.

Глюкамін у комплексній терапії хворих на псоріаз: Автореф. дис… канд. мед. наук / О.А. Броше, Нац. мед. ун-т ім. О.О.Богомольця. — К., 1998. — 15 с.

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IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO ?I. I.I.AIAIIIEUeOess

A ? I O A I E A I A A I A O I E ? ? A I A

OAeE: 616.517-085.37

AETHEAI?I O EIIIEAENI?E OA?AI?? OAI?EO IA INI??AC

– oe??i? oa aaia?e/i? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

i. Ee?a – 1998 ?.

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe, i?ioani? Aeauoe Aiae??e
Ieoaeeiae/, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee
eaoaae?ith oe??ieo oa aaia?e/ieo oai?ia.

Iaoeiaee eiinoeueoaio – caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,
aeieoi? iaaee/ieo iaoe, i?ioani? sseiaoeiaa Aioii?ia Oaaei??aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee eaoaae?ith
iaoieia?/ii? aiaoii??.

Io?oe?ei? iiiiaioe: – aeieoi? iaaee/ieo iaoe, i?ioani? Eyoaiei ?aai
Ieeeoi?iae/, A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
I.?.Ie?iaiaa, i?ioani? eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.

– eaiaeeaeao iaaee/ieo iaoe, aeioeaio
Ooiaiueei Ieeiea Ieoaeeiae/, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.
I.I.Aiaiiieueoey, aeioeaio eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i. I.E.Ooieea.

Caoeno a?aeaoaeaoueny “21” n?/iy 1999 ?. i 13-30 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.02 i?e Iaoe?iiaeueiiio
iaaee/iiio oi?aa?neoao? ?i. I.I.Aiaiiieueoey ca aae?anith: 252004, i.
Ee?a, a. Oaa/aiei, 13.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey ca aae?anith: 252004, i.
Ee?a, a. Oaa/aiei, 13.

Aaoi?aoa?ao ?ic?neaiee “ 11 ” a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Ae.i.i., aeioeaio NAE?EAe N.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie.

Ini??ac ? iaeiei c iae?iciianthaeaeai?oeo caoai?thaaiue oe??e, ia?
o?ii?/iee ia?aa?a, ui oa?aeoa?eco?oueny ci?iith caaino?aiue ? ?ai?n?e.
*anoioa aeiaaee?a ini??aco a ??cieo iiioeyoe?yo aa??th?oueny – 0,5-3%
a?ae e?eueeino? ianaeaiiy (Parent D., Bernard B.A., Desbas C. et. all.,
1990); o i?ai?/ieo e?a?iao aiia aeua i?ae o i?aaeaiieo. Ca ia??iae
iaoeiaiai aeine?aeaeaiiy ini??aco iaeiie/aii aaeeeo e?euee?noue oaeo?a,
?ice?eoi ie?ai? eaiee iaoiaaiaco (Ii?aeiaoeaa A.I., Noa?eia E.A.,
Caaa?ianeee A.?. n niaao., 1987; Eth *.O., Oeie *.I., Aey A.Ae. n
niaao., 1990; Caaei?iaeiue A.A., sseiaoeiaa A.O., Aeauoe A.I. n niaao.,
1991; Aeauoe A.I., 1992; Aeiaaeaineee N.E., Oooe N.?., 1992; Iieeaiia
A.N., 1992; Eaaei I.I., Eaaei I.ss., *a?iuoia E.N. n niaao., 1996), aea
aei oeueiai /ano a?aenooiy a?iioaca, ui ioiieth? on? a?aeii? i?e
ini??ac? caeiiii??iino?. Iayai?noue oei/aniaiai aoaeoo iaoiaaiaoe/iiai
e?eoaaiiy, ui canoiniao?oueny, i?aeoaa?aeaeo? a?aeaeaeai?noue oeo
iaoiaaiaoe/ieo eaiie, ia ye? ?iaeyoue e?eoaaeueiee aieea, a?ae ii/aoeo
iaoiaaiaoe/iiai eaioethaa (Oaaeioia A.I., THueoei I.E., 1996).

Aaeeea cia/aiiy ?ioiieo ?aaeoe?e a iaoiaaiac? ini??aco (Iaoeeeeaenii
A.E., Oaooiaenoa? N.E., Oeueyiiaa E.I. n niaao., 1987; A?eoei O.I.,
Iaceia I.I., Ii?aeiaoeaa A.I. 1992; Aaeoaaaaa I.E., Oaieaeia O.E., 1996)
aei?aaaeiao? iiooe e?ea?nueeeo cania?a, ui aeathoue ?ioiiiiaeoethth/ee
aoaeo. I?aia?ao aetheai?i, ui canoiniaoaaany aeey e?eoaaiiy aooi?ioiieo
caoai?thaaiue niieo/ii? oeaieie, aeioe?eueii aeei?enoiaoaaoe aeey
e?eoaaiiy iioe?aieo oi?i ini??aco, eiee caiaeueia ?aaeoe?y
niinoa??aa?oueny o oe??? ia aaeee?e ieiu?. Iiaeaeueoa ?ic?iaea
iaoiaaiaco ? iiooe iiaeo, a?eueo aoaeoeaieo, cania?a a e?eoaaii? oai?eo
ia ini??ac ? aeooaeueiith oaiith.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?y aeeiiaia a?aeiia?aeii aei aea?aeaaii? eiiieaenii?
i?aea?aeii/i? i?ia?aie “I?io?eaeoeea caoai?thaaiue ? oi?ioaaiiy
caei?iaiai niiniao aeeooy ianaeaiiy Oe?a?ie ia ia??iae aei 2000 ?ieo”,
ieaio iaoeiaeo aeine?aeaeaiue eaoaae?e aea?iaoieia?? ? aaia?ieia??
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (? aea?ae?a?no?aoe??
019500234680).

