IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO ?I. I.I.AIAIIIEUeOess

A ? I O A I E A I A A I A O I E ? ? A I A

OAeE: 616.517-085.37

AETHEAI?I O EIIIEAENI?E OA?AI?? OAI?EO IA INI??AC

— oe??i? oa aaia?e/i? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

i. Ee?a — 1998 ?.

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee — aeieoi? iaaee/ieo iaoe, i?ioani? Aeauoe Aiae??e
Ieoaeeiae/, Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee
eaoaae?ith oe??ieo oa aaia?e/ieo oai?ia.

Iaoeiaee eiinoeueoaio — caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,
aeieoi? iaaee/ieo iaoe, i?ioani? sseiaoeiaa Aioii?ia Oaaei??aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoth/ee eaoaae?ith
iaoieia?/ii? aiaoii??.

Io?oe?ei? iiiiaioe: — aeieoi? iaaee/ieo iaoe, i?ioani? Eyoaiei ?aai
Ieeeoi?iae/, A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.
I.?.Ie?iaiaa, i?ioani? eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.

— eaiaeeaeao iaaee/ieo iaoe, aeioeaio
Ooiaiueei Ieeiea Ieoaeeiae/, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.
I.I.Aiaiiieueoey, aeioeaio eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i. I.E.Ooieea.

Caoeno a?aeaoaeaoueny “21” n?/iy 1999 ?. i 13-30 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.02 i?e Iaoe?iiaeueiiio
iaaee/iiio oi?aa?neoao? ?i. I.I.Aiaiiieueoey ca aae?anith: 252004, i.
Ee?a, a. Oaa/aiei, 13.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey ca aae?anith: 252004, i.
Ee?a, a. Oaa/aiei, 13.

Aaoi?aoa?ao ?ic?neaiee “ 11 ” a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Ae.i.i., aeioeaio NAE?EAe N.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie.

Ini??ac ? iaeiei c iae?iciianthaeaeai?oeo caoai?thaaiue oe??e, ia?
o?ii?/iee ia?aa?a, ui oa?aeoa?eco?oueny ci?iith caaino?aiue ? ?ai?n?e.
*anoioa aeiaaee?a ini??aco a ??cieo iiioeyoe?yo aa??th?oueny — 0,5-3%
a?ae e?eueeino? ianaeaiiy (Parent D., Bernard B.A., Desbas C. et. all.,
1990); o i?ai?/ieo e?a?iao aiia aeua i?ae o i?aaeaiieo. Ca ia??iae
iaoeiaiai aeine?aeaeaiiy ini??aco iaeiie/aii aaeeeo e?euee?noue oaeo?a,
?ice?eoi ie?ai? eaiee iaoiaaiaco (Ii?aeiaoeaa A.I., Noa?eia E.A.,
Caaa?ianeee A.?. n niaao., 1987; Eth *.O., Oeie *.I., Aey A.Ae. n
niaao., 1990; Caaei?iaeiue A.A., sseiaoeiaa A.O., Aeauoe A.I. n niaao.,
1991; Aeauoe A.I., 1992; Aeiaaeaineee N.E., Oooe N.?., 1992; Iieeaiia
A.N., 1992; Eaaei I.I., Eaaei I.ss., *a?iuoia E.N. n niaao., 1996), aea
aei oeueiai /ano a?aenooiy a?iioaca, ui ioiieth? on? a?aeii? i?e
ini??ac? caeiiii??iino?. Iayai?noue oei/aniaiai aoaeoo iaoiaaiaoe/iiai
e?eoaaiiy, ui canoiniao?oueny, i?aeoaa?aeaeo? a?aeaeaeai?noue oeo
iaoiaaiaoe/ieo eaiie, ia ye? ?iaeyoue e?eoaaeueiee aieea, a?ae ii/aoeo
iaoiaaiaoe/iiai eaioethaa (Oaaeioia A.I., THueoei I.E., 1996).

Aaeeea cia/aiiy ?ioiieo ?aaeoe?e a iaoiaaiac? ini??aco (Iaoeeeeaenii
A.E., Oaooiaenoa? N.E., Oeueyiiaa E.I. n niaao., 1987; A?eoei O.I.,
Iaceia I.I., Ii?aeiaoeaa A.I. 1992; Aaeoaaaaa I.E., Oaieaeia O.E., 1996)
aei?aaaeiao? iiooe e?ea?nueeeo cania?a, ui aeathoue ?ioiiiiaeoethth/ee
aoaeo. I?aia?ao aetheai?i, ui canoiniaoaaany aeey e?eoaaiiy aooi?ioiieo
caoai?thaaiue niieo/ii? oeaieie, aeioe?eueii aeei?enoiaoaaoe aeey
e?eoaaiiy iioe?aieo oi?i ini??aco, eiee caiaeueia ?aaeoe?y
niinoa??aa?oueny o oe??? ia aaeee?e ieiu?. Iiaeaeueoa ?ic?iaea
iaoiaaiaco ? iiooe iiaeo, a?eueo aoaeoeaieo, cania?a a e?eoaaii? oai?eo
ia ini??ac ? aeooaeueiith oaiith.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?y aeeiiaia a?aeiia?aeii aei aea?aeaaii? eiiieaenii?
i?aea?aeii/i? i?ia?aie “I?io?eaeoeea caoai?thaaiue ? oi?ioaaiiy
caei?iaiai niiniao aeeooy ianaeaiiy Oe?a?ie ia ia??iae aei 2000 ?ieo”,
ieaio iaoeiaeo aeine?aeaeaiue eaoaae?e aea?iaoieia?? ? aaia?ieia??
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (? aea?ae?a?no?aoe??
019500234680).

Iaoa ? caaea/? aeine?aeaeaiiy.

Aea/eoe aoaeoeai?noue canoinoaaiiy eo?no ?i’?eoe?e ?ioiiiiaeoeyoi?a
aetheai?io aeey e?eoaaiiy iioe?aiiai ini??aco, a oaeiae aeine?aeeoe
aeaye? eaiee iaoiaaiaco ini??aco.

Noi?ioaaoe iniiaio a?oio oai?eo ia iioe?aiee ini??ac (aacenia e?eoaaiiy
+ aetheai?i) ? a?oio ii??aiyiiy (aacenia e?eoaaiiy), i?iaanoe ee?i?/iee
aiae?c o a?oiao.

Aea/eoe iaoiii?oieia?/i?, o o./. ?ioiiii?oieia?/i?, iniaeeaino?
a?iioao?a oe??e, ?ioiieia?/i? iieacieee e?ia?, a?io?i?/i? iniaeeaino?
oai?eo ia iioe?aiee ini??ac o aeaiue aini?oae?caoe??.

Aea/eoe aieea aeaioeaeiaaiai, aeiaeaoeiaiai aei, cae/aeiiai e?eoaaiiy ?c
canoinoaaiiyi aetheai?io ia iaoiii?oieia?/io, o o./. ?ioiiii?oieia?/io,
ea?oeio ini??aoe/iiai i?ioeano a a?iioaoao oe??e, ia ?ioiieia?/i?
iieacieee e?ia? ? a?io?i?/i? iniaeeaino? iaoaaie?cio.

