?aieo oa?iaio?a ae?eie?co, cie?aia, a i??eiea??ioeeoao 3-aeiaiaeo ii?inyo aeoeai?noue aaenie?iace c?inoa? a 1,3 ?ace (P<0,05), i??oaaoe?iace - a 1,2 ?ace (P<0,05) o ii??aiyii? c aeoeai?noth oa?iaio?a a iiaiia?iaeaeaieo oaa?ei. O 3-aeiaiaeo ii?inyo aeoeai?noue aetheici-6-oinoao-aeaa?ae?iaaiace i?aeaeuo?oueny a i??eiea??ioeeoao a 1,6 ?ac?a (P<0,05), a iaeo?io?eueieo a?aioeioeeoao - a 1,2 ?ace (P<0,05), a a e?ioioeeoao - a 3 ?ace (P<0,001). Aeoeai?noue oeeoio?ii n-ieneaeace o e?ioioeeoao ia 3-th aeiao aeeooy c?inoa? iaeaea a 5 ?ac?a (P<0,001). 4. A ?aiiueiio ia??iae? iinoiaoaeueiiai iioiaaiaco a i??ei?aeieo ee?oeiao e?noeiaiai iiceo oa eaeeioeeoao e?ia? naeiae niinoa??aa?oueny aeoeaaoe?y oa?iaio?a aioeieneaeaioii? nenoaie, cie?aia, a iaeo?io?eueieo a?aioeioeeoao 3-aeiaiaeo ii?inyo aeoeai?noue noia?ieneaeaeeniooace c?inoa? a 7,7 ?ace (P<0,001), aeoeai?noue aeooa-o?iiia?ieneaeace - a 3,2 ?ace (P<0,001), a aeooao?ii?aaeoeoace - 1,4 ?ace (P<0,001). 5. I?ioyaii ?aiiueiai iinoiaoaeueiiai ia??iaeo a ee?oeiao e?noeiaiai iiceo ? eaeeioeeoao ii?inyo a?aeaoaathoueny ci?ie aeoeaiino? i?ioaie?oe/ieo oa?iaio?a, a naia, aeoeai?noue eaoainei?a o i??eiea??ioeeoao 10-aeiaiaeo oaa?ei c?inoa? a 4 ?ace (P<0,001), a iaeo?io?eueieo a?aioeioeeoao - a 2 ?ace (P<0,01), aeoeai?noue eaeia?i?a a i??eiea??ioeeoao c?inoa? a 3 ?ace (P<0,001), a a iaeo?io?eueieo a?aioeioeeoao - a 1,2 ?ace (P<0,05). 6. I?ney o?eaaeiai aaaeaiiy a?ae?iei?oeciio cieaeo?oueny ?ioaineai?noue a?aioeioeeoiiiaco, a a eaeeioeeoao ? ee?oeiao e?noeiaiai iiceo ii?inyo a?aeaoaa?oueny ia?aaoaeiaa ie?aieo eaiie aia?aaoe/iiai iaoaaie?cio. A i??eiea??ioeeoao ? iaeo?io?eueieo a?aioeioeeoao aeoeai?noue aaenie?iace cieaeo?oueny a?aeiia?aeii ia 32 % (P<0,001) ? 20 % ( P<0,01), aetheici-6-oinoaoaeaa?ae?iaaiace ia 57 % ? 70 % (P<0,001). O an?o oeiao ee?oei i?aeaeuo?oueny aeoeai?noue i??oaaoe?iace ( P<0,001 ). A e?ioioeeoao oaa?ei ciaioo?oueny aeoeai?noue oeeoio?ii n-ieneaeace (P<0,05 ). 7. I?ae aieeaii a?ae?iei?oeciio a ee?oeiao e?noeiaiai iiceo ? eaeeioeeoao cieaeo?oueny aeoeai?noue oa?iaio?a aeooao?iiiai? neoaie ? noia?ieneaeaeeniooace (P<0,05-0,001). O eaeeioeeoao e?ia? i?ae aieeaii ai?iiio ci?ith?oueny aeoeai?noue oa?iaio?a i?ioaie?co, cie?aia, cieaeo?oueny aeoeai?noue eaeia?i?a a 1,5-2,5 ?ace oa c?inoa? aeoeai?noue eaoainei?a a 1,6-2,8 ?ace (P<0,05-0,001). 8. I?ney aaaaeaiiy cae?ciaeaeno?aiiaiai i?aia?aoo “Aeaeno?ioa?