Iaoa ? caaea/? aeine?aeaeaiiy.

Aea/eoe aoaeoeai?noue canoinoaaiiy eo?no ?i’?eoe?e ?ioiiiiaeoeyoi?a
aetheai?io aeey e?eoaaiiy iioe?aiiai ini??aco, a oaeiae aeine?aeeoe
aeaye? eaiee iaoiaaiaco ini??aco.

Noi?ioaaoe iniiaio a?oio oai?eo ia iioe?aiee ini??ac (aacenia e?eoaaiiy
+ aetheai?i) ? a?oio ii??aiyiiy (aacenia e?eoaaiiy), i?iaanoe ee?i?/iee
aiae?c o a?oiao.

Aea/eoe iaoiii?oieia?/i?, o o./. ?ioiiii?oieia?/i?, iniaeeaino?
a?iioao?a oe??e, ?ioiieia?/i? iieacieee e?ia?, a?io?i?/i? iniaeeaino?
oai?eo ia iioe?aiee ini??ac o aeaiue aini?oae?caoe??.

Aea/eoe aieea aeaioeaeiaaiai, aeiaeaoeiaiai aei, cae/aeiiai e?eoaaiiy ?c
canoinoaaiiyi aetheai?io ia iaoiii?oieia?/io, o o./. ?ioiiii?oieia?/io,
ea?oeio ini??aoe/iiai i?ioeano a a?iioaoao oe??e, ia ?ioiieia?/i?
iieacieee e?ia? ? a?io?i?/i? iniaeeaino? iaoaaie?cio.

Aea/eoe eiia??io iaoiaaiaoe/io ?ieue i?e ini??ac? ai?iii?a, ui aa?ooue
o/anoue a aaeaioaoe?? i?aai?cio aei no?ano ? a ?aaoeyoe??
ooieoe?iioaaiiy iaeaiioeeo?a oe??e.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a iieyaa? o aeei?enoaii?
eiiieaeniiai ee?i?ei-ii?oieia?/iiai aeine?aeaeaiiy (ee?i?/iee,
?ioiieia?/iee, a?io?i?/iee, iaoiii?oieia?/iee ? ?ioiiii?oieia?/iee, a
oaeiae ai?iiiaeueiee aiae?c), ui aeicaieeei i?iaeaiiino?oaaoe iayai?noue
iaoieia?/ieo ci?i a i?aai?ci? a oe?eiio. O oai?eo ia ini??ac
?icaeaa?oueny iaaei??ia aeoeaaoe?y i?ioean?a a?eueii-?aaeeeaeueiiai
ieeneaiiy e?i?ae?a, ci?ith?oueny e?i?aeiee niaeo? a?ieia?/ieo iaia?ai.
Aeoeai?noue aaia-aeooai?eo?ainoa?ace – oa?iaioo, yeee a?aeiia?aea? ca
o?ainii?o ai?iieeneio a na?aaeeio ee?oeie, o oai?eo ia ini??ac aea/aia
aia?oa, iieacaii cieaeaiiy aeoeaiino? oeueiai oa?iaioo.

Aia?oa aea/aii ai?no iaeaoii?io ? iaeaiioeeonoeioethth/iai ai?iiio a
e?ia? oai?eo ia ini??ac, ui i?e aiae?c? ?acii c ??aiai i?iaeoeoe?? ?ioeo
iaeai?i?aaoethth/eo ai?iii?a aeicaieeei iaa?oiooaaoe ?ieue oeeo ai?iii?a
o iaoiaaiac? ini??aco.