Aea/eoe eiia??io iaoiaaiaoe/io ?ieue i?e ini??ac? ai?iii?a, ui aa?ooue
o/anoue a aaeaioaoe?? i?aai?cio aei no?ano ? a ?aaoeyoe??
ooieoe?iioaaiiy iaeaiioeeo?a oe??e.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a iieyaa? o aeei?enoaii?
eiiieaeniiai ee?i?ei-ii?oieia?/iiai aeine?aeaeaiiy (ee?i?/iee,
?ioiieia?/iee, a?io?i?/iee, iaoiii?oieia?/iee ? ?ioiiii?oieia?/iee, a
oaeiae ai?iiiaeueiee aiae?c), ui aeicaieeei i?iaeaiiino?oaaoe iayai?noue
iaoieia?/ieo ci?i a i?aai?ci? a oe?eiio. O oai?eo ia ini??ac
?icaeaa?oueny iaaei??ia aeoeaaoe?y i?ioean?a a?eueii-?aaeeeaeueiiai
ieeneaiiy e?i?ae?a, ci?ith?oueny e?i?aeiee niaeo? a?ieia?/ieo iaia?ai.
Aeoeai?noue aaia-aeooai?eo?ainoa?ace – oa?iaioo, yeee a?aeiia?aea? ca
o?ainii?o ai?iieeneio a na?aaeeio ee?oeie, o oai?eo ia ini??ac aea/aia
aia?oa, iieacaii cieaeaiiy aeoeaiino? oeueiai oa?iaioo.

Aia?oa aea/aii ai?no iaeaoii?io ? iaeaiioeeonoeioethth/iai ai?iiio a
e?ia? oai?eo ia ini??ac, ui i?e aiae?c? ?acii c ??aiai i?iaeoeoe?? ?ioeo
iaeai?i?aaoethth/eo ai?iii?a aeicaieeei iaa?oiooaaoe ?ieue oeeo ai?iii?a
o iaoiaaiac? ini??aco.

Aia?oa aeey e?eoaaiiy iioe?aiiai ini??aco aeei?enoaii ?ioiiiiaeoeyoi?
aetheai?i (AN ? 8278 A) ? iieacaii eiai aoaeoeai?noue: niinoa??aa?oueny
ca?eueoaiiy e?eueeino? O-noi?ani??a o ia?eaaneoey?ieo ?io?eueo?aoao
ina?aaeeo o?aaeaiiy, aeoeaaoe?y ee?oei Eaiaa?aaina a ai?aea?i?n?,
ciaioaiiy e?eueeino? eaeeioeeo?a, ui ianooue HLA-Dr aioeaai, ciaioaiiy
nooiaiy eaeeioeeoico c? ciaioaiiyi ai?noo o e?ia? O- ? A-e?ioioeeo?a,
iaeo?io?e?a, ui oaaioeeoothoue. A?io?i?/ii aeyaeaii aioeieneaeaioio ?
iaia?aiinoaa?e?coth/o ae?th aetheai?io i?e aeei?enoaii? eiai aeey
e?eoaaiiy oai?eo ia iioe?aiee ini??ac.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Aeina?ae iayaiino? iiceoeaiiai aoaeoo aeei?enoaiiy aetheai?io a
e?eoaaii? iioe?aiiai ini??aco aeicaiey? ?aeiiaiaeoaaoe eiai aeey
oe?ieiai canoinoaaiiy a aea?iaoieia??.

?acoeueoaoe aea/aiiy ai?iiiaeueieo eaiie iaoiaaiaco ini??aco ?iaeyoue
iiaeeeaei iiaeaeueoee i?aeoe/iee iiooe cania?a, ui aieeaathoue ia aeai?
eaiee iaoiaaiaco

Iniaenoee aianie aeena?oaioa.

Ianoaaeaiiy oai?eo ia ii/aoeo, a ia?aa?c? ? a e?ioe? ia??iaeo
aini?oae?caoe??; iaienaiiy iaeyaeo e?oa?aoo?e, caa?? iaoa??aeo aeey
aeine?aeaeaiiy, noaoenoe/ia ia?iaea ? aiae?c ?acoeueoao?a
aeine?aeaeaiiy, ocaaaeueiaiiy ?acoeueoao?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??.

Iaoa??aee ?iaioe aoei aeieeaaeaii ? iaaiai?aii ia eiioa?aioe?? iieiaeeo
o/aieo OAeIO o ea?oi? 1997 ?., ia can?aeaii? oiaa?enoaa
iaoieiaiaiaoii?a i. Oa?eiaa o ethoiio 1998 ?., ia i?aeiaeani?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? i?iaeaie iaoieia?? a
aeieia?/ieo oiiaao Neiaiaeaiueie” o /a?ai? 1998 ?., i. Noie.

Ioae?eaoe??.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ae?oeiaaieo ?ia?o, ?c yeeo 4
— o iaoeiaeo ? iaoeiai-i?aeoe/ieo aeo?iaeao, 1 — o iaoeiaiio
iiiioaiaoe/iiio ca??ieeo, 2 — o iaoa??aeao iaoeiaeo eiioa?aioe?e, 1 —
iaoaio ia aeiao?ae AN ? 8278 A.

No?oeoo?a oa ianya aeena?oaoe??.

?iaioa aeeeaaeaia ia 172 noi??ieao iaoeiiieniiai oaenoo. Neeaaea?oueny
?c anooio, iaeyaeo e?oa?aoo?e, /anoeie c ee?i?/iith oa?aeoa?enoeeith
oai?eo ? iienii iaoiae?a aeine?aeaeaiiy, 4-o /anoei ?c ?acoeueoaoaie
aeanieo aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a aeine?aeaeaiiy,
aeniiae?a, ia?ae?eo aeei?enoaieo aeaea?ae iaoeiai? e?oa?aoo?e, yeee
aeeth/a? 237 oe?a?inueei- ? ?in?enueeiiiaieo ? 53 ?iicaiieo aeaea?ae,
onueiai 290. ?ethno?aoeaia /anoeia i?aaenoaaeaia 21 oaaeeoeath ? 40
iaethieaie, o o./. 38 i?e?ioioia?ao?yie (ia’?iii 45 noi?.).

CI?NO ?IAIOE

Ee?i?/ia oa?aeoa?enoeea oai?eo ? iaoiaee aeine?aeaeaiiy.

I?ae niinoa?aaeaiiyi ciaoiaeeeiny 107 oai?eo ia iioe?aiee ini??ac (5-e
OAAe i. Oa?eiaa, Oa?e?anueeee iaeaniee OAAe): 49 oai?eo neeaee iniiaio
a?oio, 58 — a?oio ii??aiyiiy. Oai?? a?oie ii??aiyiiy io?eioaaee
noaiaea?oia e?eoaaiiy ini??aco, yea aeei?enoiao?oueny a aeaieo
caeeaaeao. Oea i?ioecaiaeuei?, aioea?noai?ii?, o?aiea?e?coth/? caniae,
a?oai?iioa?ai?y, i?noeaaa oa?ai?y. Oai?? iniiaii? a?oie aeiaeaoeiai aei
cae/aeii? noaie e?eoaaiiy uiaeaiii io?eioaaee aioo??oiueii’ycia?
?i’?eoe?? 20% ?ic/eio aetheai?io (eo?n 14 ?i’?eoe?e), yeee ia?
?ioiiiiaeoethth/? aeanoeaino?.

A?oie oai?eo ia ini??ac (iniiaia ? ii??aiyiiy) aiaeia?/i? ca noaooth
(aeii?iothoue /ieia?ee), a?eii (ia?aaaaeathoue a ?ioa?aae? 35-40 ?ie?a),
ee?i?/iei ae?aaiicii (iioe?aiee ini??ac), o?eaae?noth caoai?thaaiiy (a
na?aaeiueiio i?eaeecii 10 ?ie?a), ia’?eoeaiei noaoonii, ee?i?/ieie
eaai?aoi?ieie aeaieie, ui ?iaeoue i?aaii??iei aea/aiiy aoaeoeaiino?
canoinoaaiiy aetheai?io a e?eoaaii? ini??aco i?e ii??aiyii? ?acoeueoao?a
e?eoaaiiy o noi?iiaaieo a?oiao.

