Aeaaeai?y iaaee/ieo iaoe Oe?a?ie

?inoeooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea

Aia?iaa Ieaia Aieiaeeie??aia

OAeE: 616.12-008.331.1:612

AIIAINOAC IAAIITH I?E ANAIOeIAEUeIIE A?IA?OAICI?

(ee?i?ei-o?c?ieia?/ia oa?aeoa?enoeea, iaoio?c?ieia?y, ai?iiiaeueia
?aaoeyoe?y, ei?aeoe?y ii?ooaiue, iaa?oiooaaiiy aeai?o

aioea?ia?oaiceaii? oa?ai??)

14.01.11 — ea?ae?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII
Oe?a?ie ? Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
I.Ai?ueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe EIEII??OeUe A?eoi??y Aieiaeeie??aia,
Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.Ai?ueeiai IIC
Oe?a?ie, i?ioani? eaoaae?e aioo??oi?o oai?ia ?2).

Io?oe?ei? iiiiaioe:

— Aeieoi? iaaee/ieo iaoe, Aeaaeai?e AII Oe?a?ie, i?ioani? AeCssE Aai?a?e
A?eoi?iae/, Aei?i?iiao?ianueea iaaee/ia aeaaeai?y IIC Oe?a?ie,
caa?aeoaa/ eaoaae?e aini?oaeueii? oa?ai?? ?2.

— Aeieoi? iaaee/ieo iaoe, Aeaaeai?e AII Oe?a?ie, *eai-ei?. IAI Oe?a?ie ?
AII ?in??, i?ioani? EI?EOOEI Ieaa Aaneeueiae/, ?inoeooo aa?iioieia?? AII
Oe?a?ie, ea??aiee a?aeae?eo ee?i?/ii? o?c?ieia?? oa iaoieia?? aioo??oi?o
i?aai?a.

— Aeieoi? iaaee/ieo iaoe, i?ioani? OIEA? Aiaoie?e Aieiaeeie?iae/,
Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i.I.E.Ooieea IIC
Oe?a?ie, caa?aeoaa/ eaoaae?e aa?iioieia?? ? aa??ao???.

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey IIC Oe?a?ie, eaoaae?a oa?ai?? noiiaoieia?/iiai
oaeoeueoaoo (i.Ee?a).

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 14 ” aa?aniy 1999 ?. i “ 12 ”
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01
?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie (252151,
Ee?a, aoe. Ia?iaeiiai Iiie/aiiy, 5)

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie ca aae?anith (252151
Ee?a, aoe. Ia?iaeiiai Iiie/aiiy, 5).

Aaoi?aoa?ao ?ic?neaiee “12” na?iiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Aeaye N.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. A?oa??aeueia a?ia?oaic?y (AA) ? iaeiei c naieo
?iciianthaeaeaieo o na?o? caoai?thaaiue: 15-30 % aei?ineiai ianaeaiiy
iathoue i?aeaeuaiee a?oa??aeueiee oene (AO) [?.I. Naeuaiei 1997; ?.I.
Nie?iiaa ? ni?aaao., 1997, 1998; A.A. Aecye, O.A. Eieaniee, 1998].
Iaoiaaii?noue AA caiaaeoi aeniea — AA ? i?ia?aeiei oaeoi?ii ?eceeo
?oai?/ii? oai?iae na?oey, iiceiaiai ?inoeueoo, na?oeaai? iaaeinoaoiino?,
oiaoi iniiaieo i?e/ei ?iaae?aeiino? ? nia?oiino? [O.TH. Iaea?aae/, 1997;
?.A. Na?a??i?, 1997; A.A. Aecye, O.A. Eieaniee, 1998; ?.I. Nie?iiaa ?
ni?aaao., 1998]. A Oe?a?i? aeniea ?iciianthaeaeai?noue AA na?aae
ianaeaiiy ca inoaii? 5 ?ie?a noi?iaiaeaeo?oueny c?inoaiiyi ia?aeiii?
?iaae?aeiino? aiane?aeie AA iaa?oue o 3 ?ace ? nia?oiino?, iia’ycaiii? c
AA, o 1,7 ?ace. O ca’yceo c oeei i?iaeaia AA ia? nioe?aeueia cia/aiiy ?
? iaoe?iiaeueiith [?.I. Naeuaiei, 1997; ?.I. Nie?iiaa ? ni?aaao., 1997,
1998; A.A. Oiea? ? ni?aaao., 1998]. Ia aeaeue, ia aeeaey/enue ia
iayai?noue aaeeeiai a?naiaeo aioea?ia?oaiceaieo i?aia?ao?a, ?o aea??
caeeoa?oueny a iniiaiiio aii??e/iei, a aoaeoeai?noue aioea?ia?oaiceaii?
oa?iaeioa?ai?? iaaeinoaoiueith, ui iio?aao? ooi/iaiiy ? iaoiaaiaoe/iiai
iaa?oiooaaiiy iieacaiue aeey ?? i?iaaaeaiiy [A.I. Aia?ia, I.E, AEa??iia
1998; A.A. Eieii??oeue ? ni?aaao., 1998].

A?aeiii, ui a a?eueoino? aeiaaee?a a iniia? anaioe?aeueii? a?ia?oaic??
(AA) eaaeeoue i?aeaeuaiiy oiiono aeaaeeeo i’yc?a noaeei. Noaeeiiee oiion
aecia/a?oueny aaeainii i?ae oaeoi?aie ?aeaenaoe?? ? eiino?eeoe??.
Ana?aaeei? aeaaeeii’yciai? ee?oeie noaeeie oa o ea?ae?ii?ioeeo? ?iie
iaai?th aa?ooue o/anoue o ii?aeiaii? i?ioean?a caoaeaeaiiy — nei?i/aiiy
— ?icneaaeaiiy. Aeao?oeeo aioo??oiueiee?oeiiiai iaai?th, ui ? i?e?iaeiei
aioaaii?noii eaeueoe?th, i?eaiaeeoue aei aacieiino?eeoe??, ca yeo ?
a?aeiia?aeaeueiee eaeueoe?e, ? i?aeaeuo? /ooeea?noue a?oa??e aei
aacii?ani??a. [E.N. Nayoia, A.I. Oeeia, 1996; A.L. Tranquilli et al.,
1992; M.J. Picado et al., 1993; ?. Laurant, A. Berthelot, 1994]. O
aeine?aeaeaiiyo B.M. Altura, B.T. Altura et al. (1995), M. Kawai et al.
(1996); Wester ?. (1995) aoei aeiaaaeaii, ui a iaoe??io?a ?c AA
niinoa??aa?oueny cieaeaiiy eiioeaio?aoe?? iaai?th a oeeoiieaci? ee?oei,
ui, o naith /a?ao, aaaea aei i?aeaeuaiiy oiiono noaeei ? i?aeaeuaiiy
??aiy AO. Iaeiae ia ?nio? iaeiicia/ii? aeoiee i?i aieea iaai?th ia
??aaiue AO. Iacaaaeath/e ia yaiee aieea aino?eo ii?ooaiue iaai??i?? ia
??aaiue AO, ca’ycie i?ae ieaciaiiith ? aioo??oiueiee?oeiiith
eiioeaio?aoe??th iaai?th, eiai ae??oe/iei niiaeeaaiiyi ? ie?eiaith
aene?aoe??th c iaei??? noi?iie ? ??aiai AO, c ?ioi? iaaaaaoi iaioa
ae?aciee ? i?inoaaeo?oueny ia caaaeaee. Ia?i?aeueiee i?eeii iaai?th a
aeic? 15 ? 20 iiieue/24 aiaeeie ia aeyaeya aeiaeaoeiaiai a?iioaiceaiiai
aoaeoo [E. Miyagawa et al.,1992]. Aeyaeai? i?e AA ??ci? ci?ie iieaciee?a
iaoaaie?cio iaai?th iaea?aeothoue ??cia o?aeooaaiiy ? ia ae?iaeaii
?aeeiiai oyaeaiiy i?i oa, /e iathoue aiie iaoio?c?ieia?/ia cia/aiiy a
?icaeoeo AA ?, ioaea, ?oiy ei?aeoe?y iiaea ni?eyoe ia?aeii?e ? aoi?eii?e
i?io?eaeoeoe? aai aiie i?inoi noi?iaiaeaeothoue i?aeaeuaiiy AO ? ia
aeiaaathoue ei?aeoe??. Ii?ooaiiyi iaoaaie?cio iaai?th a iaoiaaiac? AA
i?eae?ey?oueny iacaneoaeaii iaea ?ieue, ui caiaeeoueny, a iniiaiiio,
o?eueee aei o/ano? ?ii?a iaai?th o aioo??oiueiee?oeiieo i?ioeanao
nei?i/aiiy aeaaeeeo i’yc?a noaeei. Iaaiee ai?no iaai?th ona?aaeei?
ee?oei caaacia/o?oueny ceaaiaeaeaiei ooieoe?eiioaaiiyi on?o eaiie
iaoaaie?cio iaai?th (eeoeiaa aani?aoe?y, ie?eiaa aene?aoe?y, o?ainii?o
iaai?th iii?ae iicaee?oeiiith ??aeeiith, e?noeaie ? ee?oeiaie). Noai
iaoaaie?cio iaai?th a i?aai?ci?, eiai ?aaoeyoe?y, ui iaoiiaeththoue
c?ooaiiy aioo??oiueiee?oeiiiai ai?noo ?ii?a iaai?th ?, a?aeiia?aeii,
?oiueiai ooieoe?iiaeueiiai cia/aiiy, aieea ia iueiai aioea?ia?oaiceaii?
oa?iaeioa?ai?? aea/aiee iaiiaii, a ?acoeueoaoe noia?a/eea?, oi/a naia
aieea ia ciai?oi?e aaeain iaai?th iiaea i?eaanoe aei ei?aeoe?? ii?ooaiue
eiai iaoaaie?cio, i?aeo?eiaiiy aiiainoaco ? i?aeaeuaiiy aoaeoeaiino?
e?eoaaiiy AA.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeany a?aeiia?aeii aei iniiaieo ieai?a IAe? ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea, aoaeo/e o?aaiaioii oaie
“?ic?iaeoe ? ai?iaaaeeoe a i?aeoeeo ioi?iie caei?ia’y oaoiieia??
i?io?eaeoeee ? e?eoaaiiy a?oa??aeueii? a?ia?oaic?? ca aeiiiiiaith
iia?oi?o aioea?ia?oaiceaieo cania?a ? iaiaaeeeaiaioicieo iaoiae?a
e?eoaaiiy (? Aea?ae?a?no?aoe?? 0198O004009)” ? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, aoaeo/e o?aaiaioii oaie “?ic?iaea
iaoiae?a ?aiiuei? ae?aaiinoeee ? oa?iaeieia?/ii? ei?aeoe?? ii?ooaiue
iaoai?ci?a ?aaoeyoe?? ?ci?ii??, ?ciaieai?? ? ?cioii?? i?e a?oa??aeuei?e
a?ia?oaic?? ? o?ii?/i?e na?oeaa?e iaaeinoaoiino?” (? Aea?ae?a?no?aoe??
0197V018403).

Iaoa ? caaea/? aeine?aeaeaiiy. Iniiaiith iaoith aeine?aeaeaiiy aoei
aea/aiiy noaio aiiainoaco iaai?th i?e AA aeey ?icoi?iiy iaoai?ci?a
?icaeoeo AA, ?ic?iaee iioeiaeueieo iaoiae?a ei?aeoe?? ii?ooaiue
iaoaaie?cio iaai?th, iaa?oiooaaiiy e?eoa???a aeai?o oa i?aeaeuaiiy
aoaeoeaiino? aioea?ia?oaiceaii? oa?ai?? (AAO) aeey iioei?caoe??
i?iaaaeaiiy i?io?eaeoeee AA. A?aeiia?aeii aei oeueiai aoee
noi?ioeueiaai? ianooii? caaea/?:

1. Ioe?ieoe noai iaoaaie?cio iaai?th i?e ??cieo noaae?yo AA ? aecia/eoe
iaoie?iaoe/io ?ieue ii?ooaiue iaoaaie?cio iaai?th aeey ?icoi?iiy
iaoai?ci?a noaiiaeaiiy ? noaa?e?caoe?? AA.

2. Aeine?aeeoe noai ai?iiiaeueii? ?aaoeyoe?? iaoaaie?cio iaai?th ca
aeiiiiiaith niaoeeo?/ieo ai?iii?a — ia?aoai?iiia (IOA), eaeueoeeoii?ia
(EO), ai?iiiaeueii-aeoeaiiai iaoaaie?oo (a?oai?ia Ae3) a oiiaao
iaaaioaaeoaaeueieo oano?a ?c nieyie iaai?th, ae?o?aoeeaie ? c
?aaoethth/eie ai?iiiaie.

3. Aea/eoe noai an?o naeoi??a iaoaaie?cio iaai?th o oai?eo ia AA oeyoii
aecia/aiiy ciai?oiueiee?oeiiiai, aioo??oiueiee?oeiiiai ai?noo, eeoeiai?
aani?aoe?? oa iaai?eo?aoe/ii? ooieoe?? ie?ie a oiiaao iaai??aeo
iaaaioaaeaiue.

4. Aeine?aeeoe o oai?eo ia AA ?ioaineai?noue o?ainii?oo iaai?th i?ae
ie?eiaei oa e?noeiaei naeoi?aie.

5. ?ic?iaeoe aaeaeaaoi? iaoiaee ioe?iee noaio iaoaaie?cio iaai?th aeey
ee?i?/ii? i?aeoeee (oaeaee?noue ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i??
(OAIMg++), eeoeiai? aani?aoe?? iaai?th).

6. Iaa?oiooaaoe e?eoa??? aeai?o aioea?ia?oaiceaieo i?aia?ao?a a
caeaaeiino? a?ae noaio iaoaaie?cio iaai?th o oai?eo ia AA.

7. Cai?iiiioaaoe iioeiaeuei? iaoiaee ei?aeoe?? ii?ooaiue iaoaaie?cio
iaai?th o oai?eo ia AA.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa ia i?aenoaa?
i?iaaaeaiiai eiiieaeniiai iaii?aiiiai aeine?aeaeaiiy noaio iaoaaie?cio
iaai?th i?e AA: aecia/aia iaoie?iaoe/ia ?ieue eiai ii?ooaiue aeey
oi?ioaaiiy ? ?icaeoeo AA; aecia/aiee noai ai?iiiaeueii? ?aaoeyoe??
iaoaaie?cio iaai?th o oai?eo ia AA ca aeiiiiiaith IOA, EO ?
ai?iiiaeueiiaeoeaiiai iaoaaie?oo a?oai?ia Ae3 a oiiaao
iaaaioaaeoaaeueieo oano?a ?c nieyie iaai?th ? ?aaoethth/eie ai?iiiaie;
aea/aii noai ? ?ieue ii?ooaiue eeoeiai? aani?aoe?? iaai?th o oai?eo ia
AA ca aeiiiiiaith ?ic?iaeaiiai iaie ia?i?aeueiiai ? aioo??oiueiaaiiiai
iaaaioaaeoaaeueiiai oanoo; ioe?iaii noai iaai?eo?aoe/ii? ooieoe?? ie?ie
? ?ieue ?? ?iceaae?a o ?icaeoeo AA; c’yniaaii o oai?eo ia AA
ni?yiiaai?noue ie?eiaiai o?ainii?oo ia oo?eiaiiy eaeueoe?th oeyoii
ia?aaaaeiiai aeaaaeaiiy iaai?th; ?ic?iaeai? aaeaeaaoi? iaoiaee ioe?iee
noaio iaoaaie?cio iaai?th aeey ee?i?/ii? i?aeoeee (oaeaee?noue
ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i??, eeoeiaa aani?aoe?y iaai?th); a
caeaaeiino? a?ae noaio iaoaaie?cio iaai?th o oai?eo ia AA iaa?oioiaai?
e?eoa??? aeai?o AAO; aecia/ai? iaoiaee ei?aeoe?? ii?ooaiue iaoaaie?cio
iaai?th o oai?eo ia AA.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeaii iaoiae
aecia/aiiy eeoeiai? aani?aoe?? iaai?th a ee?i?oe?. Aecia/aii oa?aeoa?
ni?aa?aeiioaiiy ie?eiaiai o?ainii?oo iaai?th ? eaeueoe?th ? aecia/aia
?ioaineai?noue o?ainii?oo iaai?th i?ae iicaee?oeiiei ? e?noeiaei
naeoi?ii o oai?eo ia AA. ?ic?iaeai? aaeaeaaoi? iaoiaee ioe?iee noaio
iaoaaie?cio iaai?th a ee?i?/i?e i?aeoeoe? ? cai?iiiiiaai? iioeiaeuei?
iaoiaee ei?aeoe?? ii?ooaiue iaoaaie?cio iaai?th o oai?eo ia AA.
Aecia/aia caeaaei?noue oa?ai?? ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai
oa?iaioo (AIO), aioaaii?noaie eaeueoe?th, aaoa-aae?aiiaeieaoi?aie oa
ae?o?aoeeaie a?ae noaio iaoaaie?cio iaai?th o oai?eo ia AA oa
iaa?oioiaai? e?eoa??? aeai?o AAO.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. Iaoa??aee
aeena?oaoe?eii? ?iaioe a?aeia?aaeai? a iaoiaee/ieo ?aeiiaiaeaoe?yo
“No/ani? i?eioeeie e?eoaaiiy a?oa??aeueii? a?ia?oaic?? (Ee?a, 1997), o
Iaoaio? ? 2079129 ia aeiao?ae: “Niin?a ae?aaiinoeee eaoaioii? oi?ie
o?ii?/iiai i??eiiao?eoo o oai?eo ?c a?ia?oaiceaiei neiae?iiii aac
noiooi?o o?ieia?/ieo caoai?thaaiue” (iaoaioiaeaniee Oe?IAe? ea?ae?ieia??
?i. aeaae. I.Ae.No?aaeanea) o ni?aaaoi?noa?, aeaeaiee Eii?oaoii
?in?enueei? Oaaea?aoe?? ii iaoaioao ? oiaa?ieo ciaeao (?iniaoaio)
10.05.97 ? i’youeio ?aoe?iiae?caoi?nueeeo i?iiiceoe?yo o ni?aaaoi?noa?,
caoaa?aeaeaieo Aeiiaoeueeei iaaee/iei oi?aa?neoaoii: ?aoei?iiiceoe?y
?5742 “Niin?a i?aeaeuaiiy aioea?ia?oaiceaii? aoaeoeaiino? ?ia?a?oi??a
aia?ioaicei-ia?aoai?thth/iai oa?iaioo a in?a ?c aenieei ??aiai
aeoeaiino? ?ai?io ieacie” (1996); ?aoei?iiiceoe?y ?5743 “Niin?a
i?aeaeuaiiy aioea?ia?oaiceaii? aoaeoeaiino? ?ia?a?oi??a
aia?ioaicei-ia?aoai?thth/iai oa?iaioo a in?a ?c iecueeei ? ii?iaeueiei
??aiai aeoeaiino? ?ai?io ieacie” (1996); ?aoei?iiiceoe?y ?5744 “Niin?a
i?aeaeuaiiy aioea?ia?oaiceaii? aoaeoeaiino? aioaaii?no?a eaeueoe?th a
in?a ?c aenieei ??aiai aeoeaiino? ?ai?io ieacie” (1996); ?aoei?iiiceoe?y
?5745 “Niin?a i?aeaeuaiiy aioea?ia?oaiceaii? aoaeoeaiino? aioaaii?no?a
eaeueoe?th a in?a ?c iecueeei ? ii?iaeueiei ??aiai aeoeaiino? ?ai?io
ieacie” (1996); ?aoei?iiiceoe?y ?5754 “Niin?a iioei?caoe?? ae??oe ?10
aeey oai?eo a?ia?oii?/iith oai?iaith oeyoii ei?aeoe?? niiaeeaaiiy
iaai?th a ae??o?” (1996).