-100” o eaeeioeeoao naeiae a?aeaoaa?oueny aeoeaaoe?y aa?iaieo i?ioean?a aia?aaoe/iiai iai?io oa cie-aeaiiy aeoeaiino? oa?iaio?a aioeieneaeaioii? nenoaie - noia?ieeaeaeeniooace ? aeooao?iiia?ieneaeace. I?e canoinoaaii? cae?ciaeaeno?aiiaiai i?aia?aoo o eiii-eaen? c naeai?oii iao??th a eaeeioeeoao naeiae i?aeaeuo?oueny aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie oa ii?iae?co?oueny ?ioaineai?noue aia?aaoe/ieo i?ioean?a. I?iiiceoe?? ae?iaieoeoao. Ii?inyoai i?ioyaii ia?oeo 10-oe ae?a aeeooy c iaoith i?aeaeuaiiy ?ioiii? ?aaeoeaiino? i?aai?cio, ??aiy caa?aaeaiiy oa ?ioaineo?eaoe?? ?inoo oaa?ei i?ioyaii e?eoe/iiai ia??iaeo iioiaaiaco ? i?io?eaeoeee ieneaeaoe?eiiai no?ano ?aeiiaiaeo-?oueny ii?aeiaia aioo??oiueii'yciaa aaaaeaiiy a 2-aeiaiaiio a?oe? naeai?oo iao??th (a aeic? 0, 075 ia naeaio / ea iane o?ea), a ia 3-th aeiao aeeooy – aeaeno?ioa?o (c ?ic?a-ooieo 1,5 – 2 ia / ea iane o?ea). NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. ?ne?a ?.ss., Aeai/oe I.I., Aioiiye A.E., Ni?oeinueeee A.A., Eoooa ?.A. Ci?ie aeoeaiino? oa?iaio?a aia?aaoe/iiai iai?io oa aioeieneaeaioii? nenoaie a eaeeioeeoao ? ee?oeiao e?noeiaiai iiceo naeiae a ?aiiueiio iinoiaoaeueiiio ia??iae? // Iaoe. - oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1997. - Aei. 19 (1). - N.8-11. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueieo aeine?aeaeaiue, aiae?c ? ocaaaeueiaiiy ?acoeueoao?a oa iaienaiiy i?aoe?). 2. Aioiiye A.E., ?ne?a ?.ss., Ni?oeinueeee A.A., Ni?oeinueea ?.A., Aioiiye I.I. A?eia? ci?ie aeoeaiino? aeaa?ae?iaaiac a eaeeioeeoao oa ?o iiia?aaeieeao o e?noeiaiio iiceo naeiae // Iaoe.- oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1996. - Aei. 18 (1). - N. 20-23. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueieo aeine?aeaeaiue, noaoenoe/ia ia?iaea, aiae?c oa ocaaaeueiaiiy iaea?aeaieo ?acoeueoao?a). 3. Aioiiye A.E., Ni?oeinueeee A.A., Aaae/ I.I., ?ne?a ?.ss., Ao/ei I.I. ?ieue naeaio a ?aaoeyoe?? ooieoe?iiaeueii? aeoeaiino? eaeeioeeo?a e?ia? oaa?ei o iaiiaoaeueiiio ia??iae? // A?niee aa?a?ii? iaoee. - 1999. - ? 5. - N. 36-38. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueieo aeine?aeaeaiue, noaoenoe/ia oa aiae?oe/ia ia?iaea iaea?aeaieo ?acoeueoao?a). 4. ?ne?a ?.ss., Aioiiye A.E., Ni?oeinueeee A.A. Aieea ei?oecieo ia ai?no iiioeyoe?e i??ei?aeieo ee?oei e?noeiaiai iiceo ? eaeeioeeo?a ii?inyo // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1998. - ?16 - N. 45-47. (Caeiaoaa/o iaeaaeeoue i?iaaaeaiiy oeeoieia?/ieo aeine?aeaeaiue, aiae?c ?acoeueoao?a oa iaienaiiy i?aoe?). 