O oai?eo ia aeaiue aini?oae?caoe?? e ia 15-e aeaiue e?eoaaiiy i?iaiaeeee
caa?? a?iioao?a (o 19 oai?eo iniiaii? a?oie e 17 oai?eo a?oie
ii??aiyiiy) c ia?eoa??? ina?aaeeo o?aaeaiiy i?ae i?noeaaith aianoac??th
0,5% ?ic/eiii iiaiea?io. Ii?oieia?/iei eiio?ieai noaee oiaoi/ee oe??e,
aen?/ai? c iiaa?oi? ooeoaa e ?icaeiaeueieo iiaa?oiiue aa?oi?o ? ieaei?o
e?ioe?aie 10 i?aeoe/ii caei?iaeo ethaeae, ye? caaeioee a
aei?iaeiuei-o?ainii?oieo aaa??yo (i?icaeoo?a 4-? i?nueei? e?ea?i?
oaeaeei? aeiiiiiae i. Oa?eiaa). Aeei?enoiaoaaeeny oae? a?noieia?/i? oa
a?noio?i?/i? ie?ane: aaiaoienee?iii-aiceiii, i?e?iooeneiii ca Aai
A?ciiii, ia AeIE ca Oaeueaaiii-?innaiaaeii, ia ?IE ca A?aoa (c
eiio?ieai — ia?iaeith ??aiioeeaacith), ca Aaeaeaiaaeiii a iiaeeo?eaoe??
?aai, Oeoo-eiaeiith eeneioith ? ca Iaeei??.

Iioe/io u?euei?noue (Oaoey E. 1980) yaea? aacaeueiiai e oeioaaoiai oa??a
ai?aea?i?no i?e ie?anoe? ia AeIE ca Oaeueaaiii-?iinnaiaaeii aecia/aee ia
oeeoioioiiao?? c OIAE 1a (EIII). I?e aeeiiaii? aeaii? ?iaioe
cai?iiiiiaaiee ? aeei?enoaiee ii?oiiao?e/iee iieaciee “ieoiia aeiaaeeia
aacaeueii? iaia?aie ai?aea?i?no” aeey ia’?eoea?caoe?? nooiaiy
a?ia?i?ie?oa?aoe?? ai?aea?i?no. Ia oeeoieia?/iiio aiae?caoi?? “?ioaa?ae
— 2IO” (Ee?a) aei??thaaeany aeiaaeeia c??co a?iioaoo oe??e ia ??ai?
aacaeueii? iaia?aie e aeiaaeeia aacaeueii? iaia?aie ai?aea?i?no ia
aeaiiio c??c?. Ia?a?ic?aooiie aeiaaeeie aacaeueii? iaia?aie ai?aea?i?no
aeaiiai c?acea oe??e a?aeiinii 1ni eiai aeiaaeeie e aea? cia/aiiy
iieacieea “ieoiia aeiaaeeia aacaeueii? iaia?aie ai?aea?i?no”.

?ioiiii?oieia?/i? aeine?aeaeaiiy i?iaiaeeee ia ia?ao?iiaeo c??cao
oiaueiith 5-6iei iai?yiei iaoiaeii Eoina ca iaoiaeeeith Brosman. ?ioii?
ee?oeie aeeoa?aioe?thaaee ca aeiiiiiaith ieoa/eo iiiieeiiaeueieo aioeo?e
(IEA) aei ??cieo oei?a ee?oei na??? ?EI-III “Iaaea?iniaeo?”.
Aeei?enoiaoaaee ?EI-31 (CD8), -86 (CD4), -90 (CD3), -12 (CD22), -?
(HLA-Dr), -20 (CD38), -AI? (CD11b), -56 (CD45), -60 (CD18). Eieaaaie
oeioaaee IEA aei eieaaai?a I, III, IV, V oei?a. O yeino?
ethi?ianoeaioii? iicia/ee aeei?enoiaoaaee F (ab)-2 — o?aaiaioe iii?/aieo
O?OOe e?iey/eo aioeo?e i?ioe ?ioiiaeiaoe?i?a ieo?. I?aia?aoe aea/aee a
ethi?ianoeaioiiio i?e?ineii? ETHIAI E2 c aeei?enoaiiyi na?oeio?eueo??a:
ON-1-2, NCN-24, AN-8-2, OON-6-3.

Caa?? e?ia? ia ?ioiieia?/ia aeine?aeaeaiiy i?iaiaeeee a ?aieia? aiaeeie
iaouana?oea c e?eoueiai? aaie. Aea/aee ?yae ia?aiao??a, ye?
oa?aeoa?ecothoue ianiaoeeo?/io ?acenoaioi?noue (oaaioeeoa?ia aeoeai?noue
iaeo?io?e?a ia?eoa?e/ii? e?ia?) ? noai ee?oeiii? oa aoii?aeueii? eaiie
?ioi?oaoo. Eaeeioeeoa?io oi?ioeo ioe?ithaaee caaaeueiii?eeiyoeie
eaai?aoi?ieie iaoiaeaie.

E?euee?noue O-caaaeueieo e?ioioeeo?a aecia/aee a ?aaeoe?? niiioaiiiai
?icaoeiooai?aiiy (A-?IE) c a?eo?ioeeoaie aa?aia, e?euee?noue
A-e?ioioeeo?a o o?e aea ?aaeoe?? c a?eo?ioeeoaie ieo? (*a?aaeaaa A.I.,
1976). Ia/eneaiiy e?eueeino? O-noi?ani??a i?iaiaeeee iaoiaeii
oa?iinoaa?eueieo ?icaoie c a?eo?ioeeoaie aa?aia (Olinesku A., Hristescu
S., Roman S., 1987).

??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) aecia/aee
niaeo?ioioiiao?e/iei iaoiaeii oeyoii i?aoeei?oaoe?? a 3,5% ?ic/ei?
iie?ao?eaiae?eiey (A?eiaae/ TH.A., Aeoa?ia A..E., 1981). Ai?no
?ioiiaeiaoe?i?a iniiaieo eean?a (IgM, A, G) a ne?iaaooe? e?ia? aecia/aee
iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca Iai/ei? c aeei?enoaiiyi
eiia?oe?eieo iiiiniaoeeo?/ieo ne?iaaoie i?ioe ?ioiiaeiaoe?i?a ethaeeie
ae?iaieoeoaa Ieaeiueiai?iaenueeiai IAe? ai?aeai?ieia?? oa i?e?ia?ieia??.
Oaaioeeoa?io aeoeai?noue iaeo?io?e?a ia?eoa?e/ii? e?ia? ioe?ithaaee
iaoiaeii caaa?oaiiai oaaioeeoico a i?yiiio a?coaeueiiio oano?
(Eoae?yaeoeeee A.E., 1985).

Aeey aeyaeaiiy a?io?i?/ieo iniaeeainoae i?e ini??ac? i?iaiaeeee ianooii?
aeine?aeaeaiiy: aecia/aiiy a ne?iaaooe? e?ia? aeoeaiino? oea?oeiieaci?io
(Aaaaiei A.I., 1968), eaeoaoaeaa?ae?iaaiace (I?ioi?iaa I.E., 1982),
iaeaoaeaa?ae?iaaiace (Iiaeeeue/ae I.O., 1964), eaoaeace (Ia?eoaon ?.,
Niai Aeae., Eeiaeo O. n niaao., 1983), ia?ieneaeace (Anaoeaie A.N.,
1969). E??i oiai, i?iaiaeeeinue aecia/aiiy SH-a?oi e?ia? (Naaa?ei N.A.,
Nieiaueaaa A.A., 1989), aeooao?iio (I?ioi?iaa I.E., 1982). Noai
a?eueii?aaeeeaeueiiai ieeneaiiy e?i?ae?a aea/aany ca aeiiiiiaith iaoiaeo
iaaeneaaeiai na?o?iiy (AEo?aaeaa A.E., AEo?aaeaaa A.E., 1975) ia
oai?ethi?iiiao?? iaaee/iiio OEIO 1-01.