?acoeueoaoe aeine?aeaeaiue ? iaoiaee/i? ?aeiiaiaeaoe?? ai?iaaaeaeai? ?
aeei?enoiaothoueny c iiceoeaiei nioe?aeueii-aeiiii?/iei ?
e?eoaaeueii-i?io?eaeoe/iei aoaeoii o ea?ae?ieia?/ieo ? oa?aiaaoe/ieo
a?aeae?eaiiyo iaeanieo ? i?nueeeo e?ea?aiue Caii??aeaey, Oa?eiaa,
Aei?i?iiao?ianueea, Aeiiaoeueea, Eoaainueea, A?iieoe?, Iaeane, Eueaiaa,
Oa?iiiiey, ?aaii-O?aie?anueea. ?acoeueoaoe aeena?oaoe?eii? ?iaioe
ai?iaaaeaeai? a iaa/aeueiee i?ioean eaoaae? oa?ai?? ? ea?ae?ieia??
Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea,
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. I.I.Aiaiiieueoea (Ee?a),
Aei?i?iiao?ianueei? iaaee/ii? aeaaeai??, Aeiiaoeueeiai iaaee/iiai
oi?aa?neoaoo ?i.I.Ai?ueeiai, Eoaainueeiai iaaee/iiai oi?aa?neoaoo,
Caii??cueeiai ?inoeoooo oaeineiiaeaiiy e?ea??a, Euea?anueeiai iaaee/iiai
oi?aa?neoaoo, ?aaii-O?aie?anueei? iaaee/ii? aeaaeai??, Oa?iii?euenueeiai
iaaee/iiai oi?aa?neoaoo ?i.?.ss.Ai?aa/aanueeiai, ui i?aeoaa?aeaeo?oueny
aeoaie ai?iaaaeaeaiiy.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? naiino?eiei
iaoeiaei aeine?aeaeaiiyi. Aaoi?o iaeaaeeoue ?aeay nenoaiiiai aea/aiiy
noaio iaoaaie?cio iaai?th i?e AA (o?aeoe?eiee neeaae iaai?th a e?ia?,
iaai?eo?aoe/ia ooieoe?y ie?ie, eeoeiaa aani?aoe?y iaai?th, ae??oe/ia
niiaeeaaiiy, eiioeaio?aoe?y iaai?th a a?eo?ioeeoao, o?ainii?o iaai?th
i?ae iicaee?oeiiith ??aeeiith ? e?noeaie, ai?iiiaeueia ?aaoeyoe?y
iaoaaie?cio iaai?th a oiiaao iaaaioaaeoaaeuei?o oano?a c nieyie iaai?th,
c ?aaoethth/eie ai?iiiaie (IOA, a?oai?i Ae3), c ae?o?aoeeaie. Aaoi?ii
i?iaaaeaiee aiae?c ?acoeueoao?a aeine?aeaeaiiy o oai?eo ia AA, a oaeiae
aeeiiaiee aiae?c ni?aa?aeiioaiiy ie?eiaiai o?ainii?oo eaeueoe?th ?
iaai?th i?e AA. Caeiaoaa/ naiino?eii ?ic?iaeea i?ia?aio aeine?aeaeaiiy,
aeeiiaea a?aea?? oaiaoe/ieo oai?eo, ?ic?iaeea aaeaeaaoi? iaoiaee ioe?iee
noaio iaoaaie?cio iaai?th, aeinooii? a ee?i?/i?e i?aeoeoe? (OAIMg++,
eeoeiaa aani?aoe?y iaai?th) oa aecia/eea e?eoa??? aeai?o AAO a
caeaaeiino? a?ae noaio iaoaaie?cio iaai?th. Aiae?c oa ocaaaeueiaiiy
?acoeueoao?a, noaoenoe/ia ii?aoethaaiiy iaoa??aeo, i?aeaioiaea
iiiia?ao??, iaeyaeiaeo oa i?ea?iaeueieo noaoae, ioi?ieaiiy
aeena?oaoe?eii? ?iaioe oa aaoi?aoa?aoo cae?eniai? caeiaoaa/ai
naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aena?oeai? ? iaaiai?thaaeenue ia 1-io Iaoe?iiaeueiiio c’?cae?
oa?iaeieia?a Oe?a?ie (Iieoaaa, 1995), 2-e I?aeia?iaei?e eiioa?aioe??
caei?iaiai na?oey (Aa?naeiia, ?niai?y, 1995), 7-e ?a?iiaenuee?e
eiioa?aioe?? ii oa?/oaaiith (A?aeaiue, Aano??y, 1995), 23-io eiia?an?
I?aeia?iaeiiai oiaa?enoaa ii aioo??oi?e iaaeeoeei? (Iai?ea, O?e?i?ie,
1996), c’?cae? ea?ae?ieia?a Iieaeiae (Eeoei?a, Iieaeiaa, 1996), 1-io
Eiia?an? anioe?aoe?? ea?ae?ieia?a e?a?i NIAe (Iineaa, 1997), 3-io
eiia?an? anioe?aoe?? ea?ae?ieia?a e?a?i Na?aaeiuei? Ac?? (Oaoeaio,
Ocaaeenoai, 1997), 5-io eiia?an? ea?ae?ieia?a Oe?a?ie (Ee?a, 1997), 7-io
I?aeia?iaeiiio neiiic?oi? ii na?oeaai-noaeeii?e oa?iaeioa?ai??
(???onae?i, ?c?a?eue, 1997), 16-io I?ai?/iiio eiia?an? ea?ae?ieia?a
(Oaiia?a, O?ieyiae?y, 1997), 8-e ?a?iiaenuee?e eiioa?aioe?? ii
a?ia?oaic?? (I?eai, ?oae?y, 1997), 4-e i?aeia?iaei?e eiioa?aioe?? ii
i?aaaioeai?e ea?ae?ieia?? (Iii?aaeue, Eaiaaea, 1997), 1-io
I?aeia?iaeiiio eiia?an? Iieuenueeiai ea?ae?ieia?/iiai oiaa?enoaa
(Aa?oaaa, Iieueua, 1997), 2-e eiioa?aioe?? e?a?i
I?aaeaiii-Oeoiieaainueeiai ?aa?iio ii a?ia?oaic?? (Iai?ea, O?e?i?ie,
1997), 5-e I?aeia?iaei?e eiioa?aioe?? ii ea?ae?ieia?? (A?aoe, Aano??y,
1997), 1-io eiia?an? ii aioo??oi?e iaaeeoeei? (Iaano??oo, I?aea?eaiaee,
1997), 13-e Anana?oi?e eiioa?aioe?? Oaaea?aoe?? ? oiaa?enoaa
ea?ae?ieia?a (??i aea AEaiae?i, A?acee?y, 1998), 13-io Iaoeiaiio
neiiic?oi? Aia?eeainueeiai oiaa?enoaa ii a?ia?oaic?? (Iueth Ei?e, NOA,
1998), 17-io Iaoeiaiio neiiic?oi? i?aeia?iaeiiai oiaa?enoaa ii
a?ia?oaic?? (Ainoa?aeai, I?aea?eaiaee, 1998), 14-io c’?cae? oa?aiaao?a
Oe?a?ie (Ee?a, 1998), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“A?oa??aeueia a?ia?oaic?y oa a?e” (Ee?a, 1998), 1-io
?ioa?iaoe?iiaeueiiio eiia?an? ii na?oeaaeo oai?iaao (Aaoeiaoii, NOA,
1999), 9-e ?a?iiaenuee?e eiioa?aioe?? ii a?ia?oaic?? (I?eai, ?oae?y,
1999).

Aeena?oaoe?eio ?iaioo ?icaeyiooi ? ?aeiiaiaeiaaii aei caoenoo ia
iaoeia?e eiioa?aioe?? ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea
(1999) oa ia iaoeia?e eiioa?aioe?? ni?eueii c can?aeaiiyi Ai?iaaoe?eii?
?aaee ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie
(1999 ?.).

Ioae?eaoe??. Iaoa??aee aeena?oaoe?eii? ?iaioe aena?oeai? a iiiia?ao??
“Anaioe?aeueia a?ia?oaic?y ? aiiainoac eaeueoe?th” (E., *aoaa?oa oaeey,
1998.-195 n.- ae. 5, 6, 7, 8) oa 70 iioae?eiaaieo ?iaioao, o oiio /ene?
naiino?eieo — 16. Na?aae ieo noaoo? a iaoeiaeo aeo?iaeao — 14 (c ieo 5
naiino?eieo), iaoaio -1 (o ni?aaaoi?noa?), aeiiia?ae? ia c’?caeao — 23,
8 noaoae o ca??ieeao iaoeiaeo i?aoeue, 21 oac aeiiia?aeae ia iaoeiaeo ?
iaoeiai-i?aeoe/ieo eiioa?aioe?yo. Ca ei?aeiiii iioae?eiaaii 38 iaoeiaeo
i?aoeue.

Ia’?i ? no?oeoo?a ?iaioe. ?iaioa iaienaia ia 344 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, 6
?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e. ?ethno?iaaia 49 oaaeeoeyie ? 28 iaethieaie. Nienie
aeei?enoaii? e?oa?aoo?e aeeth/a? 591 aeaea?ae, na?aae yeeo 90
a?o/eciyieo ? 501 ?iicaiieo aaoi??a.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Ianoaaeaii 348 oai?eo, ?c eio?eo 267
oai?eo ia AA o a?oe? a?ae 30 aei 55 ?ie?a (159 /ieia?e?a ? 108 ae?iie).
O 32 oai?eo aeyaeaia AA I noaae??, o 207 — II noaae?? oa o 28 — III
noaae?? (ii eeaneo?eaoe?? AIIC). Na?aaei?e a?e neeaa 46.8±1.3 ?ieo.
O?eaae?noue ae?aaiinoiaaiiai caoai?thaaiiy eieeaaeany a?ae 2-o aei 18
?ie?a. ??aaiue nenoie?/iiai AO eieeaaany a?ae 140 aei 226 ii ?o. no.,
neeaaeath/e a na?aaeiueiio 182,8±5,3 ii ?o. no. ??aaiue ae?anoie?/iiai
AO eieeaaany a?ae 96 aei 126 ii ?o. no., neeaaeath/e a na?aaeiueiio
108,2±3,2 ii ?o.no. O /anoeie oai?eo ia AA i?iaaaeaia aeiaiaa
iii?oi?oaaiiy AO ca ?aeiiaiaeaoe??th oao?aoe?a ?in?enueeiai
iaoeiai-ae?iaie/iai eiiieaeno IIC ?O (A.A. A?aa?aeca, I.TH. Aoueeia,
1997). Ianoaaeaiiy, e??i caaaeueiiee?i?/iiai, o?ceeaeueiiai,
eaai?aoi?iiai oa ?ino?oiaioaeueiiai, aeeth/aei ?yae oano?a aeey
aeeeth/aiiy neiioiiaoe/ieo a?ia?oaic?e. Aeey aeeoa?aioe?aeueii?
ae?aaiinoeee i?ae neiioiiaoe/iith oa anaioe?aeueiith a?ia?oaic??th ie
ei?enooaaeenue niaoe?aeueiith i?ia?aiith ianoaaeaiiy oai?eo ia AA,
cai?iiiiiaaio a ?inoeooo? ea?ae?ieia?? ?i. I.E. Iynieeiaa AIEOe.
Ianoaaeaii 70 caei?iaeo in?a (eiio?ieueia a?oia c ii?iaeueiei ??aiai AO)
aac iciae caoai?thaaiue na?oeaai-noaeeiii? nenoaie, ie?ie,
oeoieiai-eeoeiaiai o?aeoo ? e?noeiai? nenoaie i?ae /an ianoaaeaiiy aai a
ieioeiio. A?e ianoaaeaieo eiio?ieueii? a?oie neeaaeaa 25-56 ?ie?a,
na?aaei?e a?e 44.0±1.4 ?iee. Aaeeea /anoeia caei?iaeo ? oai?eo ia AA
in?a aoea ianoaaeaia iaiaeii?aciai a i?ioean? oa?iaeioa?ai?? AA ?
iaaaioaaeoaaeueieo oano?a. E??i oiai, ianoaaeaii 11 oai?eo ?c
neiioiiaoe/iith ie?eiaith a?ia?oaic??th o a?oe? a?ae 28 aei 52 ?ie?a,
na?aaei?e a?e 41.1±1.5 ?iee. ?iciiae?e ianoaaeaieo ca iicieia?/ieie
oi?iaie, a?eii, noaooth i?aaenoaaeaiee o oaae. 1.

E?eoaaiiy oai?eo i?iaiaeeee ?ia?a?oi?aie AIO, aioaaii?noaie eaeueoe?th,
aaoa-aae?aiiaeieaoi?aie, ae?o?aoeeaie. Aoaeoeai?noue e?eoaaiiy aaaaeaee
aenieith, yeui aiia aeinyaaeany iiiioa?ai??th i?aia?aoii o na?aaei?e
aeic?, na?aaeiuei? — o aenie?e aeic?, ieceith — o aenie?e aeic? oa o
eiia?iaoe?? c ?ioeie aioea?ia?oaiceaieie i?aia?aoaie.

An? ianoaaeaiiy i?iaiaeeee i?ney 5-7 aeaiii? ia?a?ae a i?eeii?
aioea?ia?oaiceaieo i?aia?ao?a. Oai?? a ia??iae ianoaaeaiiy iaea?aeoaaee
noaiaea?oio ae??oo N 10 ii Iaacia?o, ca yeith a i?aai?ci iaaeoiaeeoue ca
aeiao a?ey 14 iiieue iaai?th, 16,5 iiieue eaeueoe?th, 90 iiieue iao??th,
70 iiieue eae?th, 80 a a?eea, 70 a aee?o, 400 a aoaeaaiae?a.
Iaaaioaaeoaaeuei? oanoe i?iaiaeeee iaoua ?aieii /a?ac 16 aiaeei i?ney
inoaiiueiai i?eeiio ?ae?. O?eaae?noue oa?iaeioa?ai?? neeaaeaea a?ae 3
aei 6 i?nyoe?a.

Ianoaaeaiiy oai?eo aeeth/aei aea/aiiy noaio iaoaaie?cio iaai?th c
oa?aeoa?enoeeith eiaeiiai eiai naeoi?a, ye? cae?eniththoue ye eiai
ciai?oi?e aaeain (ae??oe/ia niiaeeaaiiy, eeoeiao aani?aoe?th, ie?eiao
aene?aoe?th), oae ? caaacia/othoue aioo??oith ??aiiaaao (iaai??i?th,
aioo??oiueiee?oeiiee ai?no iaai?th a a?eo?ioeeoao, o?ainii?o i?ae on?ia
naeoi?aie, aeeth/ath/e iai?i i?ae iicaee?oeiiith ??aeeiith, e?noeaie ?
ie?eaie, aioo??oiueiie?eiaee o?ainii?o), a oaeiae ai?iiiaeueio
?aaoeyoe?th iaoaaie?cio iaai?th niaoeeo?/ieie ai?iiiaie — IOA, EO,
ai?iiiaeueii-aeoeaiei iaoaaie?oii a?oai?io Ae3 —
1,25-ae?a?ae?ien?oieaeaeueoeeoa?ieii (1,25(OH)2Ae3).

Oaaeeoey 1

?iciiae?e ianoaaeaieo oai?eo a?oa??aeueiith a?ia?oaic??th

ca iicieia?/ieie oi?iaie, a?eii ? noaooth

Iicieia?/ia oi?iaA?e (?iee) ? noaoueAnueiaina?aaei?e

a?eaei 30 30-3940-4950-60/ae/ae/ae/aeAA I noaae??73144-4—3246.81.3AA II
noaae??4228169014712820746.81.3AA III noaae??—11139-42846.81.3Oai??
neiioiiaoe/iith ie?eiaith
a?ia?oaic??th—2333—1142.11.5Caei?ia?72131417152-7044.01.4Anueiai187584
811378141234844.31.4

Aeey oa?aeoa?enoeee iaai??i?? aecia/aee caaaeueio eiioeaio?aoe?th
iaai?th a ne?iaaooe? e?ia? iaoiaeii aoiiii-aani?aoe?eii?
niaeo?ioioiiao??? ia niaeo?ioioiiao?? “Naoo?i-3” ? eiioeaio?aoe?th
?ii?ciaaii? o?aeoe?? iaai?th iaoiaeii i?yii? iioaioe?iiao??? c
aeei?enoaiiyi ?iiinaeaeoeaiiai eaeueoe?e-iaai??aiai aeaeo?iaea,
aeaioiaeaiiai a Naieo-Iaoa?ao?cueeiio oi?aa?neoao?.

Ie?eiaee o?ainii?o iaai?th ioe?ithaaee oeyoii aea/aiiy aene?aoe??
iaai?th, eiai ee??aino, o?eueo?aoe?eiiai ca?yaeo (OC) ? aene?aoiaaii?
o?aeoe?? (AO), aecia/aee ae?o?ac ? oaeaee?noue eeoai/eiai? o?eueo?aoe??
(OEO). Iaai?eo?aoe/io ooieoe?th ie?ie ioe?ithaaee a cae/aeieo oiiaao
(aeiaiaa aene?aoe?y iaai?th; ee??ain-aeine?aeaeaiiy i?e iii??iiio
aioeae?o?ac?) ? a oiiaao iaaaioaaeaiue (aioo??oiueiaaiiee, ia?i?aeueiee
? iiaea?eiee iaai?eoiea?aioiee oano (IOO); aeciaaiia aaaaeaiiy IOA,
ia?i?aeueiee i?eeii ieneaeaa?oa (aiaeiaa a?oai?io Ae, ui ia? oi?ioeo
1-a-IIAe3 ? iaoaaie?co?oueny a ia/?ioe? a 1,25(OH)2Ae3). Ioe?ithaaee
oaeiae eaeueoe?eo?aoe/io ? iao??eo?aoe/io ooieoe?th ie?ie.
Eiioeaio?aoe?th iaai?th ? eaeueoe?th a na/? aecia/aee ca aeiiiiiaith
aoiiii-aani?aoe?eii? niaeo?ioioiiao???. Eiioeaio?aoe?th iao??th a e?ia?
? na/? aecia/aee ia iieoi’yiiio oioiiao?? “Oeaenn-3”.