5. Aioiiye A.E., Ni?oeinueeee A.A., ?ne?a ?.ss., Aaae/ I.I. Aeeiai?ea aeoeaiino? oa?iaio?a aia?aaoe/iiai iaoaaie?cio a i??ei?aeieo ee?oeiao ? eaeeioeeoao naeiae o iaiiaoaeueiiio ia??iae? // Iaaee/ia o?i?y. - 1999. - ?1 - N. 52-56. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueii? /anoeie, noaoenoe/ia oa aiae?oe/ia ia?iaea ?acoeueoao?a). 6. Aioiiye A.E., Ni?oeinueeee A.A., Aa?oaaenueeee A.?., ?ne?a ?.ss., Aaeueeianueeee A.A., Eoooa ?.A. Oa?aeoa?enoeea ie?aieo eaiie iaoaaie?cio aetheice a ee?oeiao e?noeiaiai iiceo naeiae a ?aiiueiio ia??iae? iinoiaoaeueiiai ?icaeoeo // Iaoe.- oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1997. - Aei. 19 (1). - N.16-19. (Caeiaoaa/ aeeiiaea aenia?eiaioaeueio /anoeio, noaoenoe/io ia?iaeo ?acoeueoao?a oa ?o aiae?c). 7. Aioiiye A.E., Ni?oeinueeee A.A., Aa?oaaenueeee A.?., ?ne?a ?.ss., Aaeueeianueeee A.A. Ci?ie iiioeyoe?eiiai neeaaeo a?eo?i?aeieo ee?oei e?noeiaiai iiceo ? e?ia? naeiae a iaiiaoaeueiee ia??iae ?icaeoeo // Iaoe.- oaoi. atheaoaiue ?inoeoooo o?c?ieia?? ? a?io?i?? oaa?ei. - 1996. - Aei. 18 (1). - N. 14-17. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy oeeoieia?/ieo aeine?aeaeaiue, noaoenoe/ia oa aiae?oe/ia ia?iaea iaea?aeaieo ?acoeueoao?a). 8. Aioiiye A.E., Ni?oeinueeee A.A., Aeai/oe A.A., Aaae/ I.I., ?ne?a ?.ss., Aaeueeianueeee A.A., E?aeooi A.A., Ao/ei I.I. Aieea aeciaaiieo ai?iii?a ia ooie-oe?iiaeueio aeoeai?noue aiaeie?eiieo caeic ii?inyo o iaiiaoaeueiiio ia??iae? iioiaaiaco // A?niee A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo. - 1998. - Aei.5, /ano.1. - N. 150-153. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy /anoeie aenia?eiaioaeueieo aeine?aeaeaiue, noaoenoe/ia ia?iaea ?acoeueoao?a oa aiae?c ? ?ioa?i?aoaoe?y ?acoeueoao?a). 9. ?ne?a ?.ss., Aioiiye A.E., Ao/ei I.I. Aaeueeianueeee A.A., ?aiaoaiei TH.A., Ni?oeinueeee A.A. Aieea i?e?iaeaiaio?a ia aeaye? eaiee iaoaaie?cio a i??ei?aeieo ee?oeiao oaa?ei // Iaoeiaee a?niee Iaoe?iiaeueiiai aa?a?iiai oi?aa?neoaoo. - 1998. - ?12. - N. 112-115. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueieo aeine?aeaeaiue, noaoenoe/ia ia?iaea oa aiae?c iaea?aeaieo ?acoeueoao?a). 10.Aioiiye A.E., ?ne?a ?.ss., Ao/ei I.I., Ni?oeinueeee A.A. ?ieue naeaio a ?aaoeyoe?? iaoaaie?cio a ?ioiieiiiaoaioieo ee?oeiao naeiae oaa?ei // Iaoeiaee a?niee Iaoe?iiaeueiiai aa?a?iiai oi?aa?neoaoo. -1998. - ?12. - N. 109-112. (Caeiaoaa/o iaeaaeeoue aeeiiaiiy aenia?eiaioaeueieo aeine?aeaeaiue oa aiae?c iaea?aeaieo ?acoeueoao?a). 