Aoiiii-aani?aoe?eiei iaoiaeii (A?eoeea I.A., 1982) aeine?aeaeoaaany
ai?no o ne?iaaooe? e?ia? i?ae?, oeeieo, cae?ca, iaai?th, eae?th,
iao??th, eaeueoe?th ia aoiiii-aani?aoe?eiiio niaeo?ioioiiao?? “Naoo?i”.
Noai iaia?ai ee?oeie aea/aany oeyoii aecia/aiiy oaeaeeino? aeoiaeo
eae?th c a?eo?ioeeo?a (Aoaneee A.E., I?ioeaiei A.I., 1970) ? aecia/aiiy
oinoie?i?ae?a (Ee?oia? TH., 1981). Aiae?coaaee ai?no o ne?iaaooe? e?ia?
aaioiaeia?io — aioeieneaeaioo e eiiieaeniooai?thaa/a (A?oeiiaa I.A.,
Oeoeeay I.I., Naiaiiaa E.N., 1988).

Aecia/aee aeoeai?noue oie?ianoa?ace e?ia? (Anaoeaie A.N., 1969),
aeai?iiai? ? ania?aa?iiai? ai?iio?ainoa?ac (?aoiaoia A.A., Aiaoe O.E.,
1991), eoaeii? oinoaoace e e?aaoeioinoie?iace (Iiae?eue/ae I.O., 1964).
Aeoeai?noue oa?iaio?a aeooao?iiia?ieneaeace, aaia-aeooai?eo?ainoa?ace,
aeueoa-a?ae?ieneaooe?aoaeaa?ae?iaaiace aeine?aeaeoaaee ca aeiiiiiaith
iaai??a ?aaeoea?a o??ie Labsystems (O?ieyiae?y) ca ?ino?oeoe?yie, ui
aeiaeathoueny, niaeo?ioioiiao?e/ii (NO-46).

Ai?no ai?iieeneio o ne?iaaooe? e?ia? aea/aee iaoiaeii ?iiiiai?iii?
o?iiaoia?ao?? ia aaoiiaoe/iiio aiae?caoi?? ai?iieeneio AAA-339 (Ci?ueeei
A.A., Eo?oea? A.I., Aeiaaaineee A.I., 1985).

Ai?iiiaeuei? aeine?aeaeaiiy e?ia? oai?eo o aeai?e ?iaio? cae?eniaii
aeaiia niiniaaie: ?aae?i?ioiieia?/iei ia RIA-iaai?ao (iaeaoii?i- ?-125,
INA — ?-125, AEOA — ?-125, ei?oecie — ?-125) — aiae?c ia onoaiiaoe? aeey
?aae?i?ioiio?i?/ieo aeine?aeaeaiue “Aaiia-800” e aae?aiae?i,
ii?aae?aiae?i ? na?ioii?i iaoiaeii eieiieiai? o?iiaoia?ao?? (Colin,
1978) c ianooiiei oethi?eiao?e/iei aiae?cii (Hithachi).

Noaoenoe/ia ia?iaea oeeo?iaeo ?acoeueoao?a i?iaiaeeeany iaoiaeaie
aa??aoe?eiiai ? ei?aeyoe?eiiai aiae?c?a c aeei?enoaiiyi AII “Pentium”.

?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe, ?O AIAE?C E IAAIAI?AIIss.

Caa?? a?iin?eiiai iaoa??aeo c ia?eoa??? ina?aaeeo o?aaeaiiy oe??e a 1-e
aeaiue aini?oae?caoe?? e ii??aiyeueia c iao?aaeaiith oe??ith aea/aiiy
i?e?ineii?/ieo i?aia?ao?a aeicaiey? aeyaeoe o oai?eo on? aaaaoi?aciai
iienai? a iaoeia?e e?oa?aoo?? (Oeaaoeiaa A.I., 1981, Eiiueaaa O.I.,
Aeaaeeie?ia A.A., 1983; Ii?aeiaoeaa A.I., 1986; Oeiiia A.A., Oaa/aiei
O.E., 1987; Aeauoe A.I., 1992) iaoiaiiiii?/i? iciaee ini??aco:
a?ia?i?ie?oa?aoe?th e iaaeinoaoi? aeeoa?aioe?thaaiiy ai?aea?iioeeo?a,
aeaioic, iineeaio i?a?aoe?th iie?ii?oiiyaea?ieo eaeeioeeo?a oa
iae?ioaa?a (ee?oei Eaiaa?aaina) a eieone ia?aea?aoico c ooai?aiiyi
aanoean?a Ioi?i, oi?ioaaiiy eaioethaa aooi?ioiieo ?aaeoe?e ia
ai?aea?iaeuei? a?eee c i?a?aoe??th O- ? A-e?ioioeeo?a o ia?eeai?ey?i?
i?inoi?e aea?ie ? c a?ia?i?iaeoeoe??th ?ioiiaeiaoe?i?a, a iio?i ? Oe?E,
ye? a?aeeeaaeathoueny ia aacaeueieo iaia?aiao noaeei
i?e?ioee?eoeyoi?iiai ?onea aea?ie. Iaa?ye ? a?iioiene/iee noai
ciai?oiueiai oa?o aea?ie iaoiiaeththoue i?ioeane iae?ia?ico iniiaii?
?a/iaeie e aieieii aea?ie, ui noa? ii/aoeii iiaiai eaioethaa aooi?ioiii?
?aaeoe?? ia a?eee aea?ie.

?ioiiii?oieia?/ia aeine?aeaeaiiy oe??e e ?ioiieia?/ia aeine?aeaeaiiy
e?ia? i?aeoaa?aeaeothoue i?aaenoaaeaiee ii?yaeie ?icai?oaiiy iiae?e.
Niinoa??aaee ciaioaiiy e?eueeino? O-noi?ani??a o ia?eaaneoey?ieo
?io?eueo?aoao aea?ie, e?cen ? iaineioac eieaaai?a o aacaeueieo iaia?aiao
? niieo/i?e oeaiei?, ae?aaeaiee eaeeioeeoic ? ca?eueoaiiy e?eueeino?
oaaioeeooth/eo iaeo?io?e?a e aaeoa?eoeeaeii? ?ieino? e?ia?,
a?ia?aeiaoe?iai?th. A?aecia/aia o oai?eo ia ini??ac aeoeaoaaiiy IIE
i?ecaiaeeoue aei aeniaaeaiiy aioeieneaeaioii? nenoaie, ii?ooaiiy
no?oeoo?e e i?iieeeeaino? iaia?ai, ci?ie aeoeaiino? aaaaoueio oa?iaio?a,
ia?a?icae?eo i?e?iaeaiaio?a; noeoii?noue oeeo i?ioean?a i?ecaiaeeoue aei
aeeaieiai ii?ooaiiy a?eeiaiai, aoaeaaiaeiiai e aee?iaiai iai?i?a.

Ieoaiiy i?i ?i?oe?thth/ee i?ie?oa?aoe?th ai?aea?i?na iiiaio ia aeaiee
/an ia ae??oaii. O iaoiio ?icii?yaeaeaii? ? aeayea e?euee?noue
e?oa?aoo?ieo ? aeanieo oaeo?a, ye? na?ae/aoue i?i aacoiiaio i?e/aoi?noue
iaeai?io aei iaoai?cio ini??aoe/iiai i?ioeano.