Aioo??oiueiee?oeiio eiioeaio?aoe?th iaai?th aei??thaaee a a?eo?ioeeoao
ca aeiiiiiaith aoiiii-aani?aoe?eii? niaeo?ioioiiao??? i?ney a?aeae?eaiiy
? iaoai?/ii? ?oeiaoe?? a?eo?ioeeoa?ii? iane.

Eeoeiao aani?aoe?th iaai?th oa?aeoa?ecoaaee ca aeiiiiiaith
ia?i?aeueiiai ? aioo??oiueiaaiiiai iaaaioaaeaiiy nieyie iaai?th,
ioe?ithth/e aeeiai?eo iaai??i?? /a?ac 120 oa.i?ney ia?i?aeueiiai ?
aioo??oiueiaaiiiai iaaaioaaeaiiy n?eeth iaai?th a aeic? 0,1 iiieue ia 1
ea iane o?ea.

C iaoith ioe?iee aeiaiaiai niiaeeaaiiy iaai?th aeei?enoiaoaaee: 1)
noaiaea?oio aieaoo i?i niiaeeaaiiy i?iaeoeo?a oa?/oaaiiy ca 24 aiaeeie
ca aeiiiiiaith ioeyae?a aioiaeo i?iaeoeo?a ? aethae ?c ianooiiei
?ic?aooieii ai?noo a ae??o? iaai?th; 2) aecia/aiiy ie?eiai? aene?aoe??
iaai?th, eaeueoe?th ? iao??th a aeiaia?e na/?.

Noai o?ainii?oo iaai?th i?ae iicaee?oeiiith ??aeeiith ? e?noeaie
oa?aeoa?ecoaaee, aecia/ath/e iaaeoiaeaeaiiy iaai?th c e?noee a ieacio
e?ia? ca iaoiaeii ?.I.??iaeiai? (1987).

Eiioeaio?aoe?th ai?iii?a o ne?iaaooe? e?ia? aei??thaaee ?aae?i?ioiiei
iaoiaeii ca aeiiiiiaith iaai??a “Malinkrodt diagnostica” (IOA), “Ria-mat
calcitonin-II” (EO), “Bullmann” (1,25(OH)2Ae3).

Aeey aaeaeaaoii? oa?aeoa?enoeee noaio iaoaaie?cio iaai?th
aeei?enoiaoaaee IOO, ui aeicaiey? iaea?aeaoe eiai ocaaaeueiaio
e?euee?nio oa?aeoa?enoeeo ia ??ai? i?aai?cio, aeniei aeioeoeueiee ?
/ooeeaee aei ii??aiyii iaaaeeeeo c?ooaiue. Aioo??oiueiaaiiee IOO
i?iaiaeeee oeyoii aioo??oiueiaaiiiai aaaaeaiiy 0,1 iiieue iaai?th
noeueoaoo ia 1 ea iane o?ea. E?ia ?c aaie a?aee aei aaaaeaiiy noeueoaoo
iaai?th, /a?ac 20 ? 150 oaeeei i?ney eiai aaaaeaiiy. I?e i?iaaaeaii?
ia?i?aeueiiai IOO i?ney acyooy e?ia? c e?eoueiai? aaie ethaeeia, yea
ianoaaeo?oueny, i?eeiaea ia?i?aeueii ania?eai ?c ?ic?aooieo 0,1 iiieue
iaai?th ia ea iane o?ea, caieaath/e eiai 100 ie aeenoeeueiaaii? aiaee.
??aaiue iaai??i?? aecia/aee /a?ac 120 ? 240 oaeeei.

E??i iieaciee?a aacaeueiiai noaio iaoaaie?cio iaai?th, aea/aee aieea ia
ieo aino?eo ? o?ii?/ieo iaaaioaaeaiue (aioo??oiueiaaiiiai ?
ia?i?aeueiiai IOO, o oiio /ene? iiaea?eieo, ?c i?ieiiaiaaiei
iaaaioaaeaiiyi nieyie iaai?th, ai?iiiaie — IOA (aioo??i’ycaaa aaaaeaiiy
0,5 IAe ia?aoe?ai?aeeio ia 1 ea iane o?ea) ? 1,25(OH)2Ae3 (ia?i?aeueiee
o?eaeaiiee i?eeii ieneaeaa?oo iaeei ?ac ia aeiao a aeic? 1 iea),
aioea?ia?oaiceaieie oa?iaeieia?/ieie i?aia?aoaie.

Noai oeaio?aeueii? aaiiaeeiai?ee ? ia?eoa?e/iiai e?iaioieo ioe?ithaaee
ca aeiiiiiaith AoiEA ? ieethc?eii? ieaoeciia?ao?? a ia??iae niieith,
i?ney i?eeiio aioea?ia?oaiceaieo oa?iaeii?aia?ao?a, nieae iaai?th ? a
oiiaao o?ce/iiai iaaaioaaeaiiy ia aaeia?aiiao??.

Ee?i?/ia aeine?aeaeaiiy c ei?aeoe??th ii?ooaiue iaoaaie?cio iaai?th
i?iaaaeaii o oai?eo “i’yeith” ? “iii??iith?” a?ia?oaic??th
(ae?anoie?/iee AO a iaaeao 95-114 ii ?o. no.) c ioe?ieith ae??oe/iiai
aeiaiaiai niiaeeaaiiy iaai?th aaciina?aaeiuei ia?aae ? i?ney 3-
i?ny/iiai uiaeaiiiai i?eeiio ania?eaia a aeiaia?e aeic? 0,10 iiieue/ea
iane o?ea.

?acoeueoaoe aeine?aeaeaiiy.

Aiiainoac iaai?th i?e anaioe?aeuei?e a?ia?oaic?? (iaoio?c?ieia?y
iaoaaie?cio iaai?th). O oai?eo ia AA i? eiioeaio?aoe?y ?ii?ciaaiiai
iaai?th, i? eiai caaaeueia eiioeaio?aoe?y ?noioii ia a?ae??ciythoueny
a?ae iieaciee?a o caei?iaeo ianoaaeaieo eiio?ieueii? a?oie (oaae. 2). O
oai?eo ia AA ?c ??ciei ??aiai AO ae?aaeai? ?icoiaeaeaiiy a ??ai?
?ii?ciaaii? eiioeaio?aoe?? iaai?th a?aenooi?. Iaeiae o oai?eo ?c aenieei
noaa?eueiei ??aiai ae?anoie?/iiai AO, ui ia?aaeuo? 115 ii ?o. no.,
eiioeaio?aoe?y ?ii?ciaaiiai iaai?th a 86% aeiaaee?a ia ia?aaeuo? ??aaiue
ieaeiuei? eaa?oee? (0,50 iiieue/e) ? a aeiaeiiai oai?iai c aenieith AA
eiioeaio?aoe?y ?ii?ciaaiiai iaai?th ia aeinyaa? ??aiy aa?oiuei?
eaa?oee?.

Iaie ia aeyaeaii aeinoia??ii? caeaaeiino? ??aiy iaai??i?? a?ae a?eo. O
oai?eo ?c III no. caoai?thaaiiy eiioeaio?aoe?y ?ii?ciaaiiai iaai?th ia?
oaiaeaioe?th aei cieaeaiiy. Oaeei /eiii, eiioeaio?aoe?y iaai?th a
ne?iaaooe? e?ia? oai?eo ia AA i?aeo?eio?oueny i?aeoe/ii a ii?iaeueieo
iaaeao. Oea oe?eeii c?icoi?ei, yeui a?aooaaoe, ui cia/i? a?aeoeeaiiy
eiioeaio?aoe?? iicaee?oeiiiai iaai?th na?ae/aoue i?i aeeaie?
ooeiaeaeaiiy a nenoai? ?aaoeyoe?? aiiainoaco iaai?th, ui, i/aaeaeii, ia
ia? i?noey i?e AA.