Aia?oa aeey e?eoaaiiy iioe?aiiai ini??aco aeei?enoaii ?ioiiiiaeoeyoi?
aetheai?i (AN ? 8278 A) ? iieacaii eiai aoaeoeai?noue: niinoa??aa?oueny
ca?eueoaiiy e?eueeino? O-noi?ani??a o ia?eaaneoey?ieo ?io?eueo?aoao
ina?aaeeo o?aaeaiiy, aeoeaaoe?y ee?oei Eaiaa?aaina a ai?aea?i?n?,
ciaioaiiy e?eueeino? eaeeioeeo?a, ui ianooue HLA-Dr aioeaai, ciaioaiiy
nooiaiy eaeeioeeoico c? ciaioaiiyi ai?noo o e?ia? O- ? A-e?ioioeeo?a,
iaeo?io?e?a, ui oaaioeeoothoue. A?io?i?/ii aeyaeaii aioeieneaeaioio ?
iaia?aiinoaa?e?coth/o ae?th aetheai?io i?e aeei?enoaii? eiai aeey
e?eoaaiiy oai?eo ia iioe?aiee ini??ac.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Aeina?ae iayaiino? iiceoeaiiai aoaeoo aeei?enoaiiy aetheai?io a
e?eoaaii? iioe?aiiai ini??aco aeicaiey? ?aeiiaiaeoaaoe eiai aeey
oe?ieiai canoinoaaiiy a aea?iaoieia??.

?acoeueoaoe aea/aiiy ai?iiiaeueieo eaiie iaoiaaiaco ini??aco ?iaeyoue
iiaeeeaei iiaeaeueoee i?aeoe/iee iiooe cania?a, ui aieeaathoue ia aeai?
eaiee iaoiaaiaco

Iniaenoee aianie aeena?oaioa.

Ianoaaeaiiy oai?eo ia ii/aoeo, a ia?aa?c? ? a e?ioe? ia??iaeo
aini?oae?caoe??; iaienaiiy iaeyaeo e?oa?aoo?e, caa?? iaoa??aeo aeey
aeine?aeaeaiiy, noaoenoe/ia ia?iaea ? aiae?c ?acoeueoao?a
aeine?aeaeaiiy, ocaaaeueiaiiy ?acoeueoao?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

Iaoa??aee ?iaioe aoei aeieeaaeaii ? iaaiai?aii ia eiioa?aioe?? iieiaeeo
o/aieo OAeIO o ea?oi? 1997 ?., ia can?aeaii? oiaa?enoaa
iaoieiaiaiaoii?a i. Oa?eiaa o ethoiio 1998 ?., ia i?aeiaeani?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? i?iaeaie iaoieia?? a
aeieia?/ieo oiiaao Neiaiaeaiueie” o /a?ai? 1998 ?., i. Noie.

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ae?oeiaaieo ?ia?o, ?c yeeo 4
– o iaoeiaeo ? iaoeiai-i?aeoe/ieo aeo?iaeao, 1 – o iaoeiaiio
iiiioaiaoe/iiio ca??ieeo, 2 – o iaoa??aeao iaoeiaeo eiioa?aioe?e, 1 –
iaoaio ia aeiao?ae AN ? 8278 A.

No?oeoo?a oa ianya aeena?oaoe??.

?iaioa aeeeaaeaia ia 172 noi??ieao iaoeiiieniiai oaenoo. Neeaaea?oueny
?c anooio, iaeyaeo e?oa?aoo?e, /anoeie c ee?i?/iith oa?aeoa?enoeeith
oai?eo ? iienii iaoiae?a aeine?aeaeaiiy, 4-o /anoei ?c ?acoeueoaoaie
aeanieo aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiiy,
aeniiae?a, ia?ae?eo aeei?enoaieo aeaea?ae iaoeiai? e?oa?aoo?e, yeee
aeeth/a? 237 oe?a?inueei- ? ?in?enueeiiiaieo ? 53 ?iicaiieo aeaea?ae,
onueiai 290. ?ethno?aoeaia /anoeia i?aaenoaaeaia 21 oaaeeoeath ? 40
iaethieaie, o o./. 38 i?e?ioioia?ao?yie (ia’?iii 45 noi?.).

CI?NO ?IAIOE

Ee?i?/ia oa?aeoa?enoeea oai?eo ? iaoiaee aeine?aeaeaiiy.

I?ae niinoa?aaeaiiyi ciaoiaeeeiny 107 oai?eo ia iioe?aiee ini??ac (5-e
OAAe i. Oa?eiaa, Oa?e?anueeee iaeaniee OAAe): 49 oai?eo neeaee iniiaio
a?oio, 58 – a?oio ii??aiyiiy. Oai?? a?oie ii??aiyiiy io?eioaaee
noaiaea?oia e?eoaaiiy ini??aco, yea aeei?enoiao?oueny a aeaieo
caeeaaeao. Oea i?ioecaiaeuei?, aioea?noai?ii?, o?aiea?e?coth/? caniae,
a?oai?iioa?ai?y, i?noeaaa oa?ai?y. Oai?? iniiaii? a?oie aeiaeaoeiai aei
cae/aeii? noaie e?eoaaiiy uiaeaiii io?eioaaee aioo??oiueii’ycia?
?i’?eoe?? 20% ?ic/eio aetheai?io (eo?n 14 ?i’?eoe?e), yeee ia?
?ioiiiiaeoethth/? aeanoeaino?.