11.Ni?oeinueeee A.A., Aioiiye A.E., ?ne?a ?.ss., Ao/ei I.I., E?aeooi A.A., Aeai/oe A.A., Aaeueeianueeee A.A. Aeaeia? iniaeeaino? ai?iiiaeueiiai noaoono aaeeei? ?iaaoi? ooaeiae ? naeiae a ia??iae iaiiaoaeueii? aaeaioaoe?? / Iaoa??aee OV c'?caeo oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa. – Aeiiaoeuee. - 1998 / O?c?ieia?/iee aeo?iae. – 1998. – O. 44, ? 3. – N. 239. 12.?ne?a ?.ss. Aeoeai?noue oa?iaio?a aia?aaoe/iiai iai?io a eaeeioeeoao e?ia? ? ee?oeiao e?noeiaiai iiceo naeiae a iaiiaoaeueiee ia??iae // I?aoe? VII oe?a?inueeiai a?io?i?/iiai c'?caeo. - Ee?a. - 1997. – N. 17-18. 13.Snitinsky V.V., Antoniak H.L., Iskra R.Y. The role monodeiodine processes in mechanims of mechanisms of influence of thyreoid hormones upon metabolism in cells // Abstrakty “Dni fyziologie hospodarskych zvierat”. XVII. – Kosice (Slovenska Republika ). – 1997. – C. 65. 14.Aioiiye A.E., Aa?oaaenueeee A.I., Aeai/oe I.I., Ine?a ?.ss., Niioeinueeee A.A. Ai?iiiaeueia ?aaoeyoeiy iaoaaie?/ii? aeoeaiino? a a?eo?ioeeoao naeiae a iaiia-oaeueiiio ia??iae? // I?aoe? I Oe?a?inueeiai neiiic?oio ii aiaeie?eiieia?? oaa?ei. - Euea?a. - 1994. - N. 7-8. 15.Nieoeinueeee A.A., Aioiiye A.E., Ene?a ?.ss., Aeai/oe I.I. Ai?iiiaeueiay ?aaoeyoeey iaoaaiee/aneie aeoeaiinoe a eeaoeao e?iae e einoiiai iicaa naeiae // O?oaeu aoi?ie iaaeaeoia?iaeiie eiioa?aioeee “ Aeooaeueiua i?iaeaiu aeieiaee a aeeaioiiaiaenoaa”. - Ai?iane. - 1995. – N. 159. 16.Aioiiye A.E., Ni?oeinueeee A.A., Ee/oi ?.A., ?ne?a ?.ss. A?eia? iniaeeaino? i?ioeano ca'ycoaaiiy 125?-?inoe?io a?eo?i?aeieie ee?oeiaie e?ia? naeiae // Aenia?eiaioaeueia ? ee?i?/ia o?c?ieia?y. Ca??iee iaoeiaeo i?aoeue aei 100-??//y eaoaae?e o?c?ieia?? Euea?anueeiai iaaee/iiai oi?aa?neoaoo. Euea?a. - 1995. - N. 89-90. 17.Aeai/oe A.A., ?ne?a ?.ss., Aeai/oe I.I. Iaoaaie?ci a a?eo?ioeeoao naeiae a ?aii?e ia??iae i?ney ia?iaeaeaiiy // I?aoe? i?aeia?iaeiiai neiiic?oio “ A?ieia?/i? iaoai?cie noa??iiy”. – Oa?e?a. - 1996. - 44 n. 18.?ne?a ?.ss. A?eia? ci?ie aeoeaiino? aeaa?ae?iaaiac o ee?oeiao e?ia? ? e?noei-aiai iiceo naeiae a iaiiaoaeueiee ia??iae // I?aoe? i?aeia?iaeii? iaoeiai - i?aeoe/ii? eiioa?aioe?? iieiaeeo a/aieo “ Iaoeia? aeinyaiaiiy a aaeoc? aaoa?eia?ii? iaaeeoeeie ” – Oa?e?a. – 1997. – N. 93-95. 19.Aioiiye A.E., Ni?oeinueeee A.A., ?ne?a ?.ss., Ao/ei I.I., Aaeueeianueeee A.A. Aeaye? iieacieee iaoaaie?cio a eaeeioeeoao oa ee?oeiao e?noeiaiai iiceo naeiae a ia??iae? iinoiaoaeueii? aaeaioaoe?? // I?aoe? ??? i?aeia?iaeiiai neiiic?oio “ A?ieia?