Aiae?c ?acoeueoao?a aecia/aiiy ai?noo a e?ia? oeacaieo aeua ai?iii?a
iieacaa, ui o an?o oai?eo ia iioe?aiee ini??ac a noaae?? i?ia?an?? ia?
i?noea ?noioia a?ia?aae?aiae?iai?y oa a?iiii?aae?aiae?iai?y,
a?ia?na?ioii?iai?y oa a?iiiaeaoii?iai?y, ye i?aeaeuaiiy, oae ? cieaeaiiy
ai?noo a e?ia? INA, iayai?noue AEOA ? ei?oecieo ia ieaeiueiio ??ai?
ii?ie aai ieae/a eiai. Aecia/aiiy ni?aa?aeiioaiiy ai?iii?a o ia?ao
aae?aiae?i-ii?aae?aiae?i, na?ioii?i-iaeaoii?i, iaeaoii?i-INA
i?aeoaa?aeaeo? ?o aca?iica’ycie e ?noioio ?ieue ?o ii?ooaiiy a
iaoiaaiac? ini??aco. Iiooe iiaeeeaiai ii/aoeo eaioethaa ai?iiiaeueieo
ci?i coieiea iaoo oaaao ia aae?aiae?i?, ai?iii?, yeee aeoeaii
aeae?ey?oueny iiceiaith ?a/iaeiith iaaeie?iee?a a oiiaao no?ano. O?eaaea
a?ia?aae?aiae?iai?y iiaea iioyaoe ca niaith a?iiii?aae?aiae?iai?th,
ine?eueee ii?aae?aiae?i ooai?th?oueny c aae?aiae?io. Ii?aae?aiae?i, ye
a?aeiii (Neaiooeei A.Ae., Iaoeineee A.A., 1982), caaacia/o? o?ainii?o
o?eioioaio a ai?iiiaeueii aeoeaio ee?oeio ai?o?co iiceo e ca?eueoaiiy
ooai?aiiy oeeee?/iiai aaeaiiceiiiiioinoaoo, yeee ae?? ia aoeaoeethaaiiy
na?ioii?io e ia?aoai?aiiy eiai a N-aoeaoeena?ioii?i ? aeae? o iaeaoii?i.
Oiaoi a neooaoe??, yea aiae?co?oueny, aeao?oeeo ii?aae?aiae?io cao?eio?
ooai?aiiy iaeaoii?io ?c na?ioii?io, ? niinoa??aa?oueny ia?aeaeueii
a?ia?na?ioii?iai?y e a?ia?iaeaoii?iai?y. Na?ioii?i noeioeth?
i?iaeoeoe?th AEOA, yea a oiiaao no?ano e oae aoea aaea a noai?
noeioethaaiiy. Oiio, i/aaeaeii, ianoa? oaeaeea ae/a?ii?noue
AEOA-i?iaeoeooth/eo ee?oei aaeaiia?iio?co ? i?ney oeueiai — iecueea aai
ia iecuee?e iaae? ii?ie i?iaeoeoe?y ei?oecieo. I?e ae/a?iiino? ooieoe??
AEOA — i?iaeoeooth/eo ee?oei eiiiainaoi?ii ianoa? a?ia?i?iaeoeoe?y INA,
ine?eueee iaeaeaa oe? ai?iiie neioacothoueny ?c caaaeueiiai aeaea?aea e
ooieoe?? /anoeiai ia?ao?auothoueny, cie?aia, AEOA caeaoiee iineeeoe
neioac iaeai?io a iaeaiioeeoao (Hunt G., Togg C., Kyne S., at all.,
1994). Oaeiae oe?iei a?aeiiee oaeo iinea?iiy i?ney neeueieo no?an?a,
oiaoi no?an i?ecaiaeeoue aei ae/a?iiino? noanoaioe?e, noeioethth/eo
ooai?aiiy iaeai?io o aieinyieo oeeaoeeiao.

Ca?aeii c iaea?aeaieie o aeaiiio aeine?aeaeaii? oeeo?aie, i?iaeoeoe?y
AEOA o noai? aeniaaeaiiy, a INA — o a?eueoino? aeiaaee?a o noai? aeniei?
eiiiainaoi?ii? iai?oae, ??aeoa — aeniaaeaiiy. Oiio iiaeia ia?aaeaa/eoe
cieaeaiiy neioaco iaeai?io a iaeaiioeeoao oe??e. A iecueeee ??aaiue
i?iaeoeoe?? iaeaoii?io a ai?o?c? iiceo iaoiiaeth? i?a?aoe?th ooai?aieo a
iaeaiioeeoao o ciaioai?e e?eueeino? iaeaiinii o i?aeee?oeiiiio i?inoi??,
aea aiie caoiieththoueny o ia?oo /a?ao ee?oeiaie Eaiaa?aaina. A?aeiii,
ui iayai?noue iaei? e?eueeino? iaeaiinii o ee?oei? Eaiaa?aaina
ii?aeio?oueny c? cieaeaiiyi i?iaeoeoe?? ieie eaeeii?a (O?ieia A.I.,
1982), a aiie i?yii aaeueiothoue i?ie?oa?aoe?th aacaeueieo
ai?aea?iioeeo?a, oiaoi oaeei /eiii iiaea aeieeiooe a?ia?i?ie?oa?aoe?y
ai?aea?iioeeo?a c on?ia ianooiieie i?ioeanaie.

Ia noai? i?aaenoaaeaia aaeocea ai?iiiaeueii-oe??ieo ca’yce?a,
aeeeaaeaieo a aeai?e a?iioac?.

Aeaa oeaei? e?eoaaiiy oai?eo ia iioe?aiee ini??ac ?c a?oie ii??aiyiiy,
oiaoi ?c canoinoaaiiyi i?ioecaiaeueieo, aeanainea?e?coth/eo,
o?aiea?e?coth/eo i?aia?ao?a, a?oai?iioa?ai??, ciai?oiuei?, a o./.
i?noeaai?, oa?ai??, ? c iniiaii? a?oie, oiaoi c aeiaeaoeiaei
aeei?enoaiiyi aetheai?io, iaoiiaeee oae? ?acoeueoaoe.

Ciaeaeaii, ui i?eaeecii o iaeiaeiai? /anoeie oai?eo iaio a?oi ia? i?noea
ae?acia ?aa?an?y iaoiii?oieia?/ieo iciae, o /anoeie – niinoa??aa?oue-ny
noaa?e?caoe?y, o /anoeie eaea iiaeaeueoa i?ia?anoaaiiy iaoieia?/iiai
i?ioea-no. Iaeiae canoinoaaiiy ii?oiiao?e/iiai iieacieea “e?euee?noue
ee?oei Eai-aa?aaina ia 10 ee?oei aacaeueiiai oa oeioaaoiai oa??a
ai?aea?i?no” (ca?eue-oaiiy cia/aiiy), ?ioiiii?oieia?/ieo iieaciee?a
(i?aeaeuaiiy CD8-noi?a-ni?ii? aeoeaiino? a ia?eaaneoey?ieo ?io?eueo?aoao
aea?ie, a?eueo iii?oia ciaioaiiy e?eueeino? eaeeioeeo?a c HLA-Dr
aioeaaiii), aiae?c ee?i?/ieo ?ioiieia?/ieo iieaciee?a (a?eueo ae?acia
ciaioaiiy ai?noo ??cieo aeae?a eaeeioeeo?a a iaeeieoe? ia’?io e?ia?, o
o./. O- ? A-e?ioioeeo?a, oaaioeeooth/eo iaeo?io?e?a) ia’?eoeaii
i?aeoaa?aeeee a?eueoo oni?oi?noue aeai-oeaeiaaiai e?eoaaiiy oai?eo ia
iioe?aiee ini??ac c iniiaii? a?oie.

I?iaaaeaia aeai-oeaeiaaa e?eoaaiiy i?ecaaei aei nooo?aiai cieaeaiiy
?ioaineaiino? IIE ye a iniiai?e a?oi?, oae ? a a?oi? ii??aiyiiy. Iaeiae
a iniiai?e a?oi? ci?ie a?eueo ae?aaeai?. O oai?eo iniiaii? a?oie
aeinoia??ii cieaeo?oueny ai?no SH-a?oi, o oie /an, ye o oai?eo a?oie
ii??aiyiiy oeae iieaciee i?aeoe/ii ia ci?ith?oueny (oaae. 1, 2).