A?oie oai?eo ia ini??ac (iniiaia ? ii??aiyiiy) aiaeia?/i? ca noaooth
(aeii?iothoue /ieia?ee), a?eii (ia?aaaaeathoue a ?ioa?aae? 35-40 ?ie?a),
ee?i?/iei ae?aaiicii (iioe?aiee ini??ac), o?eaae?noth caoai?thaaiiy (a
na?aaeiueiio i?eaeecii 10 ?ie?a), ia’?eoeaiei noaoonii, ee?i?/ieie
eaai?aoi?ieie aeaieie, ui ?iaeoue i?aaii??iei aea/aiiy aoaeoeaiino?
canoinoaaiiy aetheai?io a e?eoaaii? ini??aco i?e ii??aiyii? ?acoeueoao?a
e?eoaaiiy o noi?iiaaieo a?oiao.

O oai?eo ia aeaiue aini?oae?caoe?? e ia 15-e aeaiue e?eoaaiiy i?iaiaeeee
caa?? a?iioao?a (o 19 oai?eo iniiaii? a?oie e 17 oai?eo a?oie
ii??aiyiiy) c ia?eoa??? ina?aaeeo o?aaeaiiy i?ae i?noeaaith aianoac??th
0,5% ?ic/eiii iiaiea?io. Ii?oieia?/iei eiio?ieai noaee oiaoi/ee oe??e,
aen?/ai? c iiaa?oi? ooeoaa e ?icaeiaeueieo iiaa?oiiue aa?oi?o ? ieaei?o
e?ioe?aie 10 i?aeoe/ii caei?iaeo ethaeae, ye? caaeioee a
aei?iaeiuei-o?ainii?oieo aaa??yo (i?icaeoo?a 4-? i?nueei? e?ea?i?
oaeaeei? aeiiiiiae i. Oa?eiaa). Aeei?enoiaoaaeeny oae? a?noieia?/i? oa
a?noio?i?/i? ie?ane: aaiaoienee?iii-aiceiii, i?e?iooeneiii ca Aai
A?ciiii, ia AeIE ca Oaeueaaiii-?innaiaaeii, ia ?IE ca A?aoa (c
eiio?ieai – ia?iaeith ??aiioeeaacith), ca Aaeaeaiaaeiii a iiaeeo?eaoe??
?aai, Oeoo-eiaeiith eeneioith ? ca Iaeei??.

Iioe/io u?euei?noue (Oaoey E. 1980) yaea? aacaeueiiai e oeioaaoiai oa??a
ai?aea?i?no i?e ie?anoe? ia AeIE ca Oaeueaaiii-?iinnaiaaeii aecia/aee ia
oeeoioioiiao?? c OIAE 1a (EIII). I?e aeeiiaii? aeaii? ?iaioe
cai?iiiiiaaiee ? aeei?enoaiee ii?oiiao?e/iee iieaciee “ieoiia aeiaaeeia
aacaeueii? iaia?aie ai?aea?i?no” aeey ia’?eoea?caoe?? nooiaiy
a?ia?i?ie?oa?aoe?? ai?aea?i?no. Ia oeeoieia?/iiio aiae?caoi?? “?ioaa?ae
– 2IO” (Ee?a) aei??thaaeany aeiaaeeia c??co a?iioaoo oe??e ia ??ai?
aacaeueii? iaia?aie e aeiaaeeia aacaeueii? iaia?aie ai?aea?i?no ia
aeaiiio c??c?. Ia?a?ic?aooiie aeiaaeeie aacaeueii? iaia?aie ai?aea?i?no
aeaiiai c?acea oe??e a?aeiinii 1ni eiai aeiaaeeie e aea? cia/aiiy
iieacieea “ieoiia aeiaaeeia aacaeueii? iaia?aie ai?aea?i?no”.

?ioiiii?oieia?/i? aeine?aeaeaiiy i?iaiaeeee ia ia?ao?iiaeo c??cao
oiaueiith 5-6iei iai?yiei iaoiaeii Eoina ca iaoiaeeeith Brosman. ?ioii?
ee?oeie aeeoa?aioe?thaaee ca aeiiiiiaith ieoa/eo iiiieeiiaeueieo aioeo?e
(IEA) aei ??cieo oei?a ee?oei na??? ?EI-III “Iaaea?iniaeo?”.
Aeei?enoiaoaaee ?EI-31 (CD8), -86 (CD4), -90 (CD3), -12 (CD22), -?
(HLA-Dr), -20 (CD38), -AI? (CD11b), -56 (CD45), -60 (CD18). Eieaaaie
oeioaaee IEA aei eieaaai?a I, III, IV, V oei?a. O yeino?
ethi?ianoeaioii? iicia/ee aeei?enoiaoaaee F (ab)-2 – o?aaiaioe iii?/aieo
O?OOe e?iey/eo aioeo?e i?ioe ?ioiiaeiaoe?i?a ieo?. I?aia?aoe aea/aee a
ethi?ianoeaioiiio i?e?ineii? ETHIAI E2 c aeei?enoaiiyi na?oeio?eueo??a:
ON-1-2, NCN-24, AN-8-2, OON-6-3.