/i? iaoai?cie noa??iiy ”. – Oa?e?a. – 1998. – N. 84. 20.Ni?oeinueeee A.A., Aioiiye A.E., E?aeooi A.A., ?ne?a ?.ss., Ao/ei I.I., Aaeueeianueeee A.A. Aeaye? aniaeoe i?ia?aeueiiai aeeaeaiiy oaa?ei o iaiiaoaeueiiio ia??iae? // I?aoe? i?aeia?iaeii? eiioa?aioe?? “ A?ieia?/i? iniiae aeeaeaiiy n?euenueei-ainiiaea?nueeeo oaa?ei ”. - Euea?a. - 1998. - N.21. ?ne?a ?.ss. Ai?iiiaeueii-noano?aoi? iaoai?cie ?aaoeyoe?? aoaeaaiaeiiai iai?io oa aioeieneaeaioii? nenoaie a i??ei?aeieo ee?oeiao ? eaeeioeeoao naeiae ?aiiueiai a?eo. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa n?euenueeiainiiaea?nueeeo iaoe ca niaoe?aeuei?noth 03.00.04 - a?io?i?y. - ?inoeooo caiea?ianoaa ? a?ieia?? oaa?ei OAAI, Euea?a, 1999. Aeena?oaoe?y i?enay/aia aeine?aeaeaiith a?eiaeo ci?i a eaeeioeeoiiiac? ? iaoaai-e?ci? i??ei?aeieo ee?oei e?noeiaiai iiceo oa eaeeioeeo?a e?ia? naeiae a ?aiiueiio ia??iae? iinoiaoaeueiiai iioiaaiaco. Anoaiiaeaii, ui a?ae ia?iaeaeaiiy aei 10-aeiaiaiai a?eo a e?iaioai?ieo i?aaiao oaa?ei ?ioaineo?eothoueny i?ioeane i??ei- ? e?ioioeeoiiiaco. I?ioyaii ?aiiueiai iinoiaoaeueiiai ia??iaeo a e?ioioeeoao a?aeao-aa?oueny aeoeaaoe?y oa?iaio?a iaioicioinoaoiiai oeyoo oa i?oioiiae??aeueieo oeeoio?ii?a, o iaeo?io?eueieo a?aioeioeeoao niinoa??aa?oueny i?aeaeuaiiy aeoeaiino? oa?iaio?a ie?aieo eaiie ae?eie?co. A i?ioean? iinoiaoaeueii? aaeaioaoe?? a ee?oeiao nenoaie aaiiiiaco ?ioaineo?eothoueny i?ioaie?oe/i? oa?iaioe, a?aeaoaa?oueny noaiiaeaiiy aioeieneaeaioiiai noaoono ee?oei e?noeiaiai iiceo ? eaeeioeeo?a ii?inyo. Anoaiiaeaii, ui ia ?aaoeyoe?th ?ioaineaiino? eaeeioeeoiiiaco ? iaoaaie?cio i?aei?aeieo ee?oei oa eaeeioeeo?a aieeaathoue a?ae?iei?oecii oa i?e?iaeaiaioe (Fe ? Se). Aaaaeaiiy a?ae?iei?oeciio o aenieeo aeicao i?eaiaeeoue aei i?eai?/aiiy ?ioainea-iino? a?aioeioeeoiiiaco, cieaeaiiy aeoeaiino? oa?iaio?a, ui eaoae?cothoue ii/aoeia? noaae?? ae?eie?co ? iaioicioinoaoiiai oeyoo oa i?eai?/aiiy aeoeaiino? oa?iaio?a aioeieneaeaioii? nenoaie a i??ei?aeieo ee?oeiao e?noeiaiai iiceo ? eaeeioeeoao ii?inyo. Canoinoaaiiy cae?ciaeaeno?aiiaeo i?aia?ao?a o eiiieaen? ?c niieoeaie naeaio aaaea aei i?aeaeuaiiy ooieoe?iiaeueii? aeoeaiino? nenoaie aioeieneaeaioiiai caoenoo oa ii?iae?caoe?? aia?aaoe/ieo i?ioean?a o oaaioeeooth/eo oa ?ioiieiiiaoaioieo ee?