O caei?iaeo ianoaaeaieo eiioeaio?aoe?y iaai?th a a?eo?ioeeoao neeaea
1,37-1,69, o na?aaeiueiio 1,52±0,02 iiieue/e, o oai?eo ia AA — 0,96-1,81
iiieue/e, o na?aaeiueiio 1,38±0,02 iiieue/e, oiaoi noaoenoe/ii
aeinoia??ii iaioa, i?ae o caei?iaeo ianoaaeaieo (p<0,001). Aioo??oiueia?eo?ioeeoa?ia eiioeaio?aoe?y eaeueoe?th o caei?iaeo ianoaaeaieo neeaea 0,96-1,32 iiieue/e, o na?aaeiueiio 1,14±0,02 iiieue/e, o oai?eo ia AA aiia eieeaaeany a a?eueoiio ae?aiacii? - a?ae 0,96 aei 1,52 iiieue/e, ? a na?aaeiueiio - 1,31±0,04 iiieue/e - aoea noaoenoe/ii aeinoia??ii aeua. Iao? aeai? i?i ei?aeyoe?eiee ca'ycie i?ae iica- ? aioo??oiueiee?oeiieie eiioeaio?aoe?yie iaai?th ? eaeueoe?th c iaeiiai aieo ? ??aiai AO c ?ioiai, na?ae/aoue i?i ?nioaaiiy iaea?eueo cia/eiiai ei?aeyoe?eiiai ca'yceo i?ae ??aiai AO ? eiioeaio?aoe??th iaai?th a a?eo?ioeeoao (eiao?oe??io ei?aeyoe?? -0,416) ? ni?aa?aeiioaiiyi Mg/Ca a a?eo?ioeeoao (eiao?oe??io ei?aeyoe?? -0,530), a?eueo iii?oii?, i?ae ca'ycie ?c eiioeaio?aoe??th eaeueoe?th a a?eo?ioeeoao (eiao?oe??io ei?aeyoe?? 0,397). Caeaaei?noue i?ae ??aiai AO ? ne?iaaoeiaeie eiioeaio?aoe?yie ?ii?a a?aenooiy. Iaea?eueo aaeaeaaoii noaeeoe i?i noai iaoaaie?cio iaai?th aeicaiey? aeeiai?ea iaai??i?? i?ney aaaaeaiiy a iicaee?oeiiee naeoi? aeiaeaoeiaiai iaai?th, ui noia?ii a?aeia?aaea? ni?iiiaei?noue i?aai?cio i?aeo?eioaaoe noae?noue oe??? iaeaaaeeea?oi? eiinoaioe. O i?aeo?eioe? ??aiy iaai??i?? i?ney aaaaeaiiy aeiaeaoeiaiai iaai?th a iicaee?oeiiee naeoi? aa?ooue o/anoue on? ?aaoeyoi?i? (IOA, EO, 1,25(OH)2Ae3) ? aeeiiaa/? (ie?eiaa aene?aoe?y, o?ainii?o i?ae iicaee?oeiiith ??aeeiith, e?noeith, ee?oeiaie, eeoeiaa aani?aoe?y) nenoaie iaoaaie?cio iaai?th. I?ney aioo??oiueiaaiiiai aaaaeaiiy iaai??aiai iaaaioaaeaiiy i?ioyaii ia?oeo 20 oaeeei a?aeaoaa?oueny ?? a?eueo-iaio ??aiii??iee ?iciiae?e o iicaee?oeiiiio naeoi??. ?icoiaeaeaiiy ?ici??o i?e?inoo caaaeueii? oa ?ii?ciaaii? eiioeaio?aoe?? iaai?th o caei?iaeo ianoaaeaieo iaoiiaeaii ??ciith oaeaee?noth e?iaioieo ? ??ciith ?ii?noth iicaee?oeiiiai naeoi?a iaai?th. Iaioee nooi?iue i?e?inoo eiioeaio?aoe?? ?ii?ciaaiiai iaai?th a ii??aiyii? c caaaeueiith iaoiiaeaiee ca'ycoaaiiyi aeiaeaoeiai aaaaeaieo ?ii?a iaai?th a?eeaie ? oaeaoieie eiiieaenaie ne?iaaoee e?ia? c caoeniith oe?eeth. O an?o caei?iaeo in?a ??aaiue iaai??i?? iiaa?oa?oueny aei aeo?aeiiai ia i?ci?oa 150-e oaeeeie i?ney aaaaeaiiy iaaaioaaeaiiy a e?ia. Cieaeaiiy eiioeaio?aoe?? caaaeueiiai oa ?ii?ciaaiiai iaai?th aei 150-? oaeeeie IOO i?aeoe/ii aei??aith? ?oiueiio i?e?inoo ia 20-e oaeeei?. O oai?eo ia AA i?e??no ye caaaeueii? eiioeaio?aoe?? iaai?th (0,42±0,01 iiieue/e), oae ? eiai ?ii?ciaaii? o?aeoe?? (0,22±0,01 iiieue/e) i?aeoe/ii ia a?ae??ciy?oueny a?ae i?e?inoo a caei?iaeo ianoaaeaieo, iaeiae iiaeaeueoa aeeiai?ea iaai??i?? a ieo ??cia. Cieaeaiiy eiioeaio?aoe?? iaai?th cae?enith?oueny iia?euei?oa ? ia iiaiith i??ith, oae ui a?aeiiaeaiiy aeo?aeiiai ??aiy iaai??i?? aei 150 oaeeeie ia aeinyaa?oueny. O oai?eo ia AA noaoenoe/ii oaeaee?noue ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i?? (OAIMg++) aeinoia??ii ieae/a (p<0,001), i?ae o caei?iaeo ianoaaeaieo (oaae. 2). Oaeei /eiii, yeui a caei?iaeo in?a ??aaiue iaai??i?? i?e IOO a?aeiiaeth?oueny i?aeoe/ii ia 100,0 %, oi o oai?eo ia AA - eeoa ia 56,5%. Iao? aeai? aeiaiaeyoue a?aenooi?noue ?icoiaeaeaiue o noai? iaoaaie?cio iaai?th i?e anaioe?aeuei?e ? neiioiiaoe/i?e AA. Aeeiai?ea iaai??i?? i?e ia?i?aeueiiio IOO i?aeoaa?aeaeo? oaiaeaioe??, aeyaeai? i?e aioo??oiueiaaiiiio IOO. Eiao?oe??io ei?aeyoe?? i?ae AO ? OAIMg++ aeoaea iecueeee - 0,113, ui aeicaiey? iai aaaaeaoe, ui ii?ooaiiy noaio iaoaaie?cio iaai?th, caaaeueiith oa?aeoa?enoeeith yeiai ? OAIMg++, ia ? i?inoith ooieoe??th ??aiy AO, a ?icaeaa?oueny aiane?aeie ii?ooaiiy ??cieo iaoai?ci?a eiai ?aaoeyoe??, ui i?ecaiaeeoue aei oi?ioaaiiy AA. Iaioa aoaeoeai?noue ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i?? o oai?eo ia AA iiaea aooe iaoiiaeaia aai ii?ooaiiyi i?iaeoeoe?? ai?iii?a, ui cae?eniththoue ?aaoeyoe?th iaoaaie?cio iaai?th, aai cieaeaiith /ooeea?noth i?aai?a-i?oaiae (ie?ie, e?noie, eeoiaieea, ee?oei) aei aieeao ai?iii?a. Iacaaaeath/e ia aacnoii?aii aecia/aeueio ?ieue ie?ie o iaoaaie?ci? iaai?th, eiai ie?eiaee o?ainii?o i?e AA i?aeoe/ii ia aea/aiee. Ae?o?ac ? aeiaiaa aene?aoe?y iaai?th a oiiaao eiai noaiaea?oiiai niiaeeaaiiy o oai?eo ia AA ia a?ae??ciyeeny a?ae iieaciee?a o caei?iaeo ianoaaeaieo. Oaeaee?noue eeoai/eiai? o?eueo?aoe??, aecia/aia ii ee??aino aiaeiaaiiiai e?aaoei?ia, o caei?iaeo ? oai?eo ia AA i?aeoe/ii iaeiaeiaa. ?ici?? OC o oai?eo ia AA, ye ? a caei?iaeo ianoaaeaieo, eieeaaany o aocueeiio ae?aiacii?. I?e?iaeiuei, ui i?e a?aenooiino? ?icoiaeaeaiue o eiioeaio?aoe?? ?ii?ciaaiiai iaai?th ieacie e?ia? ? OEO o ie?eao, OC iaai?th ia iiaea ?noioii ci?ieoeny. O oai?eo ia AA oaeiae i?aeoe/ii ia a?ae??ciy?oueny ? AO iaai?th a?ae iieacieea a caei?iaeo ianoaaeaieo. Oaeei /eiii, aiae?c iaoai?ci?a iaai?eo?aca aeicaiey? c?iaeoe aeniiaie i?i a?aenooi?noue a?aeoeeaiue yeiainue ?c oaeoi??a, ui aecia/athoue iaai?eo?ac - eeoai/eiaiai (OEO, OC) aai eaiaeueoeaaiai (AO), a oiiaao iaaeoiaeaeaiiy iaai?th a iii??ieo e?eueeinoyo. Ooieoe?iioaaiiy eeoai/eiaiai ? eaiaeueoeaaiai iaoai?ci?a o?ainii?oo iao??th o oai?eo ia AA aeecueei aei iieacieea o caei?iaeo in?a, ui iiynith? a?aenooi?noue a?aeoeeaiue o o?ainii?o? iaai?th ? eaeueoe?th, aaaaoi a /iio iao??ecaeaaeiiai. Oea iiynith? ? i?aeo?eiea ii?iaeueii? eiioeaio?aoe?? aeaiaaeaioieo ?ii?a iaai?th ? eaeueoe?th a ieaci? e?ia? oai?eo ia AA. O a?aeiia?aeue ia aioo??oiueiaaiia aaaaeaiiy iaai?th o oai?eo ia AA ie?eiaa aene?aoe?y iaai??aiai iaaaioaaeaiiy c?inoa? a iaioiio nooiai? ? iia?euei?oa, i?ae o caei?iaeo in?a (oaae.2). Aiane?aeie iaaaioaaeoaaeueii? iaai??i??, yea o oai?eo ia AA ia a?ae??ciyeany a?ae caei?iaeo, OC iaai?th c?inoaa iaeiaeiai a caei?iaeo ianoaaeaieo ? o oai?eo ia AA i?e iaci?ii?e OEO. Iaioee i?e??no AO iaai?th o oai?eo ia AA i?e ??aiiio c? caei?iaeie ethaeueie i?e?ino? eiai OC na?ae/eoue i?i iaioa o oai?eo ia AA i?eai?/aiiy eaiaeueoeaai? ?aaani?aoe?? iaai?th a oiiaao iaaaioaaeaiiy. Aeei?enoaaoe e?euee?ni? e?eoa??? ioe?iee a?aae??iocaeaaeiiai ? aeoeaiiai o?ainii?oo iaai?th, iaie aeyaeaii o oai?eo ia AA i?enei?aiiy ianeaiiai a?aae??ioiiai o?ainii?oo, oiio ui eiao?oe??io ?aa?an?? a ??aiyii?, ui oa?aeoa?eco? i?yiie?i?eio caeaaei?noue i?ae i?e?inoii AO iaai?th ? eiai OC a i?ioean? IOO (0,34) o ieo ieae/a, i?ae o caei?iaeo (0,41). Aeoeaiee eaiaeueoeaaee o?ainii?o iaai?th cae?enith?oueny i?ae eiio?ieai IOA ia?aaaaeii a aeenoaeueiiio eaiaeueoe? iao?iia. O oai?eo ia AA aeoeaiee o?ainii?o iaai?th oiia?eueiaiee, i?i ui na?ae/eoue iaioee i?e??no o ieo AO i?e OC, ??aiiio 0. Ei?aeyoe?eii-?aa?an?eiee aiae?c iieacaa, ui o?niioa ca'yceo i?ae c?ooaiiyie IOA ? i?e?inoii AO iaai?th a i?ioean? IOO o oai?eo ia AA (r=-0,48) iaeaea aaea?/? iaioa, i?ae o caei?iaeo (r=-0,79; p<0,05), oiaoi ie?ee oai?eo ia AA iaioa /ooeea? aei aieeao IOA. Oaeo cieaeaii? /ooeeaino? ie?ie i?e AA aei ai?iiiaeueieo noeioe?a i?aeoaa?aeaeaiee iaoeie aeine?aeaeaiiyie c aaaaeaiiyi aeciaaiiiai IOA: o oai?eo ia AA iaai?eo?aoe/ia ?aaeoe?y ie?ie iaio ae?aaeaia ? ianooia? i?ci?oa (oaae. 2). O caei?iaeo i?e??no ie?eiai? aene?aoe?? iaai?th a?aecia/a?oueny aaea /a?ac 3 aiaeeie i?ney aaaaeaiiy ia?aoai?iiia, o oai?eo - o?eueee /a?ac 6 aiaeei, a eiai ?ici?? i?eaeecii a 2,5 ?ace iaioa. C?inoaiiy o oai?eo ia AA AO i?e i?i?iaeueiiio c?ooaii? OC (OC=0) na?ae/eoue i?i ciaioaiiy ?ioaineaiino? aeoeaiiai eaiaeueoeaaiai o?ainii?oo iaai?th, oiaoi i?i cieaeaiiy /ooeeaino? ie?eiaeo eaiaeueoe?a aei aieeao IOA. I?ney ia?i?aeueiiai i?eeiio iaaaioaaeaiiy iaai?e oeyoii eeoeiai? aani?aoe?? ii/eia? iaaeoiaeeoe a iicaee?oeiiee naeoi?. Noaoenoe/ii aeinoia??iee i?e??no iaai??i?? aoa a?aecia/aiee ia 60-e oaeeei?, eiee a caei?iaeo a?i neeaa 0,046±0,07 iiieue/e. Ia 90-o oaeeeio i?e??no iaai??i?? iaaeeaeaany aei iaeneiaeueiiai - 0,11-0,23, o na?aaeiueiio 0,18±0,01. Ia 120-o oaeeeio i?e??no caeeoaany iaeaea oaeei aea ? neeaaeaa 0,14-0,27 iiieue/e, o na?aaeiueiio 0,21±0,01 iiieue/e. Ae?aci?noue iaaaioaaeoaaeueii? a?ia?iaai??i?? i?ney ia?i?aeueiiai i?eeiio iaai?th ? oa?i?ie ?? aeieeiaiiy aecia/athoueny ni?aa?aeiioaiiyi i?ioeeaaeii ni?yiiaaieo i?ioean?a: iaaeoiaeaeaiiyi aani?aiaaiiai a eeoeao iaai?th a iicaee?oeiio ??aeeio ? aeaeaeaiiyi eiai a?aeo?ey oeyoii ie?eiai? aene?aoe??, eeoeiai? nae?aoe??, ia?aoiaeo a ?io? iai?ii? naeoi?e (e?noee, ee?oeie) i?ae aieeaii ai?iii?a - IOA ? EO. Eeoeiaa aani?aoe?y iaai?th a ethaeeie iaei aea/aia /a?ac a?aenooi?noue aaeaeaaoieo iaoiae?a aeine?aeaeaiiy. Ie ai?iaoaaee i?ea?iaeueiee iaoiae ioe?iee ?ioaineaiino? eeoeiai? aani?aoe?? iaai?th a ethaeeie, i?eaeaoiee aeey ee?i?/iiai aeei?enoaiiy. Ni?yiiaai?noue c?ooaiue iaai??i?? i?ney ia?i?aeueiiai i?eeiio iaai?th o aea/ai? ?ioa?aaee /ano o oai?eo ia AA oa ae, ui ? a eiio?ieuei?e a?oi?, iaeiae e?eaa ?? ia?inoaiiy ia? a?eueo iieiaeenoee aeae. Oaeaee?noue ia?inoaiiy iaai??i?? iii?oii a?aenoa? a?ae iieaciee?a o caei?iaeo aei 90-e oaeeeie i?ney i?eeiio iaaaioaaeaiiy. I?ae 90-e ? 120-e oaeeeiaie iaai??i?y i?iaeiaaeo? ia?inoaoe a?eueo cia/ii, i?ae o caei?iaeo in?a. Iaeiae i?e??no eiioeaio?aoe?? ?ii?ciaaiiai iaai?th aei 120-e oaeeeie o oai?eo ia AA iaioee, i?ae o caei?iaeo (oaae. 2). Oaaeeoey 2 IIEACIEEE IAOAAIE?CIO IAAI?TH A CAeI?IAEO IN?A ? OAI?EO IA AA Iieacieee iaoaaie?cio iaai?thCaei?ia?Oai?? AA Ne?iaaoea e?ia?: Caaaeueiee iaai?e, iiieue/e ?ii?ciaaiee iaai?e, iiieue/e IOA, ia/ie EO, ia/ie 1,25(II)2Ae3, ia/ie OAIMg++, ieiieue/ e/oa 0,98±0,02 0,56±0,01 69,8±6,8 12,7±0,8 35,1±1,8 1,76±0,01 0,98±0,02 0,58±0,01 119,1±7,2 * 17,5±1,6 * 28,7±1,5 * 0,86±0,06 * A?eo?ioeeoe: Iaai?e, iiieue/e Eaeueoe?e, iiieue/e Mg/Ca a?eo?ioeeo?a Mg ne?iaaoee/Ca a?eo?ioeeo?a Niiaeeaaiiy iaai?th, ia/24 a 1,52±0,02 1,14±0,02 1,33±0,06 0,49±0,02 524±38 1,38±0,02 * 1,31±0,04 * 1,05±0,08 * 0,44±0.01 * 313±30 * Eeoee: Oaeaee?noue aani?aoe??, iiieue/oa. Iaaaioaaeaiiy ieneaeaa?oii 1,75±0,03 +0,26±0,01 1,33±0,02 * +0,17±0,01 * E?noee: O?ainii?o ?c iicaee?oeiii? ??aeeie, iiieue/e Iaaaioaaeaiiy iaai??i Iaaaioaaeaiiy IOA -0,054±0,007 +0,157±0,005 -0,094±0,010 -0,076±0,004* +0,141±0,004* -0,064±0,002 * Ie?ee: Aene?aoe?y iaai?th, iiieue/24 a 5,7±0,6 3,9±0,4 *Iaaaioaaeaiiy iaai??i: Aene?aoe?y iaai?th, ieiieue/oa OC iaai?th, ieiieue/oa AO iaai?th, % +8,12±0,31 +17,3±1,2 +9,39±0,91 +3,64±0,19 * +17,9±1,2 +6,72±0,47 * Iaaaioaaeaiiy IOA: Aene?aoe?y iaai?th, ieiieue/oa OC iaai?th, ieiieue/oa AO iaai?th, % +2,96±0,17 +10,0±1,4 -10,4±0,8 +2,29±0,22 * +7,3±1,1* -10,4±0,8 I?ei?oea.* - Noaoenoe/ii aeinoia??ii a ii??aiyii? c? caei?iaeie (p<0,01). Aeei?enoiaoth/e aea/aiiy aeeiai?ee iaai??i?? a o? nai? oei/ania? ia??iaee i?ney ia?i?aeueiiai i?eeiio iaai?th ? i?ney eiai aioo??oiueiaaiiiai aaaaeaiiy a aea?aaeaioi?e aeic?, eiee iia?e?cothoueny o? nai? ?aaoeyoi?i? iaoai?cie aiiainoaco, ni?yiiaai? ia aeaeaeaiiy iaaeeeoeo iaai?th c iicaee?oeiii? ??aeeie, ie aecia/eee ?ici?? aaniethoii? eeoeiai? aani?aoe?? ye noio i?e?inoo ai?noo iaai?th a iicaee?oeii?e ??aeei? i?ney ia?i?aeueiiai aaaaeaiiy ? cieaeaiiy ai?noo iaai?th a iicaee?oeii?e ??aeei? i?ney aioo??oiueiaaiiiai aaaaeaiiy. Eeoeiaa aani?aoe?y iaai?th neeaea a caei?iaeo 5,53±0,32 iiieue, ui neeaaea? 79,0 % a?ae ia?i?aeueiiai iaaaioaaeaiiy. O oai?eo ia AA eeoeiaa aani?aoe?y iaai?th neeaea 4,17±0,27 iiieue (p<0,01), oiaoi 47,4% oaaaeaiiai iaaaioaaeaiiy. O?ainii?o iaai?th a eeoiaiee cae?enith?oueny ca aeiiiiiaith a?oai?i Ae-iacaeaaeii? ianeaii? aeeooc?? ? oeyoii aeoeaiiai a?oai?i Ae-caeaaeiiai i?ioeano. Ca aeiiiiiaith eo?niaiai iaaaioaaeaiiy ieneaeaa?oii ie ioe?ieee a?oai?i Ae-caeaaeiee eeoeiaee o?ainii?o iaai?th. O caei?iaeo ianoaaeaieo ? o oai?eo ia AA i?ney eo?niaiai i?ecia/aiiy ieneaeaa?oa aacaeueiee ??aaiue iaaaioaaeoaaeueii? iaai??i?? ca?eueoo?oueny, aea o oai?eo ia AA - o iaioiio nooiai?, ui na?ae/eoue i?i iaioee aieea a?oai?io Ae3 ia eeoeiao aani?aoe?th iaai?th o oai?eo ia AA. Aeey ioe?iee ianeaii? aeeooc?? iaie aea/aiee aieea i?ieiiaiaaiiai 5-aeaiiiai i?eeiio iaai?th ia ?ioaineai?noue eiai eeoeiai? aani?aoe??. O oai?eo ia AA i?e??no ??aiy iaaaioaaeoaaeueii? iaai??i?? i?ney i?ieiiaiaaiiai i?eeiio iaai?th a?eueo ae?aaeaiee, i?ae o caei?iaeo. I/aaeaeii, ui ianeaia aeeooc?y o oai?eo ia AA a?eueo ae?aaeaia, i?ae o caei?iaeo. sseui a caei?iaeo e?euee?noue iaai?th, ui o?ainii?oo?oueny i?ae ie?eiaei naeoi?ii ? iicaee?oeiiith ??aeeiith, aei??aith? e?eueeino? iaai?th, ui o?ainii?oo?oueny i?ae e?noeiaei naeoi?ii ? iicaee?oeiiith ??aeeiith, oi o oai?eo ia AA ?ioaineai?noue o?ainii?oo iaai?th i?ae iicaee?oeiiei ? e?noeiaei naeoi?aie ?noioii i?aeaeuaia, ui na?ae/eoue i?i ia?aaaaeaiiy o oai?eo ia AA i?ioeano ?aci?aoe?? iaai?th c e?noeiai? oeaieie (oaae. 2). A oiiaao aioo??oiueiaaiiiai iaaaioaaeaiiy iaai??i o ianoaaeaieo in?a ci?ith?oueny iai?yiie o?ainii?oo iaai?th - iaai?e aeeo/a?oueny c iicaee?oeiiiai naeoi?a: aeaiaeeoueny ie?eaie aiane?aeie i?eai?