Oaaeeoey 1

Noai a?eueii-?aaeeeaeueiiai ieeneaiiy e?i?ae?a o oai?eo ia ini??ac
ii??aiyii c aeiii?aie

A?oie

Niinoa?aaeai. Iieacieee (M+m)

IAeA (ieI/e) Ae??iia? eii’thaaoe (ieI/e) ?ioaineai?noue AOE (1/nae)

Aeiii?e

N=105 8.11+0.29 59.97+2.72 650+25

A?oia ii??aiyiiy aei e?eoaaiiy n=45 22.1+2.0 p<0.01 73.52+3.8 p<0.01 980+44 A?oia ii??aiyiiy i?ney e?eoaaiiy n=34 22.62+2.03 p<0.01 p2>0.1
60.27+3.08 p>0.1 p2<0.05 820+27 Iniiaia a?oia aei e?eoaaiiy n=33 29.27+1.6 p<0.001 78.27+1.8 p<0.01 1050+36 Iniiaia a?oia i?ney e?eoaaiiy n=25 15.17+1.38 p<0.01 p2<0.01 65.66+2.3 p<0.05 p2<0.05 720+28 p<0.05 p2<0.001 Oaaeeoey 2. Noai aioeieneaeaioii? nenoaie ca aeayeeie iieacieeaie o oai?eo ia ini??ac A?oie Niinoa?aaeai. Iieacieee (M+m) SH-a?oie (iI/e) A?aeiiaeaiee aeooao?ii (iI/e) Aaioiaeia?i (a/e) Aeiii?e n=26 11.12+0.7 1.15+0.05 2.2+0.9 A?oia ii??aiyiiy aei e?eoaaiiy n=45 28.53+1.32 p<0.001 0.72+0.05 p<0.001 1.3+0.08 p<0.05 A?oia ii??aiyiiy i?ney e?eoaaiiy n=34 26.15+1.86 p<0.001 p2>0.1
0.73+0.05 p<0.001 p2<0.1 1.45+0.07 p<0.05 p2<0.05 Iniiaia a?oia aei e?eoaaiiy n=33 18.76+1.1 p<0.001 1.07+0.1 p<0.1 1.25+0.05 p<0.01 Iniiaia a?oia i?ney e?eoaaiiy n=25 14.34+1.38 p<0.05 p2<0.05 1.24+0.094 p>0.1 p2>0.1 1.64+0.1 p<0.05 p2<0.05 O ?acoeueoao? cieaeaiiy ?ioaineaiino? a?ioai?ethi?ianoeaioe??, ui a?aeia?aaea? ci?io nooiaiy ?ioieneeaoe?? i?aai?cio, ? a?eueo ae?aaeaiei a iniiai?e a?oi?. A?aoiaoth/e, ui nooi?iue ci?ie ai?noo ?ioeo eiiiiiaio?a aioeieneaeaioii? nenoaie (a?aeiiaeaiee aeooao?ii, aaioiaeia?i) iaeiaeia? a iaio aeine?aeaeoaaieo a?oiao oai?eo, iiaeia i?eionoeoe, ui aetheai?i ia? ae?aaeaiee aioeieneaeaioiee aoaeo (oaae.2). Cieaeaiiy ??aiy IIE oa ai?noo a?ae?iia?aeen?a, ui a?aei?/a?oueny, a?aeia?aaea?oueny ia e?i?aeiiio niaeo?? iaia?ai. I?iaaaeai? iaie aeine?aeaeaiiy iieacaee, ui oinoie?i?aeiee neeaae iaia?ai a?eo?ioeeo?a o oai?eo iniiaii? a?oie a?aeiiaeth?oueny i?ney e?eoaaiiy. O oie aea /an o a?oi? ii??aiyiiy ai?no e?cioinoie?i?ae?a caeeoa?oueny aeineoue aenieei. Io?eiai? ?acoeueoaoe aeicaieythoue c?iaeoe aeniiaie i?i iaia?aiinoaa?e?coth/? aeanoeaino? aetheai?io. Iiaeeeai, oe? aeanoeaino? iia’ycai? c oei, ui aetheai?i ? iio?aeiei o?oeio ?aeiiiae?aieo, ca nopoeoo?ith aeecueeee aei oinoie?i?ae?a ? oiio iiaea aeeth/aoenue aei neeaaeo oinoie?i?ae?a, aeiiiaithth/e aeao?oeeoi? eiiiiiaioe. Eiia??ii, aeinyaiooee iaia?aiinoaa?e?coth/ee aoaeo ? iniiaith aeey a?aeiiaeaiiy ?iiiiai o?ainii?oo oa aeoeaiino? iaia?aiiniieo/aieo oa?iaio?a. Oae, ci?ie aeoeaiino? aaia-aethoai?eo?ainoa?ace, ui a?aei?/ai? iaie, eiia??ii, ca’ycai? ?c noaa?e?caoe??th e?i?aeiiai a?ioa?o. O naith /a?ao, a?aeiiaeaiiy ai?noo aaia-aethoai?eo?ainoa?ace o iaia?aiao i?ecaiaeeoue aei ii?iae?caoe?? o?ainii?oo ai?iieeneio ?, ye iane?aeie, aei ?ioaineo?eaoe?? neioaco a?ee?a. Ii?iae?caoe?y o?ainii?oo ?ii?a /a?ac oeeoiieaciaoe/io iaia?aio iieacaia iaie ia i?eeeaae? o?ainii?oo ?ii?a eae?th aei a?eo?ioeeo?a. I?aeaiaey/e i?aenoiie aeine?aeaeaiiy c aea/aiiyi aoaeoeaiino? canoinoaaiiy aetheai?io a e?eoaaii? iioe?aiiai ini??aco, a?aei?/a?ii, ui a iniiai?e a?oi? oai?eo aeinoia??ii ?ai?oa i?ae o a?oi? ii??aiyiiy ianoaea noaa?e?caoe?y (11,7+0,9 aeia. ? 15,3+0,7 aeia.) ? ?aa?an?y (15,3+0,7 aeia. ? 17,4+1,2 aeia.) ini??aoe/iiai i?ioeano; aeinoia??ii iaioa o?eaae?noue aini?oae?caoe?? (26,5+1,3 aeia. ? 28,9+1,1 aeia.). Oaeei /eiii, ia?ae?e ai?iaiaaieo ia aeaiee iiiaio aeey e?eoaaiiy ini??aco ?ioiiiiaeoeyoi??a (oeeeeinii??i (Stuttgen G., Brinkmann-Raestrupp I., Haller L., at all. 1979; Mcfadden J.P., 1990); aioenoao?eieieiaa ieacia (Oaeueea? A.ss., 1987); aeeo?ii (A?eoei O.I., Iaceia I.I., Ii?aeiaoeaa A.I., 1992); oeiae?i ? AOeN Aiaiiieueoey (Aeauoe A.I., 1992), aeiiiaiaiee aetheai?iii. AENIIAEE O noaae?? i?ia?an?? iioe?aiiai ini??aco a?aei?/a?oueny aeoaea ae?aaeaia aeoeaaoe?y i?e?ioaaioeeoa?iiai eaioethaa ?ioi?oaoo, O- ? A-nenoai, ?ioii-aeiaoe?iii?iaeoeoe??; ?ioiiii?oieia?/ii aeyaeaii aeii?ioaaiiy O-oaeia??a iaae O-noi?ani?aie a ia?eaaneoey?ieo ?io?eueo?aoao, iciaee ?iciaaeo oa neioaco eieaaai?a aea?ie ? aacaeueii? iaia?aie ai?aea?i?no; i?e aeine?aeaeaii? a?noieia?/ieo i?aia?ao?a oe??e aeyaeaia aeoeaaoe?y e iciaee aeniaaeaiiy ee?oei Eaiaa?aaina a ai?aea?i?n?. A?io?i?