-oeiao oaa?ei. Eeth/ia? neiaa: naei?, aaeaioaoe?y, i??ei?aei? ee?oeie, iaeo?io?euei? a?aioeioeeoe, e?ioioeeoe, a?ae?iei?oecii, cae?ci, naeai, aia?aaoe/iee iai?i, aioeieneaeaioia nenoaia. Ene?a ?.ss. Ai?iiiaeueii-noano?aoiua iaoaieciu ?aaoeyoeee oaeaaiaeiiai iaiaia e aioeieneaeaioiie nenoaiu a ieaeieaeiuo eeaoeao e eaeeioeeoao naeiae ?aiiaai aic-?anoa. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa naeueneioicyenoaaiiuo iaoe ii niaoeeaeueiinoe 03.00.04 - aeioeiey. - Einoeooo caieaaeaeey e aeieiaee aeeaioiuo OAAI, Eueaia, 1999. Aeenna?oaoeey iinayuaia aii?inai aic?anoiuo iniaaiiinoae eaeeioeeoiiiyca e iaoaaieecia ieaeieaeiuo eeaoie e eaeeioeeoia naeiae a ?aiiai ia?eiaea iinoiaoaeueiiai iioiaaiaca, eco/aieth aeeyiey aeae?iei?oeciia e niaaeeiaiee naeaia ia ieaeiiiyc e iaoaaieeci eaeeioeeoia aeeaioiuo. Onoaiiaeaii, /oi a ia?eiaea io ?iaeaeaiey aei 10-nooi/iiai aic?anoa iinoaiaiii eioaineoeoee?othony i?ioeannu ieaei- e eeioioeeoiiiyca. Ia i?ioyaeaieee ?aiiaai iinoiaoaeueiiai ia?eiaea ?acaeoey a eeioioeeoao aeoeae?othony oa?iaiou iaioicioinoaoiiai iooe e iiauoaaony aeoeaiinoue ieoioiiae?eaeueiuo oeeoi-o?iiia, a iaeo?ioeeueiuo a?aioeioeeoao oaaee/eaaaony eaoaeeoe/aneay aeoeaiinoue iaeioi?uo oa?iaioia aeeeieeca. A i?ioeanna iinoiaoaeueiie aaeaioaoeee aeoeae?othony i?ioaieeoe/aneea i?ioeanu a eeaoeao nenoaiu eaeeioeeoiiiyca e i?ienoiaeeo noaiiaeaiea aioeieneaeaioiiai noaoona ieaeieaeiuo eeaoie einoiiai iicaa e eaeeioeeoia ii?inyo. Onoaiiaeaii, /oi aeae?iei?oecii, eiioeaio?aoeey eioi?iai aeinoeaaao aunieiai o?iaiy a ieacia iiai?iaeaeaiiuo naeiae, i?eieiaao o/anoea a ?aaoeyoeee a?aioeioeeoiiiyca e iaoaaieecia a eeaoeao ieaeieaeiiai ?yaea e eeioioeeoao. Iinea aaaaeaiey yoiai ai?iiia a aeica 40 ia / ea iannu aeeaioiuo ia i?ioyaeaiee 3-o nooie a aaiiiiyoe/aneie oeaie einoiiai iicaa nieaeaaony ioiineoaeueiia niaea?aeaiea eeaoi/iuo yeaiaioia a?aioeioeeoiiiyca e eeioioeeoia, a eeaoeao ieaeieaeiiai ?yaea e eaeeioeeoia ia?eoa?e/aneie e?iae i?ienoiaeyo eciaiaiey eioaineaiinoe ioaeaeueiuo yoaiia yia?aaoe/aneiai iaiaia e i?ioaieeoe/aneeo i?ioeannia. A /anoiinoe, aeae?iei?oecii nieaeaao nei?inoue oinoi?eee?iaaiey aaenic e aeoeaiinoue aetheici-6-oinoaoaeaaeae?iaaiacu a enneaaeoaiuo eeaoeao, /oi iiaeao iaoneiaeeaaoue nieaeaiea ooieoeeiiaeueiie aeoeaiinoe iaeo?ioeeueiuo a?aioeioeeoia - eo niiniaiinoe e oaaioeeoico e aaeoa?eoeeaeiiio aeaenoaeth. Aianoa n oai iiauoaiea aeoeaiinoe ie?oaaoeeiaciie ?aaeoeee, eioi?ia iaaethaeaaony a eeaoeao einoiiai iicaa e eaeeioeeoao, i?e ieceie nei?inoe ia/aeueiuo noaaeee aeeeieeca iiaeao oeacuaaoue ia