Caa?? e?ia? ia ?ioiieia?/ia aeine?aeaeaiiy i?iaiaeeee a ?aieia? aiaeeie
iaouana?oea c e?eoueiai? aaie. Aea/aee ?yae ia?aiao??a, ye?
oa?aeoa?ecothoue ianiaoeeo?/io ?acenoaioi?noue (oaaioeeoa?ia aeoeai?noue
iaeo?io?e?a ia?eoa?e/ii? e?ia?) ? noai ee?oeiii? oa aoii?aeueii? eaiie
?ioi?oaoo. Eaeeioeeoa?io oi?ioeo ioe?ithaaee caaaeueiii?eeiyoeie
eaai?aoi?ieie iaoiaeaie.

E?euee?noue O-caaaeueieo e?ioioeeo?a aecia/aee a ?aaeoe?? niiioaiiiai
?icaoeiooai?aiiy (A-?IE) c a?eo?ioeeoaie aa?aia, e?euee?noue
A-e?ioioeeo?a o o?e aea ?aaeoe?? c a?eo?ioeeoaie ieo? (*a?aaeaaa A.I.,
1976). Ia/eneaiiy e?eueeino? O-noi?ani??a i?iaiaeeee iaoiaeii
oa?iinoaa?eueieo ?icaoie c a?eo?ioeeoaie aa?aia (Olinesku A., Hristescu
S., Roman S., 1987).

??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) aecia/aee
niaeo?ioioiiao?e/iei iaoiaeii oeyoii i?aoeei?oaoe?? a 3,5% ?ic/ei?
iie?ao?eaiae?eiey (A?eiaae/ TH.A., Aeoa?ia A..E., 1981). Ai?no
?ioiiaeiaoe?i?a iniiaieo eean?a (IgM, A, G) a ne?iaaooe? e?ia? aecia/aee
iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca Iai/ei? c aeei?enoaiiyi
eiia?oe?eieo iiiiniaoeeo?/ieo ne?iaaoie i?ioe ?ioiiaeiaoe?i?a ethaeeie
ae?iaieoeoaa Ieaeiueiai?iaenueeiai IAe? ai?aeai?ieia?? oa i?e?ia?ieia??.
Oaaioeeoa?io aeoeai?noue iaeo?io?e?a ia?eoa?e/ii? e?ia? ioe?ithaaee
iaoiaeii caaa?oaiiai oaaioeeoico a i?yiiio a?coaeueiiio oano?
(Eoae?yaeoeeee A.E., 1985).

Aeey aeyaeaiiy a?io?i?/ieo iniaeeainoae i?e ini??ac? i?iaiaeeee ianooii?
aeine?aeaeaiiy: aecia/aiiy a ne?iaaooe? e?ia? aeoeaiino? oea?oeiieaci?io
(Aaaaiei A.I., 1968), eaeoaoaeaa?ae?iaaiace (I?ioi?iaa I.E., 1982),
iaeaoaeaa?ae?iaaiace (Iiaeeeue/ae I.O., 1964), eaoaeace (Ia?eoaon ?.,
Niai Aeae., Eeiaeo O. n niaao., 1983), ia?ieneaeace (Anaoeaie A.N.,
1969). E??i oiai, i?iaiaeeeinue aecia/aiiy SH-a?oi e?ia? (Naaa?ei N.A.,
Nieiaueaaa A.A., 1989), aeooao?iio (I?ioi?iaa I.E., 1982). Noai
a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a aea/aany ca aeiiiiiaith iaoiaeo
iaaeneaaeiai na?o?iiy (AEo?aaeaa A.E., AEo?aaeaaa A.E., 1975) ia
oai?ethi?iiiao?? iaaee/iiio OEIO 1-01.

Aoiiii-aani?aoe?eiei iaoiaeii (A?eoeea I.A., 1982) aeine?aeaeoaaany
ai?no o ne?iaaooe? e?ia? i?ae?, oeeieo, cae?ca, iaai?th, eae?th,
iao??th, eaeueoe?th ia aoiiii-aani?aoe?eiiio niaeo?ioioiiao?? “Naoo?i”.
Noai iaia?ai ee?oeie aea/aany oeyoii aecia/aiiy oaeaeeino? aeoiaeo
eae?th c a?eo?ioeeo?a (Aoaneee A.E., I?ioeaiei A.I., 1970) ? aecia/aiiy
oinoie?i?ae?a (Ee?oia? TH., 1981). Aiae?coaaee ai?no o ne?iaaooe? e?ia?
aaioiaeia?io – aioeieneaeaioo e eiiieaeniooai?thaa/a (A?oeiiaa I.A.,
Oeoeeay I.I., Naiaiiaa E.N., 1988).

Aecia/aee aeoeai?noue oie?ianoa?ace e?ia? (Anaoeaie A.N., 1969),
aeai?iiai? ? ania?aa?iiai? ai?iio?ainoa?ac (?aoiaoia A.A., Aiaoe O.E.,
1991), eoaeii? oinoaoace e e?aaoeioinoie?iace (Iiae?eue/ae I.O., 1964).
Aeoeai?noue oa?iaio?a aeooao?iiia?ieneaeace, aaia-aeooai?eo?ainoa?ace,
aeueoa-a?ae?ieneaooe?aoaeaa?ae?iaaiace aeine?aeaeoaaee ca aeiiiiiaith
iaai??a ?aaeoea?a o??ie Labsystems (O?ieyiae?y) ca ?ino?oeoe?yie, ui
aeiaeathoueny, niaeo?ioioiiao?e/ii (NO-46).