/ii anoaiiaeaii i?aeaeuaiiy ai?noo a e?ia? o oai?eo ia ini??ac ia?aeen?a, a?ae?iia?aeen?a, a?eueieo ?aaeeeae?a, ae??iiaeo eii’thaao?a, iaeiiiaiai ae?aeueaeaa?aeo, c iaeiiai aieo, ? cieaeaiiy ai?noo a e?ia? SH-a?oi, aeooao?iio, aaioiaeia?io, eaoaeace, ia?ieneaeace, aeooao?iiia?ieneaeace, c ?ioiai aieo, ui na?ae/eoue i?i ii?ooaiiy noaoe?iia?ii? ??aiiaaae i?iieneaeaioii? ? aioeieneaeaioii? nenoai a a?e i?aeaeuaiiy ieenethaaeueieo i?ioean?a. Aeoeaaoe?y a?eueii-?aaeeeaeueiiai ieeneaiiy e?i?ae?a o oai?eo ia ini??ac i?ecaaea aei aeniaaeaiiy aioeieneaeaioii? nenoaie, iiieaeaiiy aioeieenethaaeueii? caeaoiino? oeaiei i?aai?cio, oea aea? i?aenoaao aaaaeaoe, ui a iaoai?ci? ?icaeoeo aeaiiai caoai?thaaiiy aaaeeeaa cia/aiiy ia? a?eueii-?aaeeeaeueia iaoieia?y. Aea/aiiy ai?noo a e?ia? oai?eo ia ini??ac aae?aiae?io, ii?aae?aiae?io, ei?oecieo aeyaey? ??ceo aeoeaaoe?th aae?aiaeiaiai a?aeae?eaiiy neiiaoiaae?aiaeiai? nenoaie (ni?aa?aeiioaiiy ii?aae?aiae?i/aae?aiae?i noa? a 4 ?ace ieae/a i?ae o caei?iaeo ethaeae), ui iiaeia o?aeooaaoe ye i?e/eio aaeueioaaiiy neioaco iaeaoii?io a ai?o?c? iiceo. Aeyaeaia i?aeaeuaiiy ai?noo na?ioii?io e ??cea cieaeaiiy ai?noo iaeaoii?io a e?ia? oai?eo ia ini??ac na?ae/eoue i?i ii?ooaiiy ooieoe?iiaeueiiai noaio ai?o?co iiceo, ui, eiia??ii, eaaeeoue a iniia? naciiii-caeaaeieo caaino?aiue ini??aco. Onoaiiaeaiiy oaeoo ae/a?iiino? nae?aoe?? AEOA ? INA o oai?eo ia ini??ac ia oii? iecueei? i?iaeoeoe?? iaeaoii?io ai?o?cii iiceo aeicaiey? ia?aaeaa/eoe iiaeeea?noue ?icaeoeo i?e oeueiio ini??aoe/ii? i?ie?oa?aoe?? ai?aea?i?no ca aeiiiiiaith aieeao oeeo ai?iii?a ia iaeai?iiooai?aiiy a iaeaiioeeoao ai?aea?i?no e i?a?aoe?th iaeaiinii o ee?oeie Eaiaa?aaina. Aeiaeaoeiaa canoinoaaiiy aetheai?io i?e e?eoaaii? oai?eo ia iioe?aiee ini??ac i?ecaiaeeoue aei aeinoia??iiai i?enei?aiiy noaa?e?caoe?? ini??aoe/iiai i?ioeano, ii/aoeo ?aa?ano oa aei nei?i/aiiy o?eaaeino? aini?oae?caoe??. Aeine?aeaeaiiy a?iin?eiiai iaoa??aeo aeyaeei, ui i?ney aeaioeaeiaaiai e?eoaaiiy oai?eo ia iioe?aiee ini??ac ?c canoinoaaiiyi aetheai?io, oae ye ? a a?oi? ii??aiyiiy, iiaea niinoa??aaoeny noaa?e?caoe?y, i?ia?anoaaiiy oa ?aa?an iaoieia?/iiai i?ioeano a aiaeia?/ieo ni?aa?aeiioaiiyo. A?aei?oiei aeey iniiaii? a?oie oai?eo ? oa, ui aieea aeei?enoaiiy aetheai?io iicia/eany ia aeoeaaoe?? ee?oei Eaiaa?aaina o an?o ianoaaeaieo oai?eo. O an?o oai?eo iniiaii? a?oie ?ioiiii?oieia?/ii a?aecia/a?oueny ciaioaiiy e?eueeino? ee?oei c HLA-Dr aioeaaiii o neeaae? ?io?eueo?ao?a ? iineeaiiy CD8-noi?ani?ii? aeoeaiino?. I?e ?ioiieia?/iiio aeine?aeaeaii? e?ia? o a?eueoino? oai?eo iniiaii? a?oie a i?ioean? e?eoaaiiy aeyaeaii ae?acia ciaioaiiy e?eueeino? eaeeioeeo?a a iaeeieoe? ianyao e?ia?, a o./. O- ? A-e?ioioeeo?a, oaaioeeooth/eo iaeo?io?e?a, oiae? ye o a?oi? ii??aiyiiy - o iaioino? oai?eo. A?io?i?/ii aeyaeaii aioeieneaeaioio ? iaia?aiinoaa?e?coth/o ae?th aetheai?io, ui ?aaoeth? ia?aa?a aaaaoueio i?ioean?a a i?aai?ci? oa ni?ey? ii?iae?caoe?? aiiainoaco. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey e?eoaaiiy iioe?aiiai ini??aco ?aeiiaiaeo?oueny aeei?enoiaoaaoe eo?n uiaeaiieo ?i’?eoe?e aetheai?io i?ioyaii aeaio oeaei?a c iaoith noeioeyoe?? oa ?ia?a??oaaiiy ie?aieo eaiie ?ioiii? a?aeiia?ae? i?aai?cio. 2. I?iiiio?oueny aeei?enoiaoaaoe ii?oiiao?e/iee e?eoa??e “ieoiia aeiaaeeia aacaeueii? iaia?aie ai?aea?i?no” ? a?io?i?/iee iieaciee “aeoeai?noue aaia-aeooai?eo?ainoa?ace” aeey eiio?ieth ca ye?noth e?eoaaiiy oai?eo ia ini??ac. 3. Aecia/aiiy o oai?eo ia ini??ac ai?noo a e?ia? aae?aiae?io, ii?aae?aiae?io ? na?ioii?io iaoiaeii o?iiaoia?ao?? aeicaieeoue cae?enithaaoe eiio?ieueiaaia aioeno?aniaa e?eoaaiiy. NIENIE Ae?OEIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. A?ioa A.A. Niaea?aeaiea aeieiae/aneeo aieiia a e?iae aieueiuo ini?eacii // Aea?iaoieiaey e aaia?ieiaey.- 1998.- ? 2 (6).- N. 38-40. 2. A?ioa A.A. Aeiioacu yoeiiaoiaaiaca ini?eaca // Aea?iaoieiaey e aaia?ieiaey.- 1998.- ? 2 (6).- N. 63-65. 3. A?ioa I.A. Ei?oecie oa AEOA o ne?iaaooe? e?ia? oai?eo ia ini??ac aei e?eoaaiiy oa a i?ioean? eiai e?eoaaiiy // Oe?a?inueeee ?aae?ieia?/iee aeo?iae.- 1998.- O. 6.- Aei. 2.- N. 157-158. 4. A?ioa A.A. Iaeioi?ua iniaaiiinoe iaoaaieecia o aieueiuo ini?eacii // A?a/aaiay i?aeoeea.- 1998.- ? 2.- N. 69-70. 5. Iao. ? 8278 A, Oe?a?ia, ia aeiao?ae: Niin?a e?eoaaiiy ini??aco / A?ioa I.A., Aeauoe A.I. / Iioae. 29 aa?aciy 1996 ?. 6. A?ioa A.A. Aenoieiae/aneea e aenoioeie/aneea iieacaoaee niaaeeieoaeueiie oeaie aea?iu o aieueiuo ini?eacii // Iaoa?eaeu iao/ii-i?aeoe/aneie eiioa?aioeee “Aeooaeueiua aii?inu i?ioeeaeoe/aneie iaaeeoeeiu”.- Oa?ueeia.- 1996.- N. 163-166. 7. A?ioa A.A. Ii?oieiae/aneay ioeaiea eioaineaiinoe aeia?i?ieeoa?aoeaiiai i?ioeanna a yieaea?iena eiaee i?e ini?eaca // Oac. aeiee. ?anioaeeeaineie iao/ii-i?aeoe/aneie eiioa?aioeee iieiaeuo o/aiuo e niaoeeaeenoia “Nia?aiaiiua ooiaeaiaioaeueiua e i?eeeaaeiua i?iaeaiu eeeieee aioo?aiieo aieaciae”.- Oa?ueeia.- 1997. - N.19. 