aiaea/aiea a i?ioeann aeeeieeoe/aneiai ?anuaieaiey eioa?iaaeeaoia eeieaeiiai eaoaaieecia. Iinea eiueaeoeee aeeaioiui aeae?iei?oeciia a eaeeioeeoao e eeaoeao einoiiai iicaa oaiaoaaony ooieoeeiiaeueiay aeoeaiinoue oa?iaioia aioeieneaeaioiie caueou e nieaeaaony aeoeaiinoue Na2+- caaeneiuo i?ioaeiac (eaeiaeiia). Yoi iiaeao iaoneiaeeaaoue aeanoaaeeecaoeeth iaia?aiiuo no?oeoo? eeaoie, ia?ooaiea ooieoeee ?aoeaioi?ia e nieaeaiea /onoaeoaeueiinoe eeaoie e aeaenoaeth aaiiiiyoe/aneeo oaeoi?ia ?inoa e oaiiao?aeoaioia. Oaeei ia?acii, ?acoeueoaou enneaaeiaaiee oeacuaatho ia oi, /oi aunieee o?i-aaiue aeae?iei?oeciia a i?aaiecia aeeaioiuo i?e ?iaeaeaiee iiaeao a cia/eoaeueiie noaiaie iaoneiaeeaaoue ieceoth eioaineaiinoue eaeeioeeoiiiyca e oaiaoaiea ooieoeeiiaeueiie aeoeaiinoe eeaoie eiioiiie nenoaiu. Onoaiiaeaii, /oi i?eiaiaiea aeaeaciaeaeno?aiiauo i?aia?aoia a eiieaena n niaaeeiaieyie naeaia niinianoaoaoiiauoaieth aeoeaiinoe oa?iaioia aioeieneaeaioiie caueou e ii?iaeecaoeee yia?aaoe/aneeo i?ioeannia. A nayce n yoei iaoaaiee/aneea yooaeou eiiia nicaeatho oneiaey aeey iiauoaiey eioaineaiinoe ?aaeoeee eeaoi/iiai e aoii?aeueiiai eiioieoaoa, niinianoaotho noaiiaeaieth caueoiie ooieoeee e?iae naeiae a ?aiiai iinoiaoaeueiii ia?eiaea ?acaeoey. Eeth/aaua neiaa: naeiuee, aaeaioaoeey, ieaeieaeiua eeaoee, iaeo?ioeeueiua a?aioeioeeou, eeioioeeou, aeae?iei?oecii, aeaeno?ioa?, naeaieo iao?ey, yia?aaoe/aneee iaiai, aioeieneaeaioiay nenoaia. Iskra R.J. Hormonal-substrate mechanisms of regulation of carbohydrate metabolism and antioxidant system in early aged piglets. - Manuscript. Doctoral thesis by speciality 03.00.04 - biochemistry. The Institute of Agriculture and Animal Biology of UAAS, Lviv, 1999. The dissertation is directed on study of the age peculiarities of leukopoiesis and metabolism in myeloid cells and leukocytes in pigs in the neonatal period of development. It has been established that during the period from birth to 10 days of age processes of myelo- and lymphopoesis in animal organism were gradually intensified. During the neonatal period activation of pentosophosphate pathway enzymes and mitochondrial cytochromes in pig on of antioxidant enzymes and provide the changes in several links of energy metabolism. Key words: pig, adaptation, myeloid cells, neutrophilic granulocytes, lymphocytes, cortisol, sodium selenite, dextrofer, energy metabolism, antioxidant system.

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