/aiiy eaiaeueoeaai? ?aaani?aoe?? ? iiaeeia?oueny e?noeith aiane?aeie oiia?eueiaiiy ?aci?aoe?? iaai?th c e?noeiai? oeaieie. Aoaeoeai?noue iiaeeiaiiy i?ney iaaaioaaeaiiy iaaeeeoeo ?ii?a iaai?th e?noeiaith oeaieiith c iicaee?oeiiiai naeoi?a o oai?eo ia AA iaioa a ii??aiyii? c? caei?iaeie ethaeueie. Oiia?eueiaiiy aeaaaeaiiy iaaaioaaeoaaeueiiai iaai?th c iicaee?oeiii? ??aeeie o oai?eo ia AA iaoiiaeaii a a?eueoiio nooiai? ii?ooaiiyi o?ainii?oo a e?noeiaee naeoi?, i?ae o ie?eiaee. I?e/eiith oiia?eueiaiiai aeaaaeaiiy iaai?th c iicaee?oeiii? ??aeeie a e?noeiaee naeoi? ? cieaeaiiy /ooeeaino? inoaieeano?a aei aieeao IOA. O caei?iaeo ?aaeoe?y e?noeiai? oeaieie (-0,094±0,010) ia aaaaeaiiy IOA cia/ii a?eueo ae?aaeaia, i?ae ie?ie (+0,076±0,009 iiieue/e). Ioaea, iniiaiee i?yiee aoaeo IOA ?aae?co?oueny /a?ac aieea ia ee?oeie e?noeiai? oeaieie. Iaaooue, i?yiee aieea IOA ia ie?ee caianeiaaii aeieeath/ith a?ia?iaai??i??th, ui i?ioeae?? ?ioaineo?eaoe?? IOA eaiaeueoeaai? ?aaani?aoe?? iaai?th. O oai?eo ia AA aaaaeaiiy IOA noi?iaiaeaeoaaeiny iaioei iiaeeiaiiyi iicaee?oeiiiai iaai?th e?noeiaith oeaieiith (-0,064±0,002 iiieue/e; p<0,001), na?ae/a/e i?i cieaeaiiy /ooeeaino? aoaeoi?ieo i?aai?a iaoaaie?cio iaai?th aei ?aaoethth/iai aieeao ai?iii?a. I?e/eiith oeueiai cieaeaiiy iiaeooue aooe o?iaeaeai? aeaoaeoe ia ??ai? aeeiiaa/eo i?aai?a, a oaeiae cieaeaiiy ?oiuei? /ooeeaino? aei ai?iiiaeueieo noeioe?a oiane?aeie iino?eii? iaaeeeoeiai? noeioeyoe?? ai?iiiaie, ye? i?iaeoeothoueny o iaaeeeoeo. Onoaiiaeoe cia/aiiy oeeo i?e/ei iiaeia oeyoii ioe?iee iiaeeeaino? ei?aeoe?? iienaieo a?aeoeeaiue o iaoaaie?ci? iaai?th. Ai?iiiaeueia ?aaoeyoe?y aiiainoaco iaai?th i?e anaioe?aeuei?e a?ia?oaic??. Eiioeaio?aoe?y IOA a ieaci? e?ia? oai?eo ia AA (119,1±7,2 ia/ie) iaeaea aaea?/? (p<0,01) ia?aaeuoaaea eiai eiioeaio?aoe?th a ieaci? e?ia? caei?iaeo (69,8±6,8 ia/ie). Eiioeaio?aoe?y EO o ieaci? e?ia? a caei?iaeo in?a (12,7±0,8 ia/ie) ? o oai?eo ia AA (17,5±1,6 ia/ie) oaeiae a?ae??ciy?oueny (p<0,05). Eiioeaio?aoe?y 1,25(II)2Ae3 o ieaci? e?ia? o oai?eo ia AA (28,7±1,5 ia/ie) ieae/a, i?ae o caei?iaeo ianoaaeaieo (35,1±1,8 ia/ie; p<0,05). Iniiaieie ?aaoeyoi?aie nae?aoe?? IOA, EO ? a?oai?io Ae3 ? ?iie eaeueoe?th ?, o iaioiio nooiai?, iaai?th a ne?iaaooe? e?ia?. ?oiy eiioeaio?aoe?y a caei?iaeo ? oai?eo ia AA ia a?ae??ciy?oueny. Ioaea, c?ooaiiy eiioeaio?aoe?? ai?iii?a, ui aeieeathoue o oai?eo ia AA, aoaeoeaii oo?eiothoue eiioeaio?aoe?th ?ii?a eaeueoe?th ? iaai?th a iicaee?oeii?e ??aeei? ia ii?iaeueiiio ??ai?. Aea a?aeoeeaiiy a?ae ii?ie eiioeaio?aoe?? ai?iii?a na?ae/aoue i?i oa, ui eiioeaio?aoe?y ?ii?a eaeueoe?th aai iaai?th a iicaee?oeii?e ??aeei? cieaeo?oueny, iaaooue, oiane?aeie cieaeaiiy eeoeiai? aani?aoe??. O i?aeo?eioe? ??aiy iaai??i?? i?ney aaaaeaiiy aeiaeaoeiaiai iaai?th a iicaee?oeiiee naeoi?, oiaoi a e?ia (aioo??oiueiaaiiee IOO) aa?ooue o/anoue on? ?aaoethth/? ai?iiie, aea a iniiaiiio IOA ? EO (cia/aiiy a?oai?io Ae3 cia/ii iaioa, ine?eueee eiai iniiaiei i?noeai ae?? ? eeoiaiee). Oe?eue oeueiai i?ioeano - e?ea?aeaoe?y iaaaioaaeoaaeueii? a?ia?iaai??i??. Oaeei /eiii, IOO aeicaiey? iaea?aeaoe ocaaaeueiaio e?euee?nio oa?aeoa?enoeeo ooieoe?iiaeueiiai noaio iaai?e?aaoethth/eo nenoai. Oeoeooaoe?y ai?iiiaeueiiai noaoono ianooia? aeoaea oaeaeei. O an?o caei?iaeo ia 20-e oaeeei? IOO eiioeaio?aoe?y IOA ?noioii cieceeany, o na?aaeiueiio ia 24,7±2,6 ia/ie. Eiioeaio?aoe?y EO ?noioii c?inea, o na?aaeiueiio ia 16,67±1,8 ia/ie. Nooi?iue ?aa?an?eii? caeaaeiino? i?ae i?e?inoii eiioeaio?aoe?? ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia? ? c?ooaiiyie IOA ? EO, ui aeieeathoue o a?aeiia?aeue ia i?aeaeuaiiy ??aiy iaai??i?? a caei?iaeo in?a, aeoaea neaaea, o oai?eo ia AA aiia aeoaea ae?aaeaia - eiao?oe??io ei?aeyoe?? -0,733. Oea iiaeia iiynieoe a?eueoith aioiai?noth ia?aueoiaeaeieo caeic oai?eo ia AA ?aaaoaaoe ia ci?ie ??aiy iaai?th a e?ia?, iiaeeeai, oiane?aeie iino?eii? ianoa/? iaai?th a i?aai?ci? oai?eo. Caeaaei?noue ci?i ??aiy EO a?ae eieeaaiue iaai??i?? o oai?eo AA (eiao?oe??io ei?aeyoe?? r=0,232) aeineoue neaaea, ui a?aeiia?aea? iae?e ?ie? EO. Ci?ie eiioeaio?aoe?? ai?iii?a o a?aeiia?aeue ia a?ia?iaai??i?th a ia?o? 20 oaeeei IOO ca i?eioeeiii iaaaoeaiiai cai?ioiiai ca'yceo aecia/athoue ianooiio aeeiai?eo i?ioeano e?ea?aeaoe?? iaaaioaaeoaaeueii? iaai??i??. Ia 20-e oaeeei? IOO ca'ycie i?ae oeeie o?c?ieia?/ieie i?ioeanaie a?eueo o?niee a caei?iaeo ethaeae - eiao?oe??io ?aa?an?? 0,621, i?ae o oai?eo ia AA - eiao?oe??io ?aa?an?? 0,362; p<0,05. Iacaaaeath/e ia aaeee? c?ooaiiy ai?iii?a, aoaeoeai?noue ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i?? o oai?eo ia AA iaioa, i?ae o caei?iaeo. Aiiainoac iaai?th ? aioea?ia?oaiceaia oa?ai?y o oai?eo ia anaioe?aeueio a?ia?oaic?th. Aoaeoeaiei aaaaeaee e?eoaaiiy, i?e yeiio aeinyaaee cieaeaiiy ??aiy ae?anoie?/iiai AO i?i?ioi ia 10 % a?ae aeo?aeiiai ??aiy. Iniiai? iieacieee iaoaaie?cio iaai?th o oai?eo ia AA iaaaaeai? a oaae. 2. Aea/aiiy noaio iaoaaie?cio iaai?th o oai?eo ia AA aeicaieeei i?iaiicoaaoe aoaeoeai?noue e?eoaaiiy ?ia?a?oi?aie AIO. Aeniea aoaeoeai?noue e?eoaaiiy ?ia?a?oi?aie AIO i/?eo?oueny i?e ii?iaeuei?e aacaeuei?e eiioeaio?aoe?? ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia? (ia iaioa 0,52 iiieue/e) ? a a?eo?ioeeoao (ia iaioa 1,40 iiieue/e), i?e aenie?e OAIMg++ (ia iaioa 1,40 ieiieue/e/oa), i?e ii?iaeuei?e eiioeaio?aoe?? IOA (ia a?eueoa 96 ia/ie) ? EO (ia a?eueoa 13 ia/ie) o ieaci? e?ia?. I?ecia/aiiy ?ia?a?oi?o AIO iaaeioe?eueii i?e aacaeuei?e eiioeaio?aoe?? ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia? iaioa 0,52 iiieue/e/oa, a a?eo?ioeeoao - iaioa 1,26 iiieue/e, i?e ciaioaii? OAIMg++ ieae/a 0,40 ieiieue/e/oa, i?e i?aeaeuaii? eiioeaio?aoe?? IOA aeua 118 ia/ie ? eiioeaio?aoe?? EO aeua 32,4 ia/ie. Aoaeoeai?noue e?eoaaiiy aioaaii?noaie eaeueoe?th ia caeaaeaea a?ae aacaeueiiai ??aiy iaai??i??, oaeiae ye ? a?ae ?? aeeiai?ee a i?ioean? IOO. Oaeaee?noue eeoeiai? aani?aoe?? iaai?th (OEAMg) o oai?eo, ui iaea?aeoaaee aioaaii?noe eaeueoe?th, aoea ??aiii??ii cieaeaia o an?o a?oiao iacaeaaeii a?ae aoaeoeaiino? e?eoaaiiy a ii??aiyii? c? caei?iaeie. Iaea?eueoa aoaeoeai?noue e?eoaaiiy aioaaii?noaie eaeueoe?th niinoa??aaeany o oai?eo ?c iecueeith aioo??oiueiee?oeiiith eiioeaio?aoe??th iaai?th, i?i ui na?ae/eoue noaoenoe/ii aeinoia??ii iaioa eiioeaio?aoe?y iaai?th a a?eo?ioeeoao o oai?eo ?c aenieith aoaeoeai?noth e?eoaaiiy (1,25±0,02). Aea a a?oiao ?c na?aaeiueith (1,33±0,03) ? iecueeith (1,42±0,02) aoaeoeai?noth e?eoaaiiy eiioeaio?aoe?y iaai?th a a?eo?ioeeoao noaoenoe/ii aeinoia??ii ieae/a, i?ae o a?oi? c a?aenooi?noth aoaeoo a?ae e?eoaaiiy (1,48±0,02; p<0,05). A?aenooi?noue ?icoiaeaeaiue o iicaee?oeii?e eiioeaio?aoe?? iaai?th ? o OAIMg++ i?aeoaa?aeaeo? aenieo ni?iiiaei?noue aiiainoaco ?aaoethaaoe iicaee?oeiio eiioeaio?aoe?th iaai?th, /iio, iiaeeeai, ni?ey? i?aeaeuaia i?iaeoeoe?y ?aaoethth/eo ai?iii?a. Ieaciaiia eiioeaio?aoe?y IOA o an?o a?oiao c aoaeoeaiei e?eoaaiiyi aioaaii?noaie eaeueoe?th ia?aaeuoaaea eiioeaio?aoe?th ai?iiio a a?oi? c a?aenooi?noth aoaeoo a?ae ieo. Iaeiia??i?oa onueiai, ui i?aeaeuaiiy eiioeaio?aoe?? IOA iaoiiaeaii noiooi?i ii?ooaiiyi iai?io eaeueoe?th, ui i?ecaiaeeoue aei iaeiie/aiiy ?ii?a eaeueoe?th a ee?oeiao, ui oaeiae anioe?th?oueny c i?aeaeuaiiyi aoaeoeaiino? e?eoaaiiy aioaaii?noaie eaeueoe?th. I?ecia/aiiy aioaaii?no?a eaeueoe?th iaea?eueoa aei?aaaeaii oai?ei AA, o yeeo eiioeaio?aoe?y ?ii?ciaaiiai iaai?th ia a?aeiiaeth?oueny i?ney ia?i?aeueiiai iaaaioaaeaiiy iaai??i o i?ioean? IOO, i?aeaeuaia eiioeaio?aoe?y IOA o ieaci? e?ia? ? cieaeaia eiioeaio?aoe?y aioo??oiueia?eo?ioeeoa?iiai iaai?th. Aacaeueia eiioeaio?aoe?y ?ii?ciaaiiai iaai?th o oai?eo ia AA, o yeeo e?eoaaiiy aaoa-aae?aiiaeieaoi?aie a?ae??ciyeiny ii nooiai? aoaeoeaiino?, o na?aaeiueiio noaoenoe/ii aeinoia??ieo a?aei?iiinoae ia iaea a aeiaei?e c ianoaaeaieo a?oi oai?eo ia AA. Aeeiai?ea ??aiy iaai??i?? i?ney ia?i?aeueiiai iaaaioaaeaiiy iaai??i o oai?eo ia AA ?c ??ciith aoaeoeai?noth e?eoaaiiy aaoa-aae?aiiaeieaoi?aie aoaeue-ne?eueee ?noioii ia a?ae??ciyeany. O oai?eo ia AA, ui iaea?aeoaaee aaoa-aae?aiiaeieaoi?e OEAMg aoea ??aiii??ii cieaeaia o an?o a?oiao oai?eo ia AA o ii??aiyii? c? caei?iaeie. Eiioeaio?aoe?y IOA a ??cieo ii aoaeoeaiino? e?eoaaiiy a?oiao oai?eo ia AA aoea i?aeoe/ii iaeiaeiaith. Oaeei /eiii, nooi?iue aoaeoeaiino? e?eoaaiiy aaoa-aae?aiiaeieaoi?aie ia caeaaeeoue a?ae noaio iaoaaie?cio iaai?th. I?e aeai?? aioea?ia?oaiceaiiai i?aia?aoo ia?aaaao i?e i?ecia/aii? aaoa-aae?aiiaeieaoi??a oai?ei AA aa?oi a?aeaeaaaoe i?e a?aeiia?aeieo aaiiaeeiaie/ieo oa?aeoa?enoeeao, cie?aia i?e iayaiino? oaiaeaioe?? aei oao?ea?ae??, ia ea?oth/enue i?e oeueiio iieacieeaie noaio iaoaaie?cio iaai?th. Na?aaei? aacaeuei? eiioeaio?aoe?? ?ii?ciaaiiai iaai?th o oai?eo ia AA, o yeeo e?eoaaiiy o?aceaeiei ae?o?aoeeii a?ae??ciyeiny ii aoaeoeaiino?, noaoenoe/ii aeinoia??ii ia ?ic??ciyeeny. I?e??no eiioeaio?aoe?? ?ii?ciaaiiai iaai?th i?ney ia?i?aeueiiai iaaaioaaeaiiy iaai??i o a?oiao ?c ??ciith aoaeoeai?noth e?eoaaiiy ae?o?aoeeii aoa iaeiaeiaei, oi/a ? iaioei, i?ae o caei?iaeo in?a. Cieaeaiiy ??aiy iaaaioaaeoaaeueii? iaai??i?? a a?oiao oai?eo ia AA aoei iaaaeaeaaoii iecueeei o oai?eo ?c iecueeith aoaeoeai?noth e?eoaaiiy ae?o?aoeeii ? c a?aenooi?noth aoaeoo a?ae e?eoaaiiy. A ?acoeueoao? o oai?eo oeeo a?oi eiioeaio?aoe?y ?ii?ciaaiiai iaai?th /a?ac 240 oaeeei i?ney ia?i?aeueiiai iaaaioaaeaiiy iaai??i ia a?aeiiaeeany aei aeo?aeii? ia a?aei?io a?ae iieacieea a a?oiao ?c aenieith ? na?aaeiueith aoaeoeai?noth e?eoaaiiy. O oai?eo ?c a?aenooi?noth aoaeoo a?ae e?eoaaiiy ae?oeio?aceaeii OEAMg noaoenoe/ii aeinoia??ii ieae/a, i?ae o oai?eo c aoaeoeaiei e?eoaaiiyi oeei i?aia?aoii. ?acoeueoaoii cieaeaiiai iaaeoiaeaeaiiy iaai?th c eeoie o iicaee?oeiiee naeoi? ? cieaeaiiy OAIMg++ o oai?eo ?c iecueeith aoaeoeai?noth e?eoaaiiy ae?o?aoeeii ? c a?aenooi?noth aoaeoo a?ae e?eoaaiiy i?aia?aoii. Aaeaeaaoia ae?i?iaoe?y iaaaioaaeoaaeueii? iaai??i?? cae?enith?oueny eeoa o oai?eo ?c aenieith ? na?aaeiueith aoaeoeai?noth e?eoaaiiy ae?o?aoeeii. A a?oi? oai?eo ?c a?aenooi?noth aoaeoo a?ae e?eoaaiiy ae?o?aoeeii OAIMg++ noaoenoe/ii aeinoia??ii iaioa, i?ae o an?o ?ioeo a?oiao oai?eo. I?e ciaioaii? OAIMg++ ieae/a 0,85 ieiieue/e/oa oa?ai?y ae?oeio?aceaeii aoea iaaoaeoeaia. Ie ia aeyaeee a?aeoeeaiue a?ae ii?iaeueiiai ??aiy ieaciaiii? eiioeaio?aoe?? IOA ? EO. Iaaiaee, naia o oai?eo ?c aenieith aoaeoeai?noth e?eoaaiiy eiioeaio?aoe?y ai?iii?a iii?oii i?aeaeuaia. Eiioeaio?aoe?y iaai?th a a?eo?ioeeoao oai?eo ia AA c aoaeoeaiith iiiioa?ai??th o?aceaeiei ae?o?aoeeii i?aeoe/ii ia a?ae??ciy?oueny a?ae iieaciee?a a ianoaaeaieo caei?iaeo in?a. O oai?eo ia AA ?c a?aenooi?noth aoaeoo a?ae iiiioa?ai?? ae?oeio?aceaeii eiioeaio?aoe?y iaai?th a a?eo?ioeeoao cia/ii ieae/a. Oaeei /eiii, i?e aeao?oeeo? iaai?th a i?aai?ci? ia o?eueee aioo??oiueiee?oeiiiio, aea ? iicaee?oeiiiio iiiioa?ai?y o?aceaeiei ae?o?aoeeii aeyaey?oueny iaaoaeoeaiith. Ni?aa?aeiioaiiy ie?eiaiai o?ainii?oo iaai?th ? eaeueoe?th o oai?eo ia AA. Aiae?c ni?aa?aeiioaiiy aene?aoe?? eaeueoe?th ? iaai?th a oiiaao eaeueoe?e- ? IOO iieacaa iii?oia ia?aaaaeaiiy i?ney nieueiaiai iaaaioaaeaiiy o oai?eo ia AA aene?aoe?? iaai?th. Ine?eueee OC eaeueoe?th ? iaai?th aiane?aeie iaaaioaaeaiue ci?ithaaany iaeiaeiai a caei?iaeo ? oai?eo ia AA, ynii, ui cieaeaiiy eaeueoe?e- ? iaai?eo?aoe/ii? ooieoe?? ie?ie iaoiiaeaii ii?ooaiiyi eaiaeueoeaaiai o?ainii?oo eao?ii?a, a ia ?oiueith eeoai/eiaith o?eueo?aoe??th. Eaiaeueoeaaee o?ainii?o eaeueoe?th ? /anoeiai a?aae??iocaeaaeiei (o caeoiio a?aeae?e? i?ieneiaeueiiai eaiaeueoey ? a oianoiio a?aeae?e? aeno?aeiiai eie?ia iaoe? Aaiea) ? /anoeiai - aeoeaiei (ia?aaaaeii a caeoiio aeenoaeueiiio eaiaeueoe?). O oai?eo ia AA ?ioaineai?noue a?aae??iocaeaaeii? eaiaeueoeaai? ?aaani?aoe?? c?inoa?. Eiao?oe??io ?aa?an?? aeey eaeueoe?th neeaaea? a caei?iaeo ianoaaeaieo 0,47, o oai?eo 0,42, ui na?ae/eoue i?i i?enei?aiiy a?aae??iocaeaaeiiai o?ainii?oo o oai?eo ia AA. Iaea?eueo eiia??iith i?e/eiith oeueiai i?aaenoaaey?oueny ii?ooaiiy iao??e-eaeueoe??aiai iai?io. O caei?iaeo ianoaaeaieo eiao?oe??io ?aa?an?? aeey iaai?th neeaaea? 