Ai?no ai?iieeneio o ne?iaaooe? e?ia? aea/aee iaoiaeii ?iiiiai?iii?
o?iiaoia?ao?? ia aaoiiaoe/iiio aiae?caoi?? ai?iieeneio AAA-339 (Ci?ueeei
A.A., Eo?oea? A.I., Aeiaaaineee A.I., 1985).

Ai?iiiaeuei? aeine?aeaeaiiy e?ia? oai?eo o aeai?e ?iaio? cae?eniaii
aeaiia niiniaaie: ?aae?i?ioiieia?/iei ia RIA-iaai?ao (iaeaoii?i- ?-125,
INA – ?-125, AEOA – ?-125, ei?oecie – ?-125) – aiae?c ia onoaiiaoe? aeey
?aae?i?ioiio?i?/ieo aeine?aeaeaiue “Aaiia-800” e aae?aiae?i,
ii?aae?aiae?i ? na?ioii?i iaoiaeii eieiieiai? o?iiaoia?ao?? (Colin,
1978) c ianooiiei oethi?eiao?e/iei aiae?cii (Hithachi).

Noaoenoe/ia ia?iaea oeeo?iaeo ?acoeueoao?a i?iaiaeeeany iaoiaeaie
aa??aoe?eiiai ? ei?aeyoe?eiiai aiae?c?a c aeei?enoaiiyi AII “Pentium”.

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe, ?O AIAE?C E IAAIAI?AIIss.

Caa?? a?iin?eiiai iaoa??aeo c ia?eoa??? ina?aaeeo o?aaeaiiy oe??e a 1-e
aeaiue aini?oae?caoe?? e ii??aiyeueia c iao?aaeaiith oe??ith aea/aiiy
i?e?ineii?/ieo i?aia?ao?a aeicaiey? aeyaeoe o oai?eo on? aaaaoi?aciai
iienai? a iaoeia?e e?oa?aoo?? (Oeaaoeiaa A.I., 1981, Eiiueaaa O.I.,
Aeaaeeie?ia A.A., 1983; Ii?aeiaoeaa A.I., 1986; Oeiiia A.A., Oaa/aiei
O.E., 1987; Aeauoe A.I., 1992) iaoiaiiiii?/i? iciaee ini??aco:
a?ia?i?ie?oa?aoe?th e iaaeinoaoi? aeeoa?aioe?thaaiiy ai?aea?iioeeo?a,
aeaioic, iineeaio i?a?aoe?th iie?ii?oiiyaea?ieo eaeeioeeo?a oa
iae?ioaa?a (ee?oei Eaiaa?aaina) a eieone ia?aea?aoico c ooai?aiiyi
aanoean?a Ioi?i, oi?ioaaiiy eaioethaa aooi?ioiieo ?aaeoe?e ia
ai?aea?iaeuei? a?eee c i?a?aoe??th O- ? A-e?ioioeeo?a o ia?eeai?ey?i?
i?inoi?e aea?ie ? c a?ia?i?iaeoeoe??th ?ioiiaeiaoe?i?a, a iio?i ? Oe?E,
ye? a?aeeeaaeathoueny ia aacaeueieo iaia?aiao noaeei
i?e?ioee?eoeyoi?iiai ?onea aea?ie. Iaa?ye ? a?iioiene/iee noai
ciai?oiueiai oa?o aea?ie iaoiiaeththoue i?ioeane iae?ia?ico iniiaii?
?a/iaeie e aieieii aea?ie, ui noa? ii/aoeii iiaiai eaioethaa aooi?ioiii?
?aaeoe?? ia a?eee aea?ie.

?ioiiii?oieia?/ia aeine?aeaeaiiy oe??e e ?ioiieia?/ia aeine?aeaeaiiy
e?ia? i?aeoaa?aeaeothoue i?aaenoaaeaiee ii?yaeie ?icai?oaiiy iiae?e.
Niinoa??aaee ciaioaiiy e?eueeino? O-noi?ani??a o ia?eaaneoey?ieo
?io?eueo?aoao aea?ie, e?cen ? iaineioac eieaaai?a o aacaeueieo iaia?aiao
? niieo/i?e oeaiei?, ae?aaeaiee eaeeioeeoic ? ca?eueoaiiy e?eueeino?
oaaioeeooth/eo iaeo?io?e?a e aaeoa?eoeeaeii? ?ieino? e?ia?,
a?ia?aeiaoe?iai?th. A?aecia/aia o oai?eo ia ini??ac aeoeaoaaiiy IIE
i?ecaiaeeoue aei aeniaaeaiiy aioeieneaeaioii? nenoaie, ii?ooaiiy
no?oeoo?e e i?iieeeeaino? iaia?ai, ci?ie aeoeaiino? aaaaoueio oa?iaio?a,
ia?a?icae?eo i?e?iaeaiaio?a; noeoii?noue oeeo i?ioean?a i?ecaiaeeoue aei
aeeaieiai ii?ooaiiy a?eeiaiai, aoaeaaiaeiiai e aee?iaiai iai?i?a.