8. A?ioa A.A. Ii?oieiae/aneea ia?aeeaee i?e ini?eaca // Iaaeeoeeia naaiaeiy e caao?a. Na. ?aaio iieiaeuo o/aiuo e niaoeeaeenoia.- Oa?ueeia. - 1997. - Aui. 2. - N. 31-32. A?ioa I.A. Aetheai?i o eiiieaeni?e oa?ai?? oai?eo ia ini??ac. ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.20 – aea?iaoieia?y, aaia?ieia?y. - Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey, Ee?a, 1998. Aeena?oaoe?y i?noeoue a?aeiiino? i?i iiceoeaiee aoaeo aeei?enoaiiy 14-oeaeaiiiai eo?no ?i’?eoe?e aetheai?io i?e e?eoaaii? iioe?aiiai ini??aco. Aeyaeaii i?enei?aiiy noaa?e?caoe?? oa ?aa?ano iaoieia?/iiai i?ioeano, ciaioaiiy o?eaaeino? aini?oae?caoe?? oai?eo. I?e oeueiio niinoa??aa?oueny ciaioaiiy ai?noo ??cieo aeae?a eaeeioeeo?a a iaeeieoe? ianyao e?ia?, o o./. O- ? A-e?ioioeeo?a, a oaeiae oaaioeeooth/eo iaeo?io?e?a, ca?eueoaiiy e?eueeino? ee?oei Eaiaa?aaina a ai?aea?i?n?, i?aeaeuaiiy O-noi?ani?ii? aeoeaiino? a ia?eaaneoey?ieo ?io?eueo?aoao aea?ie, a?eueo ae?aaeaia ciaioaiiy e?eueeino? eaeeioeeo?a c HLA-Dr aioeaaiii. A?io?i?/ii onoaiiaeai? aioeieneaeaioiee ? iaia?aiinoaa?e?coth/ee aoaeoe aetheai?io. Ai?iiiaeueia aeine?aeaeaiiy e?ia? oai?eo ia ini??ac aeicaieeei aeiaanoe o/anoue iaeaoii?io ? iaeaiioeeonoeioethth/iai ai?iiio a iaoiaaiac? ini??aco e cai?iiiioaaoe aeanio a?iioaco ?i?oe?ae?caoe?? a?ia?i?ie?oa?aoe?? ai?aea?iioeeo?a c aeeth/aiiyi a iaoiaaiaoe/iee eaioetha ai?iii?a, ye? aa?ooue o/anoue o no?ania?e ?aaeoe??, ? aeuaiacaaieo ai?iii?a. Eeth/ia? neiaa: ini??ac, e?eoaaiiy, ?ioiiiiaeoeyoi?, ai?iiie, a?iioaca iaoiaaiaco. A?ioa A.A. Aetheaiei a eiiieaeniie oa?aiee aieueiuo ini?ea-cii. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.20 – aea?iaoieiaey, aaia?ieiaey. – OAIO IIC Oe?aeiu, Oa?ueeia, 1998. Aeenna?oaoeey niaea?aeeo naaaeaiey i iieiaeeoaeueiii yooaeoa eniieueciaaiey 14-oeaeiaaiiai eo?na eiuaeoeee aetheaieia i?e ea/aiee aeennaieie?iaaiiiai ini?eaca. Iaia?oaeaii onei?aiea noaaeeecaoeee e ?aa?anna iaoieiae/aneiai i?ioeanna, oiaiueoaiea i?iaeieaeeoaeueiinoe ainieoaeecaoeee aieueiuo. I?e yoii iaaethaeaaony oiaiueoaiea niaea?aeaiey ?aciuo aeaeia eaeeioeeoia a aaeeieoea iauaia e?iae, a oii /enea O- e A-eeioioeeoia, a oaeaea oaaioeeoe?othueo iaeo?ioeeia, oaaee/aiea eiee/anoaa eeaoie Eaiaa?aaina a yieaea?iena, iiauoaiea O-noi?anni?iie aeoeaiinoe a ia?eaaneoey?iuo eioeeueo?aoao aea?iu, aieaa au?aaeaiiia oiaiueoaiea eiee/anoaa eaeeioeeoia n HLA-Dr aioeaaiii. Aeioeie/anee onoaiiaeaiu aioeieneaeaioiue e iaia?aiinoaaeeece?othuee yooaeou aetheaieia. Ai?iiiaeueiua enneaaeiaaiey e?iae aieueiuo ini?eacii iicaieeee aeieacaoue o/anoea iaeaoiieia e iaeaiioeeonoeioee?othuaai ai?iiia a iaoiaaiaca ini?eaca e i?aaeeiaeeoue nianoaaiioth aeiioaco eieoeeaoeee aeia?i?ieeoa?a-oeee yieaea?iioeeoia n aeeth/aieai a iaoiaaiaoe/aneoth oeaiue ai?iiiia, o/anoaothueo a no?anniaie ?aaeoeee, e auoaiacaaiiuo ai?iiiia. Eeth/aaua neiaa: ini?eac, ea/aiea, eiioiiiiaeoeyoi?, ai?iiiu, ae-iioaca iaoiaaiaca. Broshe Ye.A. Glucamin in complex therapy of patients with psoriasis.- Manuscript. Thesis for scientific degree of Candidate Medical Science in speciality No. 14.01.20 - Dermatology and Venerology. - National Medical University, Ministry of Public Health of Ukraine, Kiev, 1998. The thesis contains information about a positive effect of using 14-days' course of glucamine injections in treatment of disseminated psoriasis. Acceleration of stabilization and regression of the pathogical process, as well as reduction in the period of hospitalisation of the patients, have been revealed. Therewith, a decreased content of different kinds of leukocytes in a unit of blood volume, including T- and B-limphocytes, as well as phagocyting neutrophils, along with an increased number of Langerhans cells in the epidermis, an intensified CD8-suppressor activity in perivascular infiltrationes of the derma, a more pronounced reduction in the amount of leukocytes with HLA-Dr antigen have been observed. Biochemically, antioxidant and membrane-stabilizing effects of glucamine have been revealed. Hormonal study of patients with psoriasis has made it possible to prove participation of melatonin and the melanocyte-stimulating hormone in pathogenesis of psoriasis and to suggest the author's own hypothesis of initiation of epidermocytes hyperproliferation with inclusion of the hormones, which take part in a stress response, and the hormones as above into the pathogenetic chain. Key words: psoriasis, treatment, immunomodulator, hormones, hypothesis of pathogenesis. PAGE 14

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