0,41, ui a?aeiia?aea? aeineoue aenieiio ??aith eiai a?aae??ioiiai o?ainii?oo, ui ia 60 % ?aaani?a??o?oueny ii a?aae??ioo eiioeaio?aoe?? c i?ina?oo eaiaeueoey /a?ac ethi?iaeueio iaia?aio ana?aaeeio ee?oeie. O oai?eo ia AA (eiao?oe??io ?aa?an?? 0,34 - ieae/a, i?ae o caei?iaeo in?a) a?aae??ioiee o?ainii?o i?enei?aiee, ye ? aeoeaiee (iaioee i?e??no AO i?e OC, ??aiiio 0), ia iaoo aeoieo, /a?ac aeao?oeeo eiai aioo??oiueiee?oeiiiai ai?noo. C iaeyaeo ia oa, ui eaiaeueoeaaa ?aaani?aoe?y eaeueoe?th ? iaai?th ?aaoeth?oueny ia?aaaaeii IOA, iaie i?iaiae?ciaaia aeeiai?ea IOA o i?ioean? i?iaaaeaiiy eaeueoe?e- ? iaai?eoiea?aioieo oano?a. O oai?eo ia AA i?eai?/aiiy nae?aoe?? IOA o a?aeiia?aeue ia iaaaioaaeaiiy eaeueoe??i ? iaai??i aoei a?eueo ae?aaeaiei. Iaeiae ei?aeyoe?eii-?aa?an?eiee aiae?c iieacaa, ui o?niioa ca'yceo i?ae c?ooaiiyie IOA ? i?e?inoii AO eaeueoe?th (r=0,559) ? iaai?th (r=0,480) o i?ioean? oiea?aioieo oano?a o oai?eo ia AA iaeaea aaea?/? iaioa, i?ae o caei?iaeo ianoaaeaieo (a?aeiia?aeii aeey eaeueoe?th r=0,934 ? iaai?th r=-0,79; p<0,01), oiaoi ie?ee oai?eo ia AA iaioa /ooeea? aei aieeao IOA. Oaeei /eiii, a oiiaao iaaaioaaeaiue (eaeueoe?e, iaai?e, ai?iiie, ae?o?aoeee), eiee ?ioaineo?eo?oueny eaiaeueoeaaee o?ainii?o eaeueoe?th ? iaai?th, aene?aoe?y iaai?th c?inoa? a a?eueo?e i???, i?ae aene?aoe?y eaeueoe?th, oiaoi ie?ee oai?eo ia AA o neooaoe?yo, eiee iiaeiia aooe ca?eueoaia aene?aoe?y iaio eao?ii?a, nei??oa ao?a/athoue iaai?e ? a iaioiio nooiai? ao?a/athoue eaeueoe?e ca ?aooiie a?eueo noai?i? ai?iiiaeueii? ?aaoeyoe?? eiai aeoeaiiai eaiaeueoeaaiai o?ainii?oo. Iaai?e o a?eueoino? aeiaaee?a aeeiio? i?aeii?yaeeiaaia noiniaii eaeueoe?th cia/aiiy ? iaio niaoeeo?/ii ?aaoeth?oueny ai?iiiaie. Iao? aeai? aeicaieythoue i?eionoeoe, ui oeae “ie?eiaee aeaoaeo” aeey iaai?th ? iaeiei ?c iaoiaaiaoe/ieo iaoai?ci?a oi?ioaaiiy AA, oiio ui aaaea aei ca?eueoaiiy iaai??aiai aeao?oeeoo a i?aai?ci?, o o./. o ee?oeiao aeaaeeeo i'yc?a noaeei. Iaoeaa? ae?o?aoeee ciaioothoue ?aaani?aoe?th eaeueoe?th o?eueee a iiceiaiio naaiaio? ? aeeeeeathoue cia/io iaai?eo?eth, i?eai?/oth/e ?aaani?aoe?th iaai?th a oianoiio aeno?aeiiio eie?i? iaoe? Aaiea. O?aceaei? ae?o?aoeee iathoue a?iieaeueoe?eo?aoe/iee aoaeo ? iaai?eo?aoe/iee, i?eai?/oth/e i?ieneiaeueio ?aaani?aoe?th iaai?th. Oaeei /eiii, i?e i?eeii? iaoeaaeo ? o?aceaeieo ae?o?aoee?a o oai?eo ia AA ?c aeaio eao?ii?a o a?eueoiio nooiai? ao?a/a?oueny iaai?e. Oea ni?aa?aeiioaiiy ci?ith?oueny a i?ioeeaaeio noi?iio o?eueee i?e canoinoaaii? eiia?iiaaiiai i?aia?aoo (ai?ei?eae+ae?oeio?aceae) aieo?eaea. Oaeei /eiii, iao? aeine?aeaeaiiy iieacaee, ui ie?ee oai?eo ia AA i?e nieueiaeo, ai?iiiaeueieo ? ae?o?aoe/ieo aieeaao eaaei ao?a/athoue iaai?e, o eiaeiiio aeiaaeeo iaiaaath/enue oo?eiaoe eaeueoe?e, ui, iaaooue, ? aaaeeeaith iaoiaaiaoe/iith eaieith oi?ioaaiiy iaai??aiai aeao?oeeoo c ianooiiei i?aeaeuaiiyi noaeeiiiai iii?o. I/aaeaeii, ui oai?? AA, o ca'yceo c oeei, aeiaaathoue ei?aeoe?? ii?ooaiue iaoaaie?cio iaai?th, iniaeeai ?aoaeueii? i?e canoinoaaii? ae?o?aoe/ii? oa?ai??. Ei?aeoe?y ii?ooaiue aiiainoaco iaai?th ia aoaiao i?io?eaeoeee anaioe?aeueii? a?ia?oaic??. I?e aecia/aii? ae??oe/iiai niiaeeaaiiy iaai?th a in?a ?c ii?iaeueiei ??aiai AO iaie aeyaeaii eiai eieeaaiiy a?ae 171 aei 1077 ia ia aeiao ? na?aaei? cia/aiiy 524±38 ia ia aeiao. A ianoaaeaieo oai?eo ia AA ae??oe/ia niiaeeaaiiy iaai?th aoei cia/ii iaioei. Aiii eieeaaeiny a?ae 149 aei 826 ia o aeiao, neeaaeath/e a na?aaeiueiio 313±30 ia o aeiao (p<0,05). Iae/ano?oa (a?eueo, i?ae o iieiaei? aeiaaee?a) iaeiaioa e?euee?noue niiaeeaaiiai iaai?th - aei 400 ia o aeiao aecia/a?oueny a in?a ?c AA. Aeiaiaa aene?aoe?y iaai?th, ui a?aeia?aaeo? eiai ae??oe/ia niiaeeaaiiy, o oai?eo ia AA (3,9±0,4 iiieue) oaeiae noaoenoe/ii aeinoia??ii (p<0,01) iaioa, i?ae o caei?iaeo ?c ii?iaeueiei ??aiai AO (5,7±0,6 iiieue). Aeey aoaeoeaiiai iiia?aaeaeaiiy AA iioeiaeueiei iiaeia aaaaeaoe aeiaiaa niiaeeaaiiy iaai?th ia iaioa 500 ia. Eiao?oe??io ei?aeyoe?? i?ae ??aiai AO ? niiaeeaaiiyi iaai?th neeaa aeey ae?anoie?/iiai AO - 0,416, aeey nenoie?/iiai AO - 0,333. Ca?eueoaiiy aeiaiaiai niiaeeaaiiy iaai?th oeyoii uiaeaiiiai i?eeiio ania?eaia i?ioyaii 3 i?nyoe?a o aeiaia?e aeic? 0,10 iiieue/ea iane o?ea, ui i?aeoaa?aeaeoaaeiny i?e?inoii aeiaiai? ie?eiai? aene?aoe?? a na?aaeiueiio ia 5,4 iiieue (ia 38,5 %), ia noi?iaiaeaeoaaeiny noaoenoe/ii aeinoia??iith ci?iith ??aiy nenoie?/iiai ? ae?anoie?/iiai AO a in?a ?c AA. Iaeiae o?eaaeee i?eeii ania?eaia iiia?aaeaeaa aenieee c??no AO i?ae /an i?iaaaeaiiy AAI. Aaeeeo aeeiai?eo ia?aoa?ieth? nenoie?/iee AO. Ca?eueoeany /an aeeiiaiiy ?iaioe ia aaeia?aiiao??. Oiaoi na?oeaai-noaeeiia ?aaeoeai?noue cieceeany, a oiea?aioi?noue aei o?ce/iiai iaaaioaaeaiiy c?inea. O i?ioean? o?eaaeiai iaaaioaaeaiiy iaai??i ca?eueoeeeny ae?o?ac, o na?aaeiueiio ia 29,5 %, ? iao??eo?ac - ia 47,7 iiieue/e. Iaie ia aeyaeaii ci?i noaio iaoaaie?cio iaai?th o oai?eo ia AA o i?ioean? e?eoaaiiy ?ia?a?oi?aie AIO. Aacaeueia eiioeaio?aoe?y ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia?, ?ioaineai?noue eeoeiai? aani?aoe?? iaai?th, OAIMg++ i?ney e?eoaaiiy ?ia?a?oi?aie AIO ? eiioeaio?aoe?y iaai?th a a?eo?ioeeoao oai?eo ia AA o i?ioean? e?eoaaiiy ?ia?a?oi?aie AIO i?aeoe/ii ia ci?ieeeny. Ie cai?iiiioaaee /anoei? oai?eo, o yeeo iiiioa?ai?y ?ia?a?oi?ii AIO aoea iaaeinoaoiuei aoaeoeaiith, niieo/eoe ?? c i?eeiiii iaaia-A6 o aeiaia?e aeic? c ?ic?aooieo 0,1 iiieue/ea iaai?th a aeaiue. O a?oi? oai?eo ia AA ?c na?aaeiueith aoaeoeai?noth e?eoaaiiy cia/ii c?inee ? OEAMg, ? OAIMg++ c e?ia?, ui na?ae/eoue i?i a?eueo aeineiiaeo ?aaoeyoe?th iaoaaie?cio iaai?th, ?acoeueoaoii /iai c'yaeeiny ? i?aeaeuaiiy aioo??oiueiee?oeiii? eiioeaio?aoe?? iaai?th. O a?oi? c iecueeith aoaeoeai?noth e?eoaaiiy ?ia?a?oi?ii AIO aeiaeaaaiiy iaai?th oaeiae ni?eyei i?aeaeuaiith OAIMg++. A?aenooi?noue ii?iae?caoe?? aioo??oiueiee?oeiii? eiioeaio?aoe?? iaai?th, iiaeeeai, ? ne?aenoaii iaaeinoaoiuei? o?eaaeino? iaai??aiai iaaaioaaeaiiy. Aeiaeaoeiaee i?eeii iaai?th aeicaieea cieceoe ??aaiue ae?anoie?/iiai AO a a?oi? c iecueeith aoaeoeai?noth e?eoaaiiy ?ia?a?oi?ii AIO ia 7,0±0,8 ii ?o. no, o a?oi? ?c na?aaeiueith aoaeoeai?noth e?eoaaiiy - ia 4,3±0,6 ii ?o.no. Aacaeueia eiioeaio?aoe?y ?ii?ciaaiiai iaai?th o oai?eo ia AA i?ney e?eoaaiiy aioaaii?noaie eaeueoe?th ia a?ae??ciy?oueny a?ae aeo?aeieo aaee/ei aei e?eoaaiiy. I?ney i?eeiio aioaaii?no?a eaeueoe?th OEAMg ia ci?ieeany. I?ney e?eoaaiiy aioaaii?noaie eaeueoe?th OAIMg++ noaoenoe/ii aeinoia??ii cieceeany aiane?aeie oo?aoe iaai?th ie?eaie ? ii?ooaiiy ai?iiiaeueii? ?aaoeyoe??, i?i ui na?ae/eoue i?aeaeuaiiy eiioeaio?aoe?? IOA o ieaci? e?ia?. I?ney aeiaeaoeiaiai i?ecia/aiiy ania?eaia a aeic? 0,1 iiieue/ea iaai?th ia aeiao o oai?eo ia AA o a?oiao ?c na?aaeiueith ? iecueeith aoaeoeai?noth e?eoaaiiy i?e??no eiioeaio?aoe?? ?ii?ciaaiiai iaai?th i?ney ia?i?aeueiiai iaaaioaaeaiiy ia ci?ieany, aea cia/ii c?inea OAIMg++ c e?ia?, ui na?ae/eoue i?i a?eueo aeineiiaeo ?aaoeyoe?th iaoaaie?cio iaai?th, o ?acoeueoao? /iai i?aeaeueeany eiai aioo??oiueiee?oeiia eiioeaio?aoe?y. Oaaeeoey 3 Iieacieee iaoaaie?cio iaai?th o oai?eo ia AA c ??ciith aoaeoeai?noth e?eoaaiiy aioea?ia?oaiceaieie i?aia?aoie (Mm) IieacieeeAoaeoeai?noue e?eoaaiiy Aeniea, n=18 Na?aaeiy, n=21Iecueea, n=6A?aenooiy, n=15?ia?a?oi?e AIOIOA, ia/ie60,46,387,52,3*92,03,0*112,17,05*EO, ia/ie11,80,916,81,2*24,02,9*25,06,5*OEAIg, ieiieue/e/oa11,510,061,240,02*1,230,05*1,080,04*OAIIg++, ieiieue/e/oa1,490,070,580,04*0,500,02*0,420,05*Ig a?eo?ioeeo?a, iiieue/e1,480,021,420,021,340,03* 1,260,01*Aioaaii?noe eaeueoe?yIOA, ia/ie89,13,177,37,279,44,769,74,5*EO, ia/ie 12,72,37,41,58,71,8 6,11,4OEAIg, ieiieue/e/oa1,390,031,350,011,300,061,330,02OAIIg++, ieiieue/e/oa0,890,070,790,060,770,070,750,06Ig a?eo?ioeeo?a, iiieue/e1,250,021,330,03*1,420,02*1,480,02*Aaoa-aae?aiiaeieaoi?eIOA, ia/ie78,95,080,04,076,85,177,75,1 EO, ia/ie 14,71,413,21,212,41,4 7,21,3*OEAIg, ieiieue/e/iei1,340,071,340,041,380,041,440,04OAIIg++, ieiieue/e/iei0,990,100,990,090,920,080,950,06O?aceaeia? ae?o?aoeeeIOA, ia/ie95,72,584,04,277,84,5*59,05,7*EO, ia/ie 15,61,16,61,3*5,81,2*5,11,5*OEAIg, ieiieue/e/oa1,440,051,480,071,450,071,180,08*OAIIg++, ieiieue/e/oa1,440,071,320,101,010,08*0,800,08*Ig a?eo?ioeeo?a, iiieue/e1,520,031,470,03 1,370,03 1,300,02* I?ei?oea. * - iieaciee noaoenoe/ii aeinoia??ii a?ae??ciy?oueny a?ae aiaeia?/iiai o in?a c aenieith aoaeoeai?noth e?eoaaiiy i?aia?aoii, p<0,05. Iae. 1 Noaia o/ano? ii?ooaiue aiiainoaco iaai?th o iaoiaaiac? anaioe?aeueii? a?ia?oaic??. Aeiaeaoeiaee i?eeii iaai?th aeicaieea cieceoe ??aaiue ae?anoie?/iiai AO a a?oi? c iecueeith aoaeoeai?noth e?eoaaiiy aioaaii?noaie eaeueoe?th a na?aaeiueiio ia 5,1±0,9 ii ?o. no, o a?oi? ?c na?aaeiueith aoaeoeai?noth e?eoaaiiy oeeie i?aia?aoaie - ia 6,3±0,9 ii ?o.no. I?ney eo?no e?eoaaiiy aaoa-aae?aiiaeieaoi?aie ??aaiue iaai??i??, OEAMg, OAIMg++, eiioeaio?aoe?y iaai?th a a?eo?ioeeoao, eiioeaio?aoe?y o ieaci? IOA ? EO ia ci?ieeeny. C iaeyaeo ia a?aenooi?noue c?ooaiue o noai? iaoaaie?cio iaai?th a i?ioean? e?eoaaiiy aaoa-aae?aiiaeieaoi?aie, ie i?eeoee aei aeniiaeo i?i a?aenooi?noue caeaaeiino? aoaeoeaiino? e?eoaaiiy aaoa-aae?aiiaeieaoi?aie a?ae noaio iaoaaie?cio iaai?th ? i?i iaaeioe?euei?noue ei?aeoe?? ii?ooaiue eiai iaoaaie?cio a i?ioean? e?eoaaiiy aaoa-aae?aiiaeieaoi?aie. O oai?eo ia AA, ui iaea?aeoaaee o?aceaei? ae?o?aoeee, aacaeueia eiioeaio?aoe?y ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia? cieceeany. Oaeaee?noue eeoeiai? aani?aoe?? iaai?th ca?eueoeeany, OAIMg++ cia/ii ciaioeeany, eiioeaio?aoe?y iaai?th a a?eo?ioeeoao i?aeoe/ii ia ci?ieeany. I?eeii o?aceaeieo ae?o?aoee?a aaaea aei ao?aoe iaai?th ie?eaie, ?? a?aeoeiaeoaaiiy oeyoii aeiaeaoeiaiai i?eeiio iaai?th o aeaeyae? ania?eaia a aeiaia?e aeic? c ?ic?aooieo 0,1 iiieue/ea iaai?th ia aeaiue ia?aoeiaeaeaei a a?oiao oai?eo ia AA ?c na?aaeiueith ? iecueeith aoaeoeai?noth e?eoaaiiy ii?ooaiiy iaoaaie?cio iaai?th. Eiioeaio?aoe?y iaai?th a a?eo?ioeeoao, OEAMg, OAIMg++ c e?ia?, eiioeaio?aoe?y IOA ? EO o ieaci? e?ia? ia ia?aoa?i?ee noaoenoe/ii aeinoia??ieo iaaaoeaieo ci?i. ??aaiue AO a a?oi? c iecueeith aoaeoeai?noth e?eoaaiiy cieceeiny ia 4,5±0,6 ii ?o. no, o a?oi? ?c na?aaeiueith aoaeoeai?noth e?eoaaiiy - ia 5,3±0,7 ii ?o.no. ?acoeueoaoe iaoiai aeine?aeaeaiiy na?ae/aoue i?i oa, ui i?aeo?eiea aiiainoaco iaai?th o oai?eo ia AA a inoaoi/iiio i?aenoieo aeinyaa?oueny oe?iith i?aeaeuaiiy AO. Noaia o/ano? ii?ooaiue aiiainoaco a iaoiaaiac? AA iiaeaia ia iaethieo 1. Ii?ooaiiy iaoaaie?cio iaai?th ? aaaeeeaei oaeoi?ii ?icaeoeo ? i?ia?anoaaiiy AA. Oiio ei?aeoe?y oeeo ii?ooaiue, o oiio /ene? ? a i?ioean? oa?iaeioa?ai??, iaaoaa? i?e AA cia/aiiy iaoiaaiaoe/ii? oa?ai?? ? iiaeiii aooe iaeaaaeeea?oith neeaaeiaith /anoeiith ia?aeiii? ? aoi?eiii? i?io?eaeoeee. AENIIAEE 1. Anaioe?aeuei?e a?ia?oaic?? aeanoea? ?noioi? ii?ooaiiy noaio iaoaaie?cio iaai?th ? ai?iiiaeueii? ?aaoeyoe?? eiai aiiainoaco, ui iathoue iaoiaaiaoe/io ?ieue o iaoai?ciao oi?ioaaiiy ? ?icaeoeo caoai?thaaiiy aiane?aeie oiai, ui i?ecaiaeyoue aei aeinoia??iiai aeao?oeeoo aioo??oiueiee?oeiiiai iaai?th ? ca'ycaiiai c iei i?aeaeuaiiy nenoaiiiai ia?eoa?e/iiai iii?o ? a?oa??aeueiiai oeneo. 2. Oiea?aioi?noue nenoaie iaoaaie?cio iaai?th aei iaaaioaaeaiiy iaai??i, ui aeicaiey? iaea?aeaoe ocaaaeueiaio e?euee?nio oa?aeoa?enoeeo ?? noaio ia ??ai? i?aai?cio, aeeth/ath/e aeoeai?noue ?aaoeyoi?ieo iaoai?ci?a ? ooieoe?th aeeiiaa/eo i?aai?a, i?e anaioe?aeuei?e a?ia?oaic?? cia/ii cieaeaia. 3. Aeiaiaa aene?aoe?y iaai?th, ui a?aeaeaa? eiai ae??oe/ia niiaeeaaiiy, o oai?eo ia anaioe?aeueio a?ia?oaic?th cieaeaia. Iaioa ae??oe/ia niiaeeaaiiy iaai?th niieo/a?oueny c a?eueoith /anoioith a?oa??aeueii? a?ia?oaic??. Eiao?oe??io ei?aeyoe?? i?ae ??aiai a?oa??aeueiiai oeneo ? niiaeeaaiiyi iaai?th neeaa aeey ae?anoie?/iiai - 0,416, aeey nenoie?/iiai - 0,333. 4. Eeoeiaa aani?aoe?y iaai?th, aecia/aia ?ic?iaeaiei iaie iaoiaeii ?c aeei?enoaiiyi ia?i?aeueiiai ? aioo??oiueiaaiiiai iaaaioaaeoaaeueieo oano?a, i?e anaioe?aeuei?e a?ia?oaic?? cieaeaia, ye aiane?aeie cieaeaiiy a?oai?i Ae-caeaaeiiai aeoeaiiai o?ainii?oo, oae ? a?oai?i Ae-iacaeaaeiiai ianeaiiai o?ainii?oo, ? ia eiiiaino? cieaeaia ae??oe/ia niiaeeaaiiy iaai?th. O oai?eo ia anaioe?aeueio a?ia?oaic?th eeoeiaee o?ainii?o a?eueo iacaeaaeiee a?ae a?oai?io Ae3, i?ae o caei?iaeo ethaeae. 5. O oai?eo ia anaioe?aeueio a?ia?oaic?th eiioeaio?aoe?y iaai?th ? ni?aa?aeiioaiiy iaai?e/eaeueoe?e a a?eo?ioeeoao cieaeai? ? iathoue cia/eiee ei?aeyoe?eiee ca'ycie ?c ??aiai a?oa??aeueiiai oeneo (eiao?oe??io ei?aeyoe??, a?aeiia?aeii -0,416 ? -0,530). 