Ieoaiiy i?i ?i?oe?thth/ee i?ie?oa?aoe?th ai?aea?i?na iiiaio ia aeaiee
/an ia ae??oaii. O iaoiio ?icii?yaeaeaii? ? aeayea e?euee?noue
e?oa?aoo?ieo ? aeanieo oaeo?a, ye? na?ae/aoue i?i aacoiiaio i?e/aoi?noue
iaeai?io aei iaoai?cio ini??aoe/iiai i?ioeano.

Aiae?c ?acoeueoao?a aecia/aiiy ai?noo a e?ia? oeacaieo aeua ai?iii?a
iieacaa, ui o an?o oai?eo ia iioe?aiee ini??ac a noaae?? i?ia?an?? ia?
i?noea ?noioia a?ia?aae?aiae?iai?y oa a?iiii?aae?aiae?iai?y,
a?ia?na?ioii?iai?y oa a?iiiaeaoii?iai?y, ye i?aeaeuaiiy, oae ? cieaeaiiy
ai?noo a e?ia? INA, iayai?noue AEOA ? ei?oecieo ia ieaeiueiio ??ai?
ii?ie aai ieae/a eiai. Aecia/aiiy ni?aa?aeiioaiiy ai?iii?a o ia?ao
aae?aiae?i-ii?aae?aiae?i, na?ioii?i-iaeaoii?i, iaeaoii?i-INA
i?aeoaa?aeaeo? ?o aca?iica’ycie e ?noioio ?ieue ?o ii?ooaiiy a
iaoiaaiac? ini??aco. Iiooe iiaeeeaiai ii/aoeo eaioethaa ai?iiiaeueieo
ci?i coieiea iaoo oaaao ia aae?aiae?i?, ai?iii?, yeee aeoeaii
aeae?ey?oueny iiceiaith ?a/iaeiith iaaeie?iee?a a oiiaao no?ano. O?eaaea
a?ia?aae?aiae?iai?y iiaea iioyaoe ca niaith a?iiii?aae?aiae?iai?th,
ine?eueee ii?aae?aiae?i ooai?th?oueny c aae?aiae?io. Ii?aae?aiae?i, ye
a?aeiii (Neaiooeei A.Ae., Iaoeineee A.A., 1982), caaacia/o? o?ainii?o
o?eioioaio a ai?iiiaeueii aeoeaio ee?oeio ai?o?co iiceo e ca?eueoaiiy
ooai?aiiy oeeee?/iiai aaeaiiceiiiiioinoaoo, yeee ae?? ia aoeaoeethaaiiy
na?ioii?io e ia?aoai?aiiy eiai a N-aoeaoeena?ioii?i ? aeae? o iaeaoii?i.
Oiaoi a neooaoe??, yea aiae?co?oueny, aeao?oeeo ii?aae?aiae?io cao?eio?
ooai?aiiy iaeaoii?io ?c na?ioii?io, ? niinoa??aa?oueny ia?aeaeueii
a?ia?na?ioii?iai?y e a?ia?iaeaoii?iai?y. Na?ioii?i noeioeth?
i?iaeoeoe?th AEOA, yea a oiiaao no?ano e oae aoea aaea a noai?
noeioethaaiiy. Oiio, i/aaeaeii, ianoa? oaeaeea ae/a?ii?noue
AEOA-i?iaeoeooth/eo ee?oei aaeaiia?iio?co ? i?ney oeueiai – iecueea aai
ia iecuee?e iaae? ii?ie i?iaeoeoe?y ei?oecieo. I?e ae/a?iiino? ooieoe??
AEOA – i?iaeoeooth/eo ee?oei eiiiainaoi?ii ianoa? a?ia?i?iaeoeoe?y INA,
ine?eueee iaeaeaa oe? ai?iiie neioacothoueny ?c caaaeueiiai aeaea?aea e
ooieoe?? /anoeiai ia?ao?auothoueny, cie?aia, AEOA caeaoiee iineeeoe
neioac iaeai?io a iaeaiioeeoao (Hunt G., Togg C., Kyne S., at all.,
1994). Oaeiae oe?iei a?aeiiee oaeo iinea?iiy i?ney neeueieo no?an?a,
oiaoi no?an i?ecaiaeeoue aei ae/a?iiino? noanoaioe?e, noeioethth/eo
ooai?aiiy iaeai?io o aieinyieo oeeaoeeiao.