6. Iaai?eo?aoe/ia ooieoe?y ie?ie i?e anaioe?aeuei?e a?ia?oaic?? cieaeaia, ui /?oei aeyaey?oueny a oiiaao iaai??aiai iaaaioaaeaiiy. I?e/eiith ineaaeaii? iaai?eo?aoe/ii? ?aaeoe?? o oai?eo ia anaioe?aeueio a?ia?oaic?th ? i?enei?aiiy ianeaiiai eaiaeueoeaaiai o?ainii?oo iaai?th. Aeoeaiee eaiaeueoeaaee o?ainii?o oiia?eueiaiee aiane?aeie cieaeaii? /ooeeaino? ie?eiaeo eaiaeueoe?a aei aieeao ia?aoai?iiia. A oiiaao iaaaioaaeaiue (nieueiaeo, ai?iiiaeueieo ? ae?o?aoe/ieo) ?c iaai?e- ? eaeueoe?eo?aoe/ieie aoaeoaie aene?aoe?y iaai?th c?inoa? a a?eueoiio nooiai?, i?ae aene?aoe?y eaeueoe?th, ui aaaea aei ca?eueoaiiy iaai??aiai aeao?oeeoo a i?aai?ci?. 7. ?ioaineai?noue o?ainii?oo iaai?th i?ae iicaee?oeiiei ? e?noeiaei naeoi?ii o oai?eo ia anaioe?aeueio a?ia?oaic?th ?noioii cieaeaia, ui na?ae/eoue i?i ia?aaaaeaiiy i?e anaioe?aeuei?e a?ia?oaic?? i?ioeano ?aci?aoe?? iaai?th c e?noeiai? oeaieie. Iiaeeiaiiy iaaeeeoeo ?ii?a iaai?th c iicaee?oeiiiai naeoi?a e?noeiaith oeaieiith o oai?eo ia anaioe?aeueio a?ia?oaic?th a?aeaoaa?oueny c iaioith aoaeoeai?noth. I?e/eiith oiia?eueiaiiai aeaaaeaiiy iaai?th c iicaee?oeiii? ??aeeie a e?noeiaee naeoi? ? cieaeaiiy /ooeeaino? inoaieeano?a aei aieeao ia?aoai?iiia. 8. Caaaeueia eiioeaio?aoe?y iaai?th ? eiioeaio?aoe?y eiai ?ii?ciaaii? o?aeoe?? a ne?iaaooe? e?ia? o oai?eo ia anaioe?aeueio a?ia?oaic?th ia a?ae??ciythoueny a?ae iieaciee?a o caei?iaeo in?a. Eeoa o oai?eo ?c aenieei noaa?eueiei ??aiai ae?anoie?/iiai a?oa??aeueiiai oeneo, ui ia?aaeuo? 115 ii ?o. no., eiioeaio?aoe?y ?ii?ciaaiiai iaai?th ia? oaiaeaioe?th aei cieaeaiiy. Noae?noue iaai??i?? a oiiaao cieaeaiiai iaaeoiaeaeaiiy iaai?th a iicaee?oeiiee naeoi? ?c eeoie aeinyaa?oueny i?aeaeuaiiyi aeoeaiino? ?aaoeyoi?ieo iaoai?ci?a ? ii?ooaiiyi ai?noo iaai?th a ?ioeo naeoi?ao i?aai?cio ? o?ainii?oo i?ae ieie. 9. Ai?iiiaeueia ?aaoeyoe?y iaoaaie?cio iaai?th i?e anaioe?aeuei?e a?ia?oaic?? ii?ooaia. Eiioeaio?aoe?y ia?aoai?iiia ? eaeueoeeoii?ia o ieaci? e?ia? oai?eo ia anaioe?aeueio a?ia?oaic?th i?aeaeuaia, a eiioeaio?aoe?y 1,25(II)2Ae3 cieaeaia. *ooeea?noue aei ci?i iaai??i?? ee?oei, ui nae?aoothoue ia?aoai?iii ? eaeueoeeoii?i, o oai?eo ia anaioe?aeueio a?ia?oaic?th i?aeaeuaia, a /ooeea?noue aeeiiaa/eo i?aai?a iaoaaie?cio iaai?th aei aieeao ?aaoethth/eo ai?iii?a cieaeaia. 10. Ca?eueoaiiy aeiaiaiai niiaeeaaiiy iaai?th oeyoii uiaeaiiiai i?eeiio ania?eaia i?ioyaii 3 i?nyoe?a o aeiaia?e aeic? 0,1 iiieue/ea iane o?ea ia noi?iaiaeaeoaaeiny noaoenoe/ii aeinoia??iith ci?iith ??aiy nenoie?/iiai ? ae?anoie?/iiai a?oa??aeueiiai oeneo a in?a c anaioe?aeueiith a?ia?oaic??th, iaeiae ni?eyei cieaeaiith ?aaeoeaiino? na?oeaai-noaeeiii? nenoaie a oiiaao aieeao aacii?ani?ieo oaeoi??a ? i?aeaeuaiith oiea?aioiino? aei o?ce/iiai iaaaioaaeaiiy, ? oiio iiaea aooe neeaaeiaith /anoeiith aioea?ia?oaiceaii? oa?ai??. 11. Aoaeoeai?noue e?eoaaiiy anaioe?aeueii? a?ia?oaic?? ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo, aioaaii?noaie eaeueoe?th ? ae?o?aoeeaie caeaaeeoue a?ae noaio iaoaaie?cio iaai?th. E?eoaaiiy ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo aoaeoeaii o oai?eo ia anaioe?aeueio a?ia?oaic?th ?c ii?iaeueiei noaiii iaoaaie?cio iaai?th. Aoaeoeai?noue aioaaii?no?a eaeueoe?th aeua o oai?eo ?c ii?ooaiiyie iaoaaie?cio iaai?th. Nooi?iue aoaeoeaiino? e?eoaaiiy aaoa-aae?aiiaeieaoi?aie ia caeaaeeoue a?ae noaio iaoaaie?cio iaai?th. Iiiioa?ai?y o?aceaeiei ae?o?aoeeii iaaoaeoeaia i?e aioo??oiuei- ? iicaee?oeiiiio aeao?oeeo? iaai?th a i?aai?ci?. 12. O?eaaeee i?eeii ?ia?a?oi??a aia?ioaicei-ia?aoai?thth/iai oa?iaioo ? aaoa-aae?aiiaeieaoi??a ia aeeeeea? aeinoia??ieo ci?i o noai? iaoaaie?cio iaai?th. O?eaaeee i?eeii aioaaii?no?a eaeueoe?th ? o?aceaeieo ae?o?aoee?a aeeeeea? ii?ooaiiy iaoaaie?cio iaai?th, ui aeyaeythoueny ca?eueoaiiyi eiai iica- ? aioo??oiueiee?oeiiiai aeao?oeeoo. Aeinoaoi? caaacia/aiiy i?aai?cio iaai??i oeyoii aeiaeaoeiaiai i?eeiio 0,1 iiieue/ea iaai?th a aeaiue aeicaiey? i?aeaeueoe aoaeoeai?noue e?eoaaiiy oai?eo ia anaioe?aeueio a?ia?oaic?th ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo, aioaaii?noaie eaeueoe?th ? o?aceaeieie ae?o?aoeeaie. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey aaeaeaaoii? oa?aeoa?enoeee noaio aiiainoaco iaai?th o oai?eo ia anaioe?aeueio a?ia?oaic?th a ee?i?/ieo oiiaao aa?oi aeei?enoiaoaaoe iaai?eoiea?aioiee oano - aioo??oiueiaaiiee aai ia?i?aeueiee. Iaai?eoiea?aioiee oano ia? ia?aaaae ia?aae ?ioeie iaoiaeaie ioe?iee noaio iaoaaie?cio iaai?th, ine?eueee aeicaiey? iaea?aeaoe eiai ocaaaeueiaio e?euee?nio oa?aeoa?enoeeo ia ??ai? i?aai?cio, aeniei aeioeoeueiee ? aeyaey? ii??aiyii iaaaeee? c?ooaiiy aiiainoaco. Aioo??oiueiaaiiee iaai?eoiea?aioiee oano i?iaiaeeoueny oeyoii aioo??oiueiaaiiiai aaaaeaiiy 0,1 iiieue iaai?th noeueoaoo ia 1 ea iane o?ea. Aeine?aeaeothoue ??aaiue iaai?ai?? /a?ac 20 ? 150 oaeeei i?ney eiai aaaaeaiiy. *a?ac 150 oaeeei i?ney aioo??oiueiaaiiiai aaaaeaiiy iaaaioaaeaiiy a ii?i? aiii oe?eeii e?ea?aeo?oueny c e?ia?. I?e i?iaaaeaii? ia?i?aeueiiai iaai?eoiea?aioiiai oanoo i?ney acyooy e?ia? c e?eoueiai? aaie, iniaa, ui ianoaaeo?oueny, i?eeia? ia?i?aeueii n?eue iaai?th c ?ic?aooieo 0,1 iiieue iaai?th ia ea iane o?ea, caieaath/e ?? 100 ie aeenoeeueiaaii? aiaee. *a?ac 240 oaeeei iaaaioaaeaiiy a ii?i? oe?eeii e?ea?aeo?oueny c e?ia?. 2. C iaoith i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia anaioe?aeueio a?ia?oaic?th i?e aeiai?? aioea?ia?oaiceaiiai i?aia?aoo, e??i a?aeiieo iieacaiue, aa?oi a?aoiaoaaoe noai iaoaaie?cio iaai?th. I?ecia/aiiy ?ia?a?oi?o aia?ioaicei-ia?aoai?thth/iai oa?iaioo aeioe?eueii i?e ii?iaeuei?e aacaeuei?e eiioeaio?aoe?? ?ii?ciaaiiai iaai?th a ne?iaaooe? e?ia? (ia iaio 0,52 iiieue/e) ? a a?eo?ioeeoao (ia iaio 1,4 iiieue/e), i?e aenie?e oaeaeeino? ae?i?iaoe?? iaaaioaaeoaaeueii? iaai??i?? (ia iaio 1,40 ieiieue/e/oa), i?e ii?iaeuei?e eiioeaio?aoe?? ia?aoai?iiia (ia a?eueo 96 ia/ie) ? eaeueoeeoii?ia (ia a?eueo 13 ia/ie) o ieaci? e?ia?. I?ecia/aiiy aioaaii?no?a eaeueoe?th iaea?eueo aei?aaaeaii oai?ei anaioe?aeueiith a?ia?oaic??th, o yeeo eiioeaio?aoe?y ?ii?ciaaiiai iaai?th ia a?aeiiaeth?oueny i?ney ia?i?aeueiiai iaaaioaaeaiiy iaai??i o i?ioean? iaai?eoiea?aioiiai oanoo, i?aeaeuaia eiioeaio?aoe?y ia?aoai?iiia a ieaci? e?ia? ? cieaeaia eiioeaio?aoe?y aioo??oiueia?eo?ioeeoa?iiai iaai?th. I?ecia/aiith aaoa-aae?aiiaeieaoi??a oai?ei anaioe?aeueiith a?ia?oaic??th aa?oi a?aeaeaaaoe ia?aaaao i?e a?aeiia?aeieo aaiiaeeiai?/ieo oa?aeoa?enoeeao, cie?aia i?e iayaiino? oaiaeaioe?? aei oao?ea?ae??, ia ea?oth/enue i?e oeueiio iieacieeaie noaia iaoaaie?cio iaai?th. O?aceaei? ae?o?aoeee aa?oi i?ecia/aoe oai?ei anaioe?aeueiith a?ia?oaic??th, ui ia iathoue a?aeoeeaiue iieaciee?a iaoaaie?cio iaai?th. 3. Aeey i?aeaeuaiiy oiea?aioiino? aei o?ce/iiai iaaaioaaeaiiy oai?ei anaioe?aeueiith a?ia?oaic??th aa?oi ca?eueoeoe aeiaiaa niiaeeaaiiy iaai?th oeyoii i?ecia/aiiy uiaeaiiiai i?eeiio ania?eaia i?ioyaii ia iaioa 3 i?nyoe?a o aeiaia?e aeic? 0,15 iiieue/ea iane o?ea. 4. Aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia anaioe?aeueio a?ia?oaic?th ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo, aioaaii?noaie eaeueoe?th ? o?aceaeieie ae?o?aoeeaie eiai aa?oi niieo/aoe c aeiaeaoeiaei i?eeiiii 0,1 iiieue/ea iaai?th ia aeiao. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. Aia?iaa I.A. Aieea eaeueoei?aeo iaaaioaaeaiue ia noai aiiainoaco eaeueoeith oa ?iaaiue a?oa?iaeueiiai oeneo i?e anaioeiaeueiie aiia?oaici? // Anaioeiaeueia aiia?oaiciy i aiiainoac eaeueoeith.-E.: *aoaa?oa oaeey, 1998.- N.119-126. 2. Aia?iaa I.A. Ia?aeiia i?ioieaeoeea a?oa?iaeueii? aiia?oaici? oeyoii iaiaaeeeaiaioicii? ei?aeoei? ii?ooaiue aiiainoaco eaeueoeith // Anaioeiaeueia aiia?oaiciy i aiiainoac eaeueoeith.- E.: *aoaa?oa oaeey, 1998.- N.127-145. 3. Aia?iaa I.A. Iaoioiciieiai/ia cia/aiiy ii?ooaiue aiiainoaco eaeueoeith o ?icaeoeo oa eeiii/iiio ia?aaiao anaioeiaeueii? aiia?oaici? // Anaioeiaeueia aiia?oaiciy i aiiainoac eaeueoeith.- E.: *aoaa?oa oaeey, 1998.- N.146-164. 4. Aia?iaa I.A. Niiaaiaeiioaiiy ie?eiaiai o?ainii?oo eaeueoeith i iaaiith i?e anaioeiaeueiie aiia?oaici? // Anaioeiaeueia aiia?oaiciy i aiiainoac eaeueoeith. - E.: *aoaa?oa oaeey, 1998.- N.165-176. 5. Aia?iaa A.A. Iaoaaieeci iaaiey o aieueiuo n ynnaioeeaeueiie aeia?oaiceae // Oe?. ea?aeiie. aeo?i.- 1997.- N 1 (aei.2).- N.33-36. 6. Aia?iaa A.A. Ii/a/iue o?ainii?o a nenoaia ?aaoeyoeee aiiainoaca iaaiey i?e ynnaioeeaeueiie aeia?oaicee // Oe?. ea?aeiie. aeo?i.- 1997.- N 3 (aei. 2).- N.40-43. 7. 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Yieaeaieieiaey a?oa?eaeueiie aeia?oaicee e aa aaaeiaeoeo oaeoi?ia ?enea a iiioeyoeee i?iiuoeaiiuo ?aai/eo Aeiiaanna // A?oea eeeie/aneie e yenia?eiaioaeueiie iaaeeoeeiu.- 1996.- O.5, N 2.- N.163-166. 13. Eieiieaoe A.A., Aia?iaa A.A., Naaa I., Eieanieeiaa O.N. Ei??aeoeey aeeaoe/aneiai iio?aaeaiey eaeey e iaaiey a iiioeyoeeiiiie i?ioeeaeoeea a?oa?eaeueiie aeia?oaicee // Oe?. ea?aeiie. aeo?i.- 1997.- N 3.- N.36-39. 14. Eieanieeiaa O.N., Eieiieaoe A.A., Aia?iaa A.A. Aeeyiea ino?ie aeia?eaeueoeeaiee ia oeaio?aeueioth aaiiaeeiaieeo e ia?eoa?e/aneee e?iaioie i?e ynnaioeeaeueiie aeia?oaicee // Oe?. ea?aeiie. aeo?i. - 1997.- N 5-6.- N.40-43. 15. Eieiieaoe A.A., Aia?iaa A.A. Oeceieiae/aneea iaoaieciu ?aaoeyoeee iaoaaieecia iaaiey. // Oe?. ea?aeiie. aeo?i.- 1998.- N 4.- N.54-58. 16. Eieiieaoe A.A., Aaioaiai I.A., Aaeea? A.O., ?oaeaiei I.I., Aeiineiaa O.A., Ianei?iaeue O.E., Aia?iaa A.A., Eieanieeiaa O.N., Aiiaea?aiei A.A., Ci?eia I.A. Aioeaeia?oaiceaiue, aaiiaeeiaie/aneee e iaoaaiee/aneee yooaeo eiaeaeoi?a aiaeioaicei-i?aa?auathuaai oa?iaioa yiaeai?eea // Oe?. ea?aeiie. aeo?i.- 1998.- N 6.- N.44-47. 17. Eieiieaoe A.A., Aia?iaa A.A., Eieanieeiaa O.N. Ai?iiiaeueiay e oa?iaeieiae/aneay ?aaoeyoeey ii/a/iiai o?ainii?oa eaeueoeey e iaaiey i?e ynnaioeeaeueiie aeia?oaicee // Oe?. ea?aeiie. aeo?i. - 1999.- N 2.- C.28-32. 18. Aia?iaa A.A. Iaoaio ? 2079129 ia ecia?aoaiea: “Niinia aeeaaiinoeee eaoaioiie oi?iu o?iie/aneiai ieaeiiao?eoa o aieueiuo n aeia?oaiceaiui neiae?iiii aac niioonoaothueo o?ieiae/aneeo caaieaaaiee” (iaoaioiiaeaaeaoaeue Oe?IEE ea?aeeieiaee ei. aeaae.I.Ae.No?aaeanea) a niaaoi?noaa, auaeai Eiieoaoii ?inneeneie Oaaea?aoeee ii iaoaioai e oiaa?iui ciaeai (?iniaoaio) 10.05.97. 19. Aia?iaa A.A. Eiee/anoaaiiay ioeaiea eeoa/iie aani?aoeee iaaiey i?e ynnaioeeaeueiie aeia?oaicee // Aeooaeuei? ieoaiiy iaaeaaia?ee, aenia?eiaioaeueii? oa ee?i?/ii? iaaeeoeeie.-Aeiiaoeuee, 1995.-O.1.-N.37-39. 20. Eieiieaoe A.A., Iiaeieyea A.E., Eieanieeiaa O.N., Aia?iaa A.A., Aaioaiai I.A. Caaeneiinoue aioeaeia?oaiceaiie yooaeoeaiinoe aioaaiienoia eaeueoeey io ninoiyiey aiiainoaca eaeueoeey, iaaiey e aeoeaiinoe ?aieia ieaciu: iiaue iiaeoiae e eiaeeaeaeoaeecaoeee ea/aiey // Aeooaeueii ieoaiiy iaaeaaiaiee, aenia?eiaioaeueii? oa eeiii/ii? iaaeeoeeie.- Aeiiaoee, 1995.- O.2.- N.112-115. 21. Aia?ia A.I., Eieiii?oeue A.A., Aia?iaa I.A. Iaaaoeaiee aieea aioaaiiinoia eaeueoeith ia eeoeiao aani?aoeith eaeueoeith oa iaaiith i?e anaioeiaeueiie aiia?oiii? // Nioeeaeueii-iaaeeoeeineea aniaeou io?aiu caei?iauey.- Aeiai?iiao?iane, 1995.- N.32-34. 22. Aia?iaa A.A. Ii/ee e nenoaia ?aaoeyoeee aiiainoaca iaaiey o aieueiuo ynnaioeeaeueiie aeia?oaiceae // Nioeeaeueii-iaaeeoeeineea aniaeou io?aiu caei?iauey.- Aeiai?iiao?iane, 1995.- N.35-37. 23. Aia?iaa A.A. 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Kolomiets V., Kolesnikova T., Bobrova E., Vanchanen N., Bekker V., Parkhomenko T. Calcium and magnesium homeostasis alterations correction decrease the vascular reactivity in hypertensive patients // Proc. Alpha-Adria Cardiology Meeting 5-th in Austria at the University of Graz / Vorklinische Institute Harrachgasse 21.-Graz (Austria).-1997.-P.59. 43. Aia?iaa A.A., Naaa I., Eieiieaoe A.A. Ei??aeoeey ia?ooaiee iaiaia iaaiey a ea/aiee e i?ioeeaeoeea ynnaioeeaeueiie aeia?oaicee // Eiia?ann annioeeaoeee ea?aeeieiaia no?ai NIA 1-e.-Iineaa (?inney): Iaaeea Noa?a.-1997.-N.122. 44. Eieiieaoe A.A., Eieanieeiaa O.N., Aia?iaa A.A., Aeiineiaa O.A. Aiciiaeiinoue iiauoaiey aioeaeia?oaiceaiie yooaeoeaiinoe aioaaiienoia eaeueoeey o aieueiuo n ?acee/iie aeoeaiinoueth ?aieia ieaciu // Eiia?ann annioeeaoeee ea?aeeieiaia no?ai NIA 1-e.-Iineaa (?inney): Iaaeea Noa?a.-1997.-N.206. 45. ss?uieeia A.A., Aia?iaa A.A., Naeuaiei A.I., Eiaeaeoi? AIO yiaeai?ee nieaeaao eiioeaio?aoeeth eiiece?iaaiiiai aioo?eeeaoi/iiai eaeueoeey o aieueiuo n ynnaioeeaeueiie aeia?oaiceae // Eiia?ann annioeeaoeee ea?aeeieiaia no?ai NIA 1-e.-Iineaa (?inney): Iaaeea Noa?a.-1997.-N.227. 46. Kolomiets V., Kolesnikova T., Bobrova E. The decrease of vascular reactivity arter calcium and magnesium homeostasis disturbances correction during pharmacotherapy of hypertension // Proc. International Symp. on Cardiovas. Pharmacotherapy 7-th.-Jerusalem (Israel).-1997.-P.329. 47. Bobrova E., Kolesnilova T.S. Calcium and magnesium potentiate an antihypertensive activity of angiotensin converting enzyme inhibitors // Proc. International Symp. on Cardiovas. Pharmacotherapy 7-th.-Jerusalem (Israel).-1997.-P.345. 48. Bobrov V., Kolomiets V., Bobrova E., Kolesnikova T., Bondarenko G. Calcium entry blockers antihypertensive action dependent on homeostasis condition // Proc. Nordic Congress of Cardiology XVI.-Tampere (Finland).-1997.-S.29 (P.34). 49. Bobrova E. Magnesium intestinal absorption in pathogenesis of hypertension // Proc. European Meeting on Hypertension 8-th.-Milan (Italy).-1997.-S.128 (P.34). 50. Iarynkina E.A., Svishenko E.P., Mhytorian L.S., Bobrova E.V., Mishchenko L.A. Bezrodnaya L.V. Angiotensin converting enzyme inhibitor (enalapril) and calcium channel blocker (nifedipine) drop blood pressure by cytosolic free calcium concentration decrease // Proc. European Meeting on Hypertension 8-th.-Milan (Italy).-1997.-S.151 (P.135). 51. Kolomiets V.V., Bobrova E. Magnesium homeostasis as a pathogenetic target in hypertension // Proc. European Meeting on Hypertension 8-th.-Milan (Italy).-1997.-S.157 (P.166). 52. Parkhomenko T., Bobrova E., Kolomiets V.V., Saeg M. Dietary calcium, magnesium, phosphorus ratio intake correction is a basis for hypertension prevention // Proc. European Meeting on Hypertension 8-th.-Milan (Italy).-1997.-S.177 (P.259). 53. Bobrova E., Saeg M., Kolomiets V.V. Correction of magnesium disturbances in treatment and prophylaxis of essential hypertension // Proc. International Conference on Preventive Cardiology 4-th Jointly with the 37-th Annual Meeting of the Council on Epidemiology and Prevention, American Heart Association.-Montreal (Canada).-1997.-B.201-202 (N 0709). 54. Bobrova E., Kolomiets V. Magnesiumuretic renal function and essential hypertension // Proc. International Congress of the Polish Cardiovasc. Society 1-st.-Warszawa (Poland).-1997.-N.98 55. Aia?iaa A.A., Eieiieaoe A.A., Eieanieeiaa O.N. Ai?iiiaeueiay ?aaoeyoeey eioanoeiaeueiie aani?aoeee iaaiey a iaoiaaiaca aeia?oaicee //Eiia?ann annioeeaoeee ea?aeeieiaia no?ai N?aaeiae Acee 3-e.-Oaoeaio (Ocaaeenoai).-1997.-N.29. 56. Eieiieaoe A.A., Eieanieeiaa O.N., Aia?iaa A.A. Ei??aeoeey ia?ooaiee aiiainoaca eaeueoeey e iaaiey ai a?aiy oa?iaeioa?aiee i?e aeia?oaicee // Eiia?ann annioeeaoeee ea?aeeieiaia no?ai N?aaeiae Acee 3-e.-Oaoeaio (Ocaaeenoai).-1997.-N.53. 57. Bobrova E., Kolomiets V.V. Negative influence of drugs upon blood mineral imbalance in hypertension // Proc. European Federation of the International Medicine.-1-st.-Maastricht (Netherlands).-1997.-/Europ. J. Intern. Med.-1997.-Vol.8 (Supl.1).-S.113 (P.267). 58. Bobrov V., Kolomiets V., Bobrova E. Essential hypertension and alimentary potassium consumption // Proc. World Congress of Cardiology 13-th.-Rio de Janiero (Brasil).-1998.-C.5.-N 56. 59. Kolomiets V.V., Bobrova E.., Kolesnikova T.S. Correction of calcium and magnesium homeostasis disturbances during pharmacotherapy of hypertensive patients // Proc. Scientific Meeting of the American Society of Hypertension 13-th.-1998.-New York (USA) /Amer. J. Hypertension.-Vol.11, N 4 (Pt. 2).-102A (poster E028). 60. Bezrodnaya L., Svyshchenko E., Kupchiskaya E., Bobrova E., Yarinkina E. Differences in ionized calcium distribution between plasma and cell depending on hypertension grade // Proc. Scientific Meeting of the American Society of Hypertension 13-th.-1998.-New York (USA) /Amer. J. Hypertension.-Vol.11, N 4 (Pt. 2).-155A (poster F007). 61. Bobrova E., Kolomiets V.V. Kolesnikova T.S. Hormonal and diuretic regulation of magnesium renal transport in hypertension // Proc. Scientific Meeting of the American Society of Hypertension 17-th.-1998.-Amsterdam (Netherlands).- /Journal of Hypertension.Official Journal of the International Society of Hypertension and the European Society of Hypertension.-S.305. 62. Bobrova E., Kolomiets V.V. Kolesnikova T.S. Calcium, magnesium homeostasis and renin-angiotensin system in hypertension pathophysiology //Proc. Scientific Meeting of the American Society of Hypertension 17-th.-1998.-Amsterdam (Netherlands).- /Journal of Hypertension.Official Journal of the International Society of Hypertension and the European Society of Hypertension.-S.306. 63. Kolomiets V.V., Kolesnikova T.S., Bobrova E. 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Ie?eiaee o?ainii?o iaaiith o oai?eo ia a?oa?iaeueio aiia?oaicith iioeeiai aieo // I?aoei iaoe.-i?aeo. eiio. “A?oa?iaeueia aiia?oaiciy i aie”.- E., 1998.- N.10-11. 68. Bobrova A.V., Kolomiets V.V., Kolesnikova T.S. Calcium and magnesium homeostasis disturbances correction during pharmacotherapy in hypertension // 1-st International Congress on Heart Disease – New Trends, Diagnosis and Treatment. – 1999. – Washington, USA. – (abst. N 1023). 69. Bobrova E.V., Kolomiets V.V. Hormonal regulation of magnesium intestinal absorption in pathogenesis of hypertension // Journal of Hypertension 17 (Suppl. 3), May 1999, page S214. 70. Kolomiets V.V., Bobrova E.V. The integrated view of magnesium homeostasis pathophysiology in hypertension // Journal of Hypertension 17 (Suppl. 3), May 1999, page S247. AIIOAOe?ss Aia?iaa I.A. Aiiainoac iaai?th i?e anaioe?aeuei?e a?ia?oaic?? (ee?i?ei-o?c?ieia?/ia oa?aeoa?enoeea, iaoio?c?ieia?y, ai?iiiaeueia ?aaoeyoe?y, ei?aeoe?y ii?ooaiue, iaa?oiooaaiiy aeai?o aioea?ia?oaiceaii? oa?ai??).- ?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy aeieoi?a iaaee/ieo iaoe ca oaoii 14.01.11 - ea?ae?ieia?y.-?inoeooo ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie, Ee?a, 1999. I?iaaaeaii eiiieaenia aeine?aeaeaiiy iaoio?c?ieia?? iaoaaie?cio iaai?th i?e AA, aeey yei? ? oa?aeoa?ia cieaeaiiy ae??oe/iiai niiaeeaaiiy, eeoeiai? aani?aoe?? iaai?th, iaai?eo?aoe/ii? ooieoe?? ie?ie ? aioo??oiueia?eo?ioeeoa?ii? eiioeaio?aoe??, ii?ooaiiy e?noeiaiai o?ainii?oo iaai?th c ia?aaaaeaiiyi ?aci?aoe??, cieaeaiiy oiea?aioiino? aei iaai??aeo iaaaioaaeaiue, ii?ooaiiy ai?iiiaeueii? ?aaoeyoe?? c i?aeaeuaiiyi i?iaeoeoe?? ia?aoai?iiia, eaeueoeeoii?ia ? cieaeaiiyi ooai?aiiy 1,25-ae?a?ae?ien?oieaeaeueoeeoa?iea, cieaeaiiy /ooeeaino? i?aai?a-i?oaiae aei aieeao ai?iii?a. Cai?iiiiiaaii iaoiae aaeaeaaoii? ioe?iee noaio iaoaaie?cio iaai?th, i?eaeaoiee aeey aeei?enoaiiy a ee?i?oe?. Anoaiiaeaii iaoiaaiaoe/ia cia/aiiy ii?ooaiue iaoaaie?cio iaai?y a iaoiaaiac? AA. Aeiaaaeaii aeioe?euei?noue aeine?aeaeaiiy iaoaaie?cio iaai?y aeey iioei?caoe?? aeai?o iaea?eueo aoaeoeaieo i?aia?ao?a aeey e?eoaaiiy AA. Cai?iiiiiaaii, iaa?oioiaaii oai?aoe/ii oa ai?iaiaaii iaoiae cieaeaiiy ?aaeoeaiino? na?oeaai-noaeeiii? nenoaie aei aacii?ani?ieo aieea?a ? i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo AA aioea?ia?oaiceaieie oa?iaeii?aia?aoaie, caniiaaiee ia ei?aeoe?? ii?ooaiue iaoaaie?cio iaai?th oeyoii eiai aeiaeaoeiaiai i?eeiio. O ?iaio? ?icaeaa?oueny iiaee iai?yiie o i?io?eaeoeoe? AA, caniiaaiee ia eiioeaioe?? iaoiaaiaoe/iie ?ie? ii?ooaiue iaoaaie?cio iaai?th a ?icaeoeo AA. Eeth/ia? neiaa: anaioe?aeueia a?ia?oaic?y, iaoaaie?ci iaai?th, iaoiaaiac, ei?aeoe?y ii?ooaiue, i?io?eaeoeea. SUMMARY Bobrova E.V. Magnesium homeostasis in essential hypertension (clinical and physiological characteristic, pathophysiology, hormonal regulation, correction of impairments, substantiation of a choice of antihypertensive therapy).- The manuscript. Dissertation on competition of a scientific degree of the doctor of medical sciences on a speciality 14.01.11 - cardiology.-Strazhesko Institute of cardiology, AIS of Ukraine, Kiev, 1999. The complex research of magnesium metaboloism pathophysiology is carried out in essential hypertension (EH), in which are characteristic decrease of dietary consumption, enteric magnesium absorption, magnesium excretory function of kidneys and intracellular concentration in red blood cell, impairment of bone magnesium transport with prevalence resorption, reduction of tolerance to magnesium load, impairment hormonal regulation with increase of production of parathormone and calcitonine and decrease of formation 1,25-dihydroxycholecalciferole, decrease of sensitivity of targets bodies to hormonal influences. The method of an adequate estimation of a magnesium metabolism, suitable for use in clinic is offered. It was established pathogenetic importance of magnesium metabolism impairment in pathogenesis of EH. The expediency of research magnesium metabolism for optimisation of a choice of the most effective preparations for treatment EH is proved. It is offered theoretically reasonable and explored a method of reduction of reactiveness of heart-circulatory system to influences of pressors and increase of efficiency of treatment of the patients with EH, based on correction of magnesium metabolism impairment by its additional comsumption. In work is developed the new direction in preventive management of EH, based on the concept of pathogenetic role of magnesium metabolism impairment in development of EH. Key words: essential hypertension, magnasium metabolism, pathogenesis, correction of impairment, preventive management. AIIIOAOeEss Aia?iaa A.A. Aiiainoac iaaiey i?e ynnaioeeaeueiie aeia?oaicee (eeeieei-oeceieiae/aneay oa?aeoa?enoeea, iaoioeceieiaey, ai?iiiaeueiay ?aaoeyoeey, ei??aeoeey ia?ooaiee, iainiiaaiea auai?a aioeaeia?oaiceaiie oa?aiee).- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey.-Einoeooo ea?aeeieiaee ei. aeaae. I.Ae.No?aaeanei AII Oe?aeiu, Eeaa, 1999. I?iaaaeaii eiiieaeniia enneaaeiaaiea iaoioeceieiaee iaoaaieecia iaaiey i?e ynnaioeeaeueiie aeia?oaicee (YA), aeey eioi?ie oa?aeoa?iu nieaeaiea aeeaoe/aneiai iio?aaeaiey, eeoa/iie aani?aoeee iaaiey, iaaieeo?aoe/aneie ooieoeee ii/ae e aioo?ey?eo?ioeeoa?iie eiioeaio?aoeee, ia?ooaiea einoiiai o?ainii?oa iaaiey n i?aiaeaaeaieai ?aci?aoeee, nieaeaiea oiea?aioiinoe e iaaieaaui iaa?oceai, ia?ooaiea ai?iiiaeueiie ?aaoeyoeee n iiauoaieai i?iaeoeoeee ia?aoai?iiia, eaeueoeeoiieia e nieaeaieai ia?aciaaiey 1,25-aeeaeae?ieneoieaeaeueoeeoa-?iea, nieaeaiea /oanoaeoaeueiinoe i?aaiia-ieoaiae e aicaeaenoaeth ai?iiiia. A oneiaeyo iaa?ocie (nieaauo, ai?iiiaeueiuo e aeeo?aoe/aneeo) n eaeueoeee- e iaaieeo?aoe/aneei yooaeoii yene?aoeey iaaiey aic?anoaao a aieueoae noaiaie, /ai yene?aoeey eaeueoeey, /oi aaaeao e onoaoaeaieth iaaieaaiai aeaoeoeeoa a i?aaiecia e yaeyaony iaeiei ec iaoiaaiaoe/aneeo iaoaieciia ?acaeoey YA. I?aaeeiaeai iaoiae aaeaeaaoiie ioeaiee ninoiyiey iaoaaieecia iaaiey n iiiiuueth iaaieeoiea?aioiuo oanoia, iicaieythueo iieo/eoue aai iaiauaiioth oa?aeoa?enoeeo ia o?iaia i?aaiecia e i?eaiaeiue aeey eniieueciaaiey a eeeieea. Onoaiiaeaii iaoiaaiaoe/aneia cia/aiea ia?ooaiee iaoaaieecia iaaiey a iaoiaaiaca YA. Aeieacaia oeaeaniia?aciinoue enneaaeiaaiey iaoaaieecia iaaiey aeey iioeiecaoeee auai?a iaeaieaa yooaeoeaiuo i?aia?aoia aeey ea/aiey YA. Auyaeaii, /oi yooaeoeaiinoue ea/aiey YA eiaeaeoi?aie AIO, aioaaiienoaie eaeueoeey e aeeo?aoeeaie caaeneo io ninoiyiey iaoaaieecia iaaiey.Ea/aiea eiaeaeoi?aie AIO yooaeoeaii o aieueiuo YA n ii?iaeueiui ninoiyieai iaoaaieecia iaaiey. Yooaeoeaiinoue aioaaiienoia eaeueoeey auoa o aieueiuo n ia?ooaieyie iaoaaieecia iaaiey. Noaiaiue yooaeoeaiinoe ea/aiey aaoa-aae?aiiaeieaoi?aie ia caaeneo io ninoiyiey iaoaaieecia iaaiey. Iiiioa?aiey oeaceaeiui aeeo?aoeeii iayooaeoeaia i?e aioo?e- e aiaeeaoi/iii aeaoeoeeoa iaaiey a i?aaiecia. Aeeeoaeueiue i?eai eiaeaeoi?ia AIO e aaoa-aae?aiiaei-eaoi?ia ia aucuaaao eciaiaiee a ninoiyiee iaoaaieecia iaaiey.Aeeeoaeueiue i?eai aioaaiienoia eaeueoeey e oeaceaeiuo aeeo?aoeeia aucuaaao ia?ooaiea iaoaaieecia iaaiey, i?iyaeythuaany oaaee/aieai aai aia- e aioo?eeeaoi/iiai aeaoeoeeoa. Aeinoaoi/iia iaania/aiea i?aaiecia iaaieai iooai aeiiieieoaeueiiai i?eaia 0,1 iiieue/ea iaaiey a aeaiue iicaieyao iiauneoue yooaeoeaiinoue ea/aiey aieueiuo YA eiaeaeoi?aie AIO, aioaaiienoaie eaeueoeey e oeaceaeiuie aeeo?aoeeaie. I?aaeeiaeai, iainiiaai oai?aoe/anee e ai?iae?iaai iaoiae nieaeaiey ?aaeoeaiinoe na?aea/ii-ninoaeenoie nenoaiu e aacii?anni?iui aicaeaenoaeyi e iiauoaiey yooaeoeaiinoe ea/aiey aieueiuo YA aioeaeia?oaiceaiuie oa?iaeii?aia?aoaie, iniiaaiiue ia ei??aeoeee ia?ooaiee iaoaaieecia iaaiey iooai aai aeiiieieoaeueiiai i?eaia. A ?aaioa ?acaeaaaony iiaia iai?aaeaiea a i?ioeeaeoeea YA, iniiaaiiia ia eiioeaioeee iaoiaaiaoe/aneie ?iee ia?ooaiee iaoaaieecia iaaiey a ?acaeoee YA. Eeth/aaua neiaa: ynnaioeeaeueiay aeia?oaicey, iaoaaieeci iaaiey, iaoiaaiac, ei??aeoeey ia?ooaiee, ia?ae/iay e aoi?e/iay i?ioeeaeoeea.

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