Ca?aeii c iaea?aeaieie o aeaiiio aeine?aeaeaii? oeeo?aie, i?iaeoeoe?y
AEOA o noai? aeniaaeaiiy, a INA – o a?eueoino? aeiaaee?a o noai? aeniei?
eiiiainaoi?ii? iai?oae, ??aeoa – aeniaaeaiiy. Oiio iiaeia ia?aaeaa/eoe
cieaeaiiy neioaco iaeai?io a iaeaiioeeoao oe??e. A iecueeee ??aaiue
i?iaeoeoe?? iaeaoii?io a ai?o?c? iiceo iaoiiaeth? i?a?aoe?th ooai?aieo a
iaeaiioeeoao o ciaioai?e e?eueeino? iaeaiinii o i?aeee?oeiiiio i?inoi??,
aea aiie caoiieththoueny o ia?oo /a?ao ee?oeiaie Eaiaa?aaina. A?aeiii,
ui iayai?noue iaei? e?eueeino? iaeaiinii o ee?oei? Eaiaa?aaina
ii?aeio?oueny c? cieaeaiiyi i?iaeoeoe?? ieie eaeeii?a (O?ieia A.I.,
1982), a aiie i?yii aaeueiothoue i?ie?oa?aoe?th aacaeueieo
ai?aea?iioeeo?a, oiaoi oaeei /eiii iiaea aeieeiooe a?ia?i?ie?oa?aoe?y
ai?aea?iioeeo?a c on?ia ianooiieie i?ioeanaie.

Ia noai? i?aaenoaaeaia aaeocea ai?iiiaeueii-oe??ieo ca’yce?a,
aeeeaaeaieo a aeai?e a?iioac?.

Aeaa oeaei? e?eoaaiiy oai?eo ia iioe?aiee ini??ac ?c a?oie ii??aiyiiy,
oiaoi ?c canoinoaaiiyi i?ioecaiaeueieo, aeanainea?e?coth/eo,
o?aiea?e?coth/eo i?aia?ao?a, a?oai?iioa?ai??, ciai?oiuei?, a o./.
i?noeaai?, oa?ai??, ? c iniiaii? a?oie, oiaoi c aeiaeaoeiaei
aeei?enoaiiyi aetheai?io, iaoiiaeee oae? ?acoeueoaoe.

Ciaeaeaii, ui i?eaeecii o iaeiaeiai? /anoeie oai?eo iaio a?oi ia? i?noea
ae?acia ?aa?an?y iaoiii?oieia?/ieo iciae, o /anoeie – niinoa??aa?oue-ny
noaa?e?caoe?y, o /anoeie eaea iiaeaeueoa i?ia?anoaaiiy iaoieia?/iiai
i?ioea-no. Iaeiae canoinoaaiiy ii?oiiao?e/iiai iieacieea “e?euee?noue
ee?oei Eai-aa?aaina ia 10 ee?oei aacaeueiiai oa oeioaaoiai oa??a
ai?aea?i?no” (ca?eue-oaiiy cia/aiiy), ?ioiiii?oieia?/ieo iieaciee?a
(i?aeaeuaiiy CD8-noi?a-ni?ii? aeoeaiino? a ia?eaaneoey?ieo ?io?eueo?aoao
aea?ie, a?eueo iii?oia ciaioaiiy e?eueeino? eaeeioeeo?a c HLA-Dr
aioeaaiii), aiae?c ee?i?/ieo ?ioiieia?/ieo iieaciee?a (a?eueo ae?acia
ciaioaiiy ai?noo ??cieo aeae?a eaeeioeeo?a a iaeeieoe? ia’?io e?ia?, o
o./. O- ? A-e?ioioeeo?a, oaaioeeooth/eo iaeo?io?e?a) ia’?eoeaii
i?aeoaa?aeeee a?eueoo oni?oi?noue aeai-oeaeiaaiai e?eoaaiiy oai?eo ia
iioe?aiee ini??ac c iniiaii? a?oie.

I?iaaaeaia aeai-oeaeiaaa e?eoaaiiy i?ecaaei aei nooo?aiai cieaeaiiy
?ioaineaiino? IIE ye a iniiai?e a?oi?, oae ? a a?oi? ii??aiyiiy. Iaeiae
a iniiai?e a?oi? ci?ie a?eueo ae?aaeai?. O oai?eo iniiaii? a?oie
aeinoia??ii cieaeo?oueny ai?no SH-a?oi, o oie /an, ye o oai?eo a?oie
ii??aiyiiy oeae iieaciee i?aeoe/ii ia ci?ith?oueny (oaae. 1, 2).

Oaaeeoey 1

Noai a?eueii-?aaeeeaeueiiai ieeneaiiy e?i?ae?a o oai?eo ia ini??ac
ii??aiyii c aeiii?aie

A?oie

Niinoa?aaeai. Iieacieee (M+m)

IAeA (ieI/e) Ae??iia? eii’thaaoe (ieI/e) ?ioaineai?noue AOE (1/nae)

Aeiii?e

N=105 8.11+0.29 59.97+2.72 650+25

A?oia ii??aiyiiy aei e?eoaaiiy n=45 22.1+2.0 p0.1
60.27+3.08 p>0.1 p20.1
0.73+0.05 p0.1 p2>0